Search is not available for this dataset
text
stringlengths
0
214k
source
stringclasses
15 values
Efficacy and Safety of NS2359 in Adults With Attention Deficit Hyperactivity Disorder Study Overview ================= Brief Summary ----------------- The purpose of the study is to investigate if NS2359 is effective in the treatment of ADHD in adult patients. Official Title ----------------- Efficacy and Safety of N...
ctgov
Gastric Emptying of Rice With Different Starch Properties Study Overview ================= Brief Summary ----------------- Glycemic carbohydrates are associated with metabolic disturbances, such as type II diabetes, due to rapid digestion of starch into glucose. The specific properties of starch within these foods has...
ctgov
Practice Facilitation to Scale up a CDS for Hypertension Management Study Overview ================= Brief Summary ----------------- Hypertension (HTN) is the most prevalent modifiable risk factor for cardiovascular disease among U.S. adults. Despite a long history of established guidelines to support clinical managem...
ctgov
Food Effect on Pharmacokinetic Parameters of ABX464 Study Overview ================= Brief Summary ----------------- The goal of this study is to determine the impact of the food on the absorption of the ABX464. Detailed Description ----------------- This is a phase I, single-center, open-label, two-treatment, food-e...
ctgov
Effect of Spinal Manipulation on Electromyography of the Masseter Muscle Study Overview ================= Brief Summary ----------------- Research Problem: To know the immediate effects of high speed and low amplitude cervical manipulation on the electromyographic activity of the masseter muscles of physiotherapy stud...
ctgov
Hypothermic Oxygenated (HOPE) Versus Normothermic Machine Perfusion (NMP) in Human Liver Transplantation Study Overview ================= Brief Summary ----------------- The common practice of conventional cold storage (CCS) organ preservation has changed little since the initial introduction of the original Universit...
ctgov
Effects of Cord Blood 25-hydroxy-vitamin D Level on Early Neonatal Morbidities Study Overview ================= Brief Summary ----------------- Cholecalciferol (vitamin D3) is a prohormone and its active form is 1,25 dihydroxycholecalciferol. This hormone has effect on both calcium, phosphorus and bone metabolism and ...
ctgov
MyPhonak App Junior Pediatric Usability and Benefit Investigation Study Overview ================= Brief Summary ----------------- ESolutions functions for children and young people with the myPhonak app is a prospective study to investigate whether the myPhonak app can improve speech understanding in children with he...
ctgov
Study of REGN3500 and Dupilumab in Patients With Asthma Study Overview ================= Brief Summary ----------------- To assess the effects of REGN3500, dupilumab, and REGN3500 plus dupilumab, compared with placebo, on changes in inflammatory gene expression signatures in sputum induced after a bronchial allergen c...
ctgov
Radiotherapy Alone Versus Concurrent Chemoradiation in Low Risk NK/T-cell Lymphoma Study Overview ================= Brief Summary ----------------- The purpose of this study is to prove the superiority of concurrent chemoradiation compared with radiotherapy alone in patients with low risk NK/T-cell lymphoma. Detailed...
ctgov
Effectiveness of Positive Psychotherapy on Mental Wellbeing Among Caregivers of Cerebral Palsy Children Study Overview ================= Brief Summary ----------------- The Central idea of the proposed research proposal is first to translate adapt and validate the Caregiver Difficulties Scale & Positive Psychotherapy ...
ctgov
Model for Safety Culture by Empowering the Family at Home: a Mixed-methods Study Protocol Study Overview ================= Brief Summary ----------------- Background: The elderly are a vulnerable group for health problems as they age. Safe care is essential when caring for the elderly at home because adverse events ca...
ctgov
Multicenter RCT of ADV-TK Gene Therapy Improving the Outcome of Liver Transplantation for Advanced HCC Study Overview ================= Brief Summary ----------------- Compare the effect of liver transplantation (LT) plus ADV-TK gene therapy versus LT only in advanced primary hepatocellular carcinoma. Official Title ...
ctgov
The Effects on Blood Pressure Control, Pulse Wave Velocity, as Well as Safety and Tolerability of Felodipine Sustained Release in Chinese Patients. Study Overview ================= Brief Summary ----------------- The purpose of this study is to evaluate the effects on blood pressure control, pulse wave velocity, as we...
