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10.1101/19000109 | Molecular profiling of neonatal dried blood spots reveals changes in innate and adaptive immunity following fetal inflammatory response | Daniel Costa; Nuria Bonet; Amanda Sole; Jose Manuel Gonzalez de Aledo-Castillo; Eduard Sabido; Ferran Casals; Carlota Rovira; Alfons Nadal; Jose Luis Marin; Teresa Cobo; Robert Castelo | Robert Castelo | Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain; Research Programme on Biomedical Informatics, Institut Hospita | 2019-06-25 | 1 | null | cc_by | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/06/25/19000109.source.xml | The fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI) following FIR. The link be... | 10.1111/febs.15578 | medrxiv |
10.1101/19000109 | Molecular profiling of neonatal dried blood spots reveals changes in innate and adaptive immunity following fetal inflammatory response | Costa, D.; Bonet, N.; Sole, A.; Gonzalez de Aledo-Castillo, J. M.; Sabido, E.; Casals, F.; Rovira, C.; Nadal, A.; Marin, J. L.; Cobo, T.; Castelo, R. | Robert Castelo | Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain; Research Programme on Biomedical Informatics, Institut Hospita | 2019-07-09 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/07/09/19000109.source.xml | The fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI) following FIR. The link be... | 10.1111/febs.15578 | medrxiv |
10.1101/19000109 | Genome-wide postnatal changes in immunity following fetal inflammatory response | Costa, D.; Bonet, N.; Sole, A.; Gonzalez de Aledo-Castillo, J. M.; Sabido, E.; Casals, F.; Rovira, C.; Nadal, A.; Marin, J. L.; Cobo, T.; Castelo, R. | Robert Castelo | Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain; Research Programme on Biomedical Informatics, Institut Hospita | 2020-03-16 | 3 | PUBLISHAHEADOFPRINT | cc_by | genetic and genomic medicine | https://www.medrxiv.org/content/early/2020/03/16/19000109.source.xml | The fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI) following FIR. The link be... | 10.1111/febs.15578 | medrxiv |
10.1101/19000109 | Genome-wide postnatal changes in immunity following fetal inflammatory response | Costa, D.; Bonet, N.; Sole, A.; Gonzalez de Aledo-Castillo, J. M.; Sabido, E.; Casals, F.; Rovira, C.; Nadal, A.; Marin, J. L.; Cobo, T.; Castelo, R. | Robert Castelo | Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain; Research Programme on Biomedical Informatics, Institut Hospita | 2020-07-24 | 4 | PUBLISHAHEADOFPRINT | cc_by | genetic and genomic medicine | https://www.medrxiv.org/content/early/2020/07/24/19000109.source.xml | The fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI) following FIR. The link be... | 10.1111/febs.15578 | medrxiv |
10.1101/19000109 | Genome-wide postnatal changes in immunity following fetal inflammatory response | Costa, D.; Bonet, N.; Sole, A.; Gonzalez de Aledo-Castillo, J. M.; Sabido, E.; Casals, F.; Rovira, C.; Nadal, A.; Marin, J. L.; Cobo, T.; Castelo, R. | Robert Castelo | Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain; Research Programme on Biomedical Informatics, Institut Hospita | 2020-09-25 | 5 | PUBLISHAHEADOFPRINT | cc_by | genetic and genomic medicine | https://www.medrxiv.org/content/early/2020/09/25/19000109.source.xml | The fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI) following FIR. The link be... | 10.1111/febs.15578 | medrxiv |
10.1101/19000273 | Crohns disease and ulcerative colitis patient perspectives on clinical trials and participation | Orna G Ehrlich; James Testaverde; Caren Heller; Stuart Daman; Annick Anderson; Peter D.R. Higgins | Orna G Ehrlich | Crohn\'s & Colitis Foundation | 2019-06-25 | 1 | null | cc_by_nc_nd | gastroenterology | https://www.medrxiv.org/content/early/2019/06/25/19000273.source.xml | BackgroundClinical trial recruitment is often the rate-limiting step in the development of new treatments reaching patients across all disease states. With more than 1500 currently available clinical trials for inflammatory bowel diseases (IBD) patients, it is important to understand patient perceptions of clinical tri... | null | medrxiv |
10.1101/19000463 | Updating Insights into Rosiglitazone and Cardiovascular Risk through Shared Data: Individual Patient-and-Summary-Level Meta-Analyses | Joshua D Wallach; Kun Wang; Audrey D Zhang; Deanna Chang; Holly K Grossetta Nardini; Haiqun Lin; Michael B Bracken; Mayur Desai; Harlan Krumholz; Joseph S. Ross | Joshua D Wallach | Yale School of Public Health | 2019-06-25 | 1 | null | cc_by_nc | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/06/25/19000463.source.xml | ObjectiveTo conduct a systematic review and meta-analysis of the effects of rosiglitazone therapy on cardiovascular risk and mortality using multiple data sources and varying analytical approaches.
DesignSystematic review and meta-analysis of randomized controlled trials.
Data sourcesGlaxoSmithKlines (GSK) Clinical S... | 10.1136/bmj.l7078 | medrxiv |
10.1101/19000430 | Predicting epileptic seizures using nonnegative matrix factorization | Olivera Stojanovic; Gordon Pipa | Olivera Stojanovic | Institute of Cognitive Science, University of Osnabrueck | 2019-06-25 | 1 | null | cc_by | health informatics | https://www.medrxiv.org/content/early/2019/06/25/19000430.source.xml | This paper presents a procedure for the patient-specific prediction of epileptic seizures. To this end, a combination of nonnegative matrix factorization (NMF) and smooth basis functions with robust regression is applied to power spectra of intracranial electroencephalographic (iEEG) signals. The resulting time and fre... | 10.1371/journal.pone.0228025 | medrxiv |
10.1101/19000133 | Prospective and External Evaluation of a Machine Learning Model to Predict In-Hospital Mortality | Nathan Brajer; Brian Cozzi; Michael Gao; Mike Revoir; Marshall Nichols; Joseph Futoma; Jonathan Bae; Noppon Setji; Suresh Balu; Adrian Hernandez; Mark Sendak | Nathan Brajer | Duke University School of Medicine | 2019-06-25 | 1 | null | cc_by_nc_nd | health systems and quality improvement | https://www.medrxiv.org/content/early/2019/06/25/19000133.source.xml | The ability to accurately predict in-hospital mortality for patients at the time of admission could improve clinical and operational decision-making and outcomes. Few machine learning models have been developed to predict in-hospital death that are both broadly applicable to all adult patients across a health system an... | 10.1001/jamanetworkopen.2019.20733 | medrxiv |
10.1101/19000919 | Trends and variation in unsafe prescribing of methotrexate: a cohort study in English NHS primary care. | Brian MacKenna; Helen J Curtis; Alex J Walker; Richard Croker; Seb Bacon; Ben Goldacre | Ben Goldacre | University of Oxford | 2019-06-25 | 1 | null | cc_by | health systems and quality improvement | https://www.medrxiv.org/content/early/2019/06/25/19000919.source.xml | ObjectiveTo describe trends and geographical variation in methotrexate prescribing that breaches national safety recommendations; deaths from methotrexate poisoning; and associated litigation.
