text stringlengths 0 197k |
|---|
Researchers will compare the simplified protocol cohort with the standard protocol cohort to determine which one has the best effectiveness, safety, and efficiency indicators in the Venezuela context. |
The effectiveness of the treatment will be measured by the recovery rate, duration of the treatment, and changes in anthropometry (weight, height, and arm circumference). Other treatment effects will also be measured, including how many are admitted to the hospital, death, and relapse rates from the nutritional program... |
<|newrecord|> nctId: NCT06287814 id: RECHMPL23_0299 briefTitle: French Assessment of MRD by Liquid Biopsies in Stage III CRC Patients (FRENCH.MRD.CRC) overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-10-31 date: 2028-10-31 date: 2024-03-01 date: 2024-03-01 name: University Hospital, Montpellier class: OTHE... |
There is a new way to explore if there is any cancer left in a patient's body using circulating tumor DNA (ctDNA) detected in blood samples. This can help decide who needs more treatment after surgery. Even though many tests have been developed, it has yet to be determined which test performs best at relevant time poin... |
The GUIDE.MRD consortium is a group of experts, including scientists, technology, and pharmaceutical companies. The consortium is working on creating a reliable standard for the ctDNA tests, validating their clinical utility, and collecting data to help decide on the best treatment for each patient. |
FRENCH-MRD-CRC is the French study of the european GUIDE.MRD project. conditions: Colorectal Cancer conditions: Stage III Colon Cancer conditions: Minimal Residual Disease conditions: Liquid Biopsy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 70 type: ESTIMATED name: Blood sam... |
<|newrecord|> nctId: NCT06287801 id: 2024P000271 briefTitle: Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 1 acronym: SPIRE1 overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-01-01 date: 2025-06-01 date: 2024-03-01 date: 2024-03-25 name: Massachuse... |
1. Co-design a community-centric implementation strategy for the AWVs vs AWVs + GRACE -augmented care (AWV GRACE) study arms |
2. Develop a referral pathway and algorithm to optimize enrollment of eligible participants |
3. Conduct a pilot clinical trial to assess the feasibility of the AWV GRACE intervention. conditions: Healthy Aging conditions: Health Care Utilization conditions: Health-Related Behavior studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Feasibility o... |
<|newrecord|> nctId: NCT06287788 id: NFEC-2024-068 briefTitle: A Mucosal Contouring Method Based on Swallowing-induced Breakthrough Pain for Radiation-induced Oropharyngeal Mucositis overallStatus: RECRUITING date: 2024-03-01 date: 2026-10-30 date: 2026-12-31 date: 2024-03-01 date: 2024-03-01 name: Nanfang Hospital, So... |
<|newrecord|> nctId: NCT06287775 id: NCI-2024-01398 id: NCI-2024-01398 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 10629 type: OTHER domain: JHU Sidney Kimmel Comprehensive Cancer Center LAO id: 10629 type: OTHER domain: CTEP id: UM1CA186691 type: NIH link: https://reporter.nih.gov/quickSearch/UM... |
<|newrecord|> nctId: NCT06287762 id: 10001737 id: 001737-NR briefTitle: A Natural History Study of RYR1-Related Disorders overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2031-04-30 date: 2031-12-30 date: 2024-03-01 date: 2024-04-26 name: National Institute of Nursing Research (NINR) class: NIH briefSummary: Ba... |
Congenital myopathies (CM) are genetic disorders that can cause decreased muscle tone and muscle weakness. Most CMs in the United States are related to the ryanodine receptor 1 (RYR1) gene. Researchers need more natural history data to learn about these CMs in children and adults. |
Objective: |
To learn more about the signs, symptoms, and course of RYR1-related disorders. |
Eligibility: |
People aged 7 years and older with an RYR1-related disorder. |
