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<|newrecord|> nctId: NCT06333379 id: SichuanPPHLC04 id: 2020LY01 type: OTHER_GRANT domain: Sichuan Provincial People's Hospital briefTitle: Aspergillosis Detection Via EBC-GM in Ventilated Patients overallStatus: COMPLETED date: 2023-01-02 date: 2023-12-30 date: 2024-01-10 date: 2024-03-27 date: 2024-03-27 name: Lin Ch... |
Objective: To evaluate the diagnostic accuracy of measuring GM levels in EBC for detecting IPA in mechanically ventilated patients, comparing it against the conventional Bronchoalveolar Lavage Fluid (BALF)-GM measurements. |
Methods: A clinical trial will be conducted with 75 mechanically ventilated patients suspected of having IPA. The study will compare the effectiveness of EBC-GM levels against BALF-GM levels in diagnosing IPA, focusing on sensitivity, specificity, and diagnostic accuracy. The novel, self-designed EBC collection device ... |
Expected Outcomes: |
Validation of EBC-GM Diagnostic Accuracy: Anticipate demonstrating that EBC-GM levels provide a comparable diagnostic accuracy to BALF-GM, establishing a non-invasive, safer alternative for IPA detection. |
Implementation of a Non-Invasive Diagnostic Tool: The study aims to introduce a non-invasive diagnostic approach that can potentially replace more risky, invasive methods, improving patient care in ICUs. |
Contribution to Clinical Practice: By providing a new method for early and safer detection of IPA, the study is expected to influence clinical guidelines and practices in the management of critically ill, ventilated patients. |
Significance: This research has the potential to revolutionize the diagnosis of fungal infections in critically ill patients by offering a non-invasive, accurate, and safer diagnostic tool, thereby improving patient outcomes and reducing the risks associated with invasive diagnostic procedures. conditions: Bronchoalveo... |
<|newrecord|> nctId: NCT06333366 id: 202301590A0C501 id: Application No.2402020052 type: OTHER domain: Chang Gung Memorial Hospital briefTitle: First-In-Human Study of PDT to Detect IAH overallStatus: RECRUITING date: 2024-02-18 date: 2024-07-16 date: 2025-09-20 date: 2024-03-27 date: 2024-03-27 name: Chang Gung Memori... |
<|newrecord|> nctId: NCT06333353 id: H-06-23-9278 briefTitle: Is Repetitive Transcranial Magnetic Stimulation Effective in Reducing Endometriosis-associated Pain overallStatus: RECRUITING date: 2024-04-12 date: 2027-05-20 date: 2027-06-20 date: 2024-03-27 date: 2024-04-15 name: University of Ottawa class: OTHER briefSu... |
The objectives of this trial are: |
1. to evaluate the effectiveness of an rTMS intervention for pain reduction among those with recalcitrant post-operative EAP, |
2. to inform on the utility of a long (10 session) vs short (5 session) protocol for pain reduction among those with recalcitrant post-operative EAP |
3. to determine if any improvements in pain observed 30 days after an rTMS intervention are retained 6 months later |
4. to identify physical and psychosocial mediators that impact the successful reduction of pain among patients with EAP treated using rTMS. |
5. to describe patients' perceptions of and satisfaction with rTMS as an intervention for EAP. conditions: Endometriosis conditions: Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Parallel Assignment primaryPurpose: TREATMENT masking: QUADRUPLE... |
<|newrecord|> nctId: NCT06333340 id: 24-03 briefTitle: Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-03 date: 2025-03 date: 2024-03-27 date: 2024-04-12 name: Samuel L... |
