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<|newrecord|> nctId: NCT06281925 id: 22-01363 briefTitle: Cryotherapy & Oxaliplatin overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-10-31 date: 2025-12-31 date: 2024-02-28 date: 2024-03-29 name: NYU Langone Health class: OTHER briefSummary: The primary objective of this study is to determine if cryotherapy i... |
<|newrecord|> nctId: NCT06281912 id: 4504/23 briefTitle: Impact of Anti PD-1 Therapy in Children, Adolescents and Young Adults (CAYA) Melanoma Patients acronym: MELCAYA overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-11 date: 2024-11 date: 2024-02-28 date: 2024-02-28 name: Azienda Ospedaliera di Perugia clas... |
<|newrecord|> nctId: NCT06281899 id: 01/2022 briefTitle: Effect of Low Protein Diet on Top of Dapagliflozin on Chronic Kidney Disease in Patients With Type 2 Diabetes Mellitus acronym: PRODAPA-CKD overallStatus: RECRUITING date: 2022-01-01 date: 2024-12-31 date: 2025-03-31 date: 2024-02-28 date: 2024-02-28 name: Anemia... |
<|newrecord|> nctId: NCT06281886 id: GASTO-10107 briefTitle: Induction Immuno-chemotherapy and Concurrent Chemoradiotherapy With or Without Apatinib in Unresectable, Locally Advanced Esophageal Squamous Cell Carcinoma overallStatus: RECRUITING date: 2023-12-01 date: 2026-12-01 date: 2026-12-01 date: 2024-02-28 date: 20... |
<|newrecord|> nctId: NCT06281873 id: 0645 briefTitle: Closure of Oroantral Fistula (OAF) Using Platelet Rich Fibrin With Middle Meatal Antrostomy overallStatus: COMPLETED date: 2023-03-27 date: 2023-09-01 date: 2024-02-07 date: 2024-02-28 date: 2024-02-28 name: Alexandria University class: OTHER briefSummary: the study... |
<|newrecord|> nctId: NCT06281860 id: PITHAC id: 2023-00099 type: REGISTRY domain: BASEC briefTitle: Treatment Pleural Carcinosis of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin Administration acronym: PITHAC overallStatus: RECRUITING date: 2023-11-24 date: 2025-12-01 date: 2026-02-01 date: 2024-02-28 date: ... |
<|newrecord|> nctId: NCT06281847 id: CCTx-001-AML-001 briefTitle: An Adaptive Open-label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of CCTx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients With Relapsed/Refractory Acute Myeloid Leukaemia acronym: RESOLVE AML001 over... |
* The pre-treatment period will consist of screening for eligibility, leukapheresis and a pre-treatment evaluation (prior to Lymphodepleting Chemotherapy (LDC)). |
* The treatment period will start with LDC, followed by CCTx-001 infusion 2 to 7 days after completion of LDC. A first response evaluation will be performed at approximately 28 days after CCTx-001 infusion. |
* The post-treatment period will consist of further clinical activity and safety follow-up visits at regular timepoints after CCTx-001 infusion, starting after the Month 3 visit up to the Month 24 visit. |
* The long-term follow-up period will start after the Month 24 visit up to 15 years post CCTx-001 infusion. primaryPurpose: TREATMENT masking: NONE count: 143 type: ESTIMATED name: CCTx-001 measure: Phase 1: To evaluate the safety, tolerability, and to define the recommended phase 2 dose (RP2D) of CCTx-001 measure: Pha... |
<|newrecord|> nctId: NCT06281834 id: 2024P000306 briefTitle: Dolutegravir Pharmacokinetics During Weekly Rifapentine/Isoniazid for TB Prevention overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-02 date: 2027-06 date: 2024-02-28 date: 2024-02-28 name: Brigham and Women's Hospital class: OTHER name: APIN Public... |
<|newrecord|> nctId: NCT06281821 id: 4947 [Study 2] briefTitle: Mobile App-based Approach for Reducing Pain and Hazardous Drinking: a Pilot Study overallStatus: RECRUITING date: 2024-02-06 date: 2024-12-01 date: 2024-12-01 date: 2024-02-28 date: 2024-02-28 name: Boston University Charles River Campus class: OTHER name:... |
