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Rapid onset of quetiapine-induced diabetic ketoacidosis in an elderly patient: a case report.
|
[
{
"ade": "diabetic ketoacidosis",
"drug": "quetiapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Rapid onset of quetiapine-induced diabetic ketoacidosis in an elderly patient: a case report.",
"role": "user"
},
{
"content": "[{'ade': 'diabetic ketoacidosis', 'drug': 'quetiapine'}]",
"role": "assistant"
}
] |
CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy.
|
[
{
"ade": "rhabdomyolysis",
"drug": "sertraline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy.",
"role": "user"
},
{
"content": "[{'ade': 'rhabdomyolysis', 'drug': 'sertraline'}]",
"role": "assistant"
}
] |
The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome.
|
[
{
"ade": "nephrotic syndrome",
"drug": "M-CSF"
},
{
"ade": "renal disease",
"drug": "M-CSF"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'nephrotic syndrome', 'drug': 'M-CSF'}, {'ade': 'renal disease', 'drug': 'M-CSF'}]",
"role": "assistant"
}
] |
Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.
|
[
{
"ade": "Fulminant hepatitis",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.",
"role": "user"
},
{
"content": "[{'ade': 'Fulminant hepatitis', 'drug': 'propylthiouracil'}]",
"role": "assistant"
}
] |
Since 1979, over 30 published case reports have documented the relationship between phenylpropanolamine and stroke.
|
[
{
"ade": "stroke",
"drug": "phenylpropanolamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Since 1979, over 30 published case reports have documented the relationship between phenylpropanolamine and stroke.",
"role": "user"
},
{
"content": "[{'ade': 'stroke', 'drug': 'phenylpropanolamine'}]",
"role": "assistant"
}
] |
On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.
|
[
{
"ade": "bullous lesions on the hands and soles that disseminated, evolving to necrosis",
"drug": "ARA-C"
},
{
"ade": "sepsis",
"drug": "ARA-C"
},
{
"ade": "death",
"drug": "ARA-C"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.",
"role": "user"
},
{
"content": "[{'ade': 'bullous lesions on the hands and soles that disseminated, evolving to necrosis', 'drug': 'ARA-C'}, {'ade': 'sepsis', 'drug': 'ARA-C'}, {'ade': 'death', 'drug': 'ARA-C'}]",
"role": "assistant"
}
] |
Regression of thyrotoxic ophthalmopathy following lithium withdrawal.
|
[
{
"ade": "thyrotoxic ophthalmopathy",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Regression of thyrotoxic ophthalmopathy following lithium withdrawal.",
"role": "user"
},
{
"content": "[{'ade': 'thyrotoxic ophthalmopathy', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Ampicillin-induced interstitial nephritis with generalised exfoliative dermatitis.
|
[
{
"ade": "interstitial nephritis",
"drug": "Ampicillin"
},
{
"ade": "generalised exfoliative dermatitis",
"drug": "Ampicillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ampicillin-induced interstitial nephritis with generalised exfoliative dermatitis.",
"role": "user"
},
{
"content": "[{'ade': 'interstitial nephritis', 'drug': 'Ampicillin'}, {'ade': 'generalised exfoliative dermatitis', 'drug': 'Ampicillin'}]",
"role": "assistant"
}
] |
Acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia: a case report.
|
[
{
"ade": "Acute unilateral total visual loss",
"drug": "phenol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia: a case report.",
"role": "user"
},
{
"content": "[{'ade': 'Acute unilateral total visual loss', 'drug': 'phenol'}]",
"role": "assistant"
}
] |
He had also developed elevated serum ammonia levels while on valproic acid.
|
[
{
"ade": "elevated serum ammonia levels",
"drug": "valproic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: He had also developed elevated serum ammonia levels while on valproic acid.",
"role": "user"
},
{
"content": "[{'ade': 'elevated serum ammonia levels', 'drug': 'valproic acid'}]",
"role": "assistant"
}
] |
We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.
|
[
{
"ade": "systemic lupus erythematosus",
"drug": "griseofulvin"
},
{
"ade": "nephrotic syndrome",
"drug": "griseofulvin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.",
"role": "user"
},
{
"content": "[{'ade': 'systemic lupus erythematosus', 'drug': 'griseofulvin'}, {'ade': 'nephrotic syndrome', 'drug': 'griseofulvin'}]",
"role": "assistant"
}
] |
Severe symptomatic hyponatremia during sibutramine therapy: a case report.
|
[
{
"ade": "Severe symptomatic hyponatremia",
"drug": "sibutramine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe symptomatic hyponatremia during sibutramine therapy: a case report.",
"role": "user"
},
{
"content": "[{'ade': 'Severe symptomatic hyponatremia', 'drug': 'sibutramine'}]",
"role": "assistant"
}
] |
Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.
|
[
{
"ade": "Myoclonus",
"drug": "L-dopa"
},
{
"ade": "generalized seizures",
"drug": "L-dopa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.",
"role": "user"
},
{
"content": "[{'ade': 'Myoclonus', 'drug': 'L-dopa'}, {'ade': 'generalized seizures', 'drug': 'L-dopa'}]",
"role": "assistant"
}
] |
We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.
