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In a previous study \[Pubmed ID: 35609408\], the investigators demonstrated that NET also develops in NSCLCs without TKI targets or treatments. This phenomenon could be under-recognized, because re-biopsy was less frequently performed in these patients. The investigators had also shown that p53/Rb inactivation might co... |
In this study, the investigators proposed to prospectively follow up NSCLC patients with dual RB1/TP53 inactivation (approximately 5% of the total NSCLC). Through prospective and systematic collection of baseline pathological information, clinical treatment process, and imaging data, and as much as possible, repeat pat... |
<|newrecord|> nctId: NCT06369168 id: Kliniken Essen-Mitte briefTitle: Auricular Acupuncture and Hot Flashes During Adjuvant Endocrine Therapy acronym: OhrHit overallStatus: NOT_YET_RECRUITING date: 2024-05-20 date: 2024-11-20 date: 2025-11-20 date: 2024-04-16 date: 2024-04-23 name: Kliniken Essen-Mitte class: OTHER nam... |
Empirical studies indicate that body acupuncture has positive effects on hot flashes. As auricular acupuncture offers a number of advantages over body acupuncture, a three-armed randomised controlled research design is being used to investigate whether hot flashes caused by endocrine therapy are also reduced by ear acu... |
<|newrecord|> nctId: NCT06369155 id: 24-061 briefTitle: Azenosertib in Uterine Serous Carcinoma: Biomarker Study overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-01-31 date: 2027-01-31 date: 2024-04-16 date: 2024-04-16 name: Joyce Liu, MD class: OTHER name: National Cancer Institute (NCI) name: Zentalis brief... |
The name of the study drug involved in this study is: |
-Azenosertib (a type of Wee1 inhibitor) conditions: Uterine Serous Carcinoma conditions: Uterine Carcinoma conditions: Uterine Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 25 type: ESTIMATED name: Azenosertib measure: Perce... |
<|newrecord|> nctId: NCT06369142 id: GE IDE No. L00123 briefTitle: Intracoronary Stenting and Additional Results Achieved by ShockWAVE Coronary Lithotripsy acronym: ISAR-WAVE overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2027-04-30 date: 2027-07-31 date: 2024-04-16 date: 2024-04-16 name: Deutsches Herzzentru... |
<|newrecord|> nctId: NCT06369129 id: CEBD-CU-2024-06-16 briefTitle: Accuracy& Orbital Volume Using Patient Specific Titanium Implant Vs Zirconia for Orbital Floor Reconstruction overallStatus: RECRUITING date: 2024-04-06 date: 2025-08 date: 2025-08 date: 2024-04-16 date: 2024-04-17 name: Cairo University class: OTHER b... |
* Parallel group study. |
* A trial will be carried out in hospital of Oral and Maxillofacial surgery department - Faculty of Oral and Dental Medicine - Cairo University . |
* Equal randomization : participants with equal probabilities for intervention. |
* Positive controlled : Both groups receiving treatment. primaryPurpose: TREATMENT masking: NONE count: 20 type: ESTIMATED name: Orbital floor reconstruction with Patient Specific Zirconia Implant name: Orbital floor reconstruction with Patient Specific Titanium Implant measure: Orbital Volume measure: Accuracy of the ... |
<|newrecord|> nctId: NCT06369116 id: CLS-017B id: HSTAR012 type: OTHER domain: HSTAR Programme id: WRHI071 type: OTHER domain: Ezintsha briefTitle: Trial of Hepatitis C Self-Testing in the Hands of Untrained Lay Users overallStatus: RECRUITING date: 2023-10-12 date: 2023-11-17 date: 2024-04-22 date: 2024-04-16 date: 20... |
<|newrecord|> nctId: NCT06369103 id: FMBSUREC/03032024/Fakhry briefTitle: The Sedative Effects of Dexmedetomidine VS Propofol During Peribulbar Anesthesia in Patients Undergoing Vitrectomy Surgery overallStatus: RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-05-01 date: 2024-04-16 date: 2024-04-16 name: Beni-S... |
<|newrecord|> nctId: NCT06369090 id: JP/1/2013 briefTitle: Effect of Breast Size on the Electrical Impedance Tomography Measurement overallStatus: COMPLETED date: 2013-11-01 date: 2014-05-31 date: 2014-05-31 date: 2024-04-16 date: 2024-04-16 name: Czech Technical University in Prague class: OTHER briefSummary: Twenty-t... |
<|newrecord|> nctId: NCT06369077 id: CTGlaucoma1 briefTitle: How Much Does Reduced Dosing of Latanoprost and Dorzolamide-timolol Affect Pressure? overallStatus: RECRUITING date: 2024-04 date: 2024-07 date: 2024-07 date: 2024-04-16 date: 2024-04-17 name: CT Glaucoma Associates class: OTHER briefSummary: IOP effect of ha... |
