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The aim of this prospective monocentric and observational study is to identify predictive biomarkers and/or risk factors for PF or PPAP using metabolomics. The Profiling of circulating metabolites is indeed an original and promising approach for this purpose. We will also investigate the patient's immune status and its... |
Participants will be adult patients scheduled to undergo elective pancreaticoduodenectomy. Surgery and patient's management will be as usual. During surgery, a fragment (0.1-0.2 g) of non-tumoral pancreatic tissue will be removed and frozen at -80°C for metabolomic analysis. For immunological assessment, 4 blood sample... |
<|newrecord|> nctId: NCT06283147 id: 2023.530 briefTitle: Risk Assessment and Management Program (RAMP) on Knee Osteoarthritis in Primary Care overallStatus: RECRUITING date: 2024-04-01 date: 2025-11-30 date: 2026-04-01 date: 2024-02-28 date: 2024-03-22 name: Chinese University of Hong Kong class: OTHER briefSummary: T... |
Participants will be screened for eligibility to participate. After confirming eligibility, participants will complete the baseline assessment and be randomized into one of the following groups (n=114 for each group): |
1. RAMP Knee-OA group |
2. Usual care group |
Outcomes will be measured at baseline, week 16, week 32, and week 52. conditions: Knee Osteoarthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The study is a 52-week, two-arm, parallel, doubled-blinded randomized clinical trial, evaluating the... |
<|newrecord|> nctId: NCT06283134 id: BJCT-CMU1H-02 briefTitle: A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-02 date: 2027-12-01 date: 2027-12-01 date: 2024-02-28 date: 2024-02-29 name: China Medical Unive... |
<|newrecord|> nctId: NCT06283121 id: BJCT-CMU1H-01 briefTitle: A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-02 date: 2027-11-30 date: 2027-11-30 date: 2024-02-28 date: 2024-02-29 name: China Medical University, Chin... |
<|newrecord|> nctId: NCT06283108 id: 23-1183 briefTitle: Gurney Journey: Virtual Reality Distraction overallStatus: RECRUITING date: 2024-03-01 date: 2024-06 date: 2024-06 date: 2024-02-28 date: 2024-03-08 name: Children's Hospital Colorado class: OTHER briefSummary: The aim of this study is to determine whether a soft... |
<|newrecord|> nctId: NCT06283095 id: OSA briefTitle: Management of Obstructive Sleep Apnea Syndrome by Expansion Palatoplasty overallStatus: RECRUITING date: 2023-11-01 date: 2025-11-01 date: 2026-11-01 date: 2024-02-28 date: 2024-02-28 name: ET Zarief class: OTHER briefSummary: The study will be conducted to evaluate ... |
<|newrecord|> nctId: NCT06283082 id: 69HCL23_0617 id: ID-RCB type: OTHER domain: 2023-A01406-39 briefTitle: Oxalate Excretion Profile in Patients With a Heterozygous Mutation of the AGXT (Alanine-glyoxylate Aminotransferase) Gene acronym: HETEROX overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-... |
Non-genetic etiologies of oxalic nephropathy are well known, in particular enteric causes (malabsorptions, bypass, calcium deficiencies, etc.) and sometimes linked to increased oxalate intake in the form of nutritional or vitamin supplements, reinforcing the hypothesis of probably underestimated favouring factors of hy... |
Until now, heterozygous patients with a mutation in the AGXT gene were considered asymptomatic. However, there have been several cases of patients with heterozygous AGXT mutations presenting with lithiasis. |
Consequently, the characteristics of symptomatic and asymptomatic heterozygous patients will be studied in order to define the elements that would explain the expression of the disease (particularities of the AGXT mutation, presence of another heterozygous mutation or favorable living conditions). |
The hypothesis is that there is an increase in hepatic oxalate production in heterozygous patients, which explains why they remain asymptomatic under usual conditions, but could favor stone formation under favorable conditions such as severe calcium deficiency or malabsorption. conditions: Hyperoxaluria (Disorder) stud... |
<|newrecord|> nctId: NCT06283069 id: 45C301 briefTitle: Relationship Between Lifestyle Indicators and Cardiovascular Clinical Parameters acronym: RICH overallStatus: RECRUITING date: 2023-05-01 date: 2024-12-31 date: 2033-04-30 date: 2024-02-28 date: 2024-02-28 name: Istituto Auxologico Italiano class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06283056 id: DO611073A briefTitle: RF Microneedling With Multi-Depth Targeting Per Insertion for The Treatment of Cellulite overallStatus: RECRUITING date: 2022-06-16 date: 2024-06-01 date: 2025-06-01 date: 2024-02-28 date: 2024-02-28 name: InMode MD Ltd. class: INDUSTRY briefSummary: The aim of... |
