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10.1101/19001370 | FDA oversight of NSIGHT genomic research: the need for an integrated systems approach to regulation | Milko, L. V.; Chen, F.; Chan, K.; Brower, A. M.; Agrawal, P. B.; Beggs, A. H.; Berg, J. S.; Brenner, S. E.; Holm, I. A.; Koenig, B. A.; Parad, R. B.; Powell, C. M.; Kingsmore, S. F. | Stephen F Kingsmore | Rady Childrens Institute for Genomic Medicine | 2019-07-30 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | public and global health | https://www.medrxiv.org/content/early/2019/07/30/19001370.source.xml | The National Institutes of Health (NIH) funded the Newborn Sequencing In Genomic medicine and public HealTh (NSIGHT) Consortium to investigate the implications, challenges and opportunities associated with the possible use of genomic sequence information in the newborn period. Following announcement of the NSIGHT award... | 10.1038/s41525-019-0105-8 | medrxiv |
10.1101/19003269 | Individuals with Parkinson's Disease Retain Spatiotemporal Gait Control With Music and Metronome Cues | Chawla, G.; Wygand, M.; Browner, N.; Lewek, M. | Michael Lewek | UNC-Chapel Hill | 2019-07-30 | 1 | PUBLISHAHEADOFPRINT | cc_no | rehabilitation medicine and physical therapy | https://www.medrxiv.org/content/early/2019/07/30/19003269.source.xml | BackgroundParkinsons disease (PD) is marked by a loss of motor automaticity, resulting in decreased control of step length during gait. Rhythmic auditory cues (metronomes or music) may enhance automaticity by adjusting cadence. Both metronomes and music may offer distinct advantages, but prior attempts at quantifying t... | 10.1123/mc.2020-0038 | medrxiv |
10.1101/19003319 | Toric Intraocular Lens Implantation in Cataract Patients with Corneal Opacity. | Ra, H.; Kim, H. S.; Kim, M. S.; Kim, E. C. | Eun Chul Kim | Bucheon St. Mary\'s Hospital, Catholic University of Korea | 2019-07-30 | 1 | PUBLISHAHEADOFPRINT | cc_no | ophthalmology | https://www.medrxiv.org/content/early/2019/07/30/19003319.source.xml | AimsTo evaluate the effect of toric intraocular lens implantation in cataract patient with corneal opacity and high astigmatism.
Methods31 eyes of 31 patients who underwent cataract surgery with toric intraocular lens implantation were included. All patients had corneal opacity with regular astigmatism. Preoperative t... | 10.1186/s12886-020-01352-w | medrxiv |
10.1101/19002659 | Fox Insight Collects Online, Longitudinal Patient-Reported Outcomes and Genetic Data on Parkinson's Disease | Smolensky, L.; Amondikar, N.; Crawford, K.; Neu, S.; Kopil, C. M.; Daeschler, M.; Riley, L.; 23andMe Research Team, ; Brown, E.; Toga, A. W.; Tanner, C. | Luba Smolensky | The Michael J. Fox Foundation for Parkinson\'s Research | 2019-07-30 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/07/30/19002659.source.xml | Fox Insight is an online, longitudinal health study of people with and without Parkinsons disease with targeted enrollment set to at least 125,000 individuals. Fox Insight data is a rich data set facilitating discovery, validation, and reproducibility in Parkinsons disease research. The dataset is generated through rou... | 10.1038/s41597-020-0401-2 | medrxiv |
10.1101/19003525 | Incubation periods impact the spatial predictability of outbreaks: analysis of cholera and Ebola outbreaks in Sierra Leone | Kahn, R.; Peak, C. M.; Fernandez-Gracia, J.; Hill, A.; Jambai, A.; Ganda, L.; Castro, M. C.; Buckee, C. | Caroline Buckee | Harvard T.H. Chan School of Public Health | 2019-08-01 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/08/01/19003525.source.xml | Forecasting the spatiotemporal spread of infectious diseases during an outbreak is an important component of epidemic response. However, it remains challenging both methodologically and with respect to data requirements as disease spread is influenced by numerous factors, including the pathogens underlying transmission... | 10.1073/pnas.1913052117 | medrxiv |
10.1101/19003509 | Risk factors for heart failure with preserved or reduced ejection fraction among Medicare beneficiaries: Applications of completing risks analysis and gradient boosted model. | Lee, M. P.; Glynn, R. J.; Schneeweiss, S.; Lin, K. J.; Patorno, E.; Barberio, J.; Levin, R.; Evers, T.; Wang, S. V.; Desai, R. | Rishi Desai | Brigham and Women\'s Hospital and Harvard Medical School | 2019-08-01 | 1 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2019/08/01/19003509.source.xml | BackgroundThe differential impact of various demographic characteristics and comorbid conditions on development of heart failure (HF) with preserved (pEF) and reduced ejection fraction (rEF) is not well studied among the elderly.
Methods and ResultsUsing Medicare claims data linked to electronic health records, we con... | 10.2147/CLEP.S253612 | medrxiv |
10.1101/19003509 | Risk factors for heart failure with preserved or reduced ejection fraction among Medicare beneficiaries: Applications of competing risks analysis and gradient boosted model. | Lee, M. P.; Glynn, R. J.; Schneeweiss, S.; Lin, K. J.; Patorno, E.; Barberio, J.; Levin, R.; Evers, T.; Wang, S. V.; Desai, R. | Rishi Desai | Brigham and Women\'s Hospital and Harvard Medical School | 2019-09-26 | 2 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2019/09/26/19003509.source.xml | BackgroundThe differential impact of various demographic characteristics and comorbid conditions on development of heart failure (HF) with preserved (pEF) and reduced ejection fraction (rEF) is not well studied among the elderly.
Methods and ResultsUsing Medicare claims data linked to electronic health records, we con... | 10.2147/CLEP.S253612 | medrxiv |
10.1101/19002212 | Comparative functional survival and equivalent annual cost of three long lasting insecticidal net (LLIN) products in Tanzania | Lorenz, L. M.; Bradley, J.; Yukich, J.; Massue, D. J.; Mboma, Z. M.; Pigeon, O.; Moore, J. D.; Killian, A.; Lines, J.; Kisinza, W.; Overgaard, H. J.; Moore, S. J. | Sarah J Moore | Ifakara Health Institue | 2019-08-01 | 1 | PUBLISHAHEADOFPRINT | cc_by | public and global health | https://www.medrxiv.org/content/early/2019/08/01/19002212.source.xml | Almost 1.2 billion long-lasting insecticidal nets (LLINs) have been procured for malaria control. Institutional buyers often assume that World Health Organization (WHO) prequalified LLINs are functionally identical with a three-year lifespan. We measured the lifespans of three LLIN products, and calculated their cost-p... | 10.1371/journal.pmed.1003248 | medrxiv |
10.1101/19003475 | The development of competency frameworks in healthcare professions: a scoping review. | Batt, A. M.; Tavares, W.; Williams, B. | Alan M Batt | Monash University | 2019-08-01 | 1 | PUBLISHAHEADOFPRINT | cc_no | medical education | https://www.medrxiv.org/content/early/2019/08/01/19003475.source.xml | BackgroundCompetency frameworks serve various roles including outlining characteristics of a competent workforce, facilitating mobility, and analysing or assessing expertise. Given these roles and their relevance in the health professions, we sought to understand the methods and strategies used in the development of ex... | 10.1007/s10459-019-09946-w | medrxiv |
10.1101/19003475 | The development of competency frameworks in healthcare professions: a scoping review. | Batt, A. M.; Tavares, W.; Williams, B. | Alan M Batt | Monash University | 2019-11-02 | 2 | PUBLISHAHEADOFPRINT | cc_no | medical education | https://www.medrxiv.org/content/early/2019/11/02/19003475.source.xml | BackgroundCompetency frameworks serve various roles including outlining characteristics of a competent workforce, facilitating mobility, and analysing or assessing expertise. Given these roles and their relevance in the health professions, we sought to understand the methods and strategies used in the development of ex... | 10.1007/s10459-019-09946-w | medrxiv |
10.1101/19003467 | Patient Benefit and Risk in Anticancer Drug Development: A Systematic Review of the Ixabepilone Trial Portfolio | Carlisle, B. G.; Mattina, J.; Zheng, T.; Kimmelman, J. | Jonathan Kimmelman | McGill University | 2019-08-01 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc | medical ethics | https://www.medrxiv.org/content/early/2019/08/01/19003467.source.xml | OBJECTIVETo describe the patient burden and benefit, and the dynamics of trial success in the development of ixabepilone--a drug that was approved in the US but not in Europe.
DATA SOURCESTrials were captured by searching Embase and MEDLINE on July 27, 2015.
