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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
Neutrophil degranulation 0.6193555322517424 3.907893112201576 9.3104476775574e-05 0.115404061091935 0.0046643048656144 144 O00584,P06280,P61916,Q9BTY2,P10253,P17900,P11717,P16278,P15586,Q99519,P11279,P07686,P10619,Q92820,Q92542,Q13510,P10321,P08236,P67870 19
Innate immune system 0.5672198775061972 3.4772296433077035 0.0005066236948432 0.4869553901441542 0.0104253657204457 229 P05067,O00584,P06280,Q8IV08,Q99538,P61916,Q8TBC4,Q9BTY2,P10253,P17900,Q93050,P11717,P16278,P15586,Q99519,P11279,P60900,P07686,P10619,Q9Y487,Q92820,Q92542,Q13510,P30519,P49721,P10321,Q9UQB8,P01889,O15143,P08236,P28072,O95721,P67870,P49427,P42785,P84095,P17858,Q7Z6Z7 38
Diseases of metabolism 0.7601717901019348 3.035914793055447 0.0023980712239823 0.9576612583138098 0.0303638605844384 33 P06865,Q99519,P07686,P10619,P10253,P54802,O43505,P08236,P16278,P15586 10
Sphingolipid metabolism 0.8340087047588362 3.016574548286228 0.0025564834736029 0.9656515979628107 0.0303638605844384 22 P06865,Q99519,P06280,P07686,P10619,P17900,P04062,P16278,Q13510 9
Transport of small molecules 0.5188221228983062 2.878992729557877 0.003989475312083 0.9948287848188836 0.0343407776863619 129 Q9C0H2,P61916,P02786,Q93050,Q658P3,Q8WTV0,Q15904,P60900,Q9Y487,O15118,P51790,Q9H2J7,P38571,P30519,P55011,P49721,P28072,P08195,Q8N4V1,P35613 20
Trans golgi network vesicle budding 0.7410921815117174 2.75887351426685 0.0058000979731454 0.99952914847721 0.047742056441453 28 P05067,P02786,O75976,P11717,P15586 5
Glycosphingolipid metabolism 0.8847874269567346 2.692479380944878 0.0070922920877267 0.9999150823911196 0.0560625206384571 14 P06865,Q99519,P06280,P07686,P10619,P17900,P16278,Q13510 8
Diseases of glycosylation 0.8840407663267004 2.689334571550167 0.007159462281439 0.9999223211179438 0.0560625206384571 14 P06865,Q99519,P07686,P10619,O43505,P16278 6
Cs ds degradation 0.9832721338229296 2.653654598125777 0.0079625286113813 0.9999732405603732 0.0616861775364073 2 P06865 1
Glycosaminoglycan metabolism 0.9165418351228596 2.6259989946954714 0.0086395072551419 0.9999891100166672 0.0660933145113412 11 P06865,P07686,P54802,O43505,P08236,P16278,P15586 7
Nrif signals cell death from the nucleus 0.974296205630355 2.61690222796692 0.008873175315931 0.9999920164427633 0.0671607579947192 2 Q92542 1
Plasma lipoprotein assembly remodeling and clearance 0.8981958355939018 2.613699473719044 0.0089567782230919 0.999992855887156 0.0674061538274976 12 Q8WTV0,P61916,O15118 3
Cargo recognition for clathrin mediated endocytosis 0.7369752859354463 2.5822788522136984 0.0098150244032213 0.9999977175056686 0.072620152466531 23 Q14108,P11717,Q8NC96,P02786 4
Plasma lipoprotein clearance 0.9186635772467602 2.576388043358673 0.0099838531549092 0.9999981766084414 0.0734566179051143 10 Q8WTV0,P61916,O15118 3
Formation of fibrin clot clotting cascade 0.9547123623011018 2.536210173287817 0.0112059457558419 0.9999996415739631 0.0793453255937844 2 Q07021 1
Intrinsic pathway of fibrin clot formation 0.9547123623011018 2.536210173287817 0.0112059457558419 0.9999996415739631 0.0793453255937844 2 Q07021 1
Metabolism of carbohydrates 0.5326878361872288 2.470426868617285 0.0134951909032903 0.999999983070066 0.0914558997047321 83 P06865,P07686,P10253,P54802,O43505,P08236,P16278,P15586 8
Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.8066556216493433 2.4249248278279167 0.0153115568714572 0.9999999985052336 0.1018450525237838 15 Q9BTY2,P05067,Q06481,O43852 4
Ecm proteoglycans 0.923296613627094 2.4053214150973834 0.016158247296349 0.9999999995185476 0.1060342703184681 2 P05067 1
Metabolism of lipids 0.4752720465029422 2.3995196575013074 0.0164165983433663 0.999999999659326 0.1060342703184681 126 P06280,Q8IV08,Q99538,P17900,P50897,P16278,P06865,Q99519,P07686,P10619,Q13510,P35790,O43772,Q9UBM7,Q14849,Q15392,P04062,O15269,Q14739 19
Ion channel transport 0.6912601882056106 2.3938085202598285 0.0166744512174135 0.9999999997588016 0.1066031662783184 24 P61421,Q9HD20,Q15904,P05026,Q9C0H2,Q9Y487,P54709,P51790,Q93050 9
Synthesis of pe 0.9086087311301536 2.3435190836452153 0.0191027849612508 0.9999999999907072 0.1181144027885791 2 P35790 1
Response to elevated platelet cytosolic ca2 0.678194911001279 2.338471761930298 0.0193627888652754 0.9999999999934458 0.1186083392351987 25 P05067,Q08380,Q06481 3
Diseases of carbohydrate metabolism 0.9135031210481568 2.296392822599005 0.0216534309900513 0.9999999999996988 0.1284575162788181 8 P10253,P54802,P16278,P15586 4
Ldl clearance 0.9024235473880994 2.2543637405123036 0.0241732944199433 0.99999999999999 0.1408682688100236 8 P61916,O15118 2
Iron uptake and transport 0.7259842732529282 2.237072105615798 0.0252816277426344 0.9999999999999978 0.1453969595504346 18 Q15904,Q9Y487,P02786,Q93050,Q658P3 5
Golgi associated vesicle biogenesis 0.6592240538067143 2.2308951831313424 0.0256880728881399 0.9999999999999988 0.1458241034210355 25 Q99523,P51809,P02786,Q8NC96,O75976,P11717 6
Transferrin endocytosis and recycling 0.8131454377709977 2.2066554206656797 0.027338141922002 1.0 0.1532099272820283 11 Q93050,Q15904,P02786,Q658P3 4
Keratan sulfate keratin metabolism 0.9844771241830066 2.190117241878148 0.0285157350936233 1.0 0.1577950551189159 5 P06865,P15586,P16278,O43505 4
Keratan sulfate degradation 0.9840751327072272 2.1740933379332943 0.0296981261955568 1.0 0.1636503439311649 4 P06865,P16278,P15586 3
Receptor mediated mitophagy 0.8616891064871521 2.1435502872005525 0.0320689376873681 1.0 0.1759782955594329 2 P67870 1
Diseases associated with glycosylation precursor biosynthesis 0.8729181343823955 2.1414196668941363 0.0322402103539489 1.0 0.176184054091912 8 Q99519,P16278 2
Mitophagy 0.7934004626708819 2.1240460584606753 0.0336662923794952 1.0 0.1792094486619531 11 Q13501,P67870,Q8IWA4,O96008,Q9NS69,Q8N4H5 6
Hs gag degradation 0.9648979591836732 2.1157358344281443 0.0343672810573909 1.0 0.1796099569546979 3 P54802,P16278 2
Heparan sulfate heparin hs gag metabolism 0.9648979591836732 2.1157358344281443 0.0343672810573909 1.0 0.1796099569546979 3 P54802,P16278 2
Mucopolysaccharidoses 0.9652919559003664 2.1052644049168925 0.0352682987371175 1.0 0.1826581079279256 4 P54802,P16278,P15586 3
Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.7500724465608596 2.1039478643315666 0.0353829950881787 1.0 0.1826581079279256 14 Q99519,P16278 2
Tryptophan catabolism 0.8514891880864996 2.099578790991114 0.0357659100903315 1.0 0.1826581079279256 2 P08195 1
Cd28 dependent pi3k akt signaling 0.8510811913504713 2.097816319833804 0.0359213743001767 1.0 0.1826581079279256 2 P31751 1
