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1. Does postoperative dexmedetomidine reduce the incidence of delirium after lung surgery? |
2. Does postoperative dexmedetomidine introduce other medical problems? Researchers will compare dexmedetomidine and sufentanil to see if dexmedetomidine works to reduce delirium. |
Participants will undergo routine postoperative care: |
1. Patient-controlled self anesthesia with sufentanil only or combination of sufentanil and dexmedetomidine |
2. Postoperative visit twice a day for at least seven days conditions: Delirium in Old Age conditions: Anesthesia; Adverse Effect studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR co... |
<|newrecord|> nctId: NCT06382948 id: MedOPP545 id: 2024-512926-27-00 type: CTIS briefTitle: Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i. acronym: ADELA overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-09 date: 2028-04 date: 2024-04-24 date: 202... |
The main purpose of the study is to analyze the efficacy (to find out how effective a treatment is) of elacestrant plus everolimus therapy in patients who have ER-positive/HER2-negative, ESR1-mutated, ABC progressing to endocrine therapy and cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. The efficacy of elacestrant pl... |
Rigorous eligibility criteria based on specific co-morbidities and clinicopathologic features of their disease have been designed to minimize the risk of patients participating in this study. The anticipated favorable clinical benefits of elacestrant combined with everolimus are projected to outweigh the risks of this ... |
<|newrecord|> nctId: NCT06382935 id: 34-24 briefTitle: Impact of Non-surgical Periodontal Treatment of miRNome overallStatus: RECRUITING date: 2024-04-20 date: 2024-09-22 date: 2024-10-15 date: 2024-04-24 date: 2024-04-24 name: University of Catania class: OTHER briefSummary: A double-blind randomized-controlled clinic... |
<|newrecord|> nctId: NCT06382922 id: PAPAML022019 briefTitle: Role of Antifungal Prophylaxis in Elderly Patients With Acute Myeloid Leukemia During Consolidation Therapy overallStatus: RECRUITING date: 2023-03-29 date: 2024-07-30 date: 2025-06-01 date: 2024-04-24 date: 2024-04-29 name: University of Rome Tor Vergata cl... |
The investigators also observed that centers involved in this survey had different antifungal policies during the AML consolidation phase. The results from this study show that in a large real-world setting the mold active PAP, with itraconazole or posaconazole, decreases the rate of IA after consolidation course. |
In SEIFEM 2016 study the investigators demonstrated that the incidence of IA during the AML consolidation is low. However, the mortality is not negligible, mainly in older patients. Further, a sub-analysis in the subset of patients older than 60 years demonstrated that patients who didn't receive mold active prophylaxi... |
<|newrecord|> nctId: NCT06382909 id: 202302 briefTitle: Effect of Probiotic Compound K11T e K11TMax in ASD acronym: ASD overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-22 date: 2024-07-07 date: 2025-04-07 date: 2024-04-24 date: 2024-04-29 name: Deivis de Oliveira guimaraes class: NETWORK name: SENAI CIMATEC briefSum... |
<|newrecord|> nctId: NCT06382896 id: FirstAHXiamenU-YB-2 briefTitle: Effect of Oliceridine on Rebound Pain overallStatus: RECRUITING date: 2024-01-01 date: 2025-12-31 date: 2025-12-31 date: 2024-04-24 date: 2024-04-25 name: The First Affiliated Hospital of Xiamen University class: OTHER briefSummary: The purpose of thi... |
<|newrecord|> nctId: NCT06382883 id: FINELO2024 briefTitle: Lifestyle and Physical Activity as Part Of Obstructive Sleep Apnea Treatment acronym: ELO overallStatus: RECRUITING date: 2024-04-22 date: 2026-07-31 date: 2026-07-31 date: 2024-04-24 date: 2024-04-24 name: Filha ry class: OTHER name: University of Jyvaskyla n... |
The main questions the trial aims to answer are: |
* Can individually tailored lifestyle intervention, in combination with CPAP therapy, alleviate the severity or symptoms of OSA in overweight participants with moderate to severe OSA? |
