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Aims: To compare the efficacy and safety of a SCD versus MCD on glycemic control, metabolomic signatures, and pregnancy outcomes in pregnant individuals on IIT. conditions: Diabetes in Pregnancy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Open la... |
<|newrecord|> nctId: NCT06355141 id: E-15189967-050.04-494458 briefTitle: Oral Structural and Functional Problems in Children With Autism overallStatus: NOT_YET_RECRUITING date: 2024-04-11 date: 2024-05-13 date: 2024-08-12 date: 2024-04-09 date: 2024-04-09 name: Hacettepe University class: OTHER briefSummary: This stud... |
<|newrecord|> nctId: NCT06355128 id: 20240307 briefTitle: A Cross-sectional Study of Ocular Manifestations During the Covid-19 Pandemic in Hubei Province overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2024-02-18 date: 2024-04-30 date: 2024-04-09 date: 2024-04-09 name: Zhongnan Hospital class: OTHER name: Q... |
<|newrecord|> nctId: NCT06355115 id: 400/218/K.3/302/2023 briefTitle: Prophylactic Antibiotics Duration Towards Healing and Risk of Infection in Permanent Pacemaker (PPM) Installation acronym: PACE-PRO overallStatus: RECRUITING date: 2023-09-01 date: 2024-09-01 date: 2024-09-01 date: 2024-04-09 date: 2024-04-09 name: U... |
Nonetheless, the optimal duration of prophylactic antibiotics for PPM remains uncertain. Individual study results are ambiguous and debatable due to the fact that each center has its own policy governing the regimen for prophylactic antibiotic use. Accordingly, the goal of this clinical trial is to assess and compare t... |
The main questions it aims to answer are: |
1. What is the efficacy of different durations of prophylactic antibiotics (single dosage vs 3-day dosage) in preventing infective complications following PPM implantations? |
2. What factors may influence the optimum use of prophylactic antibiotics for individual patients undergoing PPM implantation to minimize the risk of infective complications? |
Researchers will compare a single dosage vs a 3-day dosage of prophylactic antibiotics following the PPM implantation procedure to see the risk of device-related infections. |
Participants will: |
* Be given a single-dose or 3-days dose of antibiotic regarding the PPM installations. |
* Visit the clinic for follow-ups and tests. conditions: Pacemaker Complication studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: NONE count: 100 type: ESTIMATED name: Cefazolin 1000 MG Injection measure: Number of participants with early poc... |
<|newrecord|> nctId: NCT06355102 id: 2024-SR-116 briefTitle: The Development of Tinnitus in Patients With SSNHL: Insights From fMRI and Metabolomics overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-12-31 date: 2026-03-31 date: 2024-04-09 date: 2024-04-09 name: The First Affiliated Hospital with Nanjing Med... |
* What are the peripheral and central influencing factors that contribute to tinnitus in patients with SSNHL? |
* Can serum metabolic biomarkers be identified to predict and monitor tinnitus prognosis in these patients? |
Participants in this study will include patients with SSNHL and tinnitus, patients with SSNHL without tinnitus, and healthy subjects. They will be asked to undergo a series of assessments, including audiological tests, vestibular function examinations, and functional magnetic resonance imaging (fMRI). Additionally, blo... |
Investigators will compare the brain functional states and serum metabolite profiles of patients with SSNHL and tinnitus to those without tinnitus. Morever, tinnitus symptom characteristics, audiological outcomes, and brain functional states will be assessed during time. conditions: Sudden Sensorineural Hearing Loss co... |
<|newrecord|> nctId: NCT06355089 id: VAR-MIKRO briefTitle: Intestinal Microbiota: Immunity, Recovery and Metabolic Health acronym: VAR-MIKRO overallStatus: COMPLETED date: 2023-01-09 date: 2023-09-07 date: 2023-09-07 date: 2024-04-09 date: 2024-04-09 name: University of Turku class: OTHER name: Government Body Funding ... |
<|newrecord|> nctId: NCT06355076 id: CSZ03 briefTitle: New Urethral Reconstruction in Robot-assisted Laparoscopic Radical Resection overallStatus: RECRUITING date: 2023-02-05 date: 2026-06 date: 2026-06 date: 2024-04-09 date: 2024-04-09 name: Qilu Hospital of Shandong University class: OTHER briefSummary: The purpose o... |
