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The brain and spinal cord are enveloped by cerebrospinal fluid (CSF), which extends down to the base of the spine, a few centimeters below the termination of the spinal cord. Here, it can be collected through a minor needle puncture. This procedure enables the gathering of information about otherwise concealed molecula... |
OBJECTIVE |
Sub-study 1 aims to collect CSF from individuals with AUD across various ages to analyze brain molecules that contribute to the development and maintenance of the disease. |
Sub-study 2 aims to gather CSF from healthy controls across various ages to study molecules involved in neurological and psychiatric conditions, including AUD, substance dependency, brain inflammation, and narcolepsy. The goal is to create a reference group of CSF from healthy controls for comparison with CSF collected... |
We hypothesize that levels of certain molecules, such as dopamine, differ between healthy controls and those with e.g. AUD. This study may provide insights into cellular and molecular mechanisms underlying brain disorders, which is in turn crucial for developing new, effective treatments. |
Sub-study 3 will examine how the incubation of nerve cells in CSF collected in sub-study 1 and 2 affects their excitability and ability to form new synapses, essential for communication in the brain. |
We hypothesize that the excitability and synaptogenesis of nerve cells will vary depending on whether they are incubated in CSF from neurologically and psychiatrically healthy individuals versus those with AUD, substance use disorders, brain inflammation, and narcolepsy. Understanding how CSF composition influences bra... |
METHODS |
Individuals with AUD, as well as psychiatrically and neurologically healthy volunteers, will be successively recruited for CSF collection and analyses. Recruitment will be performed through media advertisements and posters within healthcare facilities (The Sahlgrenska University Hospital) and the University of Gothenbu... |
SIGNIFICANCE |
CSF studies offers unique insights into the cellular and molecular processes within the brain. This approach has been utilized for exploring the mechanisms behind several psychiatric and neurological disorders, but not for certain brain diseases like AUD. AUD inflicts significant suffering for affected individuals, con... |
<|newrecord|> nctId: NCT06286436 id: IR.SBMU.RETECH.REC.1401.842 briefTitle: Effect of Dual-task Training on the Number of EEG Band in Stroke Patients overallStatus: NOT_YET_RECRUITING date: 2024-02-25 date: 2024-04-29 date: 2024-05-29 date: 2024-02-29 date: 2024-03-01 name: Universidad de Zaragoza class: OTHER briefSu... |
The study suggests using electroencephalogram (EEG) analysis, particularly the Fast Fourier Transform (FFT), to assess changes in brain signals pre- and post-DTT intervention. EEG provides real-time insights into brain function, and FFT analyzes signal frequencies. The intervention involves three tasks performed concur... |
<|newrecord|> nctId: NCT06286423 id: HSR220446 briefTitle: Colchicine in Acutely Decompensated HFREF overallStatus: RECRUITING date: 2024-03 date: 2026-02 date: 2028-02 date: 2024-02-29 date: 2024-03-20 name: University of Virginia class: OTHER briefSummary: This is a double blind, placebo-controlled pilot trial random... |
Upon enrollment, patients will be randomized 1:1 to receive either the experimental drug (Colchicine) or matching placebo. The regimen in the active arm will consist of 14 days of Colchicine 0.6 mg bid followed by 76±14 days of Colchicine 0.6 mg once per day. Placebo regimen will be analogous, with one pill bid for 14 ... |
These patients will continue with their standard of care for the management of heart failure which consists of a combination of medications that relieve congestion, normalize blood pressure and heart rate, and block the effects of hormones on the heart. The proposed treatment will be in addition to standard of care. No... |
Blood will be obtained from the patients in order to measure hsCRP and IL-6. Blood samples will be collected at baseline, 24±6h, 48±6h and 72±6h after treatment initiation, and subsequently at 14±7 days and at study closure. The first four blood samples will be obtained while the subject is still admitted to the hospit... |
