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* 1-year progression free survival rate |
* 1-year overall survival rate |
* Graft-versus-host free relapsed free survival at 30-day, 100-day, 180-day and 1-year |
* Chronic Graft-versus-host free relapsed free survival at 180-day and 1-year |
* Rate of Neutrophil and platelet engraftment |
* Efficacy of donor specific antibody desensitization |
* Relapsed rate |
* Primary and late graft failure |
* Safety and complication of haploHSCT |
* Complication of viral, bacterial, and fungal infection |
* Viral reactivation |
* Comparison outcomes between matched sibling donor (MSD) HSCT and matched unrelated donor (MUD) HSCT |
* Comparison cost-effectiveness of treatment between matched sibling donor (MSD) HSCT and matched unrelated donor (MUD) HSCT Participants will be collected the data of baseline diagnosis, treatment, treatment results of all admission and follow-up visits from hospital medical record. conditions: Multiple Myeloma studyT... |
<|newrecord|> nctId: NCT06286215 id: 586/2564(IRB2) briefTitle: Registry of Patients With Plasma Cell Disorders acronym: Registry PCD overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2034-04-01 date: 2035-04-01 date: 2024-02-29 date: 2024-02-29 name: Siriraj Hospital class: OTHER name: Faculty of Medicine Sirir... |
* The incidence of plasma cell disorders both before and after malignancy |
* Time to progression of monoclonal gammopathy of undetermined significant (MGUS) or smoldering multiple myeloma (SMM) to light chain amyloidosis or multiple myeloma (MM) |
* Progression free survival (PFS) |
* overall survival |
* factors influencing overall survival, progression-free survival, and time to progression |
* Symptoms and signs of the disease during the diagnosis and relapse phases, including the causes of mortality in plasma cell disorder patients. |
* genetic characteristics of plasma cell disorder |
* cost-effectiveness of treatment in Thailand Participants will be collected the data of baseline diagnosis, treatment, treatment results of all admission and follow-up visits from hospital medical record. conditions: Plasma Cell Disorders studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE... |
<|newrecord|> nctId: NCT06286202 id: RECAS-0306 briefTitle: Integrative Neuro-social Cognitive Strategy Programme for Instilling REcovery (INSPIRE) a Community-Based Cognitive Remediation Trial overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-12 date: 2027-07 date: 2024-02-29 date: 2024-03-04 name: Singapore ... |
Therefore, the aims of the study are: |
* To investigate the effects of cognitive remediation on various cognitive skills (such as attention, memory, problem-solving, facial expression recognition, taking others' perspectives etc), for participants with schizophrenia or schizoaffective disorders in community mental health settings. |
* To investigate if factors such as participants' motivation for engagement and social interaction can affect changes in cognitive skills and functional ability. |
Participants in the treatment group will attend computer-based cognitive exercises to improve their cognitive skills. They will also participate in group sessions facilitated by therapists to learn how to utilize strategies learned from the computer sessions in their daily lives. Participants in the control group will ... |
This research study will compare the differences in their cognitive performance, functional ability and recovery immediately after the intervention and 8 weeks later. conditions: Schizophrenia conditions: Schizoaffective Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL in... |
<|newrecord|> nctId: NCT06286189 id: 2020P002760-t briefTitle: Trazodone on OSA Endotypes overallStatus: RECRUITING date: 2024-01-01 date: 2025-01-01 date: 2025-06-01 date: 2024-02-29 date: 2024-02-29 name: Brigham and Women's Hospital class: OTHER briefSummary: Obstructive sleep apnea (OSA) is common and has major hea... |