MethodsA retrospective cohort study of English NHS primary care prescribing data, complemented by information obtained through... | 10.3399/bjgp20X710993 | medrxiv |
10.1101/19000919 | Trends and variation in unsafe prescribing of methotrexate: a cohort study in English NHS primary care. | MacKenna, B.; Curtis, H. J.; Walker, A. J.; Croker, R.; Bacon, S.; Goldacre, B. | Ben Goldacre | University of Oxford | 2019-07-02 | 2 | PUBLISHAHEADOFPRINT | cc_by | health systems and quality improvement | https://www.medrxiv.org/content/early/2019/07/02/19000919.source.xml | ObjectiveTo describe trends and geographical variation in methotrexate prescribing that breaches national safety recommendations; deaths from methotrexate poisoning; and associated litigation.
MethodsA retrospective cohort study of English NHS primary care prescribing data, complemented by information obtained through... | 10.3399/bjgp20X710993 | medrxiv |
10.1101/19000596 | 18F-AV1451 PET imaging and white matter changes in progressive supranuclear palsy | Nicolas Nicastro; Patricia Vazquez Rodriguez; Maura Malpetti; W. Richard Bevan-Jones; P. Simon Jones; Luca Passamonti; Franklin I Aigbirhio; John T O'Brien; James B Rowe | Nicolas Nicastro | University of Cambridge | 2019-06-25 | 1 | null | cc_by_nc_nd | neurology | https://www.medrxiv.org/content/early/2019/06/25/19000596.source.xml | IntroductionProgressive supranuclear palsy (PSP) is characterized by deposition of straight filament tau aggregates in the grey matter of deep nuclei and cerebellum. White matter changes are increasingly documented as a feature of degenerative parkinsonism. We therefore examined the relationship between tau pathology (... | 10.1007/s00415-019-09566-9 | medrxiv |
10.1101/19000265 | Perception of whole-body motion during balance perturbations is impaired in Parkinson's disease and is associated with balance impairment | Sistania M Bong; JL McKay; Stewart A Factor; Lena H Ting | Lena H Ting | Emory University | 2019-06-25 | 1 | null | cc_by | neurology | https://www.medrxiv.org/content/early/2019/06/25/19000265.source.xml | BackgroundIn addition to motor deficits, Parkinsons disease (PD) may cause perceptual impairments. The role of perceptual impairments in sensorimotor function is unclear, and has typically been studied in single-joint motions. Research Question: We hypothesized that perception of whole-body motion is impaired in PD and... | 10.1016/j.gaitpost.2019.10.029 | medrxiv |
10.1101/19000497 | Proximal and distal factors predicting timely initiation of breastfeeding in Ethiopia: a systematic review and meta-analysis | Tesfa Dejenie Habtewold; Shimels Hussien Mohammed; Aklilu Endalamaw; Henok Mulugeta; Getenet Dessie; Derbew Fikadu Berhe; Mulugeta Molla Birhanu; Md. Atiqul Islam; Andreas A. Teferra; Nigus Gebremedhin Asefa; Sisay Mulugeta Alemu | Tesfa Dejenie Habtewold | Department of Epidemiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands | 2019-06-25 | 1 | null | cc_by_nc_nd | nutrition | https://www.medrxiv.org/content/early/2019/06/25/19000497.source.xml | BackgroundIn Ethiopia, the current coverage of timely initiation of breast feeding (TIBF) has fallen short of the national Health Sector Transformation Plan 2016-2020, National Nutrition Program 2016-2020 and WHO global target. This calls for the need to assess relevant proximal and distal factors that affect the rate ... | 10.1111/apa.15278 | medrxiv |
10.1101/19000497 | Proximal and distal factors predicting timely initiation of breastfeeding in Ethiopia: a systematic review and meta-analysis | Habtewold, T. D.; Mohammed, S. H.; Endalamaw, A.; Mulugeta, H.; Dessie, G.; Berhe, D. F.; Birhanu, M. M.; Islam, M. A.; Teferra, A. A.; Asefa, N. G.; Alemu, S. M. | Tesfa Dejenie Habtewold | Department of Epidemiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands | 2019-07-08 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | nutrition | https://www.medrxiv.org/content/early/2019/07/08/19000497.source.xml | BackgroundIn Ethiopia, the current coverage of timely initiation of breast feeding (TIBF) has fallen short of the national Health Sector Transformation Plan 2016-2020, National Nutrition Program 2016-2020 and WHO global target. This calls for the need to assess relevant proximal and distal factors that affect the rate ... | 10.1111/apa.15278 | medrxiv |
10.1101/19000638 | Transfer of Statistical Innovations of the 1990s-2000s in Oncology to the Biomedical Literature | Alexandre Vivot; Vincent Levy; Sylvie Chevret | Alexandre Vivot | APHP | 2019-06-25 | 1 | null | cc_no | oncology | https://www.medrxiv.org/content/early/2019/06/25/19000638.source.xml | IntroductionInnovations in the fields of clinical studies require time to generate and disseminate new knowledge. We aimed to specifically explore lag times between the introduction and widespread use of innovative statistical methods in oncology using the competing risks and phase I model-based clinical trials setting... | null | medrxiv |
10.1101/19000174 | Histopathologist Features Predictive of Diagnostic Concordance at Expert Level Amongst a Large International Sample of Pathologists Diagnosing Barrett′s Dysplasia Using Digital Pathology | Myrtle J Van der Wel; Helen G Coleman; Jacques JGHM Bergman; Marnix Jansen; Sybren L Meijer | Marnix Jansen | UCL Cancer Institute | 2019-06-25 | 1 | null | cc_no | oncology | https://www.medrxiv.org/content/early/2019/06/25/19000174.source.xml | ObjectiveGuidelines recommend expert pathology review of Barretts oesophagus (BO) biopsies that reveal dysplasia, but there are no evidence-based standards to corroborate expert reviewer status. We investigated BO concordance rates and pathologist features predictive of diagnostic discordance amongst a large internatio... | 10.1136/gutjnl-2019-318985 | medrxiv |
10.1101/19000653 | Pain Reduction by Inducing Sensory-Motor Adaptation in Complex Regional Pain Syndrome (CRPS PRISMA): Protocol for a Double-blind Randomized Controlled Trial | Monika Halicka; Axel D Vittersø; Michael J Proulx; Janet H Bultitude | Monika Halicka | University of Bath | 2019-06-25 | 1 | null | cc_by_nc_nd | pain medicine | https://www.medrxiv.org/content/early/2019/06/25/19000653.source.xml | BackgroundComplex Regional Pain Syndrome (CRPS) presents as chronic, continuous pain and sensory, autonomic, and motor abnormalities affecting one or more extremities. People with CRPS can also show changes in their perception of and attention to the affected body part and sensory information in the affected side of sp... | 10.1186/s12883-020-1604-z | medrxiv |
