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Immunology is a science that examines the structure and function of the immune system. It originates from medicine and early studies on the causes of immunity to disease. The earliest known reference to immunity was during the plague of Athens in 430 BC. Thucydides noted that people who had recovered from a previous bo... |
The immune system protects organisms from infection with layered defenses of increasing specificity. In simple terms, physical barriers prevent pathogens such as bacteria and viruses from entering the organism. If a pathogen breaches these barriers, the innate immune system provides an immediate, but non-specific respo... |
Both innate and adaptive immunity depend on the ability of the immune system to distinguish between self and non-self molecules. In immunology, self molecules are those components of an organism's body that can be distinguished from foreign substances by the immune system. Conversely, non-self molecules are those recog... |
Microorganisms or toxins that successfully enter an organism encounter the cells and mechanisms of the innate immune system. The innate response is usually triggered when microbes are identified by pattern recognition receptors, which recognize components that are conserved among broad groups of microorganisms, or when... |
Several barriers protect organisms from infection, including mechanical, chemical, and biological barriers. The waxy cuticle of many leaves, the exoskeleton of insects, the shells and membranes of externally deposited eggs, and skin are examples of mechanical barriers that are the first line of defense against infectio... |
Chemical barriers also protect against infection. The skin and respiratory tract secrete antimicrobial peptides such as the β-defensins. Enzymes such as lysozyme and phospholipase A2 in saliva, tears, and breast milk are also antibacterials. Vaginal secretions serve as a chemical barrier following menarche, when they b... |
Within the genitourinary and gastrointestinal tracts, commensal flora serve as biological barriers by competing with pathogenic bacteria for food and space and, in some cases, by changing the conditions in their environment, such as pH or available iron. This reduces the probability that pathogens will reach sufficient... |
Inflammation is one of the first responses of the immune system to infection. The symptoms of inflammation are redness, swelling, heat, and pain, which are caused by increased blood flow into tissue. Inflammation is produced by eicosanoids and cytokines, which are released by injured or infected cells. Eicosanoids incl... |
Phagocytosis is an important feature of cellular innate immunity performed by cells called 'phagocytes' that engulf, or eat, pathogens or particles. Phagocytes generally patrol the body searching for pathogens, but can be called to specific locations by cytokines. Once a pathogen has been engulfed by a phagocyte, it be... |
Neutrophils and macrophages are phagocytes that travel throughout the body in pursuit of invading pathogens. Neutrophils are normally found in the bloodstream and are the most abundant type of phagocyte, normally representing 50% to 60% of the total circulating leukocytes. During the acute phase of inflammation, partic... |
Leukocytes (white blood cells) act like independent, single-celled organisms and are the second arm of the innate immune system. The innate leukocytes include the phagocytes (macrophages, neutrophils, and dendritic cells), mast cells, eosinophils, basophils, and natural killer cells. These cells identify and eliminate ... |
Dendritic cells (DC) are phagocytes in tissues that are in contact with the external environment; therefore, they are located mainly in the skin, nose, lungs, stomach, and intestines. They are named for their resemblance to neuronal dendrites, as both have many spine-like projections, but dendritic cells are in no way ... |
Natural killer cells, or NK cells, are a component of the innate immune system which does not directly attack invading microbes. Rather, NK cells destroy compromised host cells, such as tumor cells or virus-infected cells, recognizing such cells by a condition known as "missing self." This term describes cells with low... |
The adaptive immune system evolved in early vertebrates and allows for a stronger immune response as well as immunological memory, where each pathogen is "remembered" by a signature antigen. The adaptive immune response is antigen-specific and requires the recognition of specific "non-self" antigens during a process ca... |
Both B cells and T cells carry receptor molecules that recognize specific targets. T cells recognize a "non-self" target, such as a pathogen, only after antigens (small fragments of the pathogen) have been processed and presented in combination with a "self" receptor called a major histocompatibility complex (MHC) mole... |
Killer T cells are a sub-group of T cells that kill cells that are infected with viruses (and other pathogens), or are otherwise damaged or dysfunctional. As with B cells, each type of T cell recognizes a different antigen. Killer T cells are activated when their T cell receptor (TCR) binds to this specific antigen in ... |
