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PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.
|
[
{
"ade": "vortex keratopathy",
"drug": "atovaquone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.",
"role": "user"
},
{
"content": "[{'ade': 'vortex keratopathy', 'drug': 'atovaquone'}]",
"role": "assistant"
}
] |
We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus.
|
[
{
"ade": "negative myoclonus",
"drug": "pregabalin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus.",
"role": "user"
},
{
"content": "[{'ade': 'negative myoclonus', 'drug': 'pregabalin'}]",
"role": "assistant"
}
] |
Cis-retinoic acid (RA) may further increase the risk of developing BMTN.
|
[
{
"ade": "BMTN",
"drug": "Cis-retinoic acid"
},
{
"ade": "BMTN",
"drug": "RA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cis-retinoic acid (RA) may further increase the risk of developing BMTN.",
"role": "user"
},
{
"content": "[{'ade': 'BMTN', 'drug': 'Cis-retinoic acid'}, {'ade': 'BMTN', 'drug': 'RA'}]",
"role": "assistant"
}
] |
PURPOSE: Topiramate-induced angle-closure glaucoma (TiACG) is believed to be related to its sulfonamide moiety.
|
[
{
"ade": "angle-closure glaucoma",
"drug": "Topiramate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PURPOSE: Topiramate-induced angle-closure glaucoma (TiACG) is believed to be related to its sulfonamide moiety.",
"role": "user"
},
{
"content": "[{'ade': 'angle-closure glaucoma', 'drug': 'Topiramate'}]",
"role": "assistant"
}
] |
Acute reversible ataxo-myoclonic encephalopathy with flecainide therapy.
|
[
{
"ade": "Acute reversible ataxo-myoclonic encephalopathy",
"drug": "flecainide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute reversible ataxo-myoclonic encephalopathy with flecainide therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Acute reversible ataxo-myoclonic encephalopathy', 'drug': 'flecainide'}]",
"role": "assistant"
}
] |
Intraventricular nafcillin-induced seizures in a neonate.
|
[
{
"ade": "seizures",
"drug": "nafcillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intraventricular nafcillin-induced seizures in a neonate.",
"role": "user"
},
{
"content": "[{'ade': 'seizures', 'drug': 'nafcillin'}]",
"role": "assistant"
}
] |
Three days after intravitreal injection of bevacizumab, acute ocular ischemic syndrome occurred.
|
[
{
"ade": "acute ocular ischemic syndrome",
"drug": "bevacizumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three days after intravitreal injection of bevacizumab, acute ocular ischemic syndrome occurred.",
"role": "user"
},
{
"content": "[{'ade': 'acute ocular ischemic syndrome', 'drug': 'bevacizumab'}]",
"role": "assistant"
}
] |
The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible.
|
[
{
"ade": "RTA",
"drug": "FK506"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible.",
"role": "user"
},
{
"content": "[{'ade': 'RTA', 'drug': 'FK506'}]",
"role": "assistant"
}
] |
Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.
|
[
{
"ade": "nephrogenic diabetes insipidus",
"drug": "lithium"
},
{
"ade": "lithium toxicity",
"drug": "lithium"
},
{
"ade": "polyuria",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.",
"role": "user"
},
{
"content": "[{'ade': 'nephrogenic diabetes insipidus', 'drug': 'lithium'}, {'ade': 'lithium toxicity', 'drug': 'lithium'}, {'ade': 'polyuria', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Hypo-oestrogenic and anabolic/androgenic side-effects of danazol are well known by the gynaecologist and some of them are present in > 50% of patients being treated for endometriosis.
|
[
{
"ade": "Hypo-oestrogenic and anabolic/androgenic side-effects",
"drug": "danazol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hypo-oestrogenic and anabolic/androgenic side-effects of danazol are well known by the gynaecologist and some of them are present in > 50% of patients being treated for endometriosis.",
"role": "user"
},
{
"content": "[{'ade': 'Hypo-oestrogenic and anabolic/androgenic side-effects', 'drug': 'danazol'}]",
"role": "assistant"
}
] |
CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.
|
[
{
"ade": "hypercalcemia",
"drug": "rhGH"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.",
"role": "user"
},
{
"content": "[{'ade': 'hypercalcemia', 'drug': 'rhGH'}]",
"role": "assistant"
}
] |
Akathisia appeared to be a common side effect of fluoxetine and generally responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both.
|
[
{
"ade": "Akathisia",
"drug": "fluoxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Akathisia appeared to be a common side effect of fluoxetine and generally responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both.",
"role": "user"
},
{
"content": "[{'ade': 'Akathisia', 'drug': 'fluoxetine'}]",
"role": "assistant"
}
] |
This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.
|
[
{
"ade": "catatonic syndrome",
"drug": "disulfiram"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.",
"role": "user"
},
{
"content": "[{'ade': 'catatonic syndrome', 'drug': 'disulfiram'}]",
"role": "assistant"
}
] |
Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.
