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12,552,966 | A phase II study of weekly methotrexate, cisplatin, and 24-hour infusion of high-dose 5-fluorouracil and leucovorin (MP-HDFL) in patients with metastatic and recurrent esophageal cancer-improving toxicity profile by infusional schedule and double biochemical modulation of 5-fluorouracil. | Anticancer research | Anticancer Res | 22 | 6B | null | eng | 2,002 | null | null | null | null | null | [BACKGROUND] Patients with advanced esophageal cancer are frequently not indicated for intensive chemotherapy due to aero-digestive tract complications. In order to improve the therapeutic index of systemic chemotherapy for these patients, we designed a weekly MP-HDFL protocol, which took advantage of the low toxicity ... | null | null | null | null | null | null |
12,551,869 | Alcohol consumption and plasma concentration of C-reactive protein. | Circulation | Circulation | 107 | 3 | 10.1161/01.cir.0000045669.16499.ec | eng | 2,003 | 1 | 28 | null | null | null | [BACKGROUND] Moderate alcohol intake has been associated with lower cardiovascular mortality. However, data evaluating the relationship between C-reactive protein (CRP), a predictor of cardiovascular risk, and alcohol consumption are sparse. [METHODS AND RESULTS] The relationship between alcohol consumption and CRP was... | null | 5.768 | 691 | Cardiology and Cardiovascular Medicine; Physiology | Medicine | 2,003 |
12,551,785 | Mid-trimester amniotic fluid angiogenin, lactate dehydrogenase and fibronectin in the prediction of preterm delivery. | European journal of obstetrics, gynecology, and reproductive biology | Eur J Obstet Gynecol Reprod Biol | 106 | 2 | 10.1016/s0301-2115(02)00264-6 | eng | 2,003 | 2 | 10 | null | null | null | [OBJECTIVE] Our purpose was to compare angiogenin, lactate dehydrogenase (LDH) and fibronectin levels in mid-trimester amniotic fluid of patients with preterm and term deliveries and to find out their predictive values for preterm birth. [STUDY DESIGN] A prospective cohort study was conducted in 55 pregnancies with sin... | null | null | null | null | null | null |
12,549,943 | Aminoglycoside-associated nephrotoxicity in the elderly. | The Annals of pharmacotherapy | Ann Pharmacother | 37 | 2 | 10.1177/106002800303700203 | eng | 2,003 | 2 | null | null | null | null | [OBJECTIVE] To determine whether there was an increased incidence of nephrotoxicity in elderly patients (> or =65 y) prescribed single-dose (SD) versus multiple-dose (MD) aminoglycosides and whether aminoglycoside-induced nephrotoxicity was associated with length of therapy and other risk factors. [METHODS] A prospecti... | null | 0.632 | 125 | Medicine; Pharmacology | Medicine | 2,003 |
12,548,596 | Radiofrequency ablation of adrenal tumors and adrenocortical carcinoma metastases. | Cancer | Cancer | 97 | 3 | 10.1002/cncr.11084 | eng | 2,003 | 2 | 1 | null | null | null | [BACKGROUND] The current study was performed to analyze the feasibility, safety, imaging appearance, and short-term efficacy of image-guided percutaneous radiofrequency ablation (RFA) of primary and metastatic adrenal neoplasms including adrenocortical carcinoma. [METHODS] The procedure was performed using 36 treatment... | null | 1.864 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,003 |
12,548,270 | Utility of the peripheral blood white blood cell count for identifying sick young infants who need lumbar puncture. | Annals of emergency medicine | Ann Emerg Med | 41 | 2 | 10.1067/mem.2003.9 | eng | 2,003 | 2 | null | null | null | null | [STUDY OBJECTIVE] We assess the utility of the peripheral blood WBC count as a screen for lumbar puncture among young infants evaluated for serious bacterial infections. [METHODS] We performed logistic regression modeling and receiver operating characteristic curve analysis of peripheral blood WBC count and cerebrospin... | null | 1.212 | 178 | Emergency Medicine | Medicine | 2,003 |
12,548,127 | Origin and subset distribution of peripheral blood dendritic cells in patients with chronic graft-versus-host disease. | Transplantation | Transplantation | 75 | 2 | 10.1097/01.TP.0000041783.34083.11 | eng | 2,003 | 1 | 27 | null | null | null | [BACKGROUND] After allogeneic hematopoietic stem cell transplantation, donor T cells interact with an antigen-presenting cell environment that is distorted in number, level of activation, and origin. The role of antigen presentation in the development of chronic graft-versus host disease (cGVHD) is unknown. [METHODS] T... | null | 1.519 | 224 | Transplantation | Medicine | 2,003 |
12,547,661 | Adolescents' attitudes and experiences regarding levonorgestrel 100 mcg/ethinyl estradiol 20 mcg. | Journal of pediatric and adolescent gynecology | J Pediatr Adolesc Gynecol | 15 | 5 | 10.1016/s1083-3188(02)00196-1 | eng | 2,002 | 12 | null | null | null | null | [STUDY OBJECTIVE] Oral contraceptive pills (OCs) are a commonly prescribed method of birth control for sexually experienced adolescents. The purpose of the current study was to describe anticipated parental involvement and adolescent compliance with pill taking, and to describe experiences with a 20-mcg OC regarding sa... | null | 0.316 | 73 | Medicine; Obstetrics and Gynecology; Pediatrics, Perinatology and Child Health | Medicine | 2,002 |
12,547,369 | Concept and development of an orthotropic FE model of the proximal femur. | Journal of biomechanics | J Biomech | 36 | 2 | 10.1016/s0021-9290(02)00309-3 | eng | 2,003 | 2 | null | null | null | null | [PURPOSE] In contrast to many isotropic finite-element (FE) models of the femur in literature, it was the object of our study to develop an orthotropic FE "model femur" to realistically simulate three-dimensional bone remodelling. [METHODS] The three-dimensional geometry of the proximal femur was reconstructed by CT sc... | null | 1.313 | 233 | Biomedical Engineering; Biophysics; Orthopedics and Sports Medicine; Rehabilitation; Sports Science | Biochemistry, Genetics and Molecular Biology; Engineering; Health Professions; Medicine | 2,003 |
12,546,781 | Genetic affinities of the Andaman Islanders, a vanishing human population. | Current biology : CB | Curr Biol | 13 | 2 | 10.1016/s0960-9822(02)01336-2 | eng | 2,003 | 1 | 21 | null | null | null | [BACKGROUND] The Andaman Islands in the Bay of Bengal are inhabited by hunter-gatherers of unknown origin, now on the verge of extinction. The Andamanese and other Asian small-statured peoples, traditionally known as "Negritos," resemble African pygmies. However, it is generally believed that they descend from the earl... | null | null | null | null | null | null |
12,546,297 | Effect of dietary sodium on fluid/electrolyte regulation during bed rest. | Aviation, space, and environmental medicine | Aviat Space Environ Med | 74 | 1 | null | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] A negative fluid balance during bed rest (BR) is accompanied by decreased plasma volume (PV) which contributes to cardiovascular deconditioning. [HYPOTHESIS] We hypothesized that increasing dietary sodium while controlling fluid intake would increase plasma osmolality (POSM), stimulate fluid conserving hor... | NASA Center JSC; NASA Discipline Regulatory Physiology | null | null | null | null | null |
12,545,684 | Activated satellite cells are present in uninjured extraocular muscles of mature mice. | Transactions of the American Ophthalmological Society | Trans Am Ophthalmol Soc | 100 | null | null | eng | 2,002 | null | null | null | null | null | [PURPOSE] We recently demonstrated that there is a continuous process of myonuclear addition into normal, uninjured adult myofibers in rabbit extraocular muscles (EOM). This phenomenon is not seen in skeletal muscles from normal, adult limbs. These features may explain the selective involvement of the EOM in progressiv... | null | null | null | null | null | null |
12,544,946 | A histologic and functional study on cauda equina adhesion induced by multiple level laminectomy. | Spine | Spine (Phila Pa 1976) | 28 | 1 | 10.1097/00007632-200301010-00003 | eng | 2,003 | 1 | 1 | null | null | null | [STUDY DESIGN] A histologic and functional study on cauda equina adhesion induced by multiple-level laminectomy was performed using rats. [OBJECTIVE] To assess the relation between the extent of laminectomy and histologic and functional changes of the cauda equina induced by laminectomy. [SUMMARY OF BACKGROUND DATA] It... | null | 1.22 | 300 | Neurology; Orthopedics and Sports Medicine; Sports Science | Health Professions; Medicine | 2,003 |
