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25 subjects GROUP A: Study group: patients suffering from ankle instability |
25 subjects GROUP B: control group: healthy voluntary subjects not affected by ankle pathology conditions: Ankle Disease studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 50 type: ESTIMATED name: jumping performance measure: verify the... |
<|newrecord|> nctId: NCT06318481 id: IRB-80/2023 briefTitle: TADCLOT- a Double Blind Randomized Controlled Trial acronym: TADCLOT overallStatus: RECRUITING date: 2024-02-15 date: 2024-11-15 date: 2024-12-15 date: 2024-03-19 date: 2024-03-19 name: National Institute of Cardiovascular Diseases, Pakistan class: OTHER name... |
<|newrecord|> nctId: NCT06318468 id: N202306106 briefTitle: The Effectiveness of Various Teaching Methods to Enhance the Comprehensive Nursing Assessment Skills of New Nurses overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-10-31 date: 2024-10-31 date: 2024-03-19 date: 2024-03-19 name: Taipei Medical Universi... |
<|newrecord|> nctId: NCT06318455 id: İstanbul University-Cerrahpaşa briefTitle: The Effect of Breathing Exercise on Sleep and Stress Levels in Women With Breast Cancer Receiving Chemotherapy Treatment overallStatus: RECRUITING date: 2023-11-01 date: 2024-04-30 date: 2024-04-30 date: 2024-03-19 date: 2024-03-19 name: Un... |
<|newrecord|> nctId: NCT06318442 id: 22HH8018 briefTitle: The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes overallStatus: NOT_YET_RECRUITING date: 2024-04-06 date: 2027-06-01 date: 2027-06-01 date: 2024-03-19 date: 2024-03-19 name: Imperial College London class: OTHER briefSummary: TITLE: How GLP... |
DESIGN: A double-blind study evaluating how GLP-1 analogues, compared with metformin, prevent hyperglycaemia in response to a 7-day course of dexamethasone (DEX) 6 mg once daily. This is a mechanistic experimental medicine study. |
AIMS: To evaluate the mechanisms by which GLP-1 analogues reduce steroid-induced hyperglycaemia compared to metformin. |
OUTCOME MEASURES: |
* Primary: Glucose tolerance in response to standardised mixed meal test (MMT) lasting for 240 minutes, measured in all participants at baseline and on day 7 DEX. |
* Secondary: Indices of insulin resistance (M-value), beta-cell function (acute insulin response to glucose) and disposition, as measured by a combined IV glucose tolerance test and hyperinsulinaemic-euglycaemic clamp, performed at baseline and on day 7 DEX. |
* Exploratory: Tissue specific changes in adipose AMPK determined from adipose and muscle biopsies, taken from a subset of approximately 8 individuals in each group. |
ELIGIBILITY: People living with pre-diabetes or lifestyle controlled diabetes |
STUDY DURATION: This study will take place over 3 weeks for each partcipant. Study procedures include 10 days of baseline continuous glucose monitoring (CGM) followed by 7 days of dexamethasone with GLP-1, metformin or placebo. Participants will attend a follow-up visit 3-5 days after completing the 7-day course of stu... |
ANTICIPATED IMPACT: Mechanistic evidence for the use of GLP-1 analogues, compared with metformin, in the treatment of steroid-induced diabetes. conditions: Steroid-Induced Diabetes conditions: Steroid Induced Hyperglycemia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPu... |
<|newrecord|> nctId: NCT06318429 id: diabet briefTitle: Evaluation of the Effect of Stretching Exercises Applied to Diabetes Patients on Physiological Parameters and Compliance to Treatment: A Randomized Controlled Study overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2024-06-30 date: 2024-06-30 date: 2024-03-... |
<|newrecord|> nctId: NCT06318416 id: HSR230382 briefTitle: Precision Rifampin Trial for Personalized Dosing acronym: P-RIF overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2027-01-30 date: 2028-01-30 date: 2024-03-19 date: 2024-03-21 name: University of Virginia class: OTHER name: Haydom Lutheran Hospital name:... |
<|newrecord|> nctId: NCT06318403 id: 177012 briefTitle: Estradiol Supplementation and Rotator Cuff Repair acronym: ESTRCR overallStatus: NOT_YET_RECRUITING date: 2025-04 date: 2028-03 date: 2028-05 date: 2024-03-19 date: 2024-03-28 name: University of Utah class: OTHER briefSummary: Rotator cuff tears in the shoulder a... |