|
[
{
"ade": "NEH",
"drug": "mitoxantrone"
},
{
"ade": "NEH",
"drug": "cytarabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.",
"role": "user"
},
{
"content": "[{'ade': 'NEH', 'drug': 'mitoxantrone'}, {'ade': 'NEH', 'drug': 'cytarabine'}]",
"role": "assistant"
}
] |
Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.
|
[
{
"ade": "rhabdomyolysis",
"drug": "cerivastatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.",
"role": "user"
},
{
"content": "[{'ade': 'rhabdomyolysis', 'drug': 'cerivastatin'}]",
"role": "assistant"
}
] |
The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose.
|
[
{
"ade": "t-AML",
"drug": "etoposide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose.",
"role": "user"
},
{
"content": "[{'ade': 't-AML', 'drug': 'etoposide'}]",
"role": "assistant"
}
] |
Ectropion secondary to bolus injection of 5-fluorouracil.
|
[
{
"ade": "Ectropion",
"drug": "5-fluorouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ectropion secondary to bolus injection of 5-fluorouracil.",
"role": "user"
},
{
"content": "[{'ade': 'Ectropion', 'drug': '5-fluorouracil'}]",
"role": "assistant"
}
] |
Red blood cell anemia in a patient with pemphigus vulgaris induced by the use of mycophenolate mofetil and prednisone.
|
[
{
"ade": "Red blood cell anemia",
"drug": "prednisone"
},
{
"ade": "Red blood cell anemia",
"drug": "mycophenolate mofetil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Red blood cell anemia in a patient with pemphigus vulgaris induced by the use of mycophenolate mofetil and prednisone.",
"role": "user"
},
{
"content": "[{'ade': 'Red blood cell anemia', 'drug': 'prednisone'}, {'ade': 'Red blood cell anemia', 'drug': 'mycophenolate mofetil'}]",
"role": "assistant"
}
] |
Depressive symptoms disappeared after interferon therapy was stopped.
|
[
{
"ade": "Depressive symptoms",
"drug": "interferon"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Depressive symptoms disappeared after interferon therapy was stopped.",
"role": "user"
},
{
"content": "[{'ade': 'Depressive symptoms', 'drug': 'interferon'}]",
"role": "assistant"
}
] |
Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.
|
[
{
"ade": "completely bald",
"drug": "levodopa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.",
"role": "user"
},
{
"content": "[{'ade': 'completely bald', 'drug': 'levodopa'}]",
"role": "assistant"
}
] |
However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.
|
[
{
"ade": "liver failure",
"drug": "MTX"
},
{
"ade": "death",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.",
"role": "user"
},
{
"content": "[{'ade': 'liver failure', 'drug': 'MTX'}, {'ade': 'death', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.
|
[
{
"ade": "hypercalcemia",
"drug": "thiazide"
},
{
"ade": "hypercalcemia",
"drug": "vitamin D3"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.",
"role": "user"
},
{
"content": "[{'ade': 'hypercalcemia', 'drug': 'thiazide'}, {'ade': 'hypercalcemia', 'drug': 'vitamin D3'}]",
"role": "assistant"
}
] |
This case demonstrates the value of DWI in evaluation and diagnosis of sub-acute toxic leukoencephalopathy in patients being treated with methotrexate.
|
[
{
"ade": "sub-acute toxic leukoencephalopathy",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case demonstrates the value of DWI in evaluation and diagnosis of sub-acute toxic leukoencephalopathy in patients being treated with methotrexate.",
"role": "user"
},
{
"content": "[{'ade': 'sub-acute toxic leukoencephalopathy', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
A 42 year old man, treated for testicular carcinoma with combination chemotherapy that included bleomycin, developed life threatening interstitial pneumonitis.
|
[
{
"ade": "interstitial pneumonitis",
"drug": "bleomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 42 year old man, treated for testicular carcinoma with combination chemotherapy that included bleomycin, developed life threatening interstitial pneumonitis.",
"role": "user"
},
{
"content": "[{'ade': 'interstitial pneumonitis', 'drug': 'bleomycin'}]",
"role": "assistant"
}
] |
Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.
|
[
{
"ade": "thyrotropin receptor antibody",
"drug": "Amiodarone"
},
{
"ade": "thyrotoxicosis",
"drug": "Amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.",
"role": "user"
},
{
"content": "[{'ade': 'thyrotropin receptor antibody', 'drug': 'Amiodarone'}, {'ade': 'thyrotoxicosis', 'drug': 'Amiodarone'}]",
"role": "assistant"
}
] |
Beginning ductopenia was present in two, suggesting that itraconazole might be responsible for the occurrence of prolonged drug-induced cholangiopathy.
