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Methods: A randomized clinical trial will be conducted to compare two interventions. Data collection will be through a questionnaire and scales for the evaluation of pain and edema, with women who experienced vaginal delivery and those who suffered 1st and 2nd-degree lacerations or episiotomies. |
Expected results: Reduction of pain, edema, and inflammatory processes with non-pharmacological techniques, leading to greater comfort and better postpartum recovery. conditions: Episiotomy; Complications conditions: Laceration studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER int... |
<|newrecord|> nctId: NCT06370897 id: 337421 briefTitle: Prediction & Mechanisms of Recovery Following IEDS overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-04 date: 2028-09 date: 2024-04-17 date: 2024-04-17 name: University of Plymouth class: OTHER briefSummary: Inner Ear Decompression sickness (IEDS) account... |
This project will investigate if and how people recover after an acute episode of IEDS and whether people who had IEDS in the past show changes in the central (brain) processing of vestibular function and in symptoms of dizziness, balance and posture. |
This project has two main parts. Part one is a prospective observational study where people with an acute onset of IEDS are serially monitored while they are receiving hyperbaric treatment and VR over 10-14 days. Part two is a retrospective observational study where who have had IEDS in the past 15 years are re-assesse... |
<|newrecord|> nctId: NCT06370884 id: SURG-2023-29833 briefTitle: Intestinal Microbiota Transplantation in Patients Undergoing Colon Resection overallStatus: RECRUITING date: 2024-02-01 date: 2025-10-01 date: 2026-02-01 date: 2024-04-17 date: 2024-04-17 name: University of Minnesota class: OTHER briefSummary: This is a ... |
<|newrecord|> nctId: NCT06370871 id: 1403-0006 id: 2022-502985-26-00 type: REGISTRY domain: CTIS (EU) id: U1111-1292-9594 type: REGISTRY domain: WHO Registry briefTitle: Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma overallStatus: NO... |
The purpose of this study is to compare a medicine called brigimadlin in combination with another medicine called ezabenlimab with chemotherapy. Brigimadlin is a so-called MDM2-p53 antagonist that is being developed to treat cancer. Ezabenlimab is an antibody that may help the immune system fight cancer. |
Participants are put into 3 groups by chance: |
* Ezabenlimab group: Participants receive ezabenlimab as an infusion into a vein every 3 weeks |
* Brigimadlin + ezabenlimab group: Participants take brigimadlin as tablets and receive ezabenlimab as an infusion into a vein every 3 weeks |
* Chemotherapy group: Participants get chemotherapy as an infusion into a vein on 2 days every 3 weeks. Chemotherapy is a combination of gemcitabine and docetaxel which is often used in the treatment of sarcoma. |
There are twice as many participants in the brigimadlin + ezabenlimab group and in the chemotherapy group, compared to those in the ezabenlimab group. |
Participants can continue treatment in the study as long as they benefit from it and can tolerate it. |
Doctors regularly check the size of the tumor and check whether it has spread to other parts of the body. The doctors also regularly check participants' health and take note of any unwanted effects. Participants in this study use an app on a mobile phone to regularly answer questions about their health and well-being. ... |
<|newrecord|> nctId: NCT06370845 id: 0000-00000; kt24timper briefTitle: Abundance of a Natural Odour in Human Cerebrospinal Fluid After Olfactory Exposure acronym: OLFO-Brain overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-08-31 date: 2024-10-30 date: 2024-04-17 date: 2024-04-17 name: University Hospital,... |
<|newrecord|> nctId: NCT06370832 id: 22-5171 briefTitle: Inspiratory Muscle Training in Lung Transplant Candidates overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-09-30 date: 2027-09-30 date: 2024-04-17 date: 2024-04-17 name: University Health Network, Toronto class: OTHER name: Canadian National Transpla... |