12,544,350 | Successful diagnosis of orthotopic rat superficial bladder tumor model by ultrathin cystoscopy. | The Journal of urology | J Urol | 169 | 2 | 10.1097/01.ju.0000038092.63280.a0 | eng | 2,003 | 2 | null | null | null | null | [PURPOSE] In the orthotopic animal bladder tumor model noninvasive evaluation of the tumor establishment and the therapeutic effect has been difficult. To our knowledge we present the first diagnosis of orthotopic rat superficial bladder tumor model by ultrathin cystoscopy. [MATERIALS AND METHODS] The established AY-27... | null | 1.702 | 291 | Urology | Medicine | 2,003 |
12,544,162 | Medication use in athletes selected for doping control at the Sydney Olympics (2000). | Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine | Clin J Sport Med | 13 | 1 | 10.1097/00042752-200301000-00007 | eng | 2,003 | 1 | null | null | null | null | [UNLABELLED] During the Olympic Games held in Sydney in September, 2000 Doping Control was undertaken as specified in the International Olympic Code. During this process information about the medications taken by athletes was collected as a routine and formed part of the paperwork associated with a urine test. In their... | null | 0.693 | 121 | Orthopedics and Sports Medicine; Physical Therapy, Sports Therapy and Rehabilitation; Sports Science | Health Professions; Medicine | 2,003 |
12,544,013 | Inhibition of alcohol-associated colonic hyperregeneration by alpha-tocopherol in the rat. | Alcoholism, clinical and experimental research | Alcohol Clin Exp Res | 27 | 1 | 10.1097/01.ALC.0000046341.31828.A4 | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] Chronic alcohol consumption results in colorectal mucosal hyperregeneration, a condition associated with an increased risk for colorectal cancer. Possible mechanisms may involve the effects of acetaldehyde and/or free radicals generated during alcohol metabolism. Vitamin E is part of the antioxidative defe... | null | null | null | null | null | null |
12,543,895 | Prospective evaluation of failure modes in autogenous radiocephalic wrist access for haemodialysis. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | Nephrol Dial Transplant | 18 | 2 | 10.1093/ndt/18.2.378 | eng | 2,003 | 2 | null | null | null | null | [INTRODUCTION] Radiocephalic wrist arteriovenous fistulae (RCAVF) are the primary and best option for vascular access for haemodialysis treatment. However, 10-24% of these AVFs fail due directly to thrombosis and non-maturation. In a prospective study, the failure modes of radiocephalic AVFs and the impact of surgical ... | null | 0.896 | 203 | Medicine; Nephrology; Transplantation | Medicine | 2,003 |
12,543,567 | Visceral artery aneurysms: a single center experience. | Cardiovascular surgery (London, England) | Cardiovasc Surg | 11 | 1 | 10.1016/s0967-2109(02)00121-7 | eng | 2,003 | 2 | null | null | null | null | [BACKGROUND] Splanchnic artery areurysm is a rare but clinically relevant disease, showing a high mortality rate in emergency surgery. Reports on splanchnic aneurysms are rare and often anecdotal. The aim of this study is to discuss data obtained from 16 patients in a single vascular surgery center. [MATERIALS AND METH... | null | null | null | null | null | null |
12,542,963 | Animal study on expression of laminin and fibronectin in cornea during wound healing following alkali burn. | Chinese journal of traumatology = Zhonghua chuang shang za zhi | Chin J Traumatol | 6 | 1 | null | eng | 2,003 | 2 | null | null | null | null | [OBJECTIVE] To observe the expression of laminin and fibronectin in alkali-burned corneas in rats. [METHODS] A total of 18 normal Wistar rats were randomly divided into 6 groups (n = 3 in each group). For each rat, one eye was injured by alkali burn, the other one was taken as the normal control. Then all the corneas w... | null | null | null | null | null | null |
12,542,831 | Proliferation and distribution of myoepithelial cells during atrophy of the rat sublingual gland. | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology | J Oral Pathol Med | 32 | 2 | 10.1034/j.1600-0714.2003.00043.x | eng | 2,003 | 2 | null | null | null | null | [BACKGROUND] The present study was aimed to determine the proliferation and distribution of myoepithelial cells during atrophy of rat sublingual glands. [METHODS] The excretory duct of the right sublingual gland of rats was doubly ligated with metal clips to induce atrophy in the gland. The atrophic sublingual glands w... | null | null | null | null | null | null |
12,542,582 | Mass media release of medical research results: an analysis of antihypertensive drug prescribing in the aftermath of the calcium channel blocker scare of March 1995. | Journal of general internal medicine | J Gen Intern Med | 18 | 2 | 10.1046/j.1525-1497.2003.20502.x | eng | 2,003 | 2 | null | null | null | null | [BACKGROUND] Disclosure of medical research results to the public creates tension between lay medical reporters and the medical profession. [OBJECTIVE] To explore the early effect of media attention on the risks associated with short-acting calcium channel blockers (CCBs) for treating hypertension after publication at ... | null | 1.81 | 224 | Internal Medicine | Medicine | 2,003 |
12,541,046 | Development of a bent-type tube stent for simultaneous drainage of bile and pancreatic juice. | Journal of hepato-biliary-pancreatic surgery | J Hepatobiliary Pancreat Surg | 9 | 5 | 10.1007/s005340200080 | eng | 2,002 | null | null | null | null | null | [BACKGROUND/PURPOSE] Endoscopic lithotomy is a useful medical procedure for treating choledocholithiasis. Although this procedure is commonly performed, complications such as pancreatitis and cholangitis are recognized as major and serious problems. The obstruction of bile and pancreatic juice flow caused by papillary ... | null | null | null | null | null | null |
12,541,021 | Changes in gastrointestinal motility after subtotal colectomy in dogs. | Surgery today | Surg Today | 32 | 12 | 10.1007/s005950200212 | eng | 2,002 | null | null | null | null | null | [PURPOSE] This study was conducted to examine recovery from diarrhea after subtotal colectomy by observing changes in gastrointestinal motility, neuropeptides, and autonomic nerves in the enteric nervous system in dogs. [METHODS] The moisture volume of intestinal matter recovered from the ileal side of the anastomosis ... | null | 0.329 | 77 | Medicine; Surgery | Medicine | 2,002 |
12,540,727 | Psychosocial risk factors for heart disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). | International journal of epidemiology | Int J Epidemiol | 31 | 6 | 10.1093/ije/31.6.1227 | eng | 2,002 | 12 | null | null | null | null | [BACKGROUND] France has a substantially lower level of premature mortality from cardiovascular diseases (CVD) relative to its comparators. Compared with Northern Ireland, France has one-half the rate, despite having a similar cardiovascular risk profile to Northern Ireland. In this prospective longitudinal study the ps... | null | 1.064 | 256 | Medicine; Epidemiology | Medicine | 2,002 |
12,540,352 | Proximal femur fracture in older patients--rehabilitation and clinical outcome. | Age and ageing | Age Ageing | 32 | 1 | 10.1093/ageing/32.1.74 | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] hip fracture is a major cause of morbidity and mortality in older people; optimal post-surgical treatment is a matter of controversy. [OBJECTIVE] to examine the effects of rehabilitation on the clinical outcome following surgical treatment of hip fracture. [DESIGN] prospective longitudinal study in three g... | null | 0.668 | 175 | Geriatrics and Gerontology; Medicine; Aging | Biochemistry, Genetics and Molecular Biology; Medicine | 2,003 |