Synthesis of substrates in n glycan biosythesis 0.7603689882136763 2.090492650881765 0.0365735678760661 1.0 0.1839949419412986 13 Q99519,P16278 2
Amino acid transport across the plasma membrane 0.9558837636311904 2.081848356012594 0.0373563232525964 1.0 0.1863571125896571 3 Q9H2J7 1
Sialic acid metabolism 0.9492976815624994 2.0629188609175837 0.0391203378274847 1.0 0.1915296837130012 5 Q99519,P16278 2
Chondroitin sulfate dermatan sulfate metabolism 0.9497959183673464 2.058901926547481 0.0395036345038768 1.0 0.1919789174967003 3 P06865,P07686 2
Diseases associated with glycosaminoglycan metabolism 0.9497959183673464 2.058901926547481 0.0395036345038768 1.0 0.1919789174967003 3 P06865,P07686 2
Hyaluronan metabolism 0.9466326366024718 2.0364290058251804 0.041707295273476 1.0 0.1997400286369744 4 P06865,P07686 2
Hyaluronan uptake and degradation 0.9466326366024718 2.0364290058251804 0.041707295273476 1.0 0.1997400286369744 4 P06865,P07686 2
Eph ephrin mediated repulsion of cells 0.843420826459577 2.027037547053836 0.0426585729493176 1.0 0.2028207240947701 8 Q15375 1
Toll like receptor cascades 0.6938171154228359 2.02065698039691 0.0433152860325665 1.0 0.2030115007291462 17 P05067 1
Rac3 gtpase cycle 0.6243282267745046 2.015076437642135 0.043896640647939 1.0 0.2050022629490246 24 Q13177,O96013,Q14126,Q9UQB8,P02786,Q9Y2U8,P50402,Q6IAA8,P05556,Q14739 10
Rac2 gtpase cycle 0.6156568402270547 2.011908301480246 0.0442296041551104 1.0 0.2051070023671847 27 Q13177,Q14126,P02786,Q9Y2U8,P50402,Q6IAA8,Q9UH62,P05556,Q14739 9
Extracellular matrix organization 0.6186043094250545 1.981914173733005 0.047488847310356 1.0 0.2138221153381865 24 P05067,Q9Y624,Q92542,P20810,O60568,P35613,P05556,O15460 8
Pink1 prkn mediated mitophagy 0.7830025061498258 1.9807839528421165 0.0476155071568391 1.0 0.2138221153381865 9 Q13501,Q8IWA4,O96008,Q8N4H5 4
Vesicle mediated transport 0.4544964601711099 1.978425852921977 0.0478806856061606 1.0 0.2138221153381865 182 P05067,Q10472,Q9H3P7,Q4KMP7,Q9UIQ6,P02786,Q8NC96,P31751,O75976,Q9BVK6,P11717,Q14108,P15586,Q8WTV0,Q7Z392,Q9UID3,Q9NVZ3,Q99523,O00461,Q9BUF5,Q10471,P24390,Q99747,P27348,P61163,P51809,Q12907,Q9NSK0,P11233,O95721,Q9Y3E7 31
O linked glycosylation 0.9277551020408156 1.9754282823489304 0.0482195658735318 1.0 0.2138221153381865 3 Q10472,O43505 2
O linked glycosylation of mucins 0.9277551020408156 1.9754282823489304 0.0482195658735318 1.0 0.2138221153381865 3 Q10472,O43505 2
Integrin cell surface interactions 0.9236734693877544 1.9599033602562863 0.0500070868020126 1.0 0.2180772626432139 3 Q9Y624,P35613 2
Aryl hydrocarbon receptor signalling 0.9210988223722046 1.9500999010501672 0.0511642130555785 1.0 0.2216554887967002 3 Q15185 1
Lysosome vesicle biogenesis 0.7591399339177225 1.929326274634186 0.0536903698839092 1.0 0.2310791409709429 10 P05067 1
Vitamin d calciferol metabolism 0.9098842878773856 1.9073049569085083 0.0564811086910903 1.0 0.2391820583478006 3 Q99538 1
Rac1 gtpase cycle 0.5840577361942162 1.8791589925162029 0.0602227870660869 1.0 0.2525904795096705 30 Q13177,Q9Y2I1,O96013,Q9UQB8,P02786,Q9Y2U8,P50402,Q6IAA8,P05556,Q14739 10
Membrane trafficking 0.4433188938964474 1.844319643214736 0.0651365704217994 1.0 0.2699564487750818 176 P05067,Q10472,Q9H3P7,Q4KMP7,Q9UIQ6,P02786,Q8NC96,P31751,O75976,Q9BVK6,P11717,Q14108,P15586,Q7Z392,Q9UID3,Q9NVZ3,Q99523,O00461,Q9BUF5,Q10471,P24390,Q99747,P27348,P61163,P51809,Q12907,Q9NSK0,P11233,O95721,Q9Y3E7 30
Clathrin mediated endocytosis 0.5357678828599358 1.8339658247971509 0.0666590673026474 1.0 0.2726397255825675 39 Q14108,P11717,Q8NC96,P02786 4
Insulin receptor recycling 0.745847791030447 1.82682709518901 0.0677257706110441 1.0 0.2744456612146003 9 Q93050,Q15904,Q9Y487 3
Signaling by insulin receptor 0.7235695206199422 1.8254327748471764 0.0679357471766364 1.0 0.2744520829191109 11 Q93050,P31751,Q15904,Q9Y487 4
Cell surface interactions at the vascular wall 0.7318809555171891 1.8137496954064671 0.0697162703734366 1.0 0.2776684557205241 10 P05026,P08195,Q9Y624,Q92896,P35613,P05556 6
Irs mediated signalling 0.7796817625459047 1.78538480182717 0.0741989221290215 1.0 0.2861215091665768 2 P31751 1
Insulin receptor signalling cascade 0.7796817625459047 1.78538480182717 0.0741989221290215 1.0 0.2861215091665768 2 P31751 1
Fceri mediated ca 2 mobilization 0.7796817625459025 1.7853848018271592 0.0741989221290233 1.0 0.2861215091665768 2 O43865 1
Antigen activates b cell receptor bcr leading to generation of second messengers 0.7796817625459025 1.7853848018271592 0.0741989221290233 1.0 0.2861215091665768 2 O43865 1
P75ntr negatively regulates cell cycle via sc1 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.2907006051161517 2 Q13547 1
Gpcr ligand binding 0.7779344266528601 1.7680343306952395 0.0770551645379522 1.0 0.2917844775855253 8 P05067 1
Endosomal vacuolar pathway 0.8708648709787487 1.7524979592372234 0.0796882204702527 1.0 0.2998553895980652 4 P10321,Q9UIQ6 2
Interleukin 1 signaling 0.5140742435006114 1.746530904717124 0.0807187417347694 1.0 0.3020073376837823 44 Q13501,P05067,P49721,P28072 4
Sumoylation of dna methylation proteins 0.7686658506732016 1.7365402922187594 0.082468346446771 1.0 0.3025370815331405 2 Q8IXK0 1
Selective autophagy 0.5739745234374097 1.7307472215070558 0.0834968589762252 1.0 0.3046131946584174 25 Q13501,P67870,Q9BUF5,Q8IWA4,O96008,Q9NS69,Q8N4H5 7
Signaling by notch3 0.8633274275059692 1.7281179982760662 0.0839670713147842 1.0 0.3054824113855546 3 Q92542 1
Regulation of beta cell development 0.8587515745108246 1.7103846988623417 0.0871947585963108 1.0 0.3119558934915238 3 P31751 1
Metabolism of steroids 0.5404306678728701 1.6950159164165286 0.0900724014557816 1.0 0.3163342739127052 34 Q9UBM7,Q99538,Q14849,Q15392,P04062 5
Synthesis of pc 0.8491238632776557 1.6730095255706448 0.0943254208370683 1.0 0.3197499463796453 3 P35790 1
Intra golgi and retrograde golgi to er traffic 0.4635681092773486 1.6728742215989965 0.0943520595433544 1.0 0.3197499463796453 66 Q10472,P40616,Q9BVK6,P11717,Q9UID3,P49755,O00461,Q9BUF5,Q10471,P24390,Q9UJW0,Q9BW19,Q99747,P48444,P61163,Q14203,Q6NUQ1,Q9NSK0,O95721,Q9Y678,P35606 21
Class a 1 rhodopsin like receptors 0.7998082728182723 1.6699484721811548 0.0949295588720131 1.0 0.3197499463796453 7 P05067 1
Peptide ligand binding receptors 0.7998082728182723 1.6699484721811548 0.0949295588720131 1.0 0.3197499463796453 7 P05067 1
Stimuli sensing channels 0.8444272675273816 1.659259758651045 0.0970634604296938 1.0 0.3261035137395581 6 Q9C0H2 1
Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.8394076741645097 1.6555469595637844 0.0978135990717121 1.0 0.3277875571945163 5 P10321,Q92692,P05556 3
