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Based on previous studies and by analogy with other neurological diseases, the investigators hypothesize that autonomic dysfunction following AIS contributes to PSF and that patients presenting heart failure as a complication following AIS have an increased risk of PSF. |
To confirm this hypothesis, the investigators will conduct a prospective, interventional study where patients who are hospitalized at the Stroke Unit, within 72 hours after stroke symptom onset, will be included. Evaluation will take place of (a) the relationship between autonomic dysfunction (HRV) and early and late P... |
There will also be an investigation into following elements: |
* the association between early and late PSF and (a) certain inflammatory markers at admission (CRP, NLR), (b) stroke localization and (c) baseline imaging markers of brain frailty. |
* the role of pre-existing fatigue + pre-existing or post-stroke newly diagnosed cognitive impairment, depression and sleep disturbances on the course of PSF. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: BASIC_SCIENCE masking: NONE count: 250 typ... |
<|newrecord|> nctId: NCT06292364 id: PGIDS/BHRC/23/106 briefTitle: Comparison of Retention Characteristics of Immediate vs Delayed Retainer Delivery Using 3D Digital Model Analysis overallStatus: RECRUITING date: 2023-11-05 date: 2024-11-05 date: 2024-12-05 date: 2024-03-05 date: 2024-03-05 name: Postgraduate Institute... |
<|newrecord|> nctId: NCT06292351 id: DMBN_ALZH-2022-II briefTitle: DMB-I in the Treatment of Alzheimer Type Dementia overallStatus: RECRUITING date: 2023-12-27 date: 2024-12-21 date: 2024-12-21 date: 2024-03-05 date: 2024-03-20 name: Bigespas LTD class: INDUSTRY briefSummary: The purpose of this study is to assess the ... |
<|newrecord|> nctId: NCT06292338 id: AUCHAU briefTitle: Lung Sonar in Neonatal Respiratory Disorders overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-05-01 date: 2024-03-05 date: 2024-03-05 name: Gehad Adel Mohammed Hussein class: OTHER briefSummary: This study aimed to determine the value... |
<|newrecord|> nctId: NCT06292325 id: FDG_88-17 briefTitle: Psychological Aspects in OSA acronym: PSICOSA overallStatus: ENROLLING_BY_INVITATION date: 2023-05-08 date: 2023-05-08 date: 2024-05-31 date: 2024-03-05 date: 2024-03-07 name: Fondazione Don Carlo Gnocchi Onlus class: OTHER name: Catholic University of the Sacr... |
The research aims to explore the perception and awareness of the disease and its impact on the individual and couple's lives of patients with OSA and their bed partners, to assess patients' perceptions of the disease and symptoms, as well as their bed partners' perceptions. Moreover, psychological aspects of living wit... |
<|newrecord|> nctId: NCT06292312 id: 19.12.2023/10-483 briefTitle: Investigation of the Effectiveness of Craniosacral Therapy in Patients With Multiple Sclerosis. overallStatus: RECRUITING date: 2024-02-27 date: 2025-04-15 date: 2025-05-15 date: 2024-03-05 date: 2024-03-05 name: Ankara Yildirim Beyazıt University class... |
In the treatment of many neurological diseases such as Multiple Sclerosis, complementary medicine practices and non-traditional therapies have recently been shown to be effective in addition to conventional practices. One of these practices, craniosacral therapy (CST), uses manual palpation and manipulation of the cran... |
<|newrecord|> nctId: NCT06292299 id: INGN22RM471P id: 10072600 type: OTHER_GRANT domain: PneumoWave Ltd & Innovate UK briefTitle: The PARS Study: Paediatric Advanced Respiratory Service Study - An Observational Diagnostic Feasibility Study acronym: PARS overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-12 d... |
Infants in the neonatal period can have immature breathing control which manifests as excessive central breathing pauses, apnoea's, whilst asleep requiring oxygen therapy. There is also a risk to newborn term infants of sudden unexpected neonatal collapse, even in "low risk" babies. Diagnosis of breathing issues in bab... |
This observational study is part of a phased clinical program of research that aims to validate a small wearable biosensor developed by PneumoWave Ltd in a paediatric clinical setting with the overall primary endpoints of monitoring and assessing respiratory pattern as an aid to sleep diagnostics, and as a device to mo... |
<|newrecord|> nctId: NCT06292286 id: UW 22-704 briefTitle: Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer acronym: SCENIC overallStatus: RECRUITING date: 2023-11-01 date: 2025-12-31 date: 2026-07-01 date: 2024-03-05 date: 2024-03-05 name: The University of Hong Kong c... |
