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* have operative samples stained by Congo red in search of amyloid, which will be typed by immunochemistry in positive samples, |
* undergo a multimodal imaging search for cardiac involvement, if ATTR is identified, |
* undergo a preoperative complete clinical examination, including collection of medical history, ECG, biochemical tests, and imaging (ultrasound scans of rotator cuff and hip capsule in all participating patients, of the carpal tunnel in patients operated at this site, and MRI + standing profile radiography of the l... |
* ATTR positive patients will be proposed to be followed-up by a reference center, with the aim of an early diagnosis of cardiac involvement, allowing efficient mamagement. |
Researchers will assess the frequency of ATTR deposits at each operated site, the frequency or ATTR cardiopathy in ATTR + patients, and will compare demographic, clinical, biochemical, and imaging features in patients with and without ATTR deposits, to guide the indications of pathological examination during these freq... |
<|newrecord|> nctId: NCT06367829 id: WO.24.025 briefTitle: Lubinus SPII Hip Stem Target Trial Emulation (LARGE) acronym: LARGE overallStatus: ENROLLING_BY_INVITATION date: 2024-01-08 date: 2024-07-14 date: 2025-01-08 date: 2024-04-16 date: 2024-04-16 name: JointResearch class: OTHER name: OLVG name: Uppsala University ... |
Primary research question: |
"Do primary total hip arthroplasties for patients with OA, hip fracture or osteonecrosis with the 150mm Lubinus SPII hip stem have better mortality and stem revision rates than primary total hip arthroplasties with the 130mm hip stem?" |
Secondary aims include: |
* How does line-to-line cementation, compare to undersized cementation in primary total hip arthroplasty for patients with OA, hip fracture, or osteonecrosis when comparing equal size Lubinus SPII hip stems implanted with different cementation techniques? |
* Does the Lubinus SPII 150mm hip stem perform equal to the Lubinus SPII 130mm hip stem in primary total hip arthroplasties for patients with OA, hip fracture or osteonecrosis when comparing patient reported outcome measures? |
To answer these questions, this study has been allowed use of registered data from the LROI (dutch arthroplasty registry) and the SAR (swedish arthroplasty registry). After exclusion of patients who did not meet inclusion criteria between 2007-2020, approximately 110000 patients remain eligible for analysis. conditions... |
<|newrecord|> nctId: NCT06367816 id: 13509 briefTitle: Brain Recovery With Automated VEntilation acronym: BRAVE overallStatus: RECRUITING date: 2024-04-11 date: 2024-12-31 date: 2024-12-31 date: 2024-04-16 date: 2024-04-16 name: University of Genova class: OTHER briefSummary: Thus far, the closed-loop ventilation mode ... |
<|newrecord|> nctId: NCT06367803 id: DVS010 briefTitle: Cost Analysis of Vascular Surgical Techniques overallStatus: COMPLETED date: 2023-06-01 date: 2023-12-01 date: 2024-03-01 date: 2024-04-16 date: 2024-04-16 name: University Hospital of Limerick class: OTHER briefSummary: Whilst mortality rates and surgical limitat... |
<|newrecord|> nctId: NCT06367790 id: Bask-Pliomet briefTitle: Plyometry and Tapping in the Functional Improvement of Non-professional Basketball Players overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-06-10 date: 2024-07-01 date: 2024-04-16 date: 2024-04-16 name: Universidad Católica San Antonio de Murcia... |
Objective. To analyse the efficacy of a physiotherapy intervention using a protocol of plyometric exercises and dry needling in non-professional basketball athletes. |
Methods. Randomised clinical study. 20 players will be randomised to an experimental group (plyometric exercises and dry needling of the gastrocnemius muscles) and a control group (plyometric exercises). The intervention will include 8 sessions over 4 weeks. The study variables will be: range of motion in dorsal flexio... |
Expected results. An intervention of plyometric exercises and dry needling produces significant differences in range of motion and vertical jump in basketball players, compared to the isolated administration of plyometric exercises. conditions: Basketball Players studyType: INTERVENTIONAL phases: NA allocation: RANDOMI... |