Rhoc gtpase cycle 0.5614102220426981 1.6440681731379134 0.1001621212516854 1.0 0.3322758531195711 24 O75955,Q9UDY2,Q12802,Q07021,Q9NQW6,P02786,P28288,Q9H2G2,Q14739 9
Translocation of slc2a4 glut4 to the plasma membrane 0.5564406423514573 1.636742247059933 0.1016843375683136 1.0 0.3339607794949353 26 P68371,P35579,Q9UPT5,Q9UIQ6,P61981,P11233,Q9BUF5,P31751,O60343,P27348 10
Activation of rac1 0.8390807686877467 1.6315220870035134 0.1027802032610054 1.0 0.335884684106065 4 O94813,Q13177 2
Cd209 dc sign signaling 0.7417380660954751 1.6165597106334637 0.1059733545992616 1.0 0.3437608571606589 2 Q13177 1
Runx1 regulates expression of components of tight junctions 0.7384740922072635 1.6019671575851897 0.1091628722075155 1.0 0.3470111206628336 2 Q16625 1
Ctla4 inhibitory signaling 0.8275658536063615 1.5890324817840085 0.1120530595839928 1.0 0.3538487431827007 3 Q14738 1
Diseases of dna repair 0.6884619534749946 1.5843738669213054 0.1131086652594448 1.0 0.3546078711876552 9 Q9UQ84,P54132 2
Rnd1 gtpase cycle 0.6586362877051556 1.5821063196744112 0.1136253011702281 1.0 0.3546078711876552 12 P02786 1
Translation of replicase and assembly of the replication transcription complex 0.731538147694826 1.570927448188845 0.1161995020840787 1.0 0.3577762581421499 2 Q9Y3E7 1
Cdc42 gtpase cycle 0.5634492803005786 1.5706219324427515 0.1162704923954747 1.0 0.3577762581421499 22 Q13177,Q9UQB8,P02786,A4D1P6,Q6IAA8,Q14739,Q658P3 7
Dap12 interactions 0.820919981097298 1.561996658023156 0.1182887761571862 1.0 0.3622937632535216 4 P10321 1
Cytosolic sulfonation of small molecules 0.7262341901264862 1.5471653030038257 0.1218233903054688 1.0 0.3679393169856813 2 Q8TB61 1
Transport and synthesis of paps 0.7262341901264862 1.5471653030038257 0.1218233903054688 1.0 0.3679393169856813 2 Q8TB61 1
Tyrosine catabolism 0.7258261933904564 1.545336580807595 0.1222648715783043 1.0 0.3679393169856813 2 P16930 1
Transport of bile salts and organic acids metal ions and amine compounds 0.8160623473117283 1.5440785015484548 0.1225693162852401 1.0 0.3679393169856813 3 Q9H2J7 1
Retrograde transport at the trans golgi network 0.6570619604879634 1.5323065878901254 0.125446796191134 1.0 0.3723054944034548 11 Q99747,Q9UID3,P11717,P40616 4
Cell death signalling via nrage nrif and nade 0.7186826346321518 1.528267143313619 0.1264462241703441 1.0 0.3725496134951749 8 Q13501,Q92542 2
Interleukin 1 family signaling 0.484157219072017 1.5243977336545516 0.1274093859103442 1.0 0.3745494670623289 45 Q13501,P05067,P49721,P28072 4
Amyloid fiber formation 0.7890610148286984 1.464738590394309 0.1429922519755662 1.0 0.4041218795103448 5 P05067 1
Downregulation of erbb2 erbb3 signaling 0.703794369645051 1.446435046174884 0.1480552180131455 1.0 0.4100886997681422 2 P31751 1
Synaptic adhesion like molecules 0.7806054465337128 1.432517115142651 0.1519958835144415 1.0 0.4175501302378025 5 Q15334,O75955 2
Rhoq gtpase cycle 0.606791220249124 1.4318656313982925 0.1521822798133221 1.0 0.4175501302378025 14 Q658P3,Q13177,P02786,Q6IAA8 4
Fcgamma receptor fcgr dependent phagocytosis 0.5595862737415002 1.4264355568296876 0.1537426562291211 1.0 0.4194825918270304 19 Q9UQB8,Q8IV08 2
Transport of inorganic cations anions and amino acids oligopeptides 0.7370533380529285 1.4259046727068136 0.1538958604539981 1.0 0.4194825918270304 7 Q9H2J7,P08195 2
Bmal1 clock npas2 activates circadian gene expression 0.6984904120767028 1.422591771263725 0.1548545308037887 1.0 0.4196366606349583 2 P43490 1
Notch hlh transcription pathway 0.7771428571428556 1.3914552157550326 0.1640874309837627 1.0 0.4401286081580765 3 Q13547,Q13573 2
Constitutive signaling by aberrant pi3k in cancer 0.7743657864096294 1.3805442129998189 0.1674191464250771 1.0 0.4472434398414333 3 P84095 1
Fceri mediated mapk activation 0.7725128868422977 1.3732634414457088 0.1696704634528889 1.0 0.4514262633685954 3 Q13177 1
Tp53 regulates transcription of cell death genes 0.7684739548530295 1.3600494310975737 0.1738142819698538 1.0 0.460590360873838 4 Q658P3 1
Basigin interactions 0.7619604909815593 1.3522857465225455 0.1762839223089485 1.0 0.462481923667102 6 P08195,P35613,P05026,P05556 4
Resolution of d loop structures 0.7576830573880381 1.3362515278977516 0.1814670740255815 1.0 0.4673985200868195 6 Q9UQ84,P54132 2
Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.7576830573880381 1.3362515278977516 0.1814670740255815 1.0 0.4673985200868195 6 Q9UQ84,P54132 2
Interferon gamma signaling 0.6269898575362534 1.3195703070558464 0.1869785220139503 1.0 0.4753874777845032 9 P10321,Q12899 2
Cd28 co stimulation 0.7495375767611838 1.305702221061554 0.1916538423850902 1.0 0.4811458586196833 6 Q13177,P31751,P42345 3
Rhoj gtpase cycle 0.5800149232516663 1.3019827456486666 0.1929222840105784 1.0 0.4811458586196833 14 Q658P3,Q13177,P02786,Q6IAA8 4
Defective intrinsic pathway for apoptosis 0.5886375646170527 1.2999228442832256 0.1936274146305483 1.0 0.4811458586196833 13 P05067 1
Reduction of cytosolic ca levels 0.7506169922334871 1.29107753174323 0.196676794206742 1.0 0.4868859736283443 4 P30626,P20020 2
Platelet calcium homeostasis 0.7506169922334871 1.29107753174323 0.196676794206742 1.0 0.4868859736283443 4 P30626,P20020 2
Negative regulation of the pi3k akt network 0.7436947602766746 1.2837793576782444 0.1992191682193189 1.0 0.4922544925794428 6 Q14738,P84095,P31751 3
Signal transduction by l1 0.7481684850277457 1.2816191088068634 0.1999762935663285 1.0 0.4922780908913171 4 P67870 1
Antigen processing cross presentation 0.4492303538901649 1.2715857668618595 0.2035203364673121 1.0 0.4970109987289584 48 P60900,P49721,Q9UIQ6,P10321,P01889,P28072 6
Intra golgi traffic 0.6947218929697194 1.2596261826853634 0.2078042457304403 1.0 0.5011393641616317 7 Q99747,O00461 2
Slc mediated transmembrane transport 0.5521841168816307 1.2589120868841923 0.2080620875801992 1.0 0.5011393641616317 16 P55011,P08195,Q9H2J7,P35613 4
Costimulation by the cd28 family 0.6127288868148325 1.2576380621853065 0.2085226815190388 1.0 0.5011393641616317 9 Q14738,Q13177,P31751,P42345 4
Autophagy 0.4712711888615632 1.2405801989614489 0.2147608705029349 1.0 0.5123914247325457 35 Q13501,Q5MNZ6,P67870,Q9Y3E7,Q9BUF5,Q8IWA4,O96008,Q96HS1,Q6IAA8,Q9NS69,Q8N4H5 11
Rhob gtpase cycle 0.557630344861826 1.2375429906398052 0.2158855642946862 1.0 0.5141433782569651 15 Q14254,Q9UDY2,O75955,Q12802,Q16513,Q9NQW6,P02786,Q9H2G2,O75116 9
P75 ntr receptor mediated signalling 0.5665292067219597 1.2362636132542872 0.216360591755842 1.0 0.5143445836506207 14 Q13501,Q92542,Q12802 3
Regulation of localization of foxo transcription factors 0.7241710082365626 1.2105008958376944 0.2260867472242442 1.0 0.5284582605619521 6 P31751,P27348,P61981 3