STUDY SELECTIONInclusion: 1) primary trial reports, 2) inte... | null | medrxiv |
10.1101/19003491 | Driving Me Crazy: The effects of stress on the driving abilities of paramedic students. | Hines Duncliffe, T.; D'Angelo, B.; Brock, M.; Fraser, C.; Lamarra, J.; Austin, N.; Pusateri, M.; Batt, A. M. | Alan M Batt | Fanshawe College | 2019-08-01 | 1 | PUBLISHAHEADOFPRINT | cc_by | occupational and environmental health | https://www.medrxiv.org/content/early/2019/08/01/19003491.source.xml | BackgroundPrevious research has suggested that stress may have a negative effect on the clinical performance of paramedics. In addition, stress has been demonstrated to have a negative impact the driving abilities of the general population, increasing the number of driving errors. However, to date no studies have explo... | null | medrxiv |
10.1101/19003491 | Driving Me Crazy: The effects of stress on the driving abilities of paramedic students - a pilot study. | Hines Duncliffe, T.; D'Angelo, B.; Brock, M.; Fraser, C.; Lamarra, J.; Austin, N.; Pusateri, M.; Batt, A. M. | Alan M Batt | Fanshawe College | 2019-10-10 | 2 | PUBLISHAHEADOFPRINT | cc_by | occupational and environmental health | https://www.medrxiv.org/content/early/2019/10/10/19003491.source.xml | BackgroundPrevious research has suggested that stress may have a negative effect on the clinical performance of paramedics. In addition, stress has been demonstrated to have a negative impact the driving abilities of the general population, increasing the number of driving errors. However, to date no studies have explo... | null | medrxiv |
10.1101/19003491 | The effects of stress on the driving abilities of paramedic students - a pilot, simulator-based study. | Hines Duncliffe, T.; D'Angelo, B.; Brock, M.; Fraser, C.; Lamarra, J.; Austin, N.; Pusateri, M.; Batt, A. M. | Alan M Batt | Fanshawe College | 2019-11-15 | 3 | PUBLISHAHEADOFPRINT | cc_by | occupational and environmental health | https://www.medrxiv.org/content/early/2019/11/15/19003491.source.xml | BackgroundPrevious research has suggested that stress may have a negative effect on the clinical performance of paramedics. In addition, stress has been demonstrated to have a negative impact the driving abilities of the general population, increasing the number of driving errors. However, to date no studies have explo... | null | medrxiv |
10.1101/19003202 | Changing trends in proportional incidence and 5-year net survival of screened and nonscreened invasive breast cancers among women in England | Wu, H.; Wong, K.; Lu, S.-E.; Broggio, J.; Zhang, L. | Lanjing Zhang | Princeton Medical Center/Rutgers University | 2019-08-01 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | primary care research | https://www.medrxiv.org/content/early/2019/08/01/19003202.source.xml | BackgroundUptake of breast cancer screening has been decreasing in England since 2007, and may increase proportional incidence of nonscreened cancers. However, recent trends in proportional incidence and net-survivals of screened and nonscreened breast cancers are unclear.
MethodsWe extracted population-based proporti... | 10.14218/jctp.2022.00003 | medrxiv |
10.1101/19003335 | Smoking, DNA methylation and lung function: a Mendelian randomization analysis to investigate causal relationships | Jamieson, E.; Korogolou-Linden, R.; Wootton, R.; Guyatt, A.; Battram, T.; Burrows, K.; Gaunt, T.; Tobin, M.; Munafo, M.; Davey Smith, G.; Tilling, K.; Relton, C.; Richardson, T.; Richmond, R. | Rebecca Richmond | University of Bristol | 2019-08-02 | 1 | PUBLISHAHEADOFPRINT | cc_by | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/08/02/19003335.source.xml | Whether smoking-associated DNA methylation has a causal effect on lung function has not been thoroughly evaluated. We investigated the causal effects of 474 smoking-associated CpGs on forced expiratory volume in one second (FEV1) in two-sample Mendelian randomization (MR) using methylation quantitative trait loci and g... | 10.1016/j.ajhg.2020.01.015 | medrxiv |
10.1101/19003541 | Effectiveness of four oral antifungal drugs (fluconazole, griseofulvin, itraconazole, terbinafine) in current epidemic of altered dermatophytosis in India: A randomized pragmatic trial | Singh, S.; Chandra, U.; Verma, P.; Anchan, V. N.; Tilak, R. | Sanjay Singh | Institute of Medical Sciences, Banaras Hindu University, Varanasi, India | 2019-08-02 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | dermatology | https://www.medrxiv.org/content/early/2019/08/02/19003541.source.xml | BackgroundDermatophyte infections have undergone unprecedented changes in India in recent past. Clinical trials comparing effectiveness of 4 main oral antifungal drugs are not available. We tested effectiveness of oral fluconazole, griseofulvin, itraconazole and terbinafine in chronic and chronic-relapsing tinea corpor... | 10.1111/bjd.19146 | medrxiv |
10.1101/19003558 | A phenome-wide analysis of short- and long-run disease incidence following Recurrent Pregnancy Loss using data from a 39-year period | Westergaard, D.; Nielsen, A. P.; Mortensen, L. H.; Nielsen, H. S.; Brunak, S. | Søren Brunak | University of Copenhagen | 2019-08-02 | 1 | PUBLISHAHEADOFPRINT | cc_no | obstetrics and gynecology | https://www.medrxiv.org/content/early/2019/08/02/19003558.source.xml | BackgroundPregnancy loss is one of the most frequent pregnancy complications. It is unclear how recurrent pregnancy loss (RPL) impacts disease risk later in life and if later disease risk is different in women with or without a live birth prior to RPL (primary vs. secondary RPL). We sought to investigate if women have ... | 10.1161/JAHA.119.015069 | medrxiv |
10.1101/19003665 | Eating behavior trajectories in the first ten years of life and their relationship with BMI | Herle, M.; De Stavola, B.; Huebel, C.; Santos Ferreira, D.; Abdulkadir, M.; Yilmaz, Z.; Loos, R.; Bryant-Waugh, R.; Bulik, C.; Micali, N. | Nadia Micali | University College London | 2019-08-02 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | pediatrics | https://www.medrxiv.org/content/early/2019/08/02/19003665.source.xml | BackgroundChild eating behaviors are highly heterogeneous and their longitudinal impact on childhood weight is unclear. The objective of this study was to characterize eating behaviors during the first ten years of life and evaluate associations with BMI at age 11 years.
MethodData were parental reports of eating beha... | 10.1038/s41366-020-0581-z | medrxiv |
10.1101/19003665 | Eating behavior trajectories in the first ten years of life and their relationship with BMI | Herle, M.; De Stavola, B.; Huebel, C.; Santos Ferreira, D.; Abdulkadir, M.; Yilmaz, Z.; Loos, R.; Bryant-Waugh, R.; Bulik, C.; Micali, N. | Nadia Micali | University College London | 2020-01-09 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | pediatrics | https://www.medrxiv.org/content/early/2020/01/09/19003665.source.xml | BackgroundChild eating behaviors are highly heterogeneous and their longitudinal impact on childhood weight is unclear. The objective of this study was to characterize eating behaviors during the first ten years of life and evaluate associations with BMI at age 11 years.
MethodData were parental reports of eating beha... | 10.1038/s41366-020-0581-z | medrxiv |
10.1101/19003798 | Characteristics of Patients that Substitute Medical Cannabis for Alcohol | Hayat, A.; Piper, B. J. | Brian James Piper | Geisinger Commonwealth School of Medicine | 2019-08-02 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | pharmacology and therapeutics | https://www.medrxiv.org/content/early/2019/08/02/19003798.source.xml | AimsA substitution effect occurs when patients substitute Medical Cannabis (MC) for another drug. Over three-quarters (76.7%) of New England dispensary members reported reducing their use of opioids and two-fifths (42.0%) decreased their use of alcohol after starting MC (Piper et al. 2017). The objective of this explor... | 10.1080/02791072.2019.1694199 | medrxiv |
10.1101/19003749 | Role of miRNAs induced by oxidized low-density lipoproteins in coronary artery disease: the REGICOR Study. | Degano, I. R.; Subirana, I.; Garcia-Mateo, N.; Cidad, P.; Munoz-Aguayo, D.; Puigdecanet, E.; Nonell, L.; Vila, J.; Camps, A.; Crepaldi, F.; de Gonzalo-Calvo, D.; Llorente-Cortes, V.; Perez-Garcia, M. T.; Elosua, R.; Fito, M.; Marrugat, J. | Jaume Marrugat | Hospital del Mar Medical Research Institute, Barcelona, Spain | 2019-08-02 | 1 | PUBLISHAHEADOFPRINT | cc_no | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/08/02/19003749.source.xml | AimsCurrent risk prediction tools are not accurate enough to identify most individuals at high coronary risk. On the other hand, oxidized low-density lipoproteins (ox-LDLs) and miRNAs are actively involved in atherosclerosis. Our aim was to examine the association of ox-LDL-induced miRNAs with coronary artery disease (... | 10.3390/jcm9051402 | medrxiv |
10.1101/19003822 | Meat intake and cancer risk: prospective analyses in UK Biobank | Knuppel, A.; Papier, K.; Fensom, G. K.; Appleby, P. N.; Schmidt, J. A.; Tong, T. Y. N.; Travis, R. C.; Key, T. J.; Perez-Cornago, A. | Anika Knuppel | Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford | 2019-08-02 | 1 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2019/08/02/19003822.source.xml | BackgroundRed and processed meat has been consistently associated with risk for colorectal cancer, but evidence for other cancer sites is limited and few studies have examined the association between poultry intake and cancer risk. We examined associations between total meat, red meat, processed meat and poultry intake... | 10.1093/ije/dyaa142 | medrxiv |
10.1101/19002998 | Validation of Serum Neurofilaments as Prognostic & Potential Pharmacodynamic Biomarkers for ALS | Benatar, M.; Zhang, L.; Wang, L.; Granit, V.; Statland, J.; Barohn, R. J.; Swenson, A.; Ravits, J.; Jackson, C.; Burns, T. M.; Trivedi, J.; Pioro, E. P.; Caress, J.; Katz, J.; McCauley, J. L.; Rademakers, R.; Malaspina, A.; Ostrow, L. W.; Wuu, J.; CReATe Consortium, | Michael Benatar | University of Miami | 2019-08-03 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | neurology | https://www.medrxiv.org/content/early/2019/08/03/19002998.source.xml | ObjectiveIdentify preferred neurofilament assays, and clinically validate serum NfL and pNfH as prognostic and potential pharmacodynamic biomarkers relevant to ALS therapy development.
MethodsProspective, multi-center, longitudinal observational study of patients with ALS (n=229), primary lateral sclerosis (PLS, n=20)... | 10.1212/WNL.0000000000009559 | medrxiv |
10.1101/19002998 | Validation of Serum Neurofilaments as Prognostic & Potential Pharmacodynamic Biomarkers for ALS | Benatar, M.; Zhang, L.; Wang, L.; Granit, V.; Statland, J.; Barohn, R. J.; Swenson, A.; Ravits, J.; Jackson, C.; Burns, T. M.; Trivedi, J.; Pioro, E. P.; Caress, J.; Katz, J.; McCauley, J. L.; Rademakers, R.; Malaspina, A.; Ostrow, L. W.; Wuu, J.; CReATe Consortium, | Michael Benatar | University of Miami | 2019-10-10 | 2 | PUBLISHAHEADOFPRINT | cc_by_nd | neurology | https://www.medrxiv.org/content/early/2019/10/10/19002998.source.xml | ObjectiveIdentify preferred neurofilament assays, and clinically validate serum NfL and pNfH as prognostic and potential pharmacodynamic biomarkers relevant to ALS therapy development.
