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773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 11:36:46 | **Background of this problem :**
I want to use machine learning on a set of data.
The scale mentioned above is the IDP-hydropathy scale of amino acids (AA), or simply put : their affinity with water (see pic above)
I have an alignment of proteins, and at each position on this alignment, i captured the different amin... | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 13:32:14 | I might be misunderstanding your question. A variable that captures the change of hydropathy from the old AA to the new AA could simply be the difference of their hydropathy values, right? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 13:51:47 | Yes, but i have the impression i would miss some information
Like :
** Case 1 : **
oldAA score = -2
newAA score = 3
Then difference = 5
**Case 2 :**
oldAA score = 1
newAA score = 6
difference = 5
the difference is the same in both case
But in case 1 the newAA changes the direction of hydropathy, it goes from hydroph... | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 13:52:14 | Ah, OK, so you want to capture sign changes | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 13:52:32 | Yes exactly | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 13:52:59 | and maybe the "neutral" (close to 0) ? but thats maybe too much to ask xD | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 13:54:11 | This is a crude example: the difference if there's no sign change, but double the difference if there's a sign change? Something like that? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 13:56:06 | Actually yes maybe that could work, i was actually trying to work my mind around this
I don't want to involve too much arbitrary values like saying x2 when opposite sign | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 13:56:20 | but i guess thats the easiest way to do it | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 13:56:49 | Yeah, I don't like it either | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 13:57:04 | How important is the flip, as compared to the absolute difference? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 13:57:15 | Also what do you mean by this? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 13:57:56 | This is hard to tell, i supposed it depends on where the amino acid is located | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 13:59:01 | the protein is located in the membrane so part of it is hydrophobic, while some are hydrophilic | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 13:59:48 | an hydrophobic amino acid in the external part of the membrane might have more impact | 0 | 1 | 740,938,819,125,248,100 | idioticbaka1824 | 9340 | idioticbaka1824 | false | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:00:19 | neutral is close to 0, it doesnt have much relation with water | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:00:42 | On second thought, taking all of this into account might make the model a bit too complicated :sadcat: | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:01:05 | Like maybe stick with a simplistic idea first and see how the results are, and refine it as you go on | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:03:45 | i tried, i'm at the stage where i try to improve the model 😄
And the hydropathy of amino acid is known to be important for the structure of the protein, especially for proteins located in the membrane, that's why i want to make use of this feature | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:04:25 | Aha I see that's cool | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:04:57 | Similar to this problem, i used the volume | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:05:01 | but the volume was different | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:06:22 | Okay so let's say the old and new values are x and y. We want a function that increases with their difference, but is weighted higher if they are of different signs, ie in quadrants 2 and 4. How about a 2d sigmoid kind of thing to accomplish this? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:08:04 | i'm afraid you're mentioning things out of my scope of knowledge haha
Let me google that one second
(thanks for the help btw! ) | 0 | 1 | 376,014,466,585,722,900 | Arthek | 5238 | Arthek | false | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:10:18 | ok, so i should create a function that transform my data through a sigmoid function ? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:11:25 | |x-y|.(1 - 1/(1+e^-x)). (1/(1+e^-y)) | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:11:34 | Oh heck one sec | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:11:55 | Try plotting that | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:17:14 | Plotting ? you have a specific tool for that? with which data?
Sorry im a bit confused | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:25:15 | Sorry, gimme a couple minutes | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:43:41 | im a big noob in maths so bare with me, i just copied your formula but i have no idea what it does lol
It seems something might be wrong though
I don't know if it's what you suggested me to do, but i did that : | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:43:51 | Capture_decran_2022-02-19_a_20.42.28.png | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:51:22 | Yo I am so sorry that was a fool's errand I had no idea what I was doing | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:51:26 | please forget about it | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 14:52:16 | Ok np 😄 | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:58:49 | Okay, so what I'm suggesting, after more experimentation, is that for the difference, instead of using |x-y|, you could use |x-y|\*((1-1/(1+exp(-2x)))\*(1/(1+exp(-2y)))+(1-1/(1+exp(-2y)))\*(1/(1+exp(-2x)))) | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:59:16 | The '2' inside the exp represents how strongly you want the flips to matter | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 14:59:23 | you could make it more or less | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:06:07 | ok thx im gonna try plotting that 😄 | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:06:26 | https://c3d.libretexts.org/CalcPlot3D/index.html | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:06:55 | basically it takes the absolute difference and boosts its importance if the two numbers have different signs | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:07:22 | which would help if paying attention to hydrophobic to hydrophilic changes | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:13:38 | Alright! thanks! | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:14:13 | How did you come up with that formula ? 😄 | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:15:13 | uhh... trial and error, let's say 😅 | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 914,057,068,565,114,900 | S0n⁷ | 02/19/2022 15:27:59 | sorry for interrupt | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 914,057,068,565,114,900 | S0n⁷ | 02/19/2022 15:28:15 | but when can i ask my quesiton? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:28:32 | ? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:29:08 | About my current problem ? go ahead 😄
