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Several studies have shown the possibility of identifying the tissue origin of DNA circulating in the blood, in healthy subjects, on the basis of the epigenetic properties of circulating DNA. In addition, in kidney transplant subjects, an increase in the quantity of circulating DNA originating from the graft in the blo... |
<|newrecord|> nctId: NCT06351475 id: APHP230864 briefTitle: Efficacy of Intraoperative Use of 20% Albumin Combined With Ringer Lactate Versus Ringer Lactate During Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy acronym: ALBUCHIP overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-10 date: 2... |
Methods and analysis The study protocol has been designed and written in accordance with the Prospective randomised, comparative, controlled, prospective, open-label, with parallel group and multicentre clinical trial. |
Recruitment, randomisation and allocation Information on the study and screening of patients will be conducted during the consultation of anaesthesia (= selection visit), 2 months at 3 days before the surgery. Information notice and consent form will be delivered. The day before the surgery, anaesthesiologist who will ... |
Randomized Open, Blinded endpoint (PROBE) design. This study is a randomised, comparative, controlled, prospective, open-label, with parallel group and multicentre clinical trial. |
Intervention |
* 20% Albumin + Ringer Lactate group (intervention group) Per-operative fluid therapy consisting in Ringer Lactate combined with 20% albumin. Patients will receive a bolus of 3 mL/kg on one hour of 20% albumin from anaesthetic induction. Then, infusion of 20% albumin (100 mL, 20g) will be administered for each 1200 mL ... |
* Control group Ringer Lactate for intra operative fluid management based on the latest scientific recommendations. As the the study is an open labelled randomized clinical trial, placebo use is not planned. |
Outcome measures The primary outcome will be the Comprehensive Complication Index (CCI score) at day 28 after CRS with HIPEC. Secondary outcomes are mortality at day 28, CCI score at day 7, volume of intra operative and post operative (48h) post operative fluid therapy, cumulated incidence of surgical post operative co... |
Sample size calculation To ensure a power of 80%, a number of patients 130 (65 patients by group) will be necessary with a reduction of 13.6 (SD 24) points of the CCI score at day 28 in the intervention group. Because of a risk of neoplastic evolution between anaesthetic consultation and randomisation (10% of early can... |
Discussion In summary, ALBUCHIP study will be the first randomized clinical trial assessing efficacy of intraoperative use of 20% albumin combined with Ringer Lactate versus Ringer Lactate during CRS with HIPEC. Results yielded from this study will be helpful for vascular filling during CRS with HIPEC but, thanks to an... |
<|newrecord|> nctId: NCT06351462 id: APHP200008 briefTitle: Comparative Health Status and Quality of Life of Patients With Sickle Cell Disease (SCD) Who Underwent Matched-sibling Hematopoietic Stem Cell Transplantation Versus Non Transplanted SCD Case-control Patients acronym: TRANSPLANTORN2 overallStatus: NOT_YET_RECR... |
The main objective is to assess the benefit of Hematopoietic stem cell transplantation (HSCT) regarding quality of life compared to standard care after 10 years, in patients with severe Sickle Cell Disease (SCD). conditions: Sickle Cell Disease studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventio... |
<|newrecord|> nctId: NCT06351449 id: 69HCL22_0489 briefTitle: Characterization of Visual Characteristics in Allergic Contact Dermatitis Using the Skincam® Tool acronym: PatchCam overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-04-15 date: 2027-04-30 date: 2024-04-08 date: 2024-04-08 name: Hospices Civils d... |
The patch test method aims at reproducing the eczematous lesions by applying occlusive patches containing the suspected allergens to the patient's healthy skin. It requires experienced medical staff to read the reaction. |
Newtones Technologies society has developed a new tool, the SkinCam®, able to capture high resolution cross and parallel images, allowing a quantification of color and relief of skin. |
This study aims to illustrate patch test results, describing skin appearance (color, roughness, shine), using photographs taken by the SkinCam®. conditions: Allergic Contact Dermatitis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED name: The patch under study... |
<|newrecord|> nctId: NCT06351436 id: TBC20240402 briefTitle: Virtual Reality Cave Experience With Mindfulness for Mental Wellbeing overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2025-08 date: 2025-08 date: 2024-04-08 date: 2024-04-08 name: The Hong Kong Polytechnic University class: OTHER briefSummary: The aim o... |
A single-group pre-post uncontrolled design will be employed. Evaluations will be conducted at baseline (0 weeks) and post-intervention (3 months). conditions: Anxiety studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Single-group non-randomized uncontroll... |