MethodsProspective, multi-center, longitudinal observational study of patients with ALS (n=229), primary lateral sclerosis (PLS, n=20)... | 10.1212/WNL.0000000000009559 | medrxiv |
10.1101/19003012 | Improvements in the incidence and survival of cancer and cardiovascular but not infectious disease have driven recent mortality improvements in Scotland: nationwide cohort study of linked hospital admission and death records 2001-2016 | Timmers, P. R. H. J.; Kerssens, J. J.; Minton, J. W.; Grant, I.; Wilson, J. F.; Campbell, H.; Fischbacher, C. M.; Joshi, P. K. | Paul R. H. J. Timmers | Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK | 2019-08-05 | 1 | PUBLISHAHEADOFPRINT | cc_by | public and global health | https://www.medrxiv.org/content/early/2019/08/05/19003012.source.xml | ObjectivesTo identify the causes and future trends underpinning improvements in life expectancy in Scotland and quantify the relative contributions of disease incidence and survival.
DesignPopulation-based study.
SettingLinked secondary care and mortality records across Scotland.
Participants1,967,130 individuals bo... | 10.1136/bmjopen-2019-034299 | medrxiv |
10.1101/19001214 | Mental Health in UK Biobank Revised | Davis, K. A. S.; Coleman, J. R. I.; Adams, M.; Allen, N.; Breen, G.; Cullen, B.; Dickens, C. M.; Fox, E.; Graham, N.; Holliday, J.; Howard, L. M.; John, A.; Lee, W.; McCabe, R.; McIntosh, A. M.; Pearsall, R.; Smith, D. J.; Sudlow, C.; Ward, J.; Zammit, S.; Hotopf, M. | Matthew Hotopf | KCL Institute of Psychiatry Psychology and Neuroscience and UK Biobank | 2019-08-05 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/08/05/19001214.source.xml | This paper corrects and updates a paper published in BJPsych Open 2018 "Mental Health in UK Biobank" (https://doi.org/10.1192/bjo.2018.12) that was voluntarily retracted following the finding of errors in the coding of the variable for alcohol use disorder. Notably, the percentage of participants reaching threshold for... | 10.1192/bjo.2019.100 | medrxiv |
10.1101/19003483 | Investigating the attitudes of Canadian paramedic students towards homelessness. | Cochrane, A.; Pithia, P.; Laird, E.; Mifflin, K.; Sonley-Long, V.; Batt, A. M. | Alan M Batt | Fanshawe College | 2019-08-06 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | public and global health | https://www.medrxiv.org/content/early/2019/08/06/19003483.source.xml | IntroductionWhen paramedics are dispatched, it is expected that every patient receives the same level of care regardless of variable factors. Homelessness is a growing social issue across Canada that is particularly prevalent in urban areas. The quality of healthcare delivered to individuals experiencing homelessness m... | null | medrxiv |
10.1101/19004069 | Enhanced mindfulness based stress reduction (MBSR+) in episodic migraine: a randomized clinical trial with MRI outcomes | Seminowicz, D. A.; Burrowes, S.; Kearson, A.; Zhang, J.; Krimmel, S.; Samawi, L.; Furman, A.; Keaser, M.; Gould, N.; Magyari, T.; White, L.; Goloubeva, O.; Goyal, M.; Peterlin, L.; Haythornthwaite, J. | David A Seminowicz | University of Maryland Baltimore | 2019-08-06 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | pain medicine | https://www.medrxiv.org/content/early/2019/08/06/19004069.source.xml | We aimed to evaluate the efficacy of an enhanced mindfulness based stress reduction (MBSR+) versus stress management for headache (SMH). We performed a randomized, assessor-blind, clinical trial of 98 adults with episodic migraine recruited at a single academic center comparing MBSR+ (n=50) to SMH (n=48). MBSR+ and SMH... | 10.1097/j.pain.0000000000001860 | medrxiv |
10.1101/19004069 | Enhanced mindfulness based stress reduction (MBSR+) in episodic migraine: a randomized clinical trial with MRI outcomes | Seminowicz, D. A.; Burrowes, S.; Kearson, A.; Zhang, J.; Krimmel, S.; Samawi, L.; Furman, A.; Keaser, M.; Gould, N.; Magyari, T.; White, L.; Goloubeva, O.; Goyal, M.; Peterlin, L.; Haythornthwaite, J. | David A Seminowicz | University of Maryland Baltimore | 2020-02-07 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | pain medicine | https://www.medrxiv.org/content/early/2020/02/07/19004069.source.xml | We aimed to evaluate the efficacy of an enhanced mindfulness based stress reduction (MBSR+) versus stress management for headache (SMH). We performed a randomized, assessor-blind, clinical trial of 98 adults with episodic migraine recruited at a single academic center comparing MBSR+ (n=50) to SMH (n=48). MBSR+ and SMH... | 10.1097/j.pain.0000000000001860 | medrxiv |
10.1101/19004234 | Time to death and its Predictors among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia | Wondimu, W.; Kabeta, T.; Dube, L. | Wondimagegn Wondimu | Mizan Tepi University | 2019-08-07 | 1 | PUBLISHAHEADOFPRINT | cc_no | hiv aids | https://www.medrxiv.org/content/early/2019/08/07/19004234.source.xml | BackgroundTuberculosis (TB) and Human Immuno Deficiency Virus (HIV) co-infection represents a complex pathogenic scenario with synergistic effect and leads to about 300,000 HIV-associated TB deaths in the world in 2017. Despite this burden of death, time to death and its predictors among TB-HIV co-infected patient was ... | 10.2147/HIV.S242756 | medrxiv |
10.1101/19004309 | Self-blaming emotions in major depression: a randomised pilot trial comparing fMRI neurofeedback training with self-guided psychological strategies (NeuroMooD) | Jaeckle, T.; Williams, S. C. R.; Barker, G. J.; Basilio, R.; Carr, E.; Goldsmith, K.; Colasanti, A.; Giampietro, V.; Cleare, A.; Young, A. H.; Moll, J.; Zahn, R. | Roland Zahn | King\'s College London | 2019-08-09 | 1 | PUBLISHAHEADOFPRINT | cc_no | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/08/09/19004309.source.xml | BackgroundOvergeneralised self-blame and worthlessness are key symptoms of major depressive disorder (MDD) and were previously associated with self-blame-selective changes in connectivity between right superior anterior temporal lobe (rSATL) and subgenual frontal areas. In a previous study, remitted MDD patients succes... | 10.1017/s0033291721004797 | medrxiv |
10.1101/19003251 | The Effects of Metronome Frequency Differentially Affects Gait on a Treadmill and Overground in People with Parkinson's Disease | Wygand, M.; Chawla, G.; Browner, N.; Lewek, M. | Michael Lewek | UNC-Chapel Hill | 2019-08-09 | 1 | PUBLISHAHEADOFPRINT | cc_no | rehabilitation medicine and physical therapy | https://www.medrxiv.org/content/early/2019/08/09/19003251.source.xml | ObjectiveTo determine the effect of different metronome cue frequencies on spatiotemporal gait parameters when walking overground compared to walking on a treadmill in people with Parkinsons disease
DesignRepeated-measures, within-subject design
SettingResearch laboratory
ParticipantsTwenty-one people with Parkinson... | 10.1016/j.gaitpost.2020.04.003 | medrxiv |
10.1101/19002535 | Comparison of student perception and exam validity, reliability and items difficulty: cross-sectional study. | Rezigalla, A. A.; Eleragi, A. M. E.; Elkhalifa, M. I.; Mohammed, A. M. A. | Assad Ali Rezigalla | Department of Basic medical sciences, College of Medicine, University of Bisha, Bisha 61922, P.O. Box 551, Saudi Arabia. | 2019-08-09 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | medical education | https://www.medrxiv.org/content/early/2019/08/09/19002535.source.xml | IntroductionStudent perception of an exam is a reflection of their feelings towards the exam items, while item analysis is a statistical analysis of students responses to exam items. The study was formulated to compare the students perception of the results of item analysis.