10.1101/19000653 | Pain Reduction by Inducing Sensory-Motor Adaptation in Complex Regional Pain Syndrome (CRPS PRISMA): Protocol for a Double-blind Randomized Controlled Trial | Halicka, M.; Vitterso, A. D.; Proulx, M. J.; Bultitude, J. H. | Monika Halicka | University of Bath | 2020-01-03 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | pain medicine | https://www.medrxiv.org/content/early/2020/01/03/19000653.source.xml | BackgroundComplex Regional Pain Syndrome (CRPS) presents as chronic, continuous pain and sensory, autonomic, and motor abnormalities affecting one or more extremities. People with CRPS can also show changes in their perception of and attention to the affected body part and sensory information in the affected side of sp... | 10.1186/s12883-020-1604-z | medrxiv |
10.1101/19000562 | Limitations of machine learning in psychiatry: Participation in the PAC 2018 depression challenge | Fabian Eitel; Sebastian Stober; Lea Waller; Lena Dorfschmidt; Henrik Walter; Kerstin Ritter | Kerstin Ritter | Charite - Universitaetsmedizin Berlin | 2019-06-25 | 1 | null | cc_by_nc | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/06/25/19000562.source.xml | The authors have withdrawn this manuscript because the results were posted in error. The authors do not wish this work to be cited as reference for the project. Please contact the corresponding author if you have any questions. | null | medrxiv |
10.1101/19000562 | Limitations of machine learning in psychiatry: Participation in the PAC 2018 depression challenge | Eitel, F.; Stober, S.; Waller, L.; Dorfschmidt, L.; Walter, H.; Ritter, K. | Kerstin Ritter | Charite - Universitaetsmedizin Berlin | 2019-07-08 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/07/08/19000562.source.xml | The authors have withdrawn this manuscript because the results were posted in error. The authors do not wish this work to be cited as reference for the project. Please contact the corresponding author if you have any questions. | null | medrxiv |
10.1101/19000562 | Limitations of machine learning in psychiatry: Participation in the PAC 2018 depression challenge | Eitel, F.; Stober, S.; Waller, L.; Dorfschmidt, L.; Walter, H.; Ritter, K. | Kerstin Ritter | Charite - Universitaetsmedizin Berlin | 2019-08-05 | 3 | WITHDRAWN | cc_by_nc | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/08/05/19000562.source.xml | The authors have withdrawn this manuscript because the results were posted in error. The authors do not wish this work to be cited as reference for the project. Please contact the corresponding author if you have any questions. | null | medrxiv |
10.1101/19000166 | Gait differences in patients with multiple sclerosis who have low and high levels of disability. | John J Fraser; Jeannie Stephensen | John J Fraser | Physical Therapy Program, Department of Biology, The College of Staten Island City University of New York, Staten Island, NY | 2019-06-25 | 1 | null | cc0 | rehabilitation medicine and physical therapy | https://www.medrxiv.org/content/early/2019/06/25/19000166.source.xml | BackgroundMultiple Sclerosis (MS) often results in gait impairment and disability.
ObjectiveTo investigate differences in spatiotemporal gait characteristics of people with MS who have low versus high levels of disability. Between trial and inter-limb consistency and the association of gait variables with level of dis... | null | medrxiv |
10.1101/19000356 | Metabolomics in juvenile-onset SLE: identifying new biomarkers to predict cardiovascular risk | George A Robinson; Leda Coelewij; Ania Radziszewska; Chris Wincup; Hannah Peckham; Kirsty Waddington; David A Isenberg; Yiannis Ioannou; Coziana Ciurtin; Ines Pineda-Torra; Elizabeth C Jury | Elizabeth C Jury | University College London | 2019-06-25 | 1 | null | cc_no | rheumatology | https://www.medrxiv.org/content/early/2019/06/25/19000356.source.xml | BACKGROUNDJuvenile-onset systemic lupus erythematosus (JSLE) is an autoimmune disorder characterised by immune dysregulation, chronic inflammation and increased cardiovascular risk (CVR). Cardiovascular disease is the leading cause of mortality in JSLE patients not attributable to disease flares. However, it is not pos... | 10.1016/j.ebiom.2021.103243 | medrxiv |
10.1101/19000687 | Electrocardiographic Changes After Completion of a Triathlon | Caroline Hosatte-Ducassy; Jose Correa; Francois Lalonde; Rohit Mohindra; Michael Chetrit; Gregory Marton; Audrey Marcotte; Francois Tournoux; Eileen Bridges | Caroline Hosatte-Ducassy | McGill University, Department of Emergency Medicine | 2019-06-25 | 1 | null | cc_by_nc_nd | sports medicine | https://www.medrxiv.org/content/early/2019/06/25/19000687.source.xml | ObjectivesGiven the increasing popularity of long-distance triathlon events amongst amateur athlete and the difficulty for emergency physician to address cardiovascular complaints in the context of exercise, this study aims to:
- Identify the prevalence of electrocardiographic abnormalities before and after a long dis... | 10.1002/tsm2.134 | medrxiv |
10.1101/19001024 | Disease overarching mechanisms that explain and predict outcome of patients with high cardiovascular risk: rationale and design of the Berlin Long-term Observation of Vascular Events (BeLOVE) study | Bob Siegerink; Joachim Weber; Michael Ahmadi; Kai-Uwe Eckardt; Frank Edelmann; Matthias Endres; Holger Gerhardt; Katrin Haubold; Norbert Hübner; Ulf Landmesser; david Leistner; Knut Mai; Dominik N. N. Müller; Burkert Pieske; Geraldine Rauch; Sein Schmidt; Kai Schmidt-Ott; Jeanette Schulz-Menger; Joachim Spranger; Tobia... | Tobias Pischon | Berlin Institute of Health (BIH) & German Center for Cardiovascular Research (DZHK) & Charité Universitätsmedizin & Max-Delbrück Center for Molecular Medicine i | 2019-06-27 | 1 | null | cc_by_nc | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/06/27/19001024.source.xml | BackgroundCardiovascular disease (CVD) is the leading cause of premature death worldwide. Effective and individualized treatment requires exact knowledge about both risk factors and risk estimation. Most evidence for risk prediction currently comes from population-based studies on first incident cardiovascular events. ... | null | medrxiv |
10.1101/19001024 | Disease overarching mechanisms that explain and predict outcome of patients with high cardiovascular risk: rationale and design of the Berlin Long-term Observation of Vascular Events (BeLOVE) study | Siegerink, B.; Weber, J.; Ahmadi, M.; Eckardt, K.-U.; Edelmann, F.; Endres, M.; Gerhardt, H.; Haubold, K.; Hübner, N.; Landmesser, U.; Leistner, D.; Mai, K.; Müller, D. N.; Pieske, B.; Rauch, G.; Schmidt, S.; Schmidt-Ott, K. M.; Schulz-Menger, J.; Spranger, J.; Pischon, T. | Tobias Pischon | Berlin Institute of Health (BIH) & German Center for Cardiovascular Research (DZHK) & Charité Universitätsmedizin & Max-Delbrück Center for Molecular Medicine i | 2019-07-15 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/07/15/19001024.source.xml | BackgroundCardiovascular disease (CVD) is the leading cause of premature death worldwide. Effective and individualized treatment requires exact knowledge about both risk factors and risk estimation. Most evidence for risk prediction currently comes from population-based studies on first incident cardiovascular events. ... | null | medrxiv |