<|newrecord|> nctId: NCT06286410 id: 184950 briefTitle: Accommodation Response in Hypermetropic Anisometropia (ARIHA Study) acronym: ARIHA overallStatus: NOT_YET_RECRUITING date: 2024-02 date: 2024-12 date: 2024-12 date: 2024-02-29 date: 2024-03-01 name: University of Sheffield class: OTHER name: Sheffield Children's N... |
With standard care treatment (glasses plus either patching or atropine drops given to the better seeing eye), 35% of children with anisometropic amblyopia do not have any significant visual improvements, and will have reduced vision in one eye for life. There is no consensus for the reasons why some children do not res... |
Recent research using the Plusoptix PowerRefractor (PR3), which quickly measures eye focusing (accommodation), suggested that in children with anisometropic amblyopia, the focusing of the amblyopic eye might influence treatment success. However, such measurements weren't previously common due to equipment limitations i... |
The investigators aim to use the non-invasive PR3 to assess accommodation in hypermetropic anisometropic amblyopia, at the University of Sheffield. This will be a two-phase study of children aged 4-10 years who have hypermetropic anisometropia. The investigators will recruit participants attending the Ophthalmology Dep... |
The participants found to have residual amblyopia following standard care treatment (completed treatment but still have unequal vision) and asymmetrical accommodation (following their PR3 measurements and data interpretation), will be offered an intervention dependent upon their type of asymmetrical accommodation. Ther... |
Asymmetrical accommodation can be one of two things: Aniso-A and Anti-A. primaryPurpose: TREATMENT masking: NONE count: 22 type: ESTIMATED name: Bespoke glasses prescription worn during amblyopia treatment. measure: Change in visual acuity measure: Change in PR3 accommodation measurements sex: ALL minimumAge: 4 Years m... |
<|newrecord|> nctId: NCT06286397 id: 855173 briefTitle: Topical Anti-Androgens in Pilonidal Sinus Disease overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-05-01 date: 2027-12-01 date: 2024-02-29 date: 2024-03-04 name: University of Pennsylvania class: OTHER briefSummary: The goal of this randomized clinica... |
* Does clascoterone improve the severity of pilonidal disease as scored by a physician? |
* Does clascoterone improve patient symptoms due to pilonidal disease? |
* Does clascoterone improve the inflammation seen under the microscope in pilonidal disease removed at surgery Participants will apply clascoterone or a placebo cream to the diseased area for 3 months. They will be assessed every 4 weeks for disease severity assessed by a physician viewing patient photos and a symptom-... |
Researchers will compare participants who received clascoterone treatment to those who received placebo. conditions: Pilonidal Disease conditions: Pilonidal Disease of Natal Cleft conditions: Pilonidal Sinus conditions: Pilonidal Cyst studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PA... |
<|newrecord|> nctId: NCT06286384 id: LEMU47 briefTitle: Evaluating the Long-term Effects of Microfocused Ultrasound on Facial Tightening Using Quantitative Instruments overallStatus: RECRUITING date: 2023-07-03 date: 2024-09-15 date: 2025-03-15 date: 2024-02-29 date: 2024-02-29 name: First Affiliated Hospital of Jinan ... |
<|newrecord|> nctId: NCT06286371 id: 2023-13/37 briefTitle: Pelvic Neuro-Angiogenesis in Deep Endometriosis overallStatus: RECRUITING date: 2023-12-01 date: 2024-09 date: 2025-04 date: 2024-02-29 date: 2024-03-04 name: Uludag University class: OTHER briefSummary: Endometriosis is observed in one out of every ten women ... |
Nodular formations in the pelvic region due to endometriosis are especially observed in the rectovaginal space. Despite being small in size, they can induce increased neovascularization and neurogenesis even in healthy peritoneal tissue due to the microenvironment they create, leading to different clinical symptoms cli... |
