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* Would they have more sides effects with higher antibiotics dosages? |
* Would they recover more quickly with higher antibiotic doses? All patients will undergo a blood test upon hospital arrival, including an assessment of renal function. If renal function is normal or diminished, the patient will receive the standard antibiotic dose. Children with increased renal function will be random... |
<|newrecord|> nctId: NCT06293664 id: RAHM-2023-006 briefTitle: Protocol for Alpha MSH Infusion Study in Patients With Type 2 Diabetes acronym: α-MSH & T2DM overallStatus: RECRUITING date: 2024-03-04 date: 2024-04-04 date: 2024-04-04 date: 2024-03-05 date: 2024-03-05 name: Dasman Diabetes Institute class: OTHER briefSum... |
<|newrecord|> nctId: NCT06293651 id: DA4505_AMST_I/IIa briefTitle: Clinical Trial to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DA-4505 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Locally Advanced or Metastatic Solid Tumors overallStatus: NOT... |
<|newrecord|> nctId: NCT06293638 id: 23-1125 briefTitle: Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor acronym: TRaNCE overallStatus: RECRUITING date: 2024-03-25 date: 2026-12-31 date: 2026-12-31 date: 2024-03-05 date: 2024-04-02 name: The Cleveland Clinic class: OT... |
<|newrecord|> nctId: NCT06293625 id: LEPAGE PHRCK 2022-2 briefTitle: Personalising and Refining Neo-adjuvant Chemotherapy in Locally Advanced But Resecable Colon Cancer in the Elderly of 70 Years Old or More acronym: FOxTROT2France overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2032-03 date: 2032-03 date: 2024-0... |
Almost all of these patients undergo surgery, but many do not receive AC due to frailty (following surgery). This particularly affects patients over 70, who represent the majority of patients diagnosed with CC. |
FOxTROT 2, a trial to test the role of NAC in older patients. conditions: Colon Cancer studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 150 type: ESTIMATED name: Folfox name: Surgery measure: DFS (disease Free Survival) sex: ALL m... |
<|newrecord|> nctId: NCT06293612 id: 22/449-3651 id: 2022-I2M-C&T-B-077 type: OTHER_GRANT domain: CAMS Innovation Fund for Medical Sciences (CIFMS) id: 7244398 type: OTHER_GRANT domain: Youth program of Beijing Natural Science Foundation id: Beijing Hope Run Special Fund type: OTHER_GRANT domain: LC2021A12 briefTitle: ... |
* what are the independent risk factors of distant metastasis (DM) in locally advanced rectal cancer (LARC) |
* What is the influence weight of the above factors on the heterochronous metastasis of LARC, and how to build a risk-prediction model |
This study will not affect or interfere with the routine medical diagnosis and treatment of participants, and will not increase the cost and risk of participants. Participant's information is protected and identified by a unique code. conditions: Locally Advanced Rectal Cancer conditions: Distant Metastasis studyType: ... |
<|newrecord|> nctId: NCT06293599 id: P.T.REC/012/003131 briefTitle: Effect of Scapular Stabilization Exercises Versus Virtual Reality Exercises in Basketball Players With Scapular Dyskinesia acronym: SD overallStatus: NOT_YET_RECRUITING date: 2024-03-05 date: 2024-07-30 date: 2024-07-30 date: 2024-03-05 date: 2024-03-0... |
<|newrecord|> nctId: NCT06293586 id: MD-11-2022 briefTitle: Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery overallStatus: RECRUITING date: 2023-12-01 date: 2024-03-30 date: 2024-03-30 date: 2024-03-05 date: 2024-03-05 name: Cairo University class: OTH... |
<|newrecord|> nctId: NCT06293573 id: 012/005031 briefTitle: Whole- Body Vibration Among Egyptian Elderly With Sarcopenia acronym: WBV overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2025-11-29 date: 2025-12-01 date: 2024-03-05 date: 2024-03-05 name: Cairo University class: OTHER briefSummary: To investigate... |
<|newrecord|> nctId: NCT06293560 id: H-49046 id: 5U01EY032403-03 type: NIH link: https://reporter.nih.gov/quickSearch/5U01EY032403-03 briefTitle: Microphthalmia, Anophthalmia, and Coloboma Genetic Epidemiology in Children acronym: MAGIC overallStatus: RECRUITING date: 2022-09-25 date: 2027-09 date: 2027-09 date: 2024-0... |