<|newrecord|> nctId: NCT06351423 id: HE-NHS2023/03 briefTitle: The Effectiveness of MIND Diet and Forest Bathing on Stress Reduction overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2024-08-31 date: 2024-11-30 date: 2024-04-08 date: 2024-04-23 name: Hong Kong Metropolitan University class: OTHER briefSummary: T... |
1. what is the effect of FB on stress reduction |
2. what is the effect of MIND on stress reduction |
Participants of the MIND-FB group will participate will receive |
1. FB: a two-hour FB session on four consecutive weekends in a country park, |
2. MIND: four nutrition sessions, and adhere to the MIND diet for 12 weeks |
Researchers will compare the FB and routine care groups to compare the effectiveness of MIND and FB in reducing psychological stress. conditions: Anxiety conditions: Depression conditions: Stress conditions: Psychological Stress studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL int... |
<|newrecord|> nctId: NCT06351410 id: JEP 2023-679 briefTitle: Assessment of Tear Production, Corneal Staining, and Comfort Level Wearing Different Types of Contact Lenses overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2024-07-30 date: 2025-02-28 date: 2024-04-08 date: 2024-04-19 name: National University of M... |
<|newrecord|> nctId: NCT06351397 id: 75021 briefTitle: Immersive Mixed Reality Simulation to Evoke Empathy acronym: Empathy overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-06-30 date: 2025-06-30 date: 2024-04-08 date: 2024-04-12 name: Stanford University class: OTHER briefSummary: This is a quantifiable s... |
<|newrecord|> nctId: NCT06351384 id: 20230744 briefTitle: Early Detection and Risk Stratification of Colorectal Cancer Based on miRNA Platform overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-10-01 date: 2025-12-31 date: 2024-04-08 date: 2024-04-08 name: Sir Run Run Shaw Hospital class: OTHER briefSummary:... |
Blood miRNA markers will be evaluated. The study will enroll approximately 600 participants, including participants with malignancies or benign diseases, and healthy participants. conditions: Colorectal Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 600 type: ESTIMATED na... |
<|newrecord|> nctId: NCT06351371 id: NCI-2024-01153 id: NCI-2024-01153 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: EAY131-K2 type: OTHER domain: ECOG-ACRIN Cancer Research Group id: EAY131-K2 type: OTHER domain: CTEP id: U10CA180820 type: NIH link: https://reporter.nih.gov/quickSearch/U10CA180820... |
<|newrecord|> nctId: NCT06351358 id: GLI.04.US.SL.036 briefTitle: Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies overallStatus: RECRUITING date: 2024-02-19 date: 2024-10-31 date: 2024-10-31 date: 2024-04-08 date: 2024-04-11 name: Galderma R&D class: INDUS... |
<|newrecord|> nctId: NCT06351345 id: Pro00115215 briefTitle: 129 Xenon Imaging in Patients Treated With Sotatercept acronym: Sox-PH overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-08-01 date: 2025-08-01 date: 2024-04-08 date: 2024-04-08 name: Bastiaan Driehuys class: OTHER name: Merck Sharp & Dohme LLC br... |
<|newrecord|> nctId: NCT06351332 id: 24-005 briefTitle: A Phase I/II Single-arm Trial of Azenosertib (ZN-c3) Combined With Carboplatin and Pembrolizumab in Patients With Metastatic Triple-negative Breast Cancer (ZAP-IT) overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2027-03-01 date: 2029-09-01 date: 2024-04-08 d... |
The names of the study drugs involved in this study are: |
* Azenosertib (a type of WEE1 inhibitor) |
* Carboplatin (a type of platinum compound) |
* Pembrolizumab (a type of monoclonal antibody) conditions: Breast Cancer conditions: Breast Cancer Female conditions: Triple Negative Breast Cancer conditions: Hormone Receptor Negative Malignant Tumor Breast Triple conditions: HER2-negative Breast Cancer studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocat... |
<|newrecord|> nctId: NCT06351319 id: HenanPPH-zhangquncheng briefTitle: Endobronchial Ultrasound-based SVM Model for Differentiating Benign and Malignant Mediastinal and Hilar Lymph Nodes overallStatus: COMPLETED date: 2018-01-01 date: 2023-12-01 date: 2024-04-01 date: 2024-04-08 date: 2024-04-08 name: Quncheng Zhang c... |
Methods: The clinical and ultrasonic image data of 197 patients wereretrospectively analyzed. The radiomics features were extracted by EBUS.based radiomics and dimensionality reduction was performed on thesefeatures by the least absolute shrinkage and selection operator (LASSO)EBUS-based radiomics model was established... |
<|newrecord|> nctId: NCT06351306 id: AAAU5915 briefTitle: DEC-C and Thioguanine for R/R AML overallStatus: RECRUITING date: 2024-01-30 date: 2027-12 date: 2027-12 date: 2024-04-08 date: 2024-04-08 name: Joseph Jurcic class: OTHER briefSummary: The purpose of this study is to find out if oral decitabine-cedazuridine (In... |
This is a "phase II trial with a safety lead-in." The goal of the lead-in portion of the study is to make sure participants are getting the highest dose of medications that are safe. If too many serious side effects are seen with the dose previously studied, some additional patients may be treated with a lower dose to ... |
<|newrecord|> nctId: NCT06351293 id: GLI.04.US.SL.034 briefTitle: A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction overallStatus: ENROLLING_BY_INVITATION date: 2024-02-21 date: 2025-02-28 date: 2025-02-28 date: 2024-04-08 date: 2024-04-11 name: Galderma R&D class: INDUSTRY briefSumma... |
