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What does the study do? |
It collects information on Italian patients with Familial Hypercholesterolaemia (FH), following them in their normal clinical examination without adding extra procedures. |
It uses the data collected to further our understanding of diseases such as familial hypercholesterolaemia, examining how it is diagnosed clinically and by genetic testing, and evaluating the effectiveness of different treatments. |
It seeks to identify the genetic mutations that cause familial hypercholesterolaemia and other dyslipidaemias, helping to choose the most effective treatments. |
It evaluates the impact of long-term treatments and patient adherence to medication, as well as monitoring the incidence of cardiovascular events and other important outcomes. |
Who can participate? |
The study is aimed at people of all ages, from children to adults, with familial hypercholesterolaemia or other genetic dyslipidaemia. |
More than 50 centres throughout Italy are involved, making the study accessible to many. |
What does participation entail? |
Participants will continue with their normal clinical practice. |
Data such as family history, personal clinical findings and genetic information will be collected, without additional procedures. |
For some, further evaluations, such as ultrasounds, may be required to better study their condition. |
The LIPIGEN study not only helps to better understand diseases related to high cholesterol but also aims to improve patients\' lives through more precise diagnosis and personalised treatments. conditions: Familial Hypercholesterolemia conditions: Genetic Disorder studyType: OBSERVATIONAL observationalModel: COHORT ... |
<|newrecord|> nctId: NCT06362460 id: RAY1216-23-03 briefTitle: Mass Balance Study of [14C]RAY1216 in Healthy Adult Male Subjects in China overallStatus: COMPLETED date: 2023-09-18 date: 2023-11-01 date: 2023-11-15 date: 2024-04-12 date: 2024-04-16 name: Guangdong Raynovent Biotech Co., Ltd class: INDUSTRY briefSummary:... |
<|newrecord|> nctId: NCT06362447 id: RC31/22/0320 briefTitle: Efficacy of Injectable Gentamicin in Hereditary Ichthyosis acronym: GENTIC overallStatus: NOT_YET_RECRUITING date: 2024-04-23 date: 2026-04-01 date: 2027-04-01 date: 2024-04-12 date: 2024-04-12 name: University Hospital, Toulouse class: OTHER briefSummary: T... |
<|newrecord|> nctId: NCT06362434 id: UHN-HHREHAB-24-xxxx briefTitle: Visual Telerehabilitation in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour acronym: HHREHAB overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2027-06-01 date: 2027-06-01 date: 2024-04-12 date: 2024-04-12 ... |
Our laboratory has developed a visual rehabilitation procedure based on the combination of adaptative audio and visual target tracking in a 3D environment in virtual reality. Participants perform audiovisual stimulation at home in a headset, with remote control from the laboratory. Preliminary on data on paediatric pat... |
Our objective is to evaluate the effectiveness of Re:Vision, an 8-week visual telerehabilitation program, on visual perception in 50 individuals aged 10-40 years old with hemianopia consecutive to a pediatric brain tumor in a phase IIa/b multi-centric clinical study across Canada. |
This intervention provides more equitable access to individuals, with the ability to receive rehabilitation therapy at home without supervision by a healthcare professional, meaning that Canadians living outside urban centres could take advantage of specialized therapies with remote supervision. This is the first study... |
<|newrecord|> nctId: NCT06362421 id: ONC-HN-2402 briefTitle: Saliva Testing for High-Risk Human Papillomavirus Infection Oral Cavity and Pharynx Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-06 date: 2026-07 date: 2024-04-12 date: 2024-04-12 name: Wake Forest University Health Sciences class: OTHER ... |
<|newrecord|> nctId: NCT06362408 id: PLAGH-DEX-PSM/IPTW-001 briefTitle: Effect of Dexmedetomidine on Postoperative Mental Disorders and Long-term Survival in Elderly Patients overallStatus: COMPLETED date: 2022-06-01 date: 2023-05-25 date: 2023-06-01 date: 2024-04-12 date: 2024-04-12 name: Chinese PLA General Hospital ... |
Dexmedetomidine (DEX) is an alpha-2 adrenergic agonist that works by inhibiting norepinephrine releasing renaline, which reduces inflammation and thus plays a protective role in the central nervous system. DEX has the potential to prevent and treat postoperative anxiety and depression in elderly patients undergoing non... |
Further exploration of evidence for evidence-based medicine is needed. Based on the above research background, this hypothesis is proposed: in elderly patients undergoing noncardiac surgery, intraoperative DEX is associated with a reduction in short-term postoperative mental disorders and a reduction in long-term posto... |