|
[
{
"ade": "cholangiopathy",
"drug": "itraconazole"
},
{
"ade": "ductopenia",
"drug": "itraconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Beginning ductopenia was present in two, suggesting that itraconazole might be responsible for the occurrence of prolonged drug-induced cholangiopathy.",
"role": "user"
},
{
"content": "[{'ade': 'cholangiopathy', 'drug': 'itraconazole'}, {'ade': 'ductopenia', 'drug': 'itraconazole'}]",
"role": "assistant"
}
] |
Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.
|
[
{
"ade": "Reversible corneal keratinization",
"drug": "5-fluorouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.",
"role": "user"
},
{
"content": "[{'ade': 'Reversible corneal keratinization', 'drug': '5-fluorouracil'}]",
"role": "assistant"
}
] |
Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6.
|
[
{
"ade": "hypersensitivity syndrome",
"drug": "Trimethoprim-sulfamethoxazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity syndrome', 'drug': 'Trimethoprim-sulfamethoxazole'}]",
"role": "assistant"
}
] |
A 12 year old patient with atrial flutter is presented, in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia.
|
[
{
"ade": "acceleration of the heart rate",
"drug": "adenosine"
},
{
"ade": "arrhythmia",
"drug": "adenosine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 12 year old patient with atrial flutter is presented, in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia.",
"role": "user"
},
{
"content": "[{'ade': 'acceleration of the heart rate', 'drug': 'adenosine'}, {'ade': 'arrhythmia', 'drug': 'adenosine'}]",
"role": "assistant"
}
] |
Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation.
|
[
{
"ade": "chalazion",
"drug": "Docetaxel"
},
{
"ade": "Meibomian duct inflammation and blockage",
"drug": "Docetaxel"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation.",
"role": "user"
},
{
"content": "[{'ade': 'chalazion', 'drug': 'Docetaxel'}, {'ade': 'Meibomian duct inflammation and blockage', 'drug': 'Docetaxel'}]",
"role": "assistant"
}
] |
Priapism associated with olanzapine.
|
[
{
"ade": "Priapism",
"drug": "olanzapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Priapism associated with olanzapine.",
"role": "user"
},
{
"content": "[{'ade': 'Priapism', 'drug': 'olanzapine'}]",
"role": "assistant"
}
] |
A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.
|
[
{
"ade": "malaise",
"drug": "salazosulfapyridine"
},
{
"ade": "diffuse erythema",
"drug": "salazosulfapyridine"
},
{
"ade": "fever up to 39 degrees C",
"drug": "salazosulfapyridine"
},
{
"ade": "pustules",
"drug": "salazosulfapyridine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.",
"role": "user"
},
{
"content": "[{'ade': 'malaise', 'drug': 'salazosulfapyridine'}, {'ade': 'diffuse erythema', 'drug': 'salazosulfapyridine'}, {'ade': 'fever up to 39 degrees C', 'drug': 'salazosulfapyridine'}, {'ade': 'pustules', 'drug': 'salazosulfapyridine'}]",
"role": "assistant"
}
] |
Two fatal cases of poisoning by paracetamol are described.
|
[
{
"ade": "fatal",
"drug": "paracetamol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two fatal cases of poisoning by paracetamol are described.",
"role": "user"
},
{
"content": "[{'ade': 'fatal', 'drug': 'paracetamol'}]",
"role": "assistant"
}
] |
Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.
|
[
{
"ade": "thrombocytopenia",
"drug": "quinine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'quinine'}]",
"role": "assistant"
}
] |
We report a case of sustained hypotension after administration of parenteral verapamil.
|
[
{
"ade": "sustained hypotension",
"drug": "verapamil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of sustained hypotension after administration of parenteral verapamil.",
"role": "user"
},
{
"content": "[{'ade': 'sustained hypotension', 'drug': 'verapamil'}]",
"role": "assistant"
}
] |
Gelofusine allergy--the need for identification jewellery.
|
[
{
"ade": "Gelofusine allergy",
"drug": "Gelofusine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gelofusine allergy--the need for identification jewellery.",
"role": "user"
},
{
"content": "[{'ade': 'Gelofusine allergy', 'drug': 'Gelofusine'}]",
"role": "assistant"
}
] |
Gold-induced pneumonitis.
|
[
{
"ade": "pneumonitis",
"drug": "Gold"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gold-induced pneumonitis.",
"role": "user"
},
{
"content": "[{'ade': 'pneumonitis', 'drug': 'Gold'}]",
"role": "assistant"
}
] |
In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.
|
[
{
"ade": "deepening of the lid sulcus",
"drug": "bimatoprost"
},
{
"ade": "alteration of eyelid appearance",
"drug": "bimatoprost"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.",
"role": "user"
},
{
"content": "[{'ade': 'deepening of the lid sulcus', 'drug': 'bimatoprost'}, {'ade': 'alteration of eyelid appearance', 'drug': 'bimatoprost'}]",
"role": "assistant"
}
] |
We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.