<|newrecord|> nctId: NCT06292273 id: ANET19 briefTitle: Bupivacaine With Dexmedetomidine Versus Bupivacaine Alone for Transversus Abdominis Plane Block in Caesarean Section overallStatus: COMPLETED date: 2023-10-10 date: 2024-02-01 date: 2024-02-20 date: 2024-03-05 date: 2024-03-05 name: Menoufia University class: OTHE... |
<|newrecord|> nctId: NCT06292260 id: 2020-2054-2 briefTitle: Digital Toolkit for Skin Diseases in LMICs: Part 2 acronym: MIND-the-SKIN2 overallStatus: RECRUITING date: 2024-03-18 date: 2026-05-31 date: 2026-05-31 date: 2024-03-05 date: 2024-04-17 name: Tulane University class: OTHER name: Hope Commission International ... |
<|newrecord|> nctId: NCT06292247 id: A0503023 briefTitle: Effectiveness of CBT and APT on Managing Child Anxiety in Dental Office overallStatus: ACTIVE_NOT_RECRUITING date: 2023-06-01 date: 2023-10-23 date: 2024-05-01 date: 2024-03-05 date: 2024-03-07 name: Mansoura University class: OTHER briefSummary: This study was ... |
<|newrecord|> nctId: NCT06292234 id: OMFS briefTitle: Patient Specific Implant Versus Miniplates for Advancement of Hypoplastic Maxilla overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-02-01 date: 2025-03-01 date: 2024-03-05 date: 2024-04-19 name: Cairo University class: OTHER briefSummary: Distraction ost... |
<|newrecord|> nctId: NCT06292221 id: H19-078 id: R01MH119678 type: NIH link: https://reporter.nih.gov/quickSearch/R01MH119678 briefTitle: Personalized Depression Treatment Supported by Mobile Sensor Analytics acronym: DepWatch overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-04 date: 2025-06 date: 2024-03-05 ... |
1. Feasibility of the digital tool, DepWatch, to assist clinicians in depression treatment and inform their clinical decision process |
2. Effectiveness of the digital tool, DepWatch, to improve depression treatment outcomes All study participants will carry the DepWatch app on their smartphones and wear a Fitbit provided by the study team during the study period. They will also complete brief questionnaires via the app at specific time intervals throu... |
<|newrecord|> nctId: NCT06292208 id: IBD0333-101 briefTitle: A Clinical Trial to Evaluate Effect of IBD0333 in Patients With Advanced Malignant Tumors overallStatus: NOT_YET_RECRUITING date: 2024-03-02 date: 2029-12-31 date: 2030-12-31 date: 2024-03-05 date: 2024-03-05 name: SUNHO（China）BioPharmaceutical CO., Ltd. clas... |
Dose expansion phase To evaluate the safety and tolerability of IBD0333 in patients with locally advanced/metastatic solid tumor or non-Hodgkin lymphoma and to determine the recommended Phase 2 dose (RP2D). |
Clinical exploration phase To evaluate the preliminary efficacy of IBD0333 in patients with specific tumor. |
Secondary objectives Dose escalation phase \& Dose expansion phase To evaluate the pharmacokinetic (PK) of IBD0333 in patients with locally advanced/metastatic solid tumor or non-Hodgkin lymphoma; To evaluate the immunogenicity of IBD0333 in patients with locally advanced/metastatic solid tumor or non-Hodgkin lymphoma;... |
Clinical exploration Phase To evaluate the safety and tolerability of IBD0333 in patients with specific tumor; To evaluate the immunogenicity of IBD0333 in patients with specific tumor. Exploratory Objectives To explore biomarkers in blood and tissue that predict potential efficacy of IBD0333. conditions: MTD studyType... |
<|newrecord|> nctId: NCT06292195 id: VitDTracking briefTitle: Effects of Vitamin D on Health Promotion During Pregnancy and Its Impact on Prematurity-Related Outcome acronym: VitDTracking overallStatus: RECRUITING date: 2023-11-03 date: 2024-12-31 date: 2025-12-31 date: 2024-03-05 date: 2024-03-05 name: University of É... |
The hypovitaminoses prevalence remains high even with a supplementation dosage of 400 to 600 IU/day during pregnancy (dosage used in Portugal), which is considered as a suboptimal dose. This phenomenon is associated with adverse maternal and child outcomes, such as intrauterine growth restriction, preeclampsia, cholest... |
Additionally, the Portuguese population has a higher prevalence of genome alterations that confer a lower capacity to produce vitamin D from sunlight exposure. These genetic characteristics are present in about 19% of the population, representing a prevalence four times higher than the European average (19% versus 4.75... |
<|newrecord|> nctId: NCT06292182 id: 160802 id: 332942 type: OTHER domain: IRAS id: 58964 type: OTHER domain: CPMS briefTitle: Red Light Ptosis Proof-of-Concept overallStatus: RECRUITING date: 2024-02-08 date: 2025-11-30 date: 2025-11-30 date: 2024-03-05 date: 2024-03-05 name: University College, London class: OTHER na... |