<|newrecord|> nctId: NCT06362395 id: 24-5022 briefTitle: Ultra-high Dose Radiation for Liver Metastasis Using MR-guided TReatment With Stereotactic Ablative Single-fraction acronym: ULTRAS overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2030-06 date: 2030-06 date: 2024-04-12 date: 2024-04-12 name: University Heal... |
Liver metastases are common in several cancers, but surgery is often not feasible for many patients. Stereotactic body radiotherapy (SBRT), which delivers focused radiation to tumors, is an alternative treatment option. Previous studies have shown promising results with SBRT, but the optimal radiation dose for liver me... |
This study will look at patients with specific types of primary cancers known to respond well to SBRT. Treatment effectiveness will be assessed by monitoring tumor control, overall survival, and quality of life. |
By comparing ultra-high dose SBRT with standard high dose, the study aims to determine if the former can provide better tumor control with fewer side effects. If successful, this approach could offer a significant advancement in the treatment of liver metastases, potentially improving outcomes and quality of life for p... |
<|newrecord|> nctId: NCT06362382 id: 2024-zxm-01 briefTitle: Mobile Internet-based Remote Home Rehabilitation Improves Prognostic Function and Life Quality in Pulmonary Hypertension overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2026-04-22 date: 2026-05-01 date: 2024-04-12 date: 2024-04-12 name: China-Japan F... |
Dose tele-rehabilitation training improves prognostic function and quality of life in patients with pulmonary hypertension？ Researchers will compare tele-rehabilitation training group to a control group (receive health propaganda and education, and then follow their daily routine after discharge from the hospital) to s... |
Participants will: |
During their stay in the hospital, the patients of tele-rehabilitation training group were accompanied by a rehabilitation trainer and a psychotherapist for a complete cycle of (7 days ± 3 days 1 week/times) standardized training. The scheme of rehabilitation is impedance training. A specialized professional team inclu... |
Visit the clinic at the 3rd month of the study. Extended follow-up up to 6 months may be considered if patients are cooperative and could complete the training program in the first 3 months. conditions: Pulmonary Hypertension studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primar... |
<|newrecord|> nctId: NCT06362369 id: 7HP-111 briefTitle: A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2027-12-31 date: 2028-12-31 date: 2024-04-12 date: 2024-04-12 name: 7 Hills Pharma, LLC class: INDUSTRY ... |
Currently study will only be enrolling the Phase 1b and the Phase 2a protocol requirements will be added to the study near completion of the Phase 1b conditions: Advanced Cancer conditions: Advanced Solid Tumor conditions: Melanoma conditions: Metastasis conditions: Pleural Mesothelioma conditions: Renal Cell Carcinoma... |
<|newrecord|> nctId: NCT06362356 id: 24-106 briefTitle: Microbial Metabolites and Outcomes of Pregnancy Study acronym: MMOPS overallStatus: RECRUITING date: 2024-03-05 date: 2026-12-31 date: 2026-12-31 date: 2024-04-12 date: 2024-04-18 name: The Cleveland Clinic class: OTHER briefSummary: Emerging data connect diet, th... |
Despite high biological plausibility that nutrition, the gut microbiota and its metabolites may play a role in health and disease in pregnancy, there is a paucity of data regarding these associations, thus limiting advancement of the field. Similar to the proposed pathogenesis for diet, gut microbiota and the microbial... |
Through 1) characterizing plasma and urine TMAO levels across each trimester of pregnancy, and 2) assessment of this microbial metabolite as a predictor of development of HDP, we have the potential to identify a biomarker that would allow us to identify people at risk of HDP early in pregnancy and provide new opportuni... |
<|newrecord|> nctId: NCT06362343 id: PUMCH-Rivaroxaban-Monitoring briefTitle: The Study of Monitoring and Dosing Guidance of Direct Oral Anticoagulants Based on Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics overallStatus: RECRUITING date: 2024-01-01 date: 2026-10-30 date: 2027-01-30 date: 2024-04-12 date: 20... |
2. Investigate the factors influencing PK-PD of DOACs in the pulmonary embolism population, clarifying the correlation between genotype characteristics and clinical outcomes. |
3. Explore the correlation between drug concentrations, coagulation indices, and clinical outcomes of DOACs, defining the indications for DOACs testing and the overall monitoring process. conditions: Pulmonary Embolism studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 300 type: EST... |