10.1101/19000786 | Nutritional Supplementation during Pulmonary Rehabilitation in COPD: A Systematic Review | Abdulelah Aldhahir; John Hurst; Swapna Mandal; Ahmed Alrajeh; Yousef Aldabayan; Jaber Alqahtani; Salifu Drammeh; Vanitha Subbu | Abdulelah Aldhahir | University College London | 2019-06-28 | 1 | null | cc_by_nc_nd | nutrition | https://www.medrxiv.org/content/early/2019/06/28/19000786.source.xml | BackgroundUptake of nutritional supplementation during pulmonary rehabilitation (PR) for people with chronic obstructive pulmonary disease (COPD) has been limited by an absence of rigorous evidence-based studies supporting use. Our objective were to report and summarise the current evidence supporting use of nutritiona... | 10.1177/1479973120904953 | medrxiv |
10.1101/19000661 | Comparative analysis of functional assay evidence use by ClinGen Variant Curation Expert Panels | Dona M. Kanavy; Shannon M. McNulty; Meera K. Jairath; Sarah E. Brnich; Chris Bizon; Bradford C. Powell; Jonathan S. Berg | Jonathan S. Berg | University of North Carolina at Chapel Hill | 2019-06-28 | 1 | null | cc_by_nc_nd | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/06/28/19000661.source.xml | BackgroundThe 2015 American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) guidelines for clinical sequence variant interpretation state that "well-established" functional studies can be used as evidence in variant classification. These guidelines articulated key attribute... | 10.1186/s13073-019-0683-1 | medrxiv |
10.1101/19000521 | Association of puberty timing with Type 2 diabetes: Systematic review and meta-analysis | Tuck Seng Cheng; Felix R. Day; Rajalakshmi Lakshman; Ken K. Ong | Tuck Seng Cheng | University of Cambridge | 2019-06-28 | 1 | null | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/06/28/19000521.source.xml | OBJECTIVEWe aimed to systematically review published evidence on the association between puberty timing and Type 2 diabetes or impaired glucose tolerance (T2D/IGT), with and without adjustment for adiposity, and to estimate its potential contribution to the burden of T2D.
RESEARCH DESIGN AND METHODSWe searched PubMed,... | 10.1371/journal.pmed.1003017 | medrxiv |
10.1101/19001123 | Epigenetic prediction of major depressive disorder | Miruna C Barbu; Rosie M Walker; David M Howard; Kathryn L Evans; Heather C Whalley; David J Porteous; Stewart W Morris; Ian J Deary; Riccardo E Marioni; Toni-Kim Clarke; Andrew M McIntosh | Andrew M McIntosh | University of Edinburgh | 2019-06-28 | 1 | null | cc_by | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/06/28/19001123.source.xml | ObjectiveDNA methylation (DNAm) is associated with environmental risk factors for major depressive disorder (MDD) but has not yet been tested for its ability to discriminate individuals with MDD from unaffected individuals.
MethodsUsing penalized regression based on genome-wide CpG methylation, we trained a DNAm risk ... | 10.1038/s41380-020-0808-3 | medrxiv |
10.1101/19001115 | Forecasting the impact of population ageing on tuberculosis incidence | Chu-Chang Ku; Peter J Dodd | Chu-Chang Ku | School of Health and Related Research, University of Sheffield | 2019-06-28 | 1 | null | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/06/28/19001115.source.xml | BackgroundTuberculosis (TB) disease reactivates from distant latent infection or recent (re)infection. Progression risks increase with age. Across the World Health Organisation Western Pacific region, many populations are ageing and have the highest per capita TB incidence rates in older age groups. However, methods fo... | 10.1371/journal.pone.0222937 | medrxiv |
10.1101/19001008 | Current characteristics and outcomes of Cytomegalovirus Reactivation in kidney transplant seropositive recipients in the era of prophylaxis treatment. Lesson from single Moroccan center experience. | REZZOUK, B.; Bouattar, T.; Belkadi, B.; Razine, R.; Bayahia, R.; Ouzeddoun, N.; Benamar, L.; Rhou, H.; Bouihat, N.; Ibrahimi, A.; Seffar, M.; Kabbaj, H. | Bouchra REZZOUK | Laboratory of Microbiology and Molecular Biology, Faculty of Science, University Mohammed V, Rabat, Morocco. | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | infectious diseases | https://www.medrxiv.org/content/early/2019/06/28/19001008.source.xml | Despite the use of antiviral prophylaxis, the active cytomegalovirus (CMV) replication is still occurred in the seropositive kidney recipients. The aim of this study was to assess the incidence of CMV reactivation and potential risk factors associated with CMV disease. Data of sixty kidney transplant recipients who had... | 10.2147/trrm.s278655 | medrxiv |
10.1101/19001016 | Medication errors during simulated paediatric resuscitations: a prospective, observational human reliability analysis | Appelbaum, N.; Clarke, J.; Feather, C.; Franklin, B.; Sinha, R.; Pratt, P.; Maconochie, I.; Darzi, A. | Calandra Feather | NIHR-Imperial Patient Safety Translational Research Centre, Imperial College London | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by | pediatrics | https://www.medrxiv.org/content/early/2019/06/28/19001016.source.xml | IntroductionMedication errors during paediatric resuscitation are thought to be common. However, there is little evidence about the individual process steps that contribute to such medication errors in this context.
ObjectivesTo describe the incidence, nature and severity of medication errors in simulated paediatric r... | 10.1136/bmjopen-2019-032686 | medrxiv |
10.1101/19001016 | Medication errors during simulated paediatric resuscitations: a prospective, observational human reliability analysis | Appelbaum, N.; Clarke, J.; Feather, C.; Dean Franklin, B.; Sinha, R.; Pratt, P.; Maconochie, I.; Darzi, A. | Calandra Feather | NIHR-Imperial Patient Safety Translational Research Centre, Imperial College London | 2019-08-02 | 2 | PUBLISHAHEADOFPRINT | cc_by | pediatrics | https://www.medrxiv.org/content/early/2019/08/02/19001016.source.xml | IntroductionMedication errors during paediatric resuscitation are thought to be common. However, there is little evidence about the individual process steps that contribute to such medication errors in this context.