Material and methodsType of the study is cr... | 10.18502/sjms.v15i2.5503 | medrxiv |
10.1101/19002949 | Association between the ACE I/D gene polymorphism and progressive renal failure in autosomal dominant polycystic kidney disease: A meta-analysis | Pabalan, N.; Tharabenjasin, P.; Parcharoen, Y.; Tasanarong, A. | Noel Pabalan | Thammasat University | 2019-08-09 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | nephrology | https://www.medrxiv.org/content/early/2019/08/09/19002949.source.xml | ObjectiveThe angiotensin converting enzyme insertion/deletion (ACE I/D) gene polymorphism is involved in a wide range of clinical outcomes. This makes ACE I/D an important genetic marker. Updating the genetic profile of ACE I/D and raising the evidence for its role in renal disease is therefore needed. Reported associa... | null | medrxiv |
10.1101/19001032 | Identifying Ashkenazi Jewish BRCA1/2 founder variants in individuals who do not self-report Jewish ancestry | Tennen, R. I.; Laskey, S. B.; Koelsch, B. L.; McIntyre, M. H.; The 23andMe Health Team, ; Tung, J. Y. | Joyce Y Tung | 23andMe | 2019-08-09 | 1 | PUBLISHAHEADOFPRINT | cc_by | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/08/09/19001032.source.xml | Current guidelines recommend BRCA1 and BRCA2 genetic testing for individuals with a personal or family history of certain cancers. Three BRCA1/2 founder variants -- 185delAG (c.68_69delAG), 5382insC (c.5266dupC), and 6174delT (c.5946delT) -- are common in the Ashkenazi Jewish population. We characterized a cohort of mo... | 10.1038/s41598-020-63466-x | medrxiv |
10.1101/19003087 | Host genetic variants near the PAX5 gene locus associate with susceptibility to invasive group A streptococcal disease | Parks, T.; Auckland, K.; Lamagni, T. L.; Mentzer, A. J.; Elliott, K.; Guy, R.; Cartledge, D.; Strakova, L.; O'Connor, D.; Pollard, A. J.; Chapman, S. J.; Thomas, M.; Brodlie, M.; Colot, J.; D'Ortenzio, E.; Baroux, N.; Mirabel, M.; Gilchrist, J. J.; Scott, J. A. G.; Williams, T. N.; Knight, J. C.; Steer, A. C.; Hill, A.... | Tom Parks | University of Oxford | 2019-08-09 | 1 | PUBLISHAHEADOFPRINT | cc_by | infectious diseases | https://www.medrxiv.org/content/early/2019/08/09/19003087.source.xml | We undertook a genome-wide association study of susceptibility to invasive group A streptococcal (GAS) disease combining data from distinct clinical manifestations and ancestral populations. Amongst other signals, we identified a susceptibility locus located 18kb from PAX5, an essential B-cell gene, which conferred a n... | null | medrxiv |
10.1101/19003376 | Increasing Heroin, Cocaine, and Buprenorphine Arrests Reported to the Maine Diversion Alert Program | Simpson, K. J.; Moran, M. T.; McCall, K. L.; Hebert, J.; Foster, M.; Simoyan, O.; Shah, D. T.; Desrosiers, C.; Nichols, S. D.; Piper, B. J. | Brian James Piper | Geisinger Commonwealth School of Medicine | 2019-08-09 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | addiction medicine | https://www.medrxiv.org/content/early/2019/08/09/19003376.source.xml | BackgroundThe opioid overdose crisis is especially pronounced in Maine. The Diversion Alert Program (DAP) was developed to combat illicit drug use and prescription drug diversion by facilitating communication between law enforcement and healthcare providers with the goal of limiting drug-related harms and criminal beha... | 10.1016/j.forsciint.2019.109924 | medrxiv |
10.1101/19004382 | Elevated blood pressure in the emergency department - a risk factor for incident cardiovascular disease: An EHR-based cohort study | Oras, P.; Habel, H.; Skoglund, P.; Svensson, P. | Pontus Oras | Department of Clinical Science and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden | 2019-08-10 | 1 | PUBLISHAHEADOFPRINT | cc_no | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/08/10/19004382.source.xml | ObjectivesIn the emergency department (ED), high blood pressure (BP) is commonly observed but mostly used to evaluate patients health in the short-term. We aimed to study whether ED-measured BP is associated with incident atherosclerotic cardiovascular disease (ASCVD), myocardial infarction (MI), or stroke in long-term... | 10.1161/hypertensionaha.119.14002 | medrxiv |
10.1101/19004242 | Causal mediation analysis of Subclinical Hypothyroidism in children with obesity and Non-Alcoholic Fatty Liver Disease | Nichols, P.; Pan, Y.; May, B.; Pavlicova, M.; Mencin, A.; Thaker, V. V. | Vidhu V Thaker | Columbia University Irving Medical Center | 2019-08-10 | 1 | PUBLISHAHEADOFPRINT | cc_no | pediatrics | https://www.medrxiv.org/content/early/2019/08/10/19004242.source.xml | ContextNonalcoholic Fatty Liver Disease (NAFLD) is a common co-morbidity of obesity and a leading cause of liver disease in children. Subclinical hypothyroidism (SH) occurs with obesity and may contribute to dysmetabolic state that predisposes to NAFLD.
ObjectiveTo assess the relationship between SH and NAFLD in child... | 10.1371/journal.pone.0234985 | medrxiv |
10.1101/19004242 | Causal mediation analysis of Subclinical Hypothyroidism in children with obesity and Non-Alcoholic Fatty Liver Disease | Nichols, P.; Pan, Y.; May, B.; Pavlicova, M.; Rausch, J.; Mencin, A.; Thaker, V. V. | Vidhu V Thaker | Columbia University Irving Medical Center | 2019-11-26 | 2 | PUBLISHAHEADOFPRINT | cc_no | pediatrics | https://www.medrxiv.org/content/early/2019/11/26/19004242.source.xml | ContextNonalcoholic Fatty Liver Disease (NAFLD) is a common co-morbidity of obesity and a leading cause of liver disease in children. Subclinical hypothyroidism (SH) occurs with obesity and may contribute to dysmetabolic state that predisposes to NAFLD.
ObjectiveTo assess the relationship between SH and NAFLD in child... | 10.1371/journal.pone.0234985 | medrxiv |
10.1101/19004432 | Identifying barriers and facilitators to physical activity for people with scleroderma: A nominal group technique study | Harb, S.; Cumin, J.; Rice, D. B.; Pelaez, S.; Hudson, M.; Bartlett, S. J.; Roren, A.; Furst, D. E.; Frech, T. M.; Nguyen, C.; Nielson, W. R.; Thombs, B. D.; Shrier, I.; Patient Advisory Team, S.-P. | Ian Shrier | Lady Davis Institute for Medical Research, Jewish General Hospital | 2019-08-11 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | rheumatology | https://www.medrxiv.org/content/early/2019/08/11/19004432.source.xml | PurposeTo identify physical activity barriers and facilitators experienced by people with systemic sclerosis (SSc; scleroderma).
Materials and MethodsWe conducted nominal group technique sessions with SSc patients who shared barriers to physical activities, barrier-specific facilitators, and general facilitators. Part... | 10.1080/09638288.2020.1742391 | medrxiv |
10.1101/19003194 | Insomnia, excessive daytime sleepiness, anxiety, depression and socioeconomic status among customer service employees in Canada | Etindele Sosso, F. | FA Etindele Sosso | Center for Advanced Research in Sleep Medicine | 2019-08-12 | 1 | PUBLISHAHEADOFPRINT | cc_by | occupational and environmental health | https://www.medrxiv.org/content/early/2019/08/12/19003194.source.xml | ObjectivesThe present study alerts on the potential effect of working full time in a call center as a risk factor for neuropsychiatric illnesses. It is the first study investigating deeply presence of anxiety, depression, insomnia and excessive daytime sleepiness among a large population of customer service employees. ... | 10.5935/1984-0063.20190133 | medrxiv |
10.1101/19004333 | Immunoglobulin E as a biomarker for the overlap of atopic asthma and chronic obstructive pulmonary disease | Hersh, C. P.; Zacharia, S.; Prakash Arivu Chelvan, R.; Hayden, L. P.; Mirtar, A.; Zarei, S.; Putcha, N.; the COPDGene Investigators, | Craig P Hersh | Brigham and Women\'s Hospital | 2019-08-12 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | respiratory medicine | https://www.medrxiv.org/content/early/2019/08/12/19004333.source.xml | Asthma-COPD overlap (ACO) is a common clinical syndrome, yet there is no single objective definition. We hypothesized that Immunoglobulin E measurements could be used to refine the definition of ACO. In baseline plasma samples from 2870 subjects in the COPDGene Study, we measured total IgE levels and specific IgE level... | 10.15326/jcopdf.7.1.2019.0138 | medrxiv |
10.1101/19001727 | Transcriptional survey of peripheral blood links lower oxygen saturation during sleep with reduced expressions of CD1D and RAB20 that is reversed by CPAP therapy | Sofer, T.; Li, R.; Joehanes, R.; Lin, H.; Gower, A. C.; Wang, H.; Kurniansyah, N.; Cade, B. E.; Li, J.; Williams, S.; Mehra, R.; Patel, S. R.; Quan, S. F.; Liu, Y.; Rotter, J. I.; Rich, S. S.; Spira, A.; Levy, D.; Gharib, S. A.; Redline, S.; Gottlieb, D. J. | Tamar Sofer | Harvard Medical School, Brigham and Women\'s Hospital | 2019-08-12 | 1 | PUBLISHAHEADOFPRINT | cc_no | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/08/12/19001727.source.xml | Sleep Disordered Breathing (SDB) is associated with a wide range of physiological changes due, in part, to the influence of hypoxemia during sleep. We studied gene expression in peripheral blood mononuclear cells in association with three measures of SDB: Apnea Hypopnea Index (AHI); average oxyhemoglobin saturation (av... | 10.1016/j.ebiom.2020.102803 | medrxiv |
10.1101/19003780 | A flexible formula for incorporating distributive concerns into cost-effectiveness analyses: priority weights | Haaland, O. A.; Lindemark, F.; Johansson, K. A. | Øystein Ariansen Haaland | Bergen center for ethics and priority setting (BCEPS), Department of global public health and primary care, University of Bergen, Norway | 2019-08-12 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | health economics | https://www.medrxiv.org/content/early/2019/08/12/19003780.source.xml | Cost effectiveness analyses (CEAs) are widely used to evaluate the opportunity cost of health care investments. However, few functions that take equity concerns into account are available for such CEA methods, and these concerns are therefore at risk of being disregarded. Among the functions that have been developed, m... | 10.1371/journal.pone.0223866 | medrxiv |
10.1101/19003533 | Examining Gender Differences in Opioid, Benzodiazepine, and Antibiotic Prescribing | Hamamsy, T.; Tamang, S.; Lembke, A. | Tymor Hamamsy | New York University | 2019-08-12 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | health informatics | https://www.medrxiv.org/content/early/2019/08/12/19003533.source.xml | While gender differences have been explored across several areas of medicine, our study is the first to present a systematic comparison of drug prescribing behavior of male and female providers, including opioid, benzodiazepine, and antibiotic prescribing. Our work is of particular relevance to the current opioid crisi... | null | medrxiv |
10.1101/19003871 | Does the early nutritional environment and in utero HIV exposure, in the absence of infant infection, impact infant development? | White, M.; Duffley, E.; Feucht, U. D.; Rossouw, T.; Connor, K. L. | Kristin L Connor | Department of Health Sciences, Carleton University | 2019-08-12 | 1 | PUBLISHAHEADOFPRINT | cc_no | hiv aids | https://www.medrxiv.org/content/early/2019/08/12/19003871.source.xml | Malnutrition and infectious disease often coexist in socially inequitable contexts. Malnutrition in the perinatal period adversely affects offspring development and lifelong non-communicable disease risk. Less is known about the effects of infectious disease exposure during critical windows of development and health, a... | null | medrxiv |
10.1101/19003871 | How do maternal HIV infection and the early nutritional environment influence the development of infants exposed to HIV in utero? | White, M.; Duffley, E.; Feucht, U. D.; Rossouw, T.; Connor, K. L. | Kristin L Connor | Department of Health Sciences, Carleton University | 2019-09-14 | 2 | PUBLISHAHEADOFPRINT | cc_no | hiv aids | https://www.medrxiv.org/content/early/2019/09/14/19003871.source.xml | Malnutrition and infectious disease often coexist in socially inequitable contexts. Malnutrition in the perinatal period adversely affects offspring development and lifelong non-communicable disease risk. Less is known about the effects of infectious disease exposure during critical windows of development and health, a... | null | medrxiv |
10.1101/19003616 | Depletion-of-susceptibles bias in influenza vaccine waning studies: how to ensure robust results | Lipsitch, M.; Goldstein, E. M.; Ray, G. T.; Fireman, B. | Marc Lipsitch | Harvard Chan School of Public Health | 2019-08-12 | 1 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/08/12/19003616.source.xml | Vaccine effectiveness (VE) studies are subject to biases due to depletion of at-risk persons or of highly susceptible persons at different rates from different groups (depletion-of-susceptibles bias), a problem that can also lead to biased estimates of waning effectiveness, including spurious inference of waning when n... | 10.1017/S0950268819001961 | medrxiv |
10.1101/19003657 | Impact of pediatric influenza vaccination on antibiotic resistance in England and Wales | Chae, C.; Davies, N. G.; Jit, M.; Atkins, K. E. | Nicholas G Davies | London School of Hygiene and Tropical Medicine | 2019-08-12 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/08/12/19003657.source.xml | Vaccines against viral infections have been proposed to reduce antibiotic prescribing and thereby help control resistant bacterial infections. However, by combining published data sources, we predict that pediatric live attenuated influenza vaccination in England and Wales will not have a major impact upon antibiotic c... | 10.3201/eid2601.191110 | medrxiv |
10.1101/19003772 | Associations of childcare type, age at start, and intensity with body mass index trajectories from 10 to 42 years of age in the 1970 British Cohort Study | Costa, S.; Bann, D.; Benjamin-Neelon, S. E.; Adams, J.; Johnson, W. | Silvia Costa | Loughborough University | 2019-08-12 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/08/12/19003772.source.xml | BackgroundAttending childcare is related to greater childhood obesity risk, but there are few long-term follow-up studies. We aimed to examine the associations of childcare type, duration, and intensity with BMI trajectories from ages 10-42 years.
