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A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.
|
[
{
"ade": "ischaemic cerebrovascular accident",
"drug": "streptokinase"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.",
"role": "user"
},
{
"content": "Drug: streptokinase, ADE: ischaemic cerebrovascular accident",
"role": "assistant"
}
] |
We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.
|
[
{
"ade": "hepatitis",
"drug": "riluzole"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.",
"role": "user"
},
{
"content": "Drug: riluzole, ADE: hepatitis",
"role": "assistant"
}
] |
In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.
|
[
{
"ade": "decrease in serum Na+",
"drug": "lorcainide"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.",
"role": "user"
},
{
"content": "Drug: lorcainide, ADE: decrease in serum Na+",
"role": "assistant"
}
] |
A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.
|
[
{
"ade": "manic episode",
"drug": "fluoxetine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.",
"role": "user"
},
{
"content": "Drug: fluoxetine, ADE: manic episode",
"role": "assistant"
}
] |
Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.
|
[
{
"ade": "bilateral pulmonary infiltrates",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.",
"role": "user"
},
{
"content": "Drug: methotrexate, ADE: bilateral pulmonary infiltrates",
"role": "assistant"
}
] |
We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.
|
[
{
"ade": "cranial polyneuropathy",
"drug": "vincristine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.",
"role": "user"
},
{
"content": "Drug: vincristine, ADE: cranial polyneuropathy",
"role": "assistant"
}
] |
RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.
|
[
{
"ade": "weight loss",
"drug": "leflunomide"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.",
"role": "user"
},
{
"content": "Drug: leflunomide, ADE: weight loss",
"role": "assistant"
}
] |
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.
|
[
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.",
"role": "user"
},
{
"content": "Drug: heparin, ADE: thrombocytopenia",
"role": "assistant"
}
] |
Renal injury due to anastrozole has not been published in the English literature.
|
[
{
"ade": "Renal injury",
"drug": "anastrozole"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Renal injury due to anastrozole has not been published in the English literature.",
"role": "user"
},
{
"content": "Drug: anastrozole, ADE: Renal injury",
"role": "assistant"
}
] |
Pulmonary toxicity with mefloquine.
|
[
{
"ade": "Pulmonary toxicity",
"drug": "mefloquine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Pulmonary toxicity with mefloquine.",
"role": "user"
},
{
"content": "Drug: mefloquine, ADE: Pulmonary toxicity",
"role": "assistant"
}
] |
A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.
|
[
{
"ade": "acute chest pain",
"drug": "ritodrine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.",
"role": "user"
},
{
"content": "Drug: ritodrine, ADE: acute chest pain",
"role": "assistant"
}
] |
Recurrent hyponatremia associated with citalopram and mirtazapine.
|
[
{
"ade": "Recurrent hyponatremia",
"drug": "mirtazapine"
},
{
"ade": "Recurrent hyponatremia",
"drug": "citalopram"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Recurrent hyponatremia associated with citalopram and mirtazapine.",
"role": "user"
},
{
"content": "Drug: mirtazapine, ADE: Recurrent hyponatremia; Drug: citalopram, ADE: Recurrent hyponatremia",
"role": "assistant"
}
] |
This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.
|
[
{
"ade": "hepatitis",
"drug": "artesunate"
},
{
"ade": "hepatitis",
"drug": "amodiaquine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.",
"role": "user"
},
{
"content": "Drug: artesunate, ADE: hepatitis; Drug: amodiaquine, ADE: hepatitis",
"role": "assistant"
}
] |
This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.
|
[
{
"ade": "acute lung injury",
"drug": "mefloquine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.",
"role": "user"
},
{
"content": "Drug: mefloquine, ADE: acute lung injury",
"role": "assistant"
}
] |
CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.
|
[
{
"ade": "dermatologic and ocular 5-FU toxicities",
"drug": "5-FU"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.",
"role": "user"
},
{
"content": "Drug: 5-FU, ADE: dermatologic and ocular 5-FU toxicities",
"role": "assistant"
}
] |
In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.