<|newrecord|> nctId: NCT06283043 id: 2022/3749 briefTitle: Effect of Motor Function, Depression and Sleep Quality on Attention in Parkinson's Disease overallStatus: ENROLLING_BY_INVITATION date: 2024-01-01 date: 2024-03-01 date: 2024-03-05 date: 2024-02-28 date: 2024-02-28 name: Inonu University class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06283030 id: IM-001 briefTitle: Evaluation of Hypoglossal Nerve Stimulation in Humans With Obstructive Sleep Apnea overallStatus: COMPLETED date: 2021-12-01 date: 2023-09-25 date: 2023-09-25 date: 2024-02-28 date: 2024-03-07 name: Invicta Medical Inc. class: INDUSTRY name: Vanderbilt University ... |
<|newrecord|> nctId: NCT06283017 id: IM-002 briefTitle: Evaluation of the Effects of Hypoglossal Nerve Stimulation in Humans With Obstructive Sleep Apnea overallStatus: ACTIVE_NOT_RECRUITING date: 2022-06-01 date: 2024-03 date: 2024-03 date: 2024-02-28 date: 2024-03-13 name: Invicta Medical Inc. class: INDUSTRY name: A... |
<|newrecord|> nctId: NCT06283004 id: 2024-1/30 briefTitle: Investigation of Walking Training With Different Slope Types in COPD Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-06-01 date: 2026-06-01 date: 2024-02-28 date: 2024-02-28 name: Acibadem University class: OTHER name: Bezmialem Vakif Uni... |
<|newrecord|> nctId: NCT06282991 id: B7461028 briefTitle: A Study to Learn About Lorlatinib in Patients With Non-Small Cell Lung Cancer Which Could Not Be Controlled overallStatus: COMPLETED date: 2020-07-22 date: 2021-01-18 date: 2021-01-18 date: 2024-02-28 date: 2024-02-28 name: Pfizer class: INDUSTRY briefSummary: T... |
This study is seeking participants who: |
* have lung cancer that could not be controlled. |
* have a type of gene called anaplastic lymphoma kinase. A gene is a part of your DNA that has instructions for making things your body needs to work. |
* have received at least 1 treatment before. |
All participants in this study had received lorlatinib. Lorlatinib is a tablet that is taken by mouth at home. They continued to take dacomitinib until their cancer was no longer responding. The study will look at the experiences of people receiving the study medicine. This will help to see if the study medicine is saf... |
<|newrecord|> nctId: NCT06282978 id: GEM-RANTAB id: 2023-504273-21 type: EUDRACT_NUMBER briefTitle: Study of Elranatamab for Relapsed or Refractory Myeloma in Patients Previously Exposed to Three-drug Classes overallStatus: RECRUITING date: 2023-11-23 date: 2025-05 date: 2029-12 date: 2024-02-28 date: 2024-03-06 name: ... |
Efficacy refers to the rate of Undetectable Measurable Residual Disease at 6 and 12 months as per International Myeloma Working Group (IMWG) criteria evaluated by the investigators. |
Safety refers to the measurement of: |
i) Adverse events (AEs) and serious adverse events (SAEs) according to standard clinical and laboratory tests (hematology and chemistry, physical examination, vital sign measurements, and diagnostic tests). |
ii) Incidence and severity of Cytokine Release Syndrome (CRS) and Immune effector cell associated neurotoxicity syndrome (ICANS) according to the American Society for Transplantation and Cellular Therapy (ASTCT) criteria. |
iii) Incidence and severity of other neurotoxicities. iv) Incidence of cytopenias and infections |
The study consists of a screening/baseline period, a treatment period, and a posttreatment follow-up period. The study includes a periodic review of safety data, that will be independently analyzed by the Data Safety Independent Committee (DSMC) and will recommend how to proceed with the study. conditions: Multiple Mye... |
<|newrecord|> nctId: NCT06282965 id: AngT-001 briefTitle: Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury acronym: ANGel T overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2027-09 date: 2027-09 date: 2024-02-28 date: 2024-02-28 name: University of Arizona class: O... |
The main questions this trial aims to answer are: |
* Is Angiotensin (1-7) safe? |
* Does Angiotensin (1-7) improve mental functioning and reduce physical signs of brain damage in people who have suffered a moderate to severe TBI? |
Participants will: |
* Complete 21 days of study treatment consisting of a once-daily injection. |
* Provide blood samples. |
* Undergo two magnetic resonance imaging (MRI) scans of the brain. |
* Complete specific tasks and questionnaires that allow researchers to evaluate the participant's brain and psychological functioning. |
Researchers will compare three groups: two groups that receive different doses of Angiotensin (1-7) and one group that receives a look-alike treatment with no active drug. This will allow researchers to see if the drug has any negative effects and whether it improves mental functioning and physical signs of brain damag... |
<|newrecord|> nctId: NCT06282952 id: 198/2023 briefTitle: NEwborn Infant of a Mother With Obesity - Fecal Microbiome Transplantation, RCT acronym: NEMO-FMT overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-12-31 date: 2028-12-31 date: 2024-02-28 date: 2024-02-28 name: Oulu University Hospital class: OTHER n... |
* Could fecal transplant be used improve gut microbiota and prevent overweight or obesity. |
