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<|newrecord|> nctId: NCT06355713 id: 69HCL23_0899 id: 2023-A02010-45 type: OTHER domain: ID-RCB briefTitle: Improvement of Symptoms After Removal of the Essure® Contraceptive Implant acronym: ABLES overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2031-08-01 date: 2036-06-01 date: 2024-04-09 date: 2024-04-09 nam... |
The physiopathological mechanism(s) is (are) not yet determined but several arguments are in favor of a dissemination of metallic elements contained in these implants whose accumulation could lead to inflammatory and/or allergic and/or autoimmune phenomena. |
Carrying out a prospective study with long-term longitudinal follow-up appears essential to precisely assess the degree of improvement in the symptoms and quality of life of these patients, determine the most appropriate surgical techniques, and understand the pathophysiological mechanisms that may result in the implem... |
<|newrecord|> nctId: NCT06355700 id: 5476 briefTitle: Hepatocellular Carcinoma Liver Organoids acronym: HELIO overallStatus: RECRUITING date: 2023-06-15 date: 2025-03 date: 2025-03 date: 2024-04-09 date: 2024-04-09 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: The goal of ... |
* the feasibility of hepatocellular carcinoma organoids integrated with host gut microbiota and peripheral blood mononuclear cells |
* the molecular pattern of the organoid tumor microenvironment |
* the in vitro therapeutic response of hepatocellular carcinoma organoids conditions: Hepatocellular Carcinoma studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: OTHER masking: NONE count: 10 type: ESTIMATED name: Liver biopsy measure: Success rate of hepatocellular carc... |
<|newrecord|> nctId: NCT06355687 id: FMASU MD304/2023 briefTitle: Melatonin in Obese Patients in Laparoscopic Cholecystectomy overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-09 date: 2024-04-09 name: Ain Shams University class: OTHER briefSummary: Opioid free anesthesia (OFA) m... |
<|newrecord|> nctId: NCT06355674 id: HRÜ/23.21.12 briefTitle: Adolescent Mother and Breastfeeding Education overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-09-15 date: 2024-10-15 date: 2024-04-09 date: 2024-04-09 name: Adiyaman University class: OTHER briefSummary: In low-income and developing countries, ... |
In pregnancies occurring during adolescence, both maternal and infant mortality rates are two to three times higher compared to pregnancies at later ages. Many infant and child deaths occur due to preventable causes. Breastfeeding is a significant factor in reducing infant and child mortality. Since infants born to ado... |
<|newrecord|> nctId: NCT06355661 id: HP/231102/PA/URTI briefTitle: A Study for Assessing the Efficacy and Safety ParActin® in Individuals With Upper Respiratory Tract Infections overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-05-15 date: 2024-06-01 date: 2024-04-09 date: 2024-04-09 name: Vedic Lifescience... |
<|newrecord|> nctId: NCT06355648 id: IRAS 337181 briefTitle: Advanced Clinical Practitioners in the ED overallStatus: NOT_YET_RECRUITING date: 2024-05-03 date: 2024-10-01 date: 2025-03-01 date: 2024-04-09 date: 2024-04-09 name: King's College London class: OTHER briefSummary: No patient data is involved in the study. T... |
1) What is the EC-ACP's perception of assimilation into emergency care teams, what tensions are created due to the role, and what system adaptations are required to facilitate integration? |
With secondary aims : |
1. What are the common organisational factors that affect the implementation of the EC-ACP workforce, and what recommendations can be made to improve Trust-wide implementation? |
2. How are EC-ACPs deployed in two contrasting emergency departments, what differences can be identified in their Work-As-Done (WAD), and how does this compare to the Work-As-Imagined (WAI) of the role? |
Participants will all be staff members who work in the hospital. Patient data is not being collected or processed. This is a mixed-method study using two approaches to collect data: |
1. Observation of the EC-ACPs at work - noting how they interact with colleagues and how they are deployed in the ED. |
2. Interviews with various staff who work with the EC-ACPs clinically or in various managerial or director roles. |
Background |
In the UK, a health care role has been developed called Advanced Clinical Practitioners (ACPs). ACPs work in various clinical settings, but this study focuses on those in Emergency Care. While non-medical practitioners have worked in Emergency Departments (EDs) for over 20 years, the ACP role is relatively new. Most AC... |