|
[
{
"ade": "prolonged hypoglycemia",
"drug": "ciprofloxacin"
},
{
"ade": "prolonged hypoglycemia",
"drug": "glyburide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.",
"role": "user"
},
{
"content": "[{'ade': 'prolonged hypoglycemia', 'drug': 'ciprofloxacin'}, {'ade': 'prolonged hypoglycemia', 'drug': 'glyburide'}]",
"role": "assistant"
}
] |
CASE SUMMARY: A 58-year-old white woman developed fulminant liver failure while being treated with the macrolide antibiotic clarithromycin for pneumonia.
|
[
{
"ade": "fulminant liver failure",
"drug": "clarithromycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CASE SUMMARY: A 58-year-old white woman developed fulminant liver failure while being treated with the macrolide antibiotic clarithromycin for pneumonia.",
"role": "user"
},
{
"content": "[{'ade': 'fulminant liver failure', 'drug': 'clarithromycin'}]",
"role": "assistant"
}
] |
We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.
|
[
{
"ade": "thyroiditis",
"drug": "ribavirin"
},
{
"ade": "hyperthryroidism",
"drug": "ribavirin"
},
{
"ade": "thyroiditis",
"drug": "IFN-alpha"
},
{
"ade": "hyperthryroidism",
"drug": "IFN-alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.",
"role": "user"
},
{
"content": "[{'ade': 'thyroiditis', 'drug': 'ribavirin'}, {'ade': 'hyperthryroidism', 'drug': 'ribavirin'}, {'ade': 'thyroiditis', 'drug': 'IFN-alpha'}, {'ade': 'hyperthryroidism', 'drug': 'IFN-alpha'}]",
"role": "assistant"
}
] |
One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).
|
[
{
"ade": "marked cholestasis",
"drug": "clindamycin"
},
{
"ade": "bile duct paucity",
"drug": "clindamycin"
},
{
"ade": "bile duct injury",
"drug": "clindamycin"
},
{
"ade": "portal inflammation",
"drug": "clindamycin"
},
{
"ade": "ductopenia",
"drug": "clindamycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).",
"role": "user"
},
{
"content": "[{'ade': 'marked cholestasis', 'drug': 'clindamycin'}, {'ade': 'bile duct paucity', 'drug': 'clindamycin'}, {'ade': 'bile duct injury', 'drug': 'clindamycin'}, {'ade': 'portal inflammation', 'drug': 'clindamycin'}, {'ade': 'ductopenia', 'drug': 'clindamycin'}]",
"role": "assistant"
}
] |
Carbamazepine-induced systemic lupus erythematosus-like disease.
|
[
{
"ade": "systemic lupus erythematosus-like disease",
"drug": "Carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Carbamazepine-induced systemic lupus erythematosus-like disease.",
"role": "user"
},
{
"content": "[{'ade': 'systemic lupus erythematosus-like disease', 'drug': 'Carbamazepine'}]",
"role": "assistant"
}
] |
We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.
|
[
{
"ade": "secretory carcinoma of the endometrium",
"drug": "tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.",
"role": "user"
},
{
"content": "[{'ade': 'secretory carcinoma of the endometrium', 'drug': 'tamoxifen'}]",
"role": "assistant"
}
] |
Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.
|
[
{
"ade": "tremor",
"drug": "lithium carbonate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.",
"role": "user"
},
{
"content": "[{'ade': 'tremor', 'drug': 'lithium carbonate'}]",
"role": "assistant"
}
] |
We report a male patient with advanced AIDS who developed hypercalcemia 2 weeks after institution of rhGH therapy.
|
[
{
"ade": "hypercalcemia",
"drug": "rhGH"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a male patient with advanced AIDS who developed hypercalcemia 2 weeks after institution of rhGH therapy.",
"role": "user"
},
{
"content": "[{'ade': 'hypercalcemia', 'drug': 'rhGH'}]",
"role": "assistant"
}
] |
Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.
|
[
{
"ade": "Ischaemia",
"drug": "diamorphine"
},
{
"ade": "Ischaemia",
"drug": "methylphenidate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.",
"role": "user"
},
{
"content": "[{'ade': 'Ischaemia', 'drug': 'diamorphine'}, {'ade': 'Ischaemia', 'drug': 'methylphenidate'}]",
"role": "assistant"
}
] |
Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.
|
[
{
"ade": "Systemic lupus erythematosus",
"drug": "penicillamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.",
"role": "user"
},
{
"content": "[{'ade': 'Systemic lupus erythematosus', 'drug': 'penicillamine'}]",
"role": "assistant"
}
] |
The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.
|
[
{
"ade": "vomiting",
"drug": "Viokase"
},
{
"ade": "vomiting",
"drug": "Pancrease MT 16"
},
{
"ade": "vomiting",
"drug": "Creon 10"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.",
"role": "user"
},
{
"content": "[{'ade': 'vomiting', 'drug': 'Viokase'}, {'ade': 'vomiting', 'drug': 'Pancrease MT 16'}, {'ade': 'vomiting', 'drug': 'Creon 10'}]",
"role": "assistant"
}
] |
Generalized lichen nitidus with involvement of the palms following interferon alpha treatment.
