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Establish a specialized cohort for sarcopenia through a longitudinal investigation, implementing the digital drug and digital rehabilitation interventions. |
Participants will: |
Engage in screening and assessment based on inclusion and exclusion criteria. |
Be monitored longitudinally, with tailored interventions for those with muscle atrophy and regular follow-ups for at-risk individuals. |
Key outcomes will focus on sarcopenia indicators, serum biomarkers, and clinical endpoints such as fracture rates, weakness classification, and quality of life. conditions: Sarcopenia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 10000 type: ESTIMATED measure: Appendicular skel... |
<|newrecord|> nctId: NCT06380764 id: RC.11.3.2024 briefTitle: Greater Occipital Nerve Block Value in Management of Postdural Puncture Headache overallStatus: COMPLETED date: 2023-03-02 date: 2023-07-25 date: 2023-12-01 date: 2024-04-24 date: 2024-04-24 name: Benha University class: OTHER briefSummary: Neuraxial techniq... |
Greater Occipital Nerve (GON) originates from C2-3 segments and through its muscular relations it is divided as proximal and distal parts; the most proximal part lies between obliquus capitis inferior and semispinalis and then passes through the semispinalis to pierce the trapezius muscle. In distal region of trapezius... |
<|newrecord|> nctId: NCT06380751 id: D9722C00001 briefTitle: Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer acronym: EvoPAR-BR01 overallStatu... |
<|newrecord|> nctId: NCT06380738 id: D0817R00074 id: D0817R00074 type: OTHER domain: AstraZeneca briefTitle: Real-World Clinical Experience of Patients With Metastatic Castration-Resistant Prostate Cancer Treated With Olaparib + Abiraterone (PROceed) acronym: PROceed overallStatus: RECRUITING date: 2024-02-14 date: 202... |
<|newrecord|> nctId: NCT06380725 id: jshim8zay6vd briefTitle: The Treatment of High Intensity Transcranial Current Stimulation for Alzheimer's Disease overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-08 date: 2024-12 date: 2024-04-24 date: 2024-04-24 name: Anhui Provincial Hospital class: OTHER_GOV briefSumma... |
<|newrecord|> nctId: NCT06380712 id: 6509 briefTitle: HYPERTESSA "HyperTessa User Experience Study (HTUX)" overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2024-09-30 date: 2024-10-31 date: 2024-04-24 date: 2024-04-24 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: B... |
<|newrecord|> nctId: NCT06380699 id: HJG-CZQH-QHRD106-I briefTitle: Study to Assess PK, Safety and Tolerability in Healthy Subjects overallStatus: COMPLETED date: 2023-03-16 date: 2023-11-16 date: 2023-12-25 date: 2024-04-24 date: 2024-04-26 name: Changzhou Qianhong Bio-pharma Co., Ltd. class: INDUSTRY briefSummary: Th... |
<|newrecord|> nctId: NCT06380686 id: AIO-KHT-0322/ass briefTitle: Head and Neck Carcinoma Clinical Research Platform for Molecular and Blood-based Biomarkers, Treatment and Outcome acronym: HEAT overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2029-05 date: 2030-05 date: 2024-04-24 date: 2024-04-24 name: AIO-Studi... |
<|newrecord|> nctId: NCT06380673 id: s68299 briefTitle: Stepwise Heat-Denaturated Protein Introduction for Tolerance Induction in Food Allergy acronym: TEHITI overallStatus: RECRUITING date: 2024-04-22 date: 2028-12-30 date: 2029-12-30 date: 2024-04-24 date: 2024-04-24 name: Universitaire Ziekenhuizen KU Leuven class: ... |
<|newrecord|> nctId: NCT06380660 id: ACE-106-001 briefTitle: Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors overallStatus: RECRUITING date: 2024-03-22 date: 2028-12-21 date: 2029-03-21 date: 2024-04-24 date: 2024-04-24 name: Acerand Therapeutics (Shanghai) Limited class: INDUSTRY briefSummary: The p... |
<|newrecord|> nctId: NCT06380647 id: 0004 briefTitle: Comparison of Prophylactic Acyclovir and Placebo in Prevention of Eczema Herpeticum in Pediatric Burns acronym: childburn overallStatus: COMPLETED date: 2019-10-01 date: 2020-09-30 date: 2020-09-30 date: 2024-04-24 date: 2024-04-24 name: King Edward Medical Universi... |
Objective: Compare efficacy of the prophylactic acyclovir and placebo in preventing eczema Herpeticum in paediatric burn patients conditions: Herpes Virus Infection studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Sample size of 64 patients (32 patien... |