Leishmania infection 0.488091926187299 1.2099185629560976 0.2263101434752779 1.0 0.5284582605619521 26 P05067 1
Regulated necrosis 0.5576491985406107 1.1929129162437062 0.2329034801794889 1.0 0.5390753662502407 14 P09429,Q9Y3E7,O75955,Q13546 4
G alpha i signalling events 0.5217415203636655 1.1751303946741898 0.2399425521765574 1.0 0.5448632522640785 18 P05067,Q9ULM6 2
Signaling by fgfr1 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Signaling by fgfr4 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Negative regulation of fgfr3 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Negative regulation of fgfr1 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Signaling by fgfr3 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Spry regulation of fgf signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Negative regulation of fgfr2 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Negative regulation of fgfr4 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Platelet homeostasis 0.7090943068182012 1.1539382871714388 0.2485254707909328 1.0 0.5550129701427986 6 Q14738,P20020,P30626 3
Protein protein interactions at synapses 0.5789769280153582 1.144351143929864 0.2524780409538372 1.0 0.5588463528339557 10 Q15334,Q14254,O75955,Q96HC4 4
Activation of bh3 only proteins 0.5783507175772333 1.141567662038156 0.2536337722157795 1.0 0.5604625469935933 10 Q9Y3B8,P31751,P27348,P61981 4
Signaling by notch1 pest domain mutants in cancer 0.6624018114803002 1.132416003453803 0.2574595798224859 1.0 0.5656454515250204 7 Q92542,Q13573 2
Signaling by notch1 0.6223812054061385 1.1315220020831926 0.2578354482116904 1.0 0.5656454515250204 8 Q13547,Q96J02,Q92542,Q13573 4
Cd28 dependent vav1 pathway 0.7081155184715742 1.127119406865662 0.2596919991501933 1.0 0.5681301708983466 4 Q13177 1
Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.7089795918367321 1.1239276562461626 0.2610437175886784 1.0 0.5701402588130837 3 P31751,P62993 2
Rhog gtpase cycle 0.467006168598017 1.1172857134028271 0.2638721820296066 1.0 0.5743602911143691 30 Q13177,Q14126,P02786,Q9Y2U8,P84095,P50402,Q6IAA8,P05556,Q14739 9
Downregulation of erbb2 signaling 0.6990568122578804 1.116322218870639 0.2642842341801881 1.0 0.5743602911143691 6 Q93034 1
Activation of bad and translocation to mitochondria 0.6164834112812896 1.107148019949322 0.2682299368936447 1.0 0.5800637551542366 8 P31751,P27348,P61981 3
Methionine salvage pathway 0.7019124820254938 1.1032701906741322 0.2699098477575661 1.0 0.5817860384561613 4 Q13126 1
Rhoa gtpase cycle 0.4509054659932376 1.0955457054372248 0.2732776333449322 1.0 0.5871233982304662 35 Q15904,O75955,Q12802,Q9UDY2,Q07021,Q96CS3,Q9NQW6,P02786,P28288,Q9H2G2,Q14739,P30519 12
Mhc class ii antigen presentation 0.4302104799424325 1.088060095252016 0.2765685786317262 1.0 0.5871527196268513 43 P10619,Q99538,Q9NSK0,Q9BUF5 4
Glycerophospholipid biosynthesis 0.5056420230909109 1.0880220602982027 0.276585368867744 1.0 0.5871527196268513 18 P35790,Q8IV08 2
Hemostasis 0.3836513768203151 1.06669057901942 0.2861115827055678 1.0 0.5990766145528227 92 P05067,Q14738,Q08380,Q9H4M9,O15439,Q06481,Q13547,P05026,Q9BUF5,P54709,Q8IWA4,Q92896,P05556,O43852,Q9Y624,Q9NSK0,Q07021,P08195,P42785,P84095,P35613 21
Ros and rns production in phagocytes 0.6012745663998889 1.0443751406228592 0.2963118604541399 1.0 0.6126259344083238 8 Q93050,Q9Y487 2
Rhoh gtpase cycle 0.5021258682997802 1.0330456020135432 0.3015825584613325 1.0 0.619747562961597 17 Q13177,Q9BZH6,P02786,Q6IAA8 4
Rho gtpases activate ktn1 0.5963659972982689 1.0241513777291738 0.305763780347779 1.0 0.6243269747566279 8 Q9NSK0 1
Death receptor signalling 0.4999353993714289 1.0214827588060136 0.3070257735338897 1.0 0.6259333494491219 17 Q13501,Q92542,Q12802 3
Sphingolipid de novo biosynthesis 0.5942510345616491 1.0154444121527428 0.3098940316234408 1.0 0.6308043889460149 8 O15269 1
Rho gtpases activate paks 0.5533733797200457 0.999596196738604 0.3175059644533977 1.0 0.6413425693023387 9 Q13177,Q14247,P35579 3
Dna damage reversal 0.6030191758465964 0.9954150852144652 0.3195344247240415 1.0 0.6444515120391464 2 Q6P6C2 1
Pyroptosis 0.6688444262964377 0.9768405396198608 0.3286481025875338 1.0 0.6598011449813751 4 P09429,Q9Y3E7,Q8WUX9 3
Fcgr3a mediated il10 synthesis 0.6647721271054721 0.961379943579992 0.3363611649895317 1.0 0.6663395928957575 4 O43865 1
Diseases of programmed cell death 0.4673455199538709 0.9554829418781692 0.3393335276638516 1.0 0.6680153302440845 20 P05067 1
Hdms demethylate histones 0.6550171919580784 0.9539364422019012 0.3401158154793091 1.0 0.6685560134123136 5 Q8NB78 1
Response of eif2ak1 hri to heme deficiency 0.6583803672399746 0.9279159651186684 0.3534511622275811 1.0 0.6845517362554769 3 P20042 1
Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.6574913347746272 0.9245134034036692 0.3552190762826304 1.0 0.6864022072353549 3 Q14738 1
Cell cell junction organization 0.6091489939076333 0.9240717144345832 0.3554489789935551 1.0 0.6864022072353549 7 Q9Y624 1
Eph ephrin signaling 0.4485232790816377 0.9200789106138356 0.3575315242007528 1.0 0.6881153516260431 23 Q15375,Q92542 2
Signaling by erbb4 0.6076785177977274 0.9183683251299488 0.3584260677414317 1.0 0.6881153516260431 7 Q92542 1
Hdr through single strand annealing ssa 0.5133051026138619 0.9103373266639296 0.3626446390734785 1.0 0.694190391947342 12 Q9UQ84,P54132 2
Synthesis of active ubiquitin roles of e1 and e2 enzymes 0.5313735687516143 0.904595509323432 0.3656797152546094 1.0 0.6987975706640616 9 P49427 1
Adaptive immune system 0.3648108429447423 0.9024470337068756 0.3668194457684659 1.0 0.6987975706640616 153 Q14738,Q9UIQ6,Q92692,Q99538,Q8TBC4,P55786,P60900,P10619,Q9BUF5,Q16763,P05556,P49721,P10321,P61163,P01889,Q03519,P28072,Q9NSK0,P49427,Q93034,Q7Z6Z7 21
Copi independent golgi to er retrograde traffic 0.4491957012053312 0.8970020043048563 0.3697178475149481 1.0 0.6987975706640616 22 Q10472,P61163,Q14203,Q9BUF5,Q10471,Q9UJW0 6
Ion homeostasis 0.509489868372925 0.8927471301007875 0.3719926050049202 1.0 0.6987975706640616 12 P30626,P05026,P54709,O43865,P17612,P23634,P20020 7
Cardiac conduction 0.509489868372925 0.8927471301007875 0.3719926050049202 1.0 0.6987975706640616 12 P30626,P05026,P54709,O43865,P17612,P23634,P20020 7
Gap junction assembly 0.6485009910936244 0.8902121297474309 0.3733519927399427 1.0 0.6987975706640616 3 Q9BUF5 1
Transport of connexons to the plasma membrane 0.6485009910936244 0.8902121297474309 0.3733519927399427 1.0 0.6987975706640616 3 Q9BUF5 1
Activation of ampk downstream of nmdars 0.6485009910936244 0.8902121297474309 0.3733519927399427 1.0 0.6987975706640616 3 Q9BUF5 1
