term
stringlengths
2
121
overlap
int64
6
281
setsize
int64
7
499
score
float64
1.96
10.6
pval
float64
0
0.05
edge
stringlengths
41
1.97k
type
stringclasses
5 values
subtype
stringclasses
24 values
subtype_key
stringclasses
24 values
edge_idxs
stringlengths
11
1.17k
ann_idxs
stringlengths
19
2.31k
ann_vals
stringlengths
124
9.94k
sig_size
int64
2.2k
3.73k
Lipid biosynthesis
34
62
3.089673
0.002004
Q15738,Q16850,P37268,Q9H7Z7,Q92604,Q86UL3,O00767,Q15125,Q9BY49,Q15392,O14735,Q15800,Q9NZ01,Q9HCL2,Q8NBQ5,Q96G23,O95864,P27544,Q9BVG9,Q14739,Q6UWP7,P00387,Q9UBM7,P48651,O95674,Q9P035,Q9NUQ2,Q8WUK0,Q96N66,Q8NF37,O75845,Q9UG56,Q8WVX9,Q53GQ0
Processes and pathways
Protein Atlas Biological process
protein_atlas_biological_process
387,134,135,137,267,529,154,29,546,160,414,165,38,426,424,42,432,53,311,189,450,455,589,206,344,217,352,478,350,222,226,357,620,252
807,3269,154,414,226,344,432,455,3280,779,53,853,135,3194,624,206,1511,1340,2436,959,2413,1247,3277,1342,2856,189,29,2703,1951,160,387,165,134,252,450,1734,529,2724,424,222,478,620,3212,267,1020,42,350,704,3242,311,2590,546,1254,137,426,1971,352,38,217,589,357,1418
0.48368248830757804,-3.146767552195213,1.9144437606804396,1.1781166331105064,1.6737570165263596,1.3754950960188768,1.1257225867100962,1.0629230876732314,-6.107905474939424,0.5303006348287622,2.3917548675348224,0.4361245796717036,1.9844356939482424,-1.7447314974541128,0.7503052990808158,1.7466222698245972,-0.03993330241...
3,282
Lytic vacuole organization
11
22
3.085082
0.002035
P10253,P54802,Q6IAA8,P11117,P50897,O14773,O75503,O75787,Q14108,P04062,Q8N511
Processes and pathways
GO Biological process
msigdb_gobp
448,544,487,337,113,245,185,476,59,508,30
2094,245,185,476,1011,508,996,448,337,970,113,986,544,1064,1317,59,487,30,1050,1273,657,1585
-0.3656904426873758,1.6050478734418685,1.8168100809967223,1.0075968998317675,0.3002316049038404,0.9508251925691111,0.31290751003911416,1.0810543153942933,1.3911217484186955,0.3380617261470323,2.084626278586148,0.3255173624134485,0.8826800662358034,0.26180182929916834,0.07405392309687711,2.3643180638763854,0.98883665308...
3,282
Regulation of ph
12
21
3.082047
0.002056
Q9Y487,P06576,Q15904,Q93050,P50897,P51790,Q8TDJ6,Q92581,Q9Y6M7,O75503,O75787,Q8N511
Processes and pathways
GO Biological process
msigdb_gobp
96,393,297,78,113,338,499,568,440,185,476,30
185,476,1011,393,2295,113,986,338,899,297,30,499,621,568,78,1050,1874,1008,96,2074,440
1.8168100809967223,1.0075968998317675,0.3002316049038404,1.2376437411982282,-0.46667678351272657,2.084626278586148,0.3255173624134485,1.383323389818909,0.39982049717194035,1.489859568534655,2.6003028144867857,0.9699135301639633,0.7607694437360165,0.8427770525503605,2.2150673707781547,0.27467934583159376,-0.236747418083...
3,282
Regulation of cellular ph
12
21
3.082047
0.002056
Q9Y487,P06576,Q15904,Q93050,P50897,P51790,Q8TDJ6,Q92581,Q9Y6M7,O75503,O75787,Q8N511
Processes and pathways
GO Biological process
msigdb_gobp
96,393,297,78,113,338,499,568,440,185,476,30
185,476,1011,393,2295,113,986,338,899,297,30,499,621,568,78,1050,1874,1008,96,2074,440
1.8168100809967223,1.0075968998317675,0.3002316049038404,1.2376437411982282,-0.46667678351272657,2.084626278586148,0.3255173624134485,1.383323389818909,0.39982049717194035,1.489859568534655,2.6003028144867857,0.9699135301639633,0.7607694437360165,0.8427770525503605,2.2150673707781547,0.27467934583159376,-0.236747418083...
3,282
Slc mediated transmembrane transport
17
21
3.081426
0.00206
P30825,P53985,Q9Y289,Q9UBX3,Q9H2J7,P35613,P05141,Q15758,Q92581,P08195,Q9Y6M7,Q8TB61,Q70HW3,P55011,P12236,P11166,P12235
Processes and pathways
Reactome Pathways
msigdb_reactome
260,452,648,101,268,269,369,716,568,661,440,116,119,473,246,727,283
369,661,727,283,246,2932,260,269,2407,452,473,716,1465,119,116,568,268,806,101,648,440
1.3036615500505515,0.6756749018671949,0.5872975874697021,1.5192895851287898,1.6050478734418685,-1.0360707487667298,1.5768737308442182,1.5554754645247586,-0.5361680162076139,1.072007814174242,1.0169166628653525,0.5985313967053411,-0.010951106844849056,2.0683095696483034,2.0737649857143774,0.8427770525503605,1.5626340143...
3,282
Steroid metabolic process
28
71
3.074776
0.002107
Q15738,Q16850,P37268,Q9BQE5,O95470,P35610,Q15125,Q15392,Q15800,Q8NBQ5,Q13510,P16435,Q14739,Q14849,P00387,P38571,P05023,P30536,Q14534,P28288,O75845,Q8WTV0,P05067,Q6IAA8,O15118,P38435,O75477,Q53GQ0
Processes and pathways
GO Biological process
msigdb_gobp
387,134,135,10,139,412,29,160,165,424,173,303,189,190,455,457,329,210,92,481,226,228,364,487,496,121,507,252
660,496,507,226,1384,139,455,3262,508,329,364,3230,851,779,2998,303,1981,2621,3122,3249,481,210,412,135,121,457,3181,624,2348,2973,1094,1340,2436,2411,1697,2413,1247,1601,1342,173,2856,92,189,190,1434,29,2703,160,1285,2415,387,165,134,252,682,487,424,228,3212,1841,932,3119,10,2590,1254,1558,589,1562,908,1418,2917
0.6756749018671949,0.9699135301639633,0.9508251925691111,1.6737570165263596,0.03190983674591957,1.9671862750973885,1.0629230876732314,-2.838927731781795,0.9508251925691111,1.4143390826722653,1.311767990032626,-2.0807350398561413,0.4361245796717036,0.5303006348287622,-1.1431342104617603,1.4749805289162001,-0.30043120400...
3,282
Outer mitochondrial membrane protein complex
13
17
3.067805
0.002156
Q9Y512,Q8N4H5,Q9BUR5,Q9NS69,Q16891,Q6UXV4,O96008,Q9NX63,Q13505,Q15388,O75431,Q8IWA4,Q5XKP0
Localization
GO Cellular component
msigdb_gocc
289,2,354,3,384,327,522,588,150,214,536,409,223
536,1910,522,2435,150,214,384,759,223,327,409,2,354,3,604,588,289
0.8925447943651219,-0.26839630877418835,0.9218776772216002,-0.5538222763019724,1.9380715708648737,1.7204443365870585,1.2709146386099495,0.553266773259591,1.6804961885566763,1.4220195620215796,1.2038349263436867,3.077775267780019,1.3518287006792393,3.048292378060906,0.7815534582639972,0.8021475154954494,1.51197267528796...
3,282
Organelle localization
49
172
3.065952
0.00217
O95140,Q9UH99,Q9BVK6,P09601,Q9BZG1,P16615,A0FGR8,Q8TD16,Q8IWA4,Q13561,Q92734,Q96DB5,Q15907,P05556,O94901,P49755,Q9UH62,Q13190,Q96A57,O43865,P11279,Q14849,P61026,Q86U38,Q9BSJ8,Q9Y6B6,O75153,Q86Y82,Q5SNT2,Q9NR31,P33176,O75381,O95772,Q658Y4,O60499,O75340,Q12846,Q15363,Q9UNK0,Q9H267,O15400,Q6IAA8,P62820,Q9BZH6,O14964,Q9HCU...
Processes and pathways
GO Biological process
msigdb_gobp
640,385,519,5,657,146,530,665,409,672,549,550,171,554,302,177,562,307,54,442,445,190,447,320,712,197,200,708,331,208,592,209,85,601,88,117,608,231,494,492,361,487,625,627,630,633,634,122,251
530,1878,2341,2614,2094,808,1037,2556,1359,2777,630,2168,1642,361,1564,1743,1242,2006,442,1010,967,251,88,1399,200,117,209,2647,302,640,1077,1011,85,1204,554,1772,1227,5,445,1402,798,146,1090,3154,3108,2866,592,1208,1312,2013,970,2519,2102,2015,2299,1061,2489,177,1313,986,1387,927,2322,3210,2911,1775,447,2962,2674,1109...
0.9023657605473742,-0.2525240921368897,-0.5011996135687354,-0.6993023365480029,-0.3656904426873758,0.48368248830757804,0.27467934583159376,-0.6438434670471683,0.046036537625815596,-0.833163298717403,0.739792573336865,-0.3989310648369808,-0.11386315525085984,1.319842728048399,-0.06924930006218029,-0.17457749746050444,0....
3,282
Abnormal glycosylation
12
23
3.063247
0.002189
Q9Y487,Q9BT22,P51571,Q9UKM7,Q15904,Q9H0U3,Q2TAA5,P46977,P36543,O75340,O75787,Q8N511
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
96,224,446,229,297,273,429,205,276,117,476,30
2995,1362,117,476,649,1983,276,2670,2264,1188,205,446,928,297,429,30,491,2589,224,273,229,2161,96
-1.1431342104617603,0.046036537625815596,2.0683095696483034,1.0075968998317675,0.6972483592523054,-0.3004312040094234,1.5338431920449878,-0.7368998001778377,-0.4495795537981615,0.16971055420918638,1.7466222698245972,1.0900628551110845,0.3753074270564578,1.489859568534655,1.1345451882132496,2.6003028144867857,0.98883665...
3,282
Protein transporter activity
13
16
3.061797
0.0022
Q9NS69,O60830,Q99595,Q9Y584,Q8NBU5,O96008,Q9HD20,O14925,Q9UGP8,P49755,Q07820,Q15388,P61619
Functions
GO Molecular function
msigdb_gomf
3,6,7,39,517,522,141,204,464,177,306,214,381
204,6,1910,522,177,2960,381,306,214,517,7,141,3,464,39,575
1.7466222698245972,2.871229479114277,-0.26839630877418835,0.9218776772216002,1.8540228866330113,-1.0784257883650035,1.2791499570584708,1.459990344325287,1.7204443365870585,0.9315692547952261,2.8577394320847582,1.9671862750973885,3.048292378060906,1.0446378908949554,2.5057002573399854,0.8326886240854579
3,282
Steroid biosynthetic process
18
48
3.046914
0.002312
Q15392,P28288,O75845,Q15738,Q15800,Q16850,P37268,P00387,Q8NBQ5,P05023,Q13510,P16435,P30536,Q14739,Q14534,Q53GQ0,Q15125,Q14849
Processes and pathways
GO Biological process
msigdb_gobp
160,481,226,387,165,134,135,455,424,329,173,303,210,189,92,252,29,190
660,507,226,1384,455,329,851,779,2998,303,1981,2621,3122,481,210,135,3181,624,1340,2436,2413,1247,1342,173,2856,92,189,190,29,2703,160,1285,2415,387,165,134,252,424,3212,1841,932,3119,2590,1254,1558,589,908,1418
0.6756749018671949,0.9508251925691111,1.6737570165263596,0.03190983674591957,1.0629230876732314,1.4143390826722653,0.4361245796717036,0.5303006348287622,-1.1431342104617603,1.4749805289162001,-0.3004312040094234,-0.6993023365480029,-1.4171054761327109,0.9982369916254527,1.7335780386025421,1.9844356939482424,-1.64018635...