MethodsThe sample comprised 8234 individuals in the 1970 British Cohort... | 10.1111/ijpo.12644 | medrxiv |
10.1101/19003061 | Prevalence of diabetic foot ulcer and its association with duration of illness and residence in Ethiopia: a systematic review and meta-analysis. | Mulugeta, H.; Wagnew, F.; Zeleke, H.; Tesfaye, B.; Amha, H.; Leshargie, C. T.; Biresaw, H.; Dessie, G.; Belay, Y. A.; Habtewold, T. D. | Henok Mulugeta | Debre Markos University | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | endocrinology | https://www.medrxiv.org/content/early/2019/08/13/19003061.source.xml | BackgroundDiabetic foot ulcer (DFU), devastating complications of diabetes mellitus, is a major public health problem, and one of the leading reasons for hospital admission, amputations, and even death among diabetic patients in Ethiopia. Despite its catastrophic health consequences, the national burden of diabetic foo... | null | medrxiv |
10.1101/19004705 | Generalisability of Results from UK Biobank: Comparison With a Pooling of 18 Cohort Studies | Batty, G. D.; Gale, C.; Kivimaki, M.; Deary, I.; Bell, S. | George David Batty | University College London | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2019/08/13/19004705.source.xml | BackgroundThe UK Biobank cohort study has become a much-utilised and influential scientific resource. With a primary goal of understanding disease aetiology, the low response to the original survey of 5.5% has, however, led to debate as to the generalisability of these findings. We therefore compared risk factor-diseas... | null | medrxiv |
10.1101/19004317 | Efficient prediction of vitamin B deficiencies via machine-learning using routine blood test results in patients with intense psychiatric episode | Tamune, H.; Ukita, J.; Hamamoto, Y.; Tanaka, H.; Narushima, K.; Yamamoto, N. | Hidetaka Tamune | Department of Neuropsychiatry, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/08/13/19004317.source.xml | BackgroundVitamin B deficiency is common worldwide and may lead to psychiatric symptoms; however, vitamin B deficiency epidemiology in patients with intense psychiatric episode has rarely been examined. Moreover, vitamin deficiency testing is costly and time-consuming. It hampered to effectively rule out vitamin defici... | 10.3389/fpsyt.2019.01029 | medrxiv |
10.1101/19004317 | Efficient prediction of vitamin B deficiencies via machine-learning using routine blood test results in patients with intense psychiatric episode | Tamune, H.; Ukita, J.; Hamamoto, Y.; Tanaka, H.; Narushima, K.; Yamamoto, N. | Hidetaka Tamune | Department of Neuropsychiatry, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan | 2019-11-13 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/11/13/19004317.source.xml | BackgroundVitamin B deficiency is common worldwide and may lead to psychiatric symptoms; however, vitamin B deficiency epidemiology in patients with intense psychiatric episode has rarely been examined. Moreover, vitamin deficiency testing is costly and time-consuming. It hampered to effectively rule out vitamin defici... | 10.3389/fpsyt.2019.01029 | medrxiv |
10.1101/19003426 | Efficacy of a spatial repellent for control of malaria in Indonesia: a cluster-randomized controlled trial. | Syafruddin, D.; Asih, P. B.; Rozi, I. E.; Permana, D. H.; Hidayati, A. P. N.; Syahrani, L.; Zubaidah, S.; Sidik, D.; Bangs, M. J.; Bogh, C.; Liu, F.; Eugenio, E. C.; Hendrickson, J.; Burton, T. A.; Baird, J. K.; Collins, F. H.; Grieco, J. P.; Lobo, N. F.; Achee, N. L. | Nicole L Achee | Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, USA | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | public and global health | https://www.medrxiv.org/content/early/2019/08/13/19003426.source.xml | A cluster randomized, double-blinded, placebo-controlled trial was conducted to estimate protective efficacy of a spatial repellent against malaria infection at Sumba, Indonesia. Following radical cure in 1,341 children aged [≥] 6 months - [≤]5 years in 24 clusters, households were given transfluthrin or placebo ... | 10.4269/ajtmh.19-0554 | medrxiv |
10.1101/19003426 | Efficacy of a spatial repellent for control of malaria in Indonesia: a cluster-randomized controlled trial. | Syafruddin, D.; Asih, P. B.; Rozi, I. E.; Permana, D. H.; Hidayati, A. P. N.; Syahrani, L.; Zubaidah, S.; Sidik, D.; Bangs, M. J.; Bogh, C.; Liu, F.; Eugenio, E. C.; Hendrickson, J.; Burton, T. A.; Baird, J. K.; Collins, F. H.; Grieco, J. P.; Lobo, N. F.; Achee, N. L. | Nicole L Achee | Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, USA | 2019-08-31 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | public and global health | https://www.medrxiv.org/content/early/2019/08/31/19003426.source.xml | A cluster randomized, double-blinded, placebo-controlled trial was conducted to estimate protective efficacy of a spatial repellent against malaria infection at Sumba, Indonesia. Following radical cure in 1,341 children aged [≥] 6 months - [≤]5 years in 24 clusters, households were given transfluthrin or placebo ... | 10.4269/ajtmh.19-0554 | medrxiv |
10.1101/19003426 | Efficacy of a spatial repellent for control of malaria in Indonesia: a cluster-randomized controlled trial. | Syafruddin, D.; Asih, P. B.; Rozi, I. E.; Permana, D. H.; Hidayati, A. P. N.; Syahrani, L.; Zubaidah, S.; Sidik, D.; Bangs, M. J.; Bogh, C.; Liu, F.; Eugenio, E. C.; Hendrickson, J.; Burton, T. A.; Baird, J. K.; Collins, F. H.; Grieco, J. P.; Lobo, N. F.; Achee, N. L. | Nicole L Achee | Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, USA | 2019-11-05 | 3 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | public and global health | https://www.medrxiv.org/content/early/2019/11/05/19003426.source.xml | A cluster randomized, double-blinded, placebo-controlled trial was conducted to estimate protective efficacy of a spatial repellent against malaria infection at Sumba, Indonesia. Following radical cure in 1,341 children aged [≥] 6 months - [≤]5 years in 24 clusters, households were given transfluthrin or placebo ... | 10.4269/ajtmh.19-0554 | medrxiv |
10.1101/19003426 | Efficacy of a spatial repellent for control of malaria in Indonesia: a cluster-randomized controlled trial. | Syafruddin, D.; Asih, P. B.; Rozi, I. E.; Permana, D. H.; Hidayati, A. P. N.; Syahrani, L.; Zubaidah, S.; Sidik, D.; Bangs, M. J.; Bogh, C.; Liu, F.; Eugenio, E. C.; Hendrickson, J.; Burton, T. A.; Baird, J. K.; Collins, F. H.; Grieco, J. P.; Lobo, N. F.; Achee, N. L. | Nicole L Achee | Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, USA | 2020-03-29 | 4 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | public and global health | https://www.medrxiv.org/content/early/2020/03/29/19003426.source.xml | A cluster randomized, double-blinded, placebo-controlled trial was conducted to estimate protective efficacy of a spatial repellent against malaria infection at Sumba, Indonesia. Following radical cure in 1,341 children aged [≥] 6 months - [≤]5 years in 24 clusters, households were given transfluthrin or placebo ... | 10.4269/ajtmh.19-0554 | medrxiv |
10.1101/19004259 | Applications of qualitative grounded theory methodology to investigate hearing loss: Protocol for a qualitative systematic review | Ali, Y. H. K.; Wright, N.; Charnock, D.; Henshaw, H.; Ferguson, M. A.; Hoare, D. J. | Yasmin H.K. Ali | National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, University of Nottingham | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | otolaryngology | https://www.medrxiv.org/content/early/2019/08/13/19004259.source.xml | ABTRACTO_ST_ABSIntroductionC_ST_ABSHearing loss is a chronic condition affecting 11 million individuals in the UK. People with hearing loss regularly experience difficulties interacting in everyday conversations. These difficulties in communication can result in a person with hearing loss withdrawing from social situat... | 10.1136/bmjopen-2019-033537 | medrxiv |
10.1101/19004598 | Accuracy of Medical Billing Data Against the Electronic Health Record in the Measurement of Colorectal Cancer Screening Rates | Rudrapatna, V. A.; Glicksberg, B. S.; Avila, P.; Harding-Theobald, E.; Wang, C.; Butte, A. J. | Atul J Butte | UCSF | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | health informatics | https://www.medrxiv.org/content/early/2019/08/13/19004598.source.xml | ObjectiveAdministrative healthcare data are an attractive source of secondary analysis because of their potential to answer population-health questions. Although these datasets have known susceptibilities to biases, the degree to which they can distort measurements like cancer screening rates are not widely appreciated... | 10.1136/bmjoq-2019-000856 | medrxiv |
10.1101/19004598 | Accuracy of Medical Billing Data Against the Electronic Health Record in the Measurement of Colorectal Cancer Screening Rates | Rudrapatna, V. A.; Glicksberg, B. S.; Avila, P.; Harding-Theobald, E.; Wang, C.; Butte, A. J. | Atul J Butte | UCSF | 2019-08-22 | 2 | PUBLISHAHEADOFPRINT | cc_no | health informatics | https://www.medrxiv.org/content/early/2019/08/22/19004598.source.xml | ObjectiveAdministrative healthcare data are an attractive source of secondary analysis because of their potential to answer population-health questions. Although these datasets have known susceptibilities to biases, the degree to which they can distort measurements like cancer screening rates are not widely appreciated... | 10.1136/bmjoq-2019-000856 | medrxiv |