<|newrecord|> nctId: NCT06293547 id: DIS-2022-295 briefTitle: Clinical Effectiveness and Parental Acceptance of Silver Diamine Fluoride in Preschool Children: A Non-randomized Trial overallStatus: COMPLETED date: 2022-08-10 date: 2023-10-30 date: 2023-12-30 date: 2024-03-05 date: 2024-03-05 name: Cumhuriyet University ... |
<|newrecord|> nctId: NCT06293534 id: PsychThyroid briefTitle: Thyroid Dysfunction in Patients With Major Psychiatric Disorders overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-01-01 date: 2025-02-01 date: 2024-03-05 date: 2024-03-05 name: Assiut University class: OTHER briefSummary: Thyroid dysfunction in ... |
<|newrecord|> nctId: NCT06293521 id: 06091995 briefTitle: Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries overallStatus: NOT_YET_RECRUITING date: 2024-05-16 date: 2024-12-31 date: 2025-01-01 date: 2024-03-05 date: 2024-03-05 name: Cairo University c... |
<|newrecord|> nctId: NCT06293508 id: NMRR ID-22-02616-I2I briefTitle: mHealth Behavioural Intervention to Increase Breast Cancer Screening Rates Among Members of the Public acronym: mBLISS-B overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-07 date: 2025-07 date: 2024-03-05 date: 2024-03-05 name: Clinical Rese... |
Based on this promising prospect, we designed a randomized controlled trial to study the effects of applying persuasive health communication materials to initiate behavior change among a group of Malaysian women. Materials are delivered in the form of a health communication program over a social messaging application t... |
<|newrecord|> nctId: NCT06293495 id: CUT-OUT briefTitle: Incidence of Cut-out Using Intramedullary Nails With Double Cephalic Screw vs. Unique in Pertrochanteric Fractures overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-09-30 date: 2026-04-01 date: 2024-03-05 date: 2024-03-05 name: Puerta de Hierro Univer... |
Participants will be treated using open reduction and internal fixation with a proximal femoral nail. Researchers will compare intramedullary nailing with a single cephalic screw (Gamma nail) and with a double cephalic screw (Chimaera nail) to see the cut-out rate. conditions: Proximal Femoral Fractures studyType: INTE... |
<|newrecord|> nctId: NCT06293482 id: CAM5850 briefTitle: Safety and Effectiveness of Cochlear Implantation in an Expanded Adult Population acronym: ACE overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-12 date: 2028-06 date: 2024-03-05 date: 2024-03-05 name: Cochlear class: INDUSTRY name: NAMSA name: LWB Consu... |
<|newrecord|> nctId: NCT06293469 id: IRB00434587 briefTitle: Accelerated Flap Coverage in Severe Lower Extremity Trauma acronym: FLAP ATTACK overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2029-05 date: 2029-11 date: 2024-03-05 date: 2024-03-08 name: Johns Hopkins University class: OTHER name: McMaster University... |
<|newrecord|> nctId: NCT06293456 id: 23-360 briefTitle: Study of Poetic Dignity Therapy for Sexual and Gender Minority Patients at End of Life overallStatus: ENROLLING_BY_INVITATION date: 2024-01-29 date: 2026-01 date: 2026-01 date: 2024-03-05 date: 2024-03-05 name: Memorial Sloan Kettering Cancer Center class: OTHER b... |
<|newrecord|> nctId: NCT06293443 id: IMU-OP-TT-01 briefTitle: Evaluation of Functionality of Amputees According to the Medicare Functional K Classification System overallStatus: RECRUITING date: 2024-02-15 date: 2024-03-15 date: 2024-04-01 date: 2024-03-05 date: 2024-03-05 name: Medipol University class: OTHER briefSum... |
<|newrecord|> nctId: NCT06293430 id: P002 briefTitle: Registry on Luma Vision's VERAFEYE System (ENLIgHT) acronym: ENLIgHT overallStatus: NOT_YET_RECRUITING date: 2024-09-15 date: 2025-03-15 date: 2025-03-15 date: 2024-03-05 date: 2024-03-07 name: LUMA Vision Ltd. class: INDUSTRY briefSummary: The objective of the stud... |
Results from this study will be used to guide development of the VERAFEYE System. conditions: Atrial Fibrillation conditions: Left Atrial Appendage Closure conditions: Atrial Arrhythmia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 50 type: ESTIMATED name: VERAFEYE System measu... |