<|newrecord|> nctId: NCT06281808 id: R490 briefTitle: Photon Counting Detector CT Image Quality overallStatus: NOT_YET_RECRUITING date: 2024-02-28 date: 2026-09-01 date: 2026-12-31 date: 2024-02-28 date: 2024-02-28 name: Reto Sutter, MD class: OTHER briefSummary: This study aims to compare subjective image quality and ... |
<|newrecord|> nctId: NCT06281795 id: 1.24. briefTitle: Neuromodulation of the Autonomic Nervous System in Athletes acronym: NANSA overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-01-31 date: 2026-01-31 date: 2024-02-28 date: 2024-02-28 name: Bakulev Scientific Center of Cardiovascular Surgery class: OTHER_... |
<|newrecord|> nctId: NCT06281782 id: PRP with topical retinoids briefTitle: Platelet-rich Plasma With Topical Retinoids Versus Topical Retinoids Alone in Acne Vulgaris overallStatus: RECRUITING date: 2024-01-01 date: 2024-04 date: 2024-05 date: 2024-02-28 date: 2024-02-28 name: Assiut University class: OTHER briefSumma... |
Platelet-rich plasma (PRP) is prepared by simple centrifugation of whole blood to concentrate platelets and simultaneously remove red blood cells. The resultant supernatant is the PRP that contains various growth factors, including platelet-derived growth factor (PDGF), transforming growth factor (TGF), fibroblast grow... |
Topical retinoids are used in the treatment of both noninflammatory and inflammatory acne.Food and Drug Administration (FDA) approved three topical retinoids: adapalene, tazarotene, and tretinoin. These agents help normalize follicular keratinization and decrease keratinocyte cohesiveness, thereby reducing follicular o... |
Updates from the Global Alliance on Improving Outcomes in Acne consider topical retinoids as first-line therapy, individually or in combination with benzoyl peroxide. However, the common side effects of skin irritation and discomfort may impede adherence to long-term therapy. |
For patients with acne, combination therapy with a topical retinoid and platelet-rich plasma (PRP) has not yet been tested. |
PRP with topical retinoids will be evaluated and campared with topical retinoids alone in acne tretment. conditions: Acne Vulgaris studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Topical retinoids versus topical retinoids wit PRP in acne vulgaris tre... |
<|newrecord|> nctId: NCT06281769 id: NL82101.000.22 briefTitle: Prostate Cancer Detection Rate of Targeted Biopsies With PCaVision overallStatus: RECRUITING date: 2024-02-26 date: 2025-01-01 date: 2025-01-01 date: 2024-02-28 date: 2024-03-06 name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) class:... |
<|newrecord|> nctId: NCT06281756 id: STUDY00022285 id: 1UG3HL161342-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/1UG3HL161342-01A1 briefTitle: Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia overallStatus: RECRUITING date: 2024-03-14 date: 2027-02 date: 2028-02 da... |
<|newrecord|> nctId: NCT06281743 id: LST-Ped Survey briefTitle: Attitudes to Decisions to Withdraw or Withhold Life-sustaining Treatments in Critically Ill Children acronym: LSTPedSurvey overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-12 date: 2026-12 date: 2024-02-28 date: 2024-03-15 name: Göteborg Universi... |
<|newrecord|> nctId: NCT06281730 id: 23-009197 briefTitle: Use of New Generation Fetoscopes in Pregnancies Affected by Fetal Diseases Amenable to Fetoscopy Therapy overallStatus: RECRUITING date: 2024-05 date: 2044-02 date: 2044-02 date: 2024-02-28 date: 2024-04-09 name: Mayo Clinic class: OTHER briefSummary: The Resea... |
<|newrecord|> nctId: NCT06281717 id: IRB-P00045047 briefTitle: A Pilot Study on the Role of Fetal Endotracheal Occlusion (FETO) in Fetuses With Severe Congenital Diaphragmatic Hernia overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2027-03-01 date: 2030-08-30 date: 2024-02-28 date: 2024-02-28 name: Alireza Sham... |
This study will enroll 10 pregnant participants to undergo the FETO procedure at a gestational age of 27 weeks 0 days to 29 weeks 6 days. The participant will be monitored for a few weeks, and then the FETO removal procedure will be performed ideally at 34 weeks 0 days to 34 weeks 6 days, but may be indicated earlier a... |
