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Study population: 50 patients with therapy refractory GP on dietary advices, prokinetics and possibly tube feeding (gastric rest) who have already been referred for additional treatment options in the form of PEG-J/ G-POEM. |
Intervention: Group 1 will receive G-POEM treatment and group 2 will receive PEG-J treatment. |
Main study parameters/endpoints: A clinically meaningful treatment success six months after G-POEM treatment, measured using the GCSI-score defined as a decrease of 1 or more point. conditions: Gastroparesis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATME... |
<|newrecord|> nctId: NCT06372119 id: 13/23/DD-BVMD briefTitle: Letrozole-stimulated Cycle Strategy Versus Artificial Cycle Strategy (LETSACT) overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-04 date: 2024-04-17 date: 2024-04-17 name: Mỹ Đức Hospital class: OTHER briefSummary: The goal of this ra... |
• Does the letrozole-stimulated cycle strategy for endometrial preparation result in a higher live birth rate compared to the artificial cycle strategy in women with irregular menstrual cycles after one cycle of endometrial preparation? |
Participants will undergo screening before endometrial preparation for frozen embryo transfer, following which they will be randomly assigned to one of two groups: LETS or AC. In the LETS group, investigators will prescribe Femara® 2.5 milligrams (Novartis, Switzerland) at a dose of 5 milligrams/day for 5 days to stimu... |
<|newrecord|> nctId: NCT06372106 id: MA_PM_Mountain_2022_11496 briefTitle: Project Mountain - Comparing SpO2 and SaO2 for Accuracy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2024-12 date: 2024-04-17 date: 2024-04-17 name: Philips Clinical & Medical Affairs Global class: INDUSTRY briefSummary: T... |
<|newrecord|> nctId: NCT06372093 id: PMH 2/11AII briefTitle: Evaluation of Bilirubin Measurements in Newborns From Smartphone Digital Images in a Population in Botswana overallStatus: COMPLETED date: 2023-03-16 date: 2024-02-26 date: 2024-02-26 date: 2024-04-17 date: 2024-04-17 name: Picterus AS class: INDUSTRY name: U... |
The specific objectives for this study are: |
i. To assess the correlation between bilirubin level measurements obtained by Picterus Jaundice Pro with Total Serum Bilirubin (TSB), and TcB, in newborns with high melanin content in the skin. |
ii. To determine the accuracy of Picterus Jaundice Pro in newborns with high melanin content in the skin. conditions: Jaundice, Neonatal studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: SCREENING masking: NONE count: 172 type: ACTUAL name: Picterus Jaundice Pro measure... |
<|newrecord|> nctId: NCT06372080 id: 19/SPS/054 briefTitle: Resistance Training and Hydrolyzed Collagen Supplementation in Healthy Young Adults overallStatus: COMPLETED date: 2020-01-06 date: 2021-09-29 date: 2023-03-31 date: 2024-04-17 date: 2024-04-17 name: Liverpool John Moores University class: OTHER briefSummary: ... |
The main questions it aims to answer are: |
* Does resistance training with hydrolyzed collagen ingestion lead to greater changes in tendon properties than resistance training alone? |
* Does resistance training with hydrolyzed collagen ingestion lead to greater changes in muscle size than resistance training alone? |
Participants will be randomly assigned to collagen or placebo groups. Participants will perform resistance training three times per week for 10 weeks and hydrolyzed collagen or maltodextrin will be given to collagen or placebo group respectively immediately before each resistance training session. Also, vitamin C will ... |
Researchers will compare collagen and placebo groups to see if hydrolyzed collagen ingestion with resistance exercise would have beneficial effects on changes in muscle and tendon more than resistance training alone. Therefore, using isokinetic dynamometer and ultrasonography, maximal leg strength, morphological, mecha... |
<|newrecord|> nctId: NCT06372067 id: 17378 briefTitle: IM Screw vs. K-wire Fixation of Proximal/Middle Phalanx Fractures acronym: HANDFIX overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-12-31 date: 2026-03-01 date: 2024-04-17 date: 2024-04-17 name: McMaster University class: OTHER briefSummary: When peopl... |
<|newrecord|> nctId: NCT06372054 id: TORNADO briefTitle: TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models overallStatus: RECRUITING date: 2024-02-05 date: 2025-02-05 date: 2027-02-05 date: 2024-04-17 date: 2024-04-17 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlin... |
<|newrecord|> nctId: NCT06372041 id: 944/B briefTitle: Transcranial Alternating Current Stimulation in Cerebral Palsy (BOOSTTACS) acronym: BOOSTTACS overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-03-14 date: 2026-05-14 date: 2024-04-17 date: 2024-04-17 name: IRCCS Eugenio Medea class: OTHER name: IRCCS N... |
<|newrecord|> nctId: NCT06372028 id: 944/A briefTitle: Non Invasive Vagus Nerve Stimulation in Cerebral Palsy (BOOSTTVNS) acronym: (BOOSTTVNS) overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-03-14 date: 2026-05-14 date: 2024-04-17 date: 2024-04-17 name: IRCCS Eugenio Medea class: OTHER name: IRCCS Nationa... |