Design: |
Ambulatory participants will come to the Clinical Center and non-ambulatory participants will visit via telehealth. |
Visits will be once a year for 3 or 5 years. Clinical Center visits will take 2 to 3 days. |
All participants will undergo tests including: |
Photos and videos. These will be taken to document the participant s condition. |
Blood and urine tests. |
Activity Tracker. Participants will wear a device to record their activity. |
Questionnaires. Participants will answer questions about their health, pain, fatigue, stress, quality of life, and other topics. |
Participants who visit the Clinical Center will also undergo: |
Tests of heart and lung function. |
Motor skills and strength tests. Participants will walk, climb stairs, kneel, crawl, stand up, and perform other movements to test their strength and abilities. They will squeeze and pinch a handheld device to test their grip. |
Imaging scans. |
Skin biopsy. Adult participants may opt to have a sample of skin taken (one time only). |
Eye exam conditions: Ryanodine Receptor 1-Related Myopathy conditions: Ryanodine Receptor 1 Related Disorders studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 150 type: ESTIMATED measure: Adverse and disease-related events measure: Medical data review measure: Ophthalmology measur... |
<|newrecord|> nctId: NCT06287749 id: RECHMPL23_0298 briefTitle: French Assessment of MRD by Liquid Biopsies in PDAC Patients (FRENCH.MRD.PDAC) overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2028-10-31 date: 2028-10-31 date: 2024-03-01 date: 2024-03-01 name: University Hospital, Montpellier class: OTHER briefS... |
Primary objective To confirm that ctDNA analyses performed after PDAC treatment can identify patients with a high risk-of-recurrence. |
Specifically, the investigators want to determine the association between disease-free survival (DFS) and ctDNA detection status after |
1. curative-intended surgery and |
2. adjuvant chemotherapy. |
FRENCH.MRD.PDAC is the French study of the european GUIDE.MRD project conditions: Pancreatic Cancer Resectable conditions: Pancreatic Ductal Adenocarcinoma conditions: Minimal Residual Disease conditions: Liquid Biopsy conditions: ctDNA studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE co... |
<|newrecord|> nctId: NCT06287736 id: 2023H0386 briefTitle: Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-12-31 date: 2026-12-31 date: 2024-03-01 date: 2024-03-01 name: Ohio State University class: OTHER name: Neuright, Inc. briefSummary: This... |
<|newrecord|> nctId: NCT06287723 id: RECHMPL23_0297 briefTitle: French Assessment of MRD by Liquid Biopsies in Colorectal With Liver Metastasis Patients (FRENCH.MRD.CRLM) overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-10-31 date: 2028-10-31 date: 2024-03-01 date: 2024-03-01 name: University Hospital, Mon... |
There is a new way to explore if there is any cancer left in a patient's body using circulating tumor DNA (ctDNA) detected in blood samples. This can help decide who needs more treatment after surgery. Even though many tests have been developed, it has yet to be determined which test performs best at relevant time poin... |
The GUIDE.MRD consortium is a group of experts, including scientists, technology, and pharmaceutical companies. The consortium is working on creating a reliable standard for the ctDNA tests, validating their clinical utility, and collecting data to help decide on the best treatment for each patient. |
FRENCH.MRD.CRLM is the French study and part of the european GUIDE.MRD project. conditions: Colorectal Cancer conditions: Liver Metastases conditions: Stage IV Colorectal Cancer conditions: Minimal Residual Disease conditions: Liquid Biopsy conditions: ctDNA studyType: OBSERVATIONAL observationalModel: COHORT timePersp... |
<|newrecord|> nctId: NCT06287710 id: CHUBX 2023/32 briefTitle: Fluid Responsiveness Evaluation by a Non-invasive Method in Children, Extended to PREterm Infants - FRENCH-PREMA acronym: FRENCH-PREMA overallStatus: RECRUITING date: 2024-01-17 date: 2024-11-17 date: 2025-04-17 date: 2024-03-01 date: 2024-03-01 name: Unive... |