<|newrecord|> nctId: NCT06293417 id: HT-EF-01 briefTitle: To Assess With Ezefeno Tab. in Patients With Dyslipidemia and T2DM acronym: ENSEMBLE overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2027-02-01 date: 2027-02-01 date: 2024-03-05 date: 2024-03-07 name: Korea University Anam Hospital class: OTHER briefSum... |
* major adverse cardiovascular events within 48 months of the trial duration |
* microvascular events within 48 months of the trial duration conditions: T2DM (Type 2 Diabetes Mellitus) conditions: Dyslipidemias studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 3958 type: ESTIMATED name: Statin and Ezefeno name: Statin doubling measure: major adverse cardiovas... |
<|newrecord|> nctId: NCT06293404 id: column flexion id: AnkaraCHBilkent type: OTHER domain: AnkaraCHBilkent briefTitle: The Effect of Spinal Column Flexion on Unilaterality of Spinal Anesthesia overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-03-01 date: 2024-04 date: 2024-03-05 date: 2024-03-05 name: Anka... |
<|newrecord|> nctId: NCT06293391 id: 2022-11/2097 briefTitle: The Effect of Patient Position Changes on Advanced Cardiac Indices in Cancer Surgery overallStatus: COMPLETED date: 2023-02-01 date: 2023-03-01 date: 2024-02-05 date: 2024-03-05 date: 2024-03-05 name: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Res... |
<|newrecord|> nctId: NCT06293378 id: Pengmingli briefTitle: Safety and Effectiveness of Sulfasalazine in the Treatment of Liver Fibrosis/Cirrhosis. overallStatus: RECRUITING date: 2024-02-28 date: 2028-10-10 date: 2028-11-10 date: 2024-03-05 date: 2024-04-02 name: The Second Affiliated Hospital of Chongqing Medical Uni... |
<|newrecord|> nctId: NCT06293365 id: CVAY736A2202 id: 2023-508996-35 type: EUDRACT_NUMBER briefTitle: Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease overa... |
A second optional cohort may be included with the objective of demonstrating the comparability of pharmacokinetics of ianalumab between 1 x 2 mL Pre-filled Syringe (PFS) and 2 x 1 mL PFS. conditions: Sjögrens Disease conditions: Systemic Lupus Erythematosus conditions: Rheumatoid Arthritis studyType: INTERVENTIONAL pha... |
<|newrecord|> nctId: NCT06293352 id: STU00220012 briefTitle: Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2026-12 date: 2024-03-05 date: 2024-03-05 name: Northwestern University class: OTHER briefSummary: In the U... |
There is another way for artificial joint infections to be treated. This is a one-stage revision. In this treatment, the surgeon will remove your artificial knee and clean out the area around the knee. Then they will place a new artificial knee in using a special kind of cement that contains antibiotics. The cement wil... |
We know that both the one- and two-stage revision work equally well to heal the infection, but we don't know which patients prefer or which provides better function after many years. This study will randomly assign patients to receive either a one-stage or two-stage revision and then follow them for 5 years to ask them... |
<|newrecord|> nctId: NCT06293339 id: CoGA-Re briefTitle: Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge) overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-11-01 date: 2025-05-31 date: 2024-03-05 date: 2024-03-05 name: Leiden University Medical Center class: OTHER b... |
<|newrecord|> nctId: NCT06293326 id: 22553 briefTitle: A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male Participants overallStatus: RECRUITING date: 2024-03-06 date: 2024-06-06 date: 2024-06-06 date: 2... |
Calcium carbonate tablets are used to treat heartburn, indigestion, and related digestive problems. Calcium carbonate works by neutralizing the excess acid in the stomach. The study treatment is a new bi-layer calcium carbonate tablet that has two layers. One layer quickly releases calcium carbonate aimed to provide qu... |
In this study, bi-layer calcium carbonate tablets will be given to healthy men for the first time. This study will provide information on how the new bi-layer tablet works inside the body. |
The main purpose of this study is to learn about how the new bi-layer calcium carbonate tablet changes the average acidity levels (measured using pH) compared to the standard calcium carbonate tablet during the night-time. |
For this, researchers will measure the acidity levels in the upper part of the stomach at regular intervals during the night-time. |