|
[
{
"ade": "Acute myocardial infarction",
"drug": "L-thyroxine"
},
{
"ade": "coronary spasm",
"drug": "L-thyroxine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Acute myocardial infarction', 'drug': 'L-thyroxine'}, {'ade': 'coronary spasm', 'drug': 'L-thyroxine'}]",
"role": "assistant"
}
] |
A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.
|
[
{
"ade": "retroperitoneal fibrosis",
"drug": "methysergide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.",
"role": "user"
},
{
"content": "[{'ade': 'retroperitoneal fibrosis', 'drug': 'methysergide'}]",
"role": "assistant"
}
] |
Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades.
|
[
{
"ade": "Sensorineural hearing loss",
"drug": "quinine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades.",
"role": "user"
},
{
"content": "[{'ade': 'Sensorineural hearing loss', 'drug': 'quinine'}]",
"role": "assistant"
}
] |
Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.
|
[
{
"ade": "Hepatitis",
"drug": "methotrexate"
},
{
"ade": "bridging fibrosis",
"drug": "methotrexate"
},
{
"ade": "reversible hepatic insufficiency",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.",
"role": "user"
},
{
"content": "[{'ade': 'Hepatitis', 'drug': 'methotrexate'}, {'ade': 'bridging fibrosis', 'drug': 'methotrexate'}, {'ade': 'reversible hepatic insufficiency', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively.
|
[
{
"ade": "sensory neuropathy",
"drug": "metronidazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively.",
"role": "user"
},
{
"content": "[{'ade': 'sensory neuropathy', 'drug': 'metronidazole'}]",
"role": "assistant"
}
] |
OBJECTIVE: To describe a probable case of transient global amnesia caused by propafenone.
|
[
{
"ade": "transient global amnesia",
"drug": "propafenone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To describe a probable case of transient global amnesia caused by propafenone.",
"role": "user"
},
{
"content": "[{'ade': 'transient global amnesia', 'drug': 'propafenone'}]",
"role": "assistant"
}
] |
We report a patient who developed acute pancreatitis during amiodarone therapy.
|
[
{
"ade": "acute pancreatitis",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a patient who developed acute pancreatitis during amiodarone therapy.",
"role": "user"
},
{
"content": "[{'ade': 'acute pancreatitis', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
The dose-limiting toxicity of KW-2149 is pulmonary toxicity.
|
[
{
"ade": "pulmonary toxicity",
"drug": "KW-2149"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The dose-limiting toxicity of KW-2149 is pulmonary toxicity.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary toxicity', 'drug': 'KW-2149'}]",
"role": "assistant"
}
] |
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.
|
[
{
"ade": "transient thyrotoxicosis",
"drug": "interferon"
},
{
"ade": "Graves' hyperthyroidism",
"drug": "interferon"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.",
"role": "user"
},
{
"content": "[{'ade': 'transient thyrotoxicosis', 'drug': 'interferon'}, {'ade': \"Graves' hyperthyroidism\", 'drug': 'interferon'}]",
"role": "assistant"
}
] |
Severe systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapy.
|
[
{
"ade": "Severe systemic hypersensitivity reaction",
"drug": "ibuprofen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Severe systemic hypersensitivity reaction', 'drug': 'ibuprofen'}]",
"role": "assistant"
}
] |
Cyclophosphamide pneumonitis.
|
[
{
"ade": "pneumonitis",
"drug": "Cyclophosphamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cyclophosphamide pneumonitis.",
"role": "user"
},
{
"content": "[{'ade': 'pneumonitis', 'drug': 'Cyclophosphamide'}]",
"role": "assistant"
}
] |
Paralytic ileus in patients undergoing bortezomib treatment has been reported, although a definite attribution to bortezomib administration has not been established.
|
[
{
"ade": "Paralytic ileus",
"drug": "bortezomib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Paralytic ileus in patients undergoing bortezomib treatment has been reported, although a definite attribution to bortezomib administration has not been established.",
"role": "user"
},
{
"content": "[{'ade': 'Paralytic ileus', 'drug': 'bortezomib'}]",
"role": "assistant"
}
] |
The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures.
|
[
{
"ade": "teratogenicity",
"drug": "methimazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures.",
"role": "user"
},
{
"content": "[{'ade': 'teratogenicity', 'drug': 'methimazole'}]",
"role": "assistant"
}
] |
Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.
|
[
{
"ade": "temporary amnesia",
"drug": "propranolol"
},
{
"ade": "disorientation",
"drug": "propranolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.",
"role": "user"
},
{
"content": "[{'ade': 'temporary amnesia', 'drug': 'propranolol'}, {'ade': 'disorientation', 'drug': 'propranolol'}]",
"role": "assistant"
}
] |
This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.
|
[
{
"ade": "hepatic decompensation",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.",
"role": "user"
},
{
"content": "[{'ade': 'hepatic decompensation', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.