We use a torch to shine a red light through the closed eyelid for 3 minutes a day. The study will run for 18 months. |
We believe that this treatment could help strengthen the muscle in the eyelid to make it easier to open the eyes, and could also help some children with squint. conditions: Mitochondrial Diseases conditions: Blepharoptosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SEQUENTIAL primary... |
<|newrecord|> nctId: NCT06292169 id: STUDY00007201 briefTitle: Pectoralis Minor Release Versus Non-release in RSA overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-01 date: 2026-01 date: 2024-03-05 date: 2024-04-09 name: Emory University class: OTHER briefSummary: The goal of this clinical trial is to assess i... |
* whether releasing the pectoralis minor prophylactically could have better pain relief |
* whether releasing the pectoralis minor prophylactically could have increased Range of motion (ROM) outcomes |
* whether releasing the pectoralis minor prophylactically could have higher final Patient Reported Outcome Measurements (PROMs) Participants will be randomized to either undergo RSA with pectoralis minor release or RSA without pectoralis minor release. conditions: Reverse Total Shoulder Arthroplasty conditions: Rotator... |
<|newrecord|> nctId: NCT06292156 id: CASPsy7 briefTitle: tACS Treatment for Cognitive Impairments in Methamphetamine Addicts overallStatus: RECRUITING date: 2023-02-20 date: 2024-08 date: 2024-08 date: 2024-03-04 date: 2024-03-04 name: Beijing HuiLongGuan Hospital class: OTHER briefSummary: 1. To evaluate the cognitive... |
2. Investigate the pathological mechanism of methamphetamine patients from the aspects of EEG and biology; |
3. The investigators investigated the effects of transcranial alternating current stimulation (tACS) on cognitive impairments in methamphetamine patients conditions: Methamphetamine Abuse studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE wh... |
<|newrecord|> nctId: NCT06292143 id: EU101136769-CLIN2 briefTitle: AI4HOPE Dementia Care Planning Pilot Study 2 ( AI4HOPE2) acronym: AI4HOPE-P2 overallStatus: NOT_YET_RECRUITING date: 2025-07 date: 2026-12 date: 2026-12 date: 2024-03-04 date: 2024-03-04 name: University of Bonn class: OTHER name: University College Cor... |
<|newrecord|> nctId: NCT06292130 id: 156588-01 briefTitle: Health-Kit Enabled Mobile App for Tobacco Cessation overallStatus: COMPLETED date: 2022-03-21 date: 2023-09-21 date: 2023-09-21 date: 2024-03-04 date: 2024-03-04 name: Pro-Change Behavior Systems class: OTHER briefSummary: Tobacco use remains the leading preven... |
This Phase I SBIR will explore the acceptability and effects of one such innovative health IT solution. Refresh is a highly individualized tobacco cessation HealthKit enabled app that will 1) implement a full range of best practices in tailored health behavior change communications based on readiness to change; 2) indi... |
Extensive end user and stakeholder input will ensure refresh is designed for rapid dissemination. Patients of an integrated delivery system with an upcoming appointment (n=100) will be recruited to participate in a 30-day pilot test. Pilot participants will provide quantitative and qualitative data, and utilization and... |
<|newrecord|> nctId: NCT06292117 id: 230247 briefTitle: Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke acronym: ORCA-AIS overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-06 date: 2026-06 date: 2024-03-04 date: 2024-03-04 name: University ... |
The main questions this study aims to answer are: |
* What are the best strategies to implement this genetic test in the hospital? |
* Does implementation of this genetic test change providers' decisions on which medication to prescribe after a participant has a stroke? |
Participants in this study will have a genetic test done onsite looking for variations in the section of DNA that tells the body how to make CYP2C19. This genetic test will only look for 11 known variations; the genome will not be sequenced. The investigators will alert the doctor of the patient's test results so they ... |
<|newrecord|> nctId: NCT06292104 id: STU-2023-0589 id: 1R01HL166272-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/1R01HL166272-01A1 briefTitle: Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS) overallStatus: RECRUITING date: 2024-03-05 date: 2028-12 date: 2029-01 date: 2024-03-04 date: 2024-0... |
