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The aim of this study is to see if the study medicine is safe, how it works in participants body, and what the body does to the study medicine. |
Participants will either get NNC6022-0001 (the new study medicine) or placebo (a "dummy medicine" without the active ingredient). Which treatment participants get is decided by chance. The study medicine is a potential new medicine which cannot be prescribed by doctors. |
The study will last for about 10 months in total. conditions: Healthy Volunteers conditions: Cardiometabolic Diseases studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: Sponsor staff involved in the clinical trial ... |
<|newrecord|> nctId: NCT06335992 id: Dnr 2022-00831-01 briefTitle: Tissue Regeneration in Patients With Chronic Obstructive Pulmonary Disease After an Exercise Intervention. acronym: T-Rex overallStatus: RECRUITING date: 2022-09-01 date: 2025-02-28 date: 2025-04-30 date: 2024-03-28 date: 2024-03-28 name: Uppsala Univer... |
Objectives (i) Evaluate biomarkers for regenerative processes, matrix turnover, stem cell activity and inflammatory patterns in lung tissue biopsies, blood- and urine samples correlated to vital lung parameters and physical capacity, before and after attending an exercise-training program. |
(ii) Study the effects of exercise training on the pulmonary ventilation/perfusion ratio and quality of life. |
(iii) Evaluate the relation between pathophysiology in the lung evaluated by CT scan, and systemic response measured by muscle biopsies and biomarkers in blood/urine. |
(iv) Investigate in vitro cell behaviour and remodelling/regenerative processes altered in COPD patients upon exercise training (aim 1). conditions: Chronic Obstructive Pulmonary Disease studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 80... |
<|newrecord|> nctId: NCT06335979 id: CPIT565B12101 id: 2023-510025-14-00 type: OTHER domain: EU CT briefTitle: An Ascending Dose Study of PIT565 in Participants With Systemic Lupus Erythematosus (SLE). overallStatus: NOT_YET_RECRUITING date: 2024-12-16 date: 2028-08-23 date: 2028-08-23 date: 2024-03-28 date: 2024-04-11... |
<|newrecord|> nctId: NCT06335966 id: STUDY00025975 briefTitle: BEST-RPP Pilot: Screening for Esophageal Cancer in Rural Oregon Without an Endoscopy acronym: BEST-RPP overallStatus: RECRUITING date: 2024-01-25 date: 2025-01-30 date: 2025-01-30 date: 2024-03-28 date: 2024-03-28 name: OHSU Knight Cancer Institute class: O... |
<|newrecord|> nctId: NCT06335953 id: IRB00418404 id: U54AG063546 type: NIH link: https://reporter.nih.gov/quickSearch/U54AG063546 briefTitle: ALIGN: Aligning Medications With What Matters Most (Demonstration) overallStatus: NOT_YET_RECRUITING date: 2024-04-18 date: 2025-04 date: 2025-04 date: 2024-03-28 date: 2024-04-2... |
The intervention consists of the following strategies: 1) a de-prescribing educational brochure designed to activate the patient and care partner; 2) a single telehealth visit in which an embedded clinical pharmacist discusses the benefits and harms of the patient's medications with the patient and care partner in the ... |
The investigators will compare the intervention group with the waitlist control group to see if there is a difference in the primary outcome, the proportion of patients who deprescribe at least one medication by 3 months. conditions: Polypharmacy conditions: Alzheimer's Disease and Related Dementias conditions: Mild Co... |
<|newrecord|> nctId: NCT06335940 id: 38RC23.0376 briefTitle: Admission for Respiratory Disease And VIdeo Regulation System acronym: ARAVIS-PED overallStatus: NOT_YET_RECRUITING date: 2024-04-08 date: 2024-07-31 date: 2024-10-18 date: 2024-03-28 date: 2024-04-02 name: University Hospital, Grenoble class: OTHER briefSumm... |
Proper referral of patients calling the SAMU Centre-15 takes on its full meaning in this context, but regulating paediatric calls is more difficult. Indeed, the regulating doctor is most often in contact with the parents, who describe what they see and pass on their concerns, and it is difficult to have direct contact ... |