* Is the source of colonization a modifiable factor and can it be changed by using an early fecal microbiota transplant. conditions: Fecal Microbiota Transplantation conditions: Cesarean Section conditions: Overweight and Obesity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL in... |
<|newrecord|> nctId: NCT06282939 id: 20234314 briefTitle: Optima Coil Performance in The Interventional Management of Intracranial Aneurysms Registry acronym: OPTIMA overallStatus: RECRUITING date: 2023-11-01 date: 2026-12-01 date: 2027-12-01 date: 2024-02-28 date: 2024-02-28 name: HCA Healthcare Research Institute cla... |
The primary objective of this registry is to evaluate the safety and effectiveness of the OptimaTM Coil System, including the OptiMAX Coils, in the real-world treatment of intracranial aneurysms. Imaging will be analyzed by a designated core neuroimaging lab to assess procedural success and aneurysm occlusion rates. In... |
<|newrecord|> nctId: NCT06282926 id: 324811 briefTitle: Role of 3D Echocardiography Knowledge-based Reconstruction in ACHD overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-06 date: 2025-09 date: 2024-02-28 date: 2024-02-28 name: Guy's and St Thomas' NHS Foundation Trust class: OTHER name: Manchester Metropoli... |
As part of the validation study, the reproducibility of the TTE-3DKBR in assessing RV volume and EF will also be tested in a group of healthy adult volunteers. Additionally, TTE-3DKBR evaluation will be compared in both groups to the conventional 2D echocardiography measurements used in routine clinical practice, such ... |
Another objective of the study is also to evaluate the effects of chronic RV volume overload with an interval of one-year follow-up using TTE-3DKBR and compare it with the conventional non-geometric echocardiography measurements, particularly with GLS. |
The study will end when the required number of patients have been enrolled and when the last subject undergoes the research dataset acquisition. The study may be terminated prematurely if it becomes apparent that the recruitment target cannot be met within the projected recruitment phase. conditions: Tetralogy of Fallo... |
<|newrecord|> nctId: NCT06282913 id: ---Oncology-Nursing-2024--- briefTitle: The Effect of Mindfulness Meditation overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-11 date: 2025-12 date: 2024-02-28 date: 2024-02-28 name: Gulhane Training and Research Hospital class: OTHER_GOV briefSummary: Cancer is a disease ... |
<|newrecord|> nctId: NCT06282900 id: 2024-1/15 briefTitle: Pain and Screen Addiction in University Students overallStatus: RECRUITING date: 2024-03-04 date: 2024-05 date: 2024-06 date: 2024-02-28 date: 2024-03-08 name: Acibadem University class: OTHER briefSummary: One of the most important factors why young people spe... |
The primary purpose of this study is to investigate the relationship between university students' use of various screen-based devices, the time they spend in front of the screen, and the number of painful areas they report on the body. Our secondary aim is to evaluate the relationship between pain, and screen time, and... |
<|newrecord|> nctId: NCT06282887 id: 2021-IIT-002 briefTitle: Effects of Music Therapy on Psychological States Among Cancer Patients Undergoing MRI Scans and A Relevant Mediator overallStatus: RECRUITING date: 2021-11-09 date: 2024-11-10 date: 2024-11-10 date: 2024-02-28 date: 2024-02-28 name: Guangzhou Concord Cancer ... |
Radiographers are blinding to avoid biases. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 80 type: ESTIMATED name: Music therapy measure: Anxiety measure: Symptom distress measure: Relaxation measure: Pulse rates measure: Respiration rate measure: Scanning efficiency measure: Patient satisfaction level measure... |
<|newrecord|> nctId: NCT06282874 id: CTONG2303 briefTitle: Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-07-01 date: 2027-03-01 date: 2024-02-28 date: 2024-02-28 name: Guangdong Association of Clinical Trials class: O... |
<|newrecord|> nctId: NCT06282861 id: ANTES B+ id: 2023-507304-32 type: EUDRACT_NUMBER briefTitle: ANTES B+ Clinical Trial acronym: ANTES B+ overallStatus: RECRUITING date: 2024-02-29 date: 2025-09 date: 2025-09 date: 2024-02-28 date: 2024-03-05 name: Fundacio Privada Mon Clinic Barcelona class: OTHER name: GlaxoSmithKl... |
* 1 moderate exacerbation in the previous year |
* CAT≥10 despite current treatment with LABA -LAMA |
* Blood eosinophil levels of ≥150 cells/ml |
the investigators further hypothesize that B+ patients could benefit from triple therapy treatment (LABA-LAMA + Inhaled Corticosteroids). Therefore, the main goal of this clinical trial is to compare the efficacy of Trelegy (triple therapy) in improving clinical control in GOLD B+ patients with chronic obstructive dise... |
The clinical control is a validated composite endpoint that includes two domains, the patient's stability, and the impact of the disease. |
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