<|newrecord|> nctId: NCT06372015 id: RC2023-24 briefTitle: Changes in the Lipidomic, Immunological and miRNA Profile in Patients Undergoing a Dietary Program or Bariatric Surgery overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-01 date: 2026-06-01 date: 2024-04-17 date: 2024-04-17 name: Azienda Ospedali... |
The association of these pathologies compromises the patient's survival and quality of life. The multifactorial origin of obesity makes its etiopathology difficult to manage. It is often possible to follow only one therapeutic strategy, especially after the so-called standard treatments, such as dietary intervention an... |
Bariatric surgery refers to all those interventions aimed at reducing weight in those suffering from obesity, and treating the diseases associated with it. |
Among the different types of bariatric surgery, the techniques most used in common clinical practice are intragastric balloons, gastric by pass (RYGB) and sleeve gastrectomy. |
The choice of the surgeon, assisted by the multidisciplinary team, is binding in the choice of the type of operation to which the patient will be subjected. conditions: Obesity conditions: Liver Disease Parenchymal studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: OTHER count: 60 type: ESTIMATE... |
<|newrecord|> nctId: NCT06372002 id: 05/23 briefTitle: Effectiveness and Cost-Effectiveness of Cognitive Stimulation Therapy - Spain (CST-ES) in People Living With Dementia overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-16 date: 2024-07-31 date: 2024-07-31 date: 2024-04-17 date: 2024-04-17 name: Instituto de Mayore... |
The evaluation will be conducted as a pragmatic multicenter randomized controlled clinical trial. Participants will be randomized to receive 7 weeks of CST-ES followed by 24 weeks of maintenance CST-ES (intervention group) or to continue their usual treatment (control group). conditions: Dementia conditions: Neurocogni... |
* First Phase: Participants who meet the inclusion criteria will be randomized to the CST-ES intervention group or a treatment-as-usual control group. Participants assigned to the intervention group will receive two sessions of CST-ES per week for 7 weeks, also they will continue their usual treatment. Participants in ... |
* Second Phase: After the first phase is completed, participants assigned to the intervention group will receive one session of maintenance CST-ES per week for 24 weeks besides continuing their usual treatment, whereas participants in the control group will continue their usual treatment during this second phase. prima... |
The CRE Alzheimer professional responsible for randomization and data analysis will also be blinded. |
The participants and the technician performing the intervention cannot be blinded due to the nature of the intervention. whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 683 type: ACTUAL name: Cognitive Stimulation Therapy (CST) measure: Cognitive functioning assessed through Alzheimer's Disease Assessment S... |
<|newrecord|> nctId: NCT06371989 id: 19/160 briefTitle: Vacuum Assisted Biopsy and Surgery Correlation in HER2 and TN Breast Cancer Subtypes MRI Responders After Neoadjuvant Therapy: BISUCO TRIAL acronym: BISUCO overallStatus: COMPLETED date: 2019-03-11 date: 2021-03-20 date: 2022-12-20 date: 2024-04-17 date: 2024-04-1... |
Advancements in neoadjuvant systemic treatments (NST) for HER2 positive and triple-negative (TN) breast cancer (BC) subtypes have led to high rates of pathologic complete response (pCR), raising questions about the necessity of subsequent surgery, especially for those undergoing adjuvant radiotherapy. While Magnetic Re... |
OBJECTIVE: |
This study aims to establish the diagnostic efficacy of image-guided vacuum-assisted biopsy (VAB) in assessing pathological complete response (pCR) after NST in HER2 positive or TN breast cancer subtypes, particularly those showing post NST-MRI complete or almost complete response. |
METHODS: |
A prospective study was conducted at "Hospital Universitario 12 de Octubre de Madrid" from June 25, 2018, to October 25, 2029. Twenty-five patients with HER2-positive or TN operable invasive ductal carcinoma (IDC) BC subtype, at stages cT1-3/N0-2 undergoing primary NST and showing complete or almost complete response o... |
<|newrecord|> nctId: NCT06371976 id: APH240230 briefTitle: Evaluation of the HPA Axis in Patients With Vasoplegic Syndrome After Cardiac Surgery acronym: VASOCORT overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-04-01 date: 2025-04-01 date: 2024-04-17 date: 2024-04-17 name: Assistance Publique - Hôpitaux d... |
Tandem mass spectrometry (LC-MS/MS) assays can be used to measure steroid metabolites (steroidome), enabling more precise exploration of the corticotropic axis. |
The aim of this study is to evaluate, on an exploratory basis, the impact of the presence of a post-cardiac surgery vasoplegic syndrome on adrenal function by steroidome mapping (LC-MS/MS). conditions: Vasoplegic Syndrome in Adult Cardiac Surgery studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROS... |
<|newrecord|> nctId: NCT06371963 id: LinnaeusU REDs briefTitle: Relative Energy Deficiency in Sports (REDs) in Swedish Athletes acronym: REDs-Sweden overallStatus: RECRUITING date: 2022-05-10 date: 2024-05 date: 2026-12 date: 2024-04-17 date: 2024-04-18 name: Linnaeus University class: OTHER name: Swedish Olympic Commi... |