|
[
{
"ade": "spasm",
"drug": "ergonovine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.",
"role": "user"
},
{
"content": "Drug: ergonovine, ADE: spasm",
"role": "assistant"
}
] |
A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.
|
[
{
"ade": "postprandial hyperglycemia",
"drug": "betamethasone valerate"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.",
"role": "user"
},
{
"content": "Drug: betamethasone valerate, ADE: postprandial hyperglycemia",
"role": "assistant"
}
] |
One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.
|
[
{
"ade": "ceroid-like pigment",
"drug": "clofazimine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.",
"role": "user"
},
{
"content": "Drug: clofazimine, ADE: ceroid-like pigment",
"role": "assistant"
}
] |
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.
|
[
{
"ade": "Hypersensitivity reactions",
"drug": "cyclosporine"
},
{
"ade": "Hypersensitivity reactions",
"drug": "Cremophor EL"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.",
"role": "user"
},
{
"content": "Drug: cyclosporine, ADE: Hypersensitivity reactions; Drug: Cremophor EL, ADE: Hypersensitivity reactions",
"role": "assistant"
}
] |
A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.
|
[
{
"ade": "generalized tonic-clonic seizure",
"drug": "naloxone"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.",
"role": "user"
},
{
"content": "Drug: naloxone, ADE: generalized tonic-clonic seizure",
"role": "assistant"
}
] |
The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.
|
[
{
"ade": "radiation recall reactions",
"drug": "gemcitabine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.",
"role": "user"
},
{
"content": "Drug: gemcitabine, ADE: radiation recall reactions",
"role": "assistant"
}
] |
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.
|
[
{
"ade": "Intrahepatic cholestasis",
"drug": "glibenclamide"
},
{
"ade": "cutaneous bullae",
"drug": "glibenclamide"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.",
"role": "user"
},
{
"content": "Drug: glibenclamide, ADE: Intrahepatic cholestasis; Drug: glibenclamide, ADE: cutaneous bullae",
"role": "assistant"
}
] |
This concerns 2 male patients who experienced incontinence while taking venlafaxine.
|
[
{
"ade": "incontinence",
"drug": "venlafaxine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: This concerns 2 male patients who experienced incontinence while taking venlafaxine.",
"role": "user"
},
{
"content": "Drug: venlafaxine, ADE: incontinence",
"role": "assistant"
}
] |
Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.
|
[
{
"ade": "Total blindness with a transient tonic pupillary response",
"drug": "quinine sulfate"
},
{
"ade": "denervation supersensitivity",
"drug": "quinine sulfate"
},
{
"ade": "abnormal visual-evoked potentials",
"drug": "quinine sulfate"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.",
"role": "user"
},
{
"content": "Drug: quinine sulfate, ADE: Total blindness with a transient tonic pupillary response; Drug: quinine sulfate, ADE: denervation supersensitivity; Drug: quinine sulfate, ADE: abnormal visual-evoked potentials",
"role": "assistant"
}
] |
Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.
|
[
{
"ade": "Pigmentary disorders",
"drug": "minocycline"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.",
"role": "user"
},
{
"content": "Drug: minocycline, ADE: Pigmentary disorders",
"role": "assistant"
}
] |
Ticlopidine-induced marrow aplasia treated with cyclosporine.
|
[
{
"ade": "marrow aplasia",
"drug": "Ticlopidine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Ticlopidine-induced marrow aplasia treated with cyclosporine.",
"role": "user"
},
{
"content": "Drug: Ticlopidine, ADE: marrow aplasia",
"role": "assistant"
}
] |
Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.
|
[
{
"ade": "hypocalcemic tetany",
"drug": "fleet phospho-soda"
},
{
"ade": "hypocalcemic tetany",
"drug": "alendronate sodium"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.",
"role": "user"
},
{
"content": "Drug: fleet phospho-soda, ADE: hypocalcemic tetany; Drug: alendronate sodium, ADE: hypocalcemic tetany",
"role": "assistant"
}
] |
Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.
