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40,049,732
Novel Instruments for Full Endoscopic Trans-Kambin Triangle Lumbar Interbody Fusion With Reverse Oblique Lateral Cage Insertion: A Case Report and Technical Note.
International journal of spine surgery
Int J Spine Surg
19
1
10.14444/8695
eng
2,025
3
6
2,025
3
6
[BACKGROUND] Lumbar interbody fusion with screw fixation is a standard treatment for lumbar degenerative diseases. While full-endoscopic lumbar interbody fusion is minimally invasive, it utilizes smaller cages compared with the oblique lateral interbody fusion (OLIF) technique, which offers superior biomechanical suppo...
degenerative spinal disease; endoscopic fusion surgery; full-endoscopic-KLIF; novel spine technique; reverse oblique lateral interbody fusion
0.748
40
Surgery; Orthopedics and Sports Medicine
Medicine
2,024
40,049,729
Physician associates and anaesthetic associates in UK: rapid systematic review of recent UK based research.
BMJ (Clinical research ed.)
BMJ
388
null
10.1136/bmj-2025-084613
eng
2,025
3
6
2,025
3
6
[OBJECTIVE] To summarise research on the efficacy and safety of UK physician associates and anaesthetic associates in the context of an ongoing policy review. [DESIGN] Rapid systematic review. [SEARCH STRATEGY] Keyword and author search of three databases; citation tracking; search of previous systematic reviews. [ELIG...
null
2.976
519
Medicine
Medicine
2,024
40,049,551
An 8-Year Experience of Robot-Assisted Laparoscopic Surgical Management of Median Arcuate Ligament Syndrome.
Annals of vascular surgery
Ann Vasc Surg
114
null
10.1016/j.avsg.2025.01.039
eng
2,025
5
null
2,025
3
4
[BACKGROUND] Due to the rarity of median arcuate ligament syndrome (MALS), surgical approaches to median arcuate ligament release (MALR) have been understudied. This series aimed to review robot-assisted laparoscopic MALR from a quaternary care center. [METHODS] This is a single-center cohort study of adult patients wh...
null
0.707
87
Cardiology and Cardiovascular Medicine; Medicine; Surgery
Medicine
2,024
40,049,327
Early Cost-Effectiveness Analysis of Using Whole-Genome Sequencing for Patients With Castration-Resistant Prostate Cancer.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
Value Health
28
5
10.1016/j.jval.2025.02.004
eng
2,025
5
null
2,025
3
4
[OBJECTIVES] This study aims to assess the potential cost-effectiveness of using whole-genome sequencing (WGS)-guided systemic therapy in metastatic castrate-resistant prostate cancer compared with the European Association of Urology guideline recommended diagnostics from a Dutch societal perspective. [METHODS] A decis...
biomarker-guided therapy; castrate-resistant prostate cancer; cost-effectiveness; incremental cost-effectiveness ratio; whole-genome sequencing
1.856
138
Health Policy; Medicine; Public Health, Environmental and Occupational Health
Medicine
2,024
40,049,088
Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway.
International immunopharmacology
Int Immunopharmacol
152
null
10.1016/j.intimp.2025.114394
eng
2,025
4
16
2,025
3
5
[BACKGROUND] Reports on the expression of CD200 in monocytes are scarce, and the role of monocytes in patients with myelodysplastic syndrome (MDS) remains unclear. Additionally, monocytes have been implicated in suppressing NK cell function. Therefore, this study aimed to explore the possible mechanism by which monocyt...
CD200R; ERK; MDS; Monocytes; NK cells
1.239
155
Pharmacology; Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine; Pharmacology, Toxicology and Pharmaceutics
2,024
40,049,068
Post-treatment monitoring of surgically treated oropharyngeal squamous cell carcinoma patients using human papillomavirus cell-free DNA.
Oral oncology
Oral Oncol
163
null
10.1016/j.oraloncology.2025.107225
eng
2,025
4
null
2,025
3
5
[INTRODUCTION] The incidence rate of human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Despite good prognosis, recurrence can decrease health-related quality of life and increase mortality, so post-treatment monitoring is important for patient outcomes. One potential biomark...
null
1.326
143
Oncology; Oral Surgery; Cancer Research
Biochemistry, Genetics and Molecular Biology; Dentistry; Medicine
2,024
40,048,368
Disparities in Cardiovascular Disease Prevalence by Race and Ethnicity, Socioeconomic Status, Urbanicity, and Social Determinants of Health Among Medicare Beneficiaries With Diabetes.
Preventing chronic disease
Prev Chronic Dis
22
null
10.5888/pcd22.240270
eng
2,025
1
30
2,025
1
30
[INTRODUCTION] The association between various disparity factors and cardiovascular disease (CVD) prevalence among older US adults with diabetes has not been comprehensively explored. We examined disparities in CVD prevalence among Medicare beneficiaries with diabetes. [METHODS] Data were from the 2015-2019 Medicare Cu...
null
1.77
102
Health Policy; Public Health, Environmental and Occupational Health
Medicine
2,024
40,048,201
A privacy-preserving and low-cost system for preventing cheats in in-vehicle alcohol detection.
Traffic injury prevention
Traffic Inj Prev
null
null
10.1080/15389588.2025.2465821
eng
2,025
3
6
2,025
3
6
[OBJECTIVES] Young people are easily impulsive and influenced by their peers, so they lead to a high crash rate than adults when they consume alcohol. To forcibly prevent them from drunk driving is very important. Therefore, an in-vehicle system for preventing cheats in alcohol detection is innovatively designed accord...
Drunk driving prevention; alcohol ignition interlock; breath pressure; safety belt
0.566
69
Public Health, Environmental and Occupational Health; Safety Research
Medicine; Social Sciences
2,024
40,048,012
Consensus nonnegative matrix factorization reveals metastatic gene expression program and identifies E74-like ETS transcription factor 3 confers to the lymph nodes metastasis in papillary thyroid cancer.
Endocrine
Endocrine
88
3
10.1007/s12020-025-04205-y
eng
2,025
6
null
2,025
3
6
[BACKGROUND] Advanced papillary thyroid carcinoma (PTC) exhibits significant heterogeneity. Understanding the gene expression programs underlying tumor heterogeneity is crucial for improving diagnostic and therapeutic strategies. [METHODS] We integrated single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data to ex...
Consensus nonnegative matrix factorization; Drug sensitivity; ELF3; Gene expression programs; Lymph node metastasis
0.971
107
Endocrinology; Endocrinology, Diabetes and Metabolism
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,047,999
Perturbations in the neuroactive ligand-receptor interaction and renin angiotensin system pathways are associated with cancer-related cognitive impairment.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Support Care Cancer
33
4
10.1007/s00520-025-09317-9
eng
2,025
3
6
2,025
3
6
[PURPOSE] This study reports on the results from our data-driven approach that identified perturbations in neuroactive ligand-receptor interaction and renin-angiotensin system (RAS) pathways in oncology patients with and without self-reported cancer-related cognitive impairment (CRCI). [METHODS] In a sample of oncology...
Cancer; Chemotherapy; Cognitive dysfunction; Cognitive impairment; Neuroinflammation; Renin angiotensin system
1.109
143
Oncology; Rehabilitation; Oncology
Medicine; Nursing
2,024
40,047,083
Reliability and validity of the Persian version of the Fatigue Scale for Motor and Cognitive Functions (P-FSMC) in Iranian people with multiple sclerosis.
Disability and rehabilitation
Disabil Rehabil
null
null
10.1080/09638288.2025.2466716
eng
2,025
3
6
2,025
3
6
[PURPOSE] This study evaluated the psychometric feature of the Persian version of the Fatigue Scale for Motor and Cognitive Functions (P-FSMC) in Iranian People with Multiple Sclerosis (PwMS). [MATERIALS AND METHODS] In this cross-sectional study, 303 PwMS and 102 healthy controls participated. Structural validity was ...
Multiple sclerosis; fatigue; questionnaire; reliability; validity
0.972
140
Rehabilitation
Medicine
2,024
40,046,983
Assessment of Positional Obstructive Sleep Apnea in Children Undergoing Adenotonsillectomy for Obstructive Sleep Apnea.
Laryngoscope investigative otolaryngology
Laryngoscope Investig Otolaryngol
10
2
10.1002/lio2.70116
eng
2,025
4
null
2,025
3
4
[OBJECTIVES] To determine the prevalence of positional obstructive sleep apnea (pOSA) in children undergoing adenotonsillectomy (AT) for OSA and to assess whether pOSA improves following AT. [MATERIALS AND METHODS] Children with OSA diagnosed by polysomnography (PSG) at a tertiary care children's hospital were included...
children; obstructive sleep apnea; persistent obstructive sleep apnea; positional obstructive sleep apnea
0.641
42
Otorhinolaryngology; Surgery
Medicine
2,024
40,046,940
Bioinformatics Analysis of Oxidative Stress-Related Genes and Immune Infiltration Patterns in Vitiligo.