<|newrecord|> nctId: NCT06380634 id: NYalcinbas briefTitle: The Effectiveness of Motivational Interviewing in Reducing the Use of Household Chemicals and Personal Care Products During Pregnancy overallStatus: COMPLETED date: 2023-01-23 date: 2023-12-31 date: 2024-02-20 date: 2024-04-24 date: 2024-04-24 name: Istanbul U... |
<|newrecord|> nctId: NCT06380621 id: IRC/1386/018 briefTitle: Bilateral vs Unilateral Totally Extraperitoneal Repair Among Patients With Unilateral Inguinal Hernia overallStatus: COMPLETED date: 2018-03-15 date: 2019-02-15 date: 2019-03-15 date: 2024-04-24 date: 2024-04-24 name: B.P. Koirala Institute of Health Science... |
The main questions it aims to answer are: |
* To compare complications, recurrence rates, postoperative pain, and operative duration between both groups. |
* Incidence of occult contralateral hernia Patients attending the OPD for unilateral inguinal hernia were counseled about the trial and fully encouraged to understand the difference between two procedures for unilateral hernia: bilateral exploration and bilateral TEP repair, upon which if a contralateral occult inguina... |
Researchers will compare Group A( bilateral TEP) with Group B (unilateral TEP) to see if complications, recurrence rates, postoperative pain, and operative duration occur in each group conditions: Inguinal Hernia studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose:... |
<|newrecord|> nctId: NCT06380608 id: 0047-23-ASF briefTitle: Levels of Fear, Anxiety and Wound Healing Among Aental Surgery Patients Under Local Versus General Anesthesia overallStatus: RECRUITING date: 2023-09-01 date: 2024-09-30 date: 2024-12-31 date: 2024-04-24 date: 2024-04-24 name: Zoya Haitov Ben Zikri class: OTH... |
A stress response stimulates the secretion of cortisol hormone. Cortisol levels were found to be significantly higher before dental surgery, while after the operation the hormone level dropped significantly. |
The aim of the study is to assess the level of anxiety/fear and monitor the wound healing process among patients who are about to undergo surgery to remove wisdom teeth or no more than 3 jaw implants under local anesthesia in the dental clinic compared to patients who are about to undergo the same surgery under general... |
<|newrecord|> nctId: NCT06380595 id: 23 -1533 briefTitle: Complex EVAR in Inflammatory and Infective Abdominal and Thoracoabdominal Aortic Aneurysms acronym: CEVARII overallStatus: ENROLLING_BY_INVITATION date: 2024-02-21 date: 2025-03 date: 2026-03 date: 2024-04-24 date: 2024-04-24 name: CEVARII class: OTHER name: Uni... |
<|newrecord|> nctId: NCT06380582 id: NL85595.068.23 briefTitle: Indoor Air Quality, Temperature and Cognitive Performance acronym: AEOLUS overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-12-21 date: 2024-12-21 date: 2024-04-24 date: 2024-04-24 name: Maastricht University Medical Center class: OTHER briefSu... |
Study population: The population consists of healthy young and middle-aged adults of both sexes between 18 and 40 years. |
Intervention (if applicable): Each participant undergoes 4 conditions in randomized order. Two conditions consist of poor air quality defined as 3,000 ppm carbon dioxide and 23°C or 35°C temperature, respectively. conditions: Indoor Air Quality, Temperature and Cognitive Performance studyType: INTERVENTIONAL phases: NA... |
<|newrecord|> nctId: NCT06380569 id: E-1139-21 Community Setting briefTitle: A Strength-Based Intervention to Improve Job Interview Skills in Young Adults in a Community Setting overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-01 date: 2025-12-01 date: 2024-04-24 date: 2024-04-24 name: Kessler Foundatio... |
<|newrecord|> nctId: NCT06380556 id: 25.05.2022/68 briefTitle: The Effect of Mechanical Vibration and ShotBlocker on Pain Levels During Heel Lance in Healthy Term Neonates overallStatus: COMPLETED date: 2022-11-10 date: 2023-01-30 date: 2023-07-13 date: 2024-04-24 date: 2024-04-24 name: Istanbul Medeniyet University cl... |
Within the scope of the research, parents knew which group the baby was in. However, due to the nature of the sample group, the babies were blind. |
To avoid statistical bias, study groups were coded as A, B and C; statistical blinding was performed (statistician blinding). whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 108 type: ACTUAL name: ShotBlocker name: Mechanical vibration measure: Procedural pain score- Neonatal Infant Pain Scale (NIPS) measure... |
