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The investigators hypothesize that plasma Willebrand factor (VW) activity and the intensity of endothelial activation are different depending on the Bothrops snake species involved in the bites in Guyana and Martinique. Due to the specific properties of the venoms of each Bothrops species, the activity of the Willebran... |
The investigators will demonstrate that the accumulation of Willebrand factor (VW) and the increase in its activity are responsible for the endothelial activation and micro-thrombosis observed during envenomations by Bothrops lanceolatus bites, whereas the decrease in its activity induced by the venoms of endemic Bothr... |
This study will highlight the importance of changes in Willebrand factor activity on endothelial activation and the initiation of micro-thrombosis in the case of Bothrops lanceolatus envenomations and on primary haemostasis and bleeding disorders in the case of endemic Bothrops in Guyana. This new knowledge is importan... |
<|newrecord|> nctId: NCT06304701 id: PI-2023-08 briefTitle: Handwritten Text Production in Adults With Autism acronym: PEMTAA overallStatus: RECRUITING date: 2023-11-29 date: 2025-05 date: 2025-05 date: 2024-03-12 date: 2024-03-12 name: Centre Hospitalier de Niort class: OTHER name: University of Poitiers briefSummary:... |
The secondary objectives are: |
* Identifying links between specific deficits of ASD and difficulties in written production. |
* Identifying links between the severity of ASD and difficulties in written production. |
The primary evaluation criterion is the quantity of written production, namely the number of words produced in 5 minutes on a text copying task (BHK) and in 15 minutes on each of the two written production tasks (descriptive and persuasive). |
The secondary evaluation criteria are: |
* Graphomotor indicators of written production (writing speed, pre-writing time, pause time, writing time, handwriting size, results obtained in BHK (number of words produced, letter height, line parallelism, telescoping, ambiguous letters). |
* Cognitive and psycholinguistic indicators of written production (presence of titles, presence of paragraphs, number of sentences, number of words per sentence, lexical richness, lexical field, number of action verbs, morphological complexity, number of syntactic markers related to oneself, number of syntactic markers... |
* Results obtained in tests (writing habits questionnaire, Autism Diagnostic Observation Scale (second edition), Wechsler Adult Intelligence Scale (fourth edition) - Similarities subtest, Wechsler Adult Intelligence Scale (fourth edition) - Vocabulary subtest, Rey Figure, MASC). conditions: Autism Spectrum Disorder stu... |
<|newrecord|> nctId: NCT06304688 id: University of Jaén_24 briefTitle: Yoga and Diet on Cognitive, Nutritional Status, Mental and Functional Abilities in Older Adults overallStatus: COMPLETED date: 2023-11-13 date: 2024-02-05 date: 2024-02-12 date: 2024-03-12 date: 2024-04-04 name: University of Jaén class: OTHER brief... |
<|newrecord|> nctId: NCT06304675 id: 905055423985 briefTitle: Manageable Environmental Factors in Migraine overallStatus: COMPLETED date: 2023-09-30 date: 2024-02-15 date: 2024-03-04 date: 2024-03-12 date: 2024-03-12 name: Samsun University class: OTHER briefSummary: There is limited and insufficient information on the... |
<|newrecord|> nctId: NCT06304662 id: *University of Jaén briefTitle: Yoga for Physical and Mental Health overallStatus: COMPLETED date: 2023-11-13 date: 2024-02-09 date: 2024-02-19 date: 2024-03-12 date: 2024-03-26 name: University of Jaén class: OTHER briefSummary: In the university environment, where academic pressur... |
<|newrecord|> nctId: NCT06304649 id: Cast21CHLA2023Study1SAP briefTitle: Clinical Evaluation of Cast21 Short Arm Product During Treatment of Distal Radial or Distal Ulnar Fractures acronym: Cast21 SAP overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-10 date: 2024-12 date: 2024-03-12 date: 2024-03-12 name: Cas... |
A secondary objective will be to characterize the clinician and patient experience with the Cast21 Short Arm Product. conditions: Fractures, Closed conditions: Fractures Bone conditions: Fracture conditions: Fractures conditions: Radius; Fracture, Lower or Distal End conditions: Ulna Fractures conditions: Radius Distal... |
<|newrecord|> nctId: NCT06304636 id: DC15-MM-01 briefTitle: Descartes-15 for Patients With Relapsed/Refractory Multiple Myeloma acronym: DC15-MM-01 overallStatus: RECRUITING date: 2024-03-01 date: 2026-12-01 date: 2027-10-01 date: 2024-03-12 date: 2024-03-12 name: Cartesian Therapeutics class: INDUSTRY briefSummary: Th... |
<|newrecord|> nctId: NCT06304623 id: CIRE.112 briefTitle: SVF for Treating Pulmonary Fibrosis Post COVID-19 acronym: SVFCOVID-19 overallStatus: COMPLETED date: 2020-05-05 date: 2024-03-01 date: 2024-03-01 date: 2024-03-12 date: 2024-03-12 name: Michael H Carstens class: OTHER name: Ministerio de Salud de Nicaragua name... |
This is a prospective, multicenter, expanded access interventional study of subjects recovered from COVID-19 pneumonia to assess their response to intravenous administration of adipose-derived autologous SVF. |
Primary objective |