Clinical, cosmetic and investigational dermatology
Clin Cosmet Investig Dermatol
18
null
10.2147/CCID.S496781
eng
2,025
null
null
2,025
2
28
[BACKGROUND] Vitiligo is an autoimmune disorder characterized by pigment loss, and current treatment options remain inadequate. [OBJECTIVE] This study aims to identify oxidative stress-related biomarkers and hub genes associated with vitiligo diagnosis through genomic analysis and to examine the role of immune cell inf...
DCT; DEGs; hub gene; immune infiltration; oxidative stress; vitiligo
0.737
59
Dermatology
Medicine
2,024
40,046,776
Rural community pharmacists' willingness to receive, administer, and recommend COVID-19 vaccines after the First U.S. vaccine rollout.
Exploratory research in clinical and social pharmacy
Explor Res Clin Soc Pharm
16
null
10.1016/j.rcsop.2024.100520
eng
2,024
12
null
2,024
10
5
[INTRODUCTION] Vaccines remain the cornerstone for prevention of COVID-19. Particularly in rural areas, community pharmacists are among the most accessible healthcare professionals. Their advocacy for immunization can help overcome patients' vaccine hesitancy and close the disparity gap between rural and urban regions....
COVID-19 vaccine; Community pharmacy; Pharmacist; Rural; Vaccine acceptance; Vaccine hesitancy
0.514
12
Pharmacy; Health, Toxicology and Mutagenesis; Pharmacology
Environmental Science; Health Professions; Medicine
2,024
40,046,755
Clinical effects of Bifidobacterium Longum Subsp. Infantis YLGB-1496 on children with respiratory symptoms.
Frontiers in nutrition
Front Nutr
12
null
10.3389/fnut.2025.1537610
eng
2,025
null
null
2,025
2
19
[OBJECTIVES] This study aimed to examine the effects of Bifidobacterium longum subsp. infantis YLGB-1496 (B. infantis YLGB-1496) on the frequency of respiratory illness symptoms and immunity profiles among toddlers. [METHODS] In this double-blind, randomized, placebo-controlled, 12-week intervention study, toddlers wit...
Bifidobacterium longum subsp. infantis YLGB-1496; immunological effects; randomized controlled trial; respiratory symptoms; toddlers
1.115
94
Food Science; Nutrition and Dietetics; Endocrinology, Diabetes and Metabolism
Agricultural and Biological Sciences; Medicine; Nursing
2,024
40,046,673
A signature combining brain functional connectivity with executive and motor function for general cognitive decline in Parkinson's disease.
Frontiers in neurology
Front Neurol
16
null
10.3389/fneur.2025.1434733
eng
2,025
null
null
2,025
2
19
[INTRODUCTION] Cognitive decline is common in Parkinson's disease (PD). Reliance on neuropsychological testing alone can lead to delayed identification, and an objective and comprehensive approach is needed in clinical practice. We assessed brain functional connectivity during PD-MCI (mild cognitive impairment) and PD-...
Stroop color-word test; cognitive decline; functional connectivity; functional near-infrared spectroscopy
0.993
118
Neurology; Neurology
Medicine; Neuroscience
2,024
40,046,640
Adherence and aerobic exercise intensity in live online exercise sessions for older adults with mild cognitive impairment: Insights from the Japan-Multimodal Intervention Trial for the Prevention of Dementia.
JAR life
JAR Life
14
null
10.1016/j.jarlif.2025.100003
eng
2,025
null
null
2,025
2
7
[BACKGROUND] Intervention adherence is crucial to ensure cognitive benefits in trials designed to prevent cognitive decline. During the coronavirus disease 2019 (COVID-19) pandemic, the Japan-Multimodal Intervention Trial for the Prevention of Dementia offered live online exercise sessions to older adults with mild cog...
Adherence; Exercise; Mild cognitive impairment; Multidomain intervention; Online
null
null
null
null
null
40,046,531
Identification of risk factors for postoperative complications after right colectomy and low anterior resection in patients ≥85 years old with colorectal cancer using the National Clinical Database.
Annals of gastroenterological surgery
Ann Gastroenterol Surg
9
2
10.1002/ags3.12876
eng
2,025
3
null
2,024
11
11
[AIM] The purpose of this study was to evaluate factors associated with surgical outcomes and postoperative complications (Grade ≥3 by Clavien-Dindo classification) of right hemicolectomy (RH) and low anterior resection (LAR) for colorectal cancer in patients ≥85 years old. [METHODS] We retrospectively analyzed Nationa...
National Clinical Database; elderly patients; low anterior resection; postoperative complications; right hemicolectomy
1.233
38
Gastroenterology; Surgery
Medicine
2,024
40,046,303
Analysis of fungal microbiota diversity and potential pathogenic fungi in oral secretions and gut feces of captive giant pandas.
Frontiers in microbiology
Front Microbiol
16
null
10.3389/fmicb.2025.1522289
eng
2,025
null
null
2,025
2
13
[BACKGROUND] Maintaining good oral and gut health is essential for the wellbeing of animals, and fungi are key components of the oral and gut microbiota. This study aims to explore the diversity and seasonal dynamics of oral and gut fungal communities in captive giant pandas, with a focus on their potential functional ...
giant panda; gut fungi; opportunistic pathogens; oral fungi; seasonality
1.172
259
Microbiology; Microbiology
Immunology and Microbiology; Medicine
2,024
40,046,261
Prevalence of Meeting Daily Step Count Recommendations in Cardiovascular Patients With and Without Metabolic Syndrome.
American journal of medicine open
Am J Med Open
13
null
10.1016/j.ajmo.2024.100084
eng
2,025
6
null
2,024
12
17
[PURPOSE] We compared the prevalence of older cardiovascular patients with and without metabolic syndrome (MetS) who met the recommendations of walking more than 7000 and 10,000 steps/d, and we determined whether MetS status was significantly associated with meeting the daily step count recommendations before and after...
Aging; Cardiovascular risk factors; Exercise; Physical activity; Walking
null
null
null
null
null
40,061,007
Assessing the Efficacy of Extended Postoperative Enoxaparin as Thromboprophylaxis for Patients Undergoing Laparoscopic Sleeve Gastrectomy: a Prospective Analysis.
Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia Herzegovina : casopis Drustva za medicinsku informatiku BiH
Acta Inform Med
32
3-4
10.5455/aim.2024.32.201-206
eng
2,024
null
null
null
null
null
[BACKGROUND] Venous thromboembolism (VTE), encompassing deep venous thrombosis (DVT) and pulmonary embolism (PE), presents significant morbidity and mortality risks post-bariatric surgery. Despite the recognized need for thromboprophylaxis, optimal strategies, particularly regarding the duration and dosing of chemoprop...
Enoxaparin; Laparoscopic Sleeve Gastrectomy (LSG); Postoperative Thromboprophylaxis; Prospective Cohort Study; Venous Thromboembolism (VTE)
null
null
null
null
null
40,097,257
Examining the impact of identity-safety cues on inclusion for adults with higher body weights in healthcare settings.
Patient education and counseling
Patient Educ Couns
134
null
10.1016/j.pec.2025.108652
eng
2,025
5
null
2,025
1
12
[OBJECTIVES] Adults with higher body weights experience weight stigma in healthcare, which can heighten concerns about treatment in these settings. This study investigates whether a specific strategy-using an identity-safety cue, or a cue which signals that one's social identity is valued-mitigates these concerns. [MET...
Allyship; Body weight; Identity-safety cues; Inclusive healthcare; Stigma
1.237
168
Medicine
Medicine
2,024
40,097,016
Glucose time in range trajectories during pregnancy and association with adverse perinatal outcomes: a joint latent-class trajectory modeling approach.
American journal of obstetrics & gynecology MFM
Am J Obstet Gynecol MFM
7
6
10.1016/j.ajogmf.2025.101669
eng
2,025
6
null
2,025
3
15
[BACKGROUND] While time in range (TIR) summarized over pregnancy is associated with adverse outcomes among individuals with preexisting type 1 or 2 diabetes, the impact of TIR trajectories with advancing gestation is unknown. [OBJECTIVE] To identify glucose TIR trajectories across pregnancy and evaluate their associati...
null
null
null
null
null
null
40,096,883
Progression of lymphatic filariasis antigenaemia and microfilaraemia over 4.5 years in antigen-positive individuals, Samoa 2019-2023.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Int J Infect Dis
155
null
10.1016/j.ijid.2025.107891
eng
2,025
6
null
2,025
3
15
[OBJECTIVES] The first round of triple-drug mass drug administration (MDA) for lymphatic filariasis (LF) in Samoa was in 2018. This study aims to i) examine progression of LF antigen (Ag) and microfilaria (Mf) in Ag-positive individuals from 2019-2023; and ii) compare Ag/Mf prevalence in household members of Mf-positiv...
Clustering; Neglected Tropical Disease elimination; Pacific Islands; Recrudescence; Wuchereria bancrofti
1.323
140
Infectious Diseases; Medicine; Microbiology
Medicine
2,024
40,096,882
Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Int J Infect Dis
154
null
10.1016/j.ijid.2025.107890
eng
2,025
5
null
2,025
3
15
[OBJECTIVES] To assess the risk factors associated with Helicobacter pylori infection in the urban Chinese population. [METHODS] The study was conducted from March to November 2023, including 12,902 urban participants aged 18-60 years across 52 cities distributed over 26 provinces in China. Risk factors included socioe...