|
[
{
"ade": "Cryptococcus neoformans fatal sepsis",
"drug": "alemtuzumab"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.",
"role": "user"
},
{
"content": "Drug: alemtuzumab, ADE: Cryptococcus neoformans fatal sepsis",
"role": "assistant"
}
] |
Cough induced by quinapril with resolution after changing to fosinopril.
|
[
{
"ade": "Cough",
"drug": "quinapril"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Cough induced by quinapril with resolution after changing to fosinopril.",
"role": "user"
},
{
"content": "Drug: quinapril, ADE: Cough",
"role": "assistant"
}
] |
Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.
|
[
{
"ade": "catatonia",
"drug": "disulfiram"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.",
"role": "user"
},
{
"content": "Drug: disulfiram, ADE: catatonia",
"role": "assistant"
}
] |
Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.
|
[
{
"ade": "Fracture of the femoral neck",
"drug": "PSL"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.",
"role": "user"
},
{
"content": "Drug: PSL, ADE: Fracture of the femoral neck",
"role": "assistant"
}
] |
Visual loss after a single small dose of vincristine has never been reported.
|
[
{
"ade": "Visual loss",
"drug": "vincristine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Visual loss after a single small dose of vincristine has never been reported.",
"role": "user"
},
{
"content": "Drug: vincristine, ADE: Visual loss",
"role": "assistant"
}
] |
Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.
|
[
{
"ade": "cranial nerve areflexia",
"drug": "CBZ"
},
{
"ade": "cortical hyperexcitability",
"drug": "CBZ"
},
{
"ade": "profound burst-suppression EEG pattern",
"drug": "CBZ"
},
{
"ade": "reversible encephalopathy",
"drug": "CBZ"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.",
"role": "user"
},
{
"content": "Drug: CBZ, ADE: cranial nerve areflexia; Drug: CBZ, ADE: cortical hyperexcitability; Drug: CBZ, ADE: profound burst-suppression EEG pattern; Drug: CBZ, ADE: reversible encephalopathy",
"role": "assistant"
}
] |
When measured, the serum lithium level had increased 4-fold during acyclovir therapy.
|
[
{
"ade": "serum lithium level had increased",
"drug": "acyclovir"
},
{
"ade": "serum lithium level had increased",
"drug": "lithium"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: When measured, the serum lithium level had increased 4-fold during acyclovir therapy.",
"role": "user"
},
{
"content": "Drug: acyclovir, ADE: serum lithium level had increased; Drug: lithium, ADE: serum lithium level had increased",
"role": "assistant"
}
] |
Ezetimibe-induced acute pancreatitis.
|
[
{
"ade": "acute pancreatitis",
"drug": "Ezetimibe"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Ezetimibe-induced acute pancreatitis.",
"role": "user"
},
{
"content": "Drug: Ezetimibe, ADE: acute pancreatitis",
"role": "assistant"
}
] |
The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.
|
[
{
"ade": "ulcer",
"drug": "ATRA"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.",
"role": "user"
},
{
"content": "Drug: ATRA, ADE: ulcer",
"role": "assistant"
}
] |
Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.
|
[
{
"ade": "pulmonary toxicity",
"drug": "fludarabine"
},
{
"ade": "Multiple pulmonary nodules",
"drug": "fludarabine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.",
"role": "user"
},
{
"content": "Drug: fludarabine, ADE: pulmonary toxicity; Drug: fludarabine, ADE: Multiple pulmonary nodules",
"role": "assistant"
}
] |
Fulminant hepatic failure associated with bicalutamide.
|
[
{
"ade": "Fulminant hepatic failure",
"drug": "bicalutamide"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Fulminant hepatic failure associated with bicalutamide.",
"role": "user"
},
{
"content": "Drug: bicalutamide, ADE: Fulminant hepatic failure",
"role": "assistant"
}
] |
These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.
