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6. Inform patient and family for further intervention |
Polytrauma patients in the control group will receive the usual/standard intervention. |
Response time, early warning score, and arterial blood gas of polytrauma patients from both groups will be obtained and documented before and after the intervention. conditions: Polytrauma studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE w... |
<|newrecord|> nctId: NCT06351813 id: B2024-029R briefTitle: Predicting Adverse Kidney Events of Cardiac Surgery-Associated Acute Kidney Injury Using Novel Biomarkers overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-12-31 date: 2027-12-31 date: 2024-04-08 date: 2024-04-08 name: Shanghai Zhongshan Hospital c... |
<|newrecord|> nctId: NCT06351800 id: PE-0280-2018 briefTitle: The PredictPlusPrevent Study overallStatus: NOT_YET_RECRUITING date: 2024-09-15 date: 2025-12-31 date: 2026-04-30 date: 2024-04-08 date: 2024-04-08 name: The Mediterranean Institute for the Advance of Biotechnology and Health Research class: OTHER briefSumma... |
Methods: A double-blind, parallel-group, randomized controlled trial with a twelve-month follow-up. The entire process of recruitment, random allocation, intervention, and follow-up will be conducted through the 'PredictPlusPrevent' platform and its associated apps. Following a media campaign, at least 9,000 Spanish pa... |
<|newrecord|> nctId: NCT06351787 id: 22-X-97 briefTitle: Project Soma: Cortical Activity of a Body Scan Meditation and Yoga Practice in Healthy Yogis overallStatus: COMPLETED date: 2022-10-31 date: 2023-06-28 date: 2023-06-28 date: 2024-04-08 date: 2024-04-08 name: Ohio University class: OTHER briefSummary: In this 2-a... |
Specifically, we will examine the correlates of interoceptive awareness and mindful awareness with cortical activity (Aim 1a) and pain tolerance (Aim 1b); determine cortical activity responsiveness of two brief awareness-focused meditations - a resting-based body scan practice and yoga practice (Aim 2a); characterize c... |
Our central hypotheses are that (Aim 1a) higher interoceptive awareness and mindful awareness will moderately correlate with higher cortical activity for both awareness-focused meditation practices; (Aim 1b) individuals sub-grouped into the 'acceptance in action cluster' based on 2 self-report measures will exhibit hig... |
<|newrecord|> nctId: NCT06351774 id: 21-F-45 briefTitle: Project AdaPT: An Adaptive Physiotherapy Intervention Augmented With a Healthy Mind Training Program for People With Chronic Low Back Pain acronym: AdaPT overallStatus: COMPLETED date: 2022-05-24 date: 2024-02-08 date: 2024-03-25 date: 2024-04-08 date: 2024-04-08... |
<|newrecord|> nctId: NCT06351761 id: SCT02-ECG briefTitle: WIBOFA - Validation of SCT02 With ECG-App for Detection of AF acronym: WIBOFA overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-01 date: 2025-03 date: 2024-04-08 date: 2024-04-08 name: Withings class: INDUSTRY briefSummary: The aim of the study is to e... |
<|newrecord|> nctId: NCT06351748 id: NN9535-7877 id: U1111-1296-3151 type: OTHER domain: World Health Organization (WHO) briefTitle: Real-world Study of CHina Ozempic cLinicAl pRactice in Patients With Type 2 Diabetes (SCHOLAR) acronym: SCHOLAR overallStatus: ENROLLING_BY_INVITATION date: 2024-04-05 date: 2024-06-30 da... |
<|newrecord|> nctId: NCT06351735 id: 2024-0336 briefTitle: Efficacy and Safety of Deep Cervical Lymph Node-vein Bypass Surgery in ALS Amyotrophic Lateral Sclerosis overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-01 date: 2027-05-01 date: 2024-04-08 date: 2024-04-08 name: Second Affiliated Hospital, Sch... |
<|newrecord|> nctId: NCT06351722 id: smokingnlrp3inflasome briefTitle: Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAs overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-12-15 date: 2025-03-15 date: 2024-04-08 date: 2024-04-08 name: Necmettin Erbakan University class: ... |
The main questions it aims to answer are: |