This trial will focus on patients that are at increased risk of PPH, with risk factors such as: multiple gestation (twins, or more multiples), large baby, polyhydramnios (excess amniotic fluid), history of PPH, body mass index greater than 40, diabetes mellitus, hypertension, and placenta previa. |
The investigators hypothesize that carbetocin would be more effective than an oxytocin regimen in reducing the risk of PPH in patients undergoing CD with any of the biological high-risk factors. conditions: Post Partum Hemorrhage studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL pr... |
<|newrecord|> nctId: NCT06333327 id: 1432022000278 briefTitle: Multicenter Registry of Atrial Fibrillation Ablation With Radiofrequency Balloon Catheter acronym: COLLABORATE overallStatus: RECRUITING date: 2021-01-01 date: 2030-01-01 date: 2030-12-01 date: 2024-03-27 date: 2024-03-27 name: Universitair Ziekenhuis Bruss... |
<|newrecord|> nctId: NCT06333314 id: UC-IMM-2302 briefTitle: Dostarlimab for Locally Advanced or Metastatic Cancer (Non-colorectal/Non-endometrial) With Tumor dMMR/MSI acronym: Pan-MSI-ACSE overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-10 date: 2030-09 date: 2024-03-27 date: 2024-03-29 name: UNICANCER clas... |
Adult patients (aged ≥18 years) with histologically confirmed dMMR/MSI duodenum and small bowel adenocarcinoma, gastric and oeso-gastric junction (OGJ) adenocarcinoma with combined positive score (CPS)\<5, pancreatic adenocarcinoma, ampulla of vater adenocarcinoma, adrenocortical carcinoma, carcinoma of unknown primary... |
Patients with documented disease progression following the first line chemotherapy (Arm B) may be eligible for crossover to be treated with dostarlimab, with the same schedule as arm A. conditions: Pancreatic Adenocarcinoma conditions: Ampulla of Vater Carcinoma conditions: Adrenocortical Carcinoma conditions: Neuroend... |
<|newrecord|> nctId: NCT06333301 id: TIME-ZZZ briefTitle: Translational Initiative to Map Epigenetics in Sleep acronym: TIME-ZZZ overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2034-04 date: 2034-04 date: 2024-03-27 date: 2024-03-27 name: Elysium Health class: INDUSTRY name: University of Oxford briefSummary: The... |
<|newrecord|> nctId: NCT06333288 id: 2024-0268 briefTitle: Pilot Trial to Evaluate PROblem Solving Therapy and APPLE Watch for College Students overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-11-30 date: 2025-03-30 date: 2024-03-27 date: 2024-03-27 name: University of Illinois at Chicago class: OTHER brie... |
<|newrecord|> nctId: NCT06333275 id: DLF-Nr: 5564 id: BASEC-Nr: 2023-01141 type: OTHER domain: BASEC (Business Administration System for Ethics Committees) - Switzerland briefTitle: Restoration of Immunity to Vaccine Preventable Diseases After CART-T Cell Therapy acronym: IMCAR overallStatus: RECRUITING date: 2023-11-1... |
* Do CAR-T cell therapy recipients lose vaccine protection against common vaccine-preventable pathogens |
* Are current re-vaccination recommendations sufficient in restoring vaccine-protection |
* Is this restored vaccine-protection after CAR-T cell therapy lost faster than usual |
* Do clinical or immunological factors predict vaccine response after CAR-T cell therapy conditions: Vaccine Immunity in CAR-T Cell Therapy Recipients studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 80 type: ESTIMATED name: Vaccines against: Diphtheria, tetanus, pertussis, polio,... |
<|newrecord|> nctId: NCT06333262 id: 24-017 briefTitle: Fixed Duration Pirtobrutinib and Obinutuzumab in Chronic Lymphocytic Leukemia overallStatus: RECRUITING date: 2024-04 date: 2027-02-01 date: 2029-02-01 date: 2024-03-27 date: 2024-04-23 name: Inhye Ahn class: OTHER name: Loxo Oncology, Inc. briefSummary: This stud... |