12,540,023 | Expression of proteinase-activated receptor 2 during taurocholate-induced acute pancreatic lesion development in Wistar rats. | International journal of gastrointestinal cancer | Int J Gastrointest Cancer | 30 | 3 | 10.1385/IJGC:30:3:113 | eng | 2,001 | null | null | null | null | null | [BACKGROUND] Proteinase-activated receptor 2 (PAR-2) is a G-protein coupled transmembrane receptor activated by trypsin by site-specific cleavage. Its presence on pancreatic structures was demonstrated in the past. PAR-2 physiologically involves in duct/acinary cells secretion, arterial tonus regulation or capillary li... | null | null | null | null | null | null |
12,539,992 | Health care priorities for menopausal women with a history of breast cancer. | Southern medical journal | South Med J | 95 | 11 | null | eng | 2,002 | 11 | null | null | null | null | [BACKGROUND] The opinion of breast cancer survivors and their physicians about long-term health, especially menopause, is not well understood. [METHODS] Seventy-three patients and 22 physicians answered questions regarding medical follow-up and menopause. [RESULTS] One third of specialists preferred follow-up of 5 year... | null | null | null | null | null | null |
12,539,154 | Efficacy of interleukin-10 gene electrotransfer into skeletal muscle in mice with collagen-induced arthritis. | The journal of gene medicine | J Gene Med | 5 | 2 | 10.1002/jgm.321 | eng | 2,003 | 2 | null | null | null | null | [BACKGROUND] Gene therapy is very promising in the treatment of rheumatoid arthritis (RA). Electrotransfer is a recent method reported to enhance in vivo intramuscular DNA transfection. Interleukin-10 (IL-10) has antiinflammatory effects in RA and in collagen-induced arthritis (CIA), a murine model of RA. In order to i... | null | 1.238 | 102 | Drug Discovery; Genetics; Genetics; Molecular Biology; Molecular Medicine | Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,003 |
12,538,472 | Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. | Clinical cancer research : an official journal of the American Association for Cancer Research | Clin Cancer Res | 9 | 1 | null | eng | 2,003 | 1 | null | null | null | null | [PURPOSE] Focal adhesion kinase (FAK), a protein tyrosine kinase that functions in signaling events between cells and their extracellular matrix, is overexpressed in a variety of human solid tumors. To determine whether FAK expression is up-regulated in colorectal cancer, we analyzed FAK mRNA and protein levels in prim... | null | 2.821 | 392 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,003 |
12,538,437 | Increased medial degradation with pseudo-aneurysm formation in apolipoprotein E-knockout mice deficient in tissue inhibitor of metalloproteinases-1. | Circulation | Circulation | 107 | 2 | 10.1161/01.cir.0000044915.37074.5c | eng | 2,003 | 1 | 21 | null | null | null | [BACKGROUND] The tissue inhibitor of metalloproteinases-1 (TIMP-1) is expressed in atherosclerotic lesions, where it may play a critical role in regulating the activity of matrix metalloproteinases (MMPs). Several MMPs are overexpressed in the atherosclerotic plaque, and they are believed to contribute to the expansion... | null | 5.768 | 691 | Cardiology and Cardiovascular Medicine; Physiology | Medicine | 2,003 |
12,535,127 | Identification of Thiothrix unzii in two distinct ecosystems. | Letters in applied microbiology | Lett Appl Microbiol | 36 | 2 | 10.1046/j.1472-765x.2003.01256.x | eng | 2,003 | null | null | null | null | null | [AIMS] Molecular procedures were used to identify Thiothrix spp. in biofilms from sulphide-rich waters in two distinct ecosystems. [METHODS AND RESULTS] Biofilm samples were obtained from two groundwater-fed systems in central and northern Florida, including an artesian spring and municipal water tank. The 16S rDNA in ... | null | 0.709 | 133 | Applied Microbiology and Biotechnology | Immunology and Microbiology | 2,003 |
12,534,824 | Raw potato starch and short-chain fructo-oligosaccharides affect the composition and metabolic activity of rat intestinal microbiota differently depending on the caecocolonic segment involved. | Journal of applied microbiology | J Appl Microbiol | 94 | 2 | 10.1046/j.1365-2672.2003.01836.x | eng | 2,003 | null | null | null | null | null | [AIMS] In vitro studies have suggested that fructo-oligosaccharides (FOS) and resistant starch (two fermentable non-digestible carbohydrates) display different fermentation kinetics. This study investigated whether these substrates affect the metabolic activity and bacterial composition of the intestinal microflora dif... | null | 0.956 | 195 | Applied Microbiology and Biotechnology; Biotechnology; Medicine | Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine | 2,003 |
12,534,548 | Skin test with a timothy grass (Phleum pratense) pollen extract vs. IgE to a timothy extract vs. IgE to rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6, rPhl p 7, rPhl p 11, and rPhl p 12: epidemiological and diagnostic data. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology | Clin Exp Allergy | 33 | 1 | 10.1046/j.1365-2222.2003.01569.x | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] The diagnostic approach to grass pollen allergy is now possible by detecting specific IgE to its allergenic components. [OBJECTIVE] To compare the IgE reactivity to a timothy grass pollen extract with the IgE reactivity to eight allergenic components from the same source (Phl p 1, 2, 4, 5, 6, 7, 11, 12). B... | null | 1.327 | 176 | Immunology; Immunology and Allergy | Immunology and Microbiology; Medicine | 2,003 |
12,534,452 | Impact of diabetes duration and cardiovascular risk factors on mortality in type 2 diabetes: the Hoorn Study. | European journal of clinical investigation | Eur J Clin Invest | 32 | 12 | 10.1046/j.1365-2362.2002.01090.x | eng | 2,002 | 12 | null | null | null | null | [BACKGROUND] Several studies have reported differences in the mortality risk between diabetic subjects detected by screening and known diabetic patients. We studied mortality in relation to diabetes duration, and the contribution of other cardiovascular risk factors to the elevated risk. [MATERIALS AND METHODS] Partici... | null | 0.907 | 126 | Clinical Biochemistry; Medicine; Biochemistry | Biochemistry, Genetics and Molecular Biology; Medicine | 2,002 |
12,534,411 | Effect of different proton pump inhibitors, differences in CYP2C19 genotype and antibiotic resistance on the eradication rate of Helicobacter pylori infection by a 1-week regimen of proton pump inhibitor, amoxicillin and clarithromycin. | Alimentary pharmacology & therapeutics | Aliment Pharmacol Ther | 17 | 2 | 10.1046/j.1365-2036.2003.01406.x | eng | 2,003 | 1 | null | null | null | null | [AIM] To investigate the effect of different proton pump inhibitors, S-mephenytoin 4'-hydroxylase (CYP2C19) genotype and antibiotic susceptibility on the eradication rate of Helicobacter pylori. [METHODS] One hundred and eighty-seven H. pylori-infected peptic ulcer patients were randomly treated with either rabeprazole... | null | null | null | null | null | null |
12,534,404 | Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib. | Alimentary pharmacology & therapeutics | Aliment Pharmacol Ther | 17 | 2 | 10.1046/j.1365-2036.2003.01407.x | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] Cyclo-oxygenase-2-selective non-steroidal anti-inflammatory drugs are intended to preserve cyclo-oxygenase-1-mediated gastroprotection and platelet function, whilst inhibiting cyclo-oxygenase-2-mediated inflammation. [AIM] To assess the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor e... | null | null | null | null | null | null |
12,532,466 | The effect of famotidine on gastroesophageal and duodeno-gastro-esophageal refluxes in critically ill patients. | World journal of gastroenterology | World J Gastroenterol | 9 | 2 | 10.3748/wjg.v9.i2.356 | eng | 2,003 | 2 | null | null | null | null | [AIM] To investigate the effect of famotidine on gastroesophageal reflux (GER) and duodeno-gastro-esophageal reflux (DGER) and to explore it's possible mechanisms. To identify the relevant factors of the reflux. [METHODS] Nineteen critically ill patients were consecutively enrolled in the study. Dynamic 24 hours monito... | null | null | null | null | null | null |