question 1: Is there a relationship between the biomarkers mentioned above and periodontitis and smoking? question 2:How do the above-mentioned biomarkers change after NSPT in smokers and non-smokers? conditions: Periodontitis, Adult studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE... |
<|newrecord|> nctId: NCT06351709 id: UmutPaksoy briefTitle: Acute Effects of Heat, Cold and Stretching on Knee Proprioception and Vertical Jump overallStatus: COMPLETED date: 2020-11-02 date: 2021-02-20 date: 2021-02-20 date: 2024-04-08 date: 2024-04-08 name: Istanbul Bilgi University class: OTHER briefSummary: The aim... |
<|newrecord|> nctId: NCT06351696 id: 43008563 briefTitle: The Effects of Bromelain Supplement in Patients With Ulcerative Colitis overallStatus: RECRUITING date: 2024-04-20 date: 2024-07-20 date: 2024-08-10 date: 2024-04-08 date: 2024-04-09 name: National Nutrition and Food Technology Institute class: OTHER briefSummar... |
IBDQ, SCCAIQ, CRP, TAC, TNF-a will be measured before and after the intervention. conditions: Ulcerative Colitis conditions: Primary Sclerosing Cholangitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMaske... |
<|newrecord|> nctId: NCT06351683 id: 24-066-2 id: P30AG067988 type: NIH link: https://reporter.nih.gov/quickSearch/P30AG067988 briefTitle: Testing MitoQ on Lower Urinary Tract Symptoms in Older Women With Metabolic Syndrome acronym: Mito-LUTS overallStatus: RECRUITING date: 2024-04-03 date: 2025-12 date: 2025-12 date: ... |
* Is the study design feasible and acceptable to participants? |
* Do participants taking the study drug get any improvement to their bladder symptoms compared to participants taking a placebo (a look-alike substance that contains no drug)? |
Participants will take 2 capsules of the study drug every morning for 4 months, answer many questions about their health including questions about their bladder health, perform physical and cognitive testing, give blood and urine samples, collect urine over 24 hour periods 3 times over the 4 months of the study, comple... |
<|newrecord|> nctId: NCT06351670 id: 1109/2024 briefTitle: Personalised Monitoring of Early and Intermediate Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression acronym: SUDETES overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2027-07 date: 2027-07 date: 2024-04-... |
* Identify and quantify focal and global alterations in the retina in regard to disease progression. |
* Assess the individual risk of disease progression in intermediate AMD patients converting to advanced AMD based on imaging. |
* Specify the course of disease in regard to the sequence of events that lead to the conversion to advanced AMD |
* Enhance the ability to classify AMD using artificial intelligence in addition to traditional models. |
All patients will be followed for 24 months with 6 month intervals to assess clinical changes. Monitoring of disease progression will be performed using the following routine in-vivo imaging procedures: |
* Scanning Laser Fundus Photography |
* Color Fundus Photography (CFP) |
* Optical Coherence Tomography (OCT) |
* Optical Coherence Tomography Angiography (OCTA) Patients will be asked for their medical history. Standard ophthalmic examination, as well as a questionnaire on visual function will be carried out. |
No intervention will be performed during the study since no treatment is yet available within Europe. As soon as treatment is approved in the EU, patients in this cohort might receive treatment according to availability in their respective country and standard of care. If treatment will be performed, it will be as stan... |
<|newrecord|> nctId: NCT06351657 id: 1088/2024 briefTitle: Personalized Monitoring of Non-foveal, Non-vision Compromising Atrophic Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression acronym: APENNINES overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2027-07 date... |
* Assess the individual progression rate of a patient in non-foveal, non-vision compromising atrophic AMD and assess personalized risk of progression based on imaging. |