Platelet activation signaling and aggregation 0.4130632368584504 0.8898601302311517 0.3735409944931658 1.0 0.6987975706640616 38 P05067,Q08380,Q06481 3
Ion transport by p type atpases 0.5203327804824983 0.8847145497590582 0.3763106063494827 1.0 0.7003830529191793 10 P30626,Q9HD20,P05026,P54709,P20020 5
Rnd3 gtpase cycle 0.4866628182214282 0.8820484856845352 0.3777505880201492 1.0 0.7003830529191793 15 Q9NYL9,Q14254,Q9Y2I1,O43396,Q9Y2U8,O75976 6
Ripk1 mediated regulated necrosis 0.5189127773779578 0.8784828867193974 0.3796817207576202 1.0 0.7009283455191953 10 O75955,Q13546 2
Homologous dna pairing and strand exchange 0.4991219157222838 0.8743316465945642 0.3819376698031411 1.0 0.703513162420611 13 Q9UQ84,P54132 2
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.5581545938877641 0.8677850852067218 0.3855119964610694 1.0 0.7081161776000395 8 P27348,P61981 2
Notch1 intracellular domain regulates transcription 0.6309036946997305 0.8637458089746182 0.3877275429564881 1.0 0.7102046927311473 5 Q13547,Q92769,Q13573 3
Maturation of sars cov 2 nucleoprotein 0.6299902893988537 0.8600740118519474 0.3897482457682231 1.0 0.7119257138373783 6 P48729,Q99873 2
Rnd2 gtpase cycle 0.4780718873747089 0.8393685008949546 0.401262554156107 1.0 0.7261094565159071 15 Q9Y2U8,O43396,P02786 3
Cell junction organization 0.4780323312331601 0.839172392055306 0.4013725773299774 1.0 0.7261094565159071 15 Q9Y624,Q92692 2
Mitochondrial protein import 0.4214507077239925 0.837189383773622 0.4024861238934463 1.0 0.7271251374042096 32 Q99595,O14925,O96008,O60830,Q8N4H5 5
Dcc mediated attractive signaling 0.5646674826601435 0.8286155356660241 0.4073219941711723 1.0 0.7294634926395304 2 P60953 1
Phosphorylation of emi1 0.5638514891880915 0.8251266483999692 0.4092996919613125 1.0 0.7294634926395304 2 P06493 1
Signaling by notch4 0.3967999173279871 0.8190263764417456 0.412771364932528 1.0 0.733630077754574 40 P28072,P49721,Q92542 3
Ire1alpha activates chaperones 0.439316797853644 0.8161223135604108 0.4144301830578856 1.0 0.7355856483655462 21 Q13217,P61421,O14773,Q9NWM8 4
Signaling by tgfb family members 0.4690072306471198 0.7945412337100886 0.4268804142502054 1.0 0.7476083850631923 15 Q13547,Q9Y624,Q13573 3
Sealing of the nuclear envelope ne by escrt iii 0.6115878674222227 0.7932001951723152 0.4276611938324584 1.0 0.747750780879214 6 P68371,Q9Y3E7,Q9BUF5 3
Interleukin 3 interleukin 5 and gm csf signaling 0.6160984402963757 0.7794980557477744 0.4356863824394787 1.0 0.7565516886268692 4 P62993 1
Cholesterol biosynthesis 0.4846329878350934 0.7789517318295746 0.436008148570838 1.0 0.7565516886268692 12 Q15392,Q9UBM7 2
Antigen processing ubiquitination proteasome degradation 0.3621830627835462 0.7634709464142889 0.4451825829164977 1.0 0.7654118298969027 80 P55786,P49721,P60900,Q9UIQ6,P49427,Q8TBC4,Q93034,Q16763,P28072 9
Rho gtpase cycle 0.3425207457545949 0.7567091492561974 0.4492241322183314 1.0 0.7668513395471808 128 Q5JTV8,Q13177,O96013,P02786,O43396,P28288,O75976,Q96AC1,Q658P3,Q9NYL9,Q15904,O75955,Q9NQW6,Q6IAA8,P05556,P30519,Q12802,Q14126,Q9UQB8,Q9Y2U8,Q14739,Q9BZH6,Q9UDY2,Q07021,Q9Y2I1,A4D1P6,P84095,P50402,Q9UH62,Q96CS3 30
Degradation of the extracellular matrix 0.5652072215786408 0.7557137551839147 0.4498208351936124 1.0 0.7668513395471808 7 Q92542 1
Interconversion of nucleotide di and triphosphates 0.4596376400448136 0.7484804101952359 0.4541704368722061 1.0 0.7717967294976716 15 Q9Y3D8,P04818,P15531,Q16881,P17812,P23919,Q9NRF8,P33316,P00568 9
Clec7a dectin 1 signaling 0.3862828335014267 0.7426111498675642 0.4577171360850451 1.0 0.7742146331631242 43 P28072,P49721,P49427,Q8TBC4 4
Interferon alpha beta signaling 0.5232381799915181 0.7277517630988763 0.4667655574171734 1.0 0.7820995408631265 8 P10321 1
Metabolism of cofactors 0.6004987097248595 0.7227335051757422 0.4698436267393715 1.0 0.7852589548423252 4 O75874 1
Phospholipid metabolism 0.4093896434475977 0.7124612016064431 0.4761792287181219 1.0 0.7911503404805158 26 P35790,Q8IV08 2
Pka activation in glucagon signalling 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Pka mediated phosphorylation of creb 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Creb1 phosphorylation through the activation of adenylate cyclase 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Glucagon signaling in metabolic regulation 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Vasopressin regulates renal water homeostasis via aquaporins 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Aquaporin mediated transport 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Cell cell communication 0.4156721624484004 0.6809238263961561 0.49591969091643 1.0 0.8023880595202925 21 P62993,Q92692,Q9Y5K6,Q9Y624,Q96AC1,P05556 6
Uch proteinases 0.3758752092661932 0.6635878966356096 0.5069541059162912 1.0 0.8153897048762977 44 P28072,Q8NB78,P49721 3
Signaling by tgf beta receptor complex 0.4453119513623891 0.650119480372544 0.5156150468930236 1.0 0.8215292121788241 14 Q9Y624,Q13573 2
Disassembly of the destruction complex and recruitment of axin to the membrane 0.5696472657848175 0.6421097861290016 0.5208019023004065 1.0 0.8215292121788241 5 Q14738 1
Beta catenin phosphorylation cascade 0.5696472657848175 0.6421097861290016 0.5208019023004065 1.0 0.8215292121788241 5 Q14738 1
Signaling by ctnnb1 phospho site mutants 0.5696472657848175 0.6421097861290016 0.5208019023004065 1.0 0.8215292121788241 5 Q14738 1
Rho gtpases activate cit 0.4675341019609638 0.6360350166115959 0.5247535989554404 1.0 0.8237192965724851 9 Q15334,P35579,O43663 3
Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.3961075849073061 0.6301541714161376 0.5285937200215391 1.0 0.8274373194029568 26 Q15185,P61163,Q14203,Q9BUF5,O60884,P68371,Q9UJW0,Q13409,P25685,P63167 10
Cell extracellular matrix interactions 0.5644720917689279 0.626871556958556 0.5307434330565077 1.0 0.8291685662341882 6 Q96AC1,P05556 2
Neurexins and neuroligins 0.5614538727297671 0.616524348311504 0.5375485071612707 1.0 0.8378122886762053 6 Q15334 1
Signaling by erbb2 0.4622928536010144 0.6147493313280656 0.5387202757216518 1.0 0.8386461029851247 9 Q93034,P31751,P62993,P40818 4
C type lectin receptors clrs 0.3682107905379717 0.6060657535096743 0.5444710909697132 1.0 0.8433735633149262 45 P28072,P49721,P49427,Q8TBC4 4
Golgi to er retrograde transport 0.3618684593412153 0.6018582944416468 0.54726846752742 1.0 0.8433735633149262 55 Q10472,Q9BVK6,P49755,Q9BUF5,Q10471,P24390,Q9UJW0,Q9BW19,Q99747,P48444,P61163,Q14203,Q6NUQ1,O95239,P63167,P61923,Q9NSK0,Q9Y678,P35606,P68371,Q02241 21
Unfolded protein response upr 0.382842487936332 0.5995575093547928 0.5488011721798722 1.0 0.8433735633149262 34 P61421,Q9NQT5,Q14203,O14773,Q9NWM8,Q13217,Q9Y2L1,Q15024,O94979,Q9Y3B2 10