10.1101/19004390 | Prospective Trial Registration and Publication Rates of Randomized Clinical Trials in Digital Health: A Cross Sectional Analysis of Global Trial Registries | Al-Durra, M.; Nolan, R. P.; Seto, E.; Cafazzo, J. | Mustafa Al-Durra | Centre for Global eHealth Innovation, Techna Institute, University Health Network | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | health informatics | https://www.medrxiv.org/content/early/2019/08/13/19004390.source.xml | Registration of clinical trials was introduced to mitigate the risk of publication and selective reporting bias in the realm of clinical research. The prevalence of publication and selective reporting bias in trial results has been evidenced through scientific research. This bias may compromise the ethical and methodol... | 10.1177/20552076221090034 | medrxiv |
10.1101/19004713 | Childhood coordination and survival up to six decades later: extended follow-up of participants in the National Child Development Study | Batty, G. D.; Deary, I.; Hamer, M.; Ritchie, S.; Bann, D. | George David Batty | University College London | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2019/08/13/19004713.source.xml | BackgroundPoorer performance on standard tests of motor coordination in children has emerging links with sedentary behaviour, obesity, and functional capacity in later life. These observations are suggestive of an as-yet untested association of coordination with health outcomes.
ObjectiveTo examine the association of ... | 10.1001/jamanetworkopen.2020.4031 | medrxiv |
10.1101/19003897 | PathFlowAI: A Convenient High-Throughput Workflow for Preprocessing, Deep Learning Analytics and Interpretation in Digital Pathology | Levy, J.; Salas, L. A.; Christensen, B. C.; Sriharan, A.; Vaickus, L. J. | Joshua Levy | Program in Quantitative Biomedical Sciences, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756 ; Department of Epidemiology, Geisel School of Medicine a | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | pathology | https://www.medrxiv.org/content/early/2019/08/13/19003897.source.xml | The diagnosis of disease often requires analysis of a biopsy. Many diagnoses depend not only on the presence of certain features but on their location within the tissue. Recently, a number of deep learning diagnostic aids have been developed to classify digitized biopsy slides. Clinical workflows often involve processi... | 10.1142/9789811215636_0036 | medrxiv |
10.1101/19003897 | PathFlowAI: A High-Throughput Workflow for Preprocessing, Deep Learning and Interpretation in Digital Pathology | Levy, J.; Salas, L. A.; Christensen, B. C.; Sriharan, A.; Vaickus, L. J. | Joshua Levy | Program in Quantitative Biomedical Sciences, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756 ; Department of Epidemiology, Geisel School of Medicine a | 2019-10-25 | 2 | PUBLISHAHEADOFPRINT | cc_no | pathology | https://www.medrxiv.org/content/early/2019/10/25/19003897.source.xml | The diagnosis of disease often requires analysis of a biopsy. Many diagnoses depend not only on the presence of certain features but on their location within the tissue. Recently, a number of deep learning diagnostic aids have been developed to classify digitized biopsy slides. Clinical workflows often involve processi... | 10.1142/9789811215636_0036 | medrxiv |
10.1101/19004010 | A systematic review of medical and clinical research landscapes and quality in Malaysia and Indonesia : the review protocol | Chew, B. H.; Lim, P. Y.; Lee, S. W. H.; Devaraj, N. K.; Ismail, A. H.; Shamsuddin, N. H.; Jahn Kassim, P. S.; Abdul Rashid, A.; Fernandez, A.; Muhamad Zakuan, N.; Teoh, S. H.; Abdullah, A. R.; Ali, H.; Abdul Manap, A. H.; Mohamad, F.; Widyahening, I. S. | Boon How Chew | Department of Family Medicine, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Malaysia | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/08/13/19004010.source.xml | BackgroundResearch landscapes and quality may change in many ways. Much research waste has been increasingly reported. Efforts to improve research performance will need good data on the profiles and performance of past research.
PurposeTo describe the characteristics and quality of clinical and biomedical research in ... | null | medrxiv |
10.1101/19003301 | An Efficient and Robust Approach to Detect Auditory Evoked Responses using Adaptive Averaging | Wang, H.; Ding, X.; Li, B.; Wang, X.; Huang, Z.; Hua, Y.; Wu, H. | Yunfeng Hua | Ear Institute, Shanghai Jiao Tong University School of Medicine | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | otolaryngology | https://www.medrxiv.org/content/early/2019/08/13/19003301.source.xml | Auditory brainstem response (ABR) serves as an objective indication of auditory perception at given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, hearing threshold determination by machine algorithm remains unreliable and thereby still rely on visua... | 10.1016/j.isci.2021.103285 | medrxiv |
10.1101/19003301 | An Efficient and Robust Approach to Detect Auditory Evoked Brainstem Responses using Adaptive Averaging | Wang, H.; Li, B.; Ding, X.; Wang, X.; Huang, Z.; Wu, H.; Hua, Y. | Yunfeng Hua | Ear Institute, Shanghai Jiao Tong University School of Medicine | 2020-01-03 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | otolaryngology | https://www.medrxiv.org/content/early/2020/01/03/19003301.source.xml | Auditory brainstem response (ABR) serves as an objective indication of auditory perception at given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, hearing threshold determination by machine algorithm remains unreliable and thereby still rely on visua... | 10.1016/j.isci.2021.103285 | medrxiv |
10.1101/19003301 | An Efficient and Robust Approach to Detect Auditory Evoked Brainstem Responses by Progressive Sub-average Cross-covariance Analysis | Wang, H.; Li, B.; Ding, X.; Wang, X.; Huang, Z.; Hua, Y.; Wu, H. | Yunfeng Hua | Ear Institute, Shanghai Jiao Tong University School of Medicine | 2020-04-14 | 3 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | otolaryngology | https://www.medrxiv.org/content/early/2020/04/14/19003301.source.xml | Auditory brainstem response (ABR) serves as an objective indication of auditory perception at given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, hearing threshold determination by machine algorithm remains unreliable and thereby still rely on visua... | 10.1016/j.isci.2021.103285 | medrxiv |
10.1101/19003301 | Automated Threshold Determination of Auditory Evoked Brainstem Responses by Cross-correlation Analysis with Varying Sweep Number | Wang, H.; Li, B.; Ding, X.; Wang, X.; Huang, Z.; Hua, Y.; Song, L.; Wu, H. | Yunfeng Hua | Ear Institute, Shanghai Jiao Tong University School of Medicine | 2020-07-02 | 4 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | otolaryngology | https://www.medrxiv.org/content/early/2020/07/02/19003301.source.xml | Auditory brainstem response (ABR) serves as an objective indication of auditory perception at given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, hearing threshold determination by machine algorithm remains unreliable and thereby still rely on visua... | 10.1016/j.isci.2021.103285 | medrxiv |
10.1101/19003301 | Real-time Hearing Threshold Determination of Auditory Brainstem Responses by Cross-correlation Analysis | Wang, H.; Li, B.; Lu, Y.; Han, K.; Sheng, H.; Zhou, J.; Qi, Y.; Wang, X.; Huang, Z.; Song, L.; Hua, Y. | Yunfeng Hua | Ear Institute, Shanghai Jiao Tong University School of Medicine | 2021-05-13 | 5 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | otolaryngology | https://www.medrxiv.org/content/early/2021/05/13/19003301.source.xml | Auditory brainstem response (ABR) serves as an objective indication of auditory perception at given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, hearing threshold determination by machine algorithm remains unreliable and thereby still rely on visua... | 10.1016/j.isci.2021.103285 | medrxiv |
10.1101/19004184 | Lower germline mutation rates in young adults predictlonger lives and longer reproductive lifespans | Cawthon, R. M.; Meeks, H. D.; Sasani, T. A.; Smith, K. R.; Kerber, R. A.; O'Brien, E.; Quinlan, A. R.; Jorde, L. B. | Richard M Cawthon | University of Utah, Dept. of Human Genetics | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2019/08/13/19004184.source.xml | BACKGROUNDAnalysis of sequenced genomes from large three-generation families allows de novo mutations identified in Generation II individuals to be attributed to each of their parents germlines in Generation I. Because germline mutations increase with age, we hypothesized that they directly limit the duration of childb... | 10.1038/s41598-020-66867-0 | medrxiv |
10.1101/19004184 | Lower germline mutation rates in young adults predictlonger lives and longer reproductive lifespans | Cawthon, R. M.; Meeks, H. D.; Sasani, T. A.; Smith, K. R.; Kerber, R. A.; O'Brien, E.; Quinlan, A. R.; Jorde, L. B. | Richard M Cawthon | University of Utah, Dept. of Human Genetics | 2019-11-05 | 2 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2019/11/05/19004184.source.xml | BACKGROUNDAnalysis of sequenced genomes from large three-generation families allows de novo mutations identified in Generation II individuals to be attributed to each of their parents germlines in Generation I. Because germline mutations increase with age, we hypothesized that they directly limit the duration of childb... | 10.1038/s41598-020-66867-0 | medrxiv |
10.1101/19004184 | Germline mutation rates in young adults predict longevity and reproductive lifespan | Cawthon, R. M.; Meeks, H. D.; Sasani, T. A.; Smith, K. R.; Kerber, R. A.; O'Brien, E.; Baird, L.; Dixon, M. M.; Peiffer, A. P.; Leppert, M. F.; Quinlan, A. R.; Jorde, L. B. | Richard M Cawthon | University of Utah, Dept. of Human Genetics | 2020-01-02 | 3 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2020/01/02/19004184.source.xml | BACKGROUNDAnalysis of sequenced genomes from large three-generation families allows de novo mutations identified in Generation II individuals to be attributed to each of their parents germlines in Generation I. Because germline mutations increase with age, we hypothesized that they directly limit the duration of childb... | 10.1038/s41598-020-66867-0 | medrxiv |