To overcome the complexity of medical regulation, a number of tools and aids have been developed, including visio or video-regulation (regulation via the camera on the caller's smartphone). |
This device has been evaluated in a number of situations, enabling it to take its place in the daily practice of many doctors, but there is very little data concerning pediatric visio-regulation, particularly with regard to dyspnea. |
To the best of the investigator knowledge, there is no prospective study looking at the impact of Video-Regulation on the outcome of patients requiring the advice of SAMU Centre-15 for pediatric dyspnea. conditions: Pediatric Respiratory Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROS... |
<|newrecord|> nctId: NCT06335927 id: GWK2023-001 briefTitle: HAIC Combined With Cadonilimab and Regorafenib as 2nd-line Treatment for ICC overallStatus: RECRUITING date: 2023-05-11 date: 2025-05-10 date: 2026-05-10 date: 2024-03-28 date: 2024-03-28 name: Fudan University class: OTHER briefSummary: This study is a singl... |
The study plans to enroll approximately 45 participants. All enrolled participants will receive continuous treatment: HAIC-Gemox: Gemcitabine 1000mg/m2 on Day 1 + Oxaliplatin 85mg/m2 on Day 1, every 3 weeks (Q3W), for up to 6 treatment cycles, Cadonilimab(6mg/kg, D2, Q3W) and Regorafenib (80mg QD, Q3W) until the invest... |
<|newrecord|> nctId: NCT06335914 id: dualPET-mPC id: CAPCR: 23-5595 type: OTHER domain: University Health Network briefTitle: Dual PSMA and FDG PET Imaging for Patients With Advanced Prostate Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2029-03-04 date: 2029-09-04 date: 2024-03-28 date: 2024-03-28 na... |
<|newrecord|> nctId: NCT06335901 id: xx20190901 briefTitle: Clinical Characteristics and Outcomes of Coronary Heart Disease overallStatus: COMPLETED date: 2020-02-01 date: 2022-01-31 date: 2022-04-30 date: 2024-03-28 date: 2024-03-29 name: Xinjiang Medical University class: OTHER briefSummary: This study evaluated and ... |
<|newrecord|> nctId: NCT06335888 id: CRAFT briefTitle: A Clinical Trial to Investigate 18F-AzaFol in the Diagnosis of Large Vessel Vasculitis acronym: CRAFT overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2029-05 date: 2029-05 date: 2024-03-28 date: 2024-04-05 name: Insel Gruppe AG, University Hospital Bern class... |
Participants will undergo AzaFol-PET/CT imaging at a single timepoint. conditions: Giant Cell Arteritis studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Cross-over, randomized, open label, single-centre primaryPurpose: DIAGNOSTIC masking: NONE co... |
<|newrecord|> nctId: NCT06335875 id: HUM00227568 briefTitle: Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones acronym: BIPO overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2027-03 date: 2027-03 date: 2024-03-28 date: 2024-03-28 name: University of Michigan class: OTHER briefSummary: Small expl... |
<|newrecord|> nctId: NCT06335862 id: NL.84862.041.23 briefTitle: Primary Posterior Tracheopexy Prevents Tracheal Collapse acronym: PORTRAIT overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-09-30 date: 2027-03-31 date: 2024-03-28 date: 2024-03-28 name: UMC Utrecht class: OTHER name: For Wis(h)dom Foundation... |
Methods: This is an international multicentre double-blind randomised controlled trial. Seventy eight children with OA type C will be included. Patients will be included after written parental informed consent. Half of the patients will be randomly allocated to the PPT-group and half to the no-PPT-group. The degree and... |
Risks and burden: Since OA correction with PPT (more recently implemented in centres of expertise) and without PPT (wait-and-see policy) are both accepted and safe treatment options, participating in the trial does not pose an increased risk or burden with regards to the treatment. Performing tracheobronchoscopies may ... |
<|newrecord|> nctId: NCT06335849 id: LYB004-CT-AUS-101 briefTitle: A Safety and Immunogenicity Trial of the Recombinant Zoster Vaccine （CHO Cell）, LYB004 in Adults Aged 50 to 70 Years overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-02 date: 2025-05 date: 2024-03-28 date: 2024-03-28 name: Guangzhou Patronus B... |
