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The traditional toothbrush group and the U-shaped toothbrush group, All children aged four to five years will have their plaque assessed with the Turesky Modified Quigley Hein Index (TMQH) conditions: Dental Plaque studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: P... |
<|newrecord|> nctId: NCT06288568 id: Shift2Health briefTitle: Night Shift Work and Biomarkers of Obesity Risk in Hospital and Industry Workers acronym: Shift2Health overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-05-01 date: 2028-05-31 date: 2024-03-01 date: 2024-03-05 name: University of Vienna class: OT... |
The investigators aim to characterize the behavioural, environmental, and biological mechanisms and pathways for the association of night shift work and obesity across Europe. |
The investigators will conduct a cross sectional study in 5 European countries (Austria, Denmark, Germany, Netherlands and Poland) and recruit 1000 rotating night shift workers and day workers (200/country) from the health sector and different industries. Night and day workers will be age-frequency (3 age groups), gend... |
<|newrecord|> nctId: NCT06288555 id: 020/2566 briefTitle: Validation of Ipswich Touch Test for Diabetic Peripheral Neuropathy Screening in Primary Care overallStatus: COMPLETED date: 2023-12-21 date: 2024-01-23 date: 2024-01-23 date: 2024-03-01 date: 2024-03-05 name: Ponlawat Hanchana, MD class: OTHER_GOV briefSummary:... |
The main question it aims to answer is: |
How does the accuracy of the Ipswich Touch Test for identifying peripheral neuropathy compare to the traditional 10-g monofilament test? |
Participants underwent both the Ipswich touch test and the 10-g monofilament test. conditions: Diabetic Foot studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL count: 274 type: ACTUAL name: Ipswich touch test measure: The accuracy of the Ipswich touch test sex: ALL minimumAge: 18... |
<|newrecord|> nctId: NCT06288542 id: MD-250-2022 briefTitle: Preoperative Dextrose Infusion and Postoperative Nausea and Vomiting overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-05-01 date: 2024-05-01 date: 2024-03-01 date: 2024-03-01 name: Cairo University class: OTHER briefSummary: This research aims to... |
<|newrecord|> nctId: NCT06288529 id: 1 briefTitle: EFFECT SGLT2 INHIBITORS ON CONTRAST MEDIUM INDUCED ACUTE KIDNEY INJURY overallStatus: COMPLETED date: 2023-07-15 date: 2023-12-31 date: 2024-01-31 date: 2024-03-01 date: 2024-03-01 name: University of Health Sciences Balikesir Hospital Eduation and Research class: OTHE... |
In our study we found that SGLT2 inhibitors are beneficial in terms of reducing contrast media induced acute kidney injury in both diabetic and CKD patients.This is one of the leading studies in the literature pointing that SGLT2 inhibitors may have a potentially beneficial role in reducing or preventing the developmen... |
<|newrecord|> nctId: NCT06288516 id: 7484 briefTitle: BenRalizumab Effect on Airway Remodeling in Severe asTHma acronym: BREATH overallStatus: RECRUITING date: 2024-03-01 date: 2025-12-31 date: 2026-06-01 date: 2024-03-01 date: 2024-03-04 name: Aristotle University Of Thessaloniki class: OTHER name: Pulmonary Clinic, A... |
Aim of this clinical study is to evaluate the efficacy of benralizumab, a humanized an anti-interleukin 5 receptor α monoclonal antibody in patients with severe eosinophilic asthma and to evaluate airway remodeling before and after benralizumab treatment. |
Hypothesis Identification of pathological and clinical characteristics in patients with severe eosinophilic asthma after benralizumab treatment regarding the airway remodeling, inflammatory cells, and other biomarkers on a long-term basis. |
Research questions Is there any improvement in airway remodeling? Are there any biomarkers to predict response to benralizumab treatment in severe eosinophilic asthmatic patients? conditions: Asthma; Eosinophilic conditions: Airway Remodeling studyType: INTERVENTIONAL phases: PHASE4 allocation: NON_RANDOMIZED intervent... |