10.1101/19004184 | Germline mutation rates in young adults predict longevity and reproductive lifespan | Cawthon, R. M.; Meeks, H. D.; Sasani, T. A.; Smith, K. R.; Kerber, R. A.; O'Brien, E.; Baird, L.; Dixon, M. M.; Peiffer, A. P.; Leppert, M. F.; Quinlan, A. R.; Jorde, L. B. | Richard M Cawthon | University of Utah, Dept. of Human Genetics | 2020-04-16 | 4 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2020/04/16/19004184.source.xml | BACKGROUNDAnalysis of sequenced genomes from large three-generation families allows de novo mutations identified in Generation II individuals to be attributed to each of their parents germlines in Generation I. Because germline mutations increase with age, we hypothesized that they directly limit the duration of childb... | 10.1038/s41598-020-66867-0 | medrxiv |
10.1101/19004291 | Health Care Provider Compliance with the HIPAA Right of Individual Access: A Scorecard and Survey | McGraw, D. C.; Fitter, N.; Taylor, L. B. | Deven C McGraw | Ciitizen Corporation | 2019-08-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | health policy | https://www.medrxiv.org/content/early/2019/08/13/19004291.source.xml | BackgroundHistorically, patients have had difficulty obtaining copies of their medical records, notwithstanding the legal right to do so. In 2018, a study of 83 top hospitals found discrepancies between those hospitals published information and telephone survey responses regarding their processes for release of records... | null | medrxiv |
10.1101/19004291 | Health Care Provider Compliance with the HIPAA Right of Individual Access: A Scorecard and Survey | McGraw, D. C.; Fitter, N.; Taylor, L. B. | Deven C McGraw | Ciitizen Corporation | 2019-11-11 | 2 | PUBLISHAHEADOFPRINT | cc_no | health policy | https://www.medrxiv.org/content/early/2019/11/11/19004291.source.xml | BackgroundHistorically, patients have had difficulty obtaining copies of their medical records, notwithstanding the legal right to do so. In 2018, a study of 83 top hospitals found discrepancies between those hospitals published information and telephone survey responses regarding their processes for release of records... | null | medrxiv |
10.1101/19004150 | Peripheral Biomarkers of Tobacco-Use Disorder: A Systematic Review | Newton, D. F. | Dwight F Newton | University of Toronto | 2019-08-14 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | addiction medicine | https://www.medrxiv.org/content/early/2019/08/14/19004150.source.xml | IntroductionTobacco use disorder (TUD) is a major worldwide healthcare burden resulting in 7 million deaths annually. TUD has few approved cessation aids, all of which are associated a high rate of relapse within one year. Biomarkers of TUD severity, treatment response, and risk of relapse have high potential clinical ... | 10.24966/AAD-7276/100026 | medrxiv |
10.1101/19003830 | Assessment of Bias in Estimates of Sexual Network Degree using Prospective Cohort Data | Uong, S.; Rosenberg, E. S.; Goodreau, S. M.; Luisi, N.; Sullivan, P. S.; Jenness, S. M. | Samuel M Jenness | Department of Epidemiology, Emory University | 2019-08-14 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/08/14/19003830.source.xml | BackgroundSexual network degree, a count of ongoing partnerships, plays a critical role in the transmission dynamics of human immunodeficiency virus (HIV) and other sexually transmitted infections (STI). Researchers often quantify degree using self-reported cross-sectional data on the day of survey, which may result in... | 10.1097/EDE.0000000000001151 | medrxiv |
10.1101/19003830 | Assessment of Bias in Estimates of Sexual Network Degree using Prospective Cohort Data | Uong, S.; Rosenberg, E. S.; Goodreau, S. M.; Luisi, N.; Sullivan, P. S.; Jenness, S. M. | Samuel M Jenness | Department of Epidemiology, Emory University | 2019-11-22 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/11/22/19003830.source.xml | BackgroundSexual network degree, a count of ongoing partnerships, plays a critical role in the transmission dynamics of human immunodeficiency virus (HIV) and other sexually transmitted infections (STI). Researchers often quantify degree using self-reported cross-sectional data on the day of survey, which may result in... | 10.1097/EDE.0000000000001151 | medrxiv |
10.1101/19004267 | A comparison of contemporary versus older studies of aspirin for primary prevention | Moriarty, F.; Ebell, M. H. | Mark H Ebell | University of Georgia | 2019-08-15 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/08/15/19004267.source.xml | ObjectiveThis study compares the benefits and harms of aspirin for primary prevention before and after widespread use of statins and colorectal cancer screening.
MethodsWe compared studies of aspirin for primary prevention that recruited patients from 2005 onward with previous individual patient meta-analyses that rec... | 10.1093/fampra/cmz080 | medrxiv |
10.1101/19003947 | Multidrug therapy with terbinafine and itraconazole is not superior to itraconazole alone in current epidemic of altered dermatophytosis in India: A randomized pragmatic trial | Singh, S.; Anchan, V. N.; Chandra, U.; Raheja, R. | Sanjay Singh | Institute of Medical Sciences, Banaras Hindu University, Varanasi, India | 2019-08-15 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | dermatology | https://www.medrxiv.org/content/early/2019/08/15/19003947.source.xml | BackgroundTreatment responsiveness of dermatophytosis has decreased considerably in recent past in India. We compared effectiveness of oral terbinafine daily (Terb) (active control) versus itraconazole daily (Itra) versus terbinafine plus itraconazole daily (TI) versus terbinafine daily plus itraconazole pulse (TIp) in... | null | medrxiv |
10.1101/19003715 | Elucidating user behaviours in a digital health surveillance system to correct prevalence estimates | Liu, D.; Mitchell, L.; Cope, R. C.; Carlson, S. J.; Ross, J. V. | Dennis Liu | The University of Adelaide | 2019-08-15 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/08/15/19003715.source.xml | Estimating seasonal influenza prevalence is of undeniable public health importance, but remains challenging with traditional datasets due to cost and timeliness. Digital epidemiology has the potential to address this challenge, but can introduce sampling biases that are distinct to traditional systems. In online partic... | 10.1016/j.epidem.2020.100404 | medrxiv |
10.1101/19003715 | Elucidating user behaviours in a digital health surveillance system to correct prevalence estimates | Liu, D.; Mitchell, L.; Cope, R. C.; Carlson, S. J.; Ross, J. V. | Dennis Liu | The University of Adelaide | 2020-02-07 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2020/02/07/19003715.source.xml | Estimating seasonal influenza prevalence is of undeniable public health importance, but remains challenging with traditional datasets due to cost and timeliness. Digital epidemiology has the potential to address this challenge, but can introduce sampling biases that are distinct to traditional systems. In online partic... | 10.1016/j.epidem.2020.100404 | medrxiv |
10.1101/19003814 | Measuring Baseline Health with Individual Health-Adjusted Life Expectancy (iHALE) | Johansson, K. A.; Okland, J.-M.; Skaftun, E. K.; Bukhman, G.; Norheim, O. F.; Coates, M. M.; Haaland, O. A. | Øystein Ariansen Haaland | Bergen Centre for Ethics and Priority Setting (BCEPS), Department of Global Public Health and Primary Care, University of Bergen, Norway | 2019-08-15 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | medical ethics | https://www.medrxiv.org/content/early/2019/08/15/19003814.source.xml | ObjectivesAt any point of time, a persons baseline health is the number of healthy life years they are expected to experience during the course of their lifetime. In this article we propose an equity-relevant health metric, illness-specific individual Health Adjusted Life Expectancy (iHALE), that facilitates comparison... | null | medrxiv |
10.1101/19003848 | Diet-derived fruit and vegetable metabolites suggest sex-specific mechanisms conferring protection against osteoporosis in humans | Mangano, K. M.; Noel, S. E.; Lai, C.-Q.; Christensen, J. J.; Ordovas, J. M.; Dawson-Hughes, B.; Tucker, K. L.; Parnell, L. D. | Kelsey M Mangano | University of Massachusetts, Lowell | 2019-08-15 | 1 | PUBLISHAHEADOFPRINT | cc0 | nutrition | https://www.medrxiv.org/content/early/2019/08/15/19003848.source.xml | The impact of nutrition on the metabolic profile of osteoporosis is incompletely characterized. The objective of this cross-sectional study was to detangle the association of fruit and vegetable (FV) intakes with osteoporosis prevalence. Dietary, anthropometric and blood plasma metabolite data were examined from the Bo... | 10.1016/j.bone.2020.115780 | medrxiv |
10.1101/19004762 | Why Westerners Are Dissatisfied: A Cross-Sectional Study Identifying State-Level Factors Associated with Variation in Private Health Insurance Satisfaction | McLeod, M. R.; Berinstein, J. A.; Steiner, C. A.; Cushing, K.; Cohen Mekelburg, S. A.; Higgins, P. D. R. | Megan Rose McLeod | University of Michigan Medical School | 2019-08-16 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | health policy | https://www.medrxiv.org/content/early/2019/08/16/19004762.source.xml | ImportanceLarge regional variations in consumer satisfaction with private health insurance plans have been observed, but the factors driving this variation are unknown.