<|newrecord|> nctId: NCT06335836 id: 2024-SR-127 id: 2024-SR-127 type: OTHER domain: Ethics Committee of Nanjing Medical University briefTitle: The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD) overallStatus: RECRUITI... |
1. To explore the association between social isolation and lonely SCD populations and the occurrence and progression of MCI and AD through cross-sectional studies, cohort studies and randomized controlled trials of SCD; |
2. To clarify the correlation between different carrier states, resting brain function connectivity characteristics, and dual-task walking ability of APOEε4 allele and the progression of SCD to MCI and AD during the cognitive progress of people with SCD affected by social isolation; |
3. Establish a predictive model of cognitive decline from SCD to MCI and AD, and apply it to the SCD population to carry out individualized interventions; |
4. Confirm the protective effect of social interaction on cognitive level and brain function in SCD patients. conditions: Social Isolation conditions: SCD conditions: Subjective Cognitive Decline conditions: MCI conditions: Mild Cognitive Impairment conditions: AD conditions: Alzheimer Disease studyType: OBSERVATIONAL ... |
<|newrecord|> nctId: NCT06335823 id: STUDY20231621 briefTitle: Efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Reduction During Intrauterine Device (IUD) Insertion in Outpatient Gynecology overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-08-01 date: 2025-08-01 date: 2024-03-28 date:... |
<|newrecord|> nctId: NCT06335810 id: 23-10026599 id: R01DK135949-01 type: NIH link: https://reporter.nih.gov/quickSearch/R01DK135949-01 briefTitle: Reducing Obesity Using Social Ties Program acronym: ROBUST overallStatus: RECRUITING date: 2024-04-05 date: 2026-03 date: 2026-03 date: 2024-03-28 date: 2024-04-17 name: We... |
<|newrecord|> nctId: NCT06335797 id: IRB00110733 briefTitle: Optimization of Postoperative Bowel Habits overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-06 date: 2025-12 date: 2024-03-28 date: 2024-03-28 name: Wake Forest University Health Sciences class: OTHER briefSummary: Project is a trial, in which women... |
<|newrecord|> nctId: NCT06335784 id: 2023-00456 briefTitle: Mental Imagery and Targeted Memory Reactivation in Insomnia overallStatus: RECRUITING date: 2024-04-22 date: 2027-05-31 date: 2027-08-31 date: 2024-03-28 date: 2024-04-23 name: University Hospital, Geneva class: OTHER name: University of Geneva, Switzerland br... |
Patients with ID will be randomized into four groups: in the first group (SH group), patients will have 4 weekly sessions (1 session/week) of a minimal intervention for insomnia (sleep hygiene information) in the presence of an odorless diffuser, which will be also used during the night. In the second group (IR group),... |
Clinical evaluation of insomnia severity before and after the intervention will take place using the Insomnia Severity Index (ISI, primary outcome measure). |
At the end of these interventions, patients with persistent symptoms will benefit from an alternative experimental treatment ("rocking bed") in which they will be cradled for one night. |
The investigators hypothesize that patients treated with IR will have significantly reduced insomnia severity compared to participants who received a minimal intervention. They also hypothesize that patients of the TMR group, will have more reduced ID severity compared to participants performing IR and with an odorless... |
<|newrecord|> nctId: NCT06335771 id: 2098077 id: R01DK131188 type: NIH link: https://reporter.nih.gov/quickSearch/R01DK131188 briefTitle: Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity acronym: ATM overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2028-03 date: 2028-03 date: 2024-03-28 date: 2024-03-28... |
Both groups will have: |
* screening visit |
* imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) |
* Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies Participants with obesity will complete meetings with study team members for a weight loss intervention to achieve a 10% body weight loss. conditions: Obesity conditions: Nonalcoholic Fatty Liver conditions: Diabetes Type 2 conditions: He... |