In this project, in patients operated on due to endometriosis, the density of nerve and vascular structures in the surgical margins of the peritoneal tissue excised along with the nodule, and the synthesis and release of chemical mediators causing pain (e.g., Bradykinin, Substance-P) are evaluated. The aim is to determ... |
<|newrecord|> nctId: NCT06286358 id: P2023/346 / CCB : B40620230001 briefTitle: Aortopathy Relationship To Imagery and Kinocardiography Features (ARTIK) acronym: ARTIK overallStatus: RECRUITING date: 2024-03-07 date: 2025-03-30 date: 2025-09-30 date: 2024-02-29 date: 2024-03-12 name: Université Libre de Bruxelles class... |
The goal of this observational study is to learn about kinocardiography in patients with aortic valve disease (AVD) or thoracic aortic aneurysm (TAA). The investigators believe that this technology will enable us to diagnose aortic valve disease and aortic aneurysm. |
In patients with AVD of different severities or TAA, the investigators will collect informations from echocardiography and/or cardiac magnetic resonance imaging and KCG recordings. Researchers will also compare subjects without any AVD nor TAA to better understand these effects on KCG. conditions: Aortic Valve Disease ... |
<|newrecord|> nctId: NCT06286345 id: 17644 briefTitle: Lifestyle InterVEntion Study in General Practice: LIVES - GP acronym: LIVES-GP overallStatus: RECRUITING date: 2023-08-01 date: 2025-03-01 date: 2025-07-01 date: 2024-02-29 date: 2024-03-04 name: University Medical Center Groningen class: OTHER name: GGZ Drenthe Me... |
<|newrecord|> nctId: NCT06286332 id: Interventional briefTitle: Music Therapy in Acute Leukemia Patients With Fatigue overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2026-03-01 date: 2024-02-29 date: 2024-03-06 name: Chang Gung University class: OTHER briefSummary: The objective of this study ... |
<|newrecord|> nctId: NCT06286319 id: 23-00726 briefTitle: Cold Oxygen Lung Preservation and Ventilation With the "Angel Cooler" overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-04 date: 2024-02-29 date: 2024-02-29 name: NYU Langone Health class: OTHER briefSummary: The objective of this feasibil... |
<|newrecord|> nctId: NCT06286306 id: 2022_0232 id: 2022-A02813-40 type: OTHER domain: ID-RCB number, ANSM briefTitle: Pronostic Value of Fluid Responsiveness Evaluated by Inferior Vena Cava Collapsibility Index in Patients Admitted in ICU With Acute Respiratory Failure acronym: PRIVACY overallStatus: RECRUITING date: 2... |
This practice is grounded in the concept of " preload responsiveness ". However, the accrual of positive fluid balance resulting from fluid administration is now acknowledged as an autonomous risk factor for mortality. |
Consequently, preload unresponsiveness assumes a pathological character, potentially indicative of fluid overload or right ventricular dysfunction, both deleterious conditions linked to unfavorable outcomes. |
Maintaining patients in a preload-responsive state may be interesting to limit fluid expansion and the need of invasive mechanical ventilation. |
The objective of this prospective observational study is to evaluate the prognostic significance of preload responsiveness in patients admitted to the ICU with hypoxemic, non-hypercapnic respiratory failure. |
* Main objective: To evaluate the association between fluid responsiveness, assessed by the inferior vena cava collapsibility index (cIVC) with trans-thoracic echocardiography within the initial 48 hours post-ICU admission, and mortality or the need for invasive mechanical ventilation by day 28 in patients admitted to ... |
* Secondary objectives: To evaluate the association between fluid responsiveness and mortality at day 28 and day 90, the need of invasive mechanical ventilation, and the number of days free from organ support (vasopressors, mechanical ventilation and renal replacement therapy) by day 28. |
Upon receipt of both oral and written information, patients will provide non-objection to participate in the study. This prospective single-center study has obtained approval from the Regional Ethics Committee of Ile de France III approval (No. 2022-A02813-40). conditions: Hypoxemic Without Hypercapnia Acute Respirator... |