ObjectiveTo identify explanatory state-level and insurance family-level predictors of satsifaction with private health insurance.
DesignCross-section... | null | medrxiv |
10.1101/19004762 | Why Westerners Are Dissatisfied: A Cross-Sectional Study Identifying State-Level Factors Associated with Variation in Private Health Insurance Satisfaction | McLeod, M. R.; Berinstein, J. A.; Steiner, C. A.; Cushing, K.; Cohen Mekelburg, S. A.; Higgins, P. D. R. | Megan Rose McLeod | University of Michigan Medical School | 2019-08-22 | 2 | PUBLISHAHEADOFPRINT | cc_by_nd | health policy | https://www.medrxiv.org/content/early/2019/08/22/19004762.source.xml | ImportanceLarge regional variations in consumer satisfaction with private health insurance plans have been observed, but the factors driving this variation are unknown.
ObjectiveTo identify explanatory state-level and insurance family-level predictors of satsifaction with private health insurance.
DesignCross-section... | null | medrxiv |
10.1101/19003681 | Redefining the Bladder Cancer Phenotype using Patterns of Familial Risk | Hanson, H. A.; Leiser, C. L.; Martin, C.; Gupta, S.; Smith, K. R.; Dechet, C.; Lowrance, W.; O'Neil, B.; Camp, N. J. | Heidi A Hanson | University of Utah | 2019-08-16 | 1 | PUBLISHAHEADOFPRINT | cc_no | epidemiology | https://www.medrxiv.org/content/early/2019/08/16/19003681.source.xml | Relatives of bladder cancer (BCa) patients have been shown to be at increased risk for kidney, lung, thyroid, and cervical cancer after correcting for smoking related behaviors that may concentrate in some families. We demonstrate a new method to simultaneously assess risks for multiple cancers to identify distinct mul... | null | medrxiv |
10.1101/19004499 | Rationalising neurosurgical head injury referrals: The development and implementation of the Liverpool Head Injury Tomography Score (Liverpool HITS) for mild traumatic brain injury | Gillespie, C. S.; McLeavy, C. M.; Islim, A. I.; Prescott, S.; McMahon, C. J. | Conor SN Gillespie | University of Liverpool | 2019-08-17 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | surgery | https://www.medrxiv.org/content/early/2019/08/17/19004499.source.xml | ObjectivesTo develop and implement a radiological scoring system to define a surgically significant mild Traumatic Brain Injury (TBI), stratify neurosurgical referrals and improve communication between referral centres and neurosurgical units.
DesignRetrospective single centre case-control analysis of ten continuous ... | 10.1080/02688697.2019.1710825 | medrxiv |
10.1101/19004499 | Rationalising neurosurgical head injury referrals: The development and implementation of the Liverpool Head Injury Tomography Score (Liverpool HITS) for mild traumatic brain injury | Gillespie, C. S.; McLeavy, C. M.; Islim, A. I.; Prescott, S.; McMahon, C. J. | Conor SN Gillespie | University of Liverpool | 2019-08-26 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | surgery | https://www.medrxiv.org/content/early/2019/08/26/19004499.source.xml | ObjectivesTo develop and implement a radiological scoring system to define a surgically significant mild Traumatic Brain Injury (TBI), stratify neurosurgical referrals and improve communication between referral centres and neurosurgical units.
DesignRetrospective single centre case-control analysis of ten continuous ... | 10.1080/02688697.2019.1710825 | medrxiv |
10.1101/19004622 | Atypical somatic symptoms in adults with prolonged recovery from mild traumatic brain injury | Stubbs, J. L.; Green, K. E.; Silverberg, N. D.; Howard, A.; Dhariwal, A.; Brubacher, J. R.; Garraway, N.; Heran, M. K. S.; Sekhon, M. S.; Aquino, A.; Purcell, V.; Hutchison, J. S.; Torres, I. J.; Panenka, W. J.; CanTBI (National biobank and database of pat...), ; CTRC (Canadian traumatic brain injury research...), | William J. Panenka | University of British Columbia | 2019-08-17 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | neurology | https://www.medrxiv.org/content/early/2019/08/17/19004622.source.xml | Somatization may contribute to persistent symptoms after mild traumatic brain injury (mTBI). In two independently-recruited study samples, we characterized the extent to which symptoms atypical of mTBI but typical for somatoform disorders (e.g., gastrointestinal upset, joint pain) were present in adult patients with pr... | 10.3389/fneur.2020.00043 | medrxiv |
10.1101/19004473 | Evaluation of a rapid lateral flow calprotectin test for the diagnosis of prosthetic joint infection | Trotter, A. J.; Dean, R.; Whitehouse, C. E.; Mikalsen, J.; Hill, C.; Brunton-Sim, R.; Kay, G. L.; Shakokhani, M.; Durst, A.; Wain, J.; McNamara, I.; O'Grady, J. | Alexander J Trotter | University of East Anglia | 2019-08-17 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc | orthopedics | https://www.medrxiv.org/content/early/2019/08/17/19004473.source.xml | BackgroundMicrobiological diagnosis of prosthetic joint infection (PJI) relies on culture techniques that are slow and insensitive. Rapid tests are urgently required to improve patient management. Calprotectin is a neutrophil biomarker of inflammation that has been demonstrated to be effective for the diagnosis of PJI.... | 10.1302/2046-3758.95.BJR-2019-0213.R1 | medrxiv |
10.1101/19004846 | The Implementation, Diagnostic Yield and Clinical Outcome of Genetic Testing on an Inpatient Child and Adolescent Psychiatry Service | Besterman, A. D.; Sadik, J.; Enenbach, M. J.; Quintero-Rivera, F.; UCLA Clinical Genomics Center, ; DeAntonio, M.; Martinez-Agosto, J. A. | Aaron D Besterman | University of California Los Angeles | 2019-08-17 | 1 | PUBLISHAHEADOFPRINT | cc_no | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/08/17/19004846.source.xml | ObjectiveDiagnostic genetic testing is recommended for children with neurodevelopmental disorders (NDDs). However, many children with NDDs do not receive genetic testing. One approach to improve access to genetic services for these patients is to offer testing on the inpatient child and adolescent psychiatry (CAP) serv... | 10.1002/aur.2338 | medrxiv |
10.1101/19004846 | The Implementation, Diagnostic Yield and Clinical Outcome of Genetic Testing on an Inpatient Child and Adolescent Psychiatry Service | Besterman, A. D.; Sadik, J.; Enenbach, M. J.; Quintero-Rivera, F.; UCLA Clinical Genomics Center, ; DeAntonio, M.; Martinez-Agosto, J. A. | Aaron D Besterman | University of California Los Angeles | 2019-09-14 | 2 | PUBLISHAHEADOFPRINT | cc_no | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/09/14/19004846.source.xml | ObjectiveDiagnostic genetic testing is recommended for children with neurodevelopmental disorders (NDDs). However, many children with NDDs do not receive genetic testing. One approach to improve access to genetic services for these patients is to offer testing on the inpatient child and adolescent psychiatry (CAP) serv... | 10.1002/aur.2338 | medrxiv |
10.1101/19004937 | A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative | Westerman, K.; Liu, Q.; Liu, S.; Parnell, L. D.; Sebastiani, P.; Jacques, P.; DeMeo, D. L.; Ordovas, J. M. | Jose M. Ordovas | JM-USDA Human Nutrition Research Center on Aging | 2019-08-17 | 1 | PUBLISHAHEADOFPRINT | cc_no | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/08/17/19004937.source.xml | While diet response prediction for cardiometabolic risk factors (CRFs) has been demonstrated using single SNPs and main-effect genetic risk scores, little investigation has gone into the development of genome-wide diet response scores. We sought to leverage the multi-study setup of the Womens Health Initiative cohort t... | 10.1093/ajcn/nqaa037 | medrxiv |
10.1101/19004770 | Challenges in Building and Maintaining Rare Disease Patient Registries: Results of a Questionnaire Survey in Japan at 2012 | Morita, M.; Ogishima, S. | Mizuki Morita | Okayama University | 2019-08-17 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | health informatics | https://www.medrxiv.org/content/early/2019/08/17/19004770.source.xml | BackgroundResearch infrastructure such as patient registries and biobanks is expected to play important roles by aggregating information and biospecimens to promote research and development for rare diseases. However, both building and maintaining them can be costly. This paper presents results of a survey of patient r... | null | medrxiv |
10.1101/19004440 | Medal: a patient similarity metric using medication prescribing patterns | Lopez Pineda, A.; Pourshafeie, A.; Ioannidis, A.; McCloskey Leibold, C.; Chan, A.; Frankovich, J.; Bustamante, C. D.; Wojcik, G. L. | Arturo Lopez Pineda | Stanford University | 2019-08-17 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | health informatics | https://www.medrxiv.org/content/early/2019/08/17/19004440.source.xml | ObjectivePediatric acute-onset neuropsychiatric syndrome (PANS) is a complex neuropsychiatric syndrome characterized by an abrupt onset of obsessive-compulsive symptoms and/or severe eating restrictions, along with at least two concomitant debilitating cognitive, behavioral, or neurological symptoms. A wide range of ph... | null | medrxiv |
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