* Identify and quantify focal and global alterations in the retina in regard to disease progression. |
* Evaluate the monitoring of AMD progression using approved AI algorithms. |
All patients will be followed for 24 months with 6 month intervals to assess clinical changes. Monitoring of disease progression will be performed using the following routine in-vivo imaging procedures: |
* Scanning Laser Fundus Photography |
* Color Fundus Photography (CFP) |
* Optical Coherence Tomography (OCT) |
* Optical Coherence Tomography Angiography (OCTA) |
Patients will be asked for their medical history. Standard ophthalmic examination, as well as a questionnaire on visual function will be carried out. |
No intervention will be performed during the study since no treatment is yet available within Europe. As soon as treatment is approved in the EU, patients in this cohort might receive treatment according to availability in their respective country and standard of care. If treatment will be performed, it will be as stan... |
<|newrecord|> nctId: NCT06351644 id: STUDY-24-00244 briefTitle: ON 123300 (Narazaciclib) and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma overallStatus: NOT_YET_RECRUITING date: 2024-06-03 date: 2028-06-05 date: 2028-06-05 date: 2024-04-08 date: 2024-04-08 name: Adriana Rossi class: OTHER ... |
In this study, the researchers will test the safety and preliminary efficacy of inhibition of CDK4 and ARK5 by ON 123300 (NARAZACICLIB) in combination with dexamethasone in myeloma patients in a Phase I/II clinical trial. conditions: Relapsed and/or Refractory Multiple Myeloma studyType: INTERVENTIONAL phases: PHASE1 p... |
<|newrecord|> nctId: NCT06351631 id: 3543-017 id: 2023-506996-89 type: OTHER domain: EU CT id: U1111-1294-8621 type: OTHER domain: UTN id: MK-3543-017 type: OTHER domain: Merck ID briefTitle: A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017) overallStatus: NOT_YET_RECRUITING date: 2024-05-21 date: 20... |
* Participants from the IMG-7289-202/MK-3543-005 (NCT05223920) study must have received at least 6 months of treatment with bomedemstat; |
* Essential thrombocythemia (ET) and polycythemia vera (PV) participants from studies other than IMG-7289-202/MK-3543-005 must have achieved confirmed hematologic remission. |
No hypothesis testing will be conducted in this study. conditions: Thrombocythemia, Essential conditions: Primary Myelofibrosis conditions: Myelofibrosis conditions: Post-polycythemia Vera Myelofibrosis conditions: Post-essential Thrombocythemia Myelofibrosis conditions: Polycythemia Vera studyType: INTERVENTIONAL phas... |
<|newrecord|> nctId: NCT06351618 id: 2023-06114-01 briefTitle: Epidemiology of Injuries in the Professional Women's Swedish National IceHockey League Permitted to Body-Checking overallStatus: RECRUITING date: 2023-12-01 date: 2024-03-26 date: 2028-01-01 date: 2024-04-08 date: 2024-04-08 name: Lund University class: OTH... |
<|newrecord|> nctId: NCT06351605 id: CSP006 briefTitle: A Registry Study to Assess Photobiomodulation in Dry Age-Related Macular Degeneration (EUROLIGHT) (EUROLIGHT) overallStatus: RECRUITING date: 2023-09-01 date: 2026-09 date: 2026-12 date: 2024-04-08 date: 2024-04-08 name: LumiThera, Inc. class: INDUSTRY briefSummar... |
<|newrecord|> nctId: NCT06351592 id: ALN-SOD-ALS-2351 id: 2023-510344-20-00 type: REGISTRY domain: EU CT Number briefTitle: First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS) overallStatus: NOT_YET_RECRUITING date: 2024-06-... |
The study is looking at several other research questions, including: |
* The effect the study drug has on specific biomarkers, which are molecules in the blood or in the fluid that surrounds the brain and spinal cord, known as cerebrospinal fluid (CSF) |
* How much study drug is in the blood and in the CSF, at different times |
* Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects) |