Helper T cells express T cell receptors (TCR) that recognize antigen bound to Class II MHC molecules. The MHC:antigen complex is also recognized by the helper cell's CD4 co-receptor, which recruits molecules inside the T cell (e.g., Lck) that are responsible for the T cell's activation. Helper T cells have a weaker ass... |
Gamma delta T cells (γδ T cells) possess an alternative T cell receptor (TCR) as opposed to CD4+ and CD8+ (αβ) T cells and share the characteristics of helper T cells, cytotoxic T cells and NK cells. The conditions that produce responses from γδ T cells are not fully understood. Like other 'unconventional' T cell subse... |
A B cell identifies pathogens when antibodies on its surface bind to a specific foreign antigen. This antigen/antibody complex is taken up by the B cell and processed by proteolysis into peptides. The B cell then displays these antigenic peptides on its surface MHC class II molecules. This combination of MHC and antige... |
When B cells and T cells are activated and begin to replicate, some of their offspring become long-lived memory cells. Throughout the lifetime of an animal, these memory cells remember each specific pathogen encountered and can mount a strong response if the pathogen is detected again. This is "adaptive" because it occ... |
Newborn infants have no prior exposure to microbes and are particularly vulnerable to infection. Several layers of passive protection are provided by the mother. During pregnancy, a particular type of antibody, called IgG, is transported from mother to baby directly across the placenta, so human babies have high levels... |
Hormones can act as immunomodulators, altering the sensitivity of the immune system. For example, female sex hormones are known immunostimulators of both adaptive and innate immune responses. Some autoimmune diseases such as lupus erythematosus strike women preferentially, and their onset often coincides with puberty. ... |
When suffering from sleep deprivation, active immunizations may have a diminished effect and may result in lower antibody production, and a lower immune response, than would be noted in a well-rested individual. Additionally, proteins such as NFIL3, which have been shown to be closely intertwined with both T-cell diffe... |
It is conjectured that a progressive decline in hormone levels with age is partially responsible for weakened immune responses in aging individuals. Conversely, some hormones are regulated by the immune system, notably thyroid hormone activity. The age-related decline in immune function is also related to decreasing vi... |
The main response of the immune system to tumors is to destroy the abnormal cells using killer T cells, sometimes with the assistance of helper T cells. Tumor antigens are presented on MHC class I molecules in a similar way to viral antigens. This allows killer T cells to recognize the tumor cell as abnormal. NK cells ... |
Unlike animals, plants lack phagocytic cells, but many plant immune responses involve systemic chemical signals that are sent through a plant. Individual plant cells respond to molecules associated with pathogens known as Pathogen-associated molecular patterns or PAMPs. When a part of a plant becomes infected, the plan... |
Overactive immune responses comprise the other end of immune dysfunction, particularly the autoimmune disorders. Here, the immune system fails to properly distinguish between self and non-self, and attacks part of the body. Under normal circumstances, many T cells and antibodies react with "self" peptides. One of the f... |
Immunodeficiencies occur when one or more of the components of the immune system are inactive. The ability of the immune system to respond to pathogens is diminished in both the young and the elderly, with immune responses beginning to decline at around 50 years of age due to immunosenescence. In developed countries, o... |
Long-term active memory is acquired following infection by activation of B and T cells. Active immunity can also be generated artificially, through vaccination. The principle behind vaccination (also called immunization) is to introduce an antigen from a pathogen in order to stimulate the immune system and develop spec... |
The success of any pathogen depends on its ability to elude host immune responses. Therefore, pathogens evolved several methods that allow them to successfully infect a host, while evading detection or destruction by the immune system. Bacteria often overcome physical barriers by secreting enzymes that digest the barri... |
In the mid-1950s, Frank Burnet, inspired by a suggestion made by Niels Jerne, formulated the clonal selection theory (CST) of immunity. On the basis of CST, Burnet developed a theory of how an immune response is triggered according to the self/nonself distinction: "self" constituents (constituents of the body) do not t... |
Anti-inflammatory drugs are often used to control the effects of inflammation. Glucocorticoids are the most powerful of these drugs; however, these drugs can have many undesirable side effects, such as central obesity, hyperglycemia, osteoporosis, and their use must be tightly controlled. Lower doses of anti-inflammato... |
In contrast, during wake periods differentiated effector cells, such as cytotoxic natural killer cells and CTLs (cytotoxic T lymphocytes), peak in order to elicit an effective response against any intruding pathogens. As well during awake active times, anti-inflammatory molecules, such as cortisol and catecholamines, p... |