<|newrecord|> nctId: NCT06371950 id: 123608 briefTitle: Gut Microbiome in Orthopaedics acronym: GUMBO overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-01 date: 2027-01-01 date: 2024-04-17 date: 2024-04-17 name: Lawson Health Research Institute class: OTHER briefSummary: Patients having knee replacement ... |
This study is a randomized, controlled, double-blinded trial comparing probiotic use with placebo in post-menopausal women undergoing primary total knee replacement. The main questions it aims to answer are: |
* to compare implant migration between groups from baseline to six weeks post-surgery |
* to compare bone density and joint inflammation between groups from baseline to six weeks post-surgery |
* to compare gut microbiome composition and patient-reported outcome measures between groups from baseline to six weeks post-surgery conditions: Total Knee Arthroplasty conditions: Inflammation conditions: Gastrointestinal Health studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL pr... |
<|newrecord|> nctId: NCT06371937 id: 120687 briefTitle: iPSC Biobank of Biomarkers Diversity in Cardiovascular Disease acronym: INFERENCE overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2033-06-30 date: 2033-06-30 date: 2024-04-17 date: 2024-04-25 name: Lawson Health Research Institute class: OTHER name: Green... |
<|newrecord|> nctId: NCT06371924 id: KCH23-156 briefTitle: Immunometabolism of Machine Perfusion Strategies acronym: iMaps overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-05-31 date: 2026-05-31 date: 2024-04-17 date: 2024-04-17 name: King's College Hospital NHS Trust class: OTHER name: King's College London ... |
The discarded organs are mostly those coming from donors who have died due to cardiac arrest (called 'donation after circulatory death' or DCD), with only 27% of them being used in the UK. The quality of these DCD organs could be improved by changing how they are preserved after being removed from the donor. The most c... |
There are three MP methods being used in patients: 1) normothermic regional perfusion (NRP), which involves pumping the donor's blood through the liver after the donor has died but the liver is still in the donor's body; 2) normothermic machine perfusion (NMP), in which the liver is pumped with blood outside of the don... |
The iInvestigators plan to conduct a study where 36 DCD human livers will be split into three groups: SCS, NRP, and HOPE. After that, they will be put in NMP to confirm that they are good enough to be transplanted and to study the mechanisms through which NRP, SCS and HOPE work. conditions: Liver Transplantation studyT... |
i) SCS; ii)NRP; and iii) HOPE. This will be followed by a period of time in NMP in order to study the IRI response and determine if the quality of the livers is good enough to proceed to transplantation. This study will allow the doctors to decipher the mechanisms of liver IRI in humans in a much better way than what h... |
<|newrecord|> nctId: NCT06371911 id: 2023-A02762-43 briefTitle: Benefit of Adding Cureety TechCare Telemonitoring to Usual Care During Injectable Anticancer Treatment acronym: OPTIMACURE overallStatus: RECRUITING date: 2024-04-03 date: 2024-08-03 date: 2024-12-03 date: 2024-04-17 date: 2024-04-18 name: Centre Francois ... |
In France, the Centre François Baclesse in Caen (France) launched the OPTIMA program to optimize the prescription and preparation of chemotherapy in the ambulatory unit of the hospital. |
A prospective study validating the OPTIMA program found that the prescription of chemotherapy was accurate with significantly reduced waiting times for patients between the planned appointment time and initiation of chemotherapyThe OPTIMA program is now part of usual care at the Centre François Baclesse. |
Following the positive impact of both the OPTIMA and "Star" programs, several French healthcare centers have implemented similar programs. However, a large proportion of the data during the program are collected by telephone, particularly outgoing calls (from the hospital staff to patients). Thus, implementing these pr... |
Since the deployment of the OPTIMA program (between 2014 and 2016), and other equivalent programs, more and more patients have asked for the telephone calls to be replaced by a web-based application. Indeed, patients do not always respond to the telephone calls made by hospital staff, thus forcing staff to repeat calls... |
Telemonitoring can collect blood test results and other patient data required to evaluate whether patients are apt for injectable cancer treatment. Telemonitoring can then identify the few patients that need to be contacted by hospital staff, thus reducing the number of outgoing telephone calls. |
There is growing evidence of the benefits of adding telemonitoring to usual care for patients undergoing cancer treatment. The benefits include the early detection of AEs, improved quality of life (QoL), fewer admissions to emergency rooms or hospitalization, the longer remaining on chemotherapy for patients, and exten... |
Cureety is a digital telemonitoring platform, specifically designed to monitor signs and symptoms of disease progression and AEs in cancer patients. The digital tool includes questionnaires for each class of medication to monitor patients' adverse events remotely. The data collected include blood results, treatment-rel... |
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