<|newrecord|> nctId: NCT06333249 id: AGTC-RPGR-001 SKYLINE briefTitle: A Study Comparing Two Doses of AGTC-501 in Male Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (SKYLINE) overallStatus: ACTIVE_NOT_RECRUITING date: 2021-04-13 date: 2023-04-11 date: 2027-02 date: 2024-03-27 date: 2024-03-27 nam... |
Approximately 12 subjects who meet the inclusion criteria, will be randomized in a 1:1 ratio to 1 of 2 treatment groups. Each subject will receive the assigned dose of AGTC-501 in the study eye; no treatment will be administered in the fellow eye. As treatment outcomes in pediatric vs. adult subjects may differ, random... |
Each subject will receive a central subretinal injection of AGTC-501 at the assigned dose in the central macula of the study eye. primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: The Phase 2 study is a masked study; therefore, neither the investigator nor the subject will know the dose assignment. Both ... |
<|newrecord|> nctId: NCT06333236 id: OCU_KRON briefTitle: Effect of Kron (Citicoline and Nicotinamide Oral Solution) on Patients With Open-angle Glaucoma overallStatus: NOT_YET_RECRUITING date: 2024-03-25 date: 2024-09-30 date: 2024-11-30 date: 2024-03-27 date: 2024-03-27 name: ASST Santi Paolo e Carlo class: OTHER bri... |
<|newrecord|> nctId: NCT06333223 id: LSC 23/ 396 briefTitle: Polyphenols and Probiotics to Improve Menopausal Symptoms Via the Gut-Brain Axis acronym: SYMPTOGUT overallStatus: RECRUITING date: 2024-03-18 date: 2024-12-18 date: 2025-03-30 date: 2024-03-27 date: 2024-03-29 name: University of Roehampton class: OTHER name... |
To our knowledge, the efficacy of a (poly)phenol based synbiotic targeting the gut microbiome for improvement of menopausal symptoms has not been investigated so far. conditions: Menopause studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Arm 1: Mixtu... |
<|newrecord|> nctId: NCT06333210 id: BCD-180-3 briefTitle: Study of the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of BCD-180 in Patients With Axial Spondyloarthritis (LEVENTA) overallStatus: RECRUITING date: 2023-12-25 date: 2024-12 date: 2028-02 date: 2024-03-27 date: 2024-03-27 name: Biocad class: INDUS... |
<|newrecord|> nctId: NCT06333197 id: Mandibular condylar fracture briefTitle: Approaches for Open Reduction and Internal Fixation of Mandibular Condylar Fracture overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03-01 date: 2025-07-01 date: 2024-03-27 date: 2024-03-28 name: Assiut University class: OTHER br... |
Condylar fractures constitute 25.5% to 35.5% of all mandibular fractures. The mandibular condyle fracture is a type of fracture that affects the condyle, which is the knuckle-like projection of the mandible (lower jaw) that articulates with the temporal bone to form the temporomandibular joint (TMJ). conditions: Mandib... |
<|newrecord|> nctId: NCT06333184 id: 3085-4215 briefTitle: Smoothies and Blood Sugars overallStatus: RECRUITING date: 2024-03-20 date: 2024-08-31 date: 2024-12-31 date: 2024-03-27 date: 2024-03-27 name: University of Bath class: OTHER briefSummary: Glycaemic responses to fruit smoothies may depend on the food matrix (e... |
<|newrecord|> nctId: NCT06333171 id: 00003872 briefTitle: 4-aminopyridine for Skin Wound Healing overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2027-09 date: 2028-03 date: 2024-03-27 date: 2024-03-27 name: John Elfar class: OTHER briefSummary: Many patients suffer from chronic non-healing wounds as well as acute... |
The purpose of this study is to evaluate the role of 4-AP on the treatment of wounds to accelerate healing. |