* Does the addition of an individually tailored lifestyle intervention to CPAP therapy improve the quality of life, increase physical functioning, change body composition, and increase physical activity levels or decrease sedentary behavior of participants diagnosed with moderate to severe OSA? |
* Can enhanced behavioral support (EBS), when integrated with lifestyle intervention and CPAP therapy, lead to more substantial and enduring changes in participants' levels of physical activity or sedentary behavior? |
Participants will be randomized to either SEMC-intervention group, combination of SEMC-intervention and EBS, or to a control group. |
In this study, it is hypothesized that participants receiving SEMC-intervention in combination with CPAP therapy will experience greater alleviation of OSA severity and symptoms, improve their quality of life, body composition and physical functioning, as well as increase physical activity levels and decrease their sed... |
<|newrecord|> nctId: NCT06382870 id: 107.2023fbu briefTitle: Simulation-Based Training for Child Neglect and Abuse overallStatus: NOT_YET_RECRUITING date: 2024-05-29 date: 2024-06-15 date: 2024-06-29 date: 2024-04-24 date: 2024-04-24 name: Fenerbahce University class: OTHER briefSummary: Child abuse and neglect is a br... |
Regarding the evaluation of child neglect and abuse, healthcare professionals should approach a child who presents with suspicious injuries, thinking that he or she may be abused. The key here is to be aware of the problem. Health professionals should carefully examine children and fulfill their responsibilities by ide... |
<|newrecord|> nctId: NCT06382857 id: 823779-MDF Niger briefTitle: Effectiveness of a Microbiome-directed Food to Promote Programmatic and Sustained Nutritional Recovery Among Children With Uncomplicated Acute Malnutrition overallStatus: RECRUITING date: 2024-05-02 date: 2025-11-01 date: 2026-02-01 date: 2024-04-24 date... |
<|newrecord|> nctId: NCT06382844 id: PI23/00486 id: PI2023 08 1416 type: REGISTRY domain: Ethics Committee for Drug Research of the Salamanca Health Area briefTitle: Novel Flow-cytometry Approaches to Improve the Detection of Tumor Cells in CTCL overallStatus: RECRUITING date: 2024-01-01 date: 2026-09-30 date: 2026-12-... |
<|newrecord|> nctId: NCT06382831 id: IndonesiaU240201 briefTitle: Opioid Free Versus Opioid Balanced Anesthesia in Ophthalmic Surgery overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-08-01 date: 2024-10-01 date: 2024-04-24 date: 2024-04-24 name: Indonesia University class: OTHER briefSummary: Anesthesia wi... |
<|newrecord|> nctId: NCT06382818 id: PROICM 2023-10 PRO briefTitle: Personalization of Breast Radiotherapy According to Loco-regional Recurrence Risk and Toxicity Probability acronym: PROBA overallStatus: NOT_YET_RECRUITING date: 2024-04-26 date: 2027-04-26 date: 2036-04-26 date: 2024-04-24 date: 2024-04-24 name: Insti... |
* COHORT B = Low risk of recurrence / High risk of breast toxicity |
* COHORT C = High risk of recurrence / Low risk of breast toxicity |
* COHORT D = High risk of recurrence / High risk of breast toxicity primaryPurpose: TREATMENT masking: NONE count: 854 type: ESTIMATED name: COHORT A name: COHORT B name: COHORT C name: COHORT D measure: Rate of patients without any grade 2 or more fibrosis, nor radio-induced sarcoma measure: Acute toxicity measure: La... |
<|newrecord|> nctId: NCT06382805 id: HasanKU_FTR_AA_02 briefTitle: Comparison of the Effects of Kinesio Tape and High-intensity Laser Therapy in Lateral Epicondylitis overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-10-01 date: 2024-11-15 date: 2024-04-24 date: 2024-04-25 name: Hasan Kalyoncu University cl... |
<|newrecord|> nctId: NCT06382792 id: 2024PI059 briefTitle: Osteolysis of Allograft Prosthetic Composite After Shoulder Resection for Tumors overallStatus: ENROLLING_BY_INVITATION date: 2024-05-01 date: 2024-05-01 date: 2024-05-01 date: 2024-04-24 date: 2024-04-24 name: Central Hospital, Nancy, France class: OTHER brief... |
The results in these etiologies are good, and do not find any particular mechanical complications (including no osteolysis of the graft). In the case of reconstruction for cancer, the numbers of patients are lower (rare pathologies) and some studies on small numbers found osteolysis of the allograft. The aim of this st... |