12,532,457 | Inhibition on the production of collagen type I, III of activated hepatic stellate cells by antisense TIMP-1 recombinant plasmid. | World journal of gastroenterology | World J Gastroenterol | 9 | 2 | 10.3748/wjg.v9.i2.316 | eng | 2,003 | 2 | null | null | null | null | [AIM] To investigate the inhibition effects on the production of collagen type I, III secreted by activated rat hepatic stellate cells (rHSCs) by antisense tissue inhibitors of metalloproteinase 1 (TIMP-1) recombinant plasmid through elevating interstitial collagenase activity. [METHODS] rHSCs were extracted from norma... | null | null | null | null | null | null |
12,532,242 | Stress during ACLS courses: is it important for learning skills? | Arquivos brasileiros de cardiologia | Arq Bras Cardiol | 79 | 6 | 10.1590/s0066-782x2002001500004 | eng | 2,002 | 12 | null | null | null | null | [OBJECTIVE] To determine the influence of stress on teaching medical emergencies in an Advanced Cardiac Life Support (ACLS) course and to verify this influence on learning, and the efficiency of emergency care training. [METHODS] Seventeen physicians signed up for an ACLS course. Their pulses were taken and blood press... | null | 0.126 | 66 | Cardiology and Cardiovascular Medicine | Medicine | 2,002 |
12,532,102 | Is there an association between inhaled corticosteroids and bone density in postmenopausal women? | The Journal of allergy and clinical immunology | J Allergy Clin Immunol | 111 | 1 | 10.1067/mai.2003.4 | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] During the last decades, there has been increased concern about the association between oral corticosteroid (OC) therapy and osteoporosis. [OBJECTIVE] The question currently discussed is whether inhaled corticosteroids (ICs) in recommended doses have any clinically relevant effects on bone mineral density ... | null | 2.678 | 350 | Immunology; Immunology and Allergy | Immunology and Microbiology; Medicine | 2,003 |
12,531,960 | Visual prognosis after indirect traumatic optic neuropathy. | Journal of neurology, neurosurgery, and psychiatry | J Neurol Neurosurg Psychiatry | 74 | 2 | 10.1136/jnnp.74.2.246 | eng | 2,003 | 2 | null | null | null | null | [OBJECTIVE] To investigate a possible correlation between final visual acuity and the presence at baseline of various systemic and local (orbital/ocular) signs in patients affected by indirect traumatic optic neuropathy. [METHODS] 35 cases of traumatic optic neuropathy were examined retrospectively and 13 variables wer... | null | 1.36 | 244 | Neurology; Psychiatry and Mental Health; Surgery | Medicine | 2,003 |
12,531,446 | Rectal cancer surgery in patients more than 80 years of age. | American journal of surgery | Am J Surg | 185 | 1 | 10.1016/s0002-9610(02)01120-0 | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] This retrospective study aimed to compare the prognosis for rectal cancer in patients more than 80 years old with that observed in younger patients. [METHODS] Patients operated on for a rectal adenocarcinoma, from 1980 to 1998, were divided into two groups: group 1 (>80 years, n = 92); group 2 (<80 years, ... | null | 1.174 | 173 | Medicine; Surgery | Medicine | 2,003 |
12,530,045 | Tolerability of Raltitrexed ('Tomudex') in elderly patients with colorectal cancer. | Anticancer research | Anticancer Res | 22 | 5 | null | eng | 2,002 | null | null | null | null | null | [PURPOSE] Colorectal cancer (CRC) is one of the major health problems of the Western world and the proportion of elderly patients with CRC is growing. Raltitrexed ('Tomudex'), a specific thymidylate synthase inhibitor, has shown efficacy and manageable toxicity in elderly CRC patients. In this retrospective study, the ... | null | null | null | null | null | null |
12,530,014 | Immunohistochemical detection of C-kit (CD117) and vascular endothelial growth factor (VEGF) overexpression in mantle cell lymphoma. | Anticancer research | Anticancer Res | 22 | 5 | null | eng | 2,002 | null | null | null | null | null | [BACKGROUND] Mantle cell lymphoma (MCL) is a low-grade lymphoproliferative malignancy that is extremely refractory to chemotherapy. Commonly used treatments have yielded unfavorable response rates (30% complete remission). We evaluated the incidence of c-kit (CD117) and vascular endothelial growth factor (VEGF) overexp... | null | null | null | null | null | null |
12,529,985 | Evidence for a direct antitumor mechanism of action of bovine lactoferricin. | Anticancer research | Anticancer Res | 22 | 5 | null | eng | 2,002 | null | null | null | null | null | [BACKGROUND] Bovine lactoferrin (LFB) and its pepsin-generated peptide lactoferricin (LfcinB) possess antitumor activities. The mechanism underlying the antitumor activities of LfcinB in vivo has not been elucidated. In this study the antitumor activities exerted by LFB, LfcinB and murine lactoferricin (LfcinM) on muri... | null | null | null | null | null | null |
12,529,091 | Pravastatin for secondary prevention of cardiovascular events in persons with mild chronic renal insufficiency. | Annals of internal medicine | Ann Intern Med | 138 | 2 | 10.7326/0003-4819-138-2-200301210-00010 | eng | 2,003 | 1 | 21 | null | null | null | [BACKGROUND] Cardiovascular disease is a common cause of morbidity and death in persons with renal insufficiency. Although 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors (statins) are effective for secondary prevention of cardiovascular events in the general population, they have not been specifically studie... | null | 4.143 | 445 | Internal Medicine; Medicine | Medicine | 2,003 |
12,528,966 | Are preventive drugs preventive enough? A study of patients' expectation of benefit from preventive drugs. | Clinical medicine (London, England) | Clin Med (Lond) | 2 | 6 | 10.7861/clinmedicine.2-6-527 | eng | 2,002 | null | null | null | null | null | [OBJECTIVES] The study aimed to find the threshold of benefit for a hypothetical cholesterol-lowering drug below which the subject would not be prepared to take the drug. We also looked at whether proximity to the target event (myocardial infarction) and the subjects' views on drug taking affected this threshold. [DESI... | null | null | null | null | null | null |
12,527,665 | Comprehensive cardiac rehabilitation programme for implantable cardioverter-defibrillator patients: a randomised controlled trial. | Heart (British Cardiac Society) | Heart | 89 | 2 | 10.1136/heart.89.2.155 | eng | 2,003 | 2 | null | null | null | null | [OBJECTIVE] To investigate the effects of a 12 week comprehensive cardiac rehabilitation (CCR) programme on patients who have undergone implantation of an implantable cardioverter-defibrillator (ICD). [DESIGN] Sixteen patients with ICDs (14 (88%) male, mean (SD) age 58 (10) years, range 34-74 years) were randomised to ... | null | 0.825 | 214 | Cardiology and Cardiovascular Medicine | Medicine | 2,003 |
12,527,602 | High-altitude pulmonary edema at moderate altitude (< 2,400 m; 7,870 feet): a series of 52 patients. | Chest | Chest | 123 | 1 | 10.1378/chest.123.1.49 | eng | 2,003 | 1 | null | null | null | null | [STUDY OBJECTIVES] To describe a group of patients who acquired pulmonary edema at a moderate altitude of 1,400 to 2,400 m. [DESIGN] Observational, retrospective chart review (1992-2000) of a series of 52 consecutive patients admitted for high-altitude pulmonary edema (HAPE) that occurred at 1,400 to 2,400 m. [SETTING]... | null | 1.463 | 337 | Cardiology and Cardiovascular Medicine; Critical Care and Intensive Care Medicine; Pulmonary and Respiratory Medicine | Medicine | 2,003 |
12,525,458 | Expression of erythropoietin and erythropoietin receptor in peritoneal endometriosis. | Human reproduction (Oxford, England) | Hum Reprod | 18 | 1 | 10.1093/humrep/deg007 | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] Recent studies have indicated new physiological roles for erythropoietin (Epo) unrelated to erythropoiesis. We previously demonstrated that the Epo concentrations in peritoneal fluid from patients with stage I endometriosis were significantly higher than those with stages II, III and IV of the disease. The... | null | 1.688 | 264 | Obstetrics and Gynecology; Rehabilitation; Reproductive Medicine | Medicine | 2,003 |