ctgov
Interscalene Brachial Plexus Block to Treat Pain After Clavicular Surgery Study Overview ================= Brief Summary ----------------- The sensory innervation of the clavicle remains an area of debate. Regional nerve blocks aimed at relieving pre- and post-operative pain include the superficial cervical plexus blo...
ctgov
Circulating Tumor Cells (CTCs): A Potential Screening Test for Clinically Undetectable Breast Carcinoma Study Overview ================= Brief Summary ----------------- With an estimated > 2 million women with undetected breast cancer in the United States, the need for improved early detection is imperative. Early dia...
ctgov
A Phase III Study of BKM120 With Fulvestrant in Patients With HR+,HER2-, AI Treated, Locally Advanced or Metastatic Breast Cancer Who Progressed on or After mTORi Study Overview ================= Brief Summary ----------------- This study was a multicenter, randomized, double-blind, placebo-controlled Phase III study ...
ctgov
Pre-, Peri- and Postnatal Programming and Origins of Disease: Early Targeting the Epidemics of Allergy and Overweight Study Overview ================= Brief Summary ----------------- Combined programme: Nutrition, Allergy, Mucosal immunology and Intestinal microbiota (NAMI) was created with the objective to reverse th...
ctgov
Effect of Ranibizumab Versus Bevacizumab on the Macular Perfusion in Diabetic Macular Edema Study Overview ================= Brief Summary ----------------- The Early Treatment Diabetic Retinopathy Study (ETDRS) group founded guidelines for treating patients with clinically significant diabetic macular edema (DME) wit...
ctgov
Predictive Value of the Distress Thermometer as a Predictive Screening Instrument to Detect Cancer-related Cognitive Impairment in Cancer Patients Study Overview ================= Brief Summary ----------------- Cognitive impairment associated with chemotherapy is an important reported post-treatment side-effect among...
ctgov
A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria. Study Overview ================= Brief Summary ----------------- A Phase 3 comparative study t...
ctgov
Lisocabtagene Maraleucel (JCAR017) as Second-Line Therapy (TRANSCEND-PILOT-017006) Study Overview ================= Brief Summary ----------------- This is a Phase 2, open-label, multicenter study to determine the efficacy and safety of lisocabtagene maraleucel (JCAR017) in adult subjects who have relapsed from, or ar...
ctgov
Relationship Between ALDH2 and CIN Study Overview ================= Brief Summary ----------------- The purpose of this clinical trial is to investigate the relationship between the gene polymorphism of aldehyde dehydrogenase 2 and contrast induced nephropathy and its mechanism. Detailed Description -----------------...
ctgov
A Study of Brentuximab Vedotin in Participants With Relapsed or Refractory Hodgkin Lymphoma Study Overview ================= Brief Summary ----------------- This phase 4, single-arm, open-label, multicenter study is designed to evaluate the efficacy and safety of brentuximab vedotin as a single agent in adult particip...
ctgov
Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Study Overview ================= Brief Summary ----------------- This pilot phase II trial studies how well vincristine sulfate liposome works in treating patients with acute myeloid leukemia that has returned after a ...
ctgov
Parental Project and Premature Ovarian Insufficiency Study Overview ================= Brief Summary ----------------- One of the main repercussions of POI is infertility. When the diagnosis of POI is announced, the question of fertility is addressed and the patient is often directed towards egg donation or adoption wh...
ctgov
One-piece and Two-piece Zirconia Abutments in Single Implant Crowns in Esthetic Region Study Overview ================= Brief Summary ----------------- The goal of this clinical trail is to evaluate the clinical, radiological and immunological outcomes of the one-piece zirconia abutments (OPZAs) and two-piece zirconia...
ctgov
Rapid Evaluation of Acute Kidney Injury With NGAL in Acutely Ill Patients in the ICU Study Overview ================= Brief Summary ----------------- This is a multi-center, prospective, observational study of patients that are admitted to the intensive care unit (ICU). This study does not include any treatment or int...
ctgov
Studies of Kidney Transplant Outcome Study Overview ================= Brief Summary ----------------- The purpose of this study is to improve outcome for kidney transplant recipients. There has not been commensurate improvement in medium and long-term outcomes. Ongoing clinical research is necessary to improve transpl...