3,282
Inorganic anion transmembrane transporter activity
13
19
3.045474
0.002323
O43826,Q02978,Q9UBX3,Q9NW15,Q9Y277,P45880,P51790,Q9Y6M7,Q4KMQ2,Q8IWT6,P55011,P21796,Q9C0H2
Functions
GO Molecular function
msigdb_gomf
290,502,101,75,144,50,338,440,183,602,473,27,125
2820,983,290,27,50,338,607,473,502,183,718,602,1155,125,75,101,144,2074,440
-0.8726078477761282,0.3255173624134485,1.504628811917597,2.608273403896568,2.4276537777883638,1.383323389818909,0.7711853753910292,1.0169166628653525,0.9603901611793697,1.835508625996173,0.5985313967053411,0.7815534582639972,0.1963764809799616,2.0407814601804124,2.249917990435712,2.1274228131219526,1.9614001548957578,-...
3,282
Abnormal circulating cholesterol concentration
20
38
3.033998
0.002413
Q9NVI7,Q15738,P37268,Q9BTV4,P50402,Q9UJS0,O75431,Q15125,Q8N511,Q15392,O43826,Q15800,Q15904,Q9NZJ7,Q14739,Q9BV10,Q9Y6B6,P38571,P07602,O75845
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
259,387,135,396,147,534,536,29,30,160,290,165,297,180,189,68,197,457,461,226
2995,290,536,226,3262,1204,1131,461,135,457,2102,2213,147,2982,737,2411,1095,928,831,1546,189,29,160,387,165,297,682,3215,30,1138,396,68,3078,259,180,589,534,197
-1.1431342104617603,1.504628811917597,0.8925447943651219,1.6737570165263596,-2.838927731781795,0.15626881809147214,0.2096019534829797,1.0446378908949554,1.9844356939482424,1.0629230876732314,-0.3656904426873758,-0.4157078025838387,1.9497728756171566,-1.1214054169329557,0.5760091732007232,-0.5361680162076139,0.235841062...
3,282
Lysosomal lumen
24
34
4.569965
0.000005
P15586,Q14108,P04062,Q9UMR5,Q8NHP8,P50897,Q9NZJ7,Q13510,P16278,P38435,P07858,P06280,P54802,Q8IV08,P04066,P10619,P07686,P07602,O14773,O00584,P38571,P11117,P06865,P17900
Localization
GO Cellular component
msigdb_gocc
258,3,145,42,40,44,301,46,54,55,53,184,185,59,322,72,335,209,81,212,100,103,113,246
212,81,639,145,322,184,113,209,335,53,831,854,372,72,103,1942,723,1731,258,54,246,55,100,44,185,840,46,3,59,3095,40,992,301,42
1.5588097511325756,2.4255716705252155,0.6252443929676549,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,1.5805666593769274,1.1386619873046315,2.712662399939541,0.4447751115533682,0.4292836766633106,1.0500310352209634,2.537625343517015,2.283382339582687,-0.25685057969960273,0.5362387937640063...
3,282
Membrane lipid metabolic process
20
35
4.315956
0.000016
O15269,O95470,P04062,P30153,Q8NCC3,Q8NBX0,P27544,P50897,Q9NZJ7,Q13510,P16278,O43292,P06280,P04066,P07602,Q99805,Q96G23,P06865,P17900,Q06136
Processes and pathways
GO Biological process
msigdb_gobp
257,133,145,275,23,28,37,44,301,46,54,311,184,322,209,84,90,113,246,120
257,1380,311,578,133,145,322,184,113,209,335,54,246,1990,37,275,44,120,1313,46,2222,448,28,23,608,573,90,769,84,803,1376,1689,301,527,1849
1.390559620323408,0.05173904046404934,1.2004894005422622,0.6976210318395957,2.0236236192967936,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,1.5805666593769274,1.1386619873046315,2.712662399939541,1.4249475180109552,-0.27588668305362396,2.8913413666749483,1.3088165399463132,2.86350990941192...
3,282
Sphingolipid metabolic process
17
27
3.976758
0.00007
O15269,O95470,P27544,P50897,Q9NZJ7,Q13510,P04062,P07602,P30153,Q99805,P16278,P06865,Q8NCC3,P06280,P17900,Q96G23,Q06136
Processes and pathways
GO Biological process
msigdb_gobp
257,133,37,44,301,46,145,209,275,84,54,113,23,184,246,90,120
257,1380,133,145,184,113,209,335,54,246,1990,37,275,44,120,1313,46,2222,448,23,90,84,1376,1689,301,527,1849
1.390559620323408,0.05173904046404934,2.0236236192967936,1.9573524101711695,1.6975470899868141,2.151887314605167,1.5805666593769274,1.1386619873046315,2.712662399939541,1.4249475180109552,-0.27588668305362396,2.8913413666749483,1.3088165399463132,2.8635099094119285,2.1158046507689834,0.10343536726148002,2.7926902914923...
3,282
Lysosome
26
48
3.948316
0.000079
P15586,Q14108,Q15904,Q9Y487,P04062,Q93050,Q8NCC3,O75503,Q9UMR5,P50897,Q9NZJ7,Q13510,P16278,P07858,P06280,P54802,P04066,P10619,P07686,P07602,O14773,Q99523,P38571,P11117,P06865,P17900
Processes and pathways
KEGG Pathways
msigdb_kegg
258,3,262,264,145,149,23,36,42,44,301,46,54,53,184,185,322,72,335,209,81,342,100,103,113,246
1653,1620,81,417,639,1983,36,145,322,184,113,209,335,53,854,2178,3196,372,72,103,978,478,723,1731,258,54,246,1257,100,44,813,185,1825,840,1604,1829,46,3,262,23,149,342,301,1690,2259,42,851,264
-0.1081959375724667,-0.09005424964602395,2.4255716705252155,0.9720538608178498,0.6252443929676549,-0.27588668305362396,2.898255890365687,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,1.5805666593769274,1.1386619873046315,2.712662399939541,0.4292836766633106,-0.37265087688372656,-1.682696739...
3,282
Organic acid transmembrane transport
22
33
3.759914
0.00017
Q9UJS0,P30825,P08195,O60831,P08183,Q9H2J7,P53985,Q9H2D1,Q9UBX3,P41440,Q9Y619,Q15041,P23786,Q8IWT6,Q8TDW0,P11166,P31751,O43772,O75915,Q96NB2,O14678,P28288
Processes and pathways
GO Biological process
msigdb_gobp
659,138,270,528,281,424,544,38,167,438,60,569,63,325,585,580,589,95,484,503,498,632
498,95,528,794,484,795,1601,281,270,580,63,632,138,589,1863,438,2924,1481,544,1003,569,650,325,585,503,38,424,1405,752,167,659,945,60
0.8101935073071703,2.3427776233754467,0.7684328524082645,0.47554353945259714,0.8377388499606527,0.47554353945259714,-0.07200734605445942,1.2731201713397275,1.3323904602126717,0.6976210318395957,2.6378827937194287,0.6398478494370026,1.9954018657539796,0.6832728352514132,-0.21908700961772024,0.9189967934039461,-0.9926104...
3,282
SLC superfamily of solute carriers
33
44
3.731123
0.000191
O43808,Q9UJS0,O95202,Q8TB61,P30825,Q70HW3,Q15758,P08195,Q6NUK1,O14975,Q8IXU6,Q9Y6M7,Q96H78,Q9H2J7,O95563,P53985,P55011,Q9H2D1,Q9UBX3,Q9NZJ7,O43826,P41440,Q9Y619,P11166,Q7L0J3,Q9Y6C9,Q6KCM7,O43772,Q9H9B4,Q96NB2,Q9H0U3,Q9HC21,P12236
Drugs and Diseases
Pharos Drug Target Ontology
pharos_dto
758,659,394,139,138,13,650,270,783,644,147,416,34,424,795,544,293,38,167,301,303,438,60,580,332,470,730,95,752,503,771,772,378
644,95,758,303,794,394,795,853,270,580,1255,378,138,438,1481,544,293,1550,1003,650,730,1395,783,2051,13,332,147,139,1012,34,503,771,38,424,1405,752,772,301,167,659,945,60,470,416
0.6105758605037124,2.3427776233754467,0.5060299163255124,1.2127112505391577,0.47554353945259714,1.0112796586421209,0.47554353945259714,0.4292836766633106,1.3323904602126717,0.6976210318395957,0.13746944516855703,1.0371659946513645,1.9954018657539796,0.9189967934039461,-0.0007502583674914466,0.740292053869216,1.23701393...
3,282
Sphingolipid metabolism
15
26
3.680296
0.000233
O15269,P27544,O95470,P10619,Q9NZJ7,Q13510,P04062,P07602,P06865,P16278,P17900,P06280,Q96G23,Q06136,P51648
Processes and pathways
Reactome Pathways
msigdb_reactome
257,37,133,72,301,46,145,209,113,54,246,184,90,120,157
775,257,1380,639,2239,133,145,184,113,209,335,72,1731,54,246,1990,37,157,120,46,448,90,1173,1376,301,1849
0.4908216973007541,1.390559620323408,0.05173904046404934,0.6252443929676549,-0.41211517468133246,2.0236236192967936,1.9573524101711695,1.6975470899868141,2.151887314605167,1.5805666593769274,1.1386619873046315,2.537625343517015,-0.144767223042154,2.712662399939541,1.4249475180109552,-0.27588668305362396,2.8913413666749...
3,282
Intrinsic component of mitochondrial inner membrane
23
32
3.678745
0.000234
Q99595,O60830,Q6UXV4,Q9H3K2,Q9Y2R0,Q13505,Q16891,Q9NVH1,Q9Y4W6,Q16134,Q5XKP0,Q9Y512,Q9NX63,Q15070,Q9UG56,Q9H9B4,Q5HYI7,O75880,Q8NE86,Q6P4A7,Q96NB2,Q9HC21,O14925
Localization
GO Cellular component
msigdb_gocc
4,10,651,402,24,25,412,805,687,440,570,458,348,216,483,752,97,477,488,230,503,772,253
253,1019,10,1571,477,795,2938,1550,25,216,440,412,2222,97,570,230,651,488,1589,503,4,2163,402,752,889,772,805,348,483,24,687,458
1.402064492860211,0.30269921647967324,3.4356976780399577,-0.05405435237037845,0.8514243186018405,0.47554353945259714,-1.0160076287643969,-0.03619440570372816,3.0526953443372964,1.5478733691269635,0.9189967934039461,0.9851824752695442,-0.3923277640646288,2.325930995779964,0.7119066464917171,1.4814285535206084,0.61057586...
3,282
Anion transmembrane transport
31
45
3.638519
0.000274
O43808,Q9UJS0,P30825,Q8TB61,Q15758,P08195,P21796,O60831,P08183,Q9Y6M7,O95563,P53985,P55011,Q9H2D1,Q9UBX3,Q9UHG3,P45880,O43826,P41440,Q15041,Q9Y619,Q8IWT6,Q8TDW0,P51798,P51790,Q9H9B4,O75915,Q96NB2,P12236,Q9HC21,Q9Y277
Processes and pathways
GO Biological process
msigdb_gobp
758,659,138,139,650,270,15,528,281,416,795,544,293,38,167,47,50,303,438,569,60,325,585,583,331,752,484,503,378,772,252
758,303,528,794,484,795,853,1601,281,270,1255,378,15,138,438,50,331,583,1481,544,293,1550,1003,1832,569,650,938,325,139,585,1012,503,38,1405,752,772,1567,167,47,659,252,945,1378,60,416
0.5060299163255124,1.2127112505391577,0.7684328524082645,0.47554353945259714,0.8377388499606527,0.47554353945259714,0.4292836766633106,-0.07200734605445942,1.2731201713397275,1.3323904602126717,0.13746944516855703,1.0371659946513645,3.223536276398023,1.9954018657539796,0.9189967934039461,2.7420278978751074,1.1511243328...