<|newrecord|> nctId: NCT06288503 id: HRF2023 briefTitle: Hydrolysed Rice Formula Study overallStatus: RECRUITING date: 2024-02-01 date: 2027-07 date: 2027-07 date: 2024-03-01 date: 2024-03-01 name: Nutricia UK Ltd class: INDUSTRY briefSummary: This non-inferiority study aims to determine whether a hydrolysed rice prote... |
<|newrecord|> nctId: NCT06288490 id: AMCS-009 briefTitle: A Single Arm Study Comparing ACC Supplement to CCS in Management of Hypoparathyroidism acronym: AMCS009 overallStatus: TERMINATED date: 2013-04 date: 2014-06 date: 2014-06-25 date: 2024-03-01 date: 2024-03-01 name: Amorphical Ltd. class: INDUSTRY briefSummary: P... |
Phase I Proof of concept: treatment with smaller doses of elemental calcium from ACC compared to CCS can maintain target serum calcium (corrected for albumin) values (7.0-10.0 mg/dL). |
Phase II To test the hypothesis that treatment with smaller doses of elemental calcium from ACC compared to CCS can maintain target serum calcium (corrected for albumin) values (7.0-10.0 mg/dL). |
Secondary objectives: |
Phase I |
* ACC dose selection - to confirm the conversion factor of ACC from CCS |
* To determine the effect of food on ACC absorption |
Phase II |
* To test the hypothesis that treatment with smaller doses of elemental calcium from ACC compared to CCS will not cause an increase in hypercalciuria in patients with hypoparathyroidism |
* To test the hypothesis that smaller doses of elemental calcium from ACC can reduce the side effects related with high calcium consumption. |
Amorphical has a strong basis to believe that the ACC product is better absorbed compared to the commercially available CCS products and therefore, can maintain desirable target albumin corrected calcium values in serum (CA) with smaller doses of elemental calcium from ACC. As results, the burden of taking high doses o... |
Testing serum CA and urine calcium values in subjects with hypoparathyroidism may provide a straightforward method to test this hypothesis. |
The study is designed to be conducted with extra precaution in order to avoid disturbing the fragile balance between CA levels in serum and calcium levels urine. The crossover design of phase II of the study allows a more accurate and reliable comparison of results attributable to the specific treatment within the same... |
<|newrecord|> nctId: NCT06288477 id: 2023-2 briefTitle: Clinical and Radiographic Evaluation of Vital Pulpotomy Techniques in Primary Molars Using of Premixed Bioactive Bioceramic MTA (Neo-putty) as a Novel Pulpotomy Medication Versus Formocresol overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-05-01 date:... |
<|newrecord|> nctId: NCT06288464 id: 315656 id: 22/WM/0222 type: OTHER domain: Health Research Authority briefTitle: Enteral Feeding of Fibre to Improve Microbiota overallStatus: RECRUITING date: 2023-01-09 date: 2025-12-01 date: 2025-12-01 date: 2024-03-01 date: 2024-03-01 name: Lancashire Teaching Hospitals NHS Found... |
<|newrecord|> nctId: NCT06288451 id: STUDY00018021 id: 1K23DK136930-01 type: NIH link: https://reporter.nih.gov/quickSearch/1K23DK136930-01 briefTitle: DePTH: De-emphasize PTH overallStatus: RECRUITING date: 2024-03-11 date: 2027-02-28 date: 2027-02-28 date: 2024-03-01 date: 2024-03-18 name: University of Washington cl... |
<|newrecord|> nctId: NCT06288438 id: E5012-R id: 23-2306 type: OTHER domain: COMIRB briefTitle: Multicomponent Telerehabilitation to Engage Veterans in Effective Self-Management of Complex Health Conditions overallStatus: RECRUITING date: 2024-04-01 date: 2026-11-02 date: 2028-03-31 date: 2024-03-01 date: 2024-04-08 na... |
<|newrecord|> nctId: NCT06288425 id: SPACE-KIT briefTitle: Spatial Transcriptomics in Kidney Transplantation acronym: SPACE-KiT overallStatus: ENROLLING_BY_INVITATION date: 2024-04-03 date: 2030-01-01 date: 2035-01-01 date: 2024-03-01 date: 2024-04-24 name: Western Sydney Local Health District class: OTHER briefSummary... |