ObjectivesTo describe the incidence, nature and severity of medication errors in simulated paediatric r... | 10.1136/bmjopen-2019-032686 | medrxiv |
10.1101/19000422 | The nature of clusters of multimorbid patients in the UK: a latent class analysis. | Zhu, Y.; Edwards, D.; Payne, R. A.; Kiddle, S. | Yajing Zhu | MRC Biostatistics Unit, University of Cambridge | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/06/28/19000422.source.xml | BackgroundMultimorbidity is one of the principal challenges facing health systems worldwide. To help understand the changes to services and policies that are required to deliver better care, we used a novel approach to investigate which diseases co-occur and how combinations are associated with mortality and service us... | 10.1016/S0140-6736(19)32899-5 | medrxiv |
10.1101/19000422 | Characteristics, service use and mortality of clusters of multimorbid patients in England: a population-based study | Zhu, Y.; Edwards, D.; Mant, J.; Payne, R. A.; Kiddle, S. | Yajing Zhu | MRC Biostatistics Unit, University of Cambridge | 2019-12-02 | 2 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/12/02/19000422.source.xml | BackgroundMultimorbidity is one of the principal challenges facing health systems worldwide. To help understand the changes to services and policies that are required to deliver better care, we used a novel approach to investigate which diseases co-occur and how combinations are associated with mortality and service us... | 10.1016/S0140-6736(19)32899-5 | medrxiv |
10.1101/19000646 | Big Five Personality Traits Influence Tinnitus Improvement Over Time | Simoes, J. P.; Schlee, W.; Schecklmann, M.; Langguth, B.; Farahmand, D.; Neff, P. | Jorge Piano Simoes | University of Regensburg | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/06/28/19000646.source.xml | Previous studies investigating the relation between personality and tinnitus distress showed that high neuroticism and low extraversion scores are related to higher tinnitus distress measured by the Tinnitus Handicap Inventory (THI) and the Tinnitus Questionnaire (TQ). However, little is known about the role of persona... | 10.1038/s41598-019-53845-4 | medrxiv |
10.1101/19000190 | Cost-Sensitive Machine Learning Classification for Mass Tuberculosis Screening | Septiandri, A. A.; Aditiawarman, A.; Tjiong, R.; Burhan, E.; Shankar, A. H. | Ali Akbar Septiandri | Inovasi Sehat Indonesia | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | health informatics | https://www.medrxiv.org/content/early/2019/06/28/19000190.source.xml | Active screening for Tuberculosis (TB) is needed to optimize detection and treatment. However, current algorithms for verbal screening perform poorly, causing misclassification that leads to missed cases and unnecessary and costly laboratory tests for false positives. We investigated the role of machine learning to imp... | null | medrxiv |
10.1101/19000554 | Integrating Online Georeferenced Epidemiological Analysis and Visualization into a Telemedicine Infrastructure - First Results | von Wangenheim, A.; Savaris, A.; Borgatto, A. F.; Inacio, A. D. S. | Aldo von Wangenheim | Federal University of Santa Catarina - UFSC | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | health informatics | https://www.medrxiv.org/content/early/2019/06/28/19000554.source.xml | With the objective to perform a first evaluation of the impact of the integration of a graphic spatial epidemiology tool that allows quasi-realtime georeferenced data visualization into a telemedicine infrastructure, this work presents GISTelemed, an online module specialized on indexing structured and semi-structured ... | null | medrxiv |
10.1101/19000570 | Maternal Mortality and Women's Political Participation | Bhalotra, S. R.; Clarke, D.; Gomes, J.; Venkataramani, A. S. | Atheendar S Venkataramani | University of Pennsylvania | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_no | health policy | https://www.medrxiv.org/content/early/2019/06/28/19000570.source.xml | We show that large declines in maternal mortality can be achieved by raising womens political participation. We estimate that the recent wave of quotas for women in parliament in low income countries has resulted in a 9 to 12% decline in maternal mortality. Among mechanisms are that gender quotas lead to an 8 to 10% in... | null | medrxiv |
10.1101/19000844 | An acute bleomycin inflammatory and fibrotic mouse model of morphea is dependent upon CXCL9 and CXCR3 | Richmond, J. M.; Patel, D.; Watanabe, T.; Garelli, C.; Garg, M.; Dresser, K.; Deng, A.; Feghali-Bostwick, C. A.; Harris, J. E.; Jacobe, H. T. | Heidi T Jacobe | University of Texas Southwestern Medical Center | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | dermatology | https://www.medrxiv.org/content/early/2019/06/28/19000844.source.xml | Morphea, or localized scleroderma, is characterized by an inflammatory phase followed by cutaneous fibrosis, which may lead to disfigurement and/or disability. Previous work from our group showed that the CXCR3 ligands CXCL9 and CXCL10 are highly upregulated in lesional skin of morphea patients. Here, we used an acute ... | 10.1016/j.jid.2022.11.025 | medrxiv |
10.1101/19000851 | SEXUAL BEHAVIOURS AND EXPERIENCE OF SEXUAL COERCION AMONG IN-SCHOOL FEMALE ADOLESCENT IN SOUTHWESTERN NIGERIA | Owolodun, B. S.; Sanusi, R. A. | Babatunde Samuel Owolodun | University of Ibadan | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | public and global health | https://www.medrxiv.org/content/early/2019/07/03/19000851.source.xml | Most people begin their sexual relationship during adolescence and some get involved in risky life threatening behaviors such as unwanted pregnancies, abortions and sexually transmitted infections. This study was therefore designed to understand the patterns of female adolescents sexual behaviours and sexual coercion e... | null | medrxiv |
10.1101/19000711 | Robotic middle ear access for cochlear implantation: first in man | Caversaccio, M.; Wimmer, W.; Anso, J.; Mantokoudis, G.; Gerber, N.; Rathgeb, C.; Schneider, D.; Hermann, J.; Wagner, F.; Scheidegger, O.; Huth, M.; Anschuetz, L.; Kompis, M.; Williamson, T.; Bell, B.; Gavaghan, K.; Weber, S. | Wilhelm Wimmer | Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | otolaryngology | https://www.medrxiv.org/content/early/2019/07/03/19000711.source.xml | To demonstrate the feasibility of robotic middle ear access in a clinical setting, nine adult patients with severe-to-profound hearing loss indicated for cochlear implantation were included in this clinical trial. A keyhole access tunnel to the tympanic cavity and targeting the round window was planned based on preoper... | 10.1371/journal.pone.0220543 | medrxiv |
10.1101/19000307 | Framework for rational donor selection in fecal microbiota transplant clinical trials | Duvallet, C.; Zellmer, C.; Panchal, P.; Budree, S.; Osman, M.; Alm, E. | Eric Alm | Massachusetts Institute of Technology | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by | gastroenterology | https://www.medrxiv.org/content/early/2019/07/03/19000307.source.xml | Early clinical successes are driving enthusiasm for fecal microbiota transplantation (FMT), the transfer of healthy gut bacteria through whole stool, as emerging research is linking the microbiome to many different diseases. However, preliminary trials have yielded mixed results and suggest that heterogeneity in donor ... | 10.1371/journal.pone.0222881 | medrxiv |
10.1101/19000307 | Framework for rational donor selection in fecal microbiota transplant clinical trials | Duvallet, C.; Zellmer, C.; Panchal, P.; Budree, S.; Osman, M.; Alm, E. | Eric Alm | Massachusetts Institute of Technology | 2019-09-26 | 2 | PUBLISHAHEADOFPRINT | cc_by | gastroenterology | https://www.medrxiv.org/content/early/2019/09/26/19000307.source.xml | Early clinical successes are driving enthusiasm for fecal microbiota transplantation (FMT), the transfer of healthy gut bacteria through whole stool, as emerging research is linking the microbiome to many different diseases. However, preliminary trials have yielded mixed results and suggest that heterogeneity in donor ... | 10.1371/journal.pone.0222881 | medrxiv |
10.1101/19000414 | The effectiveness of digital technology interventions to reduce loneliness in adult people: A protocol for a systematic review and meta-analysis | Shah, S. G. S.; Nogueras, D.; van Woerden, H. C.; Kiparoglou, V. | Syed Ghulam Sarwar Shah | NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by | public and global health | https://www.medrxiv.org/content/early/2019/07/03/19000414.source.xml | IntroductionLoneliness is an emerging public health problem, which is associated with social, emotional, mental and physical health issues. The application of digital technology (DT) interventions to reduce loneliness has increased in recent years. The effectiveness of DT interventions needs to be assessed systematical... | 10.1136/bmjopen-2019-032455 | medrxiv |
10.1101/19000281 | LncRNA and predictive model for improving the diagnosis of clinically diagnosed pulmonary tuberculosis | Hu, X.; Zhang, J.; Liao, S.; Bai, H.; Gupta, S.; Zhou, Y.; Zhou, J.; Wu, Q.; Meng, Z.; Jiao, L.; Wu, L.; Wang, M.; Chen, X.; Zhou, Y.; Lu, X.; Zhang, Z.; Ying, B. | Binwu Ying | Department of Laboratory Medicine, West China Hospital, Sichuan University | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | infectious diseases | https://www.medrxiv.org/content/early/2019/07/03/19000281.source.xml | BackgroundClinically diagnosed pulmonary tuberculosis (PTB) patients lack Mycobacterium tuberculosis (MTB) microbiologic evidence, and misdiagnosis or delayed diagnosis often occurs as a consequence. We investigated the potential of lncRNAs and corresponding predictive models to diagnose these patients.