|
[
{
"ade": "Generalized lichen nitidus",
"drug": "interferon alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Generalized lichen nitidus with involvement of the palms following interferon alpha treatment.",
"role": "user"
},
{
"content": "[{'ade': 'Generalized lichen nitidus', 'drug': 'interferon alpha'}]",
"role": "assistant"
}
] |
He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.
|
[
{
"ade": "left ventricular dilatation",
"drug": "digoxin"
},
{
"ade": "ventricular fibrillation",
"drug": "digoxin"
},
{
"ade": "functional impairment",
"drug": "digoxin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.",
"role": "user"
},
{
"content": "[{'ade': 'left ventricular dilatation', 'drug': 'digoxin'}, {'ade': 'ventricular fibrillation', 'drug': 'digoxin'}, {'ade': 'functional impairment', 'drug': 'digoxin'}]",
"role": "assistant"
}
] |
Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.
|
[
{
"ade": "death",
"drug": "quinidine"
},
{
"ade": "apnea",
"drug": "quinidine"
},
{
"ade": "bradycardia",
"drug": "verapamil"
},
{
"ade": "sudden death",
"drug": "verapamil"
},
{
"ade": "atrial flutter",
"drug": "verapamil"
},
{
"ade": "long QT interval syndrome",
"drug": "quinidine"
},
{
"ade": "apnea",
"drug": "verapamil"
},
{
"ade": "hypotension",
"drug": "verapamil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with \"familial seizure disorders\" may in fact have the long QT interval syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'death', 'drug': 'quinidine'}, {'ade': 'apnea', 'drug': 'quinidine'}, {'ade': 'bradycardia', 'drug': 'verapamil'}, {'ade': 'sudden death', 'drug': 'verapamil'}, {'ade': 'atrial flutter', 'drug': 'verapamil'}, {'ade': 'long QT interval syndrome', 'drug': 'quinidine'}, {'ade': 'apnea', 'drug': 'verapamil'}, {'ade': 'hypotension', 'drug': 'verapamil'}]",
"role": "assistant"
}
] |
Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.
|
[
{
"ade": "angioneurotic edema",
"drug": "oxcarbazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.",
"role": "user"
},
{
"content": "[{'ade': 'angioneurotic edema', 'drug': 'oxcarbazepine'}]",
"role": "assistant"
}
] |
METHODS/RESULTS: This paper presents a new case of rifabutin uveitis and a review of the various published reports to date.
|
[
{
"ade": "uveitis",
"drug": "rifabutin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: METHODS/RESULTS: This paper presents a new case of rifabutin uveitis and a review of the various published reports to date.",
"role": "user"
},
{
"content": "[{'ade': 'uveitis', 'drug': 'rifabutin'}]",
"role": "assistant"
}
] |
Lamotrigine toxicity secondary to sertraline.
|
[
{
"ade": "Lamotrigine toxicity",
"drug": "Lamotrigine"
},
{
"ade": "Lamotrigine toxicity",
"drug": "sertraline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Lamotrigine toxicity secondary to sertraline.",
"role": "user"
},
{
"content": "[{'ade': 'Lamotrigine toxicity', 'drug': 'Lamotrigine'}, {'ade': 'Lamotrigine toxicity', 'drug': 'sertraline'}]",
"role": "assistant"
}
] |
Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.
|
[
{
"ade": "acute amnestic episode",
"drug": "clioquinol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.",
"role": "user"
},
{
"content": "[{'ade': 'acute amnestic episode', 'drug': 'clioquinol'}]",
"role": "assistant"
}
] |
Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.
|
[
{
"ade": "renal failure",
"drug": "gemcitabine"
},
{
"ade": "Thrombotic microangiopathy",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.",
"role": "user"
},
{
"content": "[{'ade': 'renal failure', 'drug': 'gemcitabine'}, {'ade': 'Thrombotic microangiopathy', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified.
|
[
{
"ade": "nephropathy",
"drug": "gold-salt"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified.",
"role": "user"
},
{
"content": "[{'ade': 'nephropathy', 'drug': 'gold-salt'}]",
"role": "assistant"
}
] |
Although fluoxetine-induced headache occurred in one patient, the other five reported no side effects at the doses used.
|
[
{
"ade": "headache",
"drug": "fluoxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although fluoxetine-induced headache occurred in one patient, the other five reported no side effects at the doses used.",
"role": "user"
},
{
"content": "[{'ade': 'headache', 'drug': 'fluoxetine'}]",
"role": "assistant"
}
] |
Mefloquine-associated hypoglycaemia in a cachectic AIDS patient.
|
[
{
"ade": "hypoglycaemia",
"drug": "Mefloquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Mefloquine-associated hypoglycaemia in a cachectic AIDS patient.",
"role": "user"
},
{
"content": "[{'ade': 'hypoglycaemia', 'drug': 'Mefloquine'}]",
"role": "assistant"
}
] |
Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy.