|
[
{
"ade": "HUS",
"drug": "mitomycin C"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.",
"role": "user"
},
{
"content": "[{'ade': 'HUS', 'drug': 'mitomycin C'}]",
"role": "assistant"
}
] |
Codeine intoxication in the neonate.
|
[
{
"ade": "Codeine intoxication",
"drug": "Codeine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Codeine intoxication in the neonate.",
"role": "user"
},
{
"content": "[{'ade': 'Codeine intoxication', 'drug': 'Codeine'}]",
"role": "assistant"
}
] |
Transient hemiparesis caused by phenytoin toxicity.
|
[
{
"ade": "Transient hemiparesis",
"drug": "phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Transient hemiparesis caused by phenytoin toxicity.",
"role": "user"
},
{
"content": "[{'ade': 'Transient hemiparesis', 'drug': 'phenytoin'}]",
"role": "assistant"
}
] |
The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.
|
[
{
"ade": "eosinophilic pneumonia reaction",
"drug": "beclomethasone diproprionate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.",
"role": "user"
},
{
"content": "[{'ade': 'eosinophilic pneumonia reaction', 'drug': 'beclomethasone diproprionate'}]",
"role": "assistant"
}
] |
This report describes the first case of insulin-induced cardiac failure in a patient without underlying heart disease.
|
[
{
"ade": "cardiac failure",
"drug": "insulin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report describes the first case of insulin-induced cardiac failure in a patient without underlying heart disease.",
"role": "user"
},
{
"content": "[{'ade': 'cardiac failure', 'drug': 'insulin'}]",
"role": "assistant"
}
] |
Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.
|
[
{
"ade": "Clinical, spectroscopic, and imaging abnormalities",
"drug": "metronidazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.",
"role": "user"
},
{
"content": "[{'ade': 'Clinical, spectroscopic, and imaging abnormalities', 'drug': 'metronidazole'}]",
"role": "assistant"
}
] |
Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.
|
[
{
"ade": "Mucosal pigmentation",
"drug": "tacrolimus"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.",
"role": "user"
},
{
"content": "[{'ade': 'Mucosal pigmentation', 'drug': 'tacrolimus'}]",
"role": "assistant"
}
] |
We describe a 15-year-old female patient diagnosed with acute lymphoblastic leukemia presenting with status epilepticus after receiving intrathecal methotrexate.
|
[
{
"ade": "acute lymphoblastic leukemia",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a 15-year-old female patient diagnosed with acute lymphoblastic leukemia presenting with status epilepticus after receiving intrathecal methotrexate.",
"role": "user"
},
{
"content": "[{'ade': 'acute lymphoblastic leukemia', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Captopril-induced lichen planus pemphigoides with pemphigus-like features.
|
[
{
"ade": "lichen planus pemphigoides",
"drug": "Captopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Captopril-induced lichen planus pemphigoides with pemphigus-like features.",
"role": "user"
},
{
"content": "[{'ade': 'lichen planus pemphigoides', 'drug': 'Captopril'}]",
"role": "assistant"
}
] |
Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.
|
[
{
"ade": "seizures",
"drug": "ampicillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.",
"role": "user"
},
{
"content": "[{'ade': 'seizures', 'drug': 'ampicillin'}]",
"role": "assistant"
}
] |
Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.
|
[
{
"ade": "obsessive-compulsive symptoms",
"drug": "Quetiapine"
},
{
"ade": "OCS",
"drug": "Quetiapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.",
"role": "user"
},
{
"content": "[{'ade': 'obsessive-compulsive symptoms', 'drug': 'Quetiapine'}, {'ade': 'OCS', 'drug': 'Quetiapine'}]",
"role": "assistant"
}
] |
In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.
|
[
{
"ade": "dyspnea",
"drug": "lenalidomide"
},
{
"ade": "hypoxia",
"drug": "lenalidomide"
},
{
"ade": "fever",
"drug": "lenalidomide"
},
{
"ade": "diffuse pulmonary infiltrates",
"drug": "lenalidomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.",
"role": "user"
},
{
"content": "[{'ade': 'dyspnea', 'drug': 'lenalidomide'}, {'ade': 'hypoxia', 'drug': 'lenalidomide'}, {'ade': 'fever', 'drug': 'lenalidomide'}, {'ade': 'diffuse pulmonary infiltrates', 'drug': 'lenalidomide'}]",
"role": "assistant"
}
] |
DISCUSSION: Colchicine, the most important drug in treatment of FMF, can cause myopathy in patients with impaired renal and hepatic function.
|
[
{
"ade": "myopathy",
"drug": "Colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: DISCUSSION: Colchicine, the most important drug in treatment of FMF, can cause myopathy in patients with impaired renal and hepatic function.",
"role": "user"
},
{
"content": "[{'ade': 'myopathy', 'drug': 'Colchicine'}]",
"role": "assistant"
}
] |
Radiation recall related to gemcitabine has been reported in lung and breast cancer.