<|newrecord|> nctId: NCT06318390 id: 2023-0271 briefTitle: The Impact of KETO5 XOGenius Beverage on Markers of Physiological and Neurocognitive Health overallStatus: RECRUITING date: 2023-08-01 date: 2024-12-31 date: 2025-08-31 date: 2024-03-19 date: 2024-03-19 name: The University of Texas at Arlington class: OTHER br... |
<|newrecord|> nctId: NCT06318377 id: 2022-0541 briefTitle: Peanuts and Neurocognitive / Cardiovascular Health in Black Individuals overallStatus: RECRUITING date: 2022-09-01 date: 2024-12-31 date: 2025-08-31 date: 2024-03-19 date: 2024-03-19 name: The University of Texas at Arlington class: OTHER briefSummary: The over... |
<|newrecord|> nctId: NCT06318364 id: TJ-IRB202402016 briefTitle: Postoperative Delirium in the Post-anesthesia Care Unit overallStatus: RECRUITING date: 2024-01-20 date: 2024-12-30 date: 2024-12-30 date: 2024-03-19 date: 2024-03-19 name: Qin Zhang class: OTHER name: National Natural Science Foundation of China briefSum... |
<|newrecord|> nctId: NCT06318351 id: TJ-IRB202402015 briefTitle: Transcutaneous Acupoint Electrical Stimulation and Postoperative Delirium Delirium overallStatus: RECRUITING date: 2024-02-01 date: 2024-12-30 date: 2025-08-30 date: 2024-03-19 date: 2024-04-09 name: Qin Zhang class: OTHER name: National Natural Science F... |
<|newrecord|> nctId: NCT06318338 id: UPCC 14523 id: 854756 type: OTHER domain: Penn IRB briefTitle: Virtual Reality to Promote Relaxation Prior to Simulation overallStatus: RECRUITING date: 2024-03 date: 2025-03 date: 2025-03 date: 2024-03-19 date: 2024-03-19 name: Abramson Cancer Center at Penn Medicine class: OTHER b... |
<|newrecord|> nctId: NCT06318325 id: ADINEGEV-2021_102 briefTitle: Growth Process and Development of the Musculoskeletal System in Young Gymnasts overallStatus: RECRUITING date: 2024-01-01 date: 2026-03-15 date: 2026-03-15 date: 2024-03-19 date: 2024-04-16 name: University of Haifa class: OTHER name: The Academic colle... |
<|newrecord|> nctId: NCT06318312 id: HYP_MR_2024 briefTitle: Effects of Hypoxia on Cognitive Performance acronym: HYPCOG overallStatus: NOT_YET_RECRUITING date: 2024-03-27 date: 2024-04-12 date: 2024-05-03 date: 2024-03-19 date: 2024-03-19 name: University of Castilla-La Mancha class: OTHER briefSummary: The goal of th... |
* What is the best hypoxia exposure to improve reaction time, anticipation, attention and memory tasks? |
* Which hypoxia exposure causes the greatest detriments in cognitive function? conditions: Hypoxia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 30 ... |
<|newrecord|> nctId: NCT06318299 id: 109227 briefTitle: Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal Fluid acronym: KetoBrain overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-12 date: 2024-12 date: 2024-03-19 date: 2024-03-21 name: University of ... |
Ketone bodies can be administered exogenously, and the most commonly used in clinical trials is 3-hydroxybutyrate (3-OHB). 3-OHB is carried by simple diffusion and facilitated diffusion through several monocarboxylic acid transporters (MCTs) across the blood-brain barrier. |
To our knowledge, no studies in human adults exist that concurrently measure 3-OHB concentrations in blood and cerebrospinal fluid (CSF) after ingestion or infusion of exogenous ketone supplementation, necessitating further study. |
Aims: |
* The 3-OHB CSF/blood ratio after oral ingestion of 30 g ketone ester - primary endpoint |
* The window of effect: Ketone supplementation 1 h or 2 h before CSF sampling |
* If concentration measurements by point-of-care testing are non-inferior to mass spectrometry |
* If acute 3-OHB ingestion increases plasma brain-derived neurotrophic factor (BDNF) levels conditions: Ketosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 24 type: ESTIMATED name: Ketone Ester name: ... |
<|newrecord|> nctId: NCT06318286 id: MK3475-IIT-60977 briefTitle: Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma acronym: PENINSULA overallStatus: NOT_YET_RECRUITING date: 2024-03-13 date: 2026-04-30 date: 2026-10-30 date: 2024-03-19 date: 2024-03-19 name: Hyogo Medical Univ... |
<|newrecord|> nctId: NCT06318273 id: M24-742 briefTitle: A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic Castration-Resistant Prostate Cancer overallStatus: RECRUITING date: 2024-03-08 date: 2027-06-16 date: 2027-06-17 date: 20... |