The purpose of this study was to evaluate the safety of single intravenous injections of autologous adipose-derived SVF produced using the GID SVF-2 device system for the treatment of secondary respiratory distress associated with COVID-19. |
Secondary objective |
To evaluate the efficacy of the initial treatment with SVF IV. conditions: Pulmonary Fibrosis studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 40 type: ACTUAL name: Autologous adipose-derived SVF IV administration measure: Safety of t... |
<|newrecord|> nctId: NCT06304610 id: ONZ-2024-0044 briefTitle: Hospital-based Validation of the New ELEVATE Screening Tool in Belgium and Ecuador acronym: ELEVATE-Pilot overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-12 date: 2024-03-28 name: University Hospital, Ghent... |
In this final stage of the project, a hospital-based validation study is deployed in Belgium and Ecuador to clinically validate the new ELEVATE screening test based on self-samples and endocervical samples. The simultaneous detection of HPV DNA and the proteomic markers allows for the detection of those cervical HPV in... |
At each study site, 100 women between 30-65 years old, with a recent abnormal pap smear result will be recruited in the colposcopy waiting room. After registration and signing the informed consent form, each woman will be asked to fill out a short self-administered questionnaire for socio-demographic information. Each ... |
Besides analyzing all samples on the new ELEVATE screening test, the following standard tests will also be performed on all samples (at Ghent University - including the shipped samples of Ecuador): |
* AnyplexTM II HPV HR Detection (Segeene Inc., Korea): approved comparison test |
* ELISA protein detection: only available comparison test |
In order to generate HPV DNA results locally, that can be communicated to the participants in short time (versus waiting for AnyplexTM II HPV HR Detection test results after shipment to Belgium), in Ecuador the following additional standard test will be performed on the100 endocervical samples (before shipment to Belgi... |
• HPV DNA Mole Bioscience test |
Concordance between the test results of the ELEVATE screening test and standard lab tests on both type of samples will be defined, for HPV DNA as well as protein detection. Additionally, the sensitivity and specificity of the HPV DNA test and the protein test of the ELEVATE screening test will be defined, according to ... |
<|newrecord|> nctId: NCT06304597 id: 17651 briefTitle: Evaluating PD-1/PD-L1 in Locally Advanced Rectal Cancer by Quantitative Fluorescence Molecular Endoscopy acronym: PREDICT overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03-01 date: 2025-06-01 date: 2024-03-12 date: 2024-03-12 name: University Medical... |
<|newrecord|> nctId: NCT06304584 id: P-2023-143 briefTitle: Cross-sectoral Rehabilitation of Older High-risk Patients With Hip Fracture overallStatus: RECRUITING date: 2023-05-15 date: 2024-09-15 date: 2025-05-15 date: 2024-03-12 date: 2024-03-12 name: University Hospital Bispebjerg and Frederiksberg class: OTHER name:... |
The main questions aim to answer: |
* how patients are doing up to one year after hip fracture surgery on different outcomes across the continuum of rehabilitation being offered |
* what expectations, experiences and satisfaction patients have for the overall rehabilitation process after a hip fracture |
Participants age 65 and above with home address in Frederiksberg municipality, living in own home, admitted and treated for at hip fracture at Department of Orthopedic Surgery, Bispebjerg Hospital, will be asked for participation. conditions: Hip Fractures conditions: Rehabilitation conditions: Recovery of Function stu... |
<|newrecord|> nctId: NCT06304571 id: HC006-001 briefTitle: A Study of HC006 in Subjects With Advanced Solid Tumors overallStatus: RECRUITING date: 2024-02-27 date: 2026-03-15 date: 2026-07-16 date: 2024-03-12 date: 2024-03-12 name: HC Biopharma Inc. class: INDUSTRY briefSummary: The purpose of this study is to characte... |
<|newrecord|> nctId: NCT06304558 id: CI 240228, 2024-480 briefTitle: "Effectiveness of Non-invasive Neuromodulation Treatment for Improving Sexual Satisfaction in Healthy Subjects. overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2024-04 date: 2024-06 date: 2024-03-12 date: 2024-03-12 name: Universidad Europea ... |
As secondary objectives, the effectiveness of the XSignal device during a defined treatment period will be analyzed in terms of quality of life, pain, stress, anxiety, sexual function, sleep quality, cortisol, heart rate, blood pressure, respiratory rate, and body temperature of the same subjects, compared with a place... |
<|newrecord|> nctId: NCT06304545 id: SHR-1210-HLJ-081 briefTitle: Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With Camrelizumab overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2026-08-16 date: 2027-03-15 date: 2024-03-12 date: 2024-03-12 name: Harbin Medical University class... |
<|newrecord|> nctId: NCT06304532 id: HU123 briefTitle: Clinical Efficacy and Safety Assessment of Alsareen Capsule for the Management of H. Pylori Infection overallStatus: COMPLETED date: 2023-08-15 date: 2024-03-05 date: 2024-03-06 date: 2024-03-12 date: 2024-03-13 name: Hamdard University class: OTHER briefSummary: H... |