3,282
Organic anion transmembrane transporter activity
21
30
3.403911
0.000664
O43808,Q9UJS0,P30825,Q8TB61,Q15758,P08195,Q6NUK1,Q9Y6M7,O95563,P53985,Q9H2D1,Q9UBX3,P41440,Q9Y619,Q8IWT6,P11166,Q6KCM7,Q9H9B4,Q96NB2,Q9HC21,P12236
Functions
GO Molecular function
msigdb_gomf
758,659,138,139,650,270,783,416,795,544,38,167,438,60,325,580,730,752,503,772,378
2686,758,794,795,853,270,580,1255,378,138,438,1481,544,1003,650,730,783,2051,325,139,503,38,1405,752,772,167,659,945,60,416
-0.7446984489999219,0.5060299163255124,0.47554353945259714,0.47554353945259714,0.4292836766633106,1.3323904602126717,0.6976210318395957,0.13746944516855703,1.0371659946513645,1.9954018657539796,0.9189967934039461,-0.0007502583674914466,0.740292053869216,0.31878600721311506,0.6105758605037124,0.5362387937640063,0.490821...
3,282
Receptor
10
29
3.311084
0.000929
A6NIH7,Q9UQB8,Q14108,P57105,Q9BUN8,O75381,Q567V2,Q8WTV0,Q13641,O75787
Drugs and Diseases
Pharos Drug Target Ontology
pharos_dto
32,96,3,226,134,330,92,49,284,471
32,1330,1983,330,471,1986,1728,1601,478,1257,1423,1864,226,2704,284,3,1461,92,817,2251,49,1559,134,1614,1110,1722,2850,96,996
2.9461806183019617,0.0862900538235537,-0.27588668305362396,1.1511243328250194,0.8650522301865151,-0.27588668305362396,-0.144767223042154,-0.07200734605445942,0.8514243186018405,0.13746944516855703,0.03433177573533618,-0.21908700961772024,1.5037359284595075,-0.7446984489999219,1.2611307098563012,3.4972936020541496,0.016...
3,282
Protein insertion into membrane
10
30
3.307647
0.000941
Q9NS69,Q96A33,Q9P0J0,O14737,Q15629,Q9Y584,P46379,Q15070,Q9NPA0,Q8N4V1
Processes and pathways
GO Biological process
msigdb_gobp
0,299,107,143,51,57,122,216,256,223
143,2688,639,1383,924,2075,831,1544,2790,122,308,2380,1264,216,51,2222,729,1031,223,846,1145,299,256,0,107,1780,458,57,905,2025
1.9573524101711695,-0.7446984489999219,0.6252443929676549,0.05173904046404934,0.36658921531116717,-0.3142725349731669,0.4447751115533682,-0.03619440570372816,-0.8329007565972378,2.0975965576515088,1.2127112505391577,-0.4923924005392478,0.13746944516855703,1.5478733691269635,2.7273834505609806,-0.3923277640646288,0.5362...
3,282
Receptor
17
42
3.224626
0.001261
Q9NS69,Q9Y5M8,O00264,Q14108,Q14739,O15118,P30825,P35613,P24390,Q8WTV0,O15173,P02786,Q99523,Q99720,O43731,O75787,Q99623
Functions
Protein Atlas Molecular function
protein_atlas_molecular_function
0,225,224,3,69,417,138,312,45,49,114,240,342,26,27,471,288
224,892,417,114,27,471,3167,240,1601,661,1816,2935,1785,1658,978,478,2212,2375,1257,45,1757,138,312,1795,912,857,3,69,558,650,49,732,342,288,26,0,1110,1807,1222,870,225,2136
1.5148295730982289,0.3980834008801064,0.9720538608178498,2.1429079626659977,2.9999531979248477,0.8650522301865151,-1.544956106951877,1.4476634061842635,-0.07200734605445942,0.5958417361485769,-0.20035758061349548,-1.0160076287643969,-0.18172843641255768,-0.1081959375724667,0.3347961754544072,0.8514243186018405,-0.39232...
3,282
Mitochondrial protein import
14
37
3.216786
0.001296
Q9NS69,Q10713,O14925,Q99595,Q8N4H5,O60830,Q15388,P06576,Q9NX63,P21796,O95169,Q13505,O43615,Q9Y584
Processes and pathways
Reactome Pathways
msigdb_reactome
0,227,253,4,5,10,202,205,348,15,305,25,282,57
253,282,924,10,2992,1571,2719,794,2075,305,1000,205,1254,2891,1255,378,15,2179,2938,227,25,202,960,635,5,1747,4,3106,2868,0,348,659,1780,458,57,905,2025
1.402064492860211,1.2611307098563012,0.36658921531116717,3.4356976780399577,-1.087108280692871,-0.05405435237037845,-0.7665478813310426,0.47554353945259714,-0.3142725349731669,1.2127112505391577,0.31878600721311506,1.6021706965552707,0.13746944516855703,-0.9462602777918803,0.13746944516855703,1.0371659946513645,3.22353...
3,282
Rac2 gtpase cycle
10
33
3.189999
0.001423
Q9Y512,Q8TAA9,P50402,Q14739,Q86XL3,Q6IAA8,O15173,P02786,Q13505,Q7L576
Processes and pathways
Reactome Pathways
msigdb_reactome
458,101,261,69,142,399,114,240,25,319
114,2239,240,1601,2304,479,908,261,1632,1291,2309,980,2562,1262,25,1100,69,2115,1267,1217,1060,399,319,142,818,101,1144,1374,1173,1220,1039,1413,458
2.1429079626659977,-0.41211517468133246,1.4476634061842635,-0.07200734605445942,-0.45202600377615704,0.8514243186018405,0.3823733530740993,1.3790121380737033,-0.09005424964602395,0.12049491179844807,-0.45202600377615704,0.3347961754544072,-0.6373991838940739,0.13746944516855703,3.0526953443372964,0.25397254379079565,2....
3,282
Intrinsic component of endoplasmic reticulum membrane
41
57
3.120042
0.001808
O95470,Q9BUN8,Q9P035,Q15125,Q8TB61,O76024,Q86XL3,O14975,P57088,A0FGR8,Q8TCT8,Q9UM00,Q9Y4P3,Q9H490,Q9NQC3,Q96A33,Q9UBM7,Q6NTF9,Q8TCT9,P04439,Q15629,O43826,O43292,P49069,O00767,Q969N2,P51572,Q15041,Q8N766,Q86YN1,O75298,Q9Y282,P01889,O75844,Q5J8M3,P10321,Q92643,Q8N4V1,Q99442,Q96S52,Q9NPA0
Localization
GO Cellular component
msigdb_gocc
133,134,527,11,139,518,142,644,779,775,150,541,415,803,165,299,176,817,178,554,51,303,311,308,688,573,313,569,846,195,197,78,830,80,729,587,608,223,625,769,256
775,688,644,311,2688,303,197,80,518,133,830,554,587,2746,950,2303,308,313,779,2380,915,1523,1264,569,11,51,1964,729,817,861,142,195,223,846,139,150,178,608,573,299,769,625,1173,134,2323,803,1496,256,165,1689,527,2231,176,541,78,415,1350
0.4908216973007541,0.5661746186246456,0.6105758605037124,1.2004894005422622,-0.7446984489999219,1.2127112505391577,1.6236237566684577,2.4499538883891847,0.7824126866297165,2.0236236192967936,0.4447751115533682,0.7261301615080007,0.6832728352514132,-0.7885304430072586,0.35073036585612155,-0.45202600377615704,1.212711250...
3,282
Hexosyltransferase activity
19
31
3.114008
0.001846
Q10472,P04062,Q10471,O43505,Q6ZXV5,O60762,Q13126,P07686,P11216,Q8N4A0,Q2TAA5,Q8TCJ2,P04843,P06865,P46977,P04844,Q9BV10,Q9BT22,Q9NYU2
Functions
GO Molecular function
msigdb_gomf
390,145,782,168,572,578,76,335,722,94,858,638,485,113,373,873,248,515,642
1810,2430,168,578,1284,145,485,873,1071,113,335,722,1508,2461,373,1580,782,390,76,858,1586,572,2153,94,638,515,248,2478,920,642,1114
-0.20035758061349548,-0.5332236662674483,1.8001335532224074,0.6976210318395957,0.12049491179844807,1.9573524101711695,0.8377388499606527,0.41371997306172403,0.2702931493830407,2.151887314605167,1.1386619873046315,0.5362387937640063,-0.018426654504152068,-0.553816606593548,1.0500310352209634,-0.05405435237037845,0.49082...
3,282
Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen
12
33
3.097819
0.00195
P09601,P30519,O95864,Q32P28,P16435,P13674,Q9NVH6,Q6UW02,Q14534,Q15800,O75845,Q16850
Functions
GO Molecular function
msigdb_gomf
87,1,508,421,265,395,427,173,210,89,405,183
1810,688,1183,1185,975,2298,405,508,1941,87,395,265,1,1511,2081,1580,1390,210,89,183,421,1268,173,1608,2154,2283,549,802,3037,1326,427,2485,1650
-0.20035758061349548,0.5661746186246456,0.18789041292229028,0.18789041292229028,0.3347961754544072,-0.45202600377615704,0.9982576128879851,0.7963327544291974,-0.25685057969960273,2.3927379782175318,1.0112796586421209,1.367421765529877,3.6996155662973718,-0.018426654504152068,-0.3142725349731669,-0.05405435237037845,0.0...
3,282
Sterol metabolic process
18
42
3.085517
0.002032
Q14739,Q9BQE5,Q15392,P48449,P16435,P05067,Q15125,P49748,P38571,Q9UBM7,P04062,Q8WTV0,Q14534,Q15800,O75845,Q16850,Q14849,P37268
Processes and pathways
GO Biological process
msigdb_gobp
69,6,135,418,265,169,11,396,100,176,145,49,210,89,405,183,250,31
417,2720,405,1783,2763,3167,145,169,1659,833,265,2956,620,31,100,2959,418,396,1954,3052,840,1913,2111,2146,1313,2942,210,69,250,1525,11,2860,135,1917,89,183,1124,49,6,176,1112,1980
0.9720538608178498,-0.7665478813310426,0.9982576128879851,-0.18172843641255768,-0.8106475789227858,-1.544956106951877,1.9573524101711695,1.8001335532224074,-0.1081959375724667,0.4447751115533682,1.367421765529877,-1.0395551932285616,0.6543867400016848,2.9529597638291984,2.3089861165903924,-1.0395551932285616,0.97205386...
3,282
Ceramide metabolic process
12
18
3.042441
0.002347
O15269,P27544,O95470,Q13510,P04062,P06865,P30153,Q99805,P17900,Q8NCC3,P06280,Q96G23
Processes and pathways
GO Biological process
msigdb_gobp
257,37,133,46,145,113,275,84,246,23,184,90
257,1380,133,145,184,113,335,246,37,275,1313,46,2222,448,23,90,84,1376
1.390559620323408,0.05173904046404934,2.0236236192967936,1.9573524101711695,1.6975470899868141,2.151887314605167,1.1386619873046315,1.4249475180109552,2.8913413666749483,1.3088165399463132,0.10343536726148002,2.792690291492383,-0.3923277640646288,0.9055948775740706,3.1108414574807464,2.3844709040308296,2.42557167052521...
3,282
Vacuolar lumen
29
64
3.031356
0.002435
P15586,Q14108,Q9H7Z7,P04062,Q9BTY2,Q9UMR5,Q8NHP8,P50897,Q9NZJ7,Q13510,P16278,P38435,P07858,P06280,P54802,Q8IV08,P04066,P10619,P07686,P07602,O14773,O00584,P38571,P11117,P06865,O00560,P10253,P17900,Q99536
Localization
GO Cellular component
msigdb_gocc
258,3,131,145,151,42,40,44,301,46,54,55,53,184,185,59,322,72,335,209,81,212,100,103,113,371,372,246,251
371,212,81,639,2763,145,322,184,113,926,2176,209,335,53,831,854,372,72,103,1942,722,723,1731,258,54,246,2856,2267,2788,55,100,2409,44,2216,1954,813,910,185,2895,2515,840,1519,2985,462,46,3,1667,59,1774,3095,40,413,1588,2011,251,599,151,992,1015,131,2018,301,42,2973
1.0500310352209634,1.5588097511325756,2.4255716705252155,0.6252443929676549,-0.8106475789227858,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,0.36658921531116717,-0.37265087688372656,1.5805666593769274,1.1386619873046315,2.712662399939541,0.4447751115533682,0.4292836766633106,1.050031035220...