Helicobacter pylori; Lifestyle; Public understanding; Risk factors; Socioeconomic status
1.323
140
Infectious Diseases; Medicine; Microbiology
Medicine
2,024
40,096,716
Training needs and learning objectives in Rehabilitation Practice for Family Medicine residents in Tunisia in 2024.
La Tunisie medicale
Tunis Med
103
2
10.62438/tunismed.v103i2.5268
eng
2,025
2
5
2,025
2
5
[INTRODUCTION] Family Medicine (FM) is undergoing global reform to address healthcare challenges and improve patient outcomes. Rehabilitation is a crucial component of primary care, yet FM training often lacks adequate emphasis on this area. [AIM] To determine the needs of FM residents in rehabilitation training and fo...
Curriculum; Delphi Method; Family Medicine; Rehabilitation; Resident; Tunisia
null
null
null
null
null
40,095,130
The Adult Separation Anxiety Questionnaire (ASA-27): reliability of the German translation, factor structure, and concurrent validity with anxiety sensitivity and agoraphobic cognition.
Der Nervenarzt
Nervenarzt
null
null
10.1007/s00115-025-01806-w
eng
2,025
3
17
2,025
3
17
[BACKGROUND] Separation anxiety disorder (SEPAD) is characterized by pronounced fear or anxiety concerning separation from attachment figures. Despite its high lifetime prevalence, adult SEPAD often remains undetected due to a lack of diagnostic tools in multiple languages. The Adult Separation Anxiety Questionnaire (A...
Anxiety Disorders; Diagnostics; Psychometrics; SEPAD; Separation Phobia
null
null
null
null
null
40,094,699
Automated Imaging Differentiation for Parkinsonism.
JAMA neurology
JAMA Neurol
82
5
10.1001/jamaneurol.2025.0112
eng
2,025
5
1
null
null
null
[IMPORTANCE] Magnetic resonance imaging (MRI) paired with appropriate disease-specific machine learning holds promise for the clinical differentiation of Parkinson disease (PD), multiple system atrophy (MSA) parkinsonian variant, and progressive supranuclear palsy (PSP). A prospective study is needed to test whether th...
null
null
null
null
null
null
40,094,276
Metabolomic profile associated with coronary artery disease: higher indoleamine 2,3-dioxygenase activity and lower tryptophan concentrations predict worse prognosis.
Polish archives of internal medicine
Pol Arch Intern Med
135
5
10.20452/pamw.16974
eng
2,025
5
29
2,025
3
14
[INTRODUCTION] Metabolite profiling can lead to novel discoveries in cardiovascular disease (CVD) physiology. [OBJECTIVES] The aim of the study was to investigate whether a metabolomic profile is associated with mortality in patients with coronary artery disease (CAD). [METHODS] The study group consisted of 170 partici...
null
0.554
48
Internal Medicine
Medicine
2,024
40,094,267
Validation and comparison of the molecular international prognostic scoring system (IPSS-M) and the revised international prognostic scoring system (IPSS-R) in myelodysplastic neoplasms (MDS): a retrospective study.
Hematology (Amsterdam, Netherlands)
Hematology
30
1
10.1080/16078454.2025.2479257
eng
2,025
12
null
2,025
3
17
[OBJECTIVES] To evaluate the prognostic value of the Molecular International Prognostic Scoring System (IPSS-M) compared to the Revised International Prognostic Scoring System (IPSS-R) in patients with myelodysplastic neoplasms (MDS) in the Jiangnan region of China. [METHODS] A retrospective multicenter study analyzed ...
IPSS-M; IPSS-R; myelodysplastic neoplasms (MDS); prognostic assessment; survival analysis
null
null
null
null
null
40,093,923
Factors associated with the delivery of specific physical activity advice to patients with non-communicable diseases by primary care physicians in Klang Valley, Malaysia: a cross-sectional study.
Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia
Malays Fam Physician
20
null
10.51866/oa.754
eng
2,025
null
null
2,025
2
21
[INTRODUCTION] Specific physical activity advice delivered to patients with non-communicable diseases (NCDs) improves physical activity levels and health outcomes. This study aimed to develop a physical activity advice tool and determine the physical activity level of primary care physicians, prevalence of physical act...
Exercise; Noncommunicable diseases; Physicians, Counseling; Primary health care
0.287
22
Community and Home Care; Family Practice
Medicine; Nursing
2,024
40,093,386
"Good, Better, How" Educational Intervention: Potential Benefits of Utilizing Feedback in General Surgery; Sequential Mixed-Methods Study of an Educational Intervention.
Advances in medical education and practice
Adv Med Educ Pract
16
null
10.2147/AMEP.S487038
eng
2,025
null
null
2,025
3
12
[BACKGROUND] Feedback is acknowledged as a necessity for effective learning and performance improvement. However, it has been shown to have variable effects on subsequent performance. This study introduces the "Good, Better, How" (GBH) framework for providing and receiving effective feedback in surgical training. [METH...
GME; feedback; medical education; surgery
0.548
47
Education
Social Sciences
2,024
40,093,319
Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice.
Frontiers in pharmacology
Front Pharmacol
16
null
10.3389/fphar.2025.1545050
eng
2,025
null
null
2,025
2
28
[INTRODUCTION] Atherosclerosis remains a major risk factor for vascular dysfunction and cardiovascular (CV) disease. Pharmacological enhancement of endothelial Ca[2+]-activated K[+] channel activity (i.e., KCa2.3 and KCa3.1) opposes vascular dysfunction associated with ageing and type 2 diabetes (T2D) in ex vivo and in...
ApoE knockout mouse; KCa channel activator; aorta; atherosclerosis; endothelial dysfunction
1.22
175
Pharmacology; Pharmacology
Medicine; Pharmacology, Toxicology and Pharmaceutics
2,024
40,093,232
Highly Sensitive Assays for detection of headache inducing neuropeptides, Pituitary adenylate cyclase-activating polypeptide (PACAP) and Calcitonin gene-related peptide (CGRP).
medRxiv : the preprint server for health sciences
medRxiv
null
null
10.1101/2025.03.04.25323177
eng
2,025
3
6
2,025
3
6
[BACKGROUND] Migraine is one of the most disabling diseases that continues to pose a significant societal burden. Although there are now treatment options for people with migraine, it remains challenging to identify them as clinical features are diverse and complex, and there are no validated diagnostic or treatment pr...
null
null
null
null
null
null
40,093,011
Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers.
Frontiers in immunology
Front Immunol
16
null
10.3389/fimmu.2025.1518208
eng
2,025
null
null
2,025
2
26
[INTRODUCTION] T Cell autoantibodies, TIgG and TIgM, as well as the T Cell-bound complement protein fragment C4d (TC4d) are novel diagnostic biomarkers that have demonstrated high specificity and sensitivity for SLE. The present study aims to characterize the clinical performance characteristics of the emergent T Cell ...
SLE biomarkers; T cell biology; complement activation in SLE; diagnostic biomarkers; lymphocyte autoantibodies
1.941
259
Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,024
40,092,919
Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway, as determined by network pharmacology.
World journal of gastrointestinal oncology
World J Gastrointest Oncol
17
3
10.4251/wjgo.v17.i3.101174
eng
2,025
3
15
null
null
null
[BACKGROUND] Hepatocellular carcinoma (HCC) is a malignant disease with high incidence and mortality worldwide. This study focuses on the TP53 target protein to investigate the potential therapeutic effect of tetrahydrocurcumin (THC) on HCC and its mechanism of action. The research hypothesis is that THC can inhibit th...
Hepatocellular carcinoma cells; Molecular docking; Network pharmacology; TP53; Tetrahydrocurcumin
null
null
null
null
null
40,092,914
Anticipated effects of an unconditional cash transfer program: A qualitative community-engaged planning study.
Preventive medicine reports
Prev Med Rep
51
null
10.1016/j.pmedr.2025.103014
eng
2,025
3
null
2,025
2
20
[INTRODUCTION] This community-engaged study explored the perspectives of residents in Oakland County, Michigan, who were experiencing poverty to understand how a proposed short-term unconditional cash transfer program may or may not influence their health and well-being. [METHODS] Community partners recruited low-incom...
Community engaged; Guaranteed income; Social risk factors; Unconditional cash transfer
1.008
60
Public Health, Environmental and Occupational Health; Health Informatics
Medicine
2,024
40,092,680
Inconclusive effects between executive functions and symptoms of psychiatric disorders in random-intercept cross-lagged panel models: a simulated reanalysis and comment on Halse et al. (2022).
Frontiers in psychology
Front Psychol
16
null
10.3389/fpsyg.2025.1500200
eng
2,025
null
null
2,025
2
28
[BACKGROUND] In a recent study of Norwegian children (N = 874), Halse et al. used random-intercept cross-lagged panel models (RI-CLPM) and concluded that their findings supported the assumption that deficiencies in executive functions and psychopathology are both a cause and a consequence of the other. However, it is k...
executive deficits; random-intercept cross-lagged panel models; reanalyses; spurious effects; symptoms of psychopathology; triangulation
0.872
212
Psychology
Psychology
2,024
40,092,052
Elevated Triglyceride-Glucose Index as a Risk Stratification Marker for Diabetic Retinopathy in Type 2 Diabetes Mellitus: The Influence of Glycemic Control.