<|newrecord|> nctId: NCT06382779 id: 2024PI057 briefTitle: Proximal Humerus Reconstruction After Resection for Tumors : Comparison Between Allograft Prosthetic Composite and Cement Sleeve Prosthetic Composite overallStatus: ENROLLING_BY_INVITATION date: 2024-04-15 date: 2024-05-01 date: 2024-05-01 date: 2024-04-24 date... |
<|newrecord|> nctId: NCT06382766 id: SMU in malnutrition briefTitle: Skeletal Muscle Ultrasonography in Detection of Malnutrition overallStatus: NOT_YET_RECRUITING date: 2025-03 date: 2026-03 date: 2026-03 date: 2024-04-24 date: 2024-04-24 name: Assiut University class: OTHER briefSummary: * To detect the role of Skele... |
* To assess the accuracy and validity of muscle ultrasonography in assessment of the nutritional status of critically ill child compared with other different nutritional assessment tools . conditions: Skeletal Muscle Ultrasonography studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL... |
<|newrecord|> nctId: NCT06382753 id: 20-24-PAR briefTitle: Impact of Periodontal Supportive Therapy in Patients With Gingivitis and Periodontitis overallStatus: RECRUITING date: 2024-04-20 date: 2024-06-30 date: 2024-06-30 date: 2024-04-24 date: 2024-04-24 name: University of Catania class: OTHER briefSummary: The stud... |
<|newrecord|> nctId: NCT06382740 id: AOP2097 briefTitle: Selection Protocol for Liver Transplantation in Patients Aged Over 70 Years acronym: Over70-LT overallStatus: RECRUITING date: 2022-10-01 date: 2025-10-01 date: 2025-10-01 date: 2024-04-24 date: 2024-04-24 name: Azienda Ospedaliera di Padova class: OTHER briefSum... |
This study proposes a "step by step" algorithm of selection for liver transplant candidates more than 70 years. conditions: End Stage Liver DIsease conditions: Liver Transplantation conditions: Old Age studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 18 type: ESTIMATED name: Liver... |
<|newrecord|> nctId: NCT06382727 id: ER008 briefTitle: CONTINUation of Enteral Nutrition Prior to Extubation Compared to Standard Care acronym: CONTINUE overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-24 date: 2024-04-24 name: Emma Ridley class: OTHER briefSummary: Critically i... |
The delivery of nutrition via EN is frequently interrupted due to procedures and changes in the gastrointestinal system that can cause digestion to be slow. One of the main contributors to EN interruptions is fasting prior to removal of the breathing tube (termed extubation). |
The practice of pausing EN prior to the removal of the breathing tube is historical and based on evidence for patients who are not within the ICU. There is currently no scientific consensus on whether pausing of EN is necessary, or for how long. Because of this, some clinicians choose to pause EN prior to removal of th... |
This study is a pilot randomised controlled trial of fasting patients for at least 4 hours prior to removal of the breathing tube compared with not pausing EN. The investigators hypothesise that this will reduce the number of hours of fasting in the 24 hours prior to extubation. conditions: Critical Illness studyType: ... |
<|newrecord|> nctId: NCT06382714 id: 2023-12/13 briefTitle: Virtual Museum Visit on Dialysis Symptoms and Anxiety in Hemodialysis Patients overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-08-30 date: 2024-12-31 date: 2024-04-24 date: 2024-04-24 name: Cumhuriyet University class: OTHER briefSummary: The mai... |
<|newrecord|> nctId: NCT06382701 id: Kayseri briefTitle: Effect of Aromatherapy on Pain, Anxiety and Satisfaction in Cannulation overallStatus: ACTIVE_NOT_RECRUITING date: 2021-09-06 date: 2024-06-30 date: 2024-06-30 date: 2024-04-24 date: 2024-04-24 name: TC Erciyes University class: OTHER briefSummary: The most activ... |
Patients participating in the study, researchers, and the nurse in charge will not know who is in the intervention and placebo groups. |
The research will be completed in twelve sessions over four weeks. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 60 type: ESTIMATED name: aromatherapy name: placebo measure: Visual Analog Scale (VAS) measure: State and Trait Anxiety Inventory (STAI) sex: ALL minimumAge: 18 Years maximum... |