When a T-cell encounters a foreign pathogen, it extends a vitamin D receptor. This is essentially a signaling device that allows the T-cell to bind to the active form of vitamin D, the steroid hormone calcitriol. T-cells have a symbiotic relationship with vitamin D. Not only does the T-cell extend a vitamin D receptor,... |
Pattern recognition receptors are proteins used by nearly all organisms to identify molecules associated with pathogens. Antimicrobial peptides called defensins are an evolutionarily conserved component of the innate immune response found in all animals and plants, and represent the main form of invertebrate systemic i... |
Evolution of the adaptive immune system occurred in an ancestor of the jawed vertebrates. Many of the classical molecules of the adaptive immune system (e.g., immunoglobulins and T cell receptors) exist only in jawed vertebrates. However, a distinct lymphocyte-derived molecule has been discovered in primitive jawless v... |
It is likely that a multicomponent, adaptive immune system arose with the first vertebrates, as invertebrates do not generate lymphocytes or an antibody-based humoral response. Many species, however, utilize mechanisms that appear to be precursors of these aspects of vertebrate immunity. Immune systems appear even in t... |
Immunology is strongly experimental in everyday practice but is also characterized by an ongoing theoretical attitude. Many theories have been suggested in immunology from the end of the nineteenth century up to the present time. The end of the 19th century and the beginning of the 20th century saw a battle between "ce... |
Clearly, some tumors evade the immune system and go on to become cancers. Tumor cells often have a reduced number of MHC class I molecules on their surface, thus avoiding detection by killer T cells. Some tumor cells also release products that inhibit the immune response; for example by secreting the cytokine TGF-β, wh... |
Hypersensitivity is an immune response that damages the body's own tissues. They are divided into four classes (Type I – IV) based on the mechanisms involved and the time course of the hypersensitive reaction. Type I hypersensitivity is an immediate or anaphylactic reaction, often associated with allergy. Symptoms can ... |
An evasion strategy used by several pathogens to avoid the innate immune system is to hide within the cells of their host (also called intracellular pathogenesis). Here, a pathogen spends most of its life-cycle inside host cells, where it is shielded from direct contact with immune cells, antibodies and complement. Som... |
The mechanisms used to evade the adaptive immune system are more complicated. The simplest approach is to rapidly change non-essential epitopes (amino acids and/or sugars) on the surface of the pathogen, while keeping essential epitopes concealed. This is called antigenic variation. An example is HIV, which mutates rap... |
Another important role of the immune system is to identify and eliminate tumors. This is called immune surveillance. The transformed cells of tumors express antigens that are not found on normal cells. To the immune system, these antigens appear foreign, and their presence causes immune cells to attack the transformed ... |
Larger drugs (>500 Da) can provoke a neutralizing immune response, particularly if the drugs are administered repeatedly, or in larger doses. This limits the effectiveness of drugs based on larger peptides and proteins (which are typically larger than 6000 Da). In some cases, the drug itself is not immunogenic, but may... |
In addition to the negative consequences of sleep deprivation, sleep and the intertwined circadian system have been shown to have strong regulatory effects on immunological functions affecting both the innate and the adaptive immunity. First, during the early slow-wave-sleep stage, a sudden drop in blood levels of cort... |
Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that p... |
In humans, this response is activated by complement binding to antibodies that have attached to these microbes or the binding of complement proteins to carbohydrates on the surfaces of microbes. This recognition signal triggers a rapid killing response. The speed of the response is a result of signal amplification that... |
The Intergovernmental Panel on Climate Change (IPCC) is a scientific intergovernmental body under the auspices of the United Nations, set up at the request of member governments. It was first established in 1988 by two United Nations organizations, the World Meteorological Organization (WMO) and the United Nations Envi... |
Korean economist Hoesung Lee is the chair of the IPCC since October 8, 2015, following the election of the new IPCC Bureau. Before this election, the IPCC was led by his vice-Chair Ismail El Gizouli, who was designated acting Chair after the resignation of Rajendra K. Pachauri in February 2015. The previous chairs were... |
The IPCC Panel is composed of representatives appointed by governments and organizations. Participation of delegates with appropriate expertise is encouraged. Plenary sessions of the IPCC and IPCC Working groups are held at the level of government representatives. Non Governmental and Intergovernmental Organizations ma... |