Diabetes, metabolic syndrome and obesity : targets and therapy
Diabetes Metab Syndr Obes
18
null
10.2147/DMSO.S503672
eng
2,025
null
null
2,025
3
11
[BACKGROUND] Diabetic retinopathy (DR) is a common microvascular complication observed in people with type 2 diabetes mellitus (T2DM). The triglyceride-glucose (TyG) index, an indicator of insulin resistance, has an uncertain role in glycemic management in T2DM patients at risk for DR. This study aimed to evaluate the ...
diabetes mellitus; diabetes retinopathy; glycated hemoglobin A1c; glycemic control; insulin resistance; triglyceride-glucose index
0.827
71
Internal Medicine; Pharmacology
Medicine; Pharmacology, Toxicology and Pharmaceutics
2,024
40,091,984
Exploring the Therapeutic Potential of Three Cucurbit Plants Involving In Vivo Diabetes Screening.
Cureus
Cureus
17
2
10.7759/cureus.78861
eng
2,025
2
null
2,025
2
11
[BACKGROUND] Trichosanthes cucumerina L. (TC), Momordica charantia var. muricata (Willd.) Chakrav. (MCM), and Luffa acutangula (L) Roxb. (LA) are common vegetables widely used in traditional and folk systems of medicine for various ailments including diabetes. [METHODOLOGY] This work evaluated the antidiabetic potentia...
diabetes mellitus; luffa acutangula; momordica charantia var. muricata; traditional medicine; trichosanthes cucumerina
null
null
null
null
null
40,091,608
Completed suicide in patients with skin disease: A systematic review and meta-analysis.
Journal of the European Academy of Dermatology and Venereology : JEADV
J Eur Acad Dermatol Venereol
null
null
10.1111/jdv.20609
eng
2,025
3
17
2,025
3
17
[BACKGROUND] Several skin diseases have been associated with suicidality. However, the term 'suicidality' encompasses ideation, which weakens the conclusions. In contrast, the much stronger endpoint of completed suicide and skin disease remains ambiguous. [OBJECTIVE] To determine the risk of completed suicide in adult ...
null
2.154
144
Dermatology; Infectious Diseases
Medicine
2,024
40,091,504
The value of routine histopathological examination after haemorrhoidectomy in patients at low and high risk of anal squamous intraepithelial lesions and cancer.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Colorectal Dis
27
3
10.1111/codi.70056
eng
2,025
3
null
null
null
null
[AIM] Routine histopathological evaluation of haemorrhoidectomy specimens is not ubiquitous amongst surgeons as its utility is debatable. This is the first study to assess the detection rate of anal squamous intraepithelial lesions (aSIL) and anal squamous cell carcinoma (aSCC) in low- and high-risk patients. [METHOD] ...
anal cancer; anal dysplasia; anal intraepithelial neoplasia; anal squamous cell carcinoma; anal squamous intraepithelial lesions; haemorrhoidectomy; histopathology; routine histopathology
1.005
110
Gastroenterology
Medicine
2,024
40,091,186
Predictive model for optimizing prehospital transfusions in an urban EMS system.
Transfusion
Transfusion
65 Suppl 1
Suppl 1
10.1111/trf.18209
eng
2,025
5
null
2,025
3
16
[BACKGROUND] Prehospital transfusions might provide a survival benefit for injured patients. Because blood products are a scarce resource, their optimal deployment requires careful consideration. A computer model was built to explore different deployment scenarios for two blood-carrying ambulances (mobile blood banks, ...
ambulance; emergency; injury; model; prehospital; simulation; transfusion; trauma
0.706
153
Hematology; Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,024
40,091,007
Food production diversity based on food groups is associated with minimum dietary diversity and dietary diversity among lactating mothers residing in subsistence farming households in rural Kyankwanzi district, Uganda.
BMC public health
BMC Public Health
25
1
10.1186/s12889-025-22243-z
eng
2,025
3
17
2,025
3
17
[BACKGROUND] Consuming a variety of food groups is a proxy indicator of micronutrient adequacy among women of reproductive age (WRA). This study examined the association between minimum food group production diversity (MFGPD) and minimum dietary diversity for women (MDD-W); and the correlation between food group produc...
Food groups; Food production diversity; Lactating mothers; Minimum dietary diversity; Women's dietary diversity
1.359
211
Public Health, Environmental and Occupational Health
Medicine
2,024
40,090,778
Indication model for laparoscopic repeat liver resection in the era of artificial intelligence: machine learning prediction of surgical indication.
HPB : the official journal of the International Hepato Pancreato Biliary Association
HPB (Oxford)
27
6
10.1016/j.hpb.2025.02.016
eng
2,025
6
null
2,025
3
4
[BACKGROUND] Laparoscopic repeat liver resection (LRLR) is still a challenging technique and requires a careful selection of indications. However, the current difficulty scoring system is not suitable for selecting indications. The purpose of this study is to develop the indication model for LRLR using machine learning...
null
1.119
98
Gastroenterology; Hepatology
Medicine
2,024
40,090,564
Early Manifestations of Neurodevelopmental Copy Number Variants in Children: A Population-Based Investigation.
Biological psychiatry
Biol Psychiatry
null
null
10.1016/j.biopsych.2025.03.004
eng
2,025
3
14
2,025
3
14
[BACKGROUND] There is clinical interest in recognizing copy number variants (CNVs) in children because many have immediate and long-term health implications. Neurodevelopmental (ND) CNVs are associated with intellectual disability, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD), con...
ADHD; ALSPAC; ASD; Copy number variants; Millennium Cohort Study; Neurodevelopmental conditions
4.684
367
Biological Psychiatry
Neuroscience
2,024
40,090,557
OTUB1 promotes glioma progression by stabilizing TRAF4.
Cellular signalling
Cell Signal
131
null
10.1016/j.cellsig.2025.111704
eng
2,025
7
null
2,025
3
14
[BACKGROUND] Glioma is a highly heterogeneous brain tumor with poor prognosis. This study aims to investigate the functional role of OTUB1 in glioma and its impact on TRAF4 stability, seeking potential therapeutic targets. [METHODS] We mined single-cell sequencing data from 12 glioma patients to analyze the heterogenei...
Glioma; OTUB1; Single-cell sequencing; Ubiquitination
1.239
172
Cell Biology
Biochemistry, Genetics and Molecular Biology
2,024
40,090,530
SRSF10 regulates isoform expression of transcripts associated with proliferative diabetes retinopathy in ARPE-19 cells based on long-read RNA and immunoprecipitation sequencing.
Gene
Gene
957
null
10.1016/j.gene.2025.149412
eng
2,025
7
15
2,025
3
14
[BACKGROUND] Following injury and disruption of the retinal barrier, retinal pigment epithelium can differentiate into a fibroblastic phenotype, leading to proliferation and migration, thereby resulting in pathological conditions such as proliferative vitreoretinopathy and diabetic retinopathy. Previous studies have de...
ARPE-19; Alternative splicing; Long-read sequencing; Proliferative diabetic retinopathy; Proliferative vitreoretinopathy; iRIP-seq
0.682
200
Medicine; Genetics
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,090,477
Vulnerability and psychosocial impacts of extreme weather events among young people in Australia.
Environmental research
Environ Res
275
null
10.1016/j.envres.2025.121385
eng
2,025
6
15
2,025
3
14
[AIMS] There is growing awareness of the negative impact that extreme weather events (also known as climate disasters) have on psychological and social wellbeing. Adolescents are particularly vulnerable to the psychosocial impacts of these events, but research specific to this population is scant. This study examined t...
null
1.822
196
Biochemistry; Environmental Science; Public Health, Environmental and Occupational Health
Biochemistry, Genetics and Molecular Biology; Environmental Science; Medicine
2,024
40,090,461
Mortality and Stroke after Routine Left Atrial Appendage Occlusion in Patients Undergoing Isolated Mitral Repair without Atrial Fibrillation in the United States.
The Journal of thoracic and cardiovascular surgery
J Thorac Cardiovasc Surg
null
null
10.1016/j.jtcvs.2025.03.006
eng
2,025
3
14
2,025
3
14
[BACKGROUND] The role of prophylactic concomitant left atrial appendage closure during mitral repair in patients without atrial fibrillation (AF) is not defined. [OBJECTIVES] The objective was to compare long-term outcomes of patients who had left atrial appendage closure during mitral repair with those who did not in ...
Mitral valve; atrial fibrillation; left atrial appendage occlusion
1.932
225
Cardiology and Cardiovascular Medicine; Pulmonary and Respiratory Medicine; Surgery
Medicine
2,024
40,090,432
A novel data-driven approach for Personas validation in healthcare using self-supervised machine learning.