<|newrecord|> nctId: NCT06370819 id: NN9541-4923 id: U1111-1292-3441 type: OTHER domain: Universal Trial Number id: 2023-506381-32 type: OTHER domain: EU CT Number briefTitle: A Research Study Looking Into Blood Levels of the Medicine NNC0519-0130 in the Body in Participants With Normal or Reduced Kidney Function overa... |
<|newrecord|> nctId: NCT06370806 id: INTERAPNEA-Women briefTitle: Lifestyle Intervention for Obstructive Sleep Apnea in Women acronym: INTERAPNEA-W overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-01 date: 2025-12-01 date: 2024-04-17 date: 2024-04-17 name: Universidad de Granada class: OTHER name: Funda... |
<|newrecord|> nctId: NCT06370793 id: NBU-2024-011 briefTitle: Ningbo Severe Mental Disorders Cohort acronym: NEED overallStatus: ACTIVE_NOT_RECRUITING date: 2018-07-01 date: 2023-12-31 date: 2026-12-31 date: 2024-04-17 date: 2024-04-18 name: Ningbo University class: OTHER name: The Affiliated Kangning Hospital of Ningb... |
Currently, NEED has accumulated data on more than 50,000 patients with severe mental disorders and obtained multi-dimensional longitudinal information through long-term follow-up and data linkage. All diseases follow the World Health Organization International Classification of Diseases 10th Edition (ICD-10) for clinic... |
<|newrecord|> nctId: NCT06370780 id: 5UG3AI176592-02 type: NIH link: https://reporter.nih.gov/quickSearch/5UG3AI176592-02 briefTitle: Exploring, Predicting, and Intervening on Long-term Viral Suppression Electronically acronym: EPI-LoVE overallStatus: RECRUITING date: 2024-02-09 date: 2025-04-30 date: 2025-04-30 date: ... |
<|newrecord|> nctId: NCT06370767 id: 25634 briefTitle: Peer Facilitated Waitlist Controlled Transportation Study overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2025-05 date: 2024-04-17 date: 2024-04-17 name: Temple University class: OTHER briefSummary: The goal of this clinical trial is to test the... |
1. Individuals with SMI receiving either of the two peer-mediated travel training transportation interventions will experience an increase in transportation self-efficacy and transportation skills. |
2. Participants in the intervention arms will increase their transport utilization, participate in significantly more activities in the community, and make significantly more trips in the community. |
3. Individuals with SMI receiving peer-mediated travel training interventions will retain post-test levels of community participation and self-efficacy 2 months after intervention. |
Participants will be assigned to an 8-week travel-training intervention either using a bike-share program or public transportation. All participants will complete three data-collection research interviews. conditions: Serious Mental Illness studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: ... |
<|newrecord|> nctId: NCT06370754 id: 2401289-19-2403 briefTitle: Newly Emerging Immunotherapy for Pancreatic Cancer Treatment acronym: FD-IMPACT overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2026-04-30 date: 2027-04-30 date: 2024-04-17 date: 2024-04-17 name: Fudan University class: OTHER briefSummary: This i... |
<|newrecord|> nctId: NCT06370741 id: OkanUni. briefTitle: Effect of Stretching Exercises on Plantar Fascia overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-05 date: 2024-06 date: 2024-04-17 date: 2024-04-17 name: Okan University class: OTHER briefSummary: The plantar fascia (PF) extends over the calcaneal bon... |
Therefore, although the exact effect of stretching on the biomechanical properties of the plantar fascia is not known, it will be aimed to determine whether an instrument aid to be designed will have an effect and which method is more effective. In this way, it is planned to guide clinicians in the rehabilitation of po... |
Myotonometry is a convenient method to assess the stiffness of the plantar fascia because it is cheap, simple and fast. Previous studies have shown that MyotonPRO can reliably assess the stiffness of the plantar fascia. Although the exact effect of stretching on the biomechanical properties of the plantar fascia is not... |