Or do you mean a new question for your own math problem ? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 914,057,068,565,114,900 | S0n⁷ | 02/19/2022 15:29:19 | sec ome | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 914,057,068,565,114,900 | S0n⁷ | 02/19/2022 15:29:30 | one* | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:29:54 | check the "available" channels section to ask a new question | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:31:34 | it looks beautiful but i got no idea how that works haha
I recognize some logistic function ( i just googled them)
Im gonna test in the machine learning model later after diner, see if it improves it, thanks a lot for your help, will keep you in touch | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:32:43 | I think the two features can basically be built with the same idea, only difference is y=old AA or y=mean of AA, yeah? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:32:57 | right | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:33:13 | but there's also the standard deviation giving a good info on the spread of data | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:33:34 | the more spread = the less conserved = the less impact of a mutation | 0 | 1 | 376,014,466,585,722,900 | Arthek | 5238 | Arthek | false | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:34:06 | wait, wouldn't more spread mean the mutation is more impactful? | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:34:15 | no | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:34:17 | like it can do more stuf.. idk.. | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:34:40 | no it's like the evolution kept things really specific for important things | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:35:11 | oh i think i see what you mean | 0 | 1 | 376,014,466,585,722,900 | Arthek | 5238 | Arthek | false | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:35:14 | if one amino acid is hydrophobic and among all related proteins it is also hydrophobic, that means this amino acid has a specific role and must remain hydrophobic | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:35:29 | makes sense | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:36:02 | so basically, if the variance is more, the "difference" is less? | 0 | 1 | 740,938,819,125,248,100 | idioticbaka1824 | 9340 | idioticbaka1824 | false | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:36:53 | thats why if the mean is hydrophobic++ or hydrophilic++ and has a really low standard deviation, there's a high chance that a mutation changing the hydro score will have a bad impact so we want to capture that | 0 | 1 | 376,014,466,585,722,900 | Arthek | 5238 | Arthek | false | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:37:02 | yes 🙂 | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:38:13 | this is some big brain logic here | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:41:12 | hm okay then. Let x=newAA, y=mean of old AA, s=stdev or variance of the old AAs. Then you could just use the formula from earlier, but throw in an additional factor of 3*(1-1/(1+exp(-2s) )) | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:41:26 | the 3 and 2 are just parameters you can adjust to your liking | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 376,014,466,585,722,900 | Arthek | 02/19/2022 15:43:39 | Sounds good yes :) thank you i will test that | 0 | 1 | null | null | null | null | null | |||||
773 | help-10 | d0ef48004630404188fa0844059ae384 | 740,938,819,125,248,100 | idioticbaka1824 | 02/19/2022 15:43:59 | cool then! i hope it works | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 573,905,759,134,548,000 | Nonna | 02/19/2022 19:56:33 | How many complex roots does a polynomial of degree 2.5 (or more generally a polynomial of non-integer degree) have? (Sorry for the bad english) | 1 | 0 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 19:57:53 | A polynomial has non-negative integer degree by definition. | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 573,905,759,134,548,000 | Nonna | 02/19/2022 19:58:07 | Oh | 1 | 0 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 573,905,759,134,548,000 | Nonna | 02/19/2022 19:58:11 | I didn't knew it | 1 | 0 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 19:58:24 | $z^{2.5} = a$ | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 510,789,298,321,096,700 | TeXit | 02/19/2022 19:58:31 | **Shuri2060** | 321445119171756033.png | 0 | 1 | null | null | null | null | null | ||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 19:58:32 | Are you referring to this? | 0 | 1 | 740,938,819,125,248,100 | idioticbaka1824 | 9340 | idioticbaka1824 | false | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 19:58:37 | Or something more general? | 0 | 1 | 376,014,466,585,722,900 | Arthek | 5238 | Arthek | false | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 573,905,759,134,548,000 | Nonna | 02/19/2022 19:58:49 | Yeah, something like that | 1 | 0 | 376,014,466,585,722,900 | Arthek | 5238 | Arthek | false | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 19:58:54 | Well this should have 5 roots | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 19:59:33 | I will ignore the modulus | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 20:00:05 | $$e^{i \frac{a}{b}\theta} = e^{i(\phi + 2n\pi)}$$ | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 510,789,298,321,096,700 | TeXit | 02/19/2022 20:00:27 | **Shuri2060** | 321445119171756033.png | 0 | 1 | null | null | null | null | null | ||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 20:00:37 | We perhaps have something like this? | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 20:00:50 | You exponentiate both sides by b/a | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 20:01:16 | This should result in `a` roots mod 2pi | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 20:01:38 | If you don't have a rational power... I'm not so sure. | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 321,445,119,171,756,000 | Shuri2060 | 02/19/2022 20:01:46 | It feels like you have infinite roots. | 0 | 1 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 573,905,759,134,548,000 | Nonna | 02/19/2022 20:02:22 | Thanks a lot, I really mean it | 1 | 0 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 573,905,759,134,548,000 | Nonna | 02/19/2022 20:02:23 | exactly what I needed | 1 | 0 | null | null | null | null | null | |||||
774 | help-10 | ae20229f065f4ec3bcf220ee65f310b6 | 573,905,759,134,548,000 | Nonna | 02/19/2022 20:02:41 | .close | 1 | 0 | 510,789,298,321,096,700 | TeXit | 0796 | TeXit | true | |||||
775 | help-10 | ae7b0ed6a95d412abd80453d61c57bdb | 469,258,940,455,321,600 | H1tle7 | 02/19/2022 20:19:27 | Hey @MetalNinja27 Can you help me with my homework plz | 1 | 0 | null | null | null | null | null