|
[
{
"ade": "TRAb/TBII without thyroid-stimulating activity",
"drug": "amiodarone"
},
{
"ade": "thyroiditis",
"drug": "amiodarone"
},
{
"ade": "destructive thyroiditis",
"drug": "amiodarone"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.",
"role": "user"
},
{
"content": "Drug: amiodarone, ADE: TRAb/TBII without thyroid-stimulating activity; Drug: amiodarone, ADE: thyroiditis; Drug: amiodarone, ADE: destructive thyroiditis",
"role": "assistant"
}
] |
The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.
|
[
{
"ade": "lethargy",
"drug": "lithium"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.",
"role": "user"
},
{
"content": "Drug: lithium, ADE: lethargy",
"role": "assistant"
}
] |
Spindle coma in benzodiazepine toxicity: case report.
|
[
{
"ade": "Spindle coma",
"drug": "benzodiazepine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Spindle coma in benzodiazepine toxicity: case report.",
"role": "user"
},
{
"content": "Drug: benzodiazepine, ADE: Spindle coma",
"role": "assistant"
}
] |
Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.
|
[
{
"ade": "Sudden cardiac death",
"drug": "clozapine"
},
{
"ade": "hypersensitivity myocarditis",
"drug": "clozapine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.",
"role": "user"
},
{
"content": "Drug: clozapine, ADE: Sudden cardiac death; Drug: clozapine, ADE: hypersensitivity myocarditis",
"role": "assistant"
}
] |
PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.
|
[
{
"ade": "anemia",
"drug": "ribavirin"
},
{
"ade": "anemia",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "ribavirin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.",
"role": "user"
},
{
"content": "Drug: ribavirin, ADE: anemia; Drug: pegylated interferon alpha-2a, ADE: anemia; Drug: pegylated interferon alpha-2a, ADE: progressive malaise; Drug: ribavirin, ADE: progressive malaise",
"role": "assistant"
}
] |
Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.
|
[
{
"ade": "congestive heart failure",
"drug": "recombinant alpha-interferon"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.",
"role": "user"
},
{
"content": "Drug: recombinant alpha-interferon, ADE: congestive heart failure",
"role": "assistant"
}
] |
However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
},
{
"ade": "Stevens-Johnson syndrome",
"drug": "ofloxacin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.",
"role": "user"
},
{
"content": "Drug: ofloxacin, ADE: toxic epidermal necrolysis; Drug: ofloxacin, ADE: Stevens-Johnson syndrome",
"role": "assistant"
}
] |
Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.
|
[
{
"ade": "electrolyte disorders",
"drug": "Foscarnet"
},
{
"ade": "severe hypomagnesemia",
"drug": "Foscarnet"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.",
"role": "user"
},
{
"content": "Drug: Foscarnet, ADE: electrolyte disorders; Drug: Foscarnet, ADE: severe hypomagnesemia",
"role": "assistant"
}
] |
Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.
|
[
{
"ade": "hypotension",
"drug": "valproate"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.",
"role": "user"
},
{
"content": "Drug: valproate, ADE: hypotension",
"role": "assistant"
}
] |
To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.
|
[
{
"ade": "gastric LPD",
"drug": "MTX"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.",
"role": "user"
},
{
"content": "Drug: MTX, ADE: gastric LPD",
"role": "assistant"
}
] |
Ofloxacin: a probable cause of toxic epidermal necrolysis.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "Ofloxacin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Ofloxacin: a probable cause of toxic epidermal necrolysis.",
"role": "user"
},
{
"content": "Drug: Ofloxacin, ADE: toxic epidermal necrolysis",
"role": "assistant"
}
] |
Trimethoprim-sulfamethoxazole-induced aseptic meningitis.
|
[
{
"ade": "aseptic meningitis",
"drug": "Trimethoprim-sulfamethoxazole"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Trimethoprim-sulfamethoxazole-induced aseptic meningitis.",
"role": "user"
},
{
"content": "Drug: Trimethoprim-sulfamethoxazole, ADE: aseptic meningitis",
"role": "assistant"
}
] |
Hepatotoxicity induced by cyproterone acetate: a report of three cases.