ctgov
Study for HER2-Overexpressed MBC Patients Treated by Cipterbin® Plus vinorelbinE Study Overview ================= Brief Summary ----------------- Breast cancer is the most common malignant disease and the most frequent causes of cancer mortality in females worldwide. The situation is same as the world in China. Trastu...
ctgov
Evaluation of Low Blood Sugar Events in Participants With Diabetes (MK-0431-402) Study Overview ================= Brief Summary ----------------- This is a multicenter, observational, retrospective and cross-sectional study to be conducted in a cohort of consecutively selected participants with type 2 diabetes mellitu...
ctgov
Spinal Cord Stimulation in Heart Failure Study Overview ================= Brief Summary ----------------- Previous studies have shown that spinal cord stimulation (SCS) may improve cardiac output and decrease the risk of ischemic ventricular arrhythmia in animal model and its safety profile in human trial. The purpose...
ctgov
Comparison of BiPAP and ٰIS in Reducing Post CABG Pulmonary Complications Study Overview ================= Brief Summary ----------------- To evaluate the effect of Bi-level Positive Airway Pressure (BiPAP) and Incentive Spirometry (IS) in post CABG patients. Detailed Description ----------------- As postoperative pu...
ctgov
Understanding Methotrexate Induced Gastrointestinal Intolerance in Juvenile Idiopathic Arthritis and Childhood Leukemia Study Overview ================= Brief Summary ----------------- Methotrexate is a cornerstone in the treatment of childhood leukemia. When given in high-dose as part of the initial phase of treatmen...
ctgov
Single Ascending Dose Study With Healthy Male Volunteers and Type II Diabetic Patients Study Overview ================= Brief Summary ----------------- The purpose of this study is to assess safety and tolerability of AZD6714 after single ascending oral doses in healthy male subjects and type 2 diabetic patients. Off...
ctgov
Pancreaticogastrostomy Versus Pancreaticojejunostomy in Reconstruction After Cephalic Duodenopancreatectomy Study Overview ================= Brief Summary ----------------- Pancreaticoduodenectomy is the standards surgical procedure for various malignant and benign disease of the pancreas and periampullariy region. Du...
ctgov
Determination of Physical Activity Status and Adherence to the Mediterranean Diet in Adults and Related Health Outcomes Study Overview ================= Brief Summary ----------------- A physically active life with adequate and balanced nutrition is essential for a healthy life. Unhealthy diet and being physically ina...
ctgov
Dose Finding Study of HP802-247 in Venous Leg Ulcers Study Overview ================= Brief Summary ----------------- This is a 16-week study for subjects with a venous leg ulcer between the knee and ankle. This research is being done to determine the effectiveness of two dosing frequencies and two different concentra...
ctgov
Expression of HOXA10 and HOXA11 in the Endometrium of Infertility Patients With an Endometrial Polyp Before and After Polypectomy Study Overview ================= Brief Summary ----------------- The aim of this study is to measure the expression of HOXA10 and HOXA11 in the endometrium of infertility patients with an e...
ctgov
Reliability and Validity of the 2-Minute Step Test in Patients With Knee Arthroplasty Study Overview ================= Brief Summary ----------------- Total knee arthroplasty (TKA) is a cost-effective treatment for end-stage knee osteoarthritis. It has demonstrable benefits such as reducing pain and improving activity...
ctgov
Comparison of Mid-term Results of Total Correction of TOF Between Preservation of PV and Trans-annular Patch. Study Overview ================= Brief Summary ----------------- To compare of mid-term results of total correction of tetralogy of fallot between preservation of pulmonary valve and trans-annular patching , t...
ctgov
A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma Study Overview ================= Brief Summary ----------------- This is a multi-center, double-blind, randomized, phase III study to investigate the efficacy and safety of Nofazinlimab (CS1003) in combination with lenvatinib and place...
ctgov
Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India Study Overview ================= Brief Summary ----------------- According to the World Health Organization, lymphatic filariasis, a mosquito-borne parasitic disease, is the second leading cause of disability worldwide. Across...