MethodsWe enro... | 10.1128/jcm.01973-19 | medrxiv |
10.1101/19000281 | LncRNA and predictive model for improving the diagnosis of clinically diagnosed pulmonary tuberculosis | Hu, X.; Chen, H.; Liao, S.; Bai, H.; Gupta, S.; Zhou, Y.; Zhou, J.; Jiao, L.; Wu, L.; Wang, M.; Chen, X.; Zhou, Y.; Lu, X.; Hu, T. Y.; Zhang, Z.; Ying, B. | Binwu Ying | Department of Laboratory Medicine, West China Hospital, Sichuan University | 2019-11-05 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | infectious diseases | https://www.medrxiv.org/content/early/2019/11/05/19000281.source.xml | BackgroundClinically diagnosed pulmonary tuberculosis (PTB) patients lack Mycobacterium tuberculosis (MTB) microbiologic evidence, and misdiagnosis or delayed diagnosis often occurs as a consequence. We investigated the potential of lncRNAs and corresponding predictive models to diagnose these patients.
MethodsWe enro... | 10.1128/jcm.01973-19 | medrxiv |
10.1101/19000927 | Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing | Lohoefer, F. K.; Kaissis, G. A.; Mueller-Leisse, C.; Franz, D.; Katemann, C.; Hock, A.; Peeters, J. M.; Rummeny, E. J.; Karampinos, D.; Braren, R. | Rickmer Braren | TU Muenchen, Institute for diagnostic and interventional Radiology | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | radiology and imaging | https://www.medrxiv.org/content/early/2019/07/03/19000927.source.xml | ObjectivesTo evaluate proton density fat fraction (PDFF) and T2* measurements of the liver with combined parallel imaging (sensitivity encoding, SENSE) and compressed sensing (CS) accelerated chemical shift encoding-based water-fat separation.
MethodsSix-echo Dixon imaging was performed in the liver of 89 subjects. Th... | 10.1371/journal.pone.0224988 | medrxiv |
10.1101/19001149 | Aerobic capacity predicts skeletal but not cardiac muscle damage after a full distance Ironman triathlon - the Iron(wo)man-study | Danielsson, T.; Carlsson, J.; Ten Siethoff, L.; Ahnesjo, J.; Bergman, P. | Patrick Bergman | Linnaeus University | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | sports medicine | https://www.medrxiv.org/content/early/2019/07/03/19001149.source.xml | PurposeThis study examines the association between aerobic capacity and biomarkers of skeletal- and cardiac muscle damage among amateur triathletes after a full distance Ironman.
MethodsMen and women (N=55) were recruited from local sport clubs. One month before an Iron-man triathlon, they conducted a 20m shuttle run ... | 10.1038/s41598-020-57842-w | medrxiv |
10.1101/19001073 | Machine learning to predict early recurrence after oesophageal cancer surgery | Rahman, S.; Walker, R. C.; LLoyd, M. A.; Grace, B. L.; van Boxel, G. I.; Kingma, F. B.; Ruurda, J. P.; van Hillegersberg, R.; Harris, S.; Parsons, S.; Mercer, S.; Griffiths, E. A.; O'Neill, J. R.; Turkington, R.; Fitzgerald, R.; Underwood, T. J.; OCCAMS Consortium, | Timothy J Underwood | Cancer Sciences Unit, University of Southampton, Southampton, UK | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | surgery | https://www.medrxiv.org/content/early/2019/07/03/19001073.source.xml | ObjectiveTo develop a predictive model for early recurrence after surgery for oesophageal adenocarcinoma using a large multi-national cohort.