|
[
{
"ade": "premature ductal closure",
"drug": "indomethacin"
},
{
"ade": "Hypoxia",
"drug": "indomethacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy.",
"role": "user"
},
{
"content": "[{'ade': 'premature ductal closure', 'drug': 'indomethacin'}, {'ade': 'Hypoxia', 'drug': 'indomethacin'}]",
"role": "assistant"
}
] |
Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.
|
[
{
"ade": "Sweet's syndrome",
"drug": "sargramostim"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.",
"role": "user"
},
{
"content": "[{'ade': \"Sweet's syndrome\", 'drug': 'sargramostim'}]",
"role": "assistant"
}
] |
Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.
|
[
{
"ade": "Psychosis",
"drug": "efavirenz"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.",
"role": "user"
},
{
"content": "[{'ade': 'Psychosis', 'drug': 'efavirenz'}]",
"role": "assistant"
}
] |
Long-term follow-up after neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma.
|
[
{
"ade": "neoplastic seeding",
"drug": "ethanol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Long-term follow-up after neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma.",
"role": "user"
},
{
"content": "[{'ade': 'neoplastic seeding', 'drug': 'ethanol'}]",
"role": "assistant"
}
] |
Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.
|
[
{
"ade": "Localized panniculitis",
"drug": "Copaxone"
},
{
"ade": "lipoatrophy",
"drug": "Copaxone"
},
{
"ade": "Localized panniculitis",
"drug": "glatiramer acetate"
},
{
"ade": "lipoatrophy",
"drug": "glatiramer acetate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.",
"role": "user"
},
{
"content": "[{'ade': 'Localized panniculitis', 'drug': 'Copaxone'}, {'ade': 'lipoatrophy', 'drug': 'Copaxone'}, {'ade': 'Localized panniculitis', 'drug': 'glatiramer acetate'}, {'ade': 'lipoatrophy', 'drug': 'glatiramer acetate'}]",
"role": "assistant"
}
] |
Erosion of psoriatic plaques after chronic methotrexate administration.
|
[
{
"ade": "Erosion of psoriatic plaques",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Erosion of psoriatic plaques after chronic methotrexate administration.",
"role": "user"
},
{
"content": "[{'ade': 'Erosion of psoriatic plaques', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.
|
[
{
"ade": "massive pulmonary bleeding",
"drug": "MMC"
},
{
"ade": "HUS",
"drug": "MMC"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.",
"role": "user"
},
{
"content": "[{'ade': 'massive pulmonary bleeding', 'drug': 'MMC'}, {'ade': 'HUS', 'drug': 'MMC'}]",
"role": "assistant"
}
] |
We report the first histopathologically documented case of oral mucosa pigmentation after OLP treatment with topical tacrolimus.
|
[
{
"ade": "oral mucosa pigmentation",
"drug": "tacrolimus"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the first histopathologically documented case of oral mucosa pigmentation after OLP treatment with topical tacrolimus.",
"role": "user"
},
{
"content": "[{'ade': 'oral mucosa pigmentation', 'drug': 'tacrolimus'}]",
"role": "assistant"
}
] |
A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.
|
[
{
"ade": "thrombocytopenia",
"drug": "D-Pen"
},
{
"ade": "anemia",
"drug": "D-penicillamine"
},
{
"ade": "anemia",
"drug": "D-Pen"
},
{
"ade": "thrombocytopenia",
"drug": "D-penicillamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'D-Pen'}, {'ade': 'anemia', 'drug': 'D-penicillamine'}, {'ade': 'anemia', 'drug': 'D-Pen'}, {'ade': 'thrombocytopenia', 'drug': 'D-penicillamine'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Metoclopramide may cause reversible nonthrombocytopenic vascular-type palpable purpura.
|
[
{
"ade": "nonthrombocytopenic vascular-type palpable purpura",
"drug": "Metoclopramide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Metoclopramide may cause reversible nonthrombocytopenic vascular-type palpable purpura.",
"role": "user"
},
{
"content": "[{'ade': 'nonthrombocytopenic vascular-type palpable purpura', 'drug': 'Metoclopramide'}]",
"role": "assistant"
}
] |
Development of Crohn's disease in a patient with multiple sclerosis treated with copaxone.
|
[
{
"ade": "Crohn's disease",
"drug": "copaxone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Development of Crohn's disease in a patient with multiple sclerosis treated with copaxone.",
"role": "user"
},
{
"content": "[{'ade': \"Crohn's disease\", 'drug': 'copaxone'}]",
"role": "assistant"
}
] |
An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.
|
[
{
"ade": "apneic",
"drug": "brimonidine"
},
{
"ade": "lethargic",
"drug": "brimonidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.",
"role": "user"
},
{
"content": "[{'ade': 'apneic', 'drug': 'brimonidine'}, {'ade': 'lethargic', 'drug': 'brimonidine'}]",
"role": "assistant"
}
] |
We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.
|
[
{
"ade": "asthma",
"drug": "captopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.",
"role": "user"
},
{
"content": "[{'ade': 'asthma', 'drug': 'captopril'}]",
"role": "assistant"
}
] |
Doxycycline-induced hypoglycemia in a nondiabetic young man.