Journal of biomedical informatics
J Biomed Inform
165
null
10.1016/j.jbi.2025.104815
eng
2,025
5
null
2,025
3
14
[OBJECTIVE] Persona validation is a challenging task, often relying on costly external validation methods. The aim of this study was the development of a novel method for Personas validation based on data already available during their creation. [METHODS] A novel approach based on self-supervised machine learning (SSML...
Clustering; Personalized care; Personas; Self-supervised machine learning; Validation
1.257
137
Computer Science Applications; Health Informatics
Computer Science; Medicine
2,024
40,090,407
Functional Outcome of Adult Traumatic Brain Injury Patients Treated by Decompressive Craniectomy in an Ethiopian Trauma Center.
World neurosurgery
World Neurosurg
197
null
10.1016/j.wneu.2025.123899
eng
2,025
5
null
2,025
3
14
[OBJECTIVE] To describe the long-term functional outcome of traumatic brain injury (TBI) patients treated by decompressive craniectomy (DC). [METHODS] Data was collected on decompressive craniectomy performed on TBI patients admitted between May 1, 2018, and May 1, 2021, using a multi-center, cross-sectional study desi...
Decompressive craniectomy; Factors affecting functional outcome; Functional outcome
0.709
123
Neurology; Surgery
Medicine
2,024
40,090,317
Pharmacokinetic Properties of Dapagliflozin in Patients with Stage 4 Chronic Kidney Disease.
American journal of nephrology
Am J Nephrol
null
null
10.1159/000544936
eng
2,025
3
14
2,025
3
14
[INTRODUCTION] The pharmacokinetic data on dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, are limited in patients with severe renal impairment. We aimed to evaluate the pharmacokinetic properties and safety of dapagliflozin in patients with chronic kidney disease (CKD) stage 4. [METHODS] This was a single-c...
Chronic kidney disease; Dapagliflozin; Pharmacokinetic properties
1.4
107
Nephrology
Medicine
2,024
40,090,311
Subjective Sleep Quality and Its Subcomponents Among Homeless Individuals in São Paulo.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Braz J Psychiatry
null
null
10.47626/1516-4446-2024-4078
eng
2,025
1
16
2,025
1
16
[OBJECTIVE] Sleep quality is essential for health, with sleep deprivation linked to physical and mental issues. Homeless populations face additional sleep challenges, yet this topic remains underexplored. This study assessed sleep quality among homeless individuals in São Paulo, Brazil, considering demographics and sub...
Ill-housed persons; homeless; sleep quality; substance use
1.065
72
Psychiatry and Mental Health
Medicine
2,024
40,090,171
Brucellosis and associated risk factors, spatial distribution and cluster analysis: Case study in Khorasan Razavi Province, Iran.
Journal of infection and public health
J Infect Public Health
18
6
10.1016/j.jiph.2025.102747
eng
2,025
6
null
2,025
3
11
[BACKGROUND] Brucellosis is a common zoonotic disease in Iran. This study aimed to investigate the epidemiological characteristics of human brucellosis and its affecting factors in Khorasan Razavi province, an endemic region in north-eastern Iran. [METHODS] In this descriptive-analytical study, the data of 15,334 bruce...
Brucellosis; Cluster Analysis; GIS; Incidence; Khorasan Razavi
1.007
73
Infectious Diseases; Medicine; Public Health, Environmental and Occupational Health
Medicine
2,024
40,089,800
Indirect treatment comparison of oral sebetralstat and intravenous recombinant human C1 esterase inhibitor for on-demand treatment of hereditary angioedema attacks.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Allergy Asthma Clin Immunol
21
1
10.1186/s13223-025-00955-6
eng
2,025
3
15
2,025
3
15
[BACKGROUND] The goal of on-demand treatment for hereditary angioedema attacks is to halt attack progression to minimize morbidity and mortality. Four on-demand treatments have been approved thus far (ecallantide, icatibant, recombinant human C1 esterase inhibitor [rhC1INH], and plasma-derived C1INH). Results from the ...
Hereditary angioedema; Indirect treatment comparison; Matching-adjusted indirect comparison; Sebetralstat; rhC1INH
0.779
56
Pulmonary and Respiratory Medicine; Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,024
40,089,722
Comparative analysis of croup severity and treatment in pediatric patient: a study of COVID-19 positive vs. negative cases during peak Omicron.
BMC pediatrics
BMC Pediatr
25
1
10.1186/s12887-025-05536-5
eng
2,025
3
15
2,025
3
15
[BACKGROUND] The Omicron variant of SARS-CoV-2 has been associated with unique clinical presentations in children, including croup-like symptoms such as barking cough, hoarseness, and respiratory distress. This study aimed to compare the clinical, laboratory, and treatment characteristics of hospitalized pediatric pati...
COVID-19; Children; Croup; Hospitalization; Omicron variant; Pediatric respiratory illness
0.734
106
Pediatrics, Perinatology and Child Health
Medicine
2,024
40,089,300
Indicators of Functional Disability by Receipt of Disability Benefits Among Individuals With Systemic Lupus Erythematosus.
The Journal of rheumatology
J Rheumatol
52
5
10.3899/jrheum.2024-0961
eng
2,025
5
1
2,025
5
1
[OBJECTIVE] We estimated the prevalence of potential functional disability among those with systemic lupus erythematosus (SLE), by receipt of disability benefits. [METHODS] Participants (N = 443, mean age 46.2 years, 91.7% women, 82.6% Black) were recruited from a population-based SLE cohort. Indicators of potential di...
activities of daily living; cognitive dysfunction; disability evaluation; disability studies; physical functional performance; systemic lupus erythematosus
1.135
201
Rheumatology; Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,024
40,089,298
Correlation Between Interferon Response Gene Score and Disease Activity in Juvenile Dermatomyositis.
The Journal of rheumatology
J Rheumatol
52
6
10.3899/jrheum.2024-0806
eng
2,025
6
1
2,025
6
1
[OBJECTIVE] Type 1 interferons (IFNs) have been identified as potentially important measures of disease activity in juvenile dermatomyositis (JDM). An IFN response gene (IRG) score has been defined using NanoString technology and appears to correlate with disease activity in cross-sectional samples of patients with JDM...
alpha interferon; beta interferon; juvenile dermatomyositis
1.135
201
Rheumatology; Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,024
40,088,690
Assessing the efficacy and safety of calcium gluconate soaking as a treatment modality for hydrofluoric acid burns.
Burns : journal of the International Society for Burn Injuries
Burns
51
4
10.1016/j.burns.2025.107422
eng
2,025
5
null
2,025
2
8
[INTRODUCTION] Hydrofluoric acid is extremely toxic and can corrode tissues while reacting with calcium and magnesium, leading to severe tissue damage. The antidote, calcium gluconate, is effective for treating mild to moderate burns. However, our hospital lacks registered calcium gluconate gel, making treatment challe...
Calcium gluconate treatment; Electrolyte imbalance; Emergency medicine; Hydrofluoric acid burns; Treatment efficacy
0.764
123
Emergency Medicine; Surgery; Critical Care and Intensive Care Medicine; Medicine
Medicine
2,024
40,088,372
The efficacy, safety, and persistence of vedolizumab versus adalimumab in patients with inflammatory bowel disease: a systematic review and meta-analysis.
Inflammopharmacology
Inflammopharmacology
33
4
10.1007/s10787-025-01710-4
eng
2,025
4
null
2,025
3
15
[PURPOSE] This systematic review and meta-analysis compared the efficacy, safety, and treatment persistence of vedolizumab and adalimumab in patients with inflammatory bowel disease (IBD). [METHODS] Through a comprehensive search of three databases up to September 2024, we calculated pooled effect estimates for binary ...
Adalimumab; Efficacy; Inflammatory bowel disease; Meta-analysis; Vedolizumab
1.269
74
Pharmacology; Pharmacology; Immunology
Immunology and Microbiology; Medicine; Pharmacology, Toxicology and Pharmaceutics
2,024
40,088,306
Effect of controlled hyperventilation on post-laparoscopic cholecystectomy shoulder pain: a prospective randomized controlled trial.
Langenbeck's archives of surgery
Langenbecks Arch Surg
410
1
10.1007/s00423-025-03666-z
eng
2,025
3
15
2,025
3
15
[OBJECTIVE] This study investigated whether intraoperative controlled hyperventilation could reduce the incidence and severity of post-laparoscopic shoulder pain. [METHODS] In this prospective, randomized, double-blind controlled trial, 150 patients undergoing elective laparoscopic cholecystectomy were randomly assigne...
Controlled hyperventilation; Laparoscopic cholecystectomy; Pneumoperitoneum; Postoperative pain management; Shoulder pain
0.694
94
Surgery
Medicine
2,024
40,088,250
Improving Postoperative Handoff Communication in the Neuroscience Intensive Care Unit: A Quality Improvement Project.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses
J Perianesth Nurs
null
null
10.1016/j.jopan.2024.11.014
eng
2,025
3
13
2,025
3
13
[PURPOSE] This quality improvement project aimed to improve postoperative handoff communication between anesthesia providers and neuroscience intensive care unit nurses by developing and implementing a standardized postoperative handoff checklist for the neurosurgical patient population. [DESIGN] A quality improvement ...
checklist; intensive care unit (ICU); neurosciences; patient safety; postoperative handoff; quality improvement (QI)
0.487
41
Medical and Surgical Nursing
Nursing
2,024
40,088,136
Intraoperative Blood Loss Predicts Local Recurrence After Curative Resection for Stage I-III Colorectal Cancer.