The IPCC receives funding through the IPCC Trust Fund, established in 1989 by the United Nations Environment Programme (UNEP) and the World Meteorological Organization (WMO), Costs of the Secretary and of housing the secretariat are provided by the WMO, while UNEP meets the cost of the Depute Secretary. Annual cash con... |
The IPCC does not carry out research nor does it monitor climate related data. Lead authors of IPCC reports assess the available information about climate change based on published sources. According to IPCC guidelines, authors should give priority to peer-reviewed sources. Authors may refer to non-peer-reviewed source... |
Each chapter has a number of authors who are responsible for writing and editing the material. A chapter typically has two "coordinating lead authors", ten to fifteen "lead authors", and a somewhat larger number of "contributing authors". The coordinating lead authors are responsible for assembling the contributions of... |
The executive summary of the WG I Summary for Policymakers report says they are certain that emissions resulting from human activities are substantially increasing the atmospheric concentrations of the greenhouse gases, resulting on average in an additional warming of the Earth's surface. They calculate with confidence... |
In 2001, 16 national science academies issued a joint statement on climate change. The joint statement was made by the Australian Academy of Science, the Royal Flemish Academy of Belgium for Science and the Arts, the Brazilian Academy of Sciences, the Royal Society of Canada, the Caribbean Academy of Sciences, the Chin... |
IPCC author Richard Lindzen has made a number of criticisms of the TAR. Among his criticisms, Lindzen has stated that the WGI Summary for Policymakers (SPM) does not faithfully summarize the full WGI report. For example, Lindzen states that the SPM understates the uncertainty associated with climate models. John Hought... |
In addition to climate assessment reports, the IPCC is publishing Special Reports on specific topics. The preparation and approval process for all IPCC Special Reports follows the same procedures as for IPCC Assessment Reports. In the year 2011 two IPCC Special Report were finalized, the Special Report on Renewable Ene... |
The IPCC concentrates its activities on the tasks allotted to it by the relevant WMO Executive Council and UNEP Governing Council resolutions and decisions as well as on actions in support of the UNFCCC process. While the preparation of the assessment reports is a major IPCC function, it also supports other activities,... |
This projection was not included in the final summary for policymakers. The IPCC has since acknowledged that the date is incorrect, while reaffirming that the conclusion in the final summary was robust. They expressed regret for "the poor application of well-established IPCC procedures in this instance". The date of 20... |
Former IPCC chairman Robert Watson has said "The mistakes all appear to have gone in the direction of making it seem like climate change is more serious by overstating the impact. That is worrying. The IPCC needs to look at this trend in the errors and ask why it happened". Martin Parry, a climate expert who had been c... |
The third assessment report (TAR) prominently featured a graph labeled "Millennial Northern Hemisphere temperature reconstruction" based on a 1999 paper by Michael E. Mann, Raymond S. Bradley and Malcolm K. Hughes (MBH99), which has been referred to as the "hockey stick graph". This graph extended the similar graph in ... |
These studies were widely presented as demonstrating that the current warming period is exceptional in comparison to temperatures between 1000 and 1900, and the MBH99 based graph featured in publicity. Even at the draft stage, this finding was disputed by contrarians: in May 2000 Fred Singer's Science and Environmental... |
On 23 June 2005, Rep. Joe Barton, chairman of the House Committee on Energy and Commerce wrote joint letters with Ed Whitfield, Chairman of the Subcommittee on Oversight and Investigations demanding full records on climate research, as well as personal information about their finances and careers, from Mann, Bradley an... |
The IPCC Fourth Assessment Report (AR4) published in 2007 featured a graph showing 12 proxy based temperature reconstructions, including the three highlighted in the 2001 Third Assessment Report (TAR); Mann, Bradley & Hughes 1999 as before, Jones et al. 1998 and Briffa 2000 had both been calibrated by newer studies. In... |
On 1 February 2007, the eve of the publication of IPCC's major report on climate, a study was published suggesting that temperatures and sea levels have been rising at or above the maximum rates proposed during the last IPCC report in 2001. The study compared IPCC 2001 projections on temperature and sea level change wi... |
Another example of scientific research which suggests that previous estimates by the IPCC, far from overstating dangers and risks, have actually understated them is a study on projected rises in sea levels. When the researchers' analysis was "applied to the possible scenarios outlined by the Intergovernmental Panel on ... |
Michael Oppenheimer, a long-time participant in the IPCC and coordinating lead author of the Fifth Assessment Report conceded in Science Magazine's State of the Planet 2008-2009 some limitations of the IPCC consensus approach and asks for concurring, smaller assessments of special problems instead of the large scale ap... |