ABBV-969 is an investigational drug being developed for the treatment of metastatic castration-resistant prostate cancer (mCRPC). There are parts to this study. Participants will receive ABBV-969 as a single agent at different doses. Approximately 120 adult participants will be enrolled in the study across sites worldw... |
In part 1 (dose escalation), ABBV-969 will be intravenously infused in escalating doses as a monotherapy. In part 2, multiple doses will be selected from Part 1 and mCRPC participants will be assigned to one of these doses in a randomized fashion to determine the recommended Phase 2 dose. The estimated duration of the ... |
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, and scans. conditions: Metastatic Castration-Resistant Prostate Cancer study... |
<|newrecord|> nctId: NCT06318260 id: 2023-508298-10-00 briefTitle: Haemodynamic Effects of Dobutamine in Patients With Wild-type Transthyretin Amyloid Cardiomyopathy (ATTRwt) acronym: DobATTR overallStatus: RECRUITING date: 2024-04-08 date: 2025-09 date: 2026-03 date: 2024-03-19 date: 2024-04-17 name: Steen Hvitfeldt P... |
* What are the effects of increasing dosages of dobutamine infusion on cardiac output and filling pressures in patients with symptomatic ATTRwt. |
* Safety of dobutamine infusion in this patient population. |
Participants will be given increasing dosages of dobutamine infusion, and its effect on cardiac output and filling pressures will be assessed non-invasively by echocardiography, and invasively by right heart catheterization, simultaneously. conditions: ATTR Amyloidosis Wild Type studyType: INTERVENTIONAL phases: PHASE1... |
<|newrecord|> nctId: NCT06318247 id: 2022-134(R) briefTitle: Using Xenograft Combined With Barrier Membrane to Improve the Formation of Deep Periodontal Pockets overallStatus: RECRUITING date: 2023-06-01 date: 2024-12-30 date: 2025-12-30 date: 2024-03-19 date: 2024-03-19 name: The Dental Hospital of Zhejiang University... |
<|newrecord|> nctId: NCT06318234 id: 202435 briefTitle: PET/MR Evaluation of Regression Grading After Neoadjuvant Therapy for Rectal Cancer overallStatus: RECRUITING date: 2024-01-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-19 date: 2024-03-19 name: Xiao Chen class: OTHER briefSummary: This project aims to evalu... |
<|newrecord|> nctId: NCT06318221 id: 06156930 briefTitle: Effects of Perioperative Immunonutrition in Patients With Head and Neck Cancer overallStatus: COMPLETED date: 2019-05-01 date: 2021-02-01 date: 2021-02-01 date: 2024-03-19 date: 2024-03-19 name: TC Erciyes University class: OTHER briefSummary: A prospective rand... |
Five days before surgery and the postoperative day 10, immunonutrition support was given to the intervention group (n=17), and standard EN support was given to the control group (n=17). Body analyses were made, food consumption records were taken, NRS-2002 and quality of life scales were applied, and biochemical parame... |
<|newrecord|> nctId: NCT06318208 id: C-LCI briefTitle: Pulmonary Function in Non-hospitalized Adults and Children After Mild COVID-19 overallStatus: COMPLETED date: 2021-04-20 date: 2022-01-03 date: 2022-01-03 date: 2024-03-19 date: 2024-03-26 name: University of Rostock class: OTHER briefSummary: The study investigate... |
Therefore, 110 patients, aged 6-60 years, were recruited by telephone 4-12 weeks after laboratory-confirmed positive PCR and invited for a lung function testing. Every patient with abnormalities in pulmonary function was invited to a follow-up 3 months after the first appointment to assess changes in lung function valu... |
Patients with a pre-existing lung disease and smokers within the last five years were excluded beforehand. |
Additionally to lung function testing we did a throat swab at each appointment to analyse via Multiplex PCR whether the patients had any other respiratory infection at the time of the pulmonary function testing. conditions: SARS-CoV-2 Infection studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPE... |
<|newrecord|> nctId: NCT06318195 id: 2023-06821-01 briefTitle: Condensed Digital Prolonged Exposure for Individuals Treated Within Somatic Trauma Care. acronym: CiPE overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-02 date: 2026-08 date: 2024-03-19 date: 2024-03-19 name: Karolinska Institutet class: OTHER nam... |