|
[
{
"ade": "hypoglycemia",
"drug": "Doxycycline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Doxycycline-induced hypoglycemia in a nondiabetic young man.",
"role": "user"
},
{
"content": "[{'ade': 'hypoglycemia', 'drug': 'Doxycycline'}]",
"role": "assistant"
}
] |
Establishment of diuresis with fluids and IV administration of calcium may provide successful treatment of magnesium toxicosis in horses.
|
[
{
"ade": "magnesium toxicosis",
"drug": "magnesium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Establishment of diuresis with fluids and IV administration of calcium may provide successful treatment of magnesium toxicosis in horses.",
"role": "user"
},
{
"content": "[{'ade': 'magnesium toxicosis', 'drug': 'magnesium'}]",
"role": "assistant"
}
] |
An 8-year-old girl, who had been vaccinated with BCG without subsequent regional reactions, developed osteomyelitis in the left calcaneus 7 months later.
|
[
{
"ade": "osteomyelitis in the left calcaneus",
"drug": "BCG"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: An 8-year-old girl, who had been vaccinated with BCG without subsequent regional reactions, developed osteomyelitis in the left calcaneus 7 months later.",
"role": "user"
},
{
"content": "[{'ade': 'osteomyelitis in the left calcaneus', 'drug': 'BCG'}]",
"role": "assistant"
}
] |
Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts.
|
[
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
Successful challenge with clozapine in a history of eosinophilia.
|
[
{
"ade": "eosinophilia",
"drug": "clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Successful challenge with clozapine in a history of eosinophilia.",
"role": "user"
},
{
"content": "[{'ade': 'eosinophilia', 'drug': 'clozapine'}]",
"role": "assistant"
}
] |
Eleven days after initiation of therapy with amiodarone, the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia.
|
[
{
"ade": "polymorphous ventricular tachycardia",
"drug": "amiodarone"
},
{
"ade": "syncope",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Eleven days after initiation of therapy with amiodarone, the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia.",
"role": "user"
},
{
"content": "[{'ade': 'polymorphous ventricular tachycardia', 'drug': 'amiodarone'}, {'ade': 'syncope', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.
|
[
{
"ade": "weight loss",
"drug": "leflunomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.",
"role": "user"
},
{
"content": "[{'ade': 'weight loss', 'drug': 'leflunomide'}]",
"role": "assistant"
}
] |
These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.
|
[
{
"ade": "production of granulocyte and neutrophil autoantibodies",
"drug": "infliximab"
},
{
"ade": "autoimmune agranulocytosis",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.",
"role": "user"
},
{
"content": "[{'ade': 'production of granulocyte and neutrophil autoantibodies', 'drug': 'infliximab'}, {'ade': 'autoimmune agranulocytosis', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
Lansoprazole-induced thrombocytopenia.
|
[
{
"ade": "thrombocytopenia",
"drug": "Lansoprazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Lansoprazole-induced thrombocytopenia.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'Lansoprazole'}]",
"role": "assistant"
}
] |
AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.
|
[
{
"ade": "stroke",
"drug": "bevacizumab"
},
{
"ade": "acute retinal ischemic change",
"drug": "bevacizumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.",
"role": "user"
},
{
"content": "[{'ade': 'stroke', 'drug': 'bevacizumab'}, {'ade': 'acute retinal ischemic change', 'drug': 'bevacizumab'}]",
"role": "assistant"
}
] |
In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.
|
[
{
"ade": "acute icteric liver necro-inflammation",
"drug": "gliclazide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.",
"role": "user"
},
{
"content": "[{'ade': 'acute icteric liver necro-inflammation', 'drug': 'gliclazide'}]",
"role": "assistant"
}
] |
A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.
|
[
{
"ade": "leukocytopenia",
"drug": "sulfasalazine"
},
{
"ade": "fever",
"drug": "sulfasalazine"
},
{
"ade": "thrombocytopenia",
"drug": "sulfasalazine"
},
{
"ade": "skin eruptions",
"drug": "sulfasalazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.",
"role": "user"
},
{
"content": "[{'ade': 'leukocytopenia', 'drug': 'sulfasalazine'}, {'ade': 'fever', 'drug': 'sulfasalazine'}, {'ade': 'thrombocytopenia', 'drug': 'sulfasalazine'}, {'ade': 'skin eruptions', 'drug': 'sulfasalazine'}]",
"role": "assistant"
}
] |
Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.
|
[
{
"ade": "Polyarthritis",
"drug": "rifampicin"
},
{
"ade": "Polyarthritis",
"drug": "ethambutol"
},
{
"ade": "anti-native DNA antibodies",
"drug": "ethambutol"
},
{
"ade": "hepatitis",
"drug": "ethambutol"
},
{
"ade": "hepatitis",
"drug": "rifampicin"
},
{
"ade": "anti-native DNA antibodies",
"drug": "rifampicin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.",
"role": "user"
},
{
"content": "[{'ade': 'Polyarthritis', 'drug': 'rifampicin'}, {'ade': 'Polyarthritis', 'drug': 'ethambutol'}, {'ade': 'anti-native DNA antibodies', 'drug': 'ethambutol'}, {'ade': 'hepatitis', 'drug': 'ethambutol'}, {'ade': 'hepatitis', 'drug': 'rifampicin'}, {'ade': 'anti-native DNA antibodies', 'drug': 'rifampicin'}]",
"role": "assistant"
}
] |
Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.