The IPCC process on climate change and its efficiency and success has been compared with dealings with other environmental challenges (compare Ozone depletion and global warming). In case of the Ozone depletion global regulation based on the Montreal Protocol has been successful, in case of Climate Change, the Kyoto Pr... |
According to Sheldon Ungar's comparison with global warming, the actors in the ozone depletion case had a better understanding of scientific ignorance and uncertainties. The ozone case communicated to lay persons "with easy-to-understand bridging metaphors derived from the popular culture" and related to "immediate ris... |
Since the IPCC does not carry out its own research, it operates on the basis of scientific papers and independently documented results from other scientific bodies, and its schedule for producing reports requires a deadline for submissions prior to the report's final release. In principle, this means that any significa... |
In February 2010, in response to controversies regarding claims in the Fourth Assessment Report, five climate scientists – all contributing or lead IPCC report authors – wrote in the journal Nature calling for changes to the IPCC. They suggested a range of new organizational options, from tightening the selection of le... |
A prime number (or a prime) is a natural number greater than 1 that has no positive divisors other than 1 and itself. A natural number greater than 1 that is not a prime number is called a composite number. For example, 5 is prime because 1 and 5 are its only positive integer factors, whereas 6 is composite because it ... |
The property of being prime (or not) is called primality. A simple but slow method of verifying the primality of a given number n is known as trial division. It consists of testing whether n is a multiple of any integer between 2 and . Algorithms much more efficient than trial division have been devised to test the pri... |
There are infinitely many primes, as demonstrated by Euclid around 300 BC. There is no known simple formula that separates prime numbers from composite numbers. However, the distribution of primes, that is to say, the statistical behaviour of primes in the large, can be modelled. The first result in that direction is t... |
Many questions regarding prime numbers remain open, such as Goldbach's conjecture (that every even integer greater than 2 can be expressed as the sum of two primes), and the twin prime conjecture (that there are infinitely many pairs of primes whose difference is 2). Such questions spurred the development of various br... |
Hence, 6 is not prime. The image at the right illustrates that 12 is not prime: 12 = 3 · 4. No even number greater than 2 is prime because by definition, any such number n has at least three distinct divisors, namely 1, 2, and n. This implies that n is not prime. Accordingly, the term odd prime refers to any prime numb... |
Most early Greeks did not even consider 1 to be a number, so they could not consider it to be a prime. By the Middle Ages and Renaissance many mathematicians included 1 as the first prime number. In the mid-18th century Christian Goldbach listed 1 as the first prime in his famous correspondence with Leonhard Euler -- w... |
A large body of mathematical work would still be valid when calling 1 a prime, but Euclid's fundamental theorem of arithmetic (mentioned above) would not hold as stated. For example, the number 15 can be factored as 3 · 5 and 1 · 3 · 5; if 1 were admitted as a prime, these two presentations would be considered differen... |
There are hints in the surviving records of the ancient Egyptians that they had some knowledge of prime numbers: the Egyptian fraction expansions in the Rhind papyrus, for instance, have quite different forms for primes and for composites. However, the earliest surviving records of the explicit study of prime numbers c... |
After the Greeks, little happened with the study of prime numbers until the 17th century. In 1640 Pierre de Fermat stated (without proof) Fermat's little theorem (later proved by Leibniz and Euler). Fermat also conjectured that all numbers of the form 22n + 1 are prime (they are called Fermat numbers) and he verified t... |
The most basic method of checking the primality of a given integer n is called trial division. This routine consists of dividing n by each integer m that is greater than 1 and less than or equal to the square root of n. If the result of any of these divisions is an integer, then n is not a prime, otherwise it is a prim... |
Modern primality tests for general numbers n can be divided into two main classes, probabilistic (or "Monte Carlo") and deterministic algorithms. Deterministic algorithms provide a way to tell for sure whether a given number is prime or not. For example, trial division is a deterministic algorithm because, if performed... |
A particularly simple example of a probabilistic test is the Fermat primality test, which relies on the fact (Fermat's little theorem) that np≡n (mod p) for any n if p is a prime number. If we have a number b that we want to test for primality, then we work out nb (mod b) for a random value of n as our test. A flaw wit... |
are prime. Prime numbers of this form are known as factorial primes. Other primes where either p + 1 or p − 1 is of a particular shape include the Sophie Germain primes (primes of the form 2p + 1 with p prime), primorial primes, Fermat primes and Mersenne primes, that is, prime numbers that are of the form 2p − 1, wher... |