In conventional system of medicine H. pylori infection is treated by triple regimen antibiotic therapy that are amoxicillin, clarithromycin and metronidazole along with acid reducing proton pump inhibitor. Due to recurrence of infection this therapy is repeated multiple times resulting in drug resistance and long term ... |
<|newrecord|> nctId: NCT06304519 id: 1986626-1 briefTitle: Identifying the Optimal Dynamic Ankle-Foot Orthosis Bending Stiffness for Individuals Post-Stroke overallStatus: RECRUITING date: 2023-03-01 date: 2026-02-28 date: 2026-02-28 date: 2024-03-12 date: 2024-03-12 name: University of Delaware class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06304506 id: 514-0894/23-3000 briefTitle: Effect of Obesity on Extracellular Matrix Composition acronym: EOBECM overallStatus: RECRUITING date: 2024-03-15 date: 2024-11-15 date: 2024-12-30 date: 2024-03-12 date: 2024-03-12 name: University of Copenhagen class: OTHER briefSummary: The experiment ... |
The main questions to answer, |
- is there differences in the adipose tissue extracellular matrix in obese compared to young men is there differences in the adipose tissue extracellular matrix in old compared to young men conditions: Adipose Tissue studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventio... |
<|newrecord|> nctId: NCT06304493 id: 23-2470 briefTitle: REMINDers for Incentive Spirometry in PACU (REMIND-IS in PACU) overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-05 date: 2024-05 date: 2024-03-12 date: 2024-03-12 name: University of Colorado, Denver class: OTHER briefSummary: The purpose of this study ... |
<|newrecord|> nctId: NCT06304480 id: AFCRO-179 briefTitle: Effect of The Substitution of Animal Protein by Soya-Based Fermented Product on Human Gut Microbiome overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-07-31 date: 2024-07-31 date: 2024-03-12 date: 2024-03-12 name: University College Cork class: OTHE... |
As well as impact of meat production on the climate, it is well established that eating a diet rich in red meat promotes the growth of gut microbiome members that drive or exacerbate inflammation. Plant protein does not have these associations, and in fact it is often accompanied by fibre ingestion, which favours growt... |
<|newrecord|> nctId: NCT06304467 id: IRB#23-001133 briefTitle: CM for Patients With ALD After Liver Transplant overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-09-01 date: 2026-03-01 date: 2024-03-12 date: 2024-03-12 name: Arpan A. Patel, MD class: OTHER briefSummary: Alcohol associated liver disease (ALD)... |
The proposed study is a pilot randomized controlled trial of 30 patients with ALD who received a liver transplant; 15 will be randomized to receive a 10-week CM intervention while 15 will receive treatment as usual (TAU or control). Subjects will be asked to complete 12 study visits (including Screening and Baseline Vi... |
<|newrecord|> nctId: NCT06304454 id: P5_BG briefTitle: Board Games at Kindergarten (5 Years Old) to Improve Cognitive and Emotional Processes overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-15 date: 2024-02-29 date: 2024-03-15 date: 2024-03-12 date: 2024-03-12 name: Brain In Game scientific-technical service class: ... |
The main aim of the present study is to test the efficacy of a cognitive and emotional training program in the classroom based on board games in kindergarten students (5 years old). For this, there will be an experimental group that will carry out the cognitive and emotional game program in the classroom implemented by... |
<|newrecord|> nctId: NCT06304441 id: IPVO briefTitle: Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer overallStatus... |
<|newrecord|> nctId: NCT06304428 id: Pro00114580 briefTitle: Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications acronym: PRISM overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2028-07-01 date: 2028-07-01 date: 2024-03-12 date: 2024-03-12 name: Duke University class: OTHER name: Pa... |
The primary outcome is injurious falls, with secondary outcomes measuring how the process of care is changed and capturing patient-reported outcomes valued by stakeholders. |
The main questions this study aims to answer are: |
* Which of the three models is more effective in preventing falls with fractures? |
* What are the differences in patient-centered outcomes amongst the three models? These include pain, depression, anxiety, sleep, medication side effect burden, and fear of falling. |
* What are the differences in osteoporosis treatment and medication burden? |
The three care models are: a Deprescribing Care Model designed to reduce or stop fall-related medications, a Bone Heath Service Model designed to provide osteoporosis evaluation and management, and an Injury Prevention Service Model offering both services. |
42 SNFs will participate in this study. The three models will be incorporated into the routine care of patients at these facilities who are receiving rehabilitation after a hospitalization for a fracture. All care models will be delivered remotely to patients in the SNF and after they transition home by a post-fracture... |
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