<|newrecord|> nctId: NCT06382688 id: 23-08-0010 briefTitle: IV Administration of ChromaDex's Niagen® as Compared to NAD+ overallStatus: ACTIVE_NOT_RECRUITING date: 2023-11-13 date: 2024-03-08 date: 2024-08-31 date: 2024-04-24 date: 2024-04-24 name: Franklin Health Research class: OTHER briefSummary: This is a 2-part st... |
<|newrecord|> nctId: NCT06382675 id: TA-PF-01-DE id: CIV-23-11-044643 type: OTHER domain: Unique identification number EUDAMED briefTitle: Clinical Performance of the New Plasma Filter PX2 in TPE Treatments acronym: plasmaFlux overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-10 date: 2025-03 date: 2024-04-24 ... |
The investigation involves the collection of treatment data of the new Plasma Filter PX2 in combination with the multiFiltrate and multiFiltratePRO in therapeutic plasma exchange (TPE) treatments. The multiFiltrate and multiFiltratePRO are devices for extracorporeal blood purification treatments. No further control tre... |
<|newrecord|> nctId: NCT06382662 id: PMDAC-01 briefTitle: Effect of Metaxalone 640 mg (M640) on Truck Driving Ability and Cognition Compared to Other Skeletal Muscle Relaxants overallStatus: RECRUITING date: 2024-04-15 date: 2025-04-15 date: 2025-04-15 date: 2024-04-24 date: 2024-04-26 name: Primus Pharmaceuticals clas... |
<|newrecord|> nctId: NCT06382649 id: 202403051 briefTitle: Rivastigmine for Antimuscarinic Delirium acronym: RIVA-AM overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-07 date: 2026-07 date: 2024-04-24 date: 2024-04-25 name: Washington University School of Medicine class: OTHER name: American Academy of Clinica... |
Recent case reports and small observational studies suggest that rivastigmine might be useful in the treatment of AMD, but there is not direct prospective evidence comparing rivastigmine to physostigmine or supportive care. In order to investigate the effectiveness of rivastigmine, the investigators propose a randomize... |
<|newrecord|> nctId: NCT06382636 id: 23-101 briefTitle: Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes acronym: OPUS overallStatus: NOT_YET_RECRUITING date: 2024-05-31 date: 2027-02-28 date: 2027-02-28 date: 2024-04-24 date: 2024-04-24 name: The Cleveland Clinic class... |
Using data from NEST (Ensuring Patients Informed Access to NIPT \[non-invasive prenatal testing\]), the investigators designed the next iteration of NEST, a point-of care shared decision-making tool powered by artificial intelligence (AI) to provide a personalized and dynamic decision support tool: Obstetric Prenatal G... |
<|newrecord|> nctId: NCT06382623 id: 43 briefTitle: Efficacies of Different Managements in Patients With Trigger Finger overallStatus: COMPLETED date: 2022-10-01 date: 2023-06-30 date: 2023-06-30 date: 2024-04-24 date: 2024-04-24 name: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital class: ... |
<|newrecord|> nctId: NCT06382610 id: 2024-002 briefTitle: Pharmacokinetics of Melatonin Administered in Oral, Lotion, and Bubble Bath Formulations overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2024-12-15 date: 2024-12-15 date: 2024-04-24 date: 2024-04-24 name: University of Redlands class: OTHER briefSummary... |
<|newrecord|> nctId: NCT06382597 id: AWFiS/2024_2_P-GM briefTitle: Four Weeks of Nordic Hamstring Exercises Impact the Strength and Balance of the Hamstring Muscle Group overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-07-10 date: 2024-07-10 date: 2024-04-24 date: 2024-04-24 name: Gdansk University of Phys... |
<|newrecord|> nctId: NCT06382584 id: IRB_23.09.01 briefTitle: Impact of Treatment With Oral Anticoagulants of Patients With Fractures of the Upper End of the Femur acronym: ANTI_XA overallStatus: COMPLETED date: 2022-01-01 date: 2023-06-01 date: 2023-06-01 date: 2024-04-24 date: 2024-04-24 name: Centre Hospitalier Univ... |
In this context, the Nimes University Hospital receives a large number of elderly patients who have suffered a fracture of the end of the femur requiring surgery and who are taking anti Xa drugs.To avoid massive intra- and post-operative haemorrhage, surgical management is postponed because of the need to suspend the t... |
Before considering a prospective randomised study (early vs delayed surgery on AOD), we wish to retrospectively analyse data on patients admitted to the Nimes University Hospital on anti Xa and operated on for fracture of the upper end of the femur between 1 January 2022 and 1 June 2023 conditions: Direct Oral Anticoag... |