3,282
Molecular transducer activity
18
36
3.0248
0.002488
P11717,Q14108,Q9BUN8,O15118,Q99442,Q15375,Q00688,Q15758,P30536,Q6RW13,Q8WTV0,O15173,Q15629,Q9UGP8,Q99523,Q99720,O75787,Q08722
Functions
GO Molecular function
msigdb_gomf
478,3,134,417,625,558,519,650,380,400,49,114,51,705,342,26,471,568
892,417,114,2661,471,1601,1658,478,1257,1757,380,2609,1864,1950,519,912,568,857,3,558,51,650,1640,400,49,732,625,342,26,134,2972,1110,2231,1807,705,1809
0.3980834008801064,0.9720538608178498,2.1429079626659977,-0.7229807232924671,0.8650522301865151,-0.07200734605445942,-0.1081959375724667,0.8514243186018405,0.13746944516855703,-0.1631986289661192,1.0371659946513645,-0.6799348090885988,-0.21908700961772024,-0.25685057969960273,0.7824126866297165,0.3823733530740993,0.711...
3,282
Anion transmembrane transporter activity
32
46
3.011287
0.002601
O43681,Q9NW15,O43808,Q9UJS0,P30825,Q8TB61,Q15758,P08195,P21796,Q6NUK1,Q9Y6M7,O95563,P53985,P55011,Q9C0H2,Q9UBX3,Q9H2D1,P45880,O43826,P41440,Q9Y619,Q8IWT6,Q8TDW0,P51798,P11166,P51790,Q6KCM7,Q9H9B4,Q96NB2,P12236,Q9HC21,Q9Y277
Functions
GO Molecular function
msigdb_gomf
639,391,758,659,138,139,650,270,15,783,416,795,544,293,41,167,38,50,303,438,60,325,585,583,580,331,730,752,503,378,772,252
3163,2686,639,758,303,794,795,853,270,580,1255,378,15,138,438,50,331,583,1481,544,293,1003,650,938,730,1395,783,2051,325,139,585,1012,503,41,38,1405,752,772,391,167,659,252,945,60,3220,416
-1.5179982112659076,-0.7446984489999219,0.6252443929676549,0.5060299163255124,1.2127112505391577,0.47554353945259714,0.47554353945259714,0.4292836766633106,1.3323904602126717,0.6976210318395957,0.13746944516855703,1.0371659946513645,3.223536276398023,1.9954018657539796,0.9189967934039461,2.7420278978751074,1.1511243328...
3,282
Intrinsic component of mitochondrial membrane
32
50
3.000547
0.002695
Q99595,O60830,Q6UXV4,Q9H3K2,Q9Y2R0,Q13505,Q16891,Q9NVH1,Q8TB36,Q9Y4W6,Q16134,Q5XKP0,Q9Y512,Q15388,Q8IWA4,Q969V5,Q9NX63,Q15070,Q9UG56,Q9H9B4,Q9BPX6,O75880,Q8NE86,P57105,Q6P4A7,Q5HYI7,Q9BWH2,Q96NB2,Q9BUB7,Q9HC21,Q9GZY8,O14925
Localization
GO Cellular component
msigdb_gocc
4,10,651,402,24,25,412,805,679,687,440,570,458,202,596,218,348,216,483,752,354,477,488,226,230,97,626,503,770,772,381,253
253,1019,10,1571,477,2075,1418,795,1000,1255,2938,2924,226,1550,25,216,202,440,412,2222,97,570,230,651,596,2520,2090,488,679,218,1589,503,4,354,770,2163,626,381,402,752,889,772,2482,805,348,483,1039,24,687,458
1.402064492860211,0.30269921647967324,3.4356976780399577,-0.05405435237037845,0.8514243186018405,-0.3142725349731669,0.03433177573533618,0.47554353945259714,0.31878600721311506,0.13746944516855703,-1.0160076287643969,-0.9926104125098789,1.5037359284595075,-0.03619440570372816,3.0526953443372964,1.5478733691269635,1.612...
3,282
Mitochondrial transmembrane transport
18
49
2.999895
0.002701
P23786,Q9BPX6,O14925,Q99595,Q9H2D1,Q6P4A7,P56385,O60830,P24539,Q15388,P06576,O95831,P21796,O75964,P12236,O43615,Q9Y619,O43772
Processes and pathways
GO Biological process
msigdb_gobp
63,354,253,4,38,230,215,10,170,202,205,237,15,17,378,282,60,95
253,282,95,10,542,2719,794,2266,17,2075,394,795,237,1000,853,205,2891,1255,378,15,63,170,2179,672,1576,2924,1481,1359,215,1550,202,960,230,1747,488,2730,1145,1589,503,4,354,38,1405,752,2868,659,868,687,60
1.402064492860211,1.2611307098563012,2.3427776233754467,3.4356976780399577,0.740292053869216,-0.7665478813310426,0.47554353945259714,-0.4320142141361126,3.186489069229093,-0.3142725349731669,1.0112796586421209,0.47554353945259714,1.4589593479977,0.31878600721311506,0.4292836766633106,1.6021706965552707,-0.9462602777918...
3,282
Abnormal circulating cholesterol concentration
16
38
2.973953
0.00294
Q9BV10,P50402,Q15904,Q15392,Q14739,P38571,Q9NVI7,Q15125,Q9NZJ7,Q9UBM7,P07602,O43826,Q15800,Q13045,Q8N511,P37268
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
248,261,262,135,69,100,360,11,301,176,209,303,89,314,29,31
3058,303,1571,405,3167,977,1071,209,31,100,1993,2923,261,3041,567,840,1869,782,314,1635,69,11,135,1917,89,262,1124,2881,29,700,609,248,2292,360,301,176,659,601
-1.2087461517878753,1.2127112505391577,-0.05405435237037845,0.9982576128879851,-1.544956106951877,0.3347961754544072,0.2702931493830407,1.5805666593769274,2.9529597638291984,2.3089861165903924,-0.27588668305362396,-0.9926104125098789,1.3790121380737033,-1.159609495028328,0.7119066464917171,0.4447751115533682,-0.2190870...
3,282
Alpha/Beta hydrolase fold [IPR029058]
13
27
2.971991
0.002959
Q8NCG7,P38571,Q9UMR5,P10619,Q9HB40,P50897,Q9NUJ1,Q4J6C6,Q9H3G5,P42785,Q8NCC3,P07099,Q9H6V9
Sequence
InterPro Superfamily
interpro_homologous_superfamily
228,100,42,72,12,44,310,338,19,20,23,124,30
3182,124,72,3156,1944,100,20,1910,1950,44,338,1463,2007,1202,368,23,228,3145,2546,3083,19,30,12,310,2579,42,2991
-1.5994545700709446,2.0884502877831217,2.537625343517015,-1.491231286058741,-0.25685057969960273,2.3089861165903924,3.142617455562031,-0.23791768452069523,-0.25685057969960273,2.8635099094119285,1.1261505340235223,0.01683561215363658,-0.27588668305362396,0.18789041292229028,1.0628444846588703,3.1108414574807464,1.50373...
3,282
Golgi cisterna
17
27
2.959936
0.003077
Q10713,Q10472,Q16706,Q8WVQ1,Q8NBZ7,Q9Y6B6,O95249,P04439,Q8TBA6,P98194,O00461,Q12893,Q99523,Q8NBN3,P51572,Q9H4A6,Q9BXS4
Localization
GO Cellular component
msigdb_gocc
227,390,451,199,452,601,144,554,339,407,85,530,342,118,313,516,221
85,1148,144,554,313,407,743,640,782,390,227,530,2277,899,451,118,452,339,1272,199,2355,342,221,2650,516,1327,601
2.4173982018988323,0.2045322897893938,1.9573524101711695,0.7261301615080007,1.2004894005422622,0.9982576128879851,0.5211687621279207,0.6252443929676549,0.4908216973007541,1.0242489935338948,1.5037359284595075,0.7684328524082645,-0.4320142141361126,0.3980834008801064,0.8921370887005844,2.124866780378862,0.89213708870058...
3,282
Golgi stack
23
34
2.953736
0.00314
Q10472,Q08379,O95249,P98194,Q12893,Q10471,P04439,P51572,Q16706,Q8WVQ1,Q8NBZ7,Q9Y6B6,Q8TBA6,O00461,Q99523,Q9BXS4,Q10713,Q14789,Q08378,Q9H4A6,Q8NBN3,Q15363,Q9Y296
Localization
GO Cellular component
msigdb_gocc
390,640,144,407,530,782,554,313,451,199,452,601,339,85,342,221,227,882,743,516,118,899,903
85,1148,906,144,554,2108,313,1738,407,1869,743,640,782,390,227,530,882,2277,899,451,118,452,339,1272,199,2355,342,2901,221,2650,516,1327,903,601
2.4173982018988323,0.2045322897893938,0.3823733530740993,1.9573524101711695,0.7261301615080007,-0.33362432918571483,1.2004894005422622,-0.144767223042154,0.9982576128879851,-0.21908700961772024,0.5211687621279207,0.6252443929676549,0.4908216973007541,1.0242489935338948,1.5037359284595075,0.7684328524082645,0.4137199730...
3,282
Hydrolase activity acting on glycosyl bonds
15
28
2.944166
0.003238
O60502,Q9UKM7,O75503,P04066,P07686,P04062,Q9NUJ1,P06865,P10253,P16278,Q9BTY2,P17900,P06280,P54802,Q13724
Functions
GO Molecular function
msigdb_gomf
129,350,36,322,335,145,310,113,372,54,151,246,184,185,155
1855,129,36,145,322,184,113,335,854,372,3114,2693,54,246,1455,3240,1386,2461,185,1957,155,1361,451,2986,151,310,2448,350
-0.21908700961772024,2.060840721286124,2.898255890365687,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,1.1386619873046315,0.4292836766633106,1.0500310352209634,-1.334509459001553,-0.7446984489999219,2.712662399939541,1.4249475180109552,0.01683561215363658,-2.15992240998839,0.051739040464049...
3,282
Membrane lipid biosynthetic process
14
23
2.943058
0.00325
Q6ZMG9,O15269,O95470,Q9P035,P27544,Q96G23,O60762,Q13510,P04062,Q99805,O43292,Q06136,Q969N2,Q8NBX0
Processes and pathways
GO Biological process
msigdb_gobp
448,257,133,527,37,90,578,46,145,84,311,120,573,28
257,1380,311,578,133,145,1990,37,120,1313,46,2222,448,28,608,573,90,769,84,803,1376,527,1849
1.390559620323408,0.05173904046404934,1.2004894005422622,0.6976210318395957,2.0236236192967936,1.9573524101711695,-0.27588668305362396,2.8913413666749483,2.1158046507689834,0.10343536726148002,2.792690291492383,-0.3923277640646288,0.9055948775740706,2.9999531979248477,0.6688615690298855,0.7119066464917171,2.38447090403...
3,282
Carboxylic acid transport
21
38
2.912393
0.003587
Q9UJS0,P30825,P08195,O60831,Q9H2J7,P53985,P55011,Q9H2D1,Q9UBX3,Q9NZJ7,P41440,Q9Y619,Q15041,Q8IWT6,Q8TDW0,Q7L0J3,P07602,O75915,Q96NB2,P28288,P04083
Processes and pathways
GO Biological process
msigdb_gobp
659,138,270,528,424,544,293,38,167,301,438,60,569,325,585,332,209,484,503,632,377
2686,3005,528,794,484,795,377,1601,209,270,3089,1735,632,138,438,1481,544,293,2962,1003,1313,569,1460,650,2051,332,325,585,503,38,424,1405,752,301,167,659,945,60
-0.7446984489999219,-1.1111173323671646,0.7684328524082645,0.47554353945259714,0.8377388499606527,0.47554353945259714,1.0371659946513645,-0.07200734605445942,1.5805666593769274,1.3323904602126717,-1.2585426463884428,-0.144767223042154,0.6398478494370026,1.9954018657539796,0.9189967934039461,-0.0007502583674914466,0.740...