World journal of surgery
World J Surg
49
5
10.1002/wjs.12533
eng
2,025
5
null
2,025
3
15
[BACKGROUND] To identify the predictors of local recurrence and distant metastasis after radical surgery for stage I-III colorectal cancer. [MATERIALS AND METHODS] Patient and tumor characteristics, clinicopathological stages, perioperative factors, and postoperative outcomes, including local and distant recurrence, of...
anastomotic leakage; colorectal cancer; intraoperative blood loss; recurrence pattern
0.771
176
Surgery
Medicine
2,024
40,088,128
The Fall Out of the 2017 European Medical Device Regulation for Tracheal Occlusion.
Prenatal diagnosis
Prenat Diagn
45
4
10.1002/pd.6763
eng
2,025
4
null
2,025
3
15
[OBJECTIVE] The use of the Balt Goldbal-balloon and Baltacci-catheter in Fetoscopic Endoluminal Tracheal Occlusion is affected by the 2017-European Medical Device Regulation, which necessitates recertification even for devices long considered safe. This regulation has led the manufacturer to stop distributing these dev...
null
0.932
110
Obstetrics and Gynecology; Genetics
Medicine
2,024
40,087,775
Diversity and functional features of the root-associated bacteriome are dependent on grapevine susceptibility to Plasmopara viticola.
Environmental microbiome
Environ Microbiome
20
1
10.1186/s40793-025-00690-w
eng
2,025
3
14
2,025
3
14
[BACKGROUND] Plant health depends on beneficial interactions between the roots and their microbiomes. Despite recent progress on the role of the grapevine microbiome, the taxonomic identity and functional traits of microbial taxa specific to healthy or Plasmopara viticola-diseased plants, as well as to the susceptible ...
Plasmopara viticola; Cultivar; Disease resistance; Functional features; Grapevine; Microbiome; Root-associated microbiota
null
null
null
null
null
40,087,716
CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1.
Hereditas
Hereditas
162
1
10.1186/s41065-025-00406-7
eng
2,025
3
14
2,025
3
14
[BACKGROUND] Nasopharyngeal carcinoma (NPC) is a malignant head and neck cancer with high mortality and dismal prognosis. Emerging research have disclosed that circRNAs are crucial gene expression regulators engaged in tumor advancement. This work aspired to identify novel oncogenic circRNA driving NPC progression. [ME...
BMI1; CircCENPM; Metastasis; NPC; miR-362-3p
0.596
57
Medicine; Genetics
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,087,589
Effectiveness of UK-based support interventions and services aimed at adults who have experienced or used domestic and sexual violence and abuse: a systematic review and meta-analysis.
BMC public health
BMC Public Health
25
1
10.1186/s12889-025-21891-5
eng
2,025
3
14
2,025
3
14
[BACKGROUND] Domestic and sexual violence and abuse (DSVA) is prevalent and harmful. There are a range of support services and interventions available to those affected by it, but evidence of their effectiveness is uncertain. We synthesised evidence on the effectiveness of UK-based interventions and services for DSVA. ...
Domestic abuse; Interventions; Safety; Services; Sexual violence; Systematic review; Wellbeing
1.359
211
Public Health, Environmental and Occupational Health
Medicine
2,024
40,087,553
Single specimen genome assembly of Culicoides stellifer shows evidence of a non-retroviral endogenous viral element.
BMC genomics
BMC Genomics
26
1
10.1186/s12864-025-11449-5
eng
2,025
3
14
2,025
3
14
[BACKGROUND] Advancing our knowledge of vector species genomes is a key step in our battle against the spread of diseases. Biting midges of the genus Culicoides are vectors of arboviruses that significantly affect livestock worldwide. Culicoides stellifer is a suspected vector with a wide range distribution in North Am...
Culicoides; Arboviruses; Genome assembly; Vector; Vesicular stomatitis virus
1.003
208
Biotechnology; Genetics
Biochemistry, Genetics and Molecular Biology
2,024
40,087,552
LXRα agonists ameliorates acute rejection after liver transplantation via ABCA1/MAPK and PI3K/AKT/mTOR signaling axis in macrophages.
Molecular medicine (Cambridge, Mass.)
Mol Med
31
1
10.1186/s10020-025-01153-1
eng
2,025
3
14
2,025
3
14
[INTRODUCTION] Liver X receptor α (LXRα) plays an important role in inflammatory immune response induced by hepatic ischemia-reperfusion injury (IRI) and acute rejection (AR). Macrophage M1-polarization play an important role in the occurrence and development of AR. Although the activation of LXR has anti-inflammatory ...
Acute rejection; Inflammation; Liver transplantation; M1 polarization; Macrophage
1.752
136
Genetics; Genetics; Molecular Biology; Molecular Medicine
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,087,057
Predicting Severe Radiation Pneumonitis in Patients With Locally-Advanced Non-Small-Cell Lung Cancer After Thoracic Radiotherapy: Development and Validation of a Nomogram Based on the Clinical, Hematological, and Dose-Volume Histogram Parameters.
Clinical lung cancer
Clin Lung Cancer
26
5
10.1016/j.cllc.2025.02.009
eng
2,025
7
null
2,025
2
21
[PURPOSE] This study aimed to investigate the risk factors for severe radiation pneumonitis (RP) after thoracic radiotherapy (RT) in patients with locally advanced non-small cell lung cancer (NSCLC), develop a prediction model to identify high-risk groups, and investigate the impact of severe RP on overall survival (OS...
Dosimetric parameter; Peripheral blood biomarkers; Radiation pneumonia
1.515
78
Oncology; Pulmonary and Respiratory Medicine; Cancer Research
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,086,912
Effectiveness of enhanced group cognitive behaviour therapy for older adults (CBT-OA) with depression and anxiety: A replication study.
International psychogeriatrics
Int Psychogeriatr
37
2
10.1016/j.inpsyc.2024.100013
eng
2,025
3
null
2,024
12
4
[OBJECTIVES] Enhanced cognitive behavioural therapy for older adults (CBT-OA) modifies standard CBT to better address the needs of older adults, considering age-related impacts on learning. This study evaluated the effectiveness of Cassidy's manualized CBT-OA protocol (Cassidy, 2016a, 2016b) for late-life depression or...
null
1.37
126
Clinical Psychology; Geriatrics and Gerontology; Gerontology; Psychiatry and Mental Health
Medicine; Nursing; Psychology
2,024
40,086,731
Gender imbalance in critical care medicine journals.
Anaesthesia, critical care pain medicine
Anaesth Crit Care Pain Med
44
3
10.1016/j.accpm.2025.101504
eng
2,025
5
null
2,025
3
12
[INTRODUCTION] The present study aimed at assessing gender balance in the Editorial roles of Critical Care Medicine (CCM) journals. [METHODS] A cross-sectional survey was performed for assessing the gender distribution in Editorial Board (EB) roles of journals indexed under Clarivate Journal Citation Reports and Scimag...
Critical care medicine journals; Diversity; Editorial board; Gender gap; Inclusion.
null
null
null
null
null
40,086,644
Total Knee Arthroplasty Design Without Cruciates to Achieve Anatomic Femoral-Tibial Motion and Laxity.
The Journal of arthroplasty
J Arthroplasty
40
7S1
10.1016/j.arth.2025.03.014
eng
2,025
7
null
2,025
3
12
[BACKGROUND] A frequently stated goal of an artificial knee arthroplasties is to achieve normal kinematics. However, this is not easily defined based on variations in motions previously measured for a range of activities. For activities such as crouching up and down, a fan pattern has been measured, where the lateral f...
knee laxity; non-cruciate total knee; total knee conformity; total knee design; total knee kinematics
1.951
171
Orthopedics and Sports Medicine
Medicine
2,024
40,086,374
Comparative perioperative narcotic use in tlif patients: Spinal versus general anesthesia in a retrospective cohort study of 180 cases in hospital and ambulatory settings.
Clinical neurology and neurosurgery
Clin Neurol Neurosurg
251
null
10.1016/j.clineuro.2025.108840
eng
2,025
4
null
2,025
3
12
[OBJECTIVES] To implement an integrated anesthesia and surgery protocol of improved postoperative pain control to facilitate transitioning of minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) from a hospital to an ambulatory surgery center setting by lowering postoperative (in-facility) narcotic consu...
Awake minimally invasive surgery; Hospital stay; Morphine milligram equivalents (MME); Perioperative narcotic utilization; Post-operative length of stay (LOS); Post-operative recovery metrics; Spinal anesthesia vs. General anesthesia; Transforaminal lumbar interbody fusion (TLIF)
0.594
89
Medicine; Surgery; Neurology
Medicine
2,024
40,086,048
Efficacy and safety of entrectinib in children with extracranial solid or central nervous system (CNS) tumours harbouring NTRK or ROS1 fusions.