<|newrecord|> nctId: NCT06370728 id: 18621 id: J2A-MC-GZPJ type: OTHER domain: Eli Lilly and Company briefTitle: A Drug-Drug Interaction (DDI) Study of Orforglipron With Carbamazepine in Healthy Participants overallStatus: NOT_YET_RECRUITING date: 2024-05-03 date: 2024-07-15 date: 2024-07-15 date: 2024-04-17 date: 2024... |
<|newrecord|> nctId: NCT06370715 id: 18269 id: I8B-MC-ITTA type: OTHER domain: Eli Lilly and Company briefTitle: A Study of LY900014 in Adult Participants With Type 2 Diabetes Mellitus in India overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-07 date: 2025-07 date: 2024-04-17 date: 2024-04-17 name: Eli Lilly ... |
The study will last about 33 weeks for each participant, including screening (1 week), Lead-in period (4 weeks), treatment period (26 weeks) and follow up period (2 weeks). conditions: Diabetes Mellitus, Type 2 studyType: INTERVENTIONAL phases: PHASE4 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREAT... |
<|newrecord|> nctId: NCT06370702 id: 23-054 briefTitle: Evaluating the Use of Grip Exercises to Decrease Deep Vein Thrombosis in Adult Patients With PICC Lines overallStatus: RECRUITING date: 2023-10-06 date: 2026-12-31 date: 2027-06-30 date: 2024-04-17 date: 2024-04-17 name: TriHealth Inc. class: OTHER briefSummary: P... |
<|newrecord|> nctId: NCT06370689 id: PRE-OX briefTitle: Comparison of Three Pre-oxygenation Strategies overallStatus: NOT_YET_RECRUITING date: 2024-05-23 date: 2024-12-31 date: 2025-07-30 date: 2024-04-17 date: 2024-04-17 name: Institute of Mountain Emergency Medicine class: OTHER briefSummary: Study objective: Compari... |
Study endpoints |
Primary Endpoint: |
The time taken from the start of preoxygenation until reaching an expiratory oxygen concentration (FeO2) of ≥ 90% or a maximum preoxygenation time of 3 min. |
Secondary endpoints: |
* Changes in regional ventilation within the posterior lung regions from baseline to the time when FeO2≥ 90% is achieved, assessed using electrical impedance tomography (EIT) |
* Difference in Oxygen Reserve Index (ORi) when FeO2≥ 90% is achieved |
Number of participants 15 participants per subgroup, i.e. 45 participants in total. |
Inclusion criteria |
* Normal-weight adults (body mass index, BMI 18.5-24.9 kg/m2) with an "American Society of Anesthesiologists Physical Status Classification System (ASA) " score of I or II |
* Adults with a BMI 25-39.9 kg/m2 with and ASA score \<3 |
* Healthy (ASA I) children aged 6-12 years Exclusion criteria ASA 3, Age \< 6 and age 12-18, pregnant women, missing informed consent, signs and symptoms of an acute respiratory illness on the study day. |
After informed consent and a medical check-up, baseline measurements will be done for 10 minutes (peripheral oxygen saturation SpO2, ORI, regional ventilation). Then the participants will undergo 3 different preoxygenation sessions with the 3 interfaces (i.e. non-rebreather facemask with reservoir and a bag-valve-mask ... |
<|newrecord|> nctId: NCT06370676 id: ESO-TIP briefTitle: Accuracy of Core Body Temperature Measurement Depending on Oesophageal Probe Tip Location acronym: ESO-TIP overallStatus: NOT_YET_RECRUITING date: 2024-05-23 date: 2024-12-31 date: 2025-07-30 date: 2024-04-17 date: 2024-04-17 name: Institute of Mountain Emergency... |
Hypothesis and aim The investigators hypothesise that an incorrect placement of the oesophageal temperature probe tip could lead to inaccurate measurements (i.e., temperature readings not reflecting the real CBT). Particularly, a tip location too high in the oesophagus in close proximity to the trachea could lead to fa... |
Methods Experimental, interventional study on 16 healthy volunteers. During the test oesophageal temperature is measured while participants are breathing ambient air first at 20°C (baseline) followed by cold (-20°C) ambient air in supine position for 20 minutes each test in an environmental simulator (terraXcube). Each... |
<|newrecord|> nctId: NCT06370663 id: SDZLEC2023-109-01 briefTitle: First-line Treatment for Unresectable Locally Advanced Distal Cholangiocarcinoma Combining Radiotherapy and HAIC overallStatus: RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-04-01 date: 2024-04-17 date: 2024-04-17 name: Shandong Cancer Hospita... |