ctgov
Metformin and Nightly Fasting in Women With Early Breast Cancer Study Overview ================= Brief Summary ----------------- This phase IIb trial studies the combined effect of prolonged nightly fasting and metformin hydrochloride extended release in decreasing breast tumor cell proliferation and other biomarkers ...
ctgov
Effect Evaluation of Individual Placement and Support (IPS) Study Overview ================= Brief Summary ----------------- Roughly one third of disability pensions issued in Norway are classified as mental and behavioral disorders. The proposed study aims to evaluate the effect of an innovative intervention for retu...
ctgov
A Study to Evaluate the Effect of MK-8669 (Ridaforolimus) on QTc Interval in Participants With Advanced Cancer (MK-8669-037) Study Overview ================= Brief Summary ----------------- To assess the potential for ridaforolimus to prolong the QTc interval (an effect on the electrical activity of the heart) in part...
ctgov
Percutaneous Neuromodulation on the Anterior Pain Knee Study Overview ================= Brief Summary ----------------- Anterior knee pain (AKP) is one of the most frequent pathologies of the lower limb, in young and adult subjects. In the field of Physiotherapy, ultrasound-guided Percutaneous Neuromodulation (PNM) is...
ctgov
The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer Study Overview ================= Brief Summary ----------------- The human oral cavity is a diverse habitat that contains approximately 700 prokaryotic species. The oral microbiome is comprised of 44% named species, 12% isolates representing unnamed spec...
ctgov
Amitiza in Constipation Associated With PD (Parkinson's Disease) Study Overview ================= Brief Summary ----------------- The purpose of this study is to determine if Amitiza (lubiprostone), a drug proven to be safe and effective for chronic constipation, will also improve constipation symptoms in Parkinson's ...
ctgov
Randomized Controlled Trial of Acupuncture for Functional Dyspepsia Study Overview ================= Brief Summary ----------------- The purpose of the study is to testify the efficacy of treating functional dyspepsia with acupuncture, and provide evidence for the hypothesis that Acupuncture effect is based on meridia...
ctgov
Study of Erythropoietin in Newborns and Children Study Overview ================= Brief Summary ----------------- Erythropoietin (EPO) is a glycoprotein hormone with a molecular weight of 30.4 kDa, responsible for regulating erythropoiesis in adults, newborns and fetuses. During pregnancy, the concentration of materna...
ctgov
Combined Transcranial Magnetic Stimulation and Cognitive Treatment in Blast Traumatic Brain Injury Study Overview ================= Brief Summary ----------------- This study investigates the efficacy of a novel neurorehabilitation program combining noninvasive brain stimulation (transcranial magnetic stimulation or T...
ctgov
Understanding Male Breast Cancer: Salah Azaïz Cancer Institute Experience Study Overview ================= Brief Summary ----------------- The goal of this study is to evaluate the Salah Azaïz Cancer Institute male breast cancer patients population over a period of 14 years. Goal of the retrospective part: to gather c...
ctgov
Efficacy of Imipramine for Treatment of Patients With Esophageal Hypersensitivity/ Functional Heartburn Study Overview ================= Brief Summary ----------------- Esophageal hypersensitivity/Functional heartburn are common among non-erosive reflux disease (NERD) patients who do not response to proton pump inhibi...
ctgov
Hospital Outcomes: Intervention in Moderately III Patients Study Overview ================= Brief Summary ----------------- To evaluate the utility of real time prognostic data (illness severity, stability and function) in the improvement of hospitalization morbidity, mortality, iatrogenic complications and length of ...
ctgov
Evaluation of Treatment Option for Demodicosis in Patients Undergoing Cataract Surgery Study Overview ================= Brief Summary ----------------- Demodex blepharitis is a prevalent cause of comorbid infection among individuals undergoing cataract surgery. Several complications may arise in the postsurgical perio...
ctgov
Study of the Effect of Innate on the Inflammatory Response to Endotoxin Study Overview ================= Brief Summary ----------------- Background: - Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Res...
ctgov
Epithelial Ovarian Cancer- Staging and Response to Chemotherapy Evaluated by PET/CT Study Overview ================= Brief Summary ----------------- The purpose of this study is to determine, whether there is clinical benefit of using fdg-PET/CT (F-18-fluorodeoxyglucose- positron emission tomography/computed tomograph...