<|newrecord|> nctId: NCT06367777 id: 2024/14MAR/132 briefTitle: Cervical/Thoracic Neuromodulation and Nociceptive Processing acronym: MICROVOLT2 overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-10 date: 2024-10 date: 2024-04-16 date: 2024-04-16 name: Université Catholique de Louvain class: OTHER briefSummary:... |
<|newrecord|> nctId: NCT06367764 id: BPS-2022C3-30535 briefTitle: A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations acronym: LIFESCAPE overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-06 date: 2028-06 date: 2024-04-16 date: 2024-04-23 name: University of Califor... |
* Do these treatments reduce PTSD symptoms in LGBTQIA+ patients? |
* Do these treatments help improve quality of life and reduce depression in LGBTQIA+ patients? |
* Do stress from stigma and discrimination and drug/alcohol use change the impact of the treatment on PTSD symptoms? |
* Are LGBTQIA+ patients satisfied with these treatments? Do these treatments work differently among different groups within the LGBTQIA+ community? |
* Do LGBTQIA+ patients complete these treatments? |
Study participants will receive one of these two PTSD treatments. Participants will complete assessments before and after receiving treatment. conditions: PTSD studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR c... |
<|newrecord|> nctId: NCT06367751 id: 2024-00358; th23Kasenda briefTitle: Implementation of Liquid Biopsies During Routine Clinical Care in Patients With Advanced Malignancies (LIQPLAT) acronym: LIQPLAT overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-10 date: 2026-10 date: 2024-04-16 date: 2024-04-19 name: Un... |
Researchers will compare clinical and patient reported outcomes from the LIQPLAT study with patients who did not receive ctDNA measurements (external comparator from registry AO_2023-00091). |
Blood samples will be drawn from the patients as part of routine care and ctDNA measurements will be performed on these samples. conditions: Advanced Solid Tumor studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: This is a trial using routinely collected he... |
<|newrecord|> nctId: NCT06367738 id: 2024-11-14799 briefTitle: Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults overallStatus: NOT_YET_RECRUITING date: 2025-04-01 date: 2026-12-30 date: 2027-12-30 date: 2024-04-16 date: 2024-04-16 name: University of C... |
<|newrecord|> nctId: NCT06367725 id: 1-10-72-122-23 briefTitle: Pharmacokinetics of Dexamethasone in Childhood ALL and Reduction in Bone Mineral Density overallStatus: RECRUITING date: 2024-04-11 date: 2027-12-30 date: 2030-12-30 date: 2024-04-16 date: 2024-04-16 name: University of Aarhus class: OTHER briefSummary: Th... |
* How does the intake of dexamethasone correlate with systemic exposure to dexamethason? |
* Does systemic exposure to dexamethasone correlate with a reduction in bone mineral density? |
Participants will: |
* Continue to receive the best available therapy for ALL in Western Europe. |
* Have blood samples taken from their central line to measure dexamethasone levels. |
* When standard lumbar punctures are done as part of treatment, a sample of cerebrospinal fluid will also be taken to analyze dexamethasone. |
* Visit the clinic four times for a DXA scans to measure bone density and vertebral fracture assessment: within three weeks of starting treatment, six months after starting treatment, one month after finishing treatment, and one year after finishing treatment. Biomarkers related to bone health will also be collected on... |
<|newrecord|> nctId: NCT06367712 id: Ahmed Kassab briefTitle: Letrozole Alone Protocol Versus Using Letrozole and HCG Protocol overallStatus: COMPLETED date: 2022-11-10 date: 2023-11-01 date: 2023-11-10 date: 2024-04-16 date: 2024-04-16 name: Egymedicalpedia class: INDUSTRY briefSummary: Letrozole is a chemical compoun... |
Letrozole blocks estrogen synthesis by directly affecting the hypothalamic-pituitary-ovarian axis, subsequently, increases gonadotropins which increase pregnancy rates. Possible positive outcomes of aromatase inhibitors over selective estrogen-receptor modulators include a more physiologic hormonal stimulation of the e... |
<|newrecord|> nctId: NCT06367699 id: H-44821 briefTitle: Conversational Agents to Improve HPV Vaccine Acceptance in Primary Care (ECA-HPV) Clinical Trial overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-09 date: 2027-12 date: 2024-04-16 date: 2024-04-16 name: Tufts Medical Center class: OTHER name: Boston Med... |