|
[
{
"ade": "Hepatotoxicity",
"drug": "cyproterone acetate"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Hepatotoxicity induced by cyproterone acetate: a report of three cases.",
"role": "user"
},
{
"content": "Drug: cyproterone acetate, ADE: Hepatotoxicity",
"role": "assistant"
}
] |
Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.
|
[
{
"ade": "Prolongation of the QT interval",
"drug": "halofantrine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.",
"role": "user"
},
{
"content": "Drug: halofantrine, ADE: Prolongation of the QT interval",
"role": "assistant"
}
] |
We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.
|
[
{
"ade": "skin toxicity",
"drug": "aminoglutethimide"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.",
"role": "user"
},
{
"content": "Drug: aminoglutethimide, ADE: skin toxicity",
"role": "assistant"
}
] |
Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.
|
[
{
"ade": "Acute myocardial ischemia",
"drug": "epinephrine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.",
"role": "user"
},
{
"content": "Drug: epinephrine, ADE: Acute myocardial ischemia",
"role": "assistant"
}
] |
After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.
|
[
{
"ade": "anaphylaxis",
"drug": "cisplatin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.",
"role": "user"
},
{
"content": "Drug: cisplatin, ADE: anaphylaxis",
"role": "assistant"
}
] |
A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.
|
[
{
"ade": "generalized rigidity",
"drug": "olanzapine"
},
{
"ade": "leukocytosis",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "lithium"
},
{
"ade": "leukocytosis",
"drug": "lithium"
},
{
"ade": "increased serum transaminase and creatine kinase",
"drug": "lithium"
},
{
"ade": "increased serum transaminase and creatine kinase",
"drug": "olanzapine"
},
{
"ade": "generalized rigidity",
"drug": "lithium"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",
"role": "user"
},
{
"content": "Drug: olanzapine, ADE: generalized rigidity; Drug: olanzapine, ADE: leukocytosis; Drug: olanzapine, ADE: fever; Drug: lithium, ADE: fever; Drug: lithium, ADE: leukocytosis; Drug: lithium, ADE: increased serum transaminase and creatine kinase; Drug: olanzapine, ADE: increased serum transaminase and creatine kinase; Drug: lithium, ADE: generalized rigidity",
"role": "assistant"
}
] |
A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.
|
[
{
"ade": "exacerbation of a preexisting maladaptive behavior",
"drug": "phenobarbital"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.",
"role": "user"
},
{
"content": "Drug: phenobarbital, ADE: exacerbation of a preexisting maladaptive behavior",
"role": "assistant"
}
] |
Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.
|
[
{
"ade": "Cardiac arrest",
"drug": "esmolol"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.",
"role": "user"
},
{
"content": "Drug: esmolol, ADE: Cardiac arrest",
"role": "assistant"
}
] |
Interference with the cortisol axis by the microtubule antagonist, CPH82.
|
[
{
"ade": "Interference with the cortisol axis",
"drug": "CPH82"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Interference with the cortisol axis by the microtubule antagonist, CPH82.",
"role": "user"
},
{
"content": "Drug: CPH82, ADE: Interference with the cortisol axis",
"role": "assistant"
}
] |
A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.
|
[
{
"ade": "sarcoma",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.",
"role": "user"
},
{
"content": "Drug: cyclophosphamide, ADE: sarcoma",
"role": "assistant"
}
] |
Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.
|
[
{
"ade": "blood levels in the toxic range",
"drug": "phenytoin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.",
"role": "user"
},
{
"content": "Drug: phenytoin, ADE: blood levels in the toxic range",
"role": "assistant"
}
] |
CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.
|
[
{
"ade": "ischemic skin complications",
"drug": "vasopressin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.",
"role": "user"
},
{
"content": "Drug: vasopressin, ADE: ischemic skin complications",
"role": "assistant"
}
] |
Transient global amnesia after clioquinol: five personal observations from outside Japan.