|
[
{
"ade": "methemoglobinemia",
"drug": "Benzocaine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.",
"role": "user"
},
{
"content": "[{'ade': 'methemoglobinemia', 'drug': 'Benzocaine'}]",
"role": "assistant"
}
] |
Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.
|
[
{
"ade": "Fatal radiation myelopathy",
"drug": "busulfan"
},
{
"ade": "Fatal radiation myelopathy",
"drug": "melphalan"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.",
"role": "user"
},
{
"content": "[{'ade': 'Fatal radiation myelopathy', 'drug': 'busulfan'}, {'ade': 'Fatal radiation myelopathy', 'drug': 'melphalan'}]",
"role": "assistant"
}
] |
Verapamil in effort-induced angina pectoris in patients with normal coronary arteries.
|
[
{
"ade": "angina pectoris",
"drug": "Verapamil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Verapamil in effort-induced angina pectoris in patients with normal coronary arteries.",
"role": "user"
},
{
"content": "[{'ade': 'angina pectoris', 'drug': 'Verapamil'}]",
"role": "assistant"
}
] |
Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.
|
[
{
"ade": "Putaminal infarct",
"drug": "methanol"
},
{
"ade": "methanol intoxication",
"drug": "methanol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.",
"role": "user"
},
{
"content": "[{'ade': 'Putaminal infarct', 'drug': 'methanol'}, {'ade': 'methanol intoxication', 'drug': 'methanol'}]",
"role": "assistant"
}
] |
Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.
|
[
{
"ade": "LPD",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.",
"role": "user"
},
{
"content": "[{'ade': 'LPD', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.
|
[
{
"ade": "fulminant hepatitis",
"drug": "PTU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.",
"role": "user"
},
{
"content": "[{'ade': 'fulminant hepatitis', 'drug': 'PTU'}]",
"role": "assistant"
}
] |
The day after methotrexate administration, the patient complained of severe back pain and urinary retention.
|
[
{
"ade": "urinary retention",
"drug": "methotrexate"
},
{
"ade": "severe back pain",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The day after methotrexate administration, the patient complained of severe back pain and urinary retention.",
"role": "user"
},
{
"content": "[{'ade': 'urinary retention', 'drug': 'methotrexate'}, {'ade': 'severe back pain', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.
|
[
{
"ade": "reticulate erythema",
"drug": "interferon beta-1b"
},
{
"ade": "painful ulcers",
"drug": "interferon beta-1b"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: 46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.",
"role": "user"
},
{
"content": "[{'ade': 'reticulate erythema', 'drug': 'interferon beta-1b'}, {'ade': 'painful ulcers', 'drug': 'interferon beta-1b'}]",
"role": "assistant"
}
] |
The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.
|
[
{
"ade": "focal segmental glomerulosclerosis",
"drug": "IFNalpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.",
"role": "user"
},
{
"content": "[{'ade': 'focal segmental glomerulosclerosis', 'drug': 'IFNalpha'}]",
"role": "assistant"
}
] |
The most likely cause of such hyponatremic episode is vinblastine.
|
[
{
"ade": "hyponatremic episode",
"drug": "vinblastine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The most likely cause of such hyponatremic episode is vinblastine.",
"role": "user"
},
{
"content": "[{'ade': 'hyponatremic episode', 'drug': 'vinblastine'}]",
"role": "assistant"
}
] |
Visual hallucinations after intravitreal injection of bevacizumab in vascular age-related macular degeneration.
|
[
{
"ade": "Visual hallucinations",
"drug": "bevacizumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Visual hallucinations after intravitreal injection of bevacizumab in vascular age-related macular degeneration.",
"role": "user"
},
{
"content": "[{'ade': 'Visual hallucinations', 'drug': 'bevacizumab'}]",
"role": "assistant"
}
] |
Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy.
|
[
{
"ade": "pneumonitis",
"drug": "Methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy.",
"role": "user"
},
{
"content": "[{'ade': 'pneumonitis', 'drug': 'Methotrexate'}]",
"role": "assistant"
}
] |
L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.
|
[
{
"ade": "posterior reversible encephalopathy",
"drug": "L-asparaginase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.",
"role": "user"
},
{
"content": "[{'ade': 'posterior reversible encephalopathy', 'drug': 'L-asparaginase'}]",
"role": "assistant"
}
] |
One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.
|
[
{
"ade": "hepatic VOD",
"drug": "tacrolimus"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.",
"role": "user"
},
{
"content": "[{'ade': 'hepatic VOD', 'drug': 'tacrolimus'}]",
"role": "assistant"
}
] |
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