3,282
Passive transmembrane transporter activity
16
34
2.865769
0.00416
Q9NW15,Q8IWT6,Q8TDW0,Q8NE86,Q9C0H2,P24539,P51790,P06576,P21796,Q9BVC6,O75964,P45880,Q9Y277,P56385,Q99797,Q9UM00
Functions
GO Molecular function
msigdb_gomf
391,325,585,488,41,170,331,205,15,467,17,50,252,215,540,541
3163,2266,17,1000,205,926,2105,15,170,2179,672,1789,1423,50,1576,331,583,1359,215,2380,2877,938,325,488,585,732,1589,540,467,41,391,541,252,3220
-1.5179982112659076,-0.4320142141361126,3.186489069229093,0.31878600721311506,1.6021706965552707,0.36658921531116717,-0.33362432918571483,3.223536276398023,1.7798918673967443,-0.37265087688372656,0.5810414981125253,-0.18172843641255768,0.03433177573533618,2.7420278978751074,-0.05405435237037845,1.1511243328250194,0.697...
3,282
Lytic vacuole organization
12
22
2.842107
0.004482
Q14108,O75503,P11117,P50897,Q6IAA8,P07686,P04062,O14773,P10253,P54802,O75787,Q8N511
Processes and pathways
GO Biological process
msigdb_gobp
3,36,103,44,399,335,145,81,372,185,471,29
1653,81,36,471,1331,145,335,372,103,673,44,1632,185,1738,546,3,399,29,1032,788,2650,1534
-0.1081959375724667,2.4255716705252155,2.898255890365687,0.8650522301865151,0.0862900538235537,1.9573524101711695,1.1386619873046315,1.0500310352209634,2.283382339582687,0.5810414981125253,2.8635099094119285,-0.09005424964602395,1.6975470899868141,-0.144767223042154,0.740292053869216,3.4972936020541496,1.01127965864212...
3,282
Abnormality of head blood vessel
11
28
2.841229
0.004494
P48651,P10619,P03886,Q9NZJ7,Q13510,P07686,P07602,P06865,P16278,P17900,P21964
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
323,72,75,301,46,335,209,113,54,246,379
1982,1782,1250,1282,3167,75,721,113,209,335,72,2607,54,246,1735,379,2034,323,2669,1739,46,883,1124,2521,2420,301,1897,415
-0.27588668305362396,-0.18172843641255768,0.13746944516855703,0.12049491179844807,-1.544956106951877,2.506054203043081,0.5362387937640063,2.151887314605167,1.5805666593769274,1.1386619873046315,2.537625343517015,-0.6799348090885988,2.712662399939541,1.4249475180109552,-0.144767223042154,1.0371659946513645,-0.2950269962...
3,282
Organic anion transport
33
50
2.830562
0.004647
O43808,Q9UJS0,P30825,Q8TB61,Q15758,P08195,Q6NUK1,O60831,Q9Y6M7,Q9H2J7,O95563,P53985,P55011,Q9H2D1,Q9UBX3,Q9NZJ7,P41440,Q9Y619,Q15041,Q08722,Q8IWT6,Q8TDW0,P11166,Q7L0J3,P07602,Q6KCM7,Q9H9B4,Q9HC21,O75915,Q96NB2,P28288,P12236,P04083
Processes and pathways
GO Biological process
msigdb_gobp
758,659,138,139,650,270,783,528,416,424,795,544,293,38,167,301,438,60,569,568,325,585,580,332,209,730,752,772,484,503,632,378,377
2686,3005,758,528,794,484,795,377,853,1601,209,270,580,1255,378,3089,1735,632,138,438,1481,544,293,2962,1003,568,1313,569,1460,650,730,783,2051,332,325,139,585,503,38,424,1405,752,772,301,167,1980,659,945,60,416
-0.7446984489999219,-1.1111173323671646,0.5060299163255124,0.7684328524082645,0.47554353945259714,0.8377388499606527,0.47554353945259714,1.0371659946513645,0.4292836766633106,-0.07200734605445942,1.5805666593769274,1.3323904602126717,0.6976210318395957,0.13746944516855703,1.0371659946513645,-1.2585426463884428,-0.14476...
3,282
Sphingolipid metabolism
6
9
2.804038
0.005047
O95470,Q13510,P04062,P07602,P17900,Q06136
Processes and pathways
Protein Atlas Biological process
protein_atlas_biological_process
133,46,145,209,246,120
257,1380,133,145,209,246,120,46,1689
1.390559620323408,0.05173904046404934,2.0236236192967936,1.9573524101711695,1.5805666593769274,1.4249475180109552,2.1158046507689834,2.792690291492383,-0.1081959375724667
3,282
Retrograde vesicle mediated transport golgi to endoplasmic reticulum
11
29
2.802555
0.00507
P49755,P61923,P24390,O15258,Q9Y282,Q12893,Q8TD16,Q96RQ1,O43731,Q9H4A6,Q9P2W9
Processes and pathways
GO Biological process
msigdb_gobp
386,397,45,517,78,530,501,219,27,516,62
1934,1902,517,27,1623,2937,45,1422,1993,1791,1333,386,2305,397,1139,2672,530,593,915,501,1272,1561,2355,1613,219,516,62,1929,78
-0.25685057969960273,-0.23791768452069523,0.7824126866297165,2.9999531979248477,-0.09005424964602395,-1.0160076287643969,2.821234068592441,0.03433177573533618,-0.27588668305362396,-0.18172843641255768,0.0862900538235537,1.0242489935338948,-0.45202600377615704,1.0112796586421209,0.22109280361990064,-0.7229807232924671,0...
3,282
Protein transmembrane transport
12
28
2.788436
0.005296
Q9NS69,Q99595,O75298,P49755,O60830,O75381,Q15388,O95831,Q15629,Q9Y584,O43615,O14925
Processes and pathways
GO Biological process
msigdb_gobp
0,4,197,386,10,330,202,237,51,57,282,253
253,282,1856,10,197,330,2075,237,1000,2891,589,386,694,3250,2464,1701,2380,398,202,51,960,1747,625,4,2868,0,705,57
1.402064492860211,1.2611307098563012,-0.21908700961772024,3.4356976780399577,1.6236237566684577,1.1511243328250194,-0.3142725349731669,1.4589593479977,0.31878600721311506,-0.9462602777918803,0.6832728352514132,1.0242489935338948,0.5661746186246456,-2.321881693407483,-0.553816606593548,-0.12643329600044367,-0.4923924005...
3,282
Glycosidase
12
18
2.787356
0.005314
O60502,P04066,P07686,P04062,P06865,P10253,P16278,Q9BTY2,Q9UKM7,P54802,Q13724,P06280
Functions
Protein Atlas Molecular function
protein_atlas_molecular_function
129,322,335,145,113,372,54,151,350,185,155,184
1855,129,145,322,184,113,335,854,372,54,2461,185,1957,155,1361,451,151,350
-0.21908700961772024,2.060840721286124,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,1.1386619873046315,0.4292836766633106,1.0500310352209634,2.712662399939541,-0.553816606593548,1.6975470899868141,-0.25685057969960273,1.9090993860580008,0.06905820401443656,0.8921370887005844,1.928493985010...
3,282
Membrane lipid catabolic process
8
10
2.779192
0.005449
P04066,O95470,P50897,Q13510,P04062,P06865,P17900,P06280
Processes and pathways
GO Biological process
msigdb_gobp
322,133,44,46,145,113,246,184
133,145,322,184,113,335,246,44,46,1376
2.0236236192967936,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,1.1386619873046315,1.4249475180109552,2.8635099094119285,2.792690291492383,0.06905820401443656
3,282
Hydrolase activity hydrolyzing o glycosyl compounds
14
20
2.776485
0.005495
O60502,Q9UKM7,P04066,P07686,P04062,Q9NUJ1,P06865,P10253,P16278,Q9BTY2,P17900,P06280,P54802,Q13724
Functions
GO Molecular function
msigdb_gomf
129,350,322,335,145,310,113,372,54,151,246,184,185,155
129,145,322,184,113,335,854,372,54,246,2461,185,155,1361,451,2986,151,310,2448,350
2.060840721286124,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,1.1386619873046315,0.4292836766633106,1.0500310352209634,2.712662399939541,1.4249475180109552,-0.553816606593548,1.6975470899868141,1.9090993860580008,0.06905820401443656,0.8921370887005844,-1.0632548272686395,1.928493985010192...
3,282
Rhog gtpase cycle
12
36
2.763617
0.005716
P42167,Q8TAA9,P50402,Q14739,O95202,Q13190,Q86XL3,Q6IAA8,Q96JJ3,O15173,P02786,Q7L576
Processes and pathways
Reactome Pathways
msigdb_reactome
479,101,261,69,394,521,142,399,401,114,240,319
114,737,2174,394,2239,240,1601,1094,2304,479,261,1632,1291,2309,557,1958,1552,2562,1262,521,1100,69,2343,1267,1217,399,319,861,142,818,101,1144,401,1374,1173,1220
2.1429079626659977,0.5211687621279207,-0.37265087688372656,1.0112796586421209,-0.41211517468133246,1.4476634061842635,-0.07200734605445942,0.25397254379079565,-0.45202600377615704,0.8514243186018405,1.3790121380737033,-0.09005424964602395,0.12049491179844807,-0.45202600377615704,0.7261301615080007,-0.25685057969960273,...
3,282
Proton transmembrane transporter activity
11
35
2.758057
0.005815
Q9UDW1,Q9Y487,P00403,P24539,P51790,P56385,P06576,Q13423,O75964,Q93050,P13073
Functions
GO Molecular function
msigdb_gomf
68,264,292,170,331,215,205,238,17,149,153
793,2266,17,394,292,853,205,1254,2211,1255,153,2919,663,778,3176,170,2179,2920,672,693,1789,1866,1576,331,1359,215,1825,1550,238,1012,149,1405,68,1690,264
0.47554353945259714,-0.4320142141361126,3.186489069229093,1.0112796586421209,1.2370139309648251,0.4292836766633106,1.6021706965552707,0.13746944516855703,-0.3923277640646288,0.13746944516855703,1.918812369361769,-0.9926104125098789,0.5958417361485769,0.4908216973007541,-1.5721074020422647,1.7798918673967443,-0.37265087...
3,282
Ion transport
31
52
2.754276
0.005882
P16615,Q15904,Q9Y487,O95202,P21796,O75964,Q93050,P98194,Q9UM00,Q9Y6M7,Q9H2J7,P55011,Q9C0H2,P24539,P36542,P45880,P36543,P23634,Q8IWT6,Q8TDW0,P51798,P51790,P06576,Q9BVC6,P56385,Q8NE01,Q9BPX6,Q8NE86,Q6P4Q7,P20020,Q9Y277
Processes and pathways
Protein Atlas Biological process
protein_atlas_biological_process
384,262,264,394,15,17,149,407,541,416,424,293,41,170,672,50,693,565,325,585,583,331,205,467,215,482,354,488,242,618,252
3163,2266,17,394,1000,810,1117,205,384,618,778,3176,15,565,170,2179,672,693,1789,50,1576,331,583,1053,293,1359,215,1825,407,728,262,938,1395,242,325,482,488,585,1012,149,1589,354,467,41,424,1690,541,252,945,264,3220,416
-1.5179982112659076,-0.4320142141361126,3.186489069229093,1.0112796586421209,0.31878600721311506,0.46019487053471625,0.23757265698845073,1.6021706965552707,1.0242489935338948,0.6543867400016848,0.4908216973007541,-1.5721074020422647,3.223536276398023,0.7119066464917171,1.7798918673967443,-0.37265087688372656,0.58104149...