The following table gives the largest known primes of the mentioned types. Some of these primes have been found using distributed computing. In 2009, the Great Internet Mersenne Prime Search project was awarded a US$100,000 prize for first discovering a prime with at least 10 million digits. The Electronic Frontier Fou... |
are prime for any natural number n. Here represents the floor function, i.e., largest integer not greater than the number in question. The latter formula can be shown using Bertrand's postulate (proven first by Chebyshev), which states that there always exists at least one prime number p with n < p < 2n − 2, for any na... |
can have infinitely many primes only when a and q are coprime, i.e., their greatest common divisor is one. If this necessary condition is satisfied, Dirichlet's theorem on arithmetic progressions asserts that the progression contains infinitely many primes. The picture below illustrates this with q = 9: the numbers are... |
The zeta function is closely related to prime numbers. For example, the aforementioned fact that there are infinitely many primes can also be seen using the zeta function: if there were only finitely many primes then ζ(1) would have a finite value. However, the harmonic series 1 + 1/2 + 1/3 + 1/4 + ... diverges (i.e., ... |
The unproven Riemann hypothesis, dating from 1859, states that except for s = −2, −4, ..., all zeroes of the ζ-function have real part equal to 1/2. The connection to prime numbers is that it essentially says that the primes are as regularly distributed as possible.[clarification needed] From a physical viewpoint, it r... |
In addition to the Riemann hypothesis, many more conjectures revolving about primes have been posed. Often having an elementary formulation, many of these conjectures have withstood a proof for decades: all four of Landau's problems from 1912 are still unsolved. One of them is Goldbach's conjecture, which asserts that ... |
A third type of conjectures concerns aspects of the distribution of primes. It is conjectured that there are infinitely many twin primes, pairs of primes with difference 2 (twin prime conjecture). Polignac's conjecture is a strengthening of that conjecture, it states that for every positive integer n, there are infinit... |
For a long time, number theory in general, and the study of prime numbers in particular, was seen as the canonical example of pure mathematics, with no applications outside of the self-interest of studying the topic with the exception of use of prime numbered gear teeth to distribute wear evenly. In particular, number ... |
Giuga's conjecture says that this equation is also a sufficient condition for p to be prime. Another consequence of Fermat's little theorem is the following: if p is a prime number other than 2 and 5, 1/p is always a recurring decimal, whose period is p − 1 or a divisor of p − 1. The fraction 1/p expressed likewise in ... |
Several public-key cryptography algorithms, such as RSA and the Diffie–Hellman key exchange, are based on large prime numbers (for example, 512-bit primes are frequently used for RSA and 1024-bit primes are typical for Diffie–Hellman.). RSA relies on the assumption that it is much easier (i.e., more efficient) to perfo... |
The evolutionary strategy used by cicadas of the genus Magicicada make use of prime numbers. These insects spend most of their lives as grubs underground. They only pupate and then emerge from their burrows after 7, 13 or 17 years, at which point they fly about, breed, and then die after a few weeks at most. The logic ... |
The concept of prime number is so important that it has been generalized in different ways in various branches of mathematics. Generally, "prime" indicates minimality or indecomposability, in an appropriate sense. For example, the prime field is the smallest subfield of a field F containing both 0 and 1. It is either Q... |
Prime numbers give rise to two more general concepts that apply to elements of any commutative ring R, an algebraic structure where addition, subtraction and multiplication are defined: prime elements and irreducible elements. An element p of R is called prime element if it is neither zero nor a unit (i.e., does not ha... |
The fundamental theorem of arithmetic continues to hold in unique factorization domains. An example of such a domain is the Gaussian integers Z[i], that is, the set of complex numbers of the form a + bi where i denotes the imaginary unit and a and b are arbitrary integers. Its prime elements are known as Gaussian prime... |
In ring theory, the notion of number is generally replaced with that of ideal. Prime ideals, which generalize prime elements in the sense that the principal ideal generated by a prime element is a prime ideal, are an important tool and object of study in commutative algebra, algebraic number theory and algebraic geomet... |
Prime ideals are the points of algebro-geometric objects, via the notion of the spectrum of a ring. Arithmetic geometry also benefits from this notion, and many concepts exist in both geometry and number theory. For example, factorization or ramification of prime ideals when lifted to an extension field, a basic proble... |
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