Regulation of tp53 activity through phosphorylation 0.4007220208937532 0.5969118756658509 0.5505662180927038 1.0 0.8441013320585019 21 Q9UQ84,P67870,P54132,P38398 4
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.5659073318495962 0.5886706502216773 0.5560822300241357 1.0 0.846935389651883 3 P00374 1
Signaling by interleukins 0.3355770245783689 0.5672301175969046 0.5705578484557803 1.0 0.8540931160231309 95 Q13501,P05067,Q13126,P49721,P60900,P11233,P28072,O00170,O14979,P05556 10
Metalloprotease dubs 0.5560316546028055 0.5669773258806637 0.5707295866556799 1.0 0.8540931160231309 4 P38398 1
Class i mhc mediated antigen processing presentation 0.3310367979457791 0.5659018183266878 0.5714605254244367 1.0 0.8540931160231309 100 P55786,P49721,P60900,Q9UIQ6,P10321,P49427,P01889,Q8TBC4,Q93034,Q03519,Q16763,P28072 12
Sars cov 1 infection 0.43932621935069 0.5597351493767926 0.5756601034727769 1.0 0.8557564836641043 11 Q10472 1
Hdr through homologous recombination hrr 0.4007987462651214 0.5555418198473028 0.5785241138093928 1.0 0.8580138039267684 19 Q9UQ84,P35251,P54132,P38398 4
Post chaperonin tubulin folding pathway 0.5406546040010191 0.5464878341428556 0.5847306481880241 1.0 0.8617063348030182 6 P68371,O75347,Q9BUF5 3
Regulation of tp53 activity through methylation 0.4953080375356988 0.5461837899148827 0.5849396076794975 1.0 0.8617063348030182 2 P04637 1
Fceri mediated nf kb activation 0.3607870691045787 0.5452186435439765 0.585603150560825 1.0 0.8617199433392252 40 P28072,P49721,P49427 3
Sulfur amino acid metabolism 0.443352546340672 0.5392358907927975 0.589724098330747 1.0 0.8658490942046754 9 Q13126 1
Signaling by hippo 0.533193845139895 0.5182478508631468 0.6042853526867715 1.0 0.8823102100759181 5 Q9UDY2 1
Processing of dna double strand break ends 0.3786300251390002 0.505910274478412 0.6129196392005676 1.0 0.8882127492203707 23 Q9UQ84,P38398,P54132,Q9UNS1 4
Activation of nima kinases nek9 nek6 nek7 0.5346938775510158 0.4844113238998487 0.6280939834870467 1.0 0.9020717298281792 3 P06493,P53350 2
Suppression of phagosomal maturation 0.5182804634994044 0.4739913301189009 0.6355060897564302 1.0 0.905332687775783 6 Q14974,Q9H267,P52294 3
Regulation of pten stability and activity 0.3534209007968443 0.4710071864464045 0.6376356029658214 1.0 0.905332687775783 39 P28072,P67870,P49721 3
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.4223601501635701 0.4586091268614516 0.6465148813480854 1.0 0.9116275147060262 9 Q9H9A5,Q9ULM6 2
Plasma lipoprotein assembly 0.4679722562219503 0.4458389732085483 0.6557135673565189 1.0 0.919674939519207 2 P17612 1
Ptk6 regulates proteins involved in rna processing 0.4663402692778542 0.4401072991962247 0.6598593955921845 1.0 0.9221916014246846 2 Q07666 1
Dectin 1 mediated noncanonical nf kb signaling 0.3459532591988221 0.4359933546483931 0.6628415510447025 1.0 0.9221916014246846 40 P28072,P49721,Q8TBC4 3
Tnfr2 non canonical nf kb pathway 0.3459532591988221 0.4359933546483931 0.6628415510447025 1.0 0.9221916014246846 40 P28072,P49721,Q8TBC4 3
Semaphorin interactions 0.3879357957159468 0.4344752161042663 0.6639433883569372 1.0 0.9223770490148592 16 P35579,Q13177,P05556,O75116 4
Carboxyterminal post translational modifications of tubulin 0.5132397919037379 0.4287221528872899 0.6681254371121574 1.0 0.9257658129881698 4 Q9BUF5 1
Perk regulates gene expression 0.4055493882696147 0.422995540619596 0.6722985146349465 1.0 0.9290840963003404 11 Q9NQT5,P20042,Q9Y2L1,Q15024,Q9Y3B2 5
Endosomal sorting complex required for transport escrt 0.5091228659148943 0.4161830737394071 0.6772760445105439 1.0 0.9300124682272848 4 Q8WUX9,Q9Y3E7 2
Transcriptional regulation by e2f6 0.5006289608734862 0.4150804376161578 0.6780830195960248 1.0 0.9300124682272848 5 Q13185,P38398 2
Signaling by vegf 0.3764402429584792 0.4116766043142673 0.6805764753082761 1.0 0.9300124682272848 18 O43865,Q9UQB8,P31751,P42345 4
Intrinsic pathway for apoptosis 0.391414352878027 0.4088492081978999 0.6826503252023102 1.0 0.9300124682272848 14 P31751,P27348,Q07021 3
Rap1 signalling 0.5097959183673421 0.4067911110921197 0.6841614158596787 1.0 0.9300124682272848 3 P63104,P17612 2
Signaling by wnt in cancer 0.4629207418179922 0.3962403944438581 0.6919276943695045 1.0 0.9300124682272848 7 Q14738 1
Rho gtpases activate iqgaps 0.4331391276294909 0.394291376070744 0.6933659295619996 1.0 0.9300124682272848 8 Q9BUF5 1
Protein ubiquitination 0.3605325072054683 0.3913794701359968 0.6955167649966902 1.0 0.9300124682272848 22 P49427,Q14527 2
Diseases associated with n glycosylation of proteins 0.4508363933088508 0.3872816517774059 0.6985477075211273 1.0 0.9300124682272848 2 O75340 1
Deactivation of the beta catenin transactivating complex 0.4872293149680959 0.3793508294044574 0.7044273589292942 1.0 0.9300124682272848 6 P31751 1
E2f enabled inhibition of pre replication complex formation 0.4483884128927067 0.3792218548720974 0.7045231236678222 1.0 0.9300124682272848 2 P06493 1
Flt3 signaling 0.4956407372162369 0.3652359906543039 0.7149352545956775 1.0 0.9372295595480504 3 P31751 1
Copi dependent golgi to er retrograde traffic 0.3434776065320875 0.3586841833839368 0.7198313619481116 1.0 0.9414279083273714 36 Q9NSK0,Q9BW19,P49755,Q9Y678,Q9BUF5,Q02241,P24390,P35606,Q6NUQ1,P68371,O95239,Q9BVK6,Q99747,P48444,P61923 15
Translation of sars cov 2 structural proteins 0.3678837998390782 0.356692736261595 0.7213218439483233 1.0 0.942044456107304 17 Q99873 1
Sars cov 2 infection 0.3555764924569494 0.355287278324236 0.7223743850282047 1.0 0.942044456107304 21 Q10472,Q9Y3E7,Q99873 3
Prolactin receptor signaling 0.4406364749081971 0.3542334097143715 0.7231639674445591 1.0 0.942044456107304 2 P63208 1
Fbxw7 mutants and notch1 in cancer 0.4406364749081971 0.3542334097143715 0.7231639674445591 1.0 0.942044456107304 2 P63208 1
Kinesins 0.3801486581397119 0.34788418058062 0.7279271661767894 1.0 0.9432692737339036 13 Q9NSK0,Q9BUF5,P68371,O95239,Q9BW19,Q02241 6
Ksrp khsrp binds and destabilizes mrna 0.3915443586310768 0.3477118355857891 0.7280566071757542 1.0 0.9432692737339036 9 Q9Y2L1,Q15024,Q9Y3B2 3
Mrna decay by 3 to 5 exoribonuclease 0.3816514890574796 0.3421749867233443 0.7322192080333751 1.0 0.9432692737339036 12 Q9NQT5,Q9Y2L1,Q15024,Q96C86,Q9Y3B2 5
Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.4171343925459544 0.3418708969415889 0.7324480523174621 1.0 0.9432692737339036 8 Q9Y2L1,Q15024,Q9Y3B2 3
Intraflagellar transport 0.416891540245649 0.3410965792040028 0.7330308763772893 1.0 0.9432692737339036 8 Q9BW83,P68371,A0AVF1,Q9BUF5 4