|
[
{
"ade": "Radiation recall",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Radiation recall related to gemcitabine has been reported in lung and breast cancer.",
"role": "user"
},
{
"content": "[{'ade': 'Radiation recall', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
Asthma and urticaria during disodium cromoglycate treatment.
|
[
{
"ade": "urticaria",
"drug": "disodium cromoglycate"
},
{
"ade": "Asthma",
"drug": "disodium cromoglycate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Asthma and urticaria during disodium cromoglycate treatment.",
"role": "user"
},
{
"content": "[{'ade': 'urticaria', 'drug': 'disodium cromoglycate'}, {'ade': 'Asthma', 'drug': 'disodium cromoglycate'}]",
"role": "assistant"
}
] |
We report a case of amiodarone-induced thyrotoxicosis of protracted duration, unresponsive to conventional thionamide therapy, with therapy limited by severe adverse drug reactions.
|
[
{
"ade": "thyrotoxicosis",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of amiodarone-induced thyrotoxicosis of protracted duration, unresponsive to conventional thionamide therapy, with therapy limited by severe adverse drug reactions.",
"role": "user"
},
{
"content": "[{'ade': 'thyrotoxicosis', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.
|
[
{
"ade": "colitis",
"drug": "rofecoxib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.",
"role": "user"
},
{
"content": "[{'ade': 'colitis', 'drug': 'rofecoxib'}]",
"role": "assistant"
}
] |
A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.
|
[
{
"ade": "type 1 diabetes mellitus",
"drug": "ribavirin"
},
{
"ade": "type 1 diabetes mellitus",
"drug": "alpha-2b peginterferon"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.",
"role": "user"
},
{
"content": "[{'ade': 'type 1 diabetes mellitus', 'drug': 'ribavirin'}, {'ade': 'type 1 diabetes mellitus', 'drug': 'alpha-2b peginterferon'}]",
"role": "assistant"
}
] |
A case of skeletal fluorosis induced by prolonged treatment with niflumic acid, a fast-acting non-steroid antiinflammatory agent, is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated, in addition, with corticosteroids.
|
[
{
"ade": "skeletal fluorosis",
"drug": "niflumic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of skeletal fluorosis induced by prolonged treatment with niflumic acid, a fast-acting non-steroid antiinflammatory agent, is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated, in addition, with corticosteroids.",
"role": "user"
},
{
"content": "[{'ade': 'skeletal fluorosis', 'drug': 'niflumic acid'}]",
"role": "assistant"
}
] |
Subsequently, he developed hyperglycemia (fasting blood glucose 138 mg/dL) that resolved when olanzapine was stopped and recurred (fasting blood glucose 150 mg/dL) after 2 days of rechallenge with olanzapine 2.5 mg twice daily.
|
[
{
"ade": "hyperglycemia",
"drug": "olanzapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Subsequently, he developed hyperglycemia (fasting blood glucose 138 mg/dL) that resolved when olanzapine was stopped and recurred (fasting blood glucose 150 mg/dL) after 2 days of rechallenge with olanzapine 2.5 mg twice daily.",
"role": "user"
},
{
"content": "[{'ade': 'hyperglycemia', 'drug': 'olanzapine'}]",
"role": "assistant"
}
] |
The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.
|
[
{
"ade": "hyponatremia",
"drug": "caffeine"
},
{
"ade": "delirium",
"drug": "caffeine"
},
{
"ade": "rhabdomyolysis",
"drug": "caffeine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.",
"role": "user"
},
{
"content": "[{'ade': 'hyponatremia', 'drug': 'caffeine'}, {'ade': 'delirium', 'drug': 'caffeine'}, {'ade': 'rhabdomyolysis', 'drug': 'caffeine'}]",
"role": "assistant"
}
] |
Can propofol precipitate pancreatitis in patients with Cushing's syndrome?
|
[
{
"ade": "pancreatitis",
"drug": "propofol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Can propofol precipitate pancreatitis in patients with Cushing's syndrome?",
"role": "user"
},
{
"content": "[{'ade': 'pancreatitis', 'drug': 'propofol'}]",
"role": "assistant"
}
] |
OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.
|
[
{
"ade": "disfiguring facial edema",
"drug": "ribavirin"
},
{
"ade": "disfiguring facial edema",
"drug": "peginterferon alfa-2a"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.",
"role": "user"
},
{
"content": "[{'ade': 'disfiguring facial edema', 'drug': 'ribavirin'}, {'ade': 'disfiguring facial edema', 'drug': 'peginterferon alfa-2a'}]",
"role": "assistant"
}
] |
Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.
|
[
{
"ade": "Reye-like syndrome",
"drug": "calcium hopantenate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.",
"role": "user"
},
{
"content": "[{'ade': 'Reye-like syndrome', 'drug': 'calcium hopantenate'}]",
"role": "assistant"
}
] |
This article describes the case of a 25-year-old man found dead at home who had been prescribed olanzapine for schizophrenia.