* What effects the study drug has on ALS symptoms conditions: Amyotrophic Lateral Sclerosis (ALS) conditions: Mutation in the Superoxide Dismutase-1 (SOD1) Gene studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: QUADRUPLE maskingDescription: ... |
<|newrecord|> nctId: NCT06351579 id: 1010159 briefTitle: Data Collection Post Radical Prostatectomy acronym: ALTO overallStatus: NOT_YET_RECRUITING date: 2024-06-15 date: 2025-12-30 date: 2026-03-15 date: 2024-04-08 date: 2024-04-08 name: Levee Medical, Inc. class: INDUSTRY name: RQMplus briefSummary: The study is to c... |
<|newrecord|> nctId: NCT06351566 id: VD3, Prebiotics in Diabetes briefTitle: Effects of Vitamin D3 and Prebiotics Supplementation on Cardiovascular Risk Factors in Patients With Type 2 Diabetes overallStatus: NOT_YET_RECRUITING date: 2024-04-24 date: 2024-12-31 date: 2025-12-31 date: 2024-04-08 date: 2024-04-22 name: H... |
<|newrecord|> nctId: NCT06351553 id: 2023-169 briefTitle: Effect of the Autonomic Nervous System on the Outcomes of PULSEd Field Ablation to Treat Atrial Fibrillation acronym: EASy-PULSE AF overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-06 date: 2026-06 date: 2024-04-08 date: 2024-04-08 name: Hospital Gener... |
The investigators propose to carry out a single-center clinical trial, although with the possibility in the future of including other centers. Patients will be randomized to three research groups: PV isolation with RF, PV isolation with PFA, and PV isolation combining PFA and RF (using RF on the anterior wall and PFA o... |
<|newrecord|> nctId: NCT06351540 id: IRB00332797 id: R21DA056687 type: NIH link: https://reporter.nih.gov/quickSearch/R21DA056687 briefTitle: Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2025-08-01... |
<|newrecord|> nctId: NCT06351527 id: ICP-CL-01202 briefTitle: Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ICP-248 in Mature B-cell Malignancies overallStatus: NOT_YET_RECRUITING date: 2024-04-25 date: 2027-06-25 date: 2027-10-25 date: 2024-04-08 date: 2024-04-08 name: InnoCare Pharm... |
<|newrecord|> nctId: NCT06351514 id: 2023/00745 briefTitle: An Open-Label, Single Arm Study of the Efficacy of Accelerated Intermittent Theta Burst Stimulation in Schizophrenia Patients With Persistent Negative Symptoms acronym: NOBLE-TMS overallStatus: RECRUITING date: 2024-04-01 date: 2026-09 date: 2026-09 date: 2024... |
We propose a pragmatic, open label and single arm clinical trial. Forty patients with diagnosis of schizophrenia, who had been stabilized from psychotic symptoms and currently suffering from dominant negative symptoms will be recruited and undergo accelerated iTBS treatment for 5 consecutive sessions each day for 5 wor... |
This study will determine whether accelerated iTBS is effective to be delivered as an augmentation therapy for patients with persistent negative symptoms. The optimal treatment system for this population can be immediately translated to clinical practice and benefit patients in need. conditions: Schizophrenia; Negative... |
<|newrecord|> nctId: NCT06351501 id: P170923J id: 2019-000300-16 type: EUDRACT_NUMBER briefTitle: Evaluation of the Effectiveness of Hormonal Treatment in Adolescents Suffering From Gender Dysphoria acronym: TRANSADO overallStatus: NOT_YET_RECRUITING date: 2024-06-06 date: 2029-06-06 date: 2031-06-06 date: 2024-04-08 d... |
Our hypothesis is that when hormonal transition is started at an age closer to what physiological puberty would be, it will reduce comorbidities and improve quality of life of these adolescents. This is the first therapeutic randomized study in France on this transgender adolescent population, a field where internation... |
<|newrecord|> nctId: NCT06351488 id: APHP231661 briefTitle: Detection of Circulating Kidney DNA in Kidney Transplant Patients Facing an Episode of Graft Rejection acronym: DART-RREGREF overallStatus: NOT_YET_RECRUITING date: 2024-06-10 date: 2026-02-11 date: 2026-02-11 date: 2024-04-08 date: 2024-04-08 name: Assistance... |
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