<|newrecord|> nctId: NCT06362330 id: 2022-SR-471 briefTitle: Multi-parametric MRI in Patients of Bladder Cancer overallStatus: RECRUITING date: 2021-07-01 date: 2024-05-30 date: 2024-06-30 date: 2024-04-12 date: 2024-04-12 name: The First Affiliated Hospital with Nanjing Medical University class: OTHER briefSummary: Ac... |
<|newrecord|> nctId: NCT06362317 id: K5247 briefTitle: Toripalimab With or Without Lenvatinib or Chemotherapy in First-Line Treatment of Advanced Biliary Tract Cancer overallStatus: RECRUITING date: 2024-03-06 date: 2025-03-06 date: 2026-03-06 date: 2024-04-12 date: 2024-04-12 name: Peking Union Medical College Hospita... |
<|newrecord|> nctId: NCT06362304 id: 2024-DG-01 briefTitle: 99mTc-CNDG SPECT/CT in Brain Tumors overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-02 date: 2025-04 date: 2024-04-12 date: 2024-04-12 name: Peking Union Medical College Hospital class: OTHER briefSummary: The goal of this clinical trial is to evalu... |
1. What is the diagnostic consistency between 99mTc-CNDG and 18F-FDG? |
2. What is the correlation between the SUVmax value of 99mTc-CNDG and tumor type? |
Participants will: |
Receive18F-FDG-PET and 99mTc-CNDG examination within 2 weeks before surgery. Obtain pathological diagnosis by surgery or biopsy as the gold standard. conditions: Intracranial Tumor studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOSTIC masking: NONE count: 30 type... |
<|newrecord|> nctId: NCT06362291 id: 2023IR27 briefTitle: Comparison of MRI AI-cTB Versus Routine cTB in Prostate Cancer Diagnosis: a Prospective Randomized Controlled Trial overallStatus: RECRUITING date: 2023-08-01 date: 2024-07-31 date: 2025-04-30 date: 2024-04-12 date: 2024-04-12 name: Peking University First Hospi... |
Does AI-cTB promote the accurate diagnosis and treatment of prostate cancer? What's the value of prostate MRI artificial intelligence assistant diagnosis system in developing the best scheme of prostate biopsy? What's the value of prostate MRI artificial intelligence assistant diagnosis system in predicting the patholo... |
Researchers will compare the cancer detection rates of AI-cTB and routine cTB to explore the added value of using AI for the guidance of cTB. |
Participants will: |
Receive AI-cTB or routine cTB. conditions: Prostate Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: DIAGNOSTIC masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 340 type: ESTIMATED name: MRI-AI guided cognitive prostate targeted biopsy name: Routine cogni... |
<|newrecord|> nctId: NCT06362278 id: 026 briefTitle: A Multi-omics Study of "Healthy" Premature CAD Patients overallStatus: RECRUITING date: 2024-03-20 date: 2025-12 date: 2025-12 date: 2024-04-12 date: 2024-04-12 name: The First Affiliated Hospital with Nanjing Medical University class: OTHER briefSummary: The goal of... |
The main questions it aims to answer are: |
* Genetic risk factors \& metabolic fingerprints of patients with premature CAD and none traditional CAD risk factors remain unknown. |
* How to optimize current primary prevention strategy for this rare CAD subgroup？ conditions: Coronary Artery Disease studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 160 type: ESTIMATED name: multi-omics studies measure: common & rare variants associated with "healthy" pr... |
<|newrecord|> nctId: NCT06362265 id: 18437 id: I8H-MC-BDDB type: OTHER domain: Eli Lilly and Company briefTitle: A Study to Evaluate Pharmacokinetics of LY3209590 in Pediatric Participants With Type 2 Diabetes Mellitus overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-11 date: 2026-11 date: 2024-04-12 date: 20... |
<|newrecord|> nctId: NCT06362252 id: DS7300-189 id: 2023-509629-36 type: OTHER domain: EU CT briefTitle: A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03) overallStatus: NOT_YET_REC... |
<|newrecord|> nctId: NCT06362239 id: STUDY00003853 briefTitle: Prospective Home-Based Palliative Care and Hospice Study overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-10 date: 2027-10 date: 2024-04-12 date: 2024-04-12 name: Steven Smith class: OTHER name: Akron Children's Hospital name: Medical University o... |
<|newrecord|> nctId: NCT06362226 id: HM20029491 briefTitle: OPTIMIZING OCULAR OUTCOMES: A DUAL-ARMED STUDY FOR PERIORBITAL BURN MANAGEMENT overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-08 date: 2026-10 date: 2024-04-12 date: 2024-04-12 name: Virginia Commonwealth University class: OTHER briefSummary: The p... |
<|newrecord|> nctId: NCT06362213 id: NL76924.029.22 briefTitle: Gaining Insight Into Dual Sensory Loss acronym: DSL overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-04 date: 2025-04 date: 2024-04-12 date: 2024-04-12 name: Amsterdam UMC, location VUmc class: OTHER name: Royal Dutch Visio briefSummary: The g... |
• What influence do varying severities of vision and hearing loss have on information access, mobility, communication and fatigue. |
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