|
[
{
"ade": "dead",
"drug": "olanzapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This article describes the case of a 25-year-old man found dead at home who had been prescribed olanzapine for schizophrenia.",
"role": "user"
},
{
"content": "[{'ade': 'dead', 'drug': 'olanzapine'}]",
"role": "assistant"
}
] |
Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.
|
[
{
"ade": "decreased sensation of vibration",
"drug": "recombinant interferon alpha-2a"
},
{
"ade": "bilateral optic neuritis",
"drug": "recombinant interferon alpha-2a"
},
{
"ade": "increased deep tendon reflex",
"drug": "recombinant interferon alpha-2a"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.",
"role": "user"
},
{
"content": "[{'ade': 'decreased sensation of vibration', 'drug': 'recombinant interferon alpha-2a'}, {'ade': 'bilateral optic neuritis', 'drug': 'recombinant interferon alpha-2a'}, {'ade': 'increased deep tendon reflex', 'drug': 'recombinant interferon alpha-2a'}]",
"role": "assistant"
}
] |
Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.
|
[
{
"ade": "Extensive forearm deep venous thrombosis",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.",
"role": "user"
},
{
"content": "[{'ade': 'Extensive forearm deep venous thrombosis', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
Metronidazole neuropathy.
|
[
{
"ade": "neuropathy",
"drug": "Metronidazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Metronidazole neuropathy.",
"role": "user"
},
{
"content": "[{'ade': 'neuropathy', 'drug': 'Metronidazole'}]",
"role": "assistant"
}
] |
Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.
|
[
{
"ade": "neurotoxicity",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'neurotoxicity', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.
|
[
{
"ade": "leukoencephalopathy",
"drug": "methotrexate"
},
{
"ade": "hydrocephalus",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.",
"role": "user"
},
{
"content": "[{'ade': 'leukoencephalopathy', 'drug': 'methotrexate'}, {'ade': 'hydrocephalus', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Propecia-associated bilateral cataract.
|
[
{
"ade": "bilateral cataract",
"drug": "Propecia"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Propecia-associated bilateral cataract.",
"role": "user"
},
{
"content": "[{'ade': 'bilateral cataract', 'drug': 'Propecia'}]",
"role": "assistant"
}
] |
Subcutaneous IL-2 is safe and well tolerated, with a mortality rate <3%.
|
[
{
"ade": "mortality rate <3",
"drug": "IL-2"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Subcutaneous IL-2 is safe and well tolerated, with a mortality rate <3%.",
"role": "user"
},
{
"content": "[{'ade': 'mortality rate <3', 'drug': 'IL-2'}]",
"role": "assistant"
}
] |
Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.
|
[
{
"ade": "Spontaneous hemothorax",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.",
"role": "user"
},
{
"content": "[{'ade': 'Spontaneous hemothorax', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
Colchicine-induced rhabdomyolysis.
|
[
{
"ade": "rhabdomyolysis",
"drug": "Colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Colchicine-induced rhabdomyolysis.",
"role": "user"
},
{
"content": "[{'ade': 'rhabdomyolysis', 'drug': 'Colchicine'}]",
"role": "assistant"
}
] |
To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.
|
[
{
"ade": "TEN",
"drug": "lamotrigine"
},
{
"ade": "SJS",
"drug": "lamotrigine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.",
"role": "user"
},
{
"content": "[{'ade': 'TEN', 'drug': 'lamotrigine'}, {'ade': 'SJS', 'drug': 'lamotrigine'}]",
"role": "assistant"
}
] |
Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.
|
[
{
"ade": "Arrhythmias",
"drug": "amphotericin B"
},
{
"ade": "cardiac arrest",
"drug": "amphotericin B"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.",
"role": "user"
},
{
"content": "[{'ade': 'Arrhythmias', 'drug': 'amphotericin B'}, {'ade': 'cardiac arrest', 'drug': 'amphotericin B'}]",
"role": "assistant"
}
] |
A patient with the Wolff-Parkinson-White syndrome presented with incessant orthodromic atrioventricular tachycardia following initiation of procainamide therapy.
|
[
{
"ade": "incessant orthodromic atrioventricular tachycardia",
"drug": "procainamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient with the Wolff-Parkinson-White syndrome presented with incessant orthodromic atrioventricular tachycardia following initiation of procainamide therapy.",
"role": "user"
},
{
"content": "[{'ade': 'incessant orthodromic atrioventricular tachycardia', 'drug': 'procainamide'}]",
"role": "assistant"
}
] |
Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.
|
[
{
"ade": "alterations in heart rate",
"drug": "adenosine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.",
"role": "user"
},
{
"content": "[{'ade': 'alterations in heart rate', 'drug': 'adenosine'}]",
"role": "assistant"
}
] |
The authors suggest that risperidone may increase affect in patients with schizophrenia and that some patients, especially those with anxiety, may have difficulty managing the increase.