<|newrecord|> nctId: NCT06367686 id: REK KULMU B 714179 briefTitle: Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor acronym: DISCO overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-12 date: 2024-12 date: 2024-04-16 date: 2024-04-16 name: The Hospital of Vestfold class: OTHER name: Sensocure AS ... |
<|newrecord|> nctId: NCT06367673 id: QH-ZYDC-01 briefTitle: Natural Killer(NK) Cell Therapy Targeting CLL1 or CD33 in Acute Myeloid Leukemia overallStatus: RECRUITING date: 2024-04-30 date: 2026-03-31 date: 2026-08-31 date: 2024-04-16 date: 2024-04-18 name: Zhejiang University class: OTHER name: Hangzhou Qihanjiyin Bio... |
<|newrecord|> nctId: NCT06367660 id: 98-2024 briefTitle: Comparison Between Hyperbaric Bupivacaine With Fentanyl vs. Hyperbaric Bupivacaine With Dexmedetomidine in Reducing Visceral Pain During Cesarean Delivery Under Spinal Anaesthesia overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-08 date: 2024-09 date: 2... |
<|newrecord|> nctId: NCT06367647 id: zhujiangjy-20240229 briefTitle: Investigation on the Detection Rate of Pathogenic Viruses in Feces of Parenteral Infected Individuals overallStatus: RECRUITING date: 2024-04-15 date: 2025-10-31 date: 2025-12-31 date: 2024-04-16 date: 2024-04-22 name: Zhujiang Hospital class: OTHER b... |
<|newrecord|> nctId: NCT06367634 id: TEO-TSUL-2301 briefTitle: TEOSYAL® PureSense ULTRA DEEP Versus Restylane® Lidocaine for the Correction of Moderate to Severe Nasolabial Folds in Chinese Adults overallStatus: RECRUITING date: 2024-01-19 date: 2025-01 date: 2026-02 date: 2024-04-16 date: 2024-04-16 name: Teoxane SA c... |
Eligible subjects will be enrolled and randomized either to the treatment group or control group in a 1:1 ratio on Day 0. Each subject assigned to the treatment group will receive TEOSYAL® PureSense ULTRA DEEP in both NLFs, whereas subjects assigned to the control group will receive Restylane® Lidocaine. |
The treating investigator will administer the corresponding product in both NLFs of the subject on Day 0. |
All subjects will return to the site at 4, 12, 24, 36, and 52 weeks after the last treatment for effectiveness and safety assessment. All subjects will receive a safety phone call 7 days after the initial treatment at baseline, and after the touch-up treatment, if applicable. conditions: Nasolabial Folds studyType: INT... |
<|newrecord|> nctId: NCT06367621 id: CLS-015C briefTitle: Retrospective Study of iStatis Syphilis Ab Test (POC) overallStatus: ACTIVE_NOT_RECRUITING date: 2023-11-15 date: 2024-04-15 date: 2024-04-15 date: 2024-04-16 date: 2024-04-16 name: bioLytical Laboratories class: INDUSTRY briefSummary: The purpose of this retros... |
<|newrecord|> nctId: NCT06367608 id: HP-00104695 briefTitle: MRgFUS Pallidotomy for the Treatment of Task Specific Focal Hand Dystonia (TSFD) acronym: FUS Dystonia overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-06 date: 2028-06 date: 2024-04-16 date: 2024-04-25 name: University of Maryland, Baltimore class:... |
<|newrecord|> nctId: NCT06367595 id: Intrathecal MgSO4 briefTitle: Effect of Intrathecal Magnesium Sulfate Versus Intravenous Magnesium Sulfate on Postoperative Pain After Abdominal Hysterectomy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-10 date: 2026-11 date: 2024-04-16 date: 2024-04-16 name: Assiut Un... |
<|newrecord|> nctId: NCT06367582 id: CV01-TK-SPINE briefTitle: SPINE BONE CEMENTS OUTCOMES overallStatus: RECRUITING date: 2019-09-04 date: 2029-09-04 date: 2039-09-30 date: 2024-04-16 date: 2024-04-16 name: Teknimed class: INDUSTRY briefSummary: A Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on... |
TEKNIMED bone cements are legacy products, some marketed for more than 10 years. Their performance and safety have already been demonstrated by Post-Market Surveillance and previous clinical studies. The current Post-Market Clinical Follow-Up study aims to confirm these claims by collecting data in a "real-life" settin... |
The study is a retrospective and prospective global, single arm, non-controlled, multicentric, prospective observational study. Patients will be followed as per local standard medical care of the sites. conditions: Vertebral Fracture conditions: Compression Fracture conditions: Osteoporotic Fractures studyType: OBSERVA... |
<|newrecord|> nctId: NCT06367569 id: 2012//375 briefTitle: Evaluation of MRI of the Pineal Gland in Retinoblastoma acronym: TRbFU overallStatus: COMPLETED date: 2012-10-01 date: 2023-09-01 date: 2023-09-01 date: 2024-04-16 date: 2024-04-16 name: Amsterdam UMC, location VUmc class: OTHER briefSummary: Rationale: Current... |