<|newrecord|> nctId: NCT06287697 id: LOA/RAP/2019/20 briefTitle: Energy Expenditure and Body Composition of Infants and Young Children (6-24 Months Old) in Asia overallStatus: ACTIVE_NOT_RECRUITING date: 2020-01-21 date: 2024-11-30 date: 2024-11-30 date: 2024-03-01 date: 2024-03-01 name: Mahidol University class: OTHER... |
<|newrecord|> nctId: NCT06287684 id: ESICM-22 briefTitle: Molecular Endotype-Specific Dynamics of Lung Endothelial Barrier Integrity in Sepsis acronym: MENDSEP overallStatus: RECRUITING date: 2023-09-13 date: 2025-12-30 date: 2025-12-30 date: 2024-03-01 date: 2024-03-01 name: Mater Dei Hospital, Malta class: OTHER name... |
<|newrecord|> nctId: NCT06287671 id: COCO briefTitle: Colorectal Omics and ofCS Proteoglycans acronym: COCO overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-12 date: 2032-12 date: 2024-03-01 date: 2024-03-01 name: Claus Anders Bertelsen, PhD, MD class: OTHER name: Viborg Regional Hospital briefSummary: This o... |
The main questions to answer are: |
* can these biomarkers predict anastomotic leakages |
* can these biomarkers predict recurrence after colorectal cancer |
* can these biomarkers be used as diagnostic tests for colorectal cancer |
* can these biomarkers be identified in the tumor |
Participants will undergo elective colorectal resection or stoma closure. conditions: Colorectal Cancer conditions: Diverticulitis, Colonic conditions: Inflammatory Bowel Diseases conditions: Stoma Colostomy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED nam... |
<|newrecord|> nctId: NCT06287658 id: E-57428665-050.04-240046 briefTitle: The Effect of Kegel Exercise and Ba Duan Jin Applications on Premenopausal Women With Urinary Incontinence overallStatus: RECRUITING date: 2024-04-01 date: 2024-07-01 date: 2025-03-01 date: 2024-03-01 date: 2024-04-03 name: Ondokuz Mayıs Universi... |
<|newrecord|> nctId: NCT06287645 id: Retinal Images Dataset briefTitle: Color Fundus Photograph With Experts Labelling overallStatus: RECRUITING date: 2022-05-12 date: 2025-12-31 date: 2026-06-30 date: 2024-03-01 date: 2024-03-07 name: Pakistan Council of Scientific and Industrial Research class: OTHER name: Al-Ibrahim... |
<|newrecord|> nctId: NCT06287632 id: 2024P000451 briefTitle: CPAP in Patients With Severe Obesity After Anesthesia overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-11 date: 2026-06 date: 2024-03-01 date: 2024-03-01 name: Massachusetts General Hospital class: OTHER briefSummary: The goal of this study is to co... |
1. Does a recruitment maneuver and CPAP set to intrathoracic pressure (ITP) improve cardiopulmonary function compared to standard CPAP settings in patients with severe obesity after anesthesia? |
2. Does the location of adipose tissue influence the response to CPAP settings in patients with severe obesity after anesthesia? |
Participants will undergo monitoring of their intrathoracic pressure using an esophageal catheter. In the recovery area after anesthesia, participants will receive two CPAP settings, each for 20 minutes. |
* Intervention 1: Recruitment maneuver and CPAP will set to the level of intrathoracic pressure |
* Intervention 2: CPAP set to home settings (if OSA is present) or between 8-10 cmH20 (if OSA is not present). conditions: Obesity, Abdominal conditions: Anesthesia Morbidity conditions: Apnea, Obstructive Sleep conditions: Atelectases, Postoperative Pulmonary conditions: Ventilator Lung studyType: INTERVENTIONAL phase... |
<|newrecord|> nctId: NCT06287619 id: 22-5685 briefTitle: Post-operative Intravenous Iron to Treat Iron-deficiency Anemia in Patients Undergoing Cardiac Surgery acronym: POAM overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2025-06 date: 2024-03-01 date: 2024-03-07 name: University Health Network, Tor... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.