<|newrecord|> nctId: NCT06380543 id: BILINCE briefTitle: ERCP Biliary Cannulation Success Using ESGE Algorithm acronym: BILINCE overallStatus: RECRUITING date: 2019-12-12 date: 2024-10-31 date: 2024-12-31 date: 2024-04-24 date: 2024-04-24 name: IRCCS San Raffaele class: OTHER name: Societa Italiana di Endoscopia Digest... |
The investigators hypothesised that the ESGE algorithm predicts an increased cannulation success. Nevertheless, it's unclear if this benefit is also associated with a decreased risk of complications, mainly post-procedural pancreatitis. conditions: Biliary Tract Diseases studyType: OBSERVATIONAL observationalModel: COH... |
<|newrecord|> nctId: NCT06380530 id: SIMULA briefTitle: Advanced Surgical Simulation Processes in the Correction of Skeletal Defects and Deformities acronym: SIMULA overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-05 date: 2029-05 date: 2024-04-24 date: 2024-04-24 name: Istituto Ortopedico Rizzoli class: OTHE... |
One area witnessing notable advancement is the treatment of musculoskeletal disorders (MMS) in children, adolescents, and young adults. These disorders involve severe and rare abnormalities in skeletal formation and development across three-dimensional planes, often affecting multiple limbs. Managing such deformities i... |
The application of 3D modeling and printing technologies offers a deeper understanding of deformities and facilitates improved prediction, precision, reproducibility, and safety in surgical interventions. |
The Musculoskeletal Apparatus Network (RAMS Network) centers are equipped with advanced 3D laboratories for surgical simulation and planning, aligned with the overarching goal of improving surgery quality through "in-silico" medicine (ISM) principles. |
At present, numerous complex surgeries involving Virtual Surgical Planning (VSP) and sterilizable 3D-printed Patient-Specific Instruments (PSI) and/or Graft-Specific Instruments (GSI) are being simulated and performed at the Rizzoli Institute. Preliminary data from previous protocols indicate a significant reduction in... |
The aim of this study is to enhance the current process of simulating, planning, and designing surgical support tools within 3D Printing Point-of-Care (3D POC) facilities. To achieve this, it is imperative to expand case volumes and systematically organize, categorize, and standardize simulation and planning procedures... |
<|newrecord|> nctId: NCT06380517 id: ATS23 id: 2UG1EY011751 type: NIH link: https://reporter.nih.gov/quickSearch/2UG1EY011751 briefTitle: Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age acronym: ATS23 overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-12-01 date: 2027-05-01 date: 2024-04-24... |
<|newrecord|> nctId: NCT06380504 id: RSWITCH-Ethiopia briefTitle: Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia acronym: R-SWITCH overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2026-06-30 date: 2027-06-30 date: 2024-04-24 date: 2024-04-24 name: International Food Policy Rese... |
<|newrecord|> nctId: NCT06380491 id: REF.2338 id: UNAM-PAPIIT 32-IN216919 type: OTHER domain: Universidad Nacional Autonoma de Mexico (UNAM) briefTitle: Melatonin's Effect on Nighttime Blood Pressure and Sleep in OSA Patients (MEBP-OSA) acronym: MEBP-OSA overallStatus: RECRUITING date: 2023-06-22 date: 2024-11-22 date:... |
The main question it aims to answer is: |
Does melatonin maintain sleep during night and recover the dipping blood pressure pattern? conditions: Obstructive Sleep Apnea of Adult studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients with a non-dipper pattern in blood pressure will rand... |
<|newrecord|> nctId: NCT06380478 id: CPRO-000012 briefTitle: Safety and Efficacy of the Bi-Aspheric Monofocal IOL overallStatus: RECRUITING date: 2024-03-05 date: 2024-12-05 date: 2024-12-25 date: 2024-04-24 date: 2024-04-24 name: ICARES Medicus, Inc. class: INDUSTRY name: AST Products, Inc. briefSummary: This is an ob... |
<|newrecord|> nctId: NCT06380465 id: 23-11-1838 briefTitle: The Effect of Anthocyanin Intake From Purple Sweet Potato in Cerebral Small Vessel Disease overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2025-04-30 date: 2025-04-30 date: 2024-04-24 date: 2024-04-24 name: Indonesia University class: OTHER name: Faku... |
Purple sweet potatoes, scientifically known as Ipomoea batatas (L.) Lam., contains of high anthocyanin specifically peonidin and cyanidin that has antioxidant, anti-inflammatory, and potentially phytoestrogenic activity. These anthocyanins have been linked to a reduced risk of obesity, diabetes, and high cholesterol. T... |