<|newrecord|> nctId: NCT06370650 id: soh-med-24-1-9 briefTitle: Effect of Platelet Rich Plasma on Outcome of Narrow Band UVB in Treatment of Vitiligo; Clinical and Histopathological Study overallStatus: ACTIVE_NOT_RECRUITING date: 2023-12-08 date: 2024-01-25 date: 2024-06-30 date: 2024-04-17 date: 2024-04-17 name: Soha... |
<|newrecord|> nctId: NCT06370637 id: Survey Protocol briefTitle: Efficacy of Cream for Moisture Associated Skin Damage From Fecal Incontinence and/or Diarrhea acronym: Survey overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2026-05 date: 2024-04-17 date: 2024-04-17 name: Scotiaderm class: OTHER brief... |
<|newrecord|> nctId: NCT06370624 id: 2022/03OCT/360 briefTitle: PEDI-REAVASC Resonance Imaging of Infants With Hypoxic Ischemic Encephalopathy After Hypothermia Treatment. acronym: PEDI-REAVASC overallStatus: ACTIVE_NOT_RECRUITING date: 2023-01-17 date: 2025-09-15 date: 2025-10-01 date: 2024-04-17 date: 2024-04-17 name... |
The target population was neonates with HIE referred to MRI after hypothermia treatment, which was initiated within 6 hours of birth, continued for 72 hours and followed by a slow rewarming period of 6-12 hours. |
A one-year clinical and imaging follow-up is planned. As the aim of the present study is to assess the predictiveness of the outcome one year after the HIE event, no follow-up is planned. conditions: Encephalopathy, Hypoxic-Ischemic studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP int... |
<|newrecord|> nctId: NCT06370611 id: 2314027 briefTitle: Early Remote Rehabilitation to Improve Health of the Elderly After Cardiac Surgery. (RECARD Trial) acronym: RECARD overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-09-30 date: 2026-09-30 date: 2024-04-17 date: 2024-04-17 name: Ivy susanne Modrau, MD ... |
Eligible patients will be randomly assigned to either a control group receiving standard care or an intervention group, which will be introduced to an individually tailored exercise program as an addition to standard care. |
Follow-up is planned with an out-patient visit six weeks after discharge and a telephone interview six months post-surgery. |
All participants will undergo assessments at enrollment and during follow-up. Physical performance will be evaluated through physical tests. General well-being, quality of life, self-reported physical activity, and cost-effectiveness of the intervention will be assessed through questionnaires. Muscle health will be exa... |
The primary endpoint is the 30-second Chair Stand Test serving as a measurement of physical function. conditions: Cardiac Rehabilitation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Bi-center, prospective, randomized, controlled, parallel (1:1), t... |
<|newrecord|> nctId: NCT06370598 id: TP-122 briefTitle: Phase 1/2a to Assess the Safety and Tolerability of TP-122A for the Treatment of Ventilator-Associated Pneumonia acronym: RECOVER overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2025-05 date: 2025-06 date: 2024-04-17 date: 2024-04-17 name: Technophage, SA cl... |
<|newrecord|> nctId: NCT06370585 id: SOPH229-0823/I briefTitle: Clinical Study to Evaluate the Safety and Tolerability of PRO-229 Ophthalmic Solution Compared to Lagricel® Ofteno PF overallStatus: NOT_YET_RECRUITING date: 2024-05-30 date: 2024-09-30 date: 2024-09-30 date: 2024-04-17 date: 2024-04-17 name: Laboratorios ... |
<|newrecord|> nctId: NCT06370572 id: CIRB23-1162 id: U54AG063546 type: NIH link: https://reporter.nih.gov/quickSearch/U54AG063546 briefTitle: Pragmatic Use of PAIN-Advanced Dementia Scale in Emergency Departments overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-05 date: 2025-05 date: 2024-04-17 date: 2024-04-... |
<|newrecord|> nctId: NCT06370559 id: 339042 briefTitle: Relationship Between Repetitive Negative Thinking and CBT Outcomes overallStatus: COMPLETED date: 2022-01-01 date: 2024-02-01 date: 2024-02-01 date: 2024-04-17 date: 2024-04-17 name: South London and Maudsley NHS Foundation Trust class: OTHER briefSummary: The goa... |
The main questions it aims to answer are: |
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