<|newrecord|> nctId: NCT06335758 id: EXC-039-2023-CLR briefTitle: Non-randomized Observational Study to Evaluate ReX® in the Management of Solid Oral Medication. acronym: RegStud overallStatus: RECRUITING date: 2024-01-15 date: 2025-12-31 date: 2026-01-31 date: 2024-03-28 date: 2024-03-28 name: Dosentrx Ltd. class: IND... |
The study will evaluate and monitor use of ReX in respect of: |
* treatment duration |
* adverse events |
* patient adherence and compliance |
* engagement with ReX via patient-reported outcomes |
Patients participating in the study will receive their normal medication as standard of care via ReX. Progress will be monitored via patients' responses to questions presented on the ReX touch screen. conditions: Any Solid Oral Medication studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTI... |
<|newrecord|> nctId: NCT06335745 id: 24-066 briefTitle: PediCARE Health Equity Intervention in High-Risk Neuroblastoma overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2028-04-01 date: 2030-04-01 date: 2024-03-28 date: 2024-03-28 name: Dana-Farber Cancer Institute class: OTHER briefSummary: This is a randomized Ph... |
The names of the intervention groups in this research study are: |
* Usual supportive care |
* PediCARE + usual supportive care conditions: Neuroblastoma conditions: High-risk Neuroblastoma conditions: Pediatric Cancer conditions: Disparities conditions: Financial Stress conditions: Poverty studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE m... |
<|newrecord|> nctId: NCT06335732 id: P.T.REC/012/004394 briefTitle: Prevalenc Of Lumbosacral Radiculopathy Among Physiotherapists Of Pediatric Rehabilitation OF PEDIATRIC REHABILITATION overallStatus: COMPLETED date: 2022-12-05 date: 2023-06-08 date: 2023-08-22 date: 2024-03-28 date: 2024-03-28 name: Kerolous Ishak She... |
<|newrecord|> nctId: NCT06335719 id: IRB #22-926 briefTitle: Intraoperative Electrical Stimulation to Improve Nerve Grafting Outcome overallStatus: RECRUITING date: 2023-03-01 date: 2025-03 date: 2025-06 date: 2024-03-28 date: 2024-03-28 name: The Cleveland Clinic class: OTHER briefSummary: A research study to find out... |
Other 1/3 of study participants will undergo the surgery as they normally would if they had not chosen to participate. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: This is a randomized, controlled, double-blinded (patient and evaluator) prospective study. Plan is to enroll up to 30 patients, with a min... |
<|newrecord|> nctId: NCT06335706 id: 0596/66 briefTitle: The Influence of Fit of Underpants Worn on Semen Quality overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-05 date: 2024-05 date: 2024-03-28 date: 2024-03-28 name: Chulalongkorn University class: OTHER briefSummary: The goal of this observational study i... |
* Assessing the effect of underpants fit on basic semen parameters and sperm DNA integrity. |
* Determining the prevalence of preferred type of underpants worn by Thai males. |
The participants will need to provide informed consent, complete a questionnaire consisting of 28 questions, and provide a semen sample. conditions: Infertility, Male conditions: Semen Analysis studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 120 type: ESTIMATED name: Fit of un... |
<|newrecord|> nctId: NCT06335693 id: CHHHospital briefTitle: Adjuvant Hypofractionated Radiotherapy for Prostate Cancer overallStatus: RECRUITING date: 2024-03-28 date: 2026-02-28 date: 2027-02-28 date: 2024-03-28 date: 2024-03-28 name: Changhai Hospital class: OTHER briefSummary: Hypofractionated radiation therapy is ... |
<|newrecord|> nctId: NCT06335680 id: 21-001493 briefTitle: [Trial of device that is not approved or cleared by the U.S. FDA] overallStatus: WITHHELD date: 2024-03-28 date: 2024-03-28 name: [Redacted] hasResults: False |
<|newrecord|> nctId: NCT06335667 id: 4565 id: UCI 23-72 type: OTHER domain: UCI CFCCC briefTitle: mpMRI Compared to Diagnostic TURBT in Patients With Suspected Muscle-Invasive Bladder Cancer Objectives overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2030-04 date: 2024-03-28 date: 2024-03-28 name: Un... |
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