ctgov
Stem Cell Therapy in Traumatic Brain Injury Study Overview ================= Brief Summary ----------------- The purpose of this study was to study the effect of stem cell therapy on common symptoms in patients with Traumatic Brain Injury Official Title ----------------- Open Label Study of Autologous Bone Marrow Mon...
ctgov
Tenofovir in Asian Chronic Hepatitis B Patients Study Overview ================= Brief Summary ----------------- Tenofovir (TDF) has been demonstrated to have potency antiviral against the hepatitis B virus (HBV) in various multiple-centre trials, with no cases of resistance encountered. However, its efficacy and resi...
ctgov
Stress and Health Interview for Primary Care Patients With Medically Unexplained Symptoms Study Overview ================= Brief Summary ----------------- The goal of this study is to test the feasibility and acceptability of providing an experiential assessment interview that targets emotional and stressful experienc...
ctgov
Effect of Ciprofol Infusion for Induction and Maintenance on Hemodynamics and Postoperative Recovery Study Overview ================= Brief Summary ----------------- To study the Effect of Ciprofol Infusion for Induction and Maintenance of anesthesia on Hemodynamics and Postoperative Recovery in Patients Undergoing Th...
ctgov
Spleen Stiffness Combined With Liver Stiffness Measured by 2D-SWE for the Screening of High-risk Varices in Compensated Advanced Chronic Liver Disease (CHESS2004) Study Overview ================= Brief Summary ----------------- Variceal hemorrhage is the serious complication in patients with compensated advanced chron...
ctgov
Growth Hormone in Children Under 2 Years With Prader-Willi in Hospital of Sabadell Study Overview ================= Brief Summary ----------------- The PWS is a genetic disease with intellectual disabilities associated with multiple manifestations in other body systems. It is characterized by hypothalamic-pituitary ab...
ctgov
Accelerated Dose Schedule of Cytarabine Consolidation Therapy for Older Patients With Acute Myeloid Leukemia (AML) in Complete Remission Study Overview ================= Brief Summary ----------------- This phase 2, open label, non-randomized study will evaluate the safety of administering high dose cytarabine (HiDAC)...
ctgov
The Clinical Application and Popularization of Portable Home Noninvasive Ventilator Study Overview ================= Brief Summary ----------------- The subjects of this study are the chronic obstructive pulmonary disease (COPD) patients with chronic II respiratory failure. The participants will be divided into two gr...
ctgov
Effectiveness of Divalproex Sodium (Depakote) in Treating Children With Temper Outbursts and Severe Mood Swings Study Overview ================= Brief Summary ----------------- The purpose of this study is to determine the effectiveness of divalproex sodium (Depakote) versus placebo in treating children with temper ou...
ctgov
A Study Designed to Determine if the Drugs Albuterol (Salbutamol) and Fluticasone Have an Effect on the Pharmacokinetics of the Investigational Product Technosphere® Insulin Inhalation Powder in Healthy Volunteers Study Overview ================= Brief Summary ----------------- This study will investigate the effects ...
ctgov
Speech Intelligibility in Noise Using the Hearing in Noise Test (HINT) Study Overview ================= Brief Summary ----------------- The main purpose of the study is to estimate speech intelligibility in noise. A Norwegian Hearing in Noise Test (HINT) for children will be implemented, and test results for normal he...
ctgov
Monocentric Prospective Pilot Study Evaluating the Value of Indocyanine Green (ICG, Indocyanine Green) During a Surgical Resection of Cancerous Lesions Peritoneal Colorectal Origin. Study Overview ================= Brief Summary ----------------- Between 30% and 40% of patients with colorectal cancer develop metastati...
ctgov
Efficacy and Safety Study of Sirukumab in Patients With Giant Cell Arteritis Study Overview ================= Brief Summary ----------------- Sirukumab is a fully human anti-interleukin-6 (IL-6) immunoglobulin G1-kappa with a high affinity and specificity for binding to the human IL-6 molecule that may have therapeuti...