European journal of cancer (Oxford, England : 1990)
Eur J Cancer
220
null
10.1016/j.ejca.2025.115308
eng
2,025
5
2
2,025
2
22
[BACKGROUND] Entrectinib, a central nervous system (CNS)-penetrant TRK/ROS1 inhibitor, has demonstrated clinical activity in children with NTRK1/2/3 or ROS1 fusion-positive extracranial solid and CNS tumours. We present integrated data of entrectinib in children with NTRK or ROS1 fusion-positive tumours from the STARTR...
CNS tumours; Entrectinib; NTRK fusions; Paediatric tumours; ROS1 fusions; ROS1 inhibitor; STARTRK-2; STARTRK-NG; TAPISTRY; TRK inhibitor
2.691
256
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,085,784
Predicting the risk grades of thymic epithelial tumours using T1 mapping and diffusion-weighted MRI.
The British journal of radiology
Br J Radiol
98
1170
10.1093/bjr/tqaf060
eng
2,025
6
1
null
null
null
[OBJECTIVE] To explore the value of native T1 and apparent diffusion coefficients (ADCs) for predicting subtypes and stages of thymic epithelial tumours (TETs). [METHODS] Sixty-seven patients with TETs confirmed by pathological analysis were retrospectively enrolled. The mean native T1 (T1mean), global native T1 (ADCto...
Masoaka-Koga staging; T1 mapping; WHO histological classification; apparent diffusion coefficient; diffusion-weighted imaging; thymic epithelial tumours
0.875
128
Radiology, Nuclear Medicine and Imaging; Medicine
Medicine
2,024
40,085,260
Relationship of corneal percent tissue altered with visual outcome in small incision lenticule extraction surgery.
International ophthalmology
Int Ophthalmol
45
1
10.1007/s10792-025-03483-9
eng
2,025
3
14
2,025
3
14
[BACKGROUND] We observed the effect of different modified percentage of tissue alteration (mPTA) on corneal higher-order aberrations in small incision lenticule extraction (SMILE), and explored safe threshold values of mPTA for SMILE surgery. [METHODS] 148 patients (270 eyes) was retrospectively analyzed and grouped in...
Corneal higher order aberrations; Modified percent tissue altered; Small-incision lenticule extraction; Visual quality
0.642
57
Ophthalmology
Medicine
2,024
40,085,183
The Pandora's Box of Bariatric Surgery: Unveiling the Association with Kidney Stone Risk-A Cross-Sectional Study.
Obesity surgery
Obes Surg
35
4
10.1007/s11695-025-07795-8
eng
2,025
4
null
2,025
3
14
[BACKGROUND] Metabolic and bariatric surgery is an effective intervention for severe obesity, known for improving comorbidities such as type 2 diabetes, hypertension, and hyperlipidemia. However, its association with kidney stone formation remains uncertain. This study investigates the relationship between bariatric su...
Bariatric surgery; Kidney stones; NHANES, obesity; Nephrolithiasis; Weight loss
1.148
164
Endocrinology, Diabetes and Metabolism; Nutrition and Dietetics; Surgery
Medicine; Nursing
2,024
40,085,160
Deciphering aptamer-protein interactions for bovine sperm sorting through in silico and in vitro studies.
Molecular biology reports
Mol Biol Rep
52
1
10.1007/s11033-025-10402-9
eng
2,025
3
12
2,025
3
12
[BACKGROUND] In recent years, aptamers have emerged as versatile molecular tools with promising applications in various fields, including diagnostics and therapeutics. In livestock reproduction, their application holds promise for improving the sorting and identification of X and Y chromosome-bearing sperm cells, which...
In silico analysis; Aptamers; Bovine; Cell-SELEX; Interaction analysis; Semen sexing
0.71
96
Genetics; Medicine; Molecular Biology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
40,085,140
Measuring Mental Health in 2 Brazilian University Centers: Protocol for a Cohort Survey.
JMIR research protocols
JMIR Res Protoc
14
null
10.2196/63636
eng
2,025
3
14
2,025
3
14
[BACKGROUND] Global concern for the mental well-being of university students is on the rise. Recent studies estimate that around 30% of students experience mental health disorders, and nearly 80% of these individuals do not receive adequate treatment. Brazil, home to around eight million university students, lacks suff...
college students; longitudinal survey; mental health screening; study design; university students
0.527
45
Medicine
Medicine
2,024
40,084,984
The impact of refractive error correction on health-related quality of life in nursing home residents in Armenia.
Disability and rehabilitation
Disabil Rehabil
null
null
10.1080/09638288.2025.2477831
eng
2,025
3
14
2,025
3
14
[PURPOSE] This study assessed the impact of refractive error (RE) correction on health-related quality of life (HRQoL) among nursing home residents. [MATERIALS/METHODS] This quasi-experimental study with comparison group enrolled 249 participants for baseline and follow-up assessments in August 2021 and January 2022, r...
Refractive errors; compliance; health-related quality of life; nursing home; visual impairment
0.972
140
Rehabilitation
Medicine
2,024
40,084,601
Cognitive disengagement syndrome and depressive symptoms in early adolescents: Examining the moderating role of a negative interpretation bias.
Journal of child psychology and psychiatry, and allied disciplines
J Child Psychol Psychiatry
66
9
10.1111/jcpp.14156
eng
2,025
9
null
2,025
3
14
[BACKGROUND] Despite previous research demonstrating an independent association between cognitive disengagement syndrome (CDS; previously termed sluggish cognitive tempo) and depressive symptoms, studies have yet to examine what factors may moderate this link. A negative interpretation bias (i.e., maladaptive informati...
Cognitive disengagement syndrome; depression; informant discrepancies; negative interpretation bias; sluggish cognitive tempo
2.988
252
Developmental and Educational Psychology; Pediatrics, Perinatology and Child Health; Psychiatry and Mental Health
Medicine; Psychology
2,024
40,084,500
Cordycepin's therapeutic potential: in vivo transport, transbilayer diffusion and anti-aging effects.
Journal of the science of food and agriculture
J Sci Food Agric
105
9
10.1002/jsfa.14220
eng
2,025
7
null
2,025
3
14
[BACKGROUND] Cordycepin (3'-deoxyadenosine) is a bioactive compound known for its numerous beneficial properties, including antioxidant, anti-aging and antitumor effects. Despite its promising therapeutic potential, the in vivo transport mechanisms of cordycepin remain inadequately understood. Previous studies have hig...
biological membranes; cordycepin; transporter protein
null
null
null
null
null
40,083,799
The impact of a school-based physical activity program on children's movement behaviors, aerobic fitness and motor competence: a follow up study.
Frontiers in sports and active living
Front Sports Act Living
7
null
10.3389/fspor.2025.1541862
eng
2,025
null
null
2,025
2
27
[OBJECTIVE] This study evaluated the one-year impact of a 12-week school-based physical activity (PA) intervention, which added one extra hour of structured PA per week, on children's movement behaviors, aerobic fitness, and motor competence (MC). [METHODS] A longitudinal comparison between an experimental group (EG) a...
childhood; exercise; health; physical activity program; sedentarism
0.864
28
Anthropology; Physical Therapy, Sports Therapy and Rehabilitation; Orthopedics and Sports Medicine; Physiology; Public Health, Environmental and Occupational Health; Tourism, Leisure and Hospitality Management
Biochemistry, Genetics and Molecular Biology; Business, Management and Accounting; Health Professions; Medicine; Social Sciences
2,024
40,083,537
Maternal-Fetal Listeriosis in China: Clinical and Genomic Characteristics From an ST8 Listeria monocytogenes Case.
Infection and drug resistance
Infect Drug Resist
18
null
10.2147/IDR.S508470
eng
2,025
null
null
2,025
3
8
[BACKGROUND] Listeriosis, a severe foodborne infection caused by Listeria monocytogenes, poses significant risks during pregnancy, including maternal-neonatal transmission. This study describes the clinical and genomic characteristics of an sequence type 8 (ST8) L. monocytogenes strain involved in maternal-neonatal tra...
Listeria monocytogenes; ST8; antimicrobial susceptibility; whole-genome sequencing
0.793
74
Infectious Diseases; Pharmacology; Pharmacology
Medicine; Pharmacology, Toxicology and Pharmaceutics
2,024
40,083,427
Eliglustat substrate reduction therapy in children with Gaucher disease type 1.
Frontiers in pediatrics
Front Pediatr
13
null
10.3389/fped.2025.1543136
eng
2,025
null
null
2,025
2
27
[IMPORTANCE] Gaucher disease (GD) is a rare lysosomal storage disorder with limited treatment options for pediatric patients. Oral substrate reduction therapy (SRT) with eliglustat offers a potential alternative, particularly for those with barriers to enzyme replacement therapy (ERT). [OBJECTIVE] Evaluate the safety a...
Gaucher disease (GD); eliglustat; lysosomal storage disease (LSD); precision medicine; substrate reduction therapy (SRT)
0.738
83
Pediatrics, Perinatology and Child Health
Medicine
2,024
40,082,882
Research on the biomechanical characteristics of the tibiofemoral joint before and after kinematic alignment unicompartmental knee arthroplasty.