<|newrecord|> nctId: NCT06281704 id: AK101-102 briefTitle: A Study of AK101 in Subjects With Moderately to Severely Active Ulcerative Colitis overallStatus: COMPLETED date: 2020-11-26 date: 2022-05-17 date: 2022-12-31 date: 2024-02-28 date: 2024-02-28 name: Akeso class: INDUSTRY briefSummary: This is a Phase Ib clinica... |
<|newrecord|> nctId: NCT06281691 id: GreenBladder briefTitle: GreenBladder - Early Detection of Bladder Cancer in Residents in Greenland Using a Urinary Marker and a Mobile Cystoscopy Unit overallStatus: ENROLLING_BY_INVITATION date: 2023-04-28 date: 2024-07-01 date: 2025-11-30 date: 2024-02-28 date: 2024-02-28 name: J... |
<|newrecord|> nctId: NCT06281678 id: CIBI363A202 briefTitle: A Study of IBI363 in Subjects With Advanced Solid Malignancies overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2026-03-01 date: 2026-12-31 date: 2024-02-28 date: 2024-02-28 name: Innovent Biologics (Suzhou) Co. Ltd. class: INDUSTRY briefSummary: This... |
<|newrecord|> nctId: NCT06281665 id: STUDY23080099 id: K23HL168356 type: NIH link: https://reporter.nih.gov/quickSearch/K23HL168356 briefTitle: Treatment With Aspirin After Preeclampsia: TAP Trial acronym: TAP overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-01 date: 2026-04-01 date: 2024-02-28 date: 20... |
<|newrecord|> nctId: NCT06281652 id: Cognichess briefTitle: Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline acronym: Cognichess overallStatus: RECRUITING date: 2024-02-13 date: 2025-02-13 date: 2025-02-13 date: 2024-02-28 date: 2024-03-01 name: University of Milano Bicocca class: OTHE... |
* Do Go and Chess improve cognition? |
* Is a game better than the other? Is the effect of both games on cognition synergistic? |
* Do Go and Chess improve quality of life? |
* Do Go and Chess improve mood? |
* Do Go and Chess improve lifestyle? |
Participants will be randomized to one of four groups: |
* Group intervention with Go, once a week, for 12 weeks |
* Group intervention with Chess, once a week, for 12 weeks |
* Group intervention with Go and Chess, twice a week, for 12 weeks |
* Control group conditions: Mild Cognitive Impairment conditions: Subjective Cognitive Decline studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 80 type: ESTIMATED name: Go classes name: Chess classes measure: General cognition measure: Di... |
<|newrecord|> nctId: NCT06281639 id: RAPID briefTitle: RAPID: a Comparison Study of a Novel Ultrasound Device of Automated Congenital Heart Imaging overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-04-01 date: 2024-02-28 date: 2024-02-28 name: University of Minnesota class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06281626 id: 2024_RIPH_01_Preservatif briefTitle: Use of the Free Male Condom Scheme in Young Adults Aged 18 to 25 acronym: Préservatif overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-05-01 date: 2024-10-01 date: 2024-02-28 date: 2024-02-28 name: Université de Reims Champagne-Arden... |
In France, 40% of STIs concern young people aged 15 to 25. The national public health strategy aims to stem the circulation of HIV and eliminate STIs as a major public health problem by 2030. To achieve this, several measures have been implemented: reimbursement of male condoms on prescription (2018), 100% free contrac... |
<|newrecord|> nctId: NCT06281613 id: 2024-AMCOPTEO briefTitle: Comparison of AMCOP Bioactivator and High-pull Headgear in Treating Skeletal Class II Hyperdivergent Pediatric Patients overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-03 date: 2024-04-01 date: 2024-04-05 date: 2024-02-28 date: 2024-03-08 name: Universit... |
Cephalometric radiographs from pediatric patients treated at the Unit of Orthodontics and Pediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy and at the private practice of Dr. Cardarelli, Isernia, Italy will be collected. |