ctgov
European Society for Trauma and Emergency Surgery (ESTES) Cohort Study Snapshot Audit 2020 - Acute Appendicitis Study Overview ================= Brief Summary ----------------- Background Acute appendicitis is an extremely common surgical emergency. Traditionally, appendicitis has been managed surgically. Recently, ho...
ctgov
Study Utilizing BIOZEK COVID-19 Antigen Rapid Test. Study Overview ================= Brief Summary ----------------- This is a research study to evaluate the Sensitivity and Specificity of BIOZEK COVID-19 Antigen Rapid Test on samples collected by a healthcare professional versus self-collection; and to perform analys...
ctgov
A Novel Approach to Enhance True Recovery After Stroke Study Overview ================= Brief Summary ----------------- The purpose of this study is to elucidate pathophysiological mechanisms behind gait disturbances during the early recovery phase after hemiparetic stroke to identify targets for new treatment strateg...
ctgov
Cetuximab + Avelumab or Avelumab Alone for Unresectable, Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (SCCAC) Progressed After at Least One Line of Systemic Treatment (CARACAS) Study Overview ================= Brief Summary ----------------- The standard first line treatment in SCCAC is the association ...
ctgov
Interrupted Subdermal Suture Spacing During Linear Wound Closures and the Effect on Wound Cosmesis Study Overview ================= Brief Summary ----------------- This study aims to investigate whether the spacing of the interrupted deep (subdermal) sutures affects surgical wound cosmesis on the trunk and extremities...
ctgov
A Study Comparing Drug Availability Of Methylprednisolone In Liquid Form Versus Methylprednisolone In Tablet Form Study Overview ================= Brief Summary ----------------- A new formulation of methylprednisolone is being developed. A study is needed to determine the drug availability using the new formulation, ...
ctgov
Transthyretin Amyloidosis Outcome Survey (THAOS) Study Overview ================= Brief Summary ----------------- THAOS is a global, multi-center, longitudinal observational survey open to all patients with transthyretin amyloidosis (ATTR), including ATTR-PN (polyneuropathy), ATTR-CM (cardiomyopathy) and wild-type ATT...
ctgov
Alemtuzumab and Low-Dose Cyclosporine in Treating Patients With Severe Aplastic Anemia or Acquired Marrow Failure Study Overview ================= Brief Summary ----------------- RATIONALE: Immunosuppressive therapies, such as alemtuzumab and cyclosporine, may improve bone marrow function and increase blood cell count...
ctgov
Amiloride in Nephrotic Syndrome Study Overview ================= Brief Summary ----------------- The AMILOR study compares treatment of edema in nephrotic syndrome with Amiloride vs. Furosemide. Detailed Description ----------------- The monocenter randomized-controlled AMILOR trial investigates the efficacy of the E...
ctgov
Bryostatin 1 and Cisplatin in Treating Patients With Advanced Recurrent or Residual Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer Study Overview ================= Brief Summary ----------------- Phase II trial to study the effectiveness of combining bryostatin 1 and cisplatin in treating patients wh...
ctgov
I-Smads in Periodontitis Study Overview ================= Brief Summary ----------------- Recently, it has been stated that Smads play an active role in all conditions where transforming growth factor-beta (TGF-β) is involved, including periodontal inflammation. This study aimed to examine the levels of TGF-β and inhi...
ctgov
Genetics of Symptomatology and Treatment Response in Psychotic Major Depression Study Overview ================= Brief Summary ----------------- We hope to learn more about the biology of psychiatric illness with the hope of improving the diagnosis and treatment of such psychiatric conditions as major depression. Det...
ctgov
4 vs 6 Implants in Totally Edentulous Patient in Maxilla With Ti. Cad-cam Framework Study Overview ================= Brief Summary ----------------- The primary objective of the present study is to evaluate the marginal bone level changes occurring in total edentulous patients treated with six or four implants. Second...
ctgov
SBRT Followed by Neoadjuvant Immunochemotherapy in Resectable Stage IB to III Non-small Cell Lung Cancer Study Overview ================= Brief Summary ----------------- The purpose of this study is to find out the effectiveness stereotactic body radiation therapy (SBRT) followed by two cycles of Tislelizumab (PD-1 in...
