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The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin.	[ { "ade": "interstitial granulomatous dermatitis", "drug": "darifenacin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin.", "role": "user" }, { "content": "Drug: darifenacin, ADE: interstitial granulomatous dermatitis", ...
When DSCG was withdrawn, urticaria vanished and the child remained symptom-free.	[ { "ade": "urticaria", "drug": "DSCG" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: When DSCG was withdrawn, urticaria vanished and the child remained symptom-free.", "role": "user" }, { "content": "Drug: DSCG, ADE: urticaria", "role": "assistant" } ]
Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.	[ { "ade": "Retinopathy", "drug": "ribavirin" }, { "ade": "Retinopathy", "drug": "pegylated interferon" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.", "role": "user" }, { "content": "Drug: ribavirin, ADE: Retinopathy; Drug: pegylated interfero...
Torsade de pointes during loading with amiodarone.	[ { "ade": "Torsade de pointes", "drug": "amiodarone" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Torsade de pointes during loading with amiodarone.", "role": "user" }, { "content": "Drug: amiodarone, ADE: Torsade de pointes", "role": "assistant" } ]
An amiodarone optic neuropathy has been described.	[ { "ade": "optic neuropathy", "drug": "amiodarone" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: An amiodarone optic neuropathy has been described.", "role": "user" }, { "content": "Drug: amiodarone, ADE: optic neuropathy", "role": "assistant" } ]
Prior to surgery, levodopa induced dyskinesia had improved (< or = 50%) under treatment with amantadine (400 mg/day, po) in all three patients.	[ { "ade": "dyskinesia", "drug": "levodopa" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Prior to surgery, levodopa induced dyskinesia had improved (< or = 50%) under treatment with amantadine (400 mg/day, po) in all three patients.", "role": "user" }, { "content": "Drug: levodopa, ADE:...
METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.	[ { "ade": "vomiting", "drug": "Viokase" }, { "ade": "vomiting", "drug": "Pancrease MT 16" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with pla...
It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.	[ { "ade": "hypersensitivity syndrome", "drug": "dapsone" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.", "role": "user" }, { "content": "Drug: dapsone, ADE: hypersensitivity syndrome", ...
The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.	[ { "ade": "electrophysiologic effect", "drug": "procainamide" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.", "rol...
Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.	[ { "ade": "Acute intravascular hemolysis", "drug": "glyburide" }, { "ade": "Acute intravascular hemolysis", "drug": "chlorpropamide" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.", "role": "user" }, { "content": "D...
Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.	[ { "ade": "DRESS", "drug": "Linezolid" }, { "ade": "drug rash with eosinophilia and systemic symptoms", "drug": "Linezolid" }, { "ade": "acute interstitial nephritis", "drug": "Linezolid" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.", "role": "user" }, { "content": "Drug: Linezolid, ADE: DRESS; Drug: Linezol...
Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.	[ { "ade": "nephrotoxicity", "drug": "cisplatinum" }, { "ade": "cardiotoxicity", "drug": "adriamycin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.", "role": "user" }, { "content": "Drug: cisplatinum, ...
Triazolam-induced nocturnal bingeing with amnesia.	[ { "ade": "amnesia", "drug": "Triazolam" }, { "ade": "nocturnal bingeing", "drug": "Triazolam" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Triazolam-induced nocturnal bingeing with amnesia.", "role": "user" }, { "content": "Drug: Triazolam, ADE: amnesia; Drug: Triazolam, ADE: nocturnal bingeing", "role": "assistant" } ]
When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.	[ { "ade": "vague symptoms", "drug": "desmopressin" }, { "ade": "hyponatremia", "drug": "desmopressin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.", "role": "user" }, { "content": "Drug: desmopressin, ADE: vague sympt...
A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.	[ { "ade": "massive proteinuria", "drug": "methicillin" }, { "ade": "acute nephritic syndrome", "drug": "methicillin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.", "role": "user" }, { "content": "Drug: methicil...
Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.	[ { "ade": "Withdrawal emergent syndrome", "drug": "haloperidol" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.", "role": "user" }, { "content": "Drug: haloperidol, ADE: Withdrawal emergent syndrome", "role": "assistan...
Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.	[ { "ade": "aplastic anemia", "drug": "gold" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.", "role": "user" }, { "content": "Drug: gold, ADE: aplastic anemia", "role": "assistant" ...
Aliskiren-associated acute renal failure with hyperkalemia.	[ { "ade": "acute renal failure", "drug": "Aliskiren" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Aliskiren-associated acute renal failure with hyperkalemia.", "role": "user" }, { "content": "Drug: Aliskiren, ADE: acute renal failure", "role": "assistant" } ]
Lower extremity arterial insufficiency after long-term methysergide maleate therapy.	[ { "ade": "arterial insufficiency", "drug": "methysergide maleate" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Lower extremity arterial insufficiency after long-term methysergide maleate therapy.", "role": "user" }, { "content": "Drug: methysergide maleate, ADE: arterial insufficiency", "role": "assistan...