Objective: The main objective of this prospective multicenter study is to evaluate the current strategy of baseline MRI screening of the brain in newly diagnosed retinoblastoma patients, with extended follow-up of selected patients with simple and complicated pineal cysts. |
Study design: The investigators propose a prospective cohort study (part of a larger multicenter study) to investigate the diagnostic accuracy and survival of baseline MRI screening of the pineal gland in new patients with retinoblastoma, with extended follow-up of selected patients with pineal cysts for early detectio... |
Study population: Within the European Retinoblastoma Imaging Collaboration (ERIC) about 150 new retinoblastoma patients are diagnosed every year. About 10 percent of all new retinoblastoma patients will be diagnosed at the VUmc. According to our sample size calculations the investigators will need 334 Rb patients. |
Main study parameters/endpoints: The primary endpoint of the study is pineoblastoma or supra- / parasellar PNET on MRI (index test). Because a gold standard will not be available, tumor cells in cerebrospinal fluid, histopathological confirmation, clinical disease progression during follow-up, and/or follow-up MRI diag... |
<|newrecord|> nctId: NCT06367556 id: 4542 briefTitle: Emotion and Symptom-Focused Engagement (EASE) for Caregivers acronym: EASE overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2027-10-01 date: 2028-10-01 date: 2024-04-16 date: 2024-04-16 name: University Health Network, Toronto class: OTHER name: The Hospital... |
- Does EASE reduce traumatic stress symptom severity (primary outcome)? |
To do so, researchers will compare parents receiving EASE to usual care. Participants in both groups will complete questionnaires package at enrolment, and 4, 8, and 12 weeks, and 6 months after enrolment. They will also be invited to participate in optional qualitative interviews to better understand their experience.... |
<|newrecord|> nctId: NCT06367543 id: AZ 117/22 briefTitle: Guideline-recommended Basic Parameter Adherence in Neurocritical Care Patients acronym: NORMONICU overallStatus: ACTIVE_NOT_RECRUITING date: 2022-11-30 date: 2024-02-29 date: 2024-12-31 date: 2024-04-16 date: 2024-04-16 name: University of Giessen class: OTHER ... |
<|newrecord|> nctId: NCT06367530 id: GS-TRIO-2024 briefTitle: Trilateral Retinoblastoma: Incidence and Outcomes acronym: GS-TRIO overallStatus: RECRUITING date: 2024-01-01 date: 2027-12-31 date: 2029-12-31 date: 2024-04-16 date: 2024-04-16 name: Amsterdam UMC, location VUmc class: OTHER briefSummary: Patients with heri... |
<|newrecord|> nctId: NCT06367517 id: KB/114/2022 briefTitle: Tocilizumab in Corticosteroid-Resistant Graves' Orbitopathy (Thyroid Eye Disease) overallStatus: RECRUITING date: 2021-05-20 date: 2025-05-20 date: 2026-05-20 date: 2024-04-16 date: 2024-04-16 name: Medical University of Warsaw class: OTHER briefSummary: The ... |
<|newrecord|> nctId: NCT06367504 id: DB/230904/DBMF/CDI briefTitle: A Study to Assess the Effect of Doctor's Biome Medical Food in Individuals With Clostridium Difficile Infection overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-15 date: 2024-12-30 date: 2024-04-16 date: 2024-04-16 name: Vedic Lifescien... |
<|newrecord|> nctId: NCT06367491 id: IRST100.12 briefTitle: National Database of Bone Metastases acronym: BDMO overallStatus: RECRUITING date: 2013-10-08 date: 2030-01-01 date: 2030-01-01 date: 2024-04-16 date: 2024-04-16 name: Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori class: OTHER briefSummary:... |
<|newrecord|> nctId: NCT06367478 id: SPEMG briefTitle: Evaluation of Nerve Conduction Study acronym: SPEMG overallStatus: ACTIVE_NOT_RECRUITING date: 2021-08-01 date: 2021-10-22 date: 2024-10-22 date: 2024-04-16 date: 2024-04-16 name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico class: OTHER briefSummary:... |
<|newrecord|> nctId: NCT06367465 id: 202308056 briefTitle: Feasibility and Acceptability of HCV Treatment in Pregnancy overallStatus: RECRUITING date: 2024-02-01 date: 2026-02-28 date: 2026-02-28 date: 2024-04-16 date: 2024-04-16 name: Washington University School of Medicine class: OTHER briefSummary: Pregnant adults ... |
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