At each study visit, dry eye signs will be assessed and brief dry eye survey will be administered. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Technician measuring IOP and assessing dry eye is masked regarding phase 2 and phase 3 crossover assignment order. whoMasked: OUTCOMES_ASSESSOR count: 60 type:... |
<|newrecord|> nctId: NCT06369064 id: 2023A02707-38 briefTitle: Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patient acronym: CompEER overallStatus: NOT_YET_RECRUITING date: 2024-06-15 date: 2026-08-15 date: 2026-08-15 date: 2024-04-16 date: 20... |
To our knowledge, there are no prospective studies comparing the efficiency of these two techniques with the same dose of dialysis (and the same filter). |
In the CompEER study, we aim to compare the efficiency of CVVHD and CVVHDF on urea reduction rate in intensive care patients with acute kidney injury. |
The research hypothesis is that CVVHD citrate technique is as effective as CVVHDF heparin technique for urea reduction and provides prolonged and stable clearance, facilitating antibiotic management during RRT. conditions: Acute Kidney Injury conditions: Continuous Renal Replacement Therapy conditions: Intensive Care U... |
<|newrecord|> nctId: NCT06369051 id: YSEmploy briefTitle: Supporting Self-employment in Young Adults With Stroke overallStatus: RECRUITING date: 2023-01-01 date: 2025-12-31 date: 2026-12-31 date: 2024-04-16 date: 2024-04-16 name: Chinese University of Hong Kong class: OTHER briefSummary: This project will investigate t... |
<|newrecord|> nctId: NCT06369038 id: CUP3222024 briefTitle: Children's Drawing as a Projective Tool to Assess Dental Anxiety overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2024-12-30 date: 2025-12-30 date: 2024-04-16 date: 2024-04-16 name: Cairo University class: OTHER briefSummary: The aim in this study is t... |
<|newrecord|> nctId: NCT06369025 id: PreVio briefTitle: Preventing Physical and Emotional Violence by Parents and Teachers in Public Schools in Tanzania (ICC-T/ICC-P_Tanz) acronym: PreVio overallStatus: RECRUITING date: 2024-04-15 date: 2025-02-28 date: 2025-07-30 date: 2024-04-16 date: 2024-04-17 name: Bielefeld Unive... |
One unique and novel aspect of this project is to test a school-based intervention approach that targets both teachers and parents. A school-based approach including both teachers and parents has the following key advantages: (1) parents of different social, economic, and educational backgrounds can be motivated to par... |
<|newrecord|> nctId: NCT06369012 id: Rania Gamal briefTitle: Management of Abnormal Uterine Bleeding overallStatus: RECRUITING date: 2024-03-01 date: 2024-09-01 date: 2024-09-30 date: 2024-04-16 date: 2024-04-16 name: Egymedicalpedia class: INDUSTRY briefSummary: Abnormal uterine bleeding "AUB" describes all abnormal f... |
<|newrecord|> nctId: NCT06368999 id: EEGCOV briefTitle: Neurophysiological and Neuropsychological Evalution in Healthcare Workers acronym: EEGCOV overallStatus: COMPLETED date: 2020-05-27 date: 2020-12-21 date: 2021-01-09 date: 2024-04-16 date: 2024-04-16 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico... |
<|newrecord|> nctId: NCT06368986 id: 222420 briefTitle: A Study to Investigate the Effect of Food on the Bioavailability of a Capsid Inhibitor (CAI) in Male and Female Healthy Participants overallStatus: NOT_YET_RECRUITING date: 2024-04-16 date: 2024-06-12 date: 2024-06-12 date: 2024-04-16 date: 2024-04-16 name: ViiV H... |
<|newrecord|> nctId: NCT06368973 id: RC16-4-2023 briefTitle: Mechanical Ventilation-Associated Complications and Co-Morbidities in Children Admitted in Pediatric Intensive Care Unit overallStatus: COMPLETED date: 2021-01-01 date: 2023-12-01 date: 2023-12-31 date: 2024-04-16 date: 2024-04-16 name: Benha University class... |
<|newrecord|> nctId: NCT06368960 id: BM201-1001 id: CTR20223162 type: REGISTRY domain: National Medical Products Administration briefTitle: BM201 in Combination With Radiotherapy in Patients With Advanced Solid Tumors acronym: BM201-1001 overallStatus: RECRUITING date: 2022-11-07 date: 2024-12-31 date: 2024-12-31 date:... |
<|newrecord|> nctId: NCT06368947 id: B.30.2.ATA.0.01.00/172 briefTitle: Therapeutic Play on Pain Tolerance and Emotion Regulation in Children overallStatus: RECRUITING date: 2024-03-29 date: 2024-12-29 date: 2026-12-29 date: 2024-04-16 date: 2024-04-17 name: Ataturk University class: OTHER briefSummary: The research is... |
<|newrecord|> nctId: NCT06368934 id: KY2024-011 briefTitle: Sub-lobectomy for IDH Wild-type and TERT Promoter Mutant Glioblastoma overallStatus: NOT_YET_RECRUITING date: 2024-04-08 date: 2026-12 date: 2027-06 date: 2024-04-16 date: 2024-04-16 name: Huashan Hospital class: OTHER briefSummary: Glioblastoma is recognized ... |