Summary Background DataEarly cancer recurrence after oesophagectomy is a common problem with an incidence of 20-30% despite the widespread use of neoadjuvant treatment. Quantifi... | 10.1002/bjs.11461 | medrxiv |
10.1101/19001222 | Predicting Residual Function in Hemodialysis and Hemodiafiltration : A Population Kinetic, Decision Analytic Approach | Achakzai, M.; Argyropoulos, C.; Roumelioti, M. - E. | Christos Argyropoulos | Department of Internal Medicine, Division of Nephrology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | nephrology | https://www.medrxiv.org/content/early/2019/07/03/19001222.source.xml | In this study, we introduce a novel framework for the estimation of residual renal function (RRF), based on the population compartmental kinetic behavior of Beta 2 Microglobulin (B2M) and its dialytic removal. Using this model, we simulated a large cohort of patients with various levels of RRF receiving either conventi... | 10.3390/jcm8122080 | medrxiv |
10.1101/19001222 | Predicting Residual Function in Hemodialysis and Hemodiafiltration : A Population Kinetic, Decision Analytic Approach | Achakzai, M.; Argyropoulos, C.; Roumelioti, M. - E. | Christos Argyropoulos | Department of Internal Medicine, Division of Nephrology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA | 2019-07-09 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | nephrology | https://www.medrxiv.org/content/early/2019/07/09/19001222.source.xml | In this study, we introduce a novel framework for the estimation of residual renal function (RRF), based on the population compartmental kinetic behavior of Beta 2 Microglobulin (B2M) and its dialytic removal. Using this model, we simulated a large cohort of patients with various levels of RRF receiving either conventi... | 10.3390/jcm8122080 | medrxiv |
10.1101/19001362 | The impact of involving young children in improving the understanding of a new eye test | Casanova, T.; Black, C.; Rafiq, S.; Hugill, J.; Read, J. C. A.; Vancleef, K. | Kathleen Vancleef | Newcastle University, University of Oxford | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by | ophthalmology | https://www.medrxiv.org/content/early/2019/07/03/19001362.source.xml | BackgroundAlthough considered important, the involvement of young children in research is rare and its impact has never been measured. We aim to provide a good practice example of involvement of young children in the development of a tablet-based 3D eye test or stereotest, ASTEROID. We focus on improving understanding ... | 10.1186/s40900-020-00194-6 | medrxiv |
10.1101/19000877 | A Needs Analysis of Parents Following Sudden Cardiac Death in the Young | McDonald, K.; Sharpe, L.; Yeates, L.; Semsarian, C.; Ingles, J. | Jodie Ingles | Centenary Institute, The University of Sydney | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/07/03/19000877.source.xml | The sudden cardiac death (SCD) of a young person is a devastating event for any parent. Inherited heart disease is often either identified or assumed to be the cause. Few studies have explored the psychosocial impact to the surviving at-risk family members. We sought to investigate the needs of parents who have experie... | 10.1136/openhrt-2019-001120 | medrxiv |
10.1101/19001321 | Accuracy of ECG Chest Electrode Placements by Paramedics; an observational study | Gregory, P.; Lodge, S.; Kilner, T.; Paget, S. | Pete Gregory | University of Wolverhampton | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | emergency medicine | https://www.medrxiv.org/content/early/2019/07/03/19001321.source.xml | BackgroundThe use of the 12-lead ECG is common in UK paramedic practice but its value depends upon accurate placement of the ECG-electrodes. Several studies have shown widespread variation in the placement of chest electrodes by other health professionals but no studies have addressed the accuracy of paramedics. The ma... | 10.29045/14784726.2019.12.4.3.51 | medrxiv |
10.1101/19000539 | Health workers experiences of coping with the Ebola epidemic in the Democratic Republic of the Congo health system: a qualitative study of variables of hospital activities on infection control practices in Kinshasa city | Tshima, G. K.; Kalala, K. T. | Guyguy Kabundi Tshima | Universite de Kinshasa | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/07/03/19000539.source.xml | Health workers play an important role during epidemics, but there is limited research on hospital activities on infection control practices in the Democratic Republic of the Congo and how health workers can cope during a probable health epidemic in Kinshasa city. The determinants of the current Ebola Virus Disease in t... | null | medrxiv |
10.1101/19000539 | Show solidarity with the Congolese people in the 10th Ebola outbreak declared a health emergency of international concern: understand a qualitative study of variables of hospital activities on infection control practices in Kinshasa city | Tshima, G. K.; Kalala, K. T. | Guyguy Kabundi Tshima | Universite de Kinshasa | 2019-07-23 | 2 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/07/23/19000539.source.xml | Health workers play an important role during epidemics, but there is limited research on hospital activities on infection control practices in the Democratic Republic of the Congo and how health workers can cope during a probable health epidemic in Kinshasa city. The determinants of the current Ebola Virus Disease in t... | null | medrxiv |
10.1101/19000968 | Liver function tests and fibrosis scores in a rural population in Africa: estimation of the burden of disease and associated risk factors | O'Hara, G.; Mokaya, J.; Hau, J. P.; Downs, L. O.; McNaughton, A. L.; Karabarinde, A.; Asiki, G.; Seeley, J.; Matthews, P. C.; Newton, R. | Philippa C Matthews | Nuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by | gastroenterology | https://www.medrxiv.org/content/early/2019/07/03/19000968.source.xml | IntroductionLiver disease is a major cause of morbidity and mortality in sub-Saharan Africa. However, its prevalence, distribution and aetiology have not been well characterised. We examined liver function tests (LFTs) and calculated liver fibrosis scores in a rural population in Uganda.
MethodologyA cross-sectional s... | 10.1136/bmjopen-2019-032890 | medrxiv |
10.1101/19001255 | A CALCIUM-RICH MULTI-MINERAL INTERVENTION TO MODULATE COLONIC MICROBIAL COMMUNITIES AND METABOLOMIC PROFILES IN HUMANS:Results from a 90-day trial | Aslam, M. N.; Bassis, C. M.; Bergin, I. L.; Knuver, K.; Zick, S.; Sen, A.; Turgeon, D. K.; Varani, J. | Muhammad N Aslam | University of Michigan Medical School | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | gastroenterology | https://www.medrxiv.org/content/early/2019/07/03/19001255.source.xml | Aquamin, a calcium-, magnesium-, and multiple trace element-rich natural product has polyp prevention efficacy based on preclinical studies. The overall goal of this study was to determine the safety and tolerability of Aquamin when used as a dietary chemopreventative in humans. Additionally, we determined the effects ... | 10.1158/1940-6207.CAPR-19-0325 | medrxiv |
10.1101/19000489 | Misclassification of a whole genome sequence reference defined by the Human Microbiome Project: a detrimental carryover effect to microbiome studies | Bandoy, D. D. R.; Huang, B. C.; Weimer, B. C. | Bart C Weimer | UC Davis | 2019-07-06 | 1 | PUBLISHAHEADOFPRINT | cc_no | infectious diseases | https://www.medrxiv.org/content/early/2019/07/06/19000489.source.xml | Taxonomic classification is an essential step in the analysis of microbiome data that depends on a reference database of whole genome sequences. Taxonomic classifiers are built on established reference species, such as the Human Microbiome Project database, that is growing rapidly. While constructing a population wide ... | null | medrxiv |
10.1101/19001305 | Using collaboration networks to identify authorship bias in meta-analyses | Moulin, T. C.; Amaral, O. B. | Thiago C Moulin | Uppsala University | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc | epidemiology | https://www.medrxiv.org/content/early/2019/07/08/19001305.source.xml | Meta-analytic methods are powerful resources to summarize the existing evidence concerning a given research question, and are widely used in many academic fields. However, meta-analyses can be vulnerable to various sources of bias, which should be considered to avoid inaccuracies. Many of these sources can be related t... | 10.1002/jrsm.1430 | medrxiv |