ctgov
Hemodynamic and Respiratory Variations During Laparoscopic Surgery With and Without Deep Neuromuscular Blockade. Study Overview ================= Brief Summary ----------------- The goal of this study is to investigate the effect of depth of neuromuscular block (NMB) on global and regional (dependent versus nondepende...
ctgov
Timing of Inguinal Hernia Repair in Premature Infants Study Overview ================= Brief Summary ----------------- The purpose of this study is to determine whether early (before NICU discharge) or late (55-60 weeks post-menstrual age) inguinal hernia repair is safer for premature infants who have an inguinal hern...
ctgov
The Effect of Conservative Treatment on Gait Biomechanics in Adolescent Idiopathic Scoliosis Study Overview ================= Brief Summary ----------------- Adolescent idiopathic scoliosis (AIS) is a three-dimensional complex progressive structural deformity of the growing spine. Asymmetric changes in both the anatom...
ctgov
A Case Control Study of Women With Multiple Sexual Partners Study Overview ================= Brief Summary ----------------- Both population based surveys and more focused research studies indicate that increased numbers of sexual partners and partner concurrency contribute to increased risk for acquisition of sexuall...
ctgov
Fasting Study of Metolazone Tablets 10 mg and Zaroloxyn® Tablets 10 mg Study Overview ================= Brief Summary ----------------- The objective of this study was to investigate the bioequivalence of Mylan metolazone 10 mg tablets to Celltech Zaroxolyn® 10 mg tablets following a single, oral 10 mg (1 x 10 mg) dos...
ctgov
A Study Evaluating BSI-201 in Combination With Chemotherapeutic Regimens in Subjects With Advanced Solid Tumors Study Overview ================= Brief Summary ----------------- The purpose of the study is to assess the safety and establish the maximum tolerated dose (MTD) of the combination of BSI-201 with chemotherap...
ctgov
Rocuronium + Sugammadex vs. Succinylcholine + Cisatracurium + Neostigmine/Atropine in Obese Participants (MK-8616-104) Study Overview ================= Brief Summary ----------------- The primary objective of this trial is to compare the preference between two strategies of neuromuscular blocking (NMB) / reversal in a...
ctgov
Can Passive Leg Raise Prevent Spinal Anesthesia-induced Hypotension During Cesarean Section? Study Overview ================= Brief Summary ----------------- All over the world, spinal anesthesia is widely used in cesarean sections due to its superiority over general anesthesia. Due to reasons such as increased sensit...
ctgov
Treatment of Mild to Moderate Peri-implantitis Using an Oscillating Chitosan Device Study Overview ================= Brief Summary ----------------- 34 patients diagnosed with mild to moderate peri-implantitis, defined as 2-4 mm peri-implant bone loss, will be randomized to either test treatment with Labrida BioClean®...
ctgov
Cell Free DNA in Cardiac Sarcoidosis Study Overview ================= Brief Summary ----------------- Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias...
ctgov
Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy Study Overview ================= Brief Summary ----------------- Smoking has been considered the most important risk factor for periodontitis among all lifestyle factors. Fewer studies evaluated longitudinal ...
ctgov
Evaluation of Post-surgical Improvement in OSA Patients After Imaging of Upper Airway Using CBCT and DISE vs DISE Only Study Overview ================= Brief Summary ----------------- CBCT is considered an innovative imaging modality that can view the upper respiratory airway anatomy in a 3D manner. Recent studies tri...
ctgov
Surveillance for Early Liver Injuries Caused by Runzao Zhiyang Capsule. Study Overview ================= Brief Summary ----------------- This is a prospective registry study to surveil early liver injuries caused by Runzao Zhiyang Capsule (RZZY Capsule) through a non-intervention observational way. And attempt to esta...
ctgov
The Effect of Premedication on Postoperative Pain and Anxiety in Breast Cancer Surgery Study Overview ================= Brief Summary ----------------- In this study, it was investigated whether the premedication drug administered before the surgery had an effect on postoperative pain and anxiety scores in female pati...
ctgov
Assessment of Functional Digestive and Genitourinary Outcomes in Patients With Rectal Cancer. Study Overview ================= Brief Summary ----------------- Total mesorectal excision and neoadjuvant radio-chemotherapy have revolutionized the management of rectal cancer allowing an increase in survival (between 55 an...
ctgov