Anchoring of the basal body to the plasma membrane 0.3458425608917454 0.3356676088418372 0.7371215343672732 1.0 0.9452668556589084 25 P61981,Q15019,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P68371,P17612,P63167,O94927 12
Atf4 activates genes in response to endoplasmic reticulum stress 0.3843987026933519 0.3235084103495307 0.7463102391537126 1.0 0.9514913697632522 9 Q9NQT5,Q9Y2L1,Q15024,Q9Y3B2 4
Butyrate response factor 1 brf1 binds and destabilizes mrna 0.4383590271322634 0.3215650572878117 0.7477822191010861 1.0 0.9524460179459676 7 Q9Y2L1,Q15024,Q9Y3B2 3
Tcr signaling 0.328769840690661 0.3098889873303587 0.7566453776938324 1.0 0.9587586546322164 43 P28072,P49721,P49427 3
Tp53 regulates transcription of death receptors and ligands 0.4247246022031832 0.3056176442235293 0.7598957847293344 1.0 0.9587586546322164 2 P04637 1
Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.4247246022031796 0.3056176442235185 0.7598957847293426 1.0 0.9587586546322164 2 O00767 1
Antigen presentation folding assembly and peptide loading of class i mhc 0.3585871108724431 0.3054107426859072 0.7600533409263348 1.0 0.9587586546322164 16 P04439,P10321,Q6P179,P01889,Q03519 5
Phosphorylation of the apc c 0.3786787006535645 0.304594508060018 0.7606750033180554 1.0 0.9587586546322164 9 Q16763 1
Recruitment of mitotic centrosome proteins and complexes 0.3401165079532412 0.3044092907263687 0.7608160904779588 1.0 0.9587586546322164 25 P61981,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P68371,P17612,P63167,O94927 11
Fc epsilon receptor fceri signaling 0.3272433495202826 0.2984832624075517 0.7653343489062983 1.0 0.9598370195639792 44 P28072,P49721,P49427 3
Cooperation of prefoldin and tric cct in actin and tubulin folding 0.3562126969239911 0.2801299674406077 0.7793777940469957 1.0 0.9710885097066162 15 Q99471,Q9UHV9,Q9BUF5 3
Tp53 regulates transcription of cell cycle genes 0.3555967387483976 0.2776989097693554 0.7812434975708378 1.0 0.9724930872408254 15 Q9H9A5,Q9ULM6,Q99873 3
G2 m dna damage checkpoint 0.3353775711544534 0.2733265750156938 0.7846021888930359 1.0 0.9751874777487934 30 Q9UQ84,P54132,P27348,P38398 4
Rho gtpases activate wasps and waves 0.3567549976081624 0.2522902041602397 0.8008167592474731 1.0 0.9866002543769148 12 Q9UQB8 1
Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.3858818213621582 0.2480043096741986 0.8041310723168402 1.0 0.9897575908796996 8 Q16763 1
Recruitment of numa to mitotic centrosomes 0.3294233267228629 0.239924096869886 0.8103890997690602 1.0 0.9937452927335684 28 P61981,Q15154,P61163,Q14203,Q7Z460,Q9BUF5,Q15691,P07437,P68371,P17612,P63167,O94927 12
Collagen biosynthesis and modifying enzymes 0.3528748157011913 0.2342008669282475 0.8148290420218083 1.0 0.9973325728092208 11 O60568,P13674,O15460 3
Apc c cdc20 mediated degradation of cyclin b 0.3803676214370223 0.2327450711167051 0.8159593684334199 1.0 0.9977887541567448 8 Q16763 1
Phenylalanine and tyrosine metabolism 0.4430074359403043 0.2301192329599209 0.8179991201601227 1.0 0.9983610440035248 3 P16930 1
The phototransduction cascade 0.4419716658888233 0.2277983909201143 0.8198029776719193 1.0 0.9983610440035248 3 P49356 1
Regulation of bach1 activity 0.4408163265306078 0.2252260002591238 0.8218034637362872 1.0 0.9993676470366484 3 Q13309,P63208 2
Sema4d in semaphorin signaling 0.4011019866448627 0.2209310912582701 0.825146088200639 1.0 1.0 7 P35579,O75116 2
Signaling by receptor tyrosine kinases 0.3065803800516128 0.2196270456438613 0.8261616262695717 1.0 1.0 81 Q13547,Q14738,Q15904,P11233,Q9UQB8,Q9Y487,Q93034,P31751,Q92542,Q93050,Q15334,P05556 12
Regulation of plk1 activity at g2 m transition 0.324536488825431 0.2186937981155082 0.8268885804404837 1.0 1.0 26 P68371,P61981,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P63208,Q13409,P17612,P63167,O94927 13
Vegfr2 mediated vascular permeability 0.348286676406898 0.2116999481082256 0.8323411285860787 1.0 1.0 9 P31751,P42345 2
The role of gtse1 in g2 m progression after g2 checkpoint 0.3139734878930079 0.2056557042991054 0.8370598617046869 1.0 1.0 45 P28072,P60900,P49721 3
Assembly and cell surface presentation of nmda receptors 0.3698388327565067 0.2047891823577618 0.8377368391267692 1.0 1.0 8 Q9BUF5 1
Glucagon like peptide 1 glp1 regulates insulin secretion 0.4238464679461092 0.1959484315184425 0.8446505291113835 1.0 1.0 4 P17612,P10644,P13861 3
Extra nuclear estrogen signaling 0.3904799274177647 0.1954035527768051 0.8450770355085369 1.0 1.0 7 Q99873 1
Rho gtpases activate rocks 0.3887014373872738 0.1912762339720971 0.8483091798612341 1.0 1.0 7 P35579,O75116 2
Negative regulators of ddx58 ifih1 signaling 0.4209881584320214 0.190061708617787 0.84926077520407 1.0 1.0 4 Q96J02,Q14258,P61086 3
Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.3876094393232634 0.1887632395489358 0.8502783844179831 1.0 1.0 7 Q16763 1
Downregulation of smad2 3 smad4 transcriptional activity 0.4101725342468422 0.1844202583377359 0.8536837785223836 1.0 1.0 6 Q13573 1
Transcriptional activity of smad2 smad3 smad4 heterotrimer 0.4101725342468422 0.1844202583377359 0.8536837785223836 1.0 1.0 6 Q13573 1
Parasite infection 0.3307167405360552 0.1772965150083172 0.859275488052744 1.0 1.0 14 Q9UQB8 1
Sema4d induced cell migration and growth cone collapse 0.403537259461147 0.1708256853548497 0.8643608319318308 1.0 1.0 6 P35579,O75116 2
Muscle contraction 0.3139526888649427 0.1677935062926162 0.86674573129838 1.0 1.0 23 Q9NYL9,P30626,Q13177,P05026,P54709,O43865,P17612,P23634,P20020 9
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.308241300000436 0.1671875688763772 0.8672224653537994 1.0 1.0 45 P28072,P60900,P49721 3
Regulation of runx3 expression and activity 0.3126975630426758 0.1606198960111821 0.8723927836114256 1.0 1.0 35 P28072,P49721 2
Josephin domain dubs 0.3647490820073473 0.1588958758320209 0.8737509100247045 1.0 1.0 2 P54727 1
Aurka activation by tpx2 0.3102718056794354 0.1575983587266315 0.8747732969570587 1.0 1.0 24 P61981,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P68371,P17612,P63167,O94927 11
Hiv transcription initiation 0.346286249075286 0.1481803378969624 0.8822004485909052 1.0 1.0 8 P29083 1
Signaling by alk in cancer 0.3112575261571239 0.1456344845969564 0.8842099434328499 1.0 1.0 28 Q13501 1
Rhod gtpase cycle 0.3105638402932528 0.145050992677528 0.8846706111429974 1.0 1.0 21 Q9Y2U8,P50402,Q14739,Q658P3 4
Met promotes cell motility 0.3895552770810777 0.1427083415810583 0.8865205285244036 1.0 1.0 5 P05556 1
Diseases of mismatch repair mmr 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 1.0 3 P52701,P20585 2
Prevention of phagosomal lysosomal fusion 0.3942857142857078 0.1364133387148274 0.8914945294782697 1.0 1.0 3 P51149,Q9H267 2