Is there a significant improvement in urinary control in patients with new reconstruction compared with patients with anastomosis? The researchers compared the new reconstruction with anastomosis in robot-assisted laparoscopic radical resection to see if the new reconstruction improved urinary incontinence after operat... |
Participants will: |
The intervention group adopted the new reconstruction proposed by our team; End-to-end anastomosis was performed in non-intervention group. conditions: Prostate Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The experimental group received a ... |
<|newrecord|> nctId: NCT06355063 id: NP-PCF-037 briefTitle: CellFX® nsPFA™ Cardiac Surgery System to Treat Atrial Fibrillation overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2025-08-31 date: 2025-10-31 date: 2024-04-09 date: 2024-04-09 name: Pulse Biosciences, Inc. class: INDUSTRY briefSummary: This feasibili... |
<|newrecord|> nctId: NCT06355050 id: UKJ-ultraHART briefTitle: Ultrahypofractionated, Adaptive Radiation Therapy of Prostate Cancer acronym: ultraHART overallStatus: NOT_YET_RECRUITING date: 2024-06-30 date: 2026-09-30 date: 2031-09-30 date: 2024-04-09 date: 2024-04-09 name: Jena University Hospital class: OTHER name: ... |
<|newrecord|> nctId: NCT06355037 id: B2024.1.30 briefTitle: Dasatinib Combined With Quercetin to Reverse Chemo Resistance in Triple Negative Breast Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-12-31 date: 2025-01-31 date: 2024-04-09 date: 2024-04-09 name: Fudan University class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06355024 id: A2024.1.30 briefTitle: Inosine Reverse Chemo Resistance in Triple Negative Breast Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-12-31 date: 2025-01-31 date: 2024-04-09 date: 2024-04-09 name: Fudan University class: OTHER briefSummary: This is a Phase II, open-... |
<|newrecord|> nctId: NCT06355011 id: 7016194 briefTitle: Total Elbow Replacement in England: Analysis of National Joint Registry and Hospital Episode Statistics Data overallStatus: COMPLETED date: 2024-03-01 date: 2024-04-02 date: 2024-04-02 date: 2024-04-09 date: 2024-04-09 name: University of Manchester class: OTHER ... |
* Who are receiving primary total elbow replacement surgery? |
* Where and by whom is the total elbow replacement surgery is being performed? |
* What the current surgical practices for total elbow replacement? |
Pseudonymous data from the National Joint Registry NJR of all patients with total elbow replacement will be used. conditions: Total Elbow Replacement studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 3891 type: ACTUAL name: Total Elbow Replacement measure: The incidence of total el... |
<|newrecord|> nctId: NCT06354998 id: mRNA-1273-P401 briefTitle: A Study of an Investigational mRNA-1273.815 COVID-19 Vaccine in Previously Vaccinated Adults overallStatus: RECRUITING date: 2024-04-08 date: 2024-06-01 date: 2024-06-01 date: 2024-04-09 date: 2024-04-22 name: ModernaTX, Inc. class: INDUSTRY briefSummary: ... |
<|newrecord|> nctId: NCT06354985 id: 23-5996 id: MODEX2023 type: OTHER domain: Clinical Trial Protocol Number id: FRN:183960 type: OTHER_GRANT domain: CIHR id: CTO Project ID: 4701 type: OTHER domain: Clinical Trials Ontario briefTitle: Modafinil and Exercise for Post Stroke Fatigue acronym: MODEX overallStatus: NOT_YE... |
Some studies have tested a drug called Modafinil for post stroke fatigue, while other studies have tested exercise for it. Yet, there is unclear evidence for either treatment, so this study has two main aims: |
1. Test if Exercise Program One is better than Exercise Program Two |
2. Test if Modafinil is better than a Sugar Pill |
As another aim, the investigators will also look at if combining Modafinil with exercise has any benefits. |
This study will take place at 6 Canadian research sites to give a good representation of people after a stroke. Each person will be tested on fatigue, mood, fitness, thinking skills, sleep, and usual activity levels. |
Participants will be assigned at random (like flipping a coin) to 1 of 4 groups: |
1. Sugar Pill plus Exercise Program One |
2. Sugar Pill plus Exercise Program Two |