<|newrecord|> nctId: NCT06286293 id: 18171 briefTitle: YOD-RiSoCo: Social Cognition and Risky Decision-making in Patients With Young-onset Dementia acronym: YOD-RiSoCo overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-06-30 date: 2027-03-31 date: 2024-02-29 date: 2024-03-04 name: University Medical Center G... |
* Examine differences in performance on social cognition test and measures of risky behaviour between behavioural variant YOD patients, patients with frontal brain injury, non-behavioural YOD patients and healthy controls. |
* Examine if there is a relation between social cognition tests and measures of risky behaviour. |
Participants will be administered a neuropsychological assessment including social cognition measures and patients will complete a driving simulator task in which risky behaviour will be elicited. conditions: Young-onset Dementia studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: CROSS_SECTIONAL... |
<|newrecord|> nctId: NCT06286280 id: AZ221/21 id: F/23/22 type: OTHER_GRANT domain: German Foundation of Heart Research briefTitle: Removal Of CytoKines With cytoSorbenTs After Inflammatory Response Reaction During Cardiac Surgery acronym: ROCKSTAR overallStatus: RECRUITING date: 2023-05-01 date: 2024-12-01 date: 2025-... |
This pilot study aims to clarify the relationship between CD34-positive EPCs and cytokine release during ECC using the cytokine adsorber to make a predictive statement regarding the clinical expression of inflammation. conditions: Inflammatory Response studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interve... |
<|newrecord|> nctId: NCT06286267 id: SYSKY-2023-351-02 briefTitle: AI-Assisted System for Accurate Diagnosis and Prognosis of Breast Phyllodes Tumors overallStatus: RECRUITING date: 2023-03-01 date: 2027-12-31 date: 2027-12-31 date: 2024-02-29 date: 2024-02-29 name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen Universi... |
In recent years, there has been growing interest in the application of artificial intelligence (AI) in medical diagnostics. AI can integrate clinical information, histopathological images, and multi-omics data to assist in pathological and clinical diagnosis, prognosis prediction, and molecular profiling.AI has shown p... |
The research team, led by Dr. Nie Yan, is one of the few in Guangdong Province and even nationally, specializing in PT research. Their team has been conducting research on the malignant progression, metastasis mechanisms, and molecular markers for PT. The team has identified key mechanisms, such as fibroblast-to-myofib... |
The project has collected high-quality data from nearly a thousand breast PT patients, including imaging, histopathology, and survival data, and has performed transcriptome gene sequencing on tissue samples. They aim to build a comprehensive multi-omics database for breast PT and create an AI-based model for early diag... |
<|newrecord|> nctId: NCT06286254 id: CYCL-NTTF-2023 briefTitle: Study of Safety and Efficacy of the Drug Cycloferone in Patients With Acute Respiratory Viral Infection overallStatus: ACTIVE_NOT_RECRUITING date: 2023-09-20 date: 2024-02-20 date: 2024-07-30 date: 2024-02-29 date: 2024-02-29 name: POLYSAN Scientific & Tec... |
<|newrecord|> nctId: NCT06286241 id: 877/2564(IRB2) briefTitle: Comparison of the Complications in Multiple Myeloma Patients Who Received Autologous Stem Cell Transplantation Between in HEPA-filtered Room and Non-HEPA-filtered Room acronym: Step down ward overallStatus: NOT_YET_RECRUITING date: 2024-03-25 date: 2024-06... |
* The incidence of febrile neutropenia, infection, and duration of hospital stay |
* 2-year progression free survival Participants will be collected the data of baseline diagnosis, treatment, treatment results and complications during admission and follow-up visits from hospital medical record. conditions: Multiple Myeloma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER cou... |
<|newrecord|> nctId: NCT06286228 id: 751/2563(IRB4) briefTitle: Registry of Haploidentical Hematopoietic Stem Cell Transplantation in Adult With Hematologic Disease acronym: Haplo overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2029-04-01 date: 2030-04-01 date: 2024-02-29 date: 2024-03-01 name: Siriraj Hospita... |
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