Cross presentation of soluble exogenous antigens endosomes 0.3068420786553162 0.1326740565172362 0.894451161349904 1.0 1.0 36 P28072,P49721 2
Degradation of axin 0.3068420786553162 0.1326740565172362 0.894451161349904 1.0 1.0 36 P28072,P49721 2
Runx1 interacts with co factors whose precise effect on runx1 targets is not known 0.3174728586695727 0.1306299351578642 0.8960680608010514 1.0 1.0 11 P67870 1
Transcriptional regulation by runx3 0.3022265947617545 0.1283026872933131 0.8979094385315787 1.0 1.0 39 P28072,P60900,Q13573,P49721 4
Pkmts methylate histone lysines 0.379604962188919 0.1264589680927745 0.8993686269546528 1.0 1.0 6 Q9H7B4 1
Stabilization of p53 0.3036108249254438 0.1203892661960526 0.9041747938938314 1.0 1.0 37 P28072,P49721 2
Negative regulation of notch4 signaling 0.3016744310292215 0.1163970148896906 0.9073379010876732 1.0 1.0 38 P28072,P49721 2
Rna polymerase iii transcription initiation from type 3 promoter 0.3788444829146558 0.1158140840097972 0.907799888204041 1.0 1.0 4 O14802,O15160 2
Rna polymerase iii chain elongation 0.3788444829146558 0.1158140840097972 0.907799888204041 1.0 1.0 4 O14802,O15160 2
Cdt1 association with the cdc6 orc origin complex 0.3023951381450444 0.1134466134389044 0.9096764860368158 1.0 1.0 37 P28072,P49721 2
Interleukin 12 signaling 0.3041315076757106 0.1109847031156765 0.9116284769322428 1.0 1.0 28 P11233,Q13126,O00170,O14979 4
Metabolism of polyamines 0.3011627624154736 0.1064584021249406 0.915218658091427 1.0 1.0 37 P28072,P49721 2
Homology directed repair 0.3021565252430717 0.1020269175538224 0.9187353094473594 1.0 1.0 35 Q9UQ84,P38398,P54132,Q9UNS1 4
Formation of tubulin folding intermediates by cct tric 0.3058968058968059 0.1016676796797262 0.9190204570576176 1.0 1.0 11 P50990,P50991,P17987,P78371,Q9BUF5,Q9BVA1,P68371,P49368,P48643,Q99832 10
Pentose phosphate pathway 0.3627602815447608 0.0996858266923257 0.9205937531496556 1.0 1.0 6 O95336 1
Ras processing 0.3663366970002756 0.098320696835425 0.9216776441068028 1.0 1.0 4 P49356 1
Asymmetric localization of pcp proteins 0.2989918614197332 0.0942723104910253 0.9248928449638928 1.0 1.0 37 P28072,P49721 2
Downstream signaling events of b cell receptor bcr 0.2976381605298093 0.0931436757346356 0.9257894200119696 1.0 1.0 38 P28072,P49721 2
Regulation of hmox1 expression and activity 0.2953124103685024 0.0862368609048021 0.9312781290734872 1.0 1.0 44 P28072,P67870,P49721 3
Sumoylation of transcription factors 0.3542857142857091 0.0833295338490164 0.9335895173371478 1.0 1.0 3 Q12888,P04637 2
Regulation of runx2 expression and activity 0.2933644244064713 0.0818945065206797 0.9347306029284616 1.0 1.0 41 P28072,P49721 2
Degradation of dvl 0.2955919789248261 0.0755137808832646 0.9398059332840438 1.0 1.0 37 P28072,P49721 2
Regulation of ras by gaps 0.2955919789248261 0.0755137808832646 0.9398059332840438 1.0 1.0 37 P28072,P49721 2
Nephrin family interactions 0.3449121373109974 0.0753225686834132 0.9399580652742454 1.0 1.0 6 P12814,Q13813,P46940,Q9Y5K6,O43707 5
Interaction between l1 and ankyrins 0.3444897959183621 0.073443769850901 0.9414529883137496 1.0 1.0 3 Q13813,Q12955 2
Ncam signaling for neurite out growth 0.3444897959183612 0.0734437698509005 0.94145298831375 1.0 1.0 3 Q13813,P62993 2
Wnt5a dependent internalization of fzd2 fzd5 and ror2 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4
Wnt5a dependent internalization of fzd4 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4
Nef mediated cd8 down regulation 0.3406862745098056 0.0718194608427406 0.9427455852993872 1.0 1.0 5 O95782,Q96CW1,Q9UI12,P63010 4
Vldlr internalisation and degradation 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4
Nef mediated cd4 down regulation 0.3406862745098056 0.0718194608427406 0.9427455852993872 1.0 1.0 5 O95782,Q96CW1,Q9UI12,P63010 4
Retrograde neurotrophin signalling 0.3408255006129942 0.0703139247730215 0.9439437995731396 1.0 1.0 6 P63010,P50570,Q00610,O95782,Q96CW1 5
Collagen formation 0.2938631768032457 0.0692797215828344 0.9447669667815152 1.0 1.0 13 O60568,P13674,O15460 3
Rna polymerase iii transcription termination 0.3346806899317542 0.0652325210300963 0.9479888682247388 1.0 1.0 5 O14802,P19388,O15160 3
Signaling by notch 0.2929577236055524 0.0651785045705841 0.9480318755980646 1.0 1.0 51 P60900,P49721,Q92542,Q13573,P28072 5
Sumo is transferred from e1 to e2 ube2i ubc9 0.2774377804977499 0.0527514303751163 0.9579299605248262 1.0 1.0 2 Q9UBT2 1
Processing and activation of sumo 0.2774377804977499 0.0527514303751163 0.9579299605248262 1.0 1.0 2 Q9UBT2 1
Sumo is conjugated to e1 uba2 sae1 0.2774377804977499 0.0527514303751163 0.9579299605248262 1.0 1.0 2 Q9UBT2 1
Biosynthesis of specialized proresolving mediators spms 0.2753977968176189 0.0515608484154753 0.9588786162584692 1.0 1.0 2 P09960 1
Synthesis of leukotrienes lt and eoxins ex 0.2753977968176189 0.0515608484154753 0.9588786162584692 1.0 1.0 2 P09960 1
Aggrephagy 0.2814420319541107 0.0445443035586 0.9644705378706292 1.0 1.0 12 P61088,P08670,Q9BUF5,Q14204,Q9BVA1,P55072,P68371,Q13409,P07900,Q9Y6G9,P63167 11
Trafficking of glur2 containing ampa receptors 0.3092320261437931 0.0420639029661398 0.966447755947671 1.0 1.0 5 O95782,O94973,Q96CW1,P63010 4
Response of mtb to phagocytosis 0.2717969709373735 0.0381788753977883 0.9695450636048204 1.0 1.0 10 P00558,P49840,P51149,Q9UI12,P20339,Q9H267,Q14974,P23246,P52294 9
Infection with mycobacterium tuberculosis 0.2717969709373735 0.0381788753977883 0.9695450636048204 1.0 1.0 10 P00558,P49840,P51149,Q9UI12,P20339,Q9H267,Q14974,P23246,P52294 9
Circadian clock 0.3085410706988165 0.0378355070258407 0.9698188341175646 1.0 1.0 6 Q86X55,P63208,Q9BWF3,Q13616,P43490 5
Initiation of nuclear envelope ne reformation 0.2805215947933772 0.0355124054319476 0.9716711545112452 1.0 1.0 15 Q9Y2U8,Q14739 2
Regulation of tp53 activity 0.2895575735905982 0.0346536091370161 0.9723559532340198 1.0 1.0 33 Q9UQ84,P67870,Q92804,P31751,P54132,P38398 6
Signaling by ntrk2 trkb 0.2653061224489735 0.0292052986439975 0.976700855330904 1.0 1.0 3 P63000,P62993 2
G1 s specific transcription 0.2703476482617513 0.0254583184467974 0.9796893947628074 1.0 1.0 8 Q13547,P06493,P04818,Q9Y619,P12004,P04183,P00374 7
Degradation of gli1 by the proteasome 0.2825967798236318 0.0236945903709991 0.9810962210544658 1.0 1.0 40 P28072,P49721 2
Cytosolic iron sulfur cluster assembly 0.2844527245792713 0.0210718304994208 0.9831883559092822 1.0 1.0 6 Q6FI81 1
Chrebp activates metabolic gene expression 0.2540849673202636 0.013851084830027 0.9889487866321264 1.0 1.0 5 Q99943,P53396,P49327,O00763 4
Protein folding 0.2804902989711575 0.0070825996513248 0.9943489503337056 1.0 1.0 28 P67870,Q15477,Q9UHV9,Q9BUF5,Q99471,P04062,P68371 7