<|newrecord|> nctId: NCT06286176 id: LIUIRB-200311-NR1 briefTitle: Breastfeeding Promotion in Lebanon Through a Salutogenic Intervention overallStatus: COMPLETED date: 2022-11-17 date: 2023-06-30 date: 2023-06-30 date: 2024-02-29 date: 2024-02-29 name: Nabiha Ramadan class: OTHER name: Universitat de Girona briefSummar... |
<|newrecord|> nctId: NCT06286163 id: PA4099 briefTitle: Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients overallStatus: RECRUITING date: 2023-10-01 date: 2024-12-31 date: 2025-06-30 date: 2024-02-29 date: 2024-02-29 name: Imperial College London class: OTHER name: Merck S... |
In this study, the research team will examine 10 participants who suffer from chronic cough and 8 individuals who do not have a chronic cough and are healthy. conditions: Chronic Cough studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 18 type: ESTIMATED measure: Presence of ATP in ... |
<|newrecord|> nctId: NCT06286150 id: EC-2023-087(QX)-03 briefTitle: Efficacy and Safety of Single-port Surgical Robot System in Thoraic Surgery overallStatus: RECRUITING date: 2023-09-15 date: 2025-07-15 date: 2027-07-15 date: 2024-02-29 date: 2024-02-29 name: The First Affiliated Hospital of Guangzhou Medical Universi... |
<|newrecord|> nctId: NCT06286137 id: NL82922.078.22 briefTitle: Duration of Music Interventions and Pain Tolerance (DOMINANT) acronym: DOMINANT overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-02 date: 2025-06 date: 2024-02-29 date: 2024-03-06 name: Erasmus Medical Center class: OTHER briefSummary: This study... |
<|newrecord|> nctId: NCT06286124 id: 8612 briefTitle: Midline Restoration After HYbriD Hernia RepAir Surgery (HYDRA) acronym: HYDRA overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2028-04 date: 2024-02-29 date: 2024-02-29 name: Erasmus Medical Center class: OTHER name: Medtronic name: Alrijne Hospit... |
<|newrecord|> nctId: NCT06286111 id: ASU MD briefTitle: Red Cell Distribution Width as a Predictor for Post Operative Atrial Fibrillation After Open Heart Surgries overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-06-01 date: 2024-08-01 date: 2024-02-29 date: 2024-04-23 name: Ain Shams University class: OTH... |
<|newrecord|> nctId: NCT06286098 id: ALA in Pediatrics on HD briefTitle: Alpha Lipoic Acid in Pediatrics on Hemodialysis overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-09-20 date: 2024-10-20 date: 2024-02-29 date: 2024-03-12 name: Ain Shams University class: OTHER name: Eva Pharma briefSummary: The goal ... |
* Will the use of alpha lipoic acid lower cardiovascular events in that population? |
* Is the incidence of those cardiovascular events linked to the oxidative stress and endothelial dysfunction in that population? |
* Will the drug cause side effects? |
Participants will: |
* take either one dose daily of 600mg tablet Alpha lipoic acid orally or a look-alike tablet containing no drug. |
* be monitored for the occurrence of cardiovascular events (stroke, angina, etc.) |
* be monitored for the occurrence of side effects |
* give blood samples for testing serum levels of E-selectin biomarker and superoxide dismutase enzyme |
* undergo clinical examinations (Echocardiogram, Duplex ultrasonography, Intima-Media-Thickness) Researchers will compare between the group taking alpha lipoic acid and the group taking the look-alike tablet. conditions: Hemodialysis Complication conditions: Pediatric Kidney Disease conditions: Cardiovascular Complicat... |
<|newrecord|> nctId: NCT06286085 id: 337788 briefTitle: A Comparison of Diagnostic Testing Modalities in the Assessment of Asthma acronym: MODELS overallStatus: RECRUITING date: 2024-02-27 date: 2024-04-24 date: 2024-07-24 date: 2024-02-29 date: 2024-04-04 name: Portsmouth Hospitals NHS Trust class: OTHER_GOV briefSumm... |
<|newrecord|> nctId: NCT06286072 id: YCEYHANS briefTitle: The Effect of Education and Reminder Messages on the Fatigue Level of Individuals With COPD overallStatus: RECRUITING date: 2023-11-01 date: 2024-01-30 date: 2024-03-30 date: 2024-02-29 date: 2024-02-29 name: Kirsehir Ahi Evran Universitesi class: OTHER briefSum... |
The main questions it aims to answer are: |
1. Does the training given in COPD affect the level of fatigue? |
2. Do the education given and text messages sent regarding COPD affect the level of fatigue? |