The investigational treatment will be used to test the hypothesis that 4-AP can speed wound healing. conditions: Wounds conditions: Wound of Skin conditions: Wound Heal conditions: Wounds and Injuries studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescriptio... |
<|newrecord|> nctId: NCT06333158 id: AmWaRO Study briefTitle: Extracts of Amla, Walnut Leaf, Red Yeast Rice and Olive in Cardiovascular Prevention acronym: AmWaRO overallStatus: RECRUITING date: 2024-03-01 date: 2024-09 date: 2024-12 date: 2024-03-27 date: 2024-03-27 name: Nina Hermans class: OTHER name: University Hos... |
1. Leads to a clinically relevant reduction of cholesterol levels, especially LDL, |
2. Leads to a clinically relevant reduction of blood pressure on the short term, |
3. Leads to a change in oxidative stress biomarkers. |
Participants will be stratified by sex before randomization to one of the two treatments for 8 weeks: |
* Cholesfytol NG: 500 mg Amla dry extract, 50 mg Walnut leaf dry extract, 33.6 mg Red yeast rice powder (equivalent to 1.45 mg monacolins), 25 mg Olive dry extract (equivalent to 5 mg of hydroxytyrosol) per day |
* Placebo All treatments have an identical shape and color and should be used in the same way (oral intake; 3 capsules/day during dinner). No dietary instructions are given and participants are asked not to change their dietary habits, not to start other therapies (medication, supplements, slimming diets, extra physica... |
<|newrecord|> nctId: NCT06333145 id: EDRA briefTitle: ED90 of Remimazolam Anesthesia Induction in Drug-induced Sleep Endoscopy in Adults overallStatus: RECRUITING date: 2024-02-04 date: 2024-12-31 date: 2024-12-31 date: 2024-03-27 date: 2024-03-27 name: Tongji Hospital class: OTHER briefSummary: Exploring the ED90 of r... |
<|newrecord|> nctId: NCT06333132 id: DiabEAT.it briefTitle: Deciphering the Role of Incretin Hormones in Weight Loss-induced Remission of Type 2 Diabetes (DIABeat) acronym: DiabEATit overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2025-09-01 date: 2026-02-01 date: 2024-03-27 date: 2024-03-27 name: Azienda Ospe... |
<|newrecord|> nctId: NCT06333119 id: 72867572-050.01.04-320 briefTitle: The Relationship Between Urinary Incontinence and Motor Symptoms overallStatus: COMPLETED date: 2023-09-01 date: 2024-01-31 date: 2024-02-15 date: 2024-03-27 date: 2024-03-27 name: Pinar Yasar class: OTHER briefSummary: There is no study in the lit... |
<|newrecord|> nctId: NCT06333106 id: FICUS - 2024/16FEV/077 briefTitle: PoCUS Diagnostic Accuracy for Fecal Impaction in the Emergency Department: A Prospective Study overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-27 date: 2024-04-29 name: Cliniques universitaires Sai... |
<|newrecord|> nctId: NCT06333093 id: NL82178.018.22 briefTitle: Duodenal tIssue ResEction aCquisiTion (DIRECT) Study acronym: DIRECT overallStatus: RECRUITING date: 2023-01-10 date: 2024-06-01 date: 2024-06-01 date: 2024-03-27 date: 2024-03-27 name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) clas... |
<|newrecord|> nctId: NCT06333080 id: N-20220017 briefTitle: The Effect of Adherence to Oral Semaglutide on Glycaemic Control in People With Type 2 Diabetes Treated With Metformin acronym: DIACRON overallStatus: RECRUITING date: 2024-05-01 date: 2025-03 date: 2025-03 date: 2024-03-27 date: 2024-03-27 name: Aalborg Unive... |
<|newrecord|> nctId: NCT06333067 id: Sofwave21 briefTitle: Treatment to Lift Facial Lax Skin and Improve Facial Wrinkles Using Precise and Lift Applicators overallStatus: RECRUITING date: 2023-10-11 date: 2024-10-01 date: 2024-11-01 date: 2024-03-27 date: 2024-03-27 name: Sofwave Medical LTD class: INDUSTRY briefSummar... |