3,282
Tetrapyrrole binding
8
16
2.748561
0.005986
P09601,Q8WUJ1,P30519,Q9H7Z7,Q6UW02,O15173,O43169,Q16850
Functions
GO Molecular function
msigdb_gomf
87,161,1,131,173,114,119,183
224,2582,114,119,1254,87,1153,1,877,183,173,161,2354,641,131,1498
1.5148295730982289,-0.6586038820934165,2.1429079626659977,2.1158046507689834,0.13746944516855703,2.3927379782175318,0.2045322897893938,3.6996155662973718,0.41371997306172403,1.7183433107459631,1.7798918673967443,1.8699301411864542,-0.4721516811947069,0.6252443929676549,2.042290468438935,-0.0007502583674914466
3,282
Lipid droplet
8
30
2.748168
0.005993
O43760,P48449,Q9H4M9,Q07065,Q99720,P51572,Q8NBX0,Q9H6V9
Localization
GO Cellular component
msigdb_gocc
162,418,426,121,26,313,28,30
1936,162,1695,1621,1507,2763,2953,926,418,1096,1632,313,2895,2308,121,1460,1917,1708,511,1062,28,1398,1561,1588,26,426,30,1497,2606,1350
-0.25685057969960273,1.850152544618409,-0.12643329600044367,-0.09005424964602395,-0.018426654504152068,-0.8106475789227858,-1.0395551932285616,0.36658921531116717,0.9720538608178498,0.25397254379079565,-0.09005424964602395,1.2004894005422622,-0.9462602777918803,-0.45202600377615704,2.106714627386444,0.01683561215363658...
3,282
Hyperlipidemia
16
32
2.737746
0.006186
P23786,Q9Y285,O43707,P50402,Q9UJS0,O95470,P38571,O75844,Q92734,P28070,O43826,P31751,Q13045,Q969N2,P06280,Q9BTV4
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
63,686,602,261,659,133,100,80,534,115,303,589,314,573,184,609
1782,602,303,1571,80,133,3167,977,184,1071,1093,63,115,1542,589,2461,100,261,2924,2335,314,1635,1124,1671,2881,700,534,573,2572,609,659,686
-0.18172843641255768,0.6688615690298855,1.2127112505391577,-0.05405435237037845,2.4499538883891847,2.0236236192967936,-1.544956106951877,0.3347961754544072,1.6975470899868141,0.2702931493830407,0.25397254379079565,2.6378827937194287,2.1339011676066857,-0.03619440570372816,0.6832728352514132,-0.553816606593548,2.3089861...
3,282
Abnormal enchondral ossification
13
29
2.727336
0.006385
Q14739,Q96HY6,Q8WVQ1,O95202,Q15125,O75381,Q9UBM7,Q7RTS9,P38435,Q9Y619,O96028,Q9UG56,P40855
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
69,263,199,394,11,330,176,239,55,60,376,483,351
493,1856,2853,330,394,376,854,690,3133,893,55,351,694,1517,1701,3203,69,2637,11,1917,1394,239,1712,199,263,176,483,2486,60
0.8239953918824245,-0.21908700961772024,-0.900491564579252,1.1511243328250194,1.0112796586421209,1.0371659946513645,0.4292836766633106,0.5661746186246456,-1.3860262152164,0.3980834008801064,2.712662399939541,1.1009789242465366,0.5661746186246456,-0.018426654504152068,-0.12643329600044367,-1.7108530645839468,2.576604864...
3,282
Glycosphingolipid metabolism
9
15
2.720462
0.006519
P10619,Q9NZJ7,Q13510,P04062,P07602,P06865,P16278,P17900,P06280
Processes and pathways
Reactome Pathways
msigdb_reactome
72,301,46,145,209,113,54,246,184
775,639,145,184,113,209,335,72,1731,54,246,46,1173,1376,301
0.4908216973007541,0.6252443929676549,1.9573524101711695,1.6975470899868141,2.151887314605167,1.5805666593769274,1.1386619873046315,2.537625343517015,-0.144767223042154,2.712662399939541,1.4249475180109552,2.792690291492383,0.2045322897893938,0.06905820401443656,1.2248859870045634
3,282
Apical plasma membrane
28
46
2.713356
0.006661
P30825,P08195,P21281,P35241,P08183,Q99797,Q9Y6M7,P53985,P55011,Q14254,P41440,P07858,P05023,P36543,P26038,P23634,O75955,P11166,P51790,P08238,Q16625,P19022,P15311,O75787,Q86UE4,P20020,P36551,P04083
Localization
GO Cellular component
msigdb_gocc
138,270,778,529,281,540,416,544,293,677,438,53,810,693,692,565,689,580,331,832,336,834,588,471,222,618,247,377
2262,2686,852,471,689,377,810,1117,53,281,270,1626,832,580,2405,588,834,618,778,565,692,138,529,693,247,1789,438,331,544,1053,293,1825,1313,2941,677,959,336,222,1492,540,1497,1146,1688,945,1618,416
-0.4320142141361126,-0.7446984489999219,0.4292836766633106,0.8650522301865151,0.5661746186246456,1.0371659946513645,0.46019487053471625,0.23757265698845073,2.712662399939541,1.2731201713397275,1.3323904602126717,-0.09005424964602395,0.4447751115533682,0.6976210318395957,-0.5127493328269307,0.6832728352514132,0.44477511...
3,282
Glycoside hydrolase superfamily [IPR017853]
10
15
2.694742
0.007044
O60502,P04066,P08195,P07686,P04062,P06865,P16278,Q9BTY2,P06280,P54802
Sequence
InterPro Superfamily
interpro_homologous_superfamily
129,322,270,335,145,113,54,151,184,185
129,145,322,184,113,335,270,854,372,54,2461,185,1361,151,992
2.060840721286124,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,1.1386619873046315,1.3323904602126717,0.4292836766633106,1.0500310352209634,2.712662399939541,-0.553816606593548,1.6975470899868141,0.06905820401443656,1.9284939850101928,0.3347961754544072
3,282
Sphingolipid metabolism
6
11
2.691187
0.00712
O95470,Q13510,P04062,P16278,P06280,Q06136
Processes and pathways
KEGG Pathways
msigdb_kegg
133,46,145,54,184,120
257,1380,639,133,145,184,1731,54,120,46,1376
1.390559620323408,0.05173904046404934,0.6252443929676549,2.0236236192967936,1.9573524101711695,1.6975470899868141,-0.144767223042154,2.712662399939541,2.1158046507689834,2.792690291492383,0.06905820401443656
3,282
Glycerophospholipid biosynthesis
11
33
2.679229
0.007379
P48651,Q9UG56,Q9NQZ5,P35790,Q9NPH0,Q9BVG9,Q8NCC3,Q96N66,Q8IV08,Q9NUQ2,Q8N2A8
Processes and pathways
Reactome Pathways
msigdb_reactome
323,483,136,105,112,374,23,315,59,347,191
776,809,2140,646,2814,1946,105,2078,1737,323,1333,3172,1548,1226,2222,500,885,59,191,23,1398,1203,701,315,2423,1402,374,969,823,112,136,347,483
0.4908216973007541,0.46019487053471625,-0.3530834233869732,0.6105758605037124,-0.8552914666396761,-0.25685057969960273,2.2747975061979706,-0.3142725349731669,-0.144767223042154,1.1759030599472666,0.0862900538235537,-1.544956106951877,-0.03619440570372816,0.15435971553016048,-0.3923277640646288,0.8101935073071703,0.4137...
3,282
Ventricular arrhythmia
14
39
2.678566
0.007394
P23786,P50402,P42892,P00403,P49748,O75306,P03886,Q9BTV4,Q8WXH0,P10253,P36551,P13473,P03915,O43772
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
63,261,71,292,396,267,75,609,700,372,247,723,721,95
95,1654,738,267,1625,292,977,75,721,1906,1987,1453,1287,372,1255,723,1730,1818,834,1989,63,247,2462,1821,71,396,261,2306,1740,1121,1635,1100,1271,700,1320,1032,1924,609,1244
2.3427776233754467,-0.1081959375724667,0.5211687621279207,1.3441112138985374,-0.09005424964602395,1.2370139309648251,0.3347961754544072,2.506054203043081,0.5362387937640063,-0.23791768452069523,-0.27588668305362396,0.01683561215363658,0.12049491179844807,1.0500310352209634,0.13746944516855703,0.5362387937640063,-0.1447...
3,282
Glycosphingolipid metabolic process
6
8
2.676052
0.00745
P04062,P06865,Q99805,P16278,P17900,P06280
Processes and pathways
GO Biological process
msigdb_gobp
145,113,84,54,246,184
145,184,113,335,54,246,1313,84
1.9573524101711695,1.6975470899868141,2.151887314605167,1.1386619873046315,2.712662399939541,1.4249475180109552,0.10343536726148002,2.4255716705252155
3,282
Organic acid transport
28
52
2.675199
0.007468
Q9UJS0,P30825,Q15758,P08195,O60831,P08183,Q96H78,Q9H2J7,P53985,P55011,Q9H2D1,Q9UBX3,P41440,Q9Y619,Q15041,P23786,Q8IWT6,Q8TDW0,P11166,Q7L0J3,P31751,O43772,Q6P4A7,O75915,Q96NB2,O14678,P28288,P04083
Processes and pathways
GO Biological process
msigdb_gobp
659,138,650,270,528,281,34,424,544,293,38,167,438,60,569,63,325,585,580,332,589,95,230,484,503,498,632,377
498,2686,3005,644,95,758,528,794,484,795,1507,2742,377,1601,2177,281,270,580,3089,1735,63,632,138,589,1863,438,2924,1481,544,293,2962,1003,1313,569,1460,650,2051,230,332,325,585,34,503,38,424,1405,752,167,659,1593,945,60
0.8101935073071703,-0.7446984489999219,-1.1111173323671646,0.6105758605037124,2.3427776233754467,0.5060299163255124,0.7684328524082645,0.47554353945259714,0.8377388499606527,0.47554353945259714,-0.018426654504152068,-0.7885304430072586,1.0371659946513645,-0.07200734605445942,-0.37265087688372656,1.2731201713397275,1.33...
3,282
Vacuole organization
17
48
2.675071
0.007471
P16615,Q14108,O75503,Q16706,Q9H0U4,P11117,Q6UWE0,P50897,P50851,Q6IAA8,P07686,P04062,O14773,P10253,P54802,O75787,Q8N511
Processes and pathways
GO Biological process
msigdb_gobp
384,3,36,451,526,103,442,44,474,399,335,145,81,372,185,471,29
1653,81,1623,36,471,1418,1331,145,926,335,372,103,384,949,673,474,44,1632,185,2440,1738,1336,546,1831,3,1460,1231,451,399,442,819,29,1272,1032,1466,788,2650,526,918,1721,1895,1534,973,2022,2657,629,2684,3181
-0.1081959375724667,2.4255716705252155,-0.09005424964602395,2.898255890365687,0.8650522301865151,0.03433177573533618,0.0862900538235537,1.9573524101711695,0.36658921531116717,1.1386619873046315,1.0500310352209634,2.283382339582687,1.0242489935338948,0.35073036585612155,0.5810414981125253,0.8650522301865151,2.8635099094...
3,282
Disproportionate short stature
10
26
2.648185
0.008093
Q9UHX1,Q14739,Q15392,Q8WVQ1,Q15125,Q9UBM7,Q7RTS9,P16278,Q9BV10,Q7LGA3
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
229,69,135,199,11,176,239,54,248,158
493,809,2853,603,690,54,2837,1511,673,1791,742,69,2637,11,135,421,1010,158,239,1712,199,263,2572,248,176,229
0.8239953918824245,0.46019487053471625,-0.900491564579252,0.6688615690298855,0.5661746186246456,2.712662399939541,-0.8778212232244633,-0.018426654504152068,0.5810414981125253,-0.18172843641255768,0.5211687621279207,2.576604864876466,-0.7013933032185452,3.424342931133359,2.0142460639311266,0.9720538608178498,0.318786007...
3,282
Golgi associated vesicle
8
31
2.645075
0.008167
P49755,P05067,P61923,P24390,Q99523,Q8TCT8,O43731,Q8N511
Localization
GO Cellular component
msigdb_gocc
386,169,397,45,342,150,27,29
1902,27,1983,1728,169,2178,3196,478,45,1422,1823,1791,386,2080,2822,2305,1738,397,1604,1869,899,29,150,1272,1613,342,1084,1567,1929,613,1092
-0.23791768452069523,2.9999531979248477,-0.27588668305362396,-0.144767223042154,1.8001335532224074,-0.37265087688372656,-1.6826967390281786,0.8514243186018405,2.821234068592441,0.03433177573533618,-0.20035758061349548,-0.18172843641255768,1.0242489935338948,-0.3142725349731669,-0.8552914666396761,-0.45202600377615704,-...