These roles were heavily supported by local and political desires to create blended workforces to meet increasing patient demands. The problem with implementing ACP roles is that initially, little consultation was held with stakeholders in EDs. This has resulted in various trade-offs. For example, trainee doctors often... |
Previous research on advanced roles in ED has focused on direct clinical comparisons between doctors and practitioners. Researchers have investigated which professional (doctors vs. nurse practitioners) triages patients quickest or who is more accurate at interpreting X-rays. There are several problems with these appro... |
<|newrecord|> nctId: NCT06355635 id: JohannesGUVA briefTitle: Application and Monitoring of Vasoactive and Inotrope Drugs acronym: Vasin overallStatus: RECRUITING date: 2024-04-04 date: 2024-06-01 date: 2024-11-01 date: 2024-04-09 date: 2024-04-09 name: Johannes Gutenberg University Mainz class: OTHER briefSummary: The... |
<|newrecord|> nctId: NCT06355622 id: 3717 briefTitle: Prevalence and Characterization of Pain in RASopathies acronym: 3717 overallStatus: RECRUITING date: 2021-01-27 date: 2024-01-30 date: 2024-06-30 date: 2024-04-09 date: 2024-04-09 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSu... |
<|newrecord|> nctId: NCT06355609 id: DZ2023EI004-RW briefTitle: Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR Mutant Advanced NSCLC-RW acronym: WUKONG-32-RW overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2025-12-30 date: 2027-12-30 date: 2024-04-09 date: 2024-04-09 name: Hunan Province Tumor Hospital c... |
<|newrecord|> nctId: NCT06355596 id: 20IC6361 briefTitle: Development and Validation of a Virtual Teaching Method for Minimally Invasive Surgery Skills overallStatus: COMPLETED date: 2022-03-11 date: 2022-04-08 date: 2022-04-08 date: 2024-04-09 date: 2024-04-09 name: Imperial College London class: OTHER briefSummary: T... |
Can MIS skills be effectively taught to novice learners through a virtual platform using widely available technology? How do virtual and face-to-face (F2F) teaching methods compare in terms of effectiveness, measured by performance in MIS tasks and cognitive workload parameters? |
Participants in this study will: |
Be randomly allocated to either F2F or virtual teaching groups. Undergo training and evaluation using validated laparoscopic assessments, namely the McGill Inanimate System for Training and Evaluation of Laparoscopic Skills (MISTELS) peg transfer task and the European Academy laparoscopic 'Suturing Training and Testing... |
Have their performance and cognitive workload parameters (SURG-TLX score, heart rate, and pupil metrics) evaluated during the tasks. conditions: Surgery studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: SINGLE_GROUP interventionModelDescription: Participants are randomly allocated to either... |
<|newrecord|> nctId: NCT06355583 id: C/42/2022 id: 2022-003617-10 type: EUDRACT_NUMBER briefTitle: Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial acronym: MAST overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2026-02-01 date: 2027-05-01 date: 2024-04-09 date: 2024-04-09 n... |
The main questions it aims to answer are: |
* Tolerability and acceptability of intestinal microbiota transplantation (IMT) versus placebo (as assessed via patient perspective questionnaires |
* Changes in gut microbiome diversity across all timepoints |
* Markers of general health, infective/microbiological and haematological outcomes including, days of fever, admission to intensive care unit, survival, non-relapsed mortality, and incidence of graft-versus-host disease across all time points measured. |
Participants will be asked at their routine follow up visits to, |
* Provide stool, urine and blood samples at the scheduled study visits |
* Complete questionnaires at selected visits |
* Swallow either Placebo or IMT capsules once at the second study visit which will occur 2 weeks prior to the stem cell transplant (+/-3 days) |
Researchers will compare IMT capsules and Placebo to investigate the change in gut microbiota diversity. conditions: Acute Lymphoblastic Leukaemia conditions: Acute Leukemia of Ambiguous Lineage conditions: Chronic Myeloid Leukemia conditions: Chronic Myelomonocytic Leukemia conditions: Myelodysplastic Syndrome conditi... |
<|newrecord|> nctId: NCT06355570 id: 331314 id: RFPR2324_29 type: OTHER_GRANT domain: Imperial Health Charity id: 24/YH/0011 type: OTHER domain: UK Health Research Authority (Research Ethics Committee) briefTitle: Delirium After Cardiac Surgery in Intensive Care Units acronym: DaCsi-ICU overallStatus: RECRUITING date: ... |