Cephalometric tracing from Giannì analysis will be performed at the baseline (T0) and after 18 months of treatment (T1). conditions: Skeletal Malocclusion studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 40 type: ESTIMATED name: AMCOP group name: High-pull headgear measure... |
<|newrecord|> nctId: NCT06281600 id: REC: 23/SW/0042 id: 326109 type: OTHER domain: IRAS ID briefTitle: An Intervention Study Using HMOs to Improve IBS Symptoms acronym: GUT-HEAL-IBS overallStatus: RECRUITING date: 2024-02-20 date: 2025-08-20 date: 2025-09-20 date: 2024-02-28 date: 2024-02-29 name: Glenn Gibson class: ... |
IBS is a highly prevalent gastrointestinal (GI) disorder with significant negative impact on quality of life of patients and high healthcare costs. Although prognosis of IBS is benign, it is a disorder that poses a considerable burden on the individual sufferer and society. Patients typically present with chronic abdom... |
IBS is suggested to be a disorder of gut-brain interaction, and alterations of the microbiota-host interactions at the mucosal border may cause symptoms such as those previously mentioned. Therefore, microbiota-targeted interventions may benefit some people with IBS by beneficially modulating the gut microbiome. Severa... |
Breastmilk is known to play a crucial role in the development of infants, providing key nutrients and immunological compounds important for initial protection against pathogens \[9\]. Among these compounds, human milk oligosaccharides (HMOs) represent the third most important component of breastmilk after lipids and la... |
Studies looking specifically at HMO interventions in humans with IBS are sparse. These include a phase II, parallel, RCT in 58 IBS volunteers by Iribarren et al. and an open-label trial with 245 IBS participants from 17 sites across USA by Palsson et al.. None have been sufficiently powered to a degree which could infl... |
Using the global systems biology approach not yet applied to this research question, a pre-competitive approach to selecting a candidate HMO, and a crossover feasibility trial design, the investigators hope to forge a new direction in establishing the merits of HMO use in IBS. |
This study will look specifically at patients with all IBS subtypes, an area where there is a real therapeutic gap and clinical need for safe, effective therapy to improve quality of life. Participants will be randomly allocated to be given either the HMO or a placebo, with neither the patient nor the researchers knowi... |
With this proposal, the aim is to explore how HMOs affect the gut microbiota and whether they can do so in a manner that positively influences patients with IBS. The investigators also hope to develop molecular profiling as part of a research toolkit for gut microbiome-based HMO supplement studies. conditions: Irritabl... |
<|newrecord|> nctId: NCT06281587 id: SNFyodorov briefTitle: Pathogenetic Risk Factors for Corneal Graft Rejection overallStatus: COMPLETED date: 2011-01 date: 2019-01 date: 2019-01 date: 2024-02-28 date: 2024-02-28 name: The S.N. Fyodorov Eye Microsurgery State Institution class: OTHER_GOV briefSummary: There are many ... |
Investigators analysed data from 493 patients who underwent penetrating keratoplasty between 2011 and 2019. Keratoplasty outcomes were followed up at subsequent clinic visits until December 2021. Then, 93 medical records were selected (taking into account the completeness of the medical records) and divided into two gr... |
<|newrecord|> nctId: NCT06281574 id: S67346 briefTitle: What Are the Determinants for RTW After SA acronym: RTW after SA overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-13 date: 2025-02-01 date: 2025-02-01 date: 2024-02-28 date: 2024-03-06 name: Universitaire Ziekenhuizen KU Leuven class: OTHER briefSummary: Shoulde... |
Recent literature shows that the majority patients is able to resume their work following shoulder arthroplasty. |