The participants will be randomly (by chance) assigned to one of two treatment groups: |
Participants in the first group will take the treatments at night. |
Participants in the second group will take the treatments during the day. |
All participants in both groups will take 2 bi-layer tablets and 2 standard tablets after a meal with a gap of 6 to 8 days between treatments. However, in each group, half the participants will receive the bi-layer tablets first while the other half will receive the standard tablets first. |
Each participant will be in the study for around 52 days with up to 4 visits to the study site. This includes: |
1. visit about 28 days before the treatment starts during which the doctors will confirm that the participant can take part in the study |
2. visits for treatment with a gap of 6-8 days between each treatment, and |
1 visit 7 to 14 days after the treatment ends during which the doctors will monitor the participants' health. |
During the study, the doctors and their study team will: |
check participants' overall health by performing tests such as blood and urine tests, and check heart health using an electrocardiogram (ECG) |
take images of the stomach at different times after taking the treatment |
measure acidity level (pH) using a device called pH probe that is inserted into the upper part of the stomach |
ask the participants questions about how easy it is to take the study treatment |
ask the participants what adverse events they are having. |
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective of whether they think it is related to the study treatment, or not. |
As this study is conducted in healthy men who will not gain any benefit from this treatment, access to the study treatment after the study is not planned. conditions: Heartburn conditions: Indigestion conditions: Stomach Acid Related Symptoms conditions: Nocturnal Stomach Acid Related Symptoms conditions: Healthy Volun... |
<|newrecord|> nctId: NCT06293313 id: Inonu-SBF-SO-03 briefTitle: The Effect of Mindfulness Practice on Coping With Primary Dysmenorrhea on Pain and Anxiety Level overallStatus: RECRUITING date: 2024-02-28 date: 2024-04-28 date: 2024-08-28 date: 2024-03-05 date: 2024-03-05 name: Inonu University class: OTHER briefSummar... |
<|newrecord|> nctId: NCT06293300 id: 20231056 id: HT94252310608 type: OTHER_GRANT domain: Department of Defense Awarding Office: U.S. Army Medical Research Acquisition Activity (USAMRAA) briefTitle: Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A) overa... |
<|newrecord|> nctId: NCT06293287 id: DJ-2023-02 briefTitle: Enoxaparin for Preventing the Radical Artery Occlusion After the Transradial Access Hepatic Arterial Infusion Chemotherapy overallStatus: RECRUITING date: 2024-01-31 date: 2024-11-30 date: 2025-01-30 date: 2024-03-05 date: 2024-03-08 name: Zhongshan Hospital (... |
<|newrecord|> nctId: NCT06293274 id: sdilek5 briefTitle: The Importance of Discharge Education for Mommy Blues overallStatus: RECRUITING date: 2024-01-01 date: 2024-03-30 date: 2024-05-30 date: 2024-03-05 date: 2024-03-22 name: Kocaeli University class: OTHER briefSummary: The study will be conducted with participants ... |
The sample size of the study was calculated using the G\*Power 3.1.9.2 program, and the effect size of the Edinburgh Postnatal Depression Scale (EPDS) score in the Sun et al. (2021) study was considered in the effect size calculation. In the relevant article, the effect size is reported as effect size: 0.47. In our pla... |
<|newrecord|> nctId: NCT06293261 id: YMC043 briefTitle: Multicenter, Prospective, Non-interventional, Observational Study to Confirm the Long-term Efficacy and Safety of Rosuampin Tab. in Patients With Hypertension and Hypercholesterolemia overallStatus: ACTIVE_NOT_RECRUITING date: 2020-06-27 date: 2024-03-31 date: 202... |
<|newrecord|> nctId: NCT06293248 id: 77979112 briefTitle: Music Application in Patients Undergoing Percutaneous Coronary Intervention overallStatus: ACTIVE_NOT_RECRUITING date: 2023-07-10 date: 2023-12-31 date: 2024-05-31 date: 2024-03-05 date: 2024-03-12 name: Kocaeli University class: OTHER briefSummary: This study w... |
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