|
[
{
"ade": "increase affect",
"drug": "risperidone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors suggest that risperidone may increase affect in patients with schizophrenia and that some patients, especially those with anxiety, may have difficulty managing the increase.",
"role": "user"
},
{
"content": "[{'ade': 'increase affect', 'drug': 'risperidone'}]",
"role": "assistant"
}
] |
After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.
|
[
{
"ade": "anisocoria",
"drug": "scopolamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.",
"role": "user"
},
{
"content": "[{'ade': 'anisocoria', 'drug': 'scopolamine'}]",
"role": "assistant"
}
] |
Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.
|
[
{
"ade": "neurologic deterioration",
"drug": "nitrous oxide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.",
"role": "user"
},
{
"content": "[{'ade': 'neurologic deterioration', 'drug': 'nitrous oxide'}]",
"role": "assistant"
}
] |
We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.
|
[
{
"ade": "interstitial pulmonary disease",
"drug": "ticlopidine"
},
{
"ade": "lymphocytic colitis",
"drug": "ticlopidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.",
"role": "user"
},
{
"content": "[{'ade': 'interstitial pulmonary disease', 'drug': 'ticlopidine'}, {'ade': 'lymphocytic colitis', 'drug': 'ticlopidine'}]",
"role": "assistant"
}
] |
A woman 38-year-old, suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo-Medrol, developed a spastic paraparesis at the lower limbs.
|
[
{
"ade": "spastic paraparesis at the lower limbs",
"drug": "Depo-Medrol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A woman 38-year-old, suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo-Medrol, developed a spastic paraparesis at the lower limbs.",
"role": "user"
},
{
"content": "[{'ade': 'spastic paraparesis at the lower limbs', 'drug': 'Depo-Medrol'}]",
"role": "assistant"
}
] |
After cessation of amantadine, the edema resolved, and the endothelial cell densities were <or=600/mm.
|
[
{
"ade": "edema",
"drug": "amantadine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After cessation of amantadine, the edema resolved, and the endothelial cell densities were <or=600/mm.",
"role": "user"
},
{
"content": "[{'ade': 'edema', 'drug': 'amantadine'}]",
"role": "assistant"
}
] |
We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.
|
[
{
"ade": "PSA continued to decrease",
"drug": "flutamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.",
"role": "user"
},
{
"content": "[{'ade': 'PSA continued to decrease', 'drug': 'flutamide'}]",
"role": "assistant"
}
] |
After four months, while receiving RH, he developed painful bilateral gynaecomastia.
|
[
{
"ade": "bilateral gynaecomastia",
"drug": "RH"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After four months, while receiving RH, he developed painful bilateral gynaecomastia.",
"role": "user"
},
{
"content": "[{'ade': 'bilateral gynaecomastia', 'drug': 'RH'}]",
"role": "assistant"
}
] |
Since tamoxifen therapy can induce endometrial disorders, surveillance schemes of women taking tamoxifen have been recommended.
|
[
{
"ade": "endometrial disorders",
"drug": "tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Since tamoxifen therapy can induce endometrial disorders, surveillance schemes of women taking tamoxifen have been recommended.",
"role": "user"
},
{
"content": "[{'ade': 'endometrial disorders', 'drug': 'tamoxifen'}]",
"role": "assistant"
}
] |
Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis.
|
[
{
"ade": "lymphoproliferative disorder",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis.",
"role": "user"
},
{
"content": "[{'ade': 'lymphoproliferative disorder', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
Myotonia associated with sarcoidosis: marked exacerbation with pravastatin.
|
[
{
"ade": "Myotonia",
"drug": "pravastatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Myotonia associated with sarcoidosis: marked exacerbation with pravastatin.",
"role": "user"
},
{
"content": "[{'ade': 'Myotonia', 'drug': 'pravastatin'}]",
"role": "assistant"
}
] |
The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.
|
[
{
"ade": "irritant type of reaction",
"drug": "calcipotriol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.",
"role": "user"
},
{
"content": "[{'ade': 'irritant type of reaction', 'drug': 'calcipotriol'}]",
"role": "assistant"
}
] |
Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.
|
[
{
"ade": "purple discoloration",
"drug": "phenytoin"
},
{
"ade": "swelling of the hands",
"drug": "phenytoin"
},
{
"ade": "Purple glove syndrome",
"drug": "phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.",
"role": "user"
},
{
"content": "[{'ade': 'purple discoloration', 'drug': 'phenytoin'}, {'ade': 'swelling of the hands', 'drug': 'phenytoin'}, {'ade': 'Purple glove syndrome', 'drug': 'phenytoin'}]",
"role": "assistant"
}
] |
Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.
|
[
{
"ade": "metabolic acidosis",
"drug": "formic acid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.",
"role": "user"
},
{
"content": "[{'ade': 'metabolic acidosis', 'drug': 'formic acid'}]",
"role": "assistant"
}
] |
Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin.