12,525,200 | Elective management of the clinically negative neck by otolaryngologists in patients with oral tongue cancer. | Archives of otolaryngology--head & neck surgery | Arch Otolaryngol Head Neck Surg | 129 | 1 | 10.1001/archotol.129.1.83 | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] The treatment of patients with squamous cell carcinoma of the head and neck who have a clinically negative (cN0) neck remains controversial. Furthermore, the treatment delivered to patients with a cN0 neck by practicing otolaryngologists is not known. [OBJECTIVE] To determine the variability in the managem... | null | null | null | null | null | null |
12,524,616 | Crosslinking of fibrinogen and fibronectin by free radicals: a possible initial step in adhesion formation in osteoarthritis of the temporomandibular joint. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | J Oral Maxillofac Surg | 61 | 1 | 10.1053/joms.2003.50047 | eng | 2,003 | 1 | null | null | null | null | [PURPOSE] Adhesion formation in osteoarthritis (OA) of the temporomandibular joint (TMJ) typically results in a sustained limitation of joint movement. We propose the hypothesis that free-radical-mediated crosslinking of proteins underlies this adhesion formation in affected joints. Free radicals may cause oxidative mo... | null | 0.549 | 147 | Otorhinolaryngology; Surgery; Oral Surgery | Dentistry; Medicine | 2,003 |
12,524,606 | Simple disc reshaping surgery for internal derangement of the temporomandibular joint: 5-year follow-up results. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | J Oral Maxillofac Surg | 61 | 1 | 10.1053/joms.2003.50007 | eng | 2,003 | 1 | null | null | null | null | [PURPOSE] The goal of this study was to evaluate the clinical results of simple disc reshaping (SDR) surgery alone for treating dysfunctional internal derangement of the temporomandibular joint. [PATIENTS AND METHODS] Eleven patients with symptomatic unilateral anterior disc displacement with disc deformation were trea... | null | 0.549 | 147 | Otorhinolaryngology; Surgery; Oral Surgery | Dentistry; Medicine | 2,003 |
12,524,238 | The serpin protease-nexin 1 is present in rat aortic smooth muscle cells and is upregulated in L-NAME hypertensive rats. | Arteriosclerosis, thrombosis, and vascular biology | Arterioscler Thromb Vasc Biol | 23 | 1 | 10.1161/01.atv.0000047867.98019.2d | eng | 2,003 | 1 | 1 | null | null | null | [OBJECTIVE] Protease-nexin 1 (PN-1) belongs to the serpin superfamily and behaves as a specific thrombin inhibitor in the pericellular environment. Little is known about PN-1 expression and its regulation in the vascular system. In this study, we examined the expression of functionally active PN-1 in vitro in rat aorti... | null | 3.551 | 301 | Cardiology and Cardiovascular Medicine | Medicine | 2,003 |
12,523,661 | Multivariate statistics of disposition pharmacokinetic parameters for structurally unrelated drugs used in therapeutics. | Pharmaceutical research | Pharm Res | 19 | 12 | 10.1023/a:1021489323828 | eng | 2,002 | 12 | null | null | null | null | [PURPOSE] To explore the quantitative structure pharmacokinetic relationships of the disposition parameters: clearance (CL), apparent volume of drug distribution (V(ap)), fractal clearance (CL(f)), and fractal volume (v(f)) for 272 structurally unrelated drugs used in therapeutics. [METHODS] Literature data were used f... | null | 1.012 | 235 | Biotechnology; Organic Chemistry; Pharmaceutical Science; Pharmacology; Pharmacology; Molecular Medicine | Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,002 |
12,522,833 | Measuring exercise-induced mood changes in fibromyalgia: a comparison of several measures. | Arthritis and rheumatism | Arthritis Rheum | 47 | 6 | 10.1002/art.10789 | eng | 2,002 | 12 | 15 | null | null | null | [OBJECTIVE] To compare scales measuring exercise-induced changes in mood. [METHODS] Mood changes in a randomized, 23-week controlled trial of exercise were assessed using the Beck Depression Inventory (BDI), Center for Epidemiologic Studies Depression Scale (CES-D), State Trait Anxiety Inventory (STAI), Fibromyalgia Im... | null | null | null | null | null | null |
12,616,207 | Distribution of respiratory mucin proteins in human nasal mucosa. | The Laryngoscope | Laryngoscope | 113 | 3 | 10.1097/00005537-200303000-00023 | eng | 2,003 | 3 | null | null | null | null | [OBJECTIVES/HYPOTHESIS] The upper respiratory tract is involved in many acute and chronic respiratory tract diseases that present with the symptom of mucus hypersecretion. Mucin genes that encode for the backbone of glycoproteins contribute to the viscoelastic property of airway mucus. We examined the cellular expressi... | null | 1.415 | 183 | Otorhinolaryngology | Medicine | 2,003 |
12,616,141 | Patients' preference of valacyclovir once-daily suppressive therapy versus twice-daily episodic therapy for recurrent genital herpes: a randomized study. | Sexually transmitted diseases | Sex Transm Dis | 30 | 3 | 10.1097/00007435-200303000-00010 | eng | 2,003 | 3 | null | null | null | null | [BACKGROUND] Valacyclovir is effective for suppressive and episodic treatment of recurrent genital herpes. Few data on patients' treatment strategy preferences are available. [GOAL] The goal was to assess patients' preference, satisfaction, and quality of life with suppressive versus episodic treatment of recurrent gen... | null | 1.26 | 115 | Dermatology; Infectious Diseases; Microbiology; Public Health, Environmental and Occupational Health | Medicine | 2,003 |
12,615,832 | Ultrasound examination of polycystic ovaries: is it worth counting the follicles? | Human reproduction (Oxford, England) | Hum Reprod | 18 | 3 | 10.1093/humrep/deg115 | eng | 2,003 | 3 | null | null | null | null | [BACKGROUND] This study revisited the ultrasonographic diagnostic criteria of polycystic ovary syndrome (PCOS) and studied the relationship between the major hormonal and metabolic features of PCOS and the follicle number per ovary (FNPO). [METHODS] This prospective study included 214 women with PCOS compared with 112 ... | null | 1.688 | 264 | Obstetrics and Gynecology; Rehabilitation; Reproductive Medicine | Medicine | 2,003 |
12,615,669 | Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. | Arteriosclerosis, thrombosis, and vascular biology | Arterioscler Thromb Vasc Biol | 23 | 4 | 10.1161/01.ATV.0000062884.69432.A0 | eng | 2,003 | 4 | 1 | 2,003 | 2 | 20 | [OBJECTIVE] Epidemiology suggests that Mediterranean diets are associated with reduced risk of cardiovascular disease. Because monocyte adhesion to the endothelium is crucial in early atherogenesis, we evaluated whether typical olive oil and red wine polyphenols affect endothelial-leukocyte adhesion molecule expression... | null | 3.551 | 301 | Cardiology and Cardiovascular Medicine | Medicine | 2,003 |
12,615,592 | Patient satisfaction data as a quality indicator: a tale of two emergency departments. | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | Acad Emerg Med | 10 | 3 | 10.1111/j.1553-2712.2003.tb02000.x | eng | 2,003 | 3 | null | null | null | null | [OBJECTIVE] Patient satisfaction is a commonly measured indicator of quality emergency care. However, the existing empirical literature on emergency department (ED) patient satisfaction provides little guidance on how to analyze, interpret, and use data obtained in the clinical setting. Using two EDs as examples, the a... | null | 0.99 | 148 | Emergency Medicine; Medicine | Medicine | 2,003 |
12,614,553 | Histological alterations after irradiation of cartilage using Ho:YAG laser. | Journal of clinical laser medicine & surgery | J Clin Laser Med Surg | 21 | 1 | 10.1089/10445470360516671 | eng | 2,003 | 2 | null | null | null | null | [OBJECTIVE] The authors carried out an experimental study to evaluate the histological alterations after irradiation of cartilage using Holmium:YAG (Ho:YAG) laser VersaPulse Select 60 watts and Infra Tome Delivery Systems 30 degrees Handpiece (spot size at fiber tip 0.4 mm; Coherent Medical, Palo Alto, CA). [BACKGROUND... | null | null | null | null | null | null |
12,614,387 | Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA. | Epilepsia | Epilepsia | 44 | 3 | 10.1046/j.1528-1157.2003.07202.x | eng | 2,003 | 3 | null | null | null | null | [PURPOSE] Valproic acid (VPA) is an antiepileptic drug (AED) used for generalized and absence seizures. It has a rare but potentially fatal hepatotoxicity side effect, and many researchers believe that reactive metabolites of VPA could be involved. We demonstrated here that the thiol conjugates of (E)-2,4-diene VPA wer... | null | 1.473 | 228 | Neurology; Neurology | Medicine; Neuroscience | 2,003 |