Hepatotoxicity related to itraconazole: report of three cases.	[ { "ade": "Hepatotoxicity", "drug": "itraconazole" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Hepatotoxicity related to itraconazole: report of three cases.", "role": "user" }, { "content": "Drug: itraconazole, ADE: Hepatotoxicity", "role": "assistant" } ]
We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.	[ { "ade": "mild hypotension", "drug": "pilocarpine" }, { "ade": "muscarinic symptoms", "drug": "pilocarpine" }, { "ade": "bradycardia", "drug": "pilocarpine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.", "role": "user" }, {...
We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.	[ { "ade": "eosinophilic cystitis", "drug": "dimethyl sulfoxide" }, { "ade": "eosinophilic cystitis", "drug": "DMSO" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.", "role": "user" },...
OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.	[ { "ade": "neutropenia", "drug": "vancomycin" }, { "ade": "neutropenia", "drug": "teicoplanin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.", "role": "user" }, { "content": "Drug: vancomycin, ADE: neutropeni...
Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.	[ { "ade": "cerebrospinal fluid eosinophilia", "drug": "vancomycin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.", "role": "user" }, { "content": "Drug: vancomycin, ADE: cerebrospinal fluid eosinophilia", "role": ...
We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.	[ { "ade": "stroke", "drug": "PPA" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.", "role": "user" }, { "content": "Drug: PPA, ADE: stroke"...
We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.	[ { "ade": "ulcerative proctitis", "drug": "ibuprofen" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.", "role": "user" }, { "content": "Drug: ibuprofen, ADE: ulcerative proctiti...
CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.	[ { "ade": "worsening of chronic aphthous ulcers", "drug": "tacrolimus" }, { "ade": "worsening of chronic aphthous ulcers", "drug": "sirolimus" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.", "role...
Linear IgA bullous dermatosis occurring after carbamazepine.	[ { "ade": "Linear IgA bullous dermatosis", "drug": "carbamazepine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Linear IgA bullous dermatosis occurring after carbamazepine.", "role": "user" }, { "content": "Drug: carbamazepine, ADE: Linear IgA bullous dermatosis", "role": "assistant" } ]
We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.	[ { "ade": "panhypogammaglobulinaemia", "drug": "prednisolone" }, { "ade": "panhypogammaglobulinaemia", "drug": "cyclophosphamide" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.", "role": "user" }, { "content": "Drug: prednisolone, A...
The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.	[ { "ade": "no motile sperm", "drug": "carbamazepine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.", "role": "user" }, { "content": "Drug: carbamazepine, ADE: no motile spe...
The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.	[ { "ade": "exacerbating OCS", "drug": "quetiapine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.", "role": "us...
This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.	[ { "ade": "refractory coronary vasospasm", "drug": "cocaine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coron...
Generalized argyria after habitual use of AgNO3.	[ { "ade": "Generalized argyria", "drug": "AgNO3" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Generalized argyria after habitual use of AgNO3.", "role": "user" }, { "content": "Drug: AgNO3, ADE: Generalized argyria", "role": "assistant" } ]
Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour.	[ { "ade": "significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons", "drug": "HAL" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour.", "role...
Central nervous system toxicity associated with meperidine use in hepatic disease.	[ { "ade": "Central nervous system toxicity", "drug": "meperidine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Central nervous system toxicity associated with meperidine use in hepatic disease.", "role": "user" }, { "content": "Drug: meperidine, ADE: Central nervous system toxicity", "role": "assistant" ...
CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.	[ { "ade": "side-effect on retinal function", "drug": "rifabutin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.", "role": "user" }, { "content": "Drug: rifabutin, ADE: side-effect o...
The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.	[ { "ade": "multiple myeloma", "drug": "DILANTIN" }, { "ade": "multiple myeloma", "drug": "diphenylhydantoin" }, { "ade": "IgG lambda-type monoclonal gammopathy", "drug": "diphenylhydantoin" }, { "ade": "IgG lambda-type monoclonal gammopathy", "drug": "DILANTIN" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.", "role": "user" }, {...
L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.	[ { "ade": "pancreatitis", "drug": "L-asparaginase" }, { "ade": "lethal complication", "drug": "L-asparaginase" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.", "role": "user" }, { "content": "Drug: L-asparaginase, ADE: pancreatitis; Drug: L-...
We believe the temporal association of the abnormal liver enzymes in this patient, in the absence of other offending agents, argues strongly in favor of 6-TG as a cause of liver enzyme abnormalities.	[ { "ade": "abnormal liver enzymes", "drug": "6-TG" }, { "ade": "liver enzyme abnormalities", "drug": "6-TG" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We believe the temporal association of the abnormal liver enzymes in this patient, in the absence of other offending agents, argues strongly in favor of 6-TG as a cause of liver enzyme abnormalities.", "rol...
BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.	[ { "ade": "teratogenic", "drug": "Accutane" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.", "role": "user" }, { "content": "Drug: Accutane, ADE: teratogenic", "role": "assistant"...