|
[
{
"ade": "porphyria",
"drug": "diphenylhydantoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin.",
"role": "user"
},
{
"content": "[{'ade': 'porphyria', 'drug': 'diphenylhydantoin'}]",
"role": "assistant"
}
] |
It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.
|
[
{
"ade": "sulphasalazine syndrome",
"drug": "sulphasalazine"
},
{
"ade": "fatal",
"drug": "sulphasalazine"
},
{
"ade": "immunoallergic reaction",
"drug": "sulphasalazine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called \"3-week sulphasalazine syndrome\", a rare, but often fatal, immunoallergic reaction to sulphasalazine.",
"role": "user"
},
{
"content": "[{'ade': 'sulphasalazine syndrome', 'drug': 'sulphasalazine'}, {'ade': 'fatal', 'drug': 'sulphasalazine'}, {'ade': 'immunoallergic reaction', 'drug': 'sulphasalazine'}]",
"role": "assistant"
}
] |
Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.
|
[
{
"ade": "Diarrhoea",
"drug": "oxaliplatinum"
},
{
"ade": "Diarrhoea",
"drug": "5-fluorouracil"
},
{
"ade": "T-CD4+ lymphopenia",
"drug": "5-fluorouracil"
},
{
"ade": "T-CD4+ lymphopenia",
"drug": "oxaliplatinum"
},
{
"ade": "bilateral patchy pulmonary infiltrates",
"drug": "oxaliplatinum"
},
{
"ade": "bilateral patchy pulmonary infiltrates",
"drug": "5-fluorouracil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.",
"role": "user"
},
{
"content": "[{'ade': 'Diarrhoea', 'drug': 'oxaliplatinum'}, {'ade': 'Diarrhoea', 'drug': '5-fluorouracil'}, {'ade': 'T-CD4+ lymphopenia', 'drug': '5-fluorouracil'}, {'ade': 'T-CD4+ lymphopenia', 'drug': 'oxaliplatinum'}, {'ade': 'bilateral patchy pulmonary infiltrates', 'drug': 'oxaliplatinum'}, {'ade': 'bilateral patchy pulmonary infiltrates', 'drug': '5-fluorouracil'}]",
"role": "assistant"
}
] |
Baclofen withdrawal: a cause of prolonged fever in the intensive care unit.
|
[
{
"ade": "fever",
"drug": "Baclofen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Baclofen withdrawal: a cause of prolonged fever in the intensive care unit.",
"role": "user"
},
{
"content": "[{'ade': 'fever', 'drug': 'Baclofen'}]",
"role": "assistant"
}
] |
CONCLUSION: The administration of tissue plasminogen activator was responsible for the large extent of hemorrhage and should be considered in the differential diagnosis of hemorrhagic choroidal detachment.
|
[
{
"ade": "hemorrhagic choroidal detachment",
"drug": "tissue plasminogen activator"
},
{
"ade": "hemorrhage",
"drug": "tissue plasminogen activator"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: The administration of tissue plasminogen activator was responsible for the large extent of hemorrhage and should be considered in the differential diagnosis of hemorrhagic choroidal detachment.",
"role": "user"
},
{
"content": "[{'ade': 'hemorrhagic choroidal detachment', 'drug': 'tissue plasminogen activator'}, {'ade': 'hemorrhage', 'drug': 'tissue plasminogen activator'}]",
"role": "assistant"
}
] |
Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.
|
[
{
"ade": "impaired tissue perfusion",
"drug": "vasopressin"
},
{
"ade": "vasodilation",
"drug": "vasopressin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.",
"role": "user"
},
{
"content": "[{'ade': 'impaired tissue perfusion', 'drug': 'vasopressin'}, {'ade': 'vasodilation', 'drug': 'vasopressin'}]",
"role": "assistant"
}
] |
Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.
|
[
{
"ade": "Fatal intravascular autoimmune hemolytic anemia",
"drug": "fludarabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.",
"role": "user"
},
{
"content": "[{'ade': 'Fatal intravascular autoimmune hemolytic anemia', 'drug': 'fludarabine'}]",
"role": "assistant"
}
] |
One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.
|
[
{
"ade": "Staphylococcus aureus knee arthritis",
"drug": "sodium hyaluronate"
},
{
"ade": "Staphylococcus aureus knee arthritis",
"drug": "corticosteroids"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.",
"role": "user"
},
{
"content": "[{'ade': 'Staphylococcus aureus knee arthritis', 'drug': 'sodium hyaluronate'}, {'ade': 'Staphylococcus aureus knee arthritis', 'drug': 'corticosteroids'}]",
"role": "assistant"
}
] |
High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer.
|
[
{
"ade": "High-grade endometrial stromal sarcoma",
"drug": "tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer.",
"role": "user"
},
{
"content": "[{'ade': 'High-grade endometrial stromal sarcoma', 'drug': 'tamoxifen'}]",
"role": "assistant"
}
] |
Psychotic disorder associated with isoniazid.