12,614,312 | Personality traits in multiple sclerosis (MS) patients with and without fatigue experience. | Acta neurologica Scandinavica | Acta Neurol Scand | 107 | 3 | 10.1034/j.1600-0404.2003.02037.x | eng | 2,003 | 3 | null | null | null | null | [OBJECTIVES] To determine the impact of personality characteristics on feelings of fatigue in multiple sclerosis (MS) patients and to compare the results with the impact of bodily impairment. [PATIENTS AND METHODS] Eighty patients with definite MS (mean age 38.5 +/- 9.0 years, 62 females) were surveyed using questionna... | null | 0.608 | 114 | Medicine; Neurology; Neurology | Medicine; Neuroscience | 2,003 |
12,612,903 | Interferon-alpha 2b plus ribavirin in patients with chronic hepatitis C after liver transplantation: a randomized study. | Gastroenterology | Gastroenterology | 124 | 3 | 10.1053/gast.2003.50095 | eng | 2,003 | 3 | null | null | null | null | [BACKGROUND AND AIMS] Hepatitis C virus (HCV) reinfection after liver transplantation is frequent and leads to chronic hepatitis and cirrhosis. The use of antiviral therapy in this situation remains controversial. This study aimed to assess the safety and efficacy of interferon alfa-2b plus ribavirin for recurrent hepa... | null | 3.421 | 482 | Gastroenterology | Medicine | 2,003 |
12,612,621 | Evaluation of sprint exercise testing protocols in wheelchair athletes. | Spinal cord | Spinal Cord | 41 | 3 | 10.1038/sj.sc.3101416 | eng | 2,003 | 3 | null | null | null | null | [STUDY DESIGN] Comparison of five different exercise testing protocols with different speeds on a treadmill with seven wheelchair athletes. [OBJECTIVE] To determine which speed and duration in an exercise protocol is best to test wheelchair athletes performing sprint races on a track. [SETTING] Swiss Paraplegic Centre,... | null | 0.681 | 131 | Medicine; Neurology; Neurology | Medicine; Neuroscience | 2,003 |
12,611,842 | Inferior frontal white matter anisotropy and negative symptoms of schizophrenia: a diffusion tensor imaging study. | The American journal of psychiatry | Am J Psychiatry | 160 | 3 | 10.1176/appi.ajp.160.3.572 | eng | 2,003 | 3 | null | null | null | null | [OBJECTIVE] The purpose of this study was test the hypothesis that abnormalities of inferior frontal white matter are related to the negative symptoms of schizophrenia. [METHOD] Fractional anisotropy of white matter tracts in the prefrontal area of 10 schizophrenic patients was determined by diffusion tensor imaging. P... | null | 4.518 | 405 | Psychiatry and Mental Health | Medicine | 2,003 |
12,610,097 | Increased Nox2 expression in human cardiomyocytes after acute myocardial infarction. | Journal of clinical pathology | J Clin Pathol | 56 | 3 | 10.1136/jcp.56.3.194 | eng | 2,003 | 3 | null | null | null | null | [BACKGROUND/AIMS] Recent studies indicate the presence of reactive oxygen species (ROS) producing homologues of the enzymatic subunit (Nox2) of phagocytic NADPH oxidase in non-phagocytic cells. Interestingly, in these cells, ROS produced by the Nox2 homologue(s) was shown to play a role in various regulatory processes,... | null | 0.821 | 158 | Medicine; Pathology and Forensic Medicine | Medicine | 2,003 |
12,610,057 | Value of coronary artery calcium scanning by computed tomography for predicting coronary heart disease in diabetic subjects. | Diabetes care | Diabetes Care | 26 | 3 | 10.2337/diacare.26.3.905 | eng | 2,003 | 3 | null | null | null | null | [OBJECTIVE] The South Bay Heart Watch is a cohort study designed to determine the significance of coronary calcium in high-risk asymptomatic patients. This is a report of the relative risk (RR) for outcomes of coronary artery calcium in diabetic and nondiabetic subjects. [RESEARCH DESIGN AND METHODS] A total of 1312 di... | null | 3.169 | 433 | Advanced and Specialized Nursing; Endocrinology, Diabetes and Metabolism; Internal Medicine | Medicine; Nursing | 2,003 |
12,610,032 | Unadjusted and adjusted prevalence of diagnosed depression in type 2 diabetes. | Diabetes care | Diabetes Care | 26 | 3 | 10.2337/diacare.26.3.744 | eng | 2,003 | 3 | null | null | null | null | [OBJECTIVE] To estimate the prevalence of diagnosed depression in a large population of individuals with type 2 diabetes, compared to a matched control group, and to estimate the extent of depression that is independently associated with diabetes. [RESEARCH DESIGN AND METHODS] We compared the prevalence of diagnosed de... | null | 3.169 | 433 | Advanced and Specialized Nursing; Endocrinology, Diabetes and Metabolism; Internal Medicine | Medicine; Nursing | 2,003 |
12,609,008 | The activity of single vasoconstrictor nerve units in hypertension. | Acta physiologica Scandinavica | Acta Physiol Scand | 177 | 3 | 10.1046/j.1365-201X.2003.01082.x | eng | 2,003 | 3 | null | null | null | null | [AIM] It has long been established from controlled experiments in anaesthetized animals that it is more accurate to quantify the mean frequency of efferent sympathetic nerve activity from single unit than from multi-unit bursts recordings. More recently, sympathetic nerve hyperactivity has been reported in patients wit... | null | null | null | null | null | null |
12,608,991 | Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone. | Acta physiologica Scandinavica | Acta Physiol Scand | 177 | 3 | 10.1046/j.1365-201X.2003.01070.x | eng | 2,003 | 3 | null | null | null | null | [AIM] Neurons in the rostral ventrolateral medulla (RVLM) that project directly to sympathetic preganglionic neurons in the spinal cord play a critical role in maintaining tonic activity in sympathetic vasomotor nerves. Intracellular recordings in vivo from putative RVLM presympathetic neurons have demonstrated that un... | null | null | null | null | null | null |
12,608,679 | Subantroscopic laterobasal sinus floor augmentation (SALSA): an up-to-5-year clinical study. | The International journal of oral & maxillofacial implants | Int J Oral Maxillofac Implants | 18 | 1 | null | eng | 2,003 | null | null | null | null | null | [PURPOSE] The aim of the article was to introduce a new subantroscopic laterobasal sinus augmentation (SALSA) tecnique as a minimally invasive approach to maxillary peri-implant surgery. [MATERIALS AND METHODS] The SALSA technique consists of the following steps: (1) microsurgical opening of the subantral space (SAS) w... | null | null | null | null | null | null |
12,608,645 | CD40 ligation triggers COX-2 expression in endothelial cells: evidence that CD40-mediated IL-6 synthesis is COX-2-dependent. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] | Inflamm Res | 52 | 1 | 10.1007/s000110300009 | eng | 2,003 | 1 | null | null | null | null | [OBJECTIVE] To investigate whether CD40-CD154 interactions on HUVEC can trigger COX-2 synthesis as well as PGE2 and PGI2 secretion in vitro and explore whether the CD40-triggered prostanoids provide costimulatory signals for IL-6 secretion in this cell type. [MATERIALS AND METHODS] COX-2 protein expression was examined... | null | 0.622 | 112 | Pharmacology; Immunology | Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics | 2,003 |
12,608,540 | Microsomal cytochrome P450 levels and activities of isolated rat livers perfused with albumin. | Pharmaceutical research | Pharm Res | 20 | 1 | 10.1023/a:1022202926073 | eng | 2,003 | 1 | null | null | null | null | [PURPOSE] We recently showed that the perfusion of isolated rat livers with perfusates containing bovine serum albumin (BSA) would significantly stimulate the release of tumor necrosis factor (TNF)-alpha. Here, we hypothesize that BSA-induced increase in the release of TNF-alpha, and possibly other cytokines, would aff... | null | 1.17 | 235 | Biotechnology; Organic Chemistry; Pharmaceutical Science; Pharmacology; Pharmacology; Molecular Medicine | Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,003 |
