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SHJ002 is an antisense oligonucleotide to neutralize a specific microRNA. conditions: Corneal Erosion studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Double-Blinded, Parallel, Vehicle-Controlled primaryPurpose: TREATMENT masking: QUADRUPLE maskin... |
<|newrecord|> nctId: NCT06381973 id: ELTGOL briefTitle: Ventilation Distribution in COPD Patients During Breathing Exercises overallStatus: RECRUITING date: 2024-04-15 date: 2024-08-01 date: 2024-08-01 date: 2024-04-24 date: 2024-04-25 name: William Poncin, PT, PhD class: OTHER briefSummary: ELTGOL (Slow Expiration wit... |
This study aimed to assess ventilation distribution in right lateral recumbency in patients with chronic obstructive pulmonary disease (COPD), as well as healthy individuals, and investigate the impact of thoracic and abdominal manual pressures during ELTGOL on ventilation distribution. conditions: Chronic Obstructive ... |
<|newrecord|> nctId: NCT06381960 id: 2022LJ014 briefTitle: Clinical Study on the Prevention and Treatment of Postoperative Metastasis of Lung Cancer by Fuzheng Quxie Recipe overallStatus: RECRUITING date: 2023-01-01 date: 2025-12-31 date: 2025-12-31 date: 2024-04-24 date: 2024-04-24 name: Jianhui Tian class: OTHER brie... |
<|newrecord|> nctId: NCT06381947 id: 19092023 briefTitle: Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients acronym: BESAFE overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-06-30 date: 2025-06-30 date: 2024-04-24 date: 2024-04-24 name: Universi... |
Bempedoic acid is an oral, once-daily prodrug, metabolized in the liver to an active inhibitor of ATP-citrate lyase, blocking cholesterol synthesis upstream of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and thereby increasing hepatic expression of the LDL receptor and decreasing circulating LDL-C levels. |
The CLEAR (Cholesterol Lowering via Bempedoic acid, an ACL-Inhibiting Regimen) Harmony trial demonstrated that bempedoic acid in addition to maximally tolerated statin therapy did not lead to a higher incidence of adverse events compared to placebo and significantly lowered LDL-C levels. In the CLEAR Serenity study, be... |
The synergistic effect of bempedoic acid plus PCSK9 inhibitors has been investigated by one phase 2 trial (NCT03193047), which showed a statistical superiority of bempedoic acid plus evolocumab strategy versus placebo plus evolocumab in terms of percent change in LDL-C up to 2 months. To date, no randomized phase 3 cli... |
The investigators hypothesized that the association of bempedoic acid with PCSK9 inhibitors and ezetimibe may be safe and effective in reducing LDL-C in statin-intolerant patients. conditions: Dyslipidemias conditions: Statin Adverse Reaction conditions: Cardiovascular Diseases conditions: Lipid Metabolism Disorders st... |
<|newrecord|> nctId: NCT06381934 id: 2024-00335; kt23ChristCrain4 briefTitle: Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-04 date: 2027-04 date: 2024-04-24 date: 2024-04-24 name: University ... |
<|newrecord|> nctId: NCT06381921 id: B2023-0046 briefTitle: Objective Integrated Multimodal Electrophysiological Index for the Quantification of Visceral Pain acronym: OIME overallStatus: NOT_YET_RECRUITING date: 2025-05-01 date: 2027-10-31 date: 2029-02-28 date: 2024-04-24 date: 2024-04-24 name: University of Connecti... |
<|newrecord|> nctId: NCT06381908 id: 1-10-72-19-24 briefTitle: The Effects of Combined Energy and Carbohydrate Restriction on Exercise Capacity acronym: CHO-EX overallStatus: RECRUITING date: 2024-04-01 date: 2024-12-15 date: 2024-12-15 date: 2024-04-24 date: 2024-04-24 name: University of Aarhus class: OTHER name: Uni... |
<|newrecord|> nctId: NCT06381895 id: SYSKY-2023-467-01 briefTitle: The Efficacy of Radiomics to Predict Tumor Microenvironment Markers and Comprehensive Therapy for Bladder Cancer overallStatus: COMPLETED date: 2023-05-30 date: 2024-02-01 date: 2024-02-20 date: 2024-04-24 date: 2024-04-24 name: Sun Yat-Sen Memorial Hos... |
<|newrecord|> nctId: NCT06381882 id: MiPac briefTitle: The Role of the Human Microbiome in Patients After Pancreatic Resection. acronym: MiPac overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-01 date: 2026-11-01 date: 2024-04-24 date: 2024-04-24 name: St. Antonius Hospital class: OTHER briefSummary: The... |