|
[
{
"ade": "Transient global amnesia",
"drug": "clioquinol"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Transient global amnesia after clioquinol: five personal observations from outside Japan.",
"role": "user"
},
{
"content": "Drug: clioquinol, ADE: Transient global amnesia",
"role": "assistant"
}
] |
Withdrawal of Depakote resulted in resolution of the effusion.
|
[
{
"ade": "effusion",
"drug": "Depakote"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Withdrawal of Depakote resulted in resolution of the effusion.",
"role": "user"
},
{
"content": "Drug: Depakote, ADE: effusion",
"role": "assistant"
}
] |
Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.
|
[
{
"ade": "fibrotic lesions",
"drug": "cyclophosphamide"
},
{
"ade": "fibrotic lesions",
"drug": "bleomycin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.",
"role": "user"
},
{
"content": "Drug: cyclophosphamide, ADE: fibrotic lesions; Drug: bleomycin, ADE: fibrotic lesions",
"role": "assistant"
}
] |
We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.
|
[
{
"ade": "hyperkalemia",
"drug": "aliskiren"
},
{
"ade": "acute renal failure",
"drug": "aliskiren"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.",
"role": "user"
},
{
"content": "Drug: aliskiren, ADE: hyperkalemia; Drug: aliskiren, ADE: acute renal failure",
"role": "assistant"
}
] |
We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.
|
[
{
"ade": "hypernatraemia",
"drug": "Kayexalate"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.",
"role": "user"
},
{
"content": "Drug: Kayexalate, ADE: hypernatraemia",
"role": "assistant"
}
] |
The mechanism of RTA induced by FK506 has not yet been clearly elucidated.
|
[
{
"ade": "RTA",
"drug": "FK506"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The mechanism of RTA induced by FK506 has not yet been clearly elucidated.",
"role": "user"
},
{
"content": "Drug: FK506, ADE: RTA",
"role": "assistant"
}
] |
We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.
|
[
{
"ade": "SJS",
"drug": "nevirapine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.",
"role": "user"
},
{
"content": "Drug: nevirapine, ADE: SJS",
"role": "assistant"
}
] |
Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.
|
[
{
"ade": "Osteonecrosis",
"drug": "dexamethasone"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.",
"role": "user"
},
{
"content": "Drug: dexamethasone, ADE: Osteonecrosis",
"role": "assistant"
}
] |
Adenosine-induced ventricular fibrillation.
|
[
{
"ade": "ventricular fibrillation",
"drug": "Adenosine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Adenosine-induced ventricular fibrillation.",
"role": "user"
},
{
"content": "Drug: Adenosine, ADE: ventricular fibrillation",
"role": "assistant"
}
] |
The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.
|
[
{
"ade": "severe thrombocytopoaenia",
"drug": "quinine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.",
"role": "user"
},
{
"content": "Drug: quinine, ADE: severe thrombocytopoaenia",
"role": "assistant"
}
] |
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.
|
[
{
"ade": "demyelinating peripheral neuropathy",
"drug": "cytosine arabinoside"
},
{
"ade": "Horner's syndrome",
"drug": "cytosine arabinoside"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.",
"role": "user"
},
{
"content": "Drug: cytosine arabinoside, ADE: demyelinating peripheral neuropathy; Drug: cytosine arabinoside, ADE: Horner's syndrome",
"role": "assistant"
}
] |
Carbamazepine-induced hyperammonemia.
|
[
{
"ade": "hyperammonemia",
"drug": "Carbamazepine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Carbamazepine-induced hyperammonemia.",
"role": "user"
},
{
"content": "Drug: Carbamazepine, ADE: hyperammonemia",
"role": "assistant"
}
] |
Corneal endothelial deposits associated with rifabutin use.
|
[
{
"ade": "Corneal endothelial deposits",
"drug": "rifabutin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Corneal endothelial deposits associated with rifabutin use.",
"role": "user"
},
{
"content": "Drug: rifabutin, ADE: Corneal endothelial deposits",
"role": "assistant"
}
] |
CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.",
"role": "user"
},
{
"content": "Drug: ofloxacin, ADE: toxic epidermal necrolysis",
"role": "assistant"
}
] |
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.