|
[
{
"ade": "Psychotic disorder",
"drug": "isoniazid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Psychotic disorder associated with isoniazid.",
"role": "user"
},
{
"content": "[{'ade': 'Psychotic disorder', 'drug': 'isoniazid'}]",
"role": "assistant"
}
] |
However, a recent post-marketing survey in Japan revealed that interstitial pneumonia occurred in 4 among approximately 2 000 Japanese patients treated with sorafenib.
|
[
{
"ade": "interstitial pneumonia",
"drug": "sorafenib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, a recent post-marketing survey in Japan revealed that interstitial pneumonia occurred in 4 among approximately 2 000 Japanese patients treated with sorafenib.",
"role": "user"
},
{
"content": "[{'ade': 'interstitial pneumonia', 'drug': 'sorafenib'}]",
"role": "assistant"
}
] |
Toxicity related to chloroquine treatment of resistant vivax malaria.
|
[
{
"ade": "Toxicity",
"drug": "chloroquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Toxicity related to chloroquine treatment of resistant vivax malaria.",
"role": "user"
},
{
"content": "[{'ade': 'Toxicity', 'drug': 'chloroquine'}]",
"role": "assistant"
}
] |
A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.
|
[
{
"ade": "acute renal failure",
"drug": "MTX"
},
{
"ade": "acute renal failure",
"drug": "methotrexate"
},
{
"ade": "elevation of aspartate aminotrasferase",
"drug": "methotrexate"
},
{
"ade": "elevation of aspartate aminotrasferase",
"drug": "MTX"
},
{
"ade": "renal toxicity",
"drug": "methotrexate"
},
{
"ade": "renal toxicity",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.",
"role": "user"
},
{
"content": "[{'ade': 'acute renal failure', 'drug': 'MTX'}, {'ade': 'acute renal failure', 'drug': 'methotrexate'}, {'ade': 'elevation of aspartate aminotrasferase', 'drug': 'methotrexate'}, {'ade': 'elevation of aspartate aminotrasferase', 'drug': 'MTX'}, {'ade': 'renal toxicity', 'drug': 'methotrexate'}, {'ade': 'renal toxicity', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
OBJECTIVE: To describe a case of cefazolin-induced leukopenia in a critically ill patient who developed this adverse reaction upon rechallenge with cefoxitin.
|
[
{
"ade": "leukopenia",
"drug": "cefazolin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To describe a case of cefazolin-induced leukopenia in a critically ill patient who developed this adverse reaction upon rechallenge with cefoxitin.",
"role": "user"
},
{
"content": "[{'ade': 'leukopenia', 'drug': 'cefazolin'}]",
"role": "assistant"
}
] |
Delayed hypersensitivity to flurbiprofen.
|
[
{
"ade": "Delayed hypersensitivity",
"drug": "flurbiprofen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Delayed hypersensitivity to flurbiprofen.",
"role": "user"
},
{
"content": "[{'ade': 'Delayed hypersensitivity', 'drug': 'flurbiprofen'}]",
"role": "assistant"
}
] |
However, recurrent staphylococcus aureus sepsis developed during CyA therapy.
|
[
{
"ade": "staphylococcus aureus sepsis",
"drug": "CyA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, recurrent staphylococcus aureus sepsis developed during CyA therapy.",
"role": "user"
},
{
"content": "[{'ade': 'staphylococcus aureus sepsis', 'drug': 'CyA'}]",
"role": "assistant"
}
] |
The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.
|
[
{
"ade": "proarrhythmic",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.",
"role": "user"
},
{
"content": "[{'ade': 'proarrhythmic', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.
|
[
{
"ade": "DRESS",
"drug": "zonisamide"
},
{
"ade": "DIHS",
"drug": "zonisamide"
},
{
"ade": "acute kidney injury",
"drug": "zonisamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.",
"role": "user"
},
{
"content": "[{'ade': 'DRESS', 'drug': 'zonisamide'}, {'ade': 'DIHS', 'drug': 'zonisamide'}, {'ade': 'acute kidney injury', 'drug': 'zonisamide'}]",
"role": "assistant"
}
] |
Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.
|
[
{
"ade": "infectious mononucleosis-like syndrome",
"drug": "salazosulfapyridine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.",
"role": "user"
},
{
"content": "[{'ade': 'infectious mononucleosis-like syndrome', 'drug': 'salazosulfapyridine'}]",
"role": "assistant"
}
] |
Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.
|
[
{
"ade": "TTP",
"drug": "penicillamine"
},
{
"ade": "Thrombotic thrombocytopenic purpura",
"drug": "penicillamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.",
"role": "user"
},
{
"content": "[{'ade': 'TTP', 'drug': 'penicillamine'}, {'ade': 'Thrombotic thrombocytopenic purpura', 'drug': 'penicillamine'}]",
"role": "assistant"
}
] |
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