To identify the dynamics of the microbiome, as well as the possibly related short-term and long-term complications, multiple samples at different timepoints are needed from the patients. conditions: Pancreas Cancer conditions: Pancreas Neoplasm conditions: Pancreas Adenocarcinoma conditions: Periampullary Cancer condit... |
<|newrecord|> nctId: NCT06381869 id: CRNHA 2018-2 briefTitle: Bioavailability of Pea Protein in Young and Old Volunteers acronym: NUTRALYS overallStatus: COMPLETED date: 2019-01-10 date: 2019-06-13 date: 2019-06-13 date: 2024-04-24 date: 2024-04-24 name: Roquette Freres class: INDUSTRY name: CRNH Auvergne name: Univers... |
<|newrecord|> nctId: NCT06381856 id: EPM_2024-00227-01 briefTitle: Improving Participation of Autistic Children and Adolescents in the Habilitation Process acronym: IMPAC overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2025-05 date: 2025-12 date: 2024-04-24 date: 2024-04-24 name: Region Örebro County class: OTHER... |
<|newrecord|> nctId: NCT06381843 id: WSKCT004 briefTitle: A Clinical Study to Evaluate the Safety and Immunogenicity of the Recombinant COVID-19 Vaccine (Sf9 Cell) as a Booster overallStatus: COMPLETED date: 2022-08-02 date: 2023-03-29 date: 2023-12-30 date: 2024-04-24 date: 2024-04-25 name: WestVac Biopharma Co., Ltd.... |
A total of 120 participants will be enrolled, participants will be randomized 1:1 to receive a single dose of Recombinant COVID-19 vaccine (Sf9 Cell) (test group) or COVID-19 Vaccine (Vero Cell), Inactivated. conditions: COVID-19 conditions: SARS-CoV-2 Infection studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZ... |
<|newrecord|> nctId: NCT06381830 id: ASCT+CART briefTitle: Clinical Study of CAR-T Cell Therapy Following ASCT for R/R B-cell Non-Hodgkin's Lymphoma overallStatus: RECRUITING date: 2024-01-01 date: 2027-01-01 date: 2027-01-01 date: 2024-04-24 date: 2024-04-24 name: The First Affiliated Hospital of Soochow University cl... |
<|newrecord|> nctId: NCT06381817 id: 2024112 briefTitle: Haplo-cord HCT vs. Haplo-HCT for T-ALL Patients overallStatus: RECRUITING date: 2024-04-01 date: 2028-03-31 date: 2028-03-31 date: 2024-04-24 date: 2024-04-26 name: The First Affiliated Hospital of Soochow University class: OTHER name: Children's Hospital of Sooc... |
Dose co-infusion of cord blood in haploidentical hematopoietic cell transplantation (haplo-HCT) lower the rate of relapse? What medical problems do participants have when having haplo-cord HCT? Researchers will compare haplo-cord HCT to haplo-HCT to see if haplo-cord HCT works to treat T-ALL. |
Participants will be infused an unrelated cord blood unit at the same day of haploidentical graft infusion. conditions: Acute T Cell Lymphoblastic Leukemia conditions: Haploidentical Hematopoietic Stem Cell Transplantation conditions: Cord Blood studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventi... |
<|newrecord|> nctId: NCT06381804 id: 24YL9001 briefTitle: Effect of Shotblocker and Palm Stimulator overallStatus: RECRUITING date: 2024-04-19 date: 2024-05 date: 2024-05 date: 2024-04-24 date: 2024-04-24 name: Necmettin Erbakan University class: OTHER briefSummary: This study discusses the advancements in nursing, par... |
<|newrecord|> nctId: NCT06381791 id: PRO00036811 briefTitle: CBD for Pain Following Orthopedic Shoulder Surgery acronym: CBD overallStatus: RECRUITING date: 2024-05-01 date: 2026-12-30 date: 2027-12-30 date: 2024-04-24 date: 2024-04-24 name: The Methodist Hospital Research Institute class: OTHER briefSummary: The goal ... |
Researchers will compare Epidiolex to a placebo solution to see if Epidiolex lowers pain after shoulder surgery. |
Participants will: |
* track their pain and what medications they use every day in a provided pain diary. A researchers will call every seven days to check on the participant and diary. |
* Complete two short surveys. Once before surgery and once after. |
* Have bloodwork tested after surgery conditions: Shoulder Osteoarthritis conditions: Rotator Cuff Injuries studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This study is designed as a randomized, double-blinded controlled trial. Pa... |
<|newrecord|> nctId: NCT06381778 id: 112006-E briefTitle: Taiwan Registry of Hypertrophic Cardiomyopathy (THIC) Research Synopsis overallStatus: RECRUITING date: 2023-02-06 date: 2027-12-01 date: 2027-12-01 date: 2024-04-24 date: 2024-04-24 name: Far Eastern Memorial Hospital class: OTHER briefSummary: Hypertrophic car... |