The central hypothesis for this study is that spatial data will reveal new insights to immune cell function and local interactions within the kidney tissue to better predict important clinical outcomes. Investigators aspire to establish a prospective, longitudinal cohort to improve the diagnosis and management of kidne... |
By utilising new spatial technologies, the investigators aim to: |
* Derive a spatially resolved transcriptomic signature of kidney transplant rejection subtypes |
* Derive accurate transcriptomic signatures aligned with key cell types within the transplant kidney |
* Develop refinements to histological kidney rejection diagnostic and scoring classification |
* Correlate of spatial and refined biopsy scoring features to clinically important outcomes conditions: Transplant Complication conditions: Kidney Injury studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED name: Non interventional measure: Kidney biopsy features m... |
<|newrecord|> nctId: NCT06288412 id: NN1436-7615 id: U1111-1285-1665 type: OTHER domain: World Health Organization (WHO) id: 2023-505012-38 type: OTHER domain: European Medical Agency (EMA) briefTitle: A Study to Test How a New Long-acting Insulin Works in the Body of Patients With Type 2 Diabetes During Exercise and P... |
<|newrecord|> nctId: NCT06288399 id: DAS-7688 id: U1111-1292-7248 type: OTHER domain: World Health Organization (WHO) briefTitle: Prevalence and Economic Burden of Obesity-related Comorbidities in the Gulf Region: A Retrospective, Observational Study overallStatus: ENROLLING_BY_INVITATION date: 2023-12-21 date: 2024-06... |
<|newrecord|> nctId: NCT06288386 id: 2024-ATTACHMENTS briefTitle: Influence of Different Nanohybrid Flowable Composite Resin on Shear Bond Strength and Dimensional Changes of Invisalign Attachments After 6 Months of Brushing overallStatus: ENROLLING_BY_INVITATION date: 2024-03-04 date: 2025-02 date: 2025-02 date: 2024-... |
* group A: Filtek Supreme Flow (3M Unitek, Monrovia, Calif) |
* group B: Grandioso Heavy Flow (VOCO GmbH, Cuxhaven Germany) |
Digital impressions with iTero intraoral scanner will be performed; digital impressions will be performed after 3 months (T1) and 6 months (T2) from the baseline. |
Digital scans will be used to assess any changes in shape and volume of the attachments per each different time frame. Each tooth will be separated from the others and superimpositions of the single tooth will be performed with ZEISS Inspect software. |
After attachments placement, the clinicians will be asked to answer, on a scale from 1 to 10, to this questionnaire's questions about the two different flowable composites; each question is repeated for each composite resin. |
Type of brushing (with manual or electric toothbrush) and hand of brushing will be recorded. conditions: Malocclusion studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Split-mouth design primaryPurpose: BASIC_SCIENCE masking: DOUBLE whoMasked: PARTICIP... |
<|newrecord|> nctId: NCT06288373 id: NACI-CERV-003 briefTitle: Neoadjuvant Chemoimmunotherapy Versus Concurrent Chemoradiotherapy for LACC overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2031-03-01 date: 2031-03-01 date: 2024-03-01 date: 2024-03-01 name: Tongji Hospital class: OTHER name: Southwest Hospital, C... |
<|newrecord|> nctId: NCT06288360 id: NACI-CERV-002 briefTitle: Neoadjuvant Immunochemotherapy in PD-L1-negative LACC overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-12-31 date: 2030-12-12 date: 2024-03-01 date: 2024-03-01 name: Tongji Hospital class: OTHER name: Southwest Hospital, China name: Women Hospi... |
<|newrecord|> nctId: NCT06288347 id: 216099 briefTitle: Study of the Efficacy of GGON: a Cognitive Training App for Orthorexia Nervosa. overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2024-06-17 date: 2024-06-17 date: 2024-03-01 date: 2024-03-15 name: University of Valencia class: OTHER briefSummary: The aim o... |