<|newrecord|> nctId: NCT06292091 id: Ur_ABD_PK briefTitle: A Study to Investigate the Effect of Urine Acid-base Disequilibrium on the Pharmacokinetics of Captopril overallStatus: COMPLETED date: 2024-02-28 date: 2024-03-27 date: 2024-04-01 date: 2024-03-04 date: 2024-04-17 name: Seoul National University Hospital class... |
<|newrecord|> nctId: NCT06292078 id: 1R01DA059401-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01DA059401-01 id: 1R01DA059401-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01DA059401-01 briefTitle: Preventing School Exclusion and Opioid Misuse: Effectiveness of the Inclusive Skill-building Lear... |
<|newrecord|> nctId: NCT06292065 id: Project ID 6171 briefTitle: Gastric Ultrasound To Assess Gastric Contents In Patients On Semaglutide Therapy acronym: GUST overallStatus: RECRUITING date: 2024-04-14 date: 2024-12-31 date: 2024-12-31 date: 2024-03-04 date: 2024-04-05 name: Nils Vlaeminck class: OTHER briefSummary: G... |
One of the mechanisms by which weight loss is achieved, is increased satiety and significantly delayed gastric emptying. Tachyphylaxis for this effect has been reported with chronic use of long acting GLP-1-RA (e.g. semaglutide) but this was based on the paracetamol absorption technique or 13C breath test. Recent clini... |
To address this issue the American Society of Anesthesiologists (ASA) has recently released guidelines in which it advises to hold GLP-1-RA for one day (if administered daily) or one week (if administered weekly). |
However, these recommendations are based on sparse empirical evidence and they do not necessarily follow from the known pharmacokinetic properties of these drugs. Typically, GLP-1-RA are administered in increasing doses over several weeks until a therapeutic steady state is achieved. Meanwhile the elimination half-life... |
Further confounding the assessment of these patients there can be 'background' delayed gastric emptying in diabetic patients and more pronounced delayed gastric emptying in patients recently started on GLP-1-RA. The presence of gastro-intestinal symptoms (nausea, vomiting, dyspepsia, abdominal distension) might offer c... |
Gastric ultrasound is a point-of-care clinical and research tool that has steadily gained popularity to assess gastric content in patients not compliant with fasting rules or with certain comorbidities. Clinical decisions can be made based on the visualised content (e.g. solids, fluids or nothing) or through calculatio... |
<|newrecord|> nctId: NCT06292052 id: NSCLC-TDLN-001 briefTitle: Relation Between Tumor-draining Lymph Nodes Metastasis Pattern and Non-small Cell Lung Cancer Neoadjuvant Immunotherapy Effectiveness overallStatus: RECRUITING date: 2017-01-01 date: 2024-03-01 date: 2024-04-01 date: 2024-03-04 date: 2024-03-04 name: Sun Y... |
<|newrecord|> nctId: NCT06292039 id: P0555788 id: 2KL2TR001870 type: NIH link: https://reporter.nih.gov/quickSearch/2KL2TR001870 briefTitle: Human-centered Injury Thrivorship Pathway for Survivors of Physical Trauma overallStatus: NOT_YET_RECRUITING date: 2025-07 date: 2026-04 date: 2026-06 date: 2024-03-04 date: 2024-... |
• Is the pathway appropriate, acceptable, and feasible to meet the medical and social needs of injury survivors? |
Injury survivors will be purposively sampled to enroll in the pathway and asked to participate in in-depth interviews and their use of pathway resources will be tracked. conditions: Injury Traumatic conditions: Survivorship conditions: Trauma Injury studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel:... |
<|newrecord|> nctId: NCT06292026 id: DFU/1 briefTitle: Efficacy of ProgenaMatrix™ in the Management of DFUs overallStatus: ACTIVE_NOT_RECRUITING date: 2022-03-14 date: 2026-03 date: 2026-09 date: 2024-03-04 date: 2024-03-04 name: ProgenaCare Global, LLC class: INDUSTRY briefSummary: This multicenter study will collect ... |
<|newrecord|> nctId: NCT06292013 id: 18812 id: J3L-MC-EZEF type: OTHER domain: Eli Lilly and Company id: 2023-509190-23 type: EUDRACT_NUMBER briefTitle: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) overall... |
<|newrecord|> nctId: NCT06292000 id: 23-1721 briefTitle: Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes acronym: TExIS overallStatus: RECRUITING date: 2024-02-01 date: 2026-06 date: 2026-06 date: 2024-03-04 date: 2024-03-29 name: University of Colorado, Denver cla... |
Procedures: |
* 2 screening visits to make sure you are eligible to be in the study. This will include a fasting blood draw and heart tracing (EKG). |
* If you are eligible, you will complete both exercise conditions in a random order. All participants in the study will complete the following separated by 3-4 weeks: |
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