In this study, patients were given informative education about COPD and ways to cope with fatigue were explained. Then, in order to increase the permanence of the training, motivational messages and short briefings were continued for 8 weeks.2 messages were sent per week. Three groups were created to reveal the effecti... |
Group 1 was trained and messages were sent for 8 weeks. Group 2 was trained and no message was sent. Group 3 is the control group. No training has been provided other than routine maintenance. |
The initial information of all groups was taken again at the end of the 8th week. |
Main outcomes: |
* Dyspnea severity, |
* COPD general conditions and |
* Fatigue level. The results obtained will be interpreted by comparing between 3 groups. conditions: Copd conditions: Fatigue studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomised Controlled Trial primaryPurpose: SUPPORTIVE_CARE masking: SINGLE ... |
<|newrecord|> nctId: NCT06286059 id: Phentolamine for CA-AKI briefTitle: Efficacy of Phentolamine in Prevention of Contrast-Associated Acute Kidney Injury After Complex PCI overallStatus: RECRUITING date: 2024-03-07 date: 2024-12-31 date: 2025-01-31 date: 2024-02-29 date: 2024-03-18 name: Helwan University class: OTHER... |
<|newrecord|> nctId: NCT06286046 id: AG348-C-026 id: 2023-510289-28-00 type: OTHER domain: EU Clinical Trial Number briefTitle: A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-05 date: 2027-09 date: 2024-02-29 date: 2024-04-12 name... |
<|newrecord|> nctId: NCT06286033 id: AG181-C-001 briefTitle: A Safety Study of Single and Multiple Doses of AG-181 in Healthy Participants overallStatus: RECRUITING date: 2024-02-20 date: 2025-06-01 date: 2025-06-01 date: 2024-02-29 date: 2024-04-16 name: Agios Pharmaceuticals, Inc. class: INDUSTRY briefSummary: The pr... |
<|newrecord|> nctId: NCT06286020 id: VR-Zhenqiu briefTitle: Effect of Virtual Reality Therapy on Dysphagia in Wallenberg Syndrome overallStatus: RECRUITING date: 2024-02-28 date: 2024-07 date: 2024-07 date: 2024-02-29 date: 2024-03-06 name: Zeng Changhao class: OTHER briefSummary: The goal of this clinical trial is to ... |
the efficacy of Virtual Reality Therapy in the rehabilitation of patients with dysphagia in Wallenberg syndrome. |
Participants received conventional dysphagia treatment and Virtual Reality Therapy once a day for 14 days. Researchers compared the control group to see the effect and mechanism of Virtual Reality Therapy. conditions: Wallenberg Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PAR... |
<|newrecord|> nctId: NCT06286007 id: PRIPASCO-2023 briefTitle: Prevalence and Impact of Pertussis and RSV on Asthma Severity and Control acronym: PRIPASCO overallStatus: RECRUITING date: 2023-12-21 date: 2024-07-31 date: 2026-07-01 date: 2024-02-29 date: 2024-03-01 name: Hospital Clinico Universitario de Santiago class... |
A multicentre prospective cohort study will be undertaken in Spain. Thirty-five centres from different autonomous communities in Spain will participate in the study. |
Participants will be asked to report to the investigator if they experience an asthma exacerbation or symptoms of acute respiratory infection with 2 years follow up conditions: Asthma conditions: Pertussis conditions: RSV Infection studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: ... |
<|newrecord|> nctId: NCT06285994 id: SRB2024016 briefTitle: Complications of High Frequency Jet Ventilation overallStatus: RECRUITING date: 2024-04-20 date: 2024-08-31 date: 2024-10-31 date: 2024-02-29 date: 2024-04-24 name: Erasme University Hospital class: OTHER briefSummary: High frequency jet ventilation (HFJV) has... |
* Hypoxia: SpO2 \< 90% for 1 min |
* Severe hypoxia: SpO2 \< 85% for 1 min |
* Hemodynamic instability, defined as Arterial pressure \< 90/60 |
* Cardiac arrhythmia |
* Laryngospasm or bronchospasm |
* Barotrauma or volutrauma |
* Need for ICU admission |
A model predicting the risk for developing any complication will be developped using 2 mathematical methods: |
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