10.1101/19001305 | Using collaboration networks to identify authorship bias in meta-analyses | Moulin, T. C.; Amaral, O. B. | Thiago C Moulin | Uppsala University | 2019-12-16 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc | epidemiology | https://www.medrxiv.org/content/early/2019/12/16/19001305.source.xml | Meta-analytic methods are powerful resources to summarize the existing evidence concerning a given research question, and are widely used in many academic fields. However, meta-analyses can be vulnerable to various sources of bias, which should be considered to avoid inaccuracies. Many of these sources can be related t... | 10.1002/jrsm.1430 | medrxiv |
10.1101/19001230 | The effect of the genetic liability to autism spectrum disorder on emotion recognition in young unaffected probands from a population-based cohort | Wendt, F. R.; Muniz Carvalho, C.; Gelernter, J.; Polimanti, R. | Renato Polimanti | Yale School of Medicine | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_no | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/07/08/19001230.source.xml | We investigated how ASD genetic risk relates to neurodevelopmental features (491 traits tested) via polygenic risk scoring (PRS) in 4,309 young non-ASD probands from the Philadelphia Neurodevelopmental Cohort. ASD PRS most strongly associated with the ability to correctly identify angry facial emotions in youths aged 1... | 10.1016/j.euroneuro.2019.08.213 | medrxiv |
10.1101/19001156 | Intermittent Lactobacilli-containing Vaginal Probiotic or Metronidazole Use to Prevent Bacterial Vaginosis Recurrence: Safety and Preliminary Efficacy by Microscopy and Sequencing | van de Wijgert, J.; Verwijs, M. C.; Agaba, S. K.; Bronowski, C.; Mwambarangwe, L.; Uwineza, M.; Lievens, E.; Nivoliez, A.; Ravel, J.; Darby, A. | Janneke van de Wijgert | Institute of Infection and Global Health, University of Liverpool, Liverpool, UK | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | sexual and reproductive health | https://www.medrxiv.org/content/early/2019/07/08/19001156.source.xml | Bacterial vaginosis (BV) is associated with HIV acquisition and adverse pregnancy outcomes. Recurrence after metronidazole treatment is high. HIV-negative, non-pregnant Rwandan BV patients were randomized to four groups (n=17/group) after seven-day oral metronidazole treatment: behavioral counseling only (control), or ... | 10.1038/s41598-020-60671-6 | medrxiv |
10.1101/19001537 | Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and senile systemic amyloidoses | De Lillo, A.; De Angelis, F.; Di Girolamo, M.; Luigetti, M.; Frusconi, S.; Manfellotto, D.; Fuciarelli, M.; Polimanti, R. | Renato Polimanti | Yale University | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_no | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/07/08/19001537.source.xml | Transthyretin (TTR) gene has a causal role in a hereditary form of amyloidosis (ATTRm) and is potentially involved in the risk of senile systemic amyloidosis (SSA). To understand the genetics of ATTRm and SSA, we conducted a phenome-wide association study of TTR gene in 361,194 participants of European descent testing ... | 10.1007/s00439-019-02078-6 | medrxiv |
10.1101/19001693 | Automated interpretation of the coronary angioscopy with deep convolutional neural networks | Miyoshi, T.; Higaki, A.; Kawakami, H.; Yamaguchi, O. | Akinori Higaki | Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/07/08/19001693.source.xml | BackgroundCoronary angioscopy (CAS) is a useful modality to assess atherosclerotic changes, but interpretation of the images requires expert knowledge. Deep convolutional neural networks (DCNN) can be used for diagnostic prediction and image synthesis.
Methods107 images from 47 patients, who underwent coronary angiosc... | 10.1136/openhrt-2019-001177 | medrxiv |
10.1101/19001693 | Automated interpretation of the coronary angioscopy with deep convolutional neural networks | Miyoshi, T.; Higaki, A.; Kawakami, H.; Yamaguchi, O. | Akinori Higaki | Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada | 2019-12-17 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/12/17/19001693.source.xml | BackgroundCoronary angioscopy (CAS) is a useful modality to assess atherosclerotic changes, but interpretation of the images requires expert knowledge. Deep convolutional neural networks (DCNN) can be used for diagnostic prediction and image synthesis.
Methods107 images from 47 patients, who underwent coronary angiosc... | 10.1136/openhrt-2019-001177 | medrxiv |
10.1101/19001693 | Automated interpretation of the coronary angioscopy with deep convolutional neural networks | Miyoshi, T.; Higaki, A.; Kawakami, H.; Yamaguchi, O. | Akinori Higaki | Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada | 2020-01-08 | 3 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | cardiovascular medicine | https://www.medrxiv.org/content/early/2020/01/08/19001693.source.xml | BackgroundCoronary angioscopy (CAS) is a useful modality to assess atherosclerotic changes, but interpretation of the images requires expert knowledge. Deep convolutional neural networks (DCNN) can be used for diagnostic prediction and image synthesis.
Methods107 images from 47 patients, who underwent coronary angiosc... | 10.1136/openhrt-2019-001177 | medrxiv |
10.1101/19001545 | Bayesian spatial modelling of childhood cancer incidence in Switzerland using exact point data: A nationwide study during 1985-2015. | Konstantinoudis, G.; Schuhmacher, D.; Ammann, R.; Diesch, T.; Kuehni, C.; Spycher, B. D. | Ben Daniel Spycher | Institute of social and preventive medicine, University of Bern | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/07/08/19001545.source.xml | BackgroundThe aetiology of most childhood cancers is largely unknown. Spatially varying environmental factors such as traffic-related air pollution, background radiation and agricultural pesticides might contribute to the development of childhood cancer. We investigated the spatial variation of childhood cancers in Swi... | 10.1186/s12942-020-00211-7 | medrxiv |
10.1101/19001545 | Bayesian spatial modelling of childhood cancer incidence in Switzerland using exact point data: A nationwide study during 1985-2015. | Konstantinoudis, G.; Schuhmacher, D.; Ammann, R.; Diesch, T.; Kuehni, C.; Spycher, B. D. | Ben Daniel Spycher | Institute of social and preventive medicine, University of Bern | 2019-07-15 | 2 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/07/15/19001545.source.xml | BackgroundThe aetiology of most childhood cancers is largely unknown. Spatially varying environmental factors such as traffic-related air pollution, background radiation and agricultural pesticides might contribute to the development of childhood cancer. We investigated the spatial variation of childhood cancers in Swi... | 10.1186/s12942-020-00211-7 | medrxiv |
10.1101/19001578 | Public knowledge and attitude towards epilepsy and its associated factors in Debre Berhan, North Shoa, Amhara Region, Ethiopia, 2018/19. Community based cross sectional study | dargie, a. w.; engidaw, n. a.; basha, e. a. | abate wubetu dargie Jr. | Debre Berhan University | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/07/08/19001578.source.xml | IntroductionEpilepsy is chronic brain disorder characterized by recurrent derangement of the nervous system due to the sudden excessive disorderly discharge of the cerebral neurons. People living with epilepsy continue to suffer from enacted or perceived stigma that is based on myths, misconceptions, and misunderstandi... | null | medrxiv |
10.1101/19001578 | Public knowledge and attitude towards epilepsy and its associated factors in Debre Berhan, North Shoa, Amhara Region, Ethiopia, 2018/19. Community based cross sectional study | dargie, a. w.; engidaw, n. a.; basha, e. a. | abate wubetu dargie Jr. | Debre Berhan University | 2019-07-15 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/07/15/19001578.source.xml | IntroductionEpilepsy is chronic brain disorder characterized by recurrent derangement of the nervous system due to the sudden excessive disorderly discharge of the cerebral neurons. People living with epilepsy continue to suffer from enacted or perceived stigma that is based on myths, misconceptions, and misunderstandi... | null | medrxiv |
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