<|newrecord|> nctId: NCT06333054 id: NCLIN0091/ 14ct/mp37li briefTitle: Safety and Efficacy of a Head Lice Shampoo overallStatus: COMPLETED date: 2014-10-13 date: 2015-06-08 date: 2015-06-08 date: 2024-03-27 date: 2024-03-27 name: Oystershell NV class: INDUSTRY briefSummary: This study is designed to compare the effect... |
<|newrecord|> nctId: NCT06333041 id: 32977-01-00 briefTitle: Study of Cannabidiol in Sanfilippo Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-01 date: 2027-05 date: 2024-03-27 date: 2024-04-19 name: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center class: OTHER briefSumma... |
Each participant's caregiver will be asked to complete surveys related to the participant's behavior, mood, sleep, stooling, pain, and caregiver stress intermittently throughout the study. All participants will be enrolled into one of two cohorts based on enrollment order: |
1. Sentinel Safety Cohort (first 5 participants) - all participants treated with Epidiolex (cannabidiol) |
2. Controlled Cohort (next 30 participants) - participants randomized 1:1 (equal chance) to start treatment with Epidiolex (cannabidiol) or placebo for 16 weeks, followed by an 8-week washout period (no treatment). Participants then switch to the opposite treatment group for 16 weeks followed by all participants treate... |
<|newrecord|> nctId: NCT06333028 id: 938 briefTitle: A Study to Evaluate the enVista® Aspire (EA) Intraocular Lens in Subjects Undergoing Cataract Extraction overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-09 date: 2024-09 date: 2024-03-27 date: 2024-04-29 name: Bausch & Lomb Incorporated class: INDUSTRY bri... |
<|newrecord|> nctId: NCT06333015 id: 924 briefTitle: Study to Evaluate the Safety and Effectiveness of the enVista® Beyond (EY) EDF Intraocular Lens in Subjects Undergoing Cataract Extraction overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-10 date: 2025-10 date: 2024-03-27 date: 2024-04-29 name: Bausch & Lom... |
<|newrecord|> nctId: NCT06333002 id: PI24/00325 briefTitle: Machine Learning Model to Predict Outcome and Duration of Mechanical Ventilation in Acute Hypoxemic Respiratory Failure acronym: MEMORIAL overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-19 date: 2026-05-30 date: 2026-05-30 date: 2024-03-27 date: 2024-03-27 ... |
<|newrecord|> nctId: NCT06332989 id: N22.129 briefTitle: Stroke Triage Optimization by Ambulance Paramedics in the Pre-hospital Setting acronym: STROKE-APP overallStatus: RECRUITING date: 2024-02-01 date: 2027-02-01 date: 2027-02-01 date: 2024-03-27 date: 2024-03-27 name: Leiden University Medical Center class: OTHER n... |
<|newrecord|> nctId: NCT06332976 id: IEO 1521 briefTitle: PrefeRences And ChemoTherapy In Breast Cancer patiEnts acronym: PRACTICE overallStatus: RECRUITING date: 2021-06-04 date: 2024-12-31 date: 2024-12-31 date: 2024-03-27 date: 2024-03-27 name: European Institute of Oncology class: OTHER briefSummary: The aim of the... |
The benefit should be evaluated in terms of Survival rate trade off and Survival time trade off value. The analyses will be conducted into three different groups of patients to value the survival benefit expected: |
1. before to start the chemotherapy |
2. during chemotherapy |
3. after the end of chemotherapy conditions: Female Breast Cancer studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 450 type: ESTIMATED name: Completion of questionnaires measure: Percentage of risk reduction needed to consider adjuvant or neoadjuvant chemotherapy worthwhile measure... |
<|newrecord|> nctId: NCT06332963 id: 2023-007 briefTitle: Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-06 date: 2028-12 date: 2024-03-27 date: 2024-03-27 name: Laureate Institute for Brain Research, Inc. class: OTHER briefSummary: The ... |
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