<|newrecord|> nctId: NCT06381765 id: Serratus-Pectointercostal briefTitle: Serratus Plane Block and Pectointercostal Block overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-08-01 date: 2024-08-01 date: 2024-04-24 date: 2024-04-24 name: Cukurova University class: OTHER briefSummary: ASA I-II female patients ... |
<|newrecord|> nctId: NCT06381752 id: CPMvsPT briefTitle: Value of Continuous Passive Motion in Rehabilitation After Total Knee Replacement overallStatus: COMPLETED date: 2019-06-25 date: 2020-03-31 date: 2020-03-31 date: 2024-04-24 date: 2024-04-24 name: Johannes Gutenberg University Mainz class: OTHER briefSummary: Im... |
<|newrecord|> nctId: NCT06381739 id: M011 briefTitle: A Trial of a Next Generation COVID-19 Vaccine Delivered by Inhaled Aerosol acronym: AeroVax overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-07 date: 2026-07 date: 2024-04-24 date: 2024-04-25 name: McMaster University class: OTHER name: Canadian Institutes... |
To be in the study participants will have to have already had three doses of a messenger ribonucleic acid (mRNA) COVID vaccine and be generally healthy. Participants are given a single dose of the vaccine by breathing in a fine mist that goes directly into the lungs. |
During follow-up participants will: |
* visit the clinic for checkups and blood tests at 2, 4 and 8 weeks after vaccination |
* report their symptoms for 24 weeks after getting the vaccine. |
In some participants, the researchers will collect cells from the lung 4 weeks after vaccination (a test known as a bronchoscopy). conditions: COVID-19 Infection studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPA... |
<|newrecord|> nctId: NCT06381726 id: Progetto AIRC IG-2022 ID 27184 briefTitle: Personalized Rendering of Motor System Functional Plasticity Potential to Improve Glioma Resection and Quality of Life overallStatus: RECRUITING date: 2024-03-07 date: 2028-02-28 date: 2028-02-28 date: 2024-04-24 date: 2024-04-24 name: Univ... |
Hypothesis The plastic potential of motor system suggests that reorganization of circuits controlling hand movements could be presurgically fostered in LGG patients by enhancing plasticity with up-front motor-rehabilitation and/or by decreasing tumor infiltration with up-front chemotherapy. Advanced neuroimaging allows... |
Aims The project has 4 aims, investigating: A) the presurgical functional (FC) and structural (SC) connectomics of the hand-motor network to picture the spontaneous reorganization and the influence of clinical, imaging and histomolecular variables; B) the dynamic of FC and SC after tumor resection; C) changes in FC and... |
Experimental Design Resting-state fMRI and diffusion-MRI will provide FC and SC maps pre- and post-surgery; personalized up-front motor rehabilitation and/or chemotherapy will be administered; Intraoperative brain mapping procedures will generate data to validate the maps. |
Expected Results |
1. Provide a tool to render the motor functional reorganization predictive of surgical outcome. |
2. Identify demographic, clinical and imaging variables associated with functional reorganization. |
3. Describe the gain induced by up-front treatment. |
4. Distinguish "patterns" predicting chance for GTR/STR from "patterns" suggesting need for up-front treatment. |
Impact On Cancer Results will increase the achievement of GTR/STR, preserving motor integrity, with dramatic impact on LGGs natural history. conditions: Glioma conditions: Glioma, Malignant studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients... |
<|newrecord|> nctId: NCT06381713 id: ONZ-2024-0158 briefTitle: Effect and Cost-utility of of High Intensity vs. Low Intensity Speech Intervention in Children With Cleft Palate overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-12 date: 2027-12 date: 2024-04-24 date: 2024-04-24 name: University Ghent class: OTHE... |
Before this intensity can be implemented and utilized in clinical practice, the effect of this novel program on a larger societal scale must be determined. This project will compare the effect of high intensity and low intensity speech intervention in children with a cleft palate in terms of speech, quality of life, an... |
<|newrecord|> nctId: NCT06381700 id: DF CO2405/0014 (P) briefTitle: Effectiveness of MySmile App for Improving the Oral Health of Secondary School Children: overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-06 date: 2025-06 date: 2024-04-24 date: 2024-04-24 name: University of Malaya class: OTHER briefSummary:... |