<|newrecord|> nctId: NCT06318182 id: NCT-SBF-EK-001 briefTitle: Testicular Self-Examination Awareness in Young Men overallStatus: ACTIVE_NOT_RECRUITING date: 2022-12-09 date: 2023-11-20 date: 2024-07-15 date: 2024-03-19 date: 2024-03-19 name: Hitit University class: OTHER name: Ondokuz Mayıs University briefSummary: Th... |
H0 Hypothesis: Education based on the health belief model has no effect on the awareness of testicular self-examination and health beliefs about testicular self-examination of young men in the experimental and control groups. |
H1a Hypothesis: The training based on the health belief model will increase the awareness of young men in the experimental group about testicular self-examination compared to those in the control group. |
H1b Hypothesis: The training based on the health belief model will increase the mean scores of the sensitivity subscale of young men in the experimental group compared to those in the control group. |
H1c Hypothesis: The training based on the health belief model will increase the mean scores of the benefit subscale of young men in the experimental group compared to those in the control group. |
H1d Hypothesis: The training based on the health belief model will increase the mean scores of the seriousness subscale of young men in the experimental group compared to those in the control group. |
H1e Hypothesis: The training based on the health belief model will decrease the mean scores of the barriers subscale of young men in the experimental group compared to those in the control group. |
H1f Hypothesis: The training based on the health belief model will increase the mean scores of the health motivation subscale of young men in the experimental group compared to those in the control group. |
H1g Hypothesis: The training based on the health belief model will increase the mean scores of the self-efficacy subscale of young men in the experimental group compared to those in the control group. conditions: Testicular Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL p... |
<|newrecord|> nctId: NCT06318169 id: BIO89-100-131 briefTitle: A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis) overallStatus: RECRUITING date: 2024-03-13 date: 2026-12 date: 2029-02 date: 2024-03-19 date: 2024-04-29 name: 89bio, Inc. class: INDUSTRY... |
<|newrecord|> nctId: NCT06318156 id: ZSLL-KY-2024-056-03 briefTitle: Exploring the Distribution Patterns and Infrared Characteristics of Force-sensitive Acupoints in Different Lumbar Nerve Segments in Patients With LDH Based on "Press Quickly" Theory overallStatus: RECRUITING date: 2022-01-01 date: 2025-01-01 date: 202... |
<|newrecord|> nctId: NCT06318143 id: U01HL168084 type: NIH link: https://reporter.nih.gov/quickSearch/U01HL168084 briefTitle: mAnaging siCkle CELl disEase Through incReased AdopTion of hydroxyurEa in Nigeria acronym: ACCELERATE overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2027-08 date: 2028-03 date: 2024-03-19... |
<|newrecord|> nctId: NCT06318130 id: LEAD-LBP briefTitle: Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes acronym: LEAD-LBP overallStatus: RECRUITING date: 2023-01-01 date: 2024-12-31 date: 2025-06-30 date: 2024-03-19 date: 2024-04-05 name: National University Hospital, Singapore class: OTHER bri... |
Group 1: Fixed helix, lumenless pacing lead (FHL) Group 2: Extendable helix, stylet driven pacing lead (EHL) primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Subjects will be blinded to the type of pacing lead received. Operators will not be blinded as they will be performing the procedure. Post-procedure,... |
<|newrecord|> nctId: NCT06318117 id: 3398-1 briefTitle: Reason for Prescribing Rice Infant Formula overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2025-09-30 date: 2025-12-31 date: 2024-03-19 date: 2024-03-25 name: Mead Johnson Nutrition class: INDUSTRY name: BioFortis briefSummary: The main purpose of this st... |
<|newrecord|> nctId: NCT06318104 id: DI/24/310/03/4 briefTitle: Efficacy and Safety of a Triple Eradication Scheme for Helicobacter Pylori Based on Tegoprazan vs Esomeprazole overallStatus: NOT_YET_RECRUITING date: 2024-04-19 date: 2024-11-29 date: 2025-02-28 date: 2024-03-19 date: 2024-03-19 name: Hospital General de ... |
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