This study aims to analyze the RTW percentage in a Belgian cohort of patients with a shoulder replacement. This study hopes to identify factors that might influence the RTW. conditions: Shoulder Arthroplasty studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED name... |
<|newrecord|> nctId: NCT06281561 id: FirstAHXiamenU-YB briefTitle: Dexmedetomidine Premedication for Post-anaesthesia Sleep Disturbance overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-11-30 date: 2024-12-31 date: 2024-02-28 date: 2024-04-16 name: The First Affiliated Hospital of Xiamen University class: O... |
Participants will receive total intravenous propofol anaesthesia after dexmedetomidine nasal spray. Sleep quality will be monitored by using a Wearable devices and the PSQI which was used to assess sleep quality 1,2 days before the surgery and 1,3,7 days after surgery. |
Researchers will compare the effects of 0.2 or 0.5 ug/kg dexmedetomidine to see if it help improve postanesthesia sleep quality. conditions: Postoperative Sleep Disturbance studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked:... |
<|newrecord|> nctId: NCT06281548 id: 23-2937 id: 1F31DA058452 type: NIH link: https://reporter.nih.gov/quickSearch/1F31DA058452 briefTitle: Feasibility and Acceptability of a Stigma Text Message Intervention for People Who Use Drugs overallStatus: RECRUITING date: 2024-02-29 date: 2024-04-30 date: 2024-04-30 date: 2024... |
This study is a single-group pilot trial to determine whether the intervention is feasible and acceptable to participants. All participants will receive the intervention. The primary outcomes are changes in stigma resistance and self-stigma from baseline to 4-week follow-up using self-report. Implementation and process... |
<|newrecord|> nctId: NCT06281535 id: 21789 briefTitle: Early Versus Conventional Loading for Fully Guided Immediate Implant Placement overallStatus: NOT_YET_RECRUITING date: 2024-02-20 date: 2024-05-31 date: 2024-06-15 date: 2024-02-28 date: 2024-02-28 name: Ain Shams University class: OTHER name: Assiut University bri... |
<|newrecord|> nctId: NCT06281522 id: University of Health Sciences briefTitle: The Importance of Inflammatory Markers Calculated From Preoperative and Postoperative Peripheral Blood Results in the Diagnosis and Treatment of Patients Operated for Hydatid Cyst of the Lung (Lung Echinococcus Granulosus) acronym: Echinococ... |
<|newrecord|> nctId: NCT06281509 id: S68374 briefTitle: Palmaris Longus Muscle and Dupuytren acronym: Palmaris overallStatus: RECRUITING date: 2024-02-16 date: 2025-02-01 date: 2025-02-01 date: 2024-02-28 date: 2024-03-07 name: Universitaire Ziekenhuizen KU Leuven class: OTHER briefSummary: Dupuytren disease is a medic... |
<|newrecord|> nctId: NCT06281496 id: Rigshospitalet, Hematology briefTitle: AlloCare - Support and Management of Late Effects After Allogeneic Hematopoietic Stem Cell Transplantation acronym: AlloCare overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-10-01 date: 2026-12-01 date: 2024-02-28 date: 2024-02-29 ... |
<|newrecord|> nctId: NCT06281483 id: APCs in chronic skin ulcers briefTitle: PRP Versus PRF Versus Conventional Treatment in Chronic Non-healing Skin Ulcers overallStatus: RECRUITING date: 2024-01-01 date: 2025-01-01 date: 2026-01 date: 2024-02-28 date: 2024-02-28 name: Kafrelsheikh University class: OTHER name: Helwan... |
<|newrecord|> nctId: NCT06281470 id: WS016-Ⅰ-01 briefTitle: The Safety and Tolerability of WS016 in Healthy Chinese Volunteers overallStatus: COMPLETED date: 2023-02-13 date: 2023-06-15 date: 2023-06-15 date: 2024-02-28 date: 2024-02-28 name: Waterstone Pharmaceutical (Wuhan) Co., LTD. class: INDUSTRY briefSummary: Thi... |
<|newrecord|> nctId: NCT06281457 id: 5-24-0030: 2.1 id: R01EY035300 type: NIH link: https://reporter.nih.gov/quickSearch/R01EY035300 briefTitle: Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Task Demands (Expt 2.1) overallStatus: RECRUITING date: 2024-04 date: 2024-05 date: 2024-05 date: 202... |
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