Journal of orthopaedic surgery and research
J Orthop Surg Res
20
1
10.1186/s13018-025-05659-6
eng
2,025
3
14
2,025
3
14
[BACKGROUND] Kinematic alignment (KA) unicompartmental knee arthroplasty (UKA), which has not been widely adopted in clinical practice, aims to implant a more personalized and physiologically compatible mobile-bearing UKA prosthesis for the treatment of advanced single compartment knee osteoarthritis. KA UKA is anticip...
Biomechanical testing; Cadaveric knee specimen; Kinematic alignment; Tibiofemoral joint; Unicompartmental knee arthroplasty
0.877
75
Orthopedics and Sports Medicine; Surgery
Medicine
2,024
40,082,871
Risk factors of immune-related endocrine toxicities in non-small cell lung cancer patients treated with pembrolizumab and its impact on patient outcomes: a multicenter retrospective study.
BMC pulmonary medicine
BMC Pulm Med
25
1
10.1186/s12890-025-03570-8
eng
2,025
3
13
2,025
3
13
[BACKGROUND] Pembrolizumab has been approved as a first-line treatment for non-small cell lung cancer (NSCLC) patients. However, a percentage of patients discontinue immunotherapy due to immune-related adverse events (irAE). Among these events, immune-related endocrine toxicities (E-irAE) represents the most common for...
Immune-related endocrine toxicities; Immune-related thyroid dysfunction; Immunotherapy; Non-small cell lung cancer; Pembrolizumab
0.889
85
Pulmonary and Respiratory Medicine
Medicine
2,024
40,082,775
Caregiver and care team perspectives of caregiver psychological distress and well-being during critical care hospitalization: a qualitative study.
BMC geriatrics
BMC Geriatr
25
1
10.1186/s12877-025-05769-0
eng
2,025
3
13
2,025
3
13
[BACKGROUND] Family caregiver psychological distress during an older adult's critical care hospitalization can compromise their well-being and ability to function in a supportive role for patient recovery. Understanding factors influencing family caregiver distress and well-being during this period is crucial for devel...
Critical care; Critical illness; Family caregiver; Hospitalization; Psychological distress
1.335
112
Geriatrics and Gerontology
Medicine
2,024
40,082,329
Combined Rigid-Flexible Multibody Analysis Reveals Reduced Pedicle Screw Loads in Short-Segment Fixation for Decompressed Lumbar Spine Stabilization.
Annals of biomedical engineering
Ann Biomed Eng
53
5
10.1007/s10439-025-03706-1
eng
2,025
5
null
2,025
3
13
[BACKGROUND] Spinal cord compression in patients with vertebral metastases often requires surgical decompression with spinal fixation. Recent studies reported increased implant failures due to mechanical complications, raising concerns about current clinical practices. Long-segment fixation (Lf) is commonly employed to...
Coupled modelling; Fatigue strength; Flexible body modelling; Long-segment fixation; Multibody model; Pedicle screw; Short-segment fixation; Spinal cord decompression; Spinal fixation; Spinal metastasis
0.767
163
Biomedical Engineering
Engineering
2,024
40,082,319
Vitamin D3 suppresses NLRP3 inflammasome pathway and enhances steroid sensitivity in a neutrophilic steroid hyporesponsive asthma mouse model.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Inflamm Res
74
1
10.1007/s00011-025-02009-4
eng
2,025
3
14
2,025
3
14
[OBJECTIVE] Severe steroid hyporesponsive asthma is a heterogeneous group of chronic inflammatory diseases characterized by irreversible airflow limitation, hyperresponsiveness, inflammation, and remodelling of the airways. Severe asthmatics account for more than 60% of asthma-related healthcare cost worldwide given th...
NLRP3 inflammasome; Neutrophilic airway inflammation; Severe asthma; Steroid resistance; Vitamin D3
1.388
112
Immunology; Pharmacology
Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics
2,024
40,082,252
Hydrogen sulfide attenuates oxidative stress-induced cellular senescence via the Sirt3/SOD2 signaling pathway in chronic obstructive pulmonary disease.
Chinese medical journal
Chin Med J (Engl)
null
null
10.1097/CM9.0000000000003452
eng
2,025
3
14
2,025
3
14
[BACKGROUND] Senescence significantly participates in shaping the pathobiological process underlying chronic obstructive pulmonary disease (COPD). Currently, the mechanisms underlying the anti-aging effects within COPD of hydrogen sulfide (H2S) are not fully illustrated. [METHODS] Immunohistochemistry (IHC) staining wa...
null
1.213
84
Medicine
Medicine
2,024
40,081,972
Exploring service users' and healthcare professionals' experience of digital and face-to-face Health Checks in England: a qualitative study.
BMJ open
BMJ Open
15
3
10.1136/bmjopen-2024-090492
eng
2,025
3
13
2,025
3
13
[INTRODUCTION] In England, eligible adults aged 40-74 years are invited to attend a face-to-face (F2F) NHS Health Check appointment every 5 years. A digital version of the Health Check was introduced by a local authority as an alternative for those hesitant or less able to attend an F2F appointment. [OBJECTIVES] This q...
Health Services Accessibility; QUALITATIVE RESEARCH; Quality in healthcare; eHealth
1.016
176
Medicine
Medicine
2,024
40,081,905
Clinical presentation and prognosis of acute symptomatic pulmonary embolism in patients with concomitant upper-extremity versus lower-extremity deep vein thrombosis.
Thorax
Thorax
80
6
10.1136/thorax-2024-221960
eng
2,025
5
20
2,025
5
20
[BACKGROUND] The impact of deep vein thrombosis (DVT) location on acute pulmonary embolism (PE) prognosis remains uncertain. [METHODS] Using the Registro Informatizado de Enfermedad TromboEmbólica registry, we assessed 30-day and 90-day outcomes in patients with acute symptomatic PE and concomitant upper-extremity (UED...
Pulmonary Embolism
2.448
259
Pulmonary and Respiratory Medicine
Medicine
2,024
40,081,747
Dropped Lens Fragments Retrieval Using Endoscopy-Assisted Pars Plana Vitrectomy in Patients With Corneal Opacity.
American journal of ophthalmology
Am J Ophthalmol
274
null
10.1016/j.ajo.2025.03.012
eng
2,025
6
null
2,025
3
11
[PURPOSE] To characterize the surgical outcomes of endoscopy-assisted pars plana vitrectomy (E-PPV) in dropped lens fragments retrieval in patients with corneal opacity. [BACKGROUND] Corneal opacity may delay dropped lens fragment retrieval because of limited fundus view. E-PPV permits posterior segment visualization t...
null
2.103
221
Ophthalmology
Medicine
2,024
40,081,617
Factors Associated with Retinal Detachment after Pediatric Cataract Surgery in the IRIS® Registry.
Ophthalmology
Ophthalmology
132
8
10.1016/j.ophtha.2025.03.003
eng
2,025
8
null
2,025
3
11
[PURPOSE] This study leverages the American Academy of Ophthalmology's IRIS® Registry (Intelligent Research in Sight) to identify factors associated with retinal detachment (RD) after pediatric cataract surgery. [DESIGN] Retrospective cohort study. [PARTICIPANTS] All children (age 18 years) who underwent cataract surg...
Pediatric cataract surgery; Retinal detachment; Risk factors
4.552
297
Ophthalmology
Medicine
2,024
40,081,126
The impact of complication-sensitive risk models on hospital benchmarking for failure to rescue.
Surgery
Surgery
182
null
10.1016/j.surg.2025.109323
eng
2,025
6
null
2,025
3
13
[BACKGROUND] Failure to rescue has been increasingly used as a surgical quality metric, although implementation with complication-agnostic risk models may disproportionately penalize centers that care for high-risk patients. We used a nationally representative database to assess the impact of complication-sensitive ris...
null
null
null
null
null
null
40,080,776
Ensuring Representation: A Scoping Review of Interventions to Increase Minority Participation in Cancer-Related Research.
JCO oncology practice
JCO Oncol Pract
null
null
10.1200/OP-24-00468
eng
2,025
3
13
2,025
3
13
[PURPOSE] Minority representation in cancer-related clinical trials (CCTs) is often inadequate. This poses a threat to the generalizability of studies and risks promoting health inequities. This scoping review set out to examine strategies to promote minority participation in CCTs and across the entire continuity of ca...
null
2.346
85
Health Policy; Oncology; Oncology
Medicine; Nursing
2,024
40,080,115
Severe acute respiratory syndrome coronavirus-2 antibody prevalence in adults with HIV.
AIDS (London, England)
AIDS
39
9
10.1097/QAD.0000000000004180
eng
2,025
7
15
2,025
3
13
[OBJECTIVES] To measure severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody seroprevalence within a cohort of adults with HIV and correlate demographics with response rates to SARS CoV-2 vaccination. [DESIGN] Initial vaccine trials for SARS CoV-2 did not examine efficacy in people with HIV. We underto...
HIV; antibody; coronavirus disease; coronavirus disease-19; severe acute respiratory syndrome coronavirus-2; vaccination; vaccine
1.209
233
Infectious Diseases; Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,024