3,282
Organelle fusion
28
44
2.63875
0.008321
Q12981,Q13190,Q9H269,O95249,O60763,Q12846,P06493,Q8TB36,Q9Y4W6,O15400,Q86Y82,O60499,Q8N2A8,O60313,P51809,Q9Y6C9,Q8IWA4,Q9UJZ1,P31751,Q969V5,Q8WUH2,Q9NX63,Q9H300,Q9UNK0,P02786,Q99536,Q9GZY8,P04083
Processes and pathways
GO Biological process
msigdb_gobp
915,521,918,144,906,913,661,679,687,430,819,179,191,193,708,470,596,868,589,218,864,348,345,890,240,251,381,377
1652,430,193,2139,179,906,1623,1418,144,1331,240,377,661,926,2743,589,1632,2080,708,913,915,521,1058,1878,819,596,191,679,864,218,251,2650,381,918,345,1534,2623,348,2020,868,2022,890,687,470
-0.1081959375724667,0.9456346413788875,1.6555243256802743,-0.3530834233869732,1.738998392489689,0.3823733530740993,-0.09005424964602395,0.03433177573533618,1.9573524101711695,0.0862900538235537,1.4476634061842635,1.0371659946513645,0.5958417361485769,0.36658921531116717,-0.7885304430072586,0.6832728352514132,-0.0900542...
3,282
Rac3 gtpase cycle
8
33
2.635795
0.008394
Q9UQB8,Q8TAA9,Q14739,P50402,Q6IAA8,O15173,P02786,Q7L576
Processes and pathways
Reactome Pathways
msigdb_reactome
96,101,69,261,399,114,240,319
1652,114,737,240,1601,2304,479,261,1632,2309,1869,980,1552,2562,1262,1100,69,650,2115,1267,1217,1060,399,319,818,101,1144,2522,1374,1173,1220,96,1413
-0.1081959375724667,2.1429079626659977,0.5211687621279207,1.4476634061842635,-0.07200734605445942,-0.45202600377615704,0.8514243186018405,1.3790121380737033,-0.09005424964602395,-0.45202600377615704,-0.21908700961772024,0.3347961754544072,-0.03619440570372816,-0.6373991838940739,0.13746944516855703,0.25397254379079565,...
3,282
Inorganic anion transport
13
25
2.621815
0.008746
Q9NW15,Q8IWT6,P55011,Q9C0H2,Q9UBX3,P51790,P21796,Q9UHG3,P45880,O43826,P08183,P30536,Q9Y277
Processes and pathways
GO Biological process
msigdb_gobp
391,325,293,41,167,331,15,47,50,303,281,380,252
3163,639,303,281,15,380,50,331,583,1259,293,1550,1003,938,1395,325,585,41,391,167,47,252,945,3220,416
-1.5179982112659076,0.6252443929676549,1.2127112505391577,1.2731201713397275,3.223536276398023,1.0371659946513645,2.7420278978751074,1.1511243328250194,0.6976210318395957,0.13746944516855703,1.2370139309648251,-0.03619440570372816,0.31878600721311506,0.36658921531116717,0.05173904046404934,1.1759030599472666,0.69762103...
3,282
Endoplasmic reticulum organization
24
45
2.61641
0.008886
O43681,P57088,A0FGR8,O95197,Q9NQC3,Q96A33,P49069,Q15629,Q8NHH9,O00429,Q00765,Q15041,P50542,Q9P2W9,Q8N766,Q9H5V9,Q12907,Q5J8M3,Q8N5M9,Q8N4V1,O14657,P46379,Q15363,Q9NPA0
Processes and pathways
GO Biological process
msigdb_gobp
639,779,775,160,165,299,308,51,434,808,439,569,694,62,846,715,593,729,217,223,871,122,899,256
775,808,871,1249,1047,2688,639,1383,1754,160,2239,122,308,694,779,1023,2380,439,593,915,1264,569,1460,899,51,729,1057,1031,223,217,846,1167,434,299,1173,2323,1721,715,1036,1497,256,165,1376,1849,62
0.4908216973007541,0.46019487053471625,0.41371997306172403,0.13746944516855703,0.28653515071813196,-0.7446984489999219,0.6252443929676549,0.05173904046404934,-0.1631986289661192,1.8797704164389588,-0.41211517468133246,2.0975965576515088,1.2127112505391577,0.5661746186246456,0.4908216973007541,0.30269921647967324,-0.492...
3,282
Sphingolipid biosynthetic process
9
16
2.609566
0.009066
Q6ZMG9,O15269,P27544,O95470,Q13510,P04062,Q99805,Q06136,Q96G23
Processes and pathways
GO Biological process
msigdb_gobp
448,257,37,133,46,145,84,120,90
257,1380,133,145,1990,37,120,1313,46,2222,448,90,84,1376,527,1849
1.390559620323408,0.05173904046404934,2.0236236192967936,1.9573524101711695,-0.27588668305362396,2.8913413666749483,2.1158046507689834,0.10343536726148002,2.792690291492383,-0.3923277640646288,0.9055948775740706,2.3844709040308296,2.4255716705252155,0.06905820401443656,0.7824126866297165,-0.20035758061349548
3,282
Abnormal retinal artery morphology
10
23
2.595314
0.00945
P10619,P03886,Q9NZJ7,Q13510,P07686,P07602,P06865,P16278,P17900,P21964
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
72,75,301,46,335,209,113,54,246,379
1982,1250,1282,75,721,113,209,335,72,2607,54,246,379,2034,2669,1739,46,883,2521,2420,301,1897,415
-0.27588668305362396,0.13746944516855703,0.12049491179844807,2.506054203043081,0.5362387937640063,2.151887314605167,1.5805666593769274,1.1386619873046315,2.537625343517015,-0.6799348090885988,2.712662399939541,1.4249475180109552,1.0371659946513645,-0.29502699624958933,-0.7229807232924671,-0.144767223042154,2.7926902914...
3,282
Mitochondrial respiratory chain complex assembly
13
41
2.595217
0.009453
O43674,Q96CU9,Q9P0J0,P03886,O75306,O95831,Q6DKK2,O95169,O43676,Q69YU5,Q9Y2R0,Q15070,Q9H061
Processes and pathways
GO Biological process
msigdb_gobp
316,66,107,75,267,237,146,305,21,86,24,216,64
316,21,3164,1019,2555,267,2174,477,740,305,2836,237,1656,75,721,2695,1866,2749,2939,216,2343,746,86,146,652,1490,862,1747,66,600,2806,64,346,1806,1244,1069,107,1780,24,458,2260
1.188220112815457,3.129951513482956,-1.5179982112659076,0.30269921647967324,-0.6373991838940739,1.3441112138985374,-0.37265087688372656,0.8514243186018405,0.5211687621279207,1.2127112505391577,-0.8778212232244633,1.4589593479977,-0.1081959375724667,2.506054203043081,0.5362387937640063,-0.7446984489999219,-0.21908700961...
3,282
Protein targeting to mitochondrion
16
51
2.583161
0.00979
Q9NS69,Q10713,Q99595,Q8N4H5,O60830,Q9P0J0,Q15388,O95831,P30536,O14737,P55786,Q9Y584,O43615,P51572,Q9H300,O14925
Processes and pathways
GO Biological process
msigdb_gobp
0,227,4,5,10,107,202,237,380,143,82,57,282,313,345,253
1179,143,253,282,924,10,2719,2075,1418,2690,1285,237,1000,831,2891,1946,380,2790,2037,313,82,2040,227,1313,202,2278,960,2222,635,1878,5,1747,679,1678,2574,4,540,3073,381,345,2868,0,107,2134,2166,629,2168,458,57,905,2025
0.18789041292229028,1.9573524101711695,1.402064492860211,1.2611307098563012,0.36658921531116717,3.4356976780399577,-0.7665478813310426,-0.3142725349731669,0.03433177573533618,-0.7446984489999219,0.12049491179844807,1.4589593479977,0.31878600721311506,0.4447751115533682,-0.9462602777918803,-0.25685057969960273,1.0371659...
3,282
Secondary active transmembrane transporter activity
13
22
2.579812
0.009885
Q9H2J7,Q8NE86,P53985,P55011,Q9UBX3,P51798,O95202,P51790,P08195,O43826,P41440,P12236,Q9Y6M7
Functions
GO Molecular function
msigdb_gomf
424,488,544,293,167,583,394,331,270,303,438,378,416
303,394,853,270,1255,378,438,331,583,1481,544,293,1550,1003,650,488,1012,424,1405,167,945,416
1.2127112505391577,1.0112796586421209,0.4292836766633106,1.3323904602126717,0.13746944516855703,1.0371659946513645,0.9189967934039461,1.1511243328250194,0.6976210318395957,-0.0007502583674914466,0.740292053869216,1.2370139309648251,-0.03619440570372816,0.31878600721311506,0.6105758605037124,0.8377388499606527,0.3187860...
3,282
Steroid biosynthesis
9
12
2.576539
0.00998
P38571,Q15392,Q15125,Q9UBM7,Q14534,Q15800,O75845,Q16850,P37268
Processes and pathways
KEGG Pathways
msigdb_kegg
100,135,11,176,210,89,405,183,31
405,620,31,100,418,210,11,135,1917,89,183,176
0.9982576128879851,0.6543867400016848,2.9529597638291984,2.3089861165903924,0.9720538608178498,1.5697074338437027,3.424342931133359,2.0142460639311266,-0.23791768452069523,2.3927379782175318,1.7183433107459631,1.769720066961587
3,282
SLC25 family of mitochondrial transporters
14
21
2.572852
0.010086
O43808,Q96H78,Q9UJS0,Q9H2D1,Q9UBX3,Q9Y6C9,Q70HW3,Q9NZJ7,Q6NUK1,Q6KCM7,P12236,Q9HC21,Q9Y619,O43772
Drugs and Diseases
Pharos Drug Target Ontology
pharos_dto
758,34,659,38,167,470,13,301,783,730,378,772,60,95
95,758,794,853,1255,378,1481,1550,1003,730,783,13,34,38,1405,772,301,167,659,60,470
2.3427776233754467,0.5060299163255124,0.47554353945259714,0.4292836766633106,0.13746944516855703,1.0371659946513645,-0.0007502583674914466,-0.03619440570372816,0.31878600721311506,0.5362387937640063,0.4908216973007541,3.319910808935396,2.939384808405215,2.8844095835048527,0.05173904046404934,0.5060299163255124,1.224885...
3,282
Mitochondrial substrate/solute carrier [IPR018108]
14
21
2.572852
0.010086
O43808,Q96H78,Q9UJS0,Q9H2D1,Q9UBX3,Q9Y6C9,Q70HW3,Q9NZJ7,Q6NUK1,Q6KCM7,P12236,Q9HC21,Q9Y619,O43772
Sequence
InterPro Repeat
interpro_repeat
758,34,659,38,167,470,13,301,783,730,378,772,60,95
95,758,794,853,1255,378,1481,1550,1003,730,783,13,34,38,1405,772,301,167,659,60,470
2.3427776233754467,0.5060299163255124,0.47554353945259714,0.4292836766633106,0.13746944516855703,1.0371659946513645,-0.0007502583674914466,-0.03619440570372816,0.31878600721311506,0.5362387937640063,0.4908216973007541,3.319910808935396,2.939384808405215,2.8844095835048527,0.05173904046404934,0.5060299163255124,1.224885...
3,282
Mitochondrial carrier domain superfamily [IPR023395]
14
21
2.572852
0.010086
O43808,Q96H78,Q9UJS0,Q9H2D1,Q9UBX3,Q9Y6C9,Q70HW3,Q9NZJ7,Q6NUK1,Q6KCM7,P12236,Q9HC21,Q9Y619,O43772
Sequence
InterPro Superfamily
interpro_homologous_superfamily
758,34,659,38,167,470,13,301,783,730,378,772,60,95
95,758,794,853,1255,378,1481,1550,1003,730,783,13,34,38,1405,772,301,167,659,60,470
2.3427776233754467,0.5060299163255124,0.47554353945259714,0.4292836766633106,0.13746944516855703,1.0371659946513645,-0.0007502583674914466,-0.03619440570372816,0.31878600721311506,0.5362387937640063,0.4908216973007541,3.319910808935396,2.939384808405215,2.8844095835048527,0.05173904046404934,0.5060299163255124,1.224885...