The experimental group started using the app for 15 days, and later completed the following assessment (T2). The control group also completed the T2 in the same date but started to use the app after this second assessment.15 days and one month later, both groups completed T3 and T4. primaryPurpose: PREVENTION masking: ... |
<|newrecord|> nctId: NCT06288334 id: PUTH PD_V 1.2 briefTitle: Exploration of the Optimal Dosage of Cetirizine in the Treatment of Allergic Diseases in Chinese Children overallStatus: RECRUITING date: 2020-08-06 date: 2024-03-31 date: 2024-05-31 date: 2024-03-01 date: 2024-03-01 name: Peking University Third Hospital c... |
<|newrecord|> nctId: NCT06288321 id: UW22221 briefTitle: A Study Investigating Whether Low Dose Eyedrops for Pupil Dilation is as Effective and Safe as Standard Dose Eyedrops in Examination for Retinopathy of Prematurity. overallStatus: COMPLETED date: 2022-08-10 date: 2023-03-22 date: 2023-03-22 date: 2024-03-01 date:... |
Preterm infants were randomized to receive either the standard Mydrin-P eyedrops or the mydriatic microdrops which contained around one-third of the standard Mydrin-P dosage. The primary outcome measured whether a successful ROP examination was conducted. Secondary outcomes included pupil diameters at baselines, 30 min... |
A total of 18 patients were enrolled in this study with total 46 episodes of ROP recorded. All episodes with microdrops instillation led to successful ROP exams. There was no statistically significant difference between standard eyedrops and microdrops in determining the success of ROP exam (p=0.233). Mean pupil diamet... |
Hence the study concluded that microdrops have similar efficacy and safety profile compared to standard Mydrin-P eyedrops. conditions: Retinopathy of Prematurity studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: QUADRUPLE whoMasked: PARTICIP... |
<|newrecord|> nctId: NCT06288308 id: FAR in lupus nephritis (LN) briefTitle: Fibrinogen to Albumin Ratio (FAR) as a Predictive Biomarker for Lupus Nephritis (LN) overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-11 date: 2024-12 date: 2024-03-01 date: 2024-03-01 name: Assiut University class: OTHER briefSum... |
<|newrecord|> nctId: NCT06288295 id: Etude SCORDOM briefTitle: Retrospective Study on Data Aiming to Establish a Prediction Score for Return Home at the Time of Admission to a Multidisciplinary Medical Department (SCORDOM acronym: SCORDOM overallStatus: COMPLETED date: 2021-10-01 date: 2023-02-28 date: 2023-02-28 date:... |
The data collected will be those contained in the medical records of patients over 60 years of age who were admitted to the multidisciplinary medical department between October 2021 and February 2022 and between October 2022 and February 2023. |
This study also aims at developing and validating a predictive score of orientation at the end of hospitalisation. |
Participants are patients previously hospitalized. They will be informed about the study by post and will be able to object to the use of his or her data. conditions: Continuity of Patient Care studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 600 type: ACTUAL measure: Number of ... |
<|newrecord|> nctId: NCT06288282 id: STUDY-23-01287 briefTitle: Behavioral and Cognitive Predictors of Persistent Pain and Opioid Misuse in Chronic Pain overallStatus: RECRUITING date: 2023-12-20 date: 2024-12-20 date: 2024-12-20 date: 2024-03-01 date: 2024-03-01 name: Icahn School of Medicine at Mount Sinai class: OTH... |
<|newrecord|> nctId: NCT06288269 id: PhrapokklaoHospital briefTitle: Factors of Control Hypertension or Type 2 Diabetes on the Severity of Stroke and Survival Rates Within 1 Year in Trat overallStatus: COMPLETED date: 2023-11-01 date: 2023-12-30 date: 2024-01-15 date: 2024-03-01 date: 2024-03-07 name: Phrapokklao Hospi... |
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