3. Modafinil plus Exercise Program One |
4. Modafinil plus Exercise Program Two |
The treatment will last 8 weeks. The Modafinil or Sugar Pill will be taken once a day. The exercise will be delivered virtually by a trained therapist over computer to people at home 3 times a week. Change in fatigue, quality of life, and other outcomes will be measured over 6 months. |
The investigators will assess the results to identify the best treatment for post stroke fatigue and hope to be able to find a treatment that will help reduce fatigue and improve quality of life after a stroke. conditions: Stroke conditions: Fatigue conditions: Modafinil conditions: Exercise studyType: INTERVENTIONAL p... |
<|newrecord|> nctId: NCT06354972 id: SASP Turin briefTitle: Impact of SASP in the GCF on the Outcomes of Periodontal Regeneration overallStatus: COMPLETED date: 2022-01-02 date: 2022-11-02 date: 2024-01-02 date: 2024-04-09 date: 2024-04-09 name: University of Turin, Italy class: OTHER briefSummary: Objectives: To test ... |
Methods: Sites associated with intrabony defects ≥ 3 mm requiring periodontal regeneration through minimally-invasive surgical technique were included. Pre-operatively, GCF was sampled for inflammatory biomarker analysis related to SASP \[interleukin (IL)-1β, IL-6 and IL-12; matrix-metalloproteinases (MMP)-8 and -9\]. ... |
<|newrecord|> nctId: NCT06354959 id: 1030020 briefTitle: Prehab for Lung and Esophageal Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-06-01 date: 2027-01-01 date: 2024-04-09 date: 2024-04-09 name: Nova Scotia Health Authority class: OTHER name: Dalhousie University briefSummary: Research indicate... |
<|newrecord|> nctId: NCT06354946 id: SCORE 4C briefTitle: External Validation of Simplified 4C Mortality Score by Deleting CRP acronym: 4Cs overallStatus: COMPLETED date: 2020-01-01 date: 2022-11-30 date: 2022-12-30 date: 2024-04-09 date: 2024-04-09 name: University of Monastir class: OTHER briefSummary: The (Coronavir... |
<|newrecord|> nctId: NCT06354933 id: DemeNSS (3785) briefTitle: Neurological Soft Signs in Neurodegenerative Dementias acronym: DemeNSS overallStatus: COMPLETED date: 2022-04-01 date: 2023-11-30 date: 2024-02-01 date: 2024-04-09 date: 2024-04-15 name: University of Milano Bicocca class: OTHER briefSummary: The goal of ... |
* Does the prevalence of NSS significantly differ among patients with neurodegenerative dementias compared to controls? |
* Are NSS associated with neuropsychiatric alterations in dementia patients? |
* Do NSS correlate with cognitive screening tools? |
* Do NSS increase over time in patients with neurodegenerative dementias? |
Participants will undergo assessments including: |
* Evaluation of NSS using the Heidelberg scale |
* Neuropsychiatric assessments |
* Cognitive screening using the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB) |
Researchers will compare dementia groups (Alzheimer's disease, Frontotemporal dementia, Corticobasal syndrome and Lewy body dementia) to controls to determine differences in NSS prevalence. Additionally, associations between NSS and neuropsychiatric symptoms, as well as cognitive performance, will be explored. conditio... |
<|newrecord|> nctId: NCT06354920 id: HUM00247781 id: R18HS028963 type: AHRQ link: https://reporter.nih.gov/quickSearch/R18HS028963 briefTitle: M-Well Bonding Bundle to Improve Patient-Physician Relationships overallStatus: RECRUITING date: 2024-04-08 date: 2026-06 date: 2026-06 date: 2024-04-09 date: 2024-04-10 name: U... |
* Will using the intervention strategies improve doctors' empathy towards their patients? |
* Will using the intervention strategies lead to improved scores in patient views of doctors' empathy? |
There will be 2 study arms. One group of doctors will be asked to use the intervention strategies. The other group of doctors will provide care as they would normally. |
Researchers will compare the doctors in the intervention arm to those in the control arm. |
Doctors are the primary subjects for this study. The doctors in both study arms will be asked to do the following: |
1. Allow study staff to observe the interaction between them and their patients. |
2. Complete a brief survey at the end of their 2-week work rotation. |
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