Interventions: the intervention group was to receive frontal, temporal, parietal, and occipital sub-lobotomies that met anatomical criteria, and the control group was to receive imaging total resection (T1-enhanced borders) that met the Response Assessment in Neuro-Oncology (RANO) criteria. |
Randomization The control group and intervention group were equal in size. Following intraoperative pathological diagnosis, participants were randomly assigned using a centralized randomization system known as the Interactive Web Response System (IWRS). Stratification factors included preoperative age brackets of \[18-... |
<|newrecord|> nctId: NCT06368921 id: VRT106-C01 briefTitle: A Study of Recombinant Oncolytic Virus M1(VRT106) in Patients With Solid Tumors overallStatus: RECRUITING date: 2024-04 date: 2025-09 date: 2025-12 date: 2024-04-16 date: 2024-04-16 name: Guangzhou Virotech Pharmaceutical Co., Ltd. class: INDUSTRY briefSummary... |
<|newrecord|> nctId: NCT06368908 id: 6I/2023/3 briefTitle: Transcutaneous Functional Magnetic Muscle Stimulation in Critically Ill acronym: FMS_ICU overallStatus: RECRUITING date: 2023-12-08 date: 2024-10-30 date: 2024-12-30 date: 2024-04-16 date: 2024-04-16 name: General and Teaching Hospital Celje class: OTHER briefS... |
Magnetic stimulation prevents inactivation atrophy of skeletal muscles, as demonstrated in the mobilized limb of rats. Transcutaneous magnetic stimulation of the quadriceps via the femoral nerve is a safe and painless method even when applied to humans. |
In patients with chronic obstructive pulmonary disease (COPD), quadriceps magnetic stimulation increased spontaneous contraction force compared to the control group and improved quality of life. Patients with COPD tolerate quadriceps magnetic stimulation well, as it does not affect oxidative stress in muscles but does ... |
In intensive care medicine, magnetic stimulation has been primarily used for diagnostic purposes in assessing diaphragm function, peripheral muscle strength assessment, and transcranial electrical stimulation as a diagnostic tool and therapeutic stimulation of brain cells. With the development of modern transcutaneous ... |
To date, no research has been conducted on the use and effectiveness of magnetic stimulation of peripheral muscles in critically ill individuals. |
The aim of the study is to investigate the effect of Functional Muscle Magnetic Stimulation (FMS) on the development of ICU-AW. conditions: Critical Illness Myopathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: One of legs is randomised to be stim... |
<|newrecord|> nctId: NCT06368895 id: 2188 briefTitle: Fecal Microbiota Transplantation by Oral Capsules for Hepatic Encephalopathy Treatment overallStatus: RECRUITING date: 2021-04-07 date: 2025-06 date: 2025-06 date: 2024-04-16 date: 2024-04-16 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: O... |
The aims of the study are: |
To evaluate the efficacy and safety of FMT by oral capsules in cirrhotic patients with hepatic encephalopathy refractory to standard therapy. |
To evaluate changes in the gut microbiota composition and in the intestinal and systemic inflammatory condition occurring after FMT and if they can be associated with clinical improvement. |
To evaluate metabolic modifications occurring after FMT and if they can be associated with clinical improvement. conditions: Hepatic Encephalopathy conditions: Dysbiosis studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 60 type: ES... |
<|newrecord|> nctId: NCT06368882 id: Yongping _Chen briefTitle: Efficacy and Safety of Antiviral Therapy With Peg-interferon for Chronic Hepatitis B Complicated With Nonalcoholic Fatty Liver Disease（OCEAN PROJECT） overallStatus: RECRUITING date: 2024-01-01 date: 2028-12-31 date: 2028-12-31 date: 2024-04-16 date: 2024-0... |
A total of 1500 patients with chronic hepatitis B complicated with nonalcoholic fatty liver disease are divided into test group (1000 patients receiving PEG-IFNα-based antiviral therapy (combined NAs or Peg-IFNα monotherapy) and control group（500 patients receiving NAs monotherapy） according to their treatment intentio... |
The primary efficacy indicator is HBsAg clearance at 48 weeks of treatment, and the secondary indicators included: (1) HBsAg clearance at 96 weeks of treatment, (2) Cumulative HBsAg clearance at week 24、120、144、168、192、216 and 240; (3) The improvement of liver function level(ALT, AST, TBIL, etc.), blood lipid (TC, TG, ... |