12,607,764 | Glutathione peroxidase levels throughout normal pregnancy and in pre-eclampsia. | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | J Matern Fetal Neonatal Med | 12 | 5 | 10.1080/jmf.12.5.322.326 | eng | 2,002 | 11 | null | null | null | null | [OBJECTIVE] Evidence suggests that hemoglobin, in addition to its function as a carrier of oxygen, also serves to transport nitric oxide, as S-nitroso cysteine, from the lungs to the peripheral circulation, where it can be released. Glutathione peroxidase, besides being an important antioxidant, is known to catalyze th... | null | null | null | null | null | null |
12,605,985 | Radiation therapy depletes extrachromosomally amplified drug resistance genes and oncogenes from tumor cells via micronuclear capture of episomes and double minute chromosomes. | International journal of radiation oncology, biology, physics | Int J Radiat Oncol Biol Phys | 55 | 4 | 10.1016/s0360-3016(02)04473-5 | eng | 2,003 | 3 | 15 | null | null | null | [PURPOSE] To determine if clinically relevant doses of ionizing radiation are capable of inducing extrachromosomal DNA loss in transformed human cell lines. [MATERIALS AND METHODS] The multidrug-resistant (MDR) human epidermoid KB-C1 cell line and the human neuroendocrine colon carcinoma line COLO320, which contain ext... | null | 2.258 | 286 | Cancer Research; Oncology; Radiation; Radiology, Nuclear Medicine and Imaging | Biochemistry, Genetics and Molecular Biology; Medicine; Physics and Astronomy | 2,003 |
12,605,969 | Myocardial perfusion changes in patients irradiated for left-sided breast cancer and correlation with coronary artery distribution. | International journal of radiation oncology, biology, physics | Int J Radiat Oncol Biol Phys | 55 | 4 | 10.1016/s0360-3016(02)04156-1 | eng | 2,003 | 3 | 15 | null | null | null | [PURPOSE] To evaluate postradiation regional heart perfusion changes with single photon emission tomography (SPECT) myocardial perfusion imaging in 69 patients treated with tangential photon beams radiation therapy (RT) for left-sided breast cancer. To correlate SPECT changes with percent irradiated left ventricle (LV)... | null | 2.258 | 286 | Cancer Research; Oncology; Radiation; Radiology, Nuclear Medicine and Imaging | Biochemistry, Genetics and Molecular Biology; Medicine; Physics and Astronomy | 2,003 |
12,605,641 | How accurate are subjective judgements of a continuum? | Histopathology | Histopathology | 42 | 3 | 10.1046/j.1365-2559.2003.01566.x | eng | 2,003 | 3 | null | null | null | null | [AIMS] To assess the accuracy of subjective judgements of a uni-dimensional continuum. [METHODS AND RESULTS] Twenty-four observers were asked to estimate the position of a dot placed between two lines using a 100-point scale. Each observer judged 20 different positions. Ninety-five percent of observations were between ... | null | 1.118 | 145 | Histology; Medicine; Pathology and Forensic Medicine | Medicine | 2,003 |
12,605,530 | Rigid external distraction osteogenesis for a patient with maxillary hypoplasia and oligodontia. | The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association | Cleft Palate Craniofac J | 40 | 2 | 10.1597/1545-1569_2003_040_0207_redofa_2.0.co_2 | eng | 2,003 | 3 | null | null | null | null | [OBJECTIVE] In this report, the orthodontic treatment combined with rigid external distraction osteogenesis in a 5.5-year-old girl with midfacial hypoplasia and oligodontia is described. [PATIENT] The child presented with a reduced maxilla, protruding lower lip, skeletal Class III jaw relationship with a low mandibular... | null | 0.677 | 96 | Otorhinolaryngology; Oral Surgery | Dentistry; Medicine | 2,003 |
12,605,524 | Is isolated palatal anomaly an indication to screen for 22q11 region deletion? | The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association | Cleft Palate Craniofac J | 40 | 2 | 10.1597/1545-1569_2003_040_0176_iipaai_2.0.co_2 | eng | 2,003 | 3 | null | null | null | null | [OBJECTIVE] Velocardiofacial syndrome (VCFS) is the most common multiple anomaly disorder associated with palatal clefting. Cytogenetic hemizygous deletion of 22q11 region is found in 80% of patients. The frequency of 22q11 deletion in patients presenting with isolated palatal anomalies has not been fully assessed. Our... | null | 0.677 | 96 | Otorhinolaryngology; Oral Surgery | Dentistry; Medicine | 2,003 |
12,605,120 | T-cell receptor beta-chain usage in directly activated alloreactive CD4+ T cells: unrestricted Vbeta gene usage with CDR3 size limitations. | Transplantation | Transplantation | 75 | 4 | 10.1097/01.TP.0000046939.45400.43 | eng | 2,003 | 2 | 27 | null | null | null | [BACKGROUND] Alloreactive immune responses may engage both direct and indirect antigen allorecognition. This study focuses on T-cell receptor (TCR) beta-chain usage by in vitro generated alloreactive CD4+ T cells involved in direct allorecognition pathway. [METHODS AND RESULTS] We have established Lewis anti-Brown Norw... | null | 1.519 | 224 | Transplantation | Medicine | 2,003 |
12,604,916 | Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients. | Pancreas | Pancreas | 26 | 2 | 10.1097/00006676-200303000-00014 | eng | 2,003 | 3 | null | null | null | null | [INTRODUCTION] Glucose intolerance or overt diabetes occurs in 80% of patients with pancreatic cancer (PC). This associated metabolic disorder includes peripheral insulin resistance, which may be caused by factors produced by the PC. The mechanism underlying PC-associated insulin resistance has not been clearly defined... | null | 0.704 | 123 | Internal Medicine; Endocrinology; Endocrinology, Diabetes and Metabolism; Hepatology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,003 |
12,604,913 | Ultrastructural study of the pancreas in AIDS. | Pancreas | Pancreas | 26 | 2 | 10.1097/00006676-200303000-00011 | eng | 2,003 | 3 | null | null | null | null | [INTRODUCTION] Frequent histologic changes (90%) in the pancreas suggesting protein-energy malnutrition were found in a previous necropsy study of pancreas morphology in patients with AIDS. However, additional studies were required to clarify subcellular changes. [AIM] To ultrastructurally analyze pancreas changes in A... | null | 0.704 | 123 | Internal Medicine; Endocrinology; Endocrinology, Diabetes and Metabolism; Hepatology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,003 |
12,603,532 | Role of para-esophageal collateral veins in patients with portal hypertension based on the results of endoscopic ultrasonography and liver scintigraphy analysis. | Journal of gastroenterology and hepatology | J Gastroenterol Hepatol | 18 | 3 | 10.1046/j.1440-1746.2003.02956.x | eng | 2,003 | 3 | null | null | null | null | [BACKGROUND AND AIMS] Para-esophageal collateral veins (para-ECV) are observed by endoscopic ultrasonography (EUS) in patients with portal hypertension. However, the role of para-ECV in the portal venous system is not clear. To verify the role of para-ECV in the portal venous system, we investigated the relationship be... | null | 0.579 | 156 | Gastroenterology; Hepatology | Medicine | 2,003 |
12,601,540 | Loco-regional failures in head and neck cancer: can they be effectively salvaged by nonsurgical therapeutic modalities? | International journal of clinical oncology | Int J Clin Oncol | 8 | 1 | 10.1007/s101470300004 | eng | 2,003 | 2 | null | null | null | null | [BACKGROUND] This retrospective study was carried out to ascertain the extent of efficacy of nonsurgical salvage modalities, mainly chemotherapy (CT) alone or chemoradiotherapy (CTRT), for loco-regional failures in head and neck cancer (HNC). [METHODS] Between 1991 and 1999, 131 patients with HNC, mostly stages III and... | null | 0.338 | 78 | Medicine; Surgery; Hematology; Oncology | Medicine | 2,003 |
12,601,405 | Establishing a Maori case management clinic. | The New Zealand medical journal | N Z Med J | 116 | 1169 | null | eng | 2,003 | 2 | 21 | 2,003 | 2 | 21 | [AIMS] The Maori Case Management Clinic Project aims to improve Maori health outcomes by establishing low cost, high quality, culturally appropriate primary care facilities in targeted areas, with a focus on the management of chronic illness. Further, the project aims to evaluate this 'by Maori for Maori' model of comm... | null | 0.34 | 60 | Medicine | Medicine | 2,003 |