<|newrecord|> nctId: NCT06382571 id: 026/66 briefTitle: Factors Associated With Sub - Targeted Therapeutic Dose Of Renin - Angiotensin Blockage Among Chronic Heart Failure With Reduced Ejection Fraction Patients overallStatus: COMPLETED date: 2016-01-01 date: 2020-12-31 date: 2021-12-31 date: 2024-04-24 date: 2024-04-2... |
Methods: The retrospective cohort study was designed to collect data on Thai heart failure with reduced ejection fraction patients at Out-patient Clinic, Trat Hospital and Phrapokklao Hospital from January 2016 to December 2020. Thirteen factors were analyzed to determine their association with the sub-target group. co... |
<|newrecord|> nctId: NCT06382558 id: s68470 id: C2M/23/060 type: OTHER_GRANT domain: KU Leuven briefTitle: Validity and Reliability of Sensorimotor Processing Paradigm overallStatus: RECRUITING date: 2024-04-10 date: 2024-12-31 date: 2024-12-31 date: 2024-04-24 date: 2024-04-24 name: KU Leuven class: OTHER briefSummary... |
<|newrecord|> nctId: NCT06382545 id: Approval number 36.3.22 briefTitle: Post-instrumentation Pain After Use of the Fanta and M3 Pro Gold Systems overallStatus: COMPLETED date: 2021-11-01 date: 2022-06-30 date: 2022-07-30 date: 2024-04-24 date: 2024-04-24 name: Ahram Canadian University class: OTHER briefSummary: Compa... |
<|newrecord|> nctId: NCT06382532 id: AFMMUChina_NSRT briefTitle: Diagnosis of Depressive Disorder Malinger Using the Niacin Skin Response Test (NSRT) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-01 date: 2026-05-01 date: 2024-04-24 date: 2024-04-24 name: Air Force Military Medical University, China ... |
<|newrecord|> nctId: NCT06382519 id: Thal in VEOIBD briefTitle: Thalidomide Therapy for VEOIBD overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2025-12-31 date: 2026-12-31 date: 2024-04-24 date: 2024-04-24 name: Children's Hospital of Fudan University class: OTHER briefSummary: This is a single center, observat... |
<|newrecord|> nctId: NCT06382506 id: 2024/138 briefTitle: The Effect of Hazelnut Flour on Blood Glucose acronym: Hazelnut overallStatus: COMPLETED date: 2024-03-21 date: 2024-04-21 date: 2024-04-21 date: 2024-04-24 date: 2024-04-24 name: Ege University class: OTHER briefSummary: One of the factors affecting human healt... |
<|newrecord|> nctId: NCT06382493 id: B-2011-648-005 briefTitle: Tegoprazan-containing Sequential for H. Pylori overallStatus: RECRUITING date: 2021-02-01 date: 2024-12-12 date: 2024-12-12 date: 2024-04-24 date: 2024-04-24 name: Seoul National University Bundang Hospital class: OTHER briefSummary: As H. pylori eradicati... |
<|newrecord|> nctId: NCT06382480 id: 90/2023 briefTitle: PROTeIn-rich Meals to Control Glucose acronym: PROTIME overallStatus: RECRUITING date: 2024-04-12 date: 2026-12-31 date: 2027-02-28 date: 2024-04-24 date: 2024-04-24 name: German Institute of Human Nutrition class: OTHER name: Charite University, Berlin, Germany ... |
<|newrecord|> nctId: NCT06382467 id: 2401-136-016 briefTitle: Comparison of Remimazolam and Propofol Combination vs. Propofol in IOM overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-06 date: 2024-04-24 date: 2024-04-24 name: Chung-Ang University Gwangmyeong Hospital class: OTHER briefSummary: Th... |
<|newrecord|> nctId: NCT06382454 id: E2-23-5921 briefTitle: Upper Extremity Robot-Assisted Therapy in Stroke Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2025-03-30 date: 2025-03-30 date: 2024-04-24 date: 2024-04-24 name: Hacettepe University class: OTHER name: Interact Medical Technologies Inc. br... |
<|newrecord|> nctId: NCT06382441 id: KC/KE-23-0122/ER-4 briefTitle: A Tele-exercise Program for Breast Cancer Survivors overallStatus: ACTIVE_NOT_RECRUITING date: 2023-11-01 date: 2024-05-31 date: 2024-05-31 date: 2024-04-24 date: 2024-04-24 name: Hong Kong Baptist University class: OTHER briefSummary: The research pro... |
Breast cancer is identified as the most prevalent cancer among women globally and in Hong Kong. The document states that adjuvant therapies post-surgery, such as radiation and chemotherapy, can have both short-term and long-term side effects, which may affect the survivors' physical and mental health. |
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