The outcomes that will be assessed are vasomotor reactivity measured by Breath Holding Index in Transcranial Doppler, Nitric Oxide, L-Arginine and Adiponectin levels in blood, Cognitive Test and Gait. conditions: Cerebral Small Vessel Diseases studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionMode... |
<|newrecord|> nctId: NCT06380452 id: SKABUP id: 2023-507925-41-00 type: OTHER domain: EU-Trial-Nr. (EMA) briefTitle: Therapy for Scabies With Two Differently Concentrated Permethrin Creams acronym: SKABUP overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-07 date: 2028-12 date: 2024-04-23 date: 2024-04-23 name:... |
The trial participants will be randomly assigned and blinded to either Permethrin Cream 5% or Permethrin Cream 10%. conditions: Scabies studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The SKABUP study is a prospective, randomized, double-blind, 2... |
<|newrecord|> nctId: NCT06380439 id: 23-10-1763 briefTitle: The Effect of Wrist Ankle Acupuncture on Post-Total Hip Arthroplasty Pain overallStatus: RECRUITING date: 2024-04-23 date: 2024-07 date: 2024-07 date: 2024-04-23 date: 2024-04-29 name: Indonesia University class: OTHER briefSummary: Total hip arthroplasty is o... |
Wrist ankle acupuncture (WAA) is a simpler acupuncture technique, using fewer points, shallow needle insertion and lighter stimulation. Wrist-ankle acupuncture as multimodal analgesia after orthopedic surgery is useful for reducing pain and reduce the incidence of post-surgical side effects. The primary aim of this stu... |
<|newrecord|> nctId: NCT06380426 id: APHP230441 id: IDRCB : 2023-A02003-42 type: OTHER domain: ANSM briefTitle: Real-life Evaluation of WEGOVY (Semaglutide) Treatment in Adults With Monogenic Obesity (ObGeSema) acronym: ObGeSema overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2027-04-30 date: 2027-11-30 date: ... |
More than 60 genes encoding for proteins located in the hypothalamic leptin/melanocortin pathway have been described in the French National Protocol for Diagnostic and Care (PNDS). |
The natural history of monogenic obesity is characterized by an early onset in childhood, with a major increase in weight in adolescence and young adulthood. The worsening of obesity exposes these patients to severe complications. |
Severe obesity and eating disorders have a major impact on the quality of life of the person but also of the family and caregivers. Clinical management is complex and requires comprehensive, specialized and multidisciplinary management. But the usual lifestyle approaches have so far shown disappointing results, similar... |
In this context, evaluating the response to treatment in the particular condition of monogenic obesity is crucial to propose therapeutic options as early as possible to limit weight evolution and its complications. |
GLP-1 (glucagon-like peptide 1) based innovative therapies have recently emerged as a promising option for treatment of obesity and its complications. This is the case for Semaglutide 2.4mg/week (WEGOVY®), developed by Novo Nordisk. However, there is a lack of data to confirm that semaglutide could be also effective in... |
The hypothesis in this study is that treatment with Semaglutide 2.4mg/week (WEGOVY®) could be as effective in monogenic obesities as in common obesity. conditions: Monogenic Obesity studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 175 type: ESTIMATED measure: Change in weight and Body M... |
<|newrecord|> nctId: NCT06380413 id: 78972024.7.0000.5313 briefTitle: Tai Chi Chuan Combined With Walking on Physical and Mental Parameters of Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-05-20 date: 2024-12-31 date: 2025-07-31 date: 2024-04-23 date: 2024-04-23 name: Federal University of Pelotas class: OT... |
Methods: This study is a randomized, single-blinded, two-arm, parallel, superiority trial. Forty older adults between 60 and 75 years old who are not engaged in any systematic strength and aerobic training program will be recruited. Candidates with language and cognitive problems, a history of cardiovascular diseases (... |
Discussion: The conceptual hypothesis is that the intervention training program with Tai Chi Chuan and walking will lead to greater improvements in both physical and mental parameters due to its multi-component character compared to the walking active-control group. conditions: Aging studyType: INTERVENTIONAL phases: N... |
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