12,600,961 | Low-positive anti-hepatitis C virus enzyme immunoassay results: an important predictor of low likelihood of hepatitis C infection. | Clinical chemistry | Clin Chem | 49 | 3 | 10.1373/49.3.479 | eng | 2,003 | 3 | null | null | null | null | [BACKGROUND] Tests for hepatitis C antibodies (anti-HCV enzyme immunoassays) are usually described as positive or negative. Several studies, mainly in blood donors, have found that specimens with low signal/cutoff (S/C) ratios are commonly negative when tested with a recombinant immunoblot assay (RIBA) or for HCV RNA. ... | null | 1.329 | 248 | Biochemistry; Clinical Biochemistry | Biochemistry, Genetics and Molecular Biology; Medicine | 2,003 |
12,599,236 | Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features. | Cancer | Cancer | 97 | 5 | 10.1002/cncr.11187 | eng | 2,003 | 3 | 1 | null | null | null | [BACKGROUND] Patients who have oligodendrogliomas (OD) that demonstrate loss of both 1p and 19q appear to have a better prognosis after they receive chemotherapy and radiotherapy compared with patients who have OD without these characteristics. It is unclear whether this improvement in outcome is due only to a better r... | null | 1.864 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,003 |
12,599,223 | Pure versus follicular variant of papillary thyroid carcinoma: clinical features, prognostic factors, treatment, and survival. | Cancer | Cancer | 97 | 5 | 10.1002/cncr.11175 | eng | 2,003 | 3 | 1 | null | null | null | [BACKGROUND] The follicular variant of papillary thyroid carcinoma (FVPTC) is a common subtype of papillary thyroid carcinoma. Few studies have compared the clinical behavior and treatment outcome of patients with FVPTC with the outcome of patients with pure papillary carcinoma (PTC). A retrospective study was performe... | null | 1.864 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,003 |
12,598,770 | Perforin expression in T cells and virological response to PEG-interferon alpha2b in HIV-1 infection. | AIDS (London, England) | AIDS | 17 | 4 | 10.1097/00002030-200303070-00005 | eng | 2,003 | 3 | 7 | null | null | null | [OBJECTIVE AND DESIGN] Interferon alpha (IFNalpha), which is known to directly inhibit the HIV-1 replicative cycle and to increase the activity of cytotoxic T lymphocytes (CTL), is being tested as an anti-HIV agent. As CTL play a major role in immune defence against HIV, we wanted to further characterize CTL activity a... | null | 2.74 | 233 | Immunology; Immunology and Allergy; Infectious Diseases | Immunology and Microbiology; Medicine | 2,003 |
12,598,069 | Atriobiventricular pacing improves exercise capacity in patients with heart failure and intraventricular conduction delay. | Journal of the American College of Cardiology | J Am Coll Cardiol | 41 | 4 | 10.1016/s0735-1097(02)02849-8 | eng | 2,003 | 2 | 19 | null | null | null | [OBJECTIVES] We sought to assess the efficacy of biventricular pacing with respect to both peak and submaximal measures of exercise in patients with New York Heart Association class III heart failure (HF) and intraventricular conduction delay in a randomized, blinded study. [BACKGROUND] Submaximal and maximal changes i... | null | 4.605 | 512 | Cardiology and Cardiovascular Medicine | Medicine | 2,003 |
12,597,781 | Human CD81 directly enhances Th1 and Th2 cell activation, but preferentially induces proliferation of Th2 cells upon long-term stimulation. | BMC immunology | BMC Immunol | 4 | null | 10.1186/1471-2172-4-1 | eng | 2,003 | 2 | 19 | 2,003 | 2 | 19 | [BACKGROUND] CD81, a cell-surface protein of the tetraspanin superfamily, has been shown to costimulate T cell activation in murine T cells, and is involved in development of Th2 immune responses in mice. [RESULTS] Here it is shown that stimulation of CD81 on human T cells can enhance T cell activation by antigen or su... | null | 1.163 | 76 | Immunology | Immunology and Microbiology | 2,003 |
12,597,753 | Maternal immunity and prevention of congenital cytomegalovirus infection. | JAMA | JAMA | 289 | 8 | 10.1001/jama.289.8.1008 | eng | 2,003 | 2 | 26 | null | null | null | [CONTEXT] Vaccine development to prevent congenital cytomegalovirus (CMV) infection has been impeded by the uncertainty over whether maternal immunity protects the fetus. [OBJECTIVE] To determine whether the presence of maternal antibodies to CMV significantly reduces the risk of congenital CMV infection in future preg... | null | null | null | null | null | null |
12,595,857 | Postexercise hypotension differs between white and black women. | American heart journal | Am Heart J | 145 | 2 | 10.1067/mhj.2003.107 | eng | 2,003 | 2 | null | null | null | null | [BACKGROUND] Because data are lacking, we examined the acute effect of exercise on ambulatory blood pressure (BP) in premenopausal white women (n = 18) and black women (n = 15) with normal (n = 21) and high (n = 12) BP. [METHODS] Women performed 40 minutes of control and moderate-intensity exercise. BP and hormones wer... | null | 1.95 | 211 | Cardiology and Cardiovascular Medicine | Medicine | 2,003 |
12,593,794 | The staufen/pumilio pathway is involved in Drosophila long-term memory. | Current biology : CB | Curr Biol | 13 | 4 | 10.1016/s0960-9822(03)00064-2 | eng | 2,003 | 2 | 18 | null | null | null | [BACKGROUND] Memory formation after olfactory learning in Drosophila displays behavioral and molecular properties similar to those of other species. Particularly, long-term memory requires CREB-dependent transcription, suggesting the regulation of "downstream" genes. At the cellular level, long-lasting synaptic plastic... | null | null | null | null | null | null |
12,593,608 | High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients. | Journal of periodontology | J Periodontol | 74 | 1 | 10.1902/jop.2003.74.1.129 | eng | 2,003 | 1 | null | null | null | null | [BACKGROUND] Helicobacter pylori has been associated with the development of peptic ulcers and gastric cancer. Although it may be transmitted through the oral cavity, it is unknown whether the oral cavity acts as a permanent reservoir for this bacterium. The purpose of this study was to use nested polymerase chain reac... | null | 1.277 | 186 | Periodontics | Dentistry | 2,003 |
12,592,646 | The prevalence of coeliac disease in Libyan children with type 1 diabetes mellitus. | Diabetes/metabolism research and reviews | Diabetes Metab Res Rev | 19 | 1 | 10.1002/dmrr.333 | eng | 2,003 | null | null | null | null | null | [BACKGROUND] Diagnosis of atypical and silent forms of coeliac disease (CD) is important because of its serious complications. Increased prevalence of coeliac disease worldwide in individuals with type 1 diabetes mellitus (DM) was described. There are no data on the prevalence of CD in the Libyan population and Libyan ... | null | 1.08 | 141 | Endocrinology; Endocrinology, Diabetes and Metabolism; Internal Medicine | Biochemistry, Genetics and Molecular Biology; Medicine | 2,003 |
12,592,128 | In-111 DTPA-octreotide scintigraphy for disease detection in metastatic thyroid cancer: comparison with F-18 FDG positron emission tomography and extensive conventional radiographic imaging. | Clinical nuclear medicine | Clin Nucl Med | 28 | 3 | 10.1097/01.RLU.0000053409.18088.46 | eng | 2,003 | 3 | null | null | null | null | [PURPOSE] The utility of In-111 DTPA octreotide scintigraphy (SRS) for disease detection in patients with metastatic thyroid carcinoma (TCA) remains controversial. The authors compared the sensitivity of In-111-based SRS, F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET), and extensive conventional radio... | null | 0.356 | 73 | Medicine; Radiology, Nuclear Medicine and Imaging | Medicine | 2,003 |
12,592,062 | Body composition modulates the effects of hormone replacement therapy on growth hormone and insulin-like growth factor-I levels in postmenopausal women. | Gynecologic and obstetric investigation | Gynecol Obstet Invest | 54 | 4 | 10.1159/000068383 | eng | 2,002 | null | null | null | null | null | [OBJECTIVE] To examine the relationships of body composition with basal serum estrone, estradiol, androstenedione, cortisol, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in 73 postmenopausal women. [DESIGN] Cross-sectional study of hormone levels and body composition determined by dual-energy X-r... | null | 0.512 | 74 | Obstetrics and Gynecology; Reproductive Medicine | Medicine | 2,002 |
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