4 weeks after the initial treatment, subjects will receive optional touch-up on one side or both sides at the Investigator's discretion for optimal correction. |
Subjects to return to the site at Month 3, 6, and 12 for follow-ups. conditions: Wrinkle studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Subjects will be blinded to the treatment assignment, in which randomization and ... |
<|newrecord|> nctId: NCT06351280 id: Sana Nasir Zaidi briefTitle: Evaluation of Performance-based Functional Outcome Measures After Open Abdominal Surgery overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-06 date: 2024-07 date: 2024-04-08 date: 2024-04-08 name: Riphah International University class: OTHER brie... |
<|newrecord|> nctId: NCT06351267 id: REC/RCR & AHS/23/0568 briefTitle: Combined Effects of Core Stability Exercises and Back Strengthening Exercises on Pregnancy-Induced Back Pain. overallStatus: NOT_YET_RECRUITING date: 2024-04-05 date: 2024-10-01 date: 2024-10-15 date: 2024-04-08 date: 2024-04-08 name: Riphah Interna... |
<|newrecord|> nctId: NCT06351254 id: REC/RCR & AHS/23/01101nayab briefTitle: Kinesthetic Exercises and Sine Sound Waves in Cervical Spondylosis overallStatus: RECRUITING date: 2023-11-20 date: 2024-06-01 date: 2024-06-01 date: 2024-04-08 date: 2024-04-08 name: Riphah International University class: OTHER briefSummary: ... |
Weather sine sound and kinesthetic exercise are effective in management of pain, rom, alignment, and disability in patients that are suffering from cervical spondylosis conditions: Cervical Spondylosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT mask... |
<|newrecord|> nctId: NCT06351241 id: E.222840/280 briefTitle: Hemodynamic Effects of Steep Trendelenburg Position and Pneumoperitoneum overallStatus: COMPLETED date: 2022-11-29 date: 2023-04-14 date: 2023-04-14 date: 2024-04-08 date: 2024-04-08 name: Ege University class: OTHER briefSummary: BACKGROUND: The steep Trend... |
METHODS: Fifty-three patients scheduled for RALRP underwent standard monitoring; PI and PVI values were monitored using a finger probe. PI, PVI, hemodynamic and respiratory parameters, and intraabdominal pressure were recorded before and after anesthesia induction, after adopting the Trendelenburg position, after pneum... |
<|newrecord|> nctId: NCT06351228 id: 5720 briefTitle: Fertility-sparing in Early-stage Cervcial Cancer: The ETERNITY Project acronym: Eternity overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2024-12-31 date: 2024-12-31 date: 2024-04-08 date: 2024-04-08 name: Fondazione IRCCS Istituto Nazionale dei Tumori, Mila... |
The primary aim is to report outcomes of those patients. |
Other aims included: |
1. Evaluation about the effectiveness of different treatment modalities; |
2. Evaluation of outcomes according to different stages of disease; |
3. Evaluation of the impactof neoadjuvant chemotherapy in patients undergoing conservative surgery conditions: Cervical Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 400 type: ESTIMATED name: Conization plus nodal evaluation measure: oncological outcomes sex: FEMALE mi... |
<|newrecord|> nctId: NCT06351215 id: APP-24-00554 briefTitle: PO Methadone Ortho Outpatient overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2024-12-01 date: 2024-12-15 date: 2024-04-08 date: 2024-04-08 name: Keck School of Medicine of USC class: OTHER briefSummary: The goal of this clinical trial is to learn i... |
Does oral methadone improve post-operative pain scores as compared to standard treatment? Does oral methadone lead to reduced use of post-operative and post-discharge opioid usage as compared to the current standard treatment? |
Researchers will compare oral methadone to a placebo (a look-alike substance that contains no drug) to assess the questions above. |
Participants will: |
Receive either oral methadone or a look-alike placebo before surgery Receive standard intraoperative and immediate post-operative pain control at the anesthesiologist's discretion Be asked about their pain levels in the recovery area Keep a diary of pain and opioid usage over the first 2 days after surgery conditions: ... |
<|newrecord|> nctId: NCT06351202 id: RBGP 2023 COLNE id: 2023-A02256-39 type: OTHER domain: ANSM briefTitle: Impact Assessment of Abdominal Massage on Feeding Tolerance of Preterms acronym: PREMABDO overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-02 date: 2026-06 date: 2024-04-08 date: 2024-04-10 name: Unive... |
At the Clermont-Ferrand University Hospital Center, abdominal massages have been performed by physiotherapist for several years in order to improve the state of the digestive system of preterm infants. The indication for abdominal massages are very dependent on the caregivers in charge of the newborns because the evalu... |
In this context, the investigators carried out a first study to validate a scale that they created (ECAP scale : Clinical Assessment Scale for Abdominal state of Preterm infant) to assess in a rapid, reliable and reproductible manner the abdominal state of preterm infant - data currently being published). This scale ca... |
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