1. Will the MySmile app be more effective in improving secondary school children's dental plaque and gingival health over and above the existing school dental service (SDS)? |
2. Will the MySmile app be more effective in improving secondary school children's oral health knowledge, attitudes, and behaviours over and above the existing SDS? |
3. Is the MySmile app easy to use by secondary school children? |
4. Is the MySmile app acceptable to use from the perspective of secondary school children? |
Participants in the intervention group will receive the SDS and MySmile app. The control group will receive SDS only. Therefore the researcher will compare between the intervention and control group in terms of dental plaque, gingival health, oral health knowledge, oral health attitudes and oral health behaviours. cond... |
<|newrecord|> nctId: NCT06381687 id: 2023-3118978 id: PID2022-141095NB-I00 type: OTHER_GRANT domain: Spanish Ministry of Science, Innovation and Universities briefTitle: A Movement and Music Programme in Early Childhood Education and Care (The MoviMusi Study Protocol) acronym: MOVIMUSI overallStatus: RECRUITING date: 2... |
<|newrecord|> nctId: NCT06381674 id: OHSU: 25890 id: HT9425-23-1-0845 type: OTHER_GRANT domain: Department of Defense briefTitle: Wearable Technology to Characterize and Treat mTBI Subtypes: Biofeedback-Based Precision Rehabilitation acronym: SuBTyPE overallStatus: NOT_YET_RECRUITING date: 2024-05-13 date: 2028-09-30 d... |
<|newrecord|> nctId: NCT06381661 id: APHP240385 briefTitle: Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Bayesian Basket Trial acronym: PALETTE overallStatus: NOT_YET_RECRUITING date: 2026-04-01 date: 2029-05-01 date: 2032-... |
<|newrecord|> nctId: NCT06381648 id: 23228/LyMIC briefTitle: Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC) acronym: LyMIC overallStatus: RECRUITING date: 2023-04-15 date: 2026-06-18 date: 2026-06-18 date: 2024-04-24 date: 2024-04-25 name: City of Hope Medical Center class: OTHER briefSummar... |
This study seeks to develop a liquid biopsy assay that can accurately detect LNM before treatment in ICC patients. conditions: Cholangiocarcinoma conditions: Cholangiocarcinoma, Intrahepatic conditions: Cholangiocarcinoma Resectable conditions: Cholangiocarcinoma; Liver studyType: OBSERVATIONAL observationalModel: CASE... |
<|newrecord|> nctId: NCT06381635 id: FD-BUE-REC: IRB000124920 briefTitle: Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis overallStatus: RECRUITING date: 2024-04-01 date: 2024-10-01 date: 2025-01-01 date: 2024-04-24 date: 2024-04-24 name: Ain Shams University class: OTHER briefSummary: The ... |
The main question \[s\] \] is to \[ learn about, test, compare etc.\] it aims to answer are: |
1. Is Aloe Vera Gel and Manuka Honey effective in management of Radiation Induced Mucositis? |
2. Does Aloe Vera Gel and Manuka Honey affect the level of TGFβ1 and EGF in saliva of patients with radiation induced mucositis? participants will be asked to apply Aloe Vera Gel and Manuka Honey or saline three times daily during radiotherapy and 6 months after radiotherapy. conditions: Radiation Mucositis studyType: ... |
<|newrecord|> nctId: NCT06381622 id: CTA no: 2023-510028-63-00 briefTitle: Combining Lidocaine and Ropivacaine for an Infraclavicular Brachial Plexus Nerve Block overallStatus: RECRUITING date: 2024-04-18 date: 2024-08-03 date: 2024-09-03 date: 2024-04-24 date: 2024-04-24 name: Nordsjaellands Hospital class: OTHER brie... |
<|newrecord|> nctId: NCT06381609 id: 69HCL22_0901 briefTitle: Peer Support in Alcohol Dependence acronym: PEERSIAD overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-11-01 date: 2027-11-01 date: 2024-04-24 date: 2024-04-24 name: Hospices Civils de Lyon class: OTHER briefSummary: Alcohol use disorder (AUD) af... |
However, 20-40% of patients with AUD are lost to follow-up at an early stage. Consequently, it is important for addiction departments to implement and evaluate innovative tools and interventions, including the involvement of peer support, to help patients remain in care, and to assess whether peer support has a positiv... |
Addiction peer support specialists (APSSs) are individuals who have personally experienced addiction, and who have decided to use their experience to assist other people going through a similar situation, after completing a specific official graduation. |
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