STUDY DESIGN The study will be conducted over twelve months in the Cardiac Intensive Care Unit (ICU) at Hammersmith Hospital, Imperial College Healthcare NHS Trust (ICHT). This study is a mixed methods research design that includes the collection of data through qualitative interviews, quality-of-life questionnaires an... |
AIMS |
* Determine the incidence of ICU delirium in ICHT following cardiac surgery |
* Explore the compliance of outcome measures that diagnose ICU delirium |
* Implement a family-focused sensory stimulation programme in the ICU |
* Evaluate its useability and potential impact on patients, families and ICU staff |
STUDY POPULATION 30 study participants (12 patients, 12 family members/friends and 6 ICU nurses) |
ELIGIBILITY Study eligibility criteria are specific for each care group (patients, family members/friends and ICU nurses). |
DURATION 12 months at Hammersmith Hospital, ICHT conditions: Intensive Care Unit Delirium conditions: Cardiac Surgery conditions: Post Operative Delirium studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: 12-patient participants will be submitted to the stu... |
<|newrecord|> nctId: NCT06355557 id: DSRB 2023/00640 briefTitle: Human vs Machine: a RCT Comparing Traditional In-person Instruction, AI Versus VR for Learning Basic CCE overallStatus: RECRUITING date: 2024-04-04 date: 2024-12-31 date: 2025-01 date: 2024-04-09 date: 2024-04-09 name: Tan Tock Seng Hospital class: OTHER ... |
<|newrecord|> nctId: NCT06355544 id: PINEAPPL2023 id: 2023-A02494-41 type: OTHER domain: Agence nationale de sécurité du médicament et des produits de santé briefTitle: Individual Factors Related to Chronic Low-grade Inflammation and Cardiometabolic Disease Risk acronym: PINEAPPL overallStatus: NOT_YET_RECRUITING date:... |
The main questions it aims to answer are: |
* Whether it is possible to predict low-grade inflammation |
* What are the medical, biological, and lifestyle variables related to low-grade inflammation? |
Participants will be asked to: |
1. Attend a general medical visit to collect vital signs, anthropometric measurements, and collect blood samples. |
2. Complete questionnaires and collect a stool sample at home. conditions: Overweight conditions: Obesity conditions: Metabolic Syndrome conditions: Healthy conditions: Low-grade Inflammation conditions: Normal Weight Adults conditions: Risk Factor, Cardiovascular conditions: Hypertension conditions: Hypercholesterolem... |
<|newrecord|> nctId: NCT06355531 id: FNP223-CT-2301 briefTitle: A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP) overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-11 date: 2026-11 date: 2024-04-09 date: 2024-04-09 name: Ferrer I... |
<|newrecord|> nctId: NCT06355518 id: INu-RC briefTitle: Pre-operative Immuno-Nutrition in Radical Cystectomy acronym: INu-RC overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-09 date: 2026-09 date: 2024-04-09 date: 2024-04-09 name: Fondazione IRCCS Policlinico San Matteo di Pavia class: OTHER name: IRCCS Osped... |
<|newrecord|> nctId: NCT06355505 id: PREPS-21-0098 briefTitle: Process of Emergence and Implementation of Advanced Practice Nursing in France acronym: PEIPA overallStatus: RECRUITING date: 2024-03-01 date: 2028-01-01 date: 2028-03-01 date: 2024-04-09 date: 2024-04-09 name: Assistance Publique - Hôpitaux de Paris class:... |
<|newrecord|> nctId: NCT06355492 id: 2090/10/30 briefTitle: Virtual Reality Distraction in Pediatric Patients. overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06 date: 2025-07 date: 2024-04-09 date: 2024-04-09 name: Tanta University class: OTHER briefSummary: The aim of this study is to evaluate the effec... |
<|newrecord|> nctId: NCT06355479 id: HY1001-2022-P3 briefTitle: A Study to Evaluate the Efficacy and Safety of OsrHSA in Patients of Hepatic Cirrhosis With Hypoalbuminemia overallStatus: COMPLETED date: 2023-04-10 date: 2023-11-22 date: 2023-12-12 date: 2024-04-09 date: 2024-04-09 name: Healthgen Biotechnology Corp. cl... |
Researchers will compare OsrHSA to the positive comparator, plasma-derived HSA (pHSA) to see if OsrHSA presents as non-inferior to pHSA in the indication of hypoalbuminemia in hepatic cirrhosis patients. |
Participants will be randomized in a 1:1 ratio to receive OsrHSA or HpHSA (20g IV qd) for up to 14 days, following an EOT visit. Follow-up visits will be taken on EOT+7d, EOT+14d, and EOT+30d, respectively. conditions: Hypoalbuminemia conditions: Hepatic Cirrhosis studyType: INTERVENTIONAL phases: PHASE3 allocation: RA... |
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