|
[
{
"ade": "severe hepatotoxicity",
"drug": "benzarone"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.",
"role": "user"
},
{
"content": "Drug: benzarone, ADE: severe hepatotoxicity",
"role": "assistant"
}
] |
The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.
|
[
{
"ade": "hypercortisolism",
"drug": "CPH82"
},
{
"ade": "suppression of the endogeneous production of ACTH and cortisol",
"drug": "CPH82"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.",
"role": "user"
},
{
"content": "Drug: CPH82, ADE: hypercortisolism; Drug: CPH82, ADE: suppression of the endogeneous production of ACTH and cortisol",
"role": "assistant"
}
] |
Severe acidosis from acetazolamide in a diabetic patient.
|
[
{
"ade": "Severe acidosis",
"drug": "acetazolamide"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Severe acidosis from acetazolamide in a diabetic patient.",
"role": "user"
},
{
"content": "Drug: acetazolamide, ADE: Severe acidosis",
"role": "assistant"
}
] |
Rupture of a cerebral aneurysm associated with nifedipine treatment.
|
[
{
"ade": "Rupture of a cerebral aneurysm",
"drug": "nifedipine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Rupture of a cerebral aneurysm associated with nifedipine treatment.",
"role": "user"
},
{
"content": "Drug: nifedipine, ADE: Rupture of a cerebral aneurysm",
"role": "assistant"
}
] |
CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.
|
[
{
"ade": "delay corneal wound healing",
"drug": "colchicine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.",
"role": "user"
},
{
"content": "Drug: colchicine, ADE: delay corneal wound healing",
"role": "assistant"
}
] |
We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.
|
[
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "mizoribin"
},
{
"ade": "SIADH",
"drug": "mizoribin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.",
"role": "user"
},
{
"content": "Drug: mizoribin, ADE: syndrome of inappropriate secretion of antidiuretic hormone; Drug: mizoribin, ADE: SIADH",
"role": "assistant"
}
] |
Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.
|
[
{
"ade": "methanol poisoning",
"drug": "methanol"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.",
"role": "user"
},
{
"content": "Drug: methanol, ADE: methanol poisoning",
"role": "assistant"
}
] |
We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.
|
[
{
"ade": "prolonged QT",
"drug": "methadone"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.",
"role": "user"
},
{
"content": "Drug: methadone, ADE: prolonged QT",
"role": "assistant"
}
] |
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.
|
[
{
"ade": "morbidity",
"drug": "hyperbaric oxygen"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.",
"role": "user"
},
{
"content": "Drug: hyperbaric oxygen, ADE: morbidity",
"role": "assistant"
}
] |
We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.
|
[
{
"ade": "diphasic dyskinesias",
"drug": "levo-dopa"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.",
"role": "user"
},
{
"content": "Drug: levo-dopa, ADE: diphasic dyskinesias",
"role": "assistant"
}
] |
BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.
|
[
{
"ade": "hemolytic-uremic syndrome",
"drug": "gemcitabine"
},
{
"ade": "HUS",
"drug": "Gemcitabine"
},
{
"ade": "HUS",
"drug": "gemcitabine"
},
{
"ade": "renal toxicity",
"drug": "Gemcitabine"
},
{
"ade": "hemolytic-uremic syndrome",
"drug": "Gemcitabine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.",
"role": "user"
},
{
"content": "Drug: gemcitabine, ADE: hemolytic-uremic syndrome; Drug: Gemcitabine, ADE: HUS; Drug: gemcitabine, ADE: HUS; Drug: Gemcitabine, ADE: renal toxicity; Drug: Gemcitabine, ADE: hemolytic-uremic syndrome",
"role": "assistant"
}
] |
A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.
|
[
{
"ade": "bromide intoxication",
"drug": "pyridostigmine bromide"
},
{
"ade": "postoperative psychosis",
"drug": "pyridostigmine bromide"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.",
"role": "user"
},
{
"content": "Drug: pyridostigmine bromide, ADE: bromide intoxication; Drug: pyridostigmine bromide, ADE: postoperative psychosis",
"role": "assistant"
}
] |
Capecitabine-induced headache responding to diltiazem.