The security assessment includes adverse events, vital signs, and imaging. conditions: Nonalcoholic Fatty Liver Disease conditions: Chronic Hepatitis b studyType: INTERVENTIONAL phases: PHASE4 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 1500 type: ESTIMATED name... |
<|newrecord|> nctId: NCT06368869 id: #1/2022 briefTitle: The Effect of Different Types of Resin Cements on the Color Stability of Two Different Types of Ceramic Veneers overallStatus: COMPLETED date: 2023-01-10 date: 2024-01-20 date: 2024-01-20 date: 2024-04-16 date: 2024-04-16 name: amr elshimy class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06368856 id: 20CH024 id: 2020-006105-30 type: EUDRACT_NUMBER briefTitle: Pharmacology of Mupirocin in Nasal Application in Healthy Volunteers: Monocentric Study acronym: MUPIPHARM overallStatus: RECRUITING date: 2024-02-29 date: 2024-11 date: 2025-03 date: 2024-04-16 date: 2024-04-16 name: Centr... |
As a result, mupirocin is now widely used throughout the world, all the more so as, for reasons of ease of organization, many centers use this decolonization procedure universally (i.e. without prior screening for Staphylococcus aureus carriage), thus further increasing the use of this molecule. |
Mupirocin administration methods are very vague, ranging from 2 to 3 applications per day and the application of "a match head", i.e. 50 mg, to 500 mg per nostril. |
Mupirocin is bacteriostatic at low doses, becoming bactericidal at higher concentrations; low concentrations could favor the selection of resistance, so using the most effective dosage seems essential. This lack of precision in administration is linked to an almost complete ignorance of the pharmacokinetics of mupiroci... |
It therefore seems essential to conduct a pharmacokinetic study of this molecule, in order to eventually offer patients the regimen with the administration methods offering the best characteristics in terms of dosage and efficacy. conditions: Healthy conditions: Staphylococcus Aureus Infection studyType: INTERVENTIONAL... |
* first randomization - single dose part : 50mg or 500mg of mupirocin |
* wash-out: one month |
* second randomization - repeated doses part: 50mg mupirocin twice a day or 50 mg 3 times a day 500mg mupirocin twice a day or 500mg mupirocin 3 times a day primaryPurpose: OTHER masking: NONE count: 40 type: ESTIMATED name: Mupirocin (50 mg) name: Mupirocin (500 mg) name: blood samples after Single dose part name: nas... |
<|newrecord|> nctId: NCT06368843 id: Ketamine for POST briefTitle: the Impact of Ketamine Gargling on the Incidence of Post Intubation Sore Throat overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2024-08-15 date: 2024-09-20 date: 2024-04-16 date: 2024-04-16 name: Al-Azhar University class: OTHER briefSummary: T... |
<|newrecord|> nctId: NCT06368830 id: 2024-0337 id: A534100 type: OTHER domain: UW Madison id: Protocol Version 3/4/24 type: OTHER domain: UW Madison briefTitle: Oral and Swallowing Function in Older Adults overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2026-05 date: 2024-04-16 date: 2024-04-16 name... |
<|newrecord|> nctId: NCT06368817 id: ACNS2321 briefTitle: Chemotherapy Followed by Response-Based Reduced Radiation Therapy for Patients With Central Nervous System Germinomas overallStatus: NOT_YET_RECRUITING date: 2024-05-04 date: 2033-11-04 date: 2033-11-04 date: 2024-04-16 date: 2024-04-16 name: Children's Oncology... |
<|newrecord|> nctId: NCT06368804 id: ANTEIPA id: 2022-A01575-38 type: OTHER domain: ID-RCB briefTitle: Comparison of Two Antibiotic Regimens for the Treatment of Early Airways Infection With PA in Adults With Bronchiectasis acronym: ANTEIPA overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-11-01 date: 2028-... |
<|newrecord|> nctId: NCT06368791 id: 30001479 briefTitle: Anti-Stress Intervention Among Physicians Study acronym: ASIP overallStatus: RECRUITING date: 2024-04-15 date: 2024-06-30 date: 2024-10-30 date: 2024-04-16 date: 2024-04-26 name: Charite University, Berlin, Germany class: OTHER briefSummary: Medical practice oft... |
In this study, the effect of two quick stress-relief methods on daily stress levels is estimated. The two anti-stress exercises are designed to easily fit into daily routines: |
1. Box breathing (6 minutes) is known to reduce stress and lower the heart rate. It is used by the military and law enforcement, among others, to manage stress. |
2. Breathing and mindfulness exercise (10 minutes): This guided breathing and mindfulness intervention combines mindful breathing with simple body movements, developed to reduce the perceived level of stress. |
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