3,282
Endoplasmic reticulum golgi intermediate compartment membrane
17
23
2.569442
0.010186
Q10472,Q08379,Q9Y3B3,Q15904,Q9H0U4,P49755,O95070,Q13190,P24390,Q9Y282,P61019,Q12907,O15498,Q96RQ1,Q9Y3A6,P51572,Q8N511
Localization
GO Cellular component
msigdb_gocc
390,640,613,262,526,386,321,521,45,78,780,593,737,219,807,313,29
1476,737,1623,321,45,2746,386,313,813,780,640,390,593,521,899,262,29,219,1084,526,78,807,613
-0.0007502583674914466,0.5211687621279207,-0.09005424964602395,1.1759030599472666,2.821234068592441,-0.7885304430072586,1.0242489935338948,1.2004894005422622,0.46019487053471625,0.4908216973007541,0.6252443929676549,1.0242489935338948,0.6832728352514132,0.7824126866297165,0.3980834008801064,1.3790121380737033,2.9932887...
3,282
Cherry red spot of the macula
7
9
2.564035
0.010346
P10619,Q9NZJ7,Q13510,P07602,P06865,P16278,P17900
Drugs and Diseases
Human Phenotype Ontology
msigdb_hp
72,301,46,209,113,54,246
113,209,335,72,2607,54,246,46,301
2.151887314605167,1.5805666593769274,1.1386619873046315,2.537625343517015,-0.6799348090885988,2.712662399939541,1.4249475180109552,2.792690291492383,1.2248859870045634
3,282
Organic acid transmembrane transporter activity
16
23
2.558482
0.010513
Q9H9B4,Q96H78,Q9H2J7,O95563,Q9UJS0,P53985,Q9H2D1,Q9UBX3,P30825,Q15758,P08195,Q96NB2,O14975,P41440,P08183,Q9Y619
Functions
GO Molecular function
msigdb_gomf
752,34,424,795,659,544,38,167,138,650,270,503,644,438,281,60
2686,644,794,795,281,270,138,438,1481,544,1003,650,2051,34,503,38,424,1405,752,167,659,945,60
-0.7446984489999219,0.6105758605037124,0.47554353945259714,0.47554353945259714,1.2731201713397275,1.3323904602126717,1.9954018657539796,0.9189967934039461,-0.0007502583674914466,0.740292053869216,0.31878600721311506,0.6105758605037124,-0.29502699624958933,2.939384808405215,0.8101935073071703,2.8844095835048527,0.972053...
3,282
Secondary alcohol metabolic process
17
45
2.554732
0.010627
Q14739,Q9BQE5,Q15392,P48449,P16435,P05067,Q15125,P49748,Q9UBM7,P04062,Q8WTV0,Q14534,Q15800,O75845,Q16850,Q14849,P37268
Processes and pathways
GO Biological process
msigdb_gobp
69,6,135,418,265,169,11,396,176,145,49,210,89,405,183,250,31
417,2371,2720,405,1624,1783,2763,3167,145,169,1659,833,265,2956,620,31,2959,418,1136,396,3158,1954,3052,840,1913,2111,2146,1313,2942,210,69,250,1525,11,2860,135,1917,89,183,1124,49,3106,6,176,1112
0.9720538608178498,-0.4923924005392478,-0.7665478813310426,0.9982576128879851,-0.09005424964602395,-0.18172843641255768,-0.8106475789227858,-1.544956106951877,1.9573524101711695,1.8001335532224074,-0.1081959375724667,0.4447751115533682,1.367421765529877,-1.0395551932285616,0.6543867400016848,2.9529597638291984,-1.03955...
3,282
Steroid binding
10
23
2.551077
0.010739
O00264,Q14108,O95772,P30536,P21796,P04062,P45880,O15173,P38435,Q14849
Functions
GO Molecular function
msigdb_gomf
224,3,137,380,15,145,50,114,55,250
224,417,114,2720,1783,137,145,810,2105,15,1990,2514,380,620,55,50,840,3,250,1014,2502,969,2505
1.5148295730982289,0.9720538608178498,2.1429079626659977,-0.7665478813310426,-0.18172843641255768,2.0048388682504683,1.9573524101711695,0.46019487053471625,-0.33362432918571483,3.223536276398023,-0.27588668305362396,-0.5953632204872029,1.0371659946513645,0.6543867400016848,2.712662399939541,2.7420278978751074,0.4447751...
3,282
Respiratory chain
11
34
2.55084
0.010746
Q96CU9,O14949,Q9UDW1,P00403,Q9P0J0,P03886,O75306,Q6DKK2,O43676,O95169,Q9Y241
Processes and pathways
Protein Atlas Biological process
protein_atlas_biological_process
66,35,68,292,107,75,267,146,21,305,56
1725,35,316,21,3164,2555,267,2174,740,305,3217,2836,1656,292,75,721,1254,3120,837,2695,2920,1866,3202,2749,2343,746,146,1490,66,1244,107,68,56,2260
-0.144767223042154,2.9120334629969933,1.188220112815457,3.129951513482956,-1.5179982112659076,-0.6373991838940739,1.3441112138985374,-0.37265087688372656,0.5211687621279207,1.2127112505391577,-1.8255957659988549,-0.8778212232244633,-0.1081959375724667,1.2370139309648251,2.506054203043081,0.5362387937640063,0.1374694451...
3,282
Sphingolipid metabolism integrated pathway
6
8
2.542627
0.011002
O15269,P27544,O95470,Q13510,Q06136,Q96G23
Processes and pathways
WikiPathways
msigdb_wp
257,37,133,46,120,90
257,1380,133,37,120,46,448,90
1.390559620323408,0.05173904046404934,2.0236236192967936,2.8913413666749483,2.1158046507689834,2.792690291492383,0.9055948775740706,2.3844709040308296
3,282
Sphingolipid metabolism overview
6
8
2.542627
0.011002
O15269,P27544,O95470,Q13510,Q06136,Q96G23
Processes and pathways
WikiPathways
msigdb_wp
257,37,133,46,120,90
257,1380,133,37,120,46,448,90
1.390559620323408,0.05173904046404934,2.0236236192967936,2.8913413666749483,2.1158046507689834,2.792690291492383,0.9055948775740706,2.3844709040308296
3,282
Serine hydrolase activity
8
20
2.518989
0.011769
P10619,P67812,Q9HB40,O14773,Q4J6C6,O75976,Q9H3G5,P42785
Functions
GO Molecular function
msigdb_gomf
72,106,12,81,338,304,19,20
81,304,72,1944,2584,893,20,1910,1793,813,106,559,338,635,817,1463,2007,345,19,12
2.4255716705252155,1.2127112505391577,2.537625343517015,-0.25685057969960273,-0.6586038820934165,0.3980834008801064,3.142617455562031,-0.23791768452069523,-0.18172843641255768,0.46019487053471625,2.2747975061979706,0.7261301615080007,1.1261505340235223,0.6398478494370026,0.46019487053471625,0.01683561215363658,-0.27588...
3,282
Exopeptidase activity
11
33
2.518946
0.011771
P10619,Q9HB40,Q9UIQ6,O75844,O14773,P55786,Q9H3G5,P42785,P02786,Q9NZ08,P36551
Functions
GO Molecular function
msigdb_gomf
72,12,111,80,81,82,19,20,240,117,247
81,80,304,240,1454,72,3006,2787,2584,247,20,3051,1197,813,82,3208,1872,531,2007,2155,413,749,3271,901,2423,19,2808,12,2653,2831,1928,117,111
2.4255716705252155,2.4499538883891847,1.2127112505391577,1.4476634061842635,0.01683561215363658,2.537625343517015,-1.1111173323671646,-0.8329007565972378,-0.6586038820934165,1.4249475180109552,3.142617455562031,-1.184096314811162,0.18789041292229028,0.46019487053471625,2.4255716705252155,-1.7392183386063267,-0.21908700...
3,282
Late endosome membrane
9
29
2.499825
0.012425
Q14108,O15118,O95772,P51790,Q6IAA8,Q8TCT8,Q14849,Q8IV08,Q9BXS4
Localization
GO Cellular component
msigdb_gocc
3,417,137,331,399,150,250,59,221
2261,429,417,137,926,2105,978,723,1632,331,708,3,250,399,59,150,1032,1014,2500,2502,221,970,918,717,1688,1534,2022,890,2852
-0.4320142141361126,0.9456346413788875,0.9720538608178498,2.0048388682504683,0.36658921531116717,-0.33362432918571483,0.3347961754544072,0.5362387937640063,-0.09005424964602395,1.1511243328250194,0.5512405638431472,3.4972936020541496,1.4135270336371222,1.0112796586421209,2.682987626080082,1.9284939850101928,0.302699216...
3,282
Cation transmembrane transporter activity
42
69
2.49703
0.012524
P16615,Q9NW15,O43808,Q9Y487,P30825,O95202,Q70HW3,Q15758,P08195,O75964,P21281,Q93050,P98194,P13073,P20674,Q9UM00,Q9Y6M7,Q9H2J7,O14548,P55011,P00403,P24539,P36542,Q9HD20,Q9Y619,P36543,P23634,Q9UDW1,P51790,P06576,Q93034,P56385,Q8N4V1,O43772,Q9H9B4,Q8NE86,Q13423,Q6P4Q7,P20020,Q96NB2,Q9H0U3,Q9HC21
Functions
GO Molecular function
msigdb_gomf
384,391,758,264,138,394,13,650,270,17,778,149,407,153,663,541,416,424,793,293,292,170,672,188,60,693,565,68,331,205,732,215,223,95,752,488,238,242,618,503,771,772
793,95,758,2266,17,394,292,810,1117,853,205,926,2105,270,1254,2211,1255,153,2919,384,618,663,778,3176,565,170,2179,138,2920,672,693,1789,1866,1576,331,293,1359,215,1825,2380,407,1550,2877,238,650,938,242,13,223,488,1012,732,149,1589,503,771,424,1405,752,772,188,391,68,1690,541,945,264,60,416
0.47554353945259714,2.3427776233754467,0.5060299163255124,-0.4320142141361126,3.186489069229093,1.0112796586421209,1.2370139309648251,0.46019487053471625,0.23757265698845073,0.4292836766633106,1.6021706965552707,0.36658921531116717,-0.33362432918571483,1.3323904602126717,0.13746944516855703,-0.3923277640646288,0.137469...
3,282
Liposaccharide metabolic process
12
16
2.494895
0.012599
P04066,O60762,P07686,P04062,P06865,Q99805,P16278,P17900,O43292,P06280,Q969N2,Q8NBX0
Processes and pathways
GO Biological process
msigdb_gobp
322,578,335,145,113,84,54,246,311,184,573,28
311,578,145,322,184,113,335,54,246,1313,28,608,573,769,84,803
1.2004894005422622,0.6976210318395957,1.9573524101711695,1.1759030599472666,1.6975470899868141,2.151887314605167,1.1386619873046315,2.712662399939541,1.4249475180109552,0.10343536726148002,2.9999531979248477,0.6688615690298855,0.7119066464917171,0.5060299163255124,2.4255716705252155,0.47554353945259714
3,282
Slc mediated transmembrane transport
13
21
2.483601
0.013006
Q9H2J7,P53985,P55011,Q9UBX3,P30825,Q8TB61,P11166,Q70HW3,P08195,P36404,P35613,P12236,Q9Y6M7
Processes and pathways
Reactome Pathways
msigdb_reactome
424,544,293,167,138,139,580,13,270,18,312,378,416
853,270,580,1255,378,2789,138,312,18,544,293,650,2051,13,139,1012,424,1405,167,945,416
0.4292836766633106,1.3323904602126717,0.6976210318395957,0.13746944516855703,1.0371659946513645,-0.8329007565972378,1.9954018657539796,1.2004894005422622,3.186489069229093,0.740292053869216,1.2370139309648251,0.6105758605037124,-0.29502699624958933,3.319910808935396,1.976437767564253,0.31878600721311506,0.9720538608178...
3,282