|
[
{
"ade": "headache",
"drug": "Capecitabine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Capecitabine-induced headache responding to diltiazem.",
"role": "user"
},
{
"content": "Drug: Capecitabine, ADE: headache",
"role": "assistant"
}
] |
Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).
|
[
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "Treosulfan"
},
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "dihydroxybusulfan"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).",
"role": "user"
},
{
"content": "Drug: Treosulfan, ADE: Acute non-lymphocytic leukemia; Drug: dihydroxybusulfan, ADE: Acute non-lymphocytic leukemia",
"role": "assistant"
}
] |
Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.
|
[
{
"ade": "serotonin syndrome",
"drug": "citalopram"
},
{
"ade": "serotonin syndrome",
"drug": "fentanyl"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.",
"role": "user"
},
{
"content": "Drug: citalopram, ADE: serotonin syndrome; Drug: fentanyl, ADE: serotonin syndrome",
"role": "assistant"
}
] |
The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.
|
[
{
"ade": "hypotension",
"drug": "verapamil"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.",
"role": "user"
},
{
"content": "Drug: verapamil, ADE: hypotension",
"role": "assistant"
}
] |
Acute acoustic nerve palsy associated with vincristine therapy.
|
[
{
"ade": "Acute acoustic nerve palsy",
"drug": "vincristine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Acute acoustic nerve palsy associated with vincristine therapy.",
"role": "user"
},
{
"content": "Drug: vincristine, ADE: Acute acoustic nerve palsy",
"role": "assistant"
}
] |
Disopyramide (Norpace)-induced hypoglycemia.
|
[
{
"ade": "hypoglycemia",
"drug": "Disopyramide"
},
{
"ade": "hypoglycemia",
"drug": "Norpace"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Disopyramide (Norpace)-induced hypoglycemia.",
"role": "user"
},
{
"content": "Drug: Disopyramide, ADE: hypoglycemia; Drug: Norpace, ADE: hypoglycemia",
"role": "assistant"
}
] |
We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.
|
[
{
"ade": "local cutaneous reactions",
"drug": "pegylated interferon alfa-2b"
},
{
"ade": "local cutaneous reactions",
"drug": "ribavirin"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.",
"role": "user"
},
{
"content": "Drug: pegylated interferon alfa-2b, ADE: local cutaneous reactions; Drug: ribavirin, ADE: local cutaneous reactions",
"role": "assistant"
}
] |
Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.
|
[
{
"ade": "multifocal leukoencephalopathy",
"drug": "Capecitabine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.",
"role": "user"
},
{
"content": "Drug: Capecitabine, ADE: multifocal leukoencephalopathy",
"role": "assistant"
}
] |
This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.
|
[
{
"ade": "dysphagia",
"drug": "haloperidol"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.",
"role": "user"
},
{
"content": "Drug: haloperidol, ADE: dysphagia",
"role": "assistant"
}
] |
The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.
|
[
{
"ade": "dystonia",
"drug": "carbamazepine"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.",
"role": "user"
},
{
"content": "Drug: carbamazepine, ADE: dystonia",
"role": "assistant"
}
] |
One patient had severe temporary weakness after an ampicillin sodium challenge.
|
[
{
"ade": "severe temporary weakness",
"drug": "ampicillin sodium"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: One patient had severe temporary weakness after an ampicillin sodium challenge.",
"role": "user"
},
{
"content": "Drug: ampicillin sodium, ADE: severe temporary weakness",
"role": "assistant"
}
] |
Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.
|
[
{
"ade": "hypertrophic obstructive cardiomyopathy",
"drug": "dexamethasone"
}
] |
[
{
"content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.",
"role": "user"
},
{
"content": "Drug: dexamethasone, ADE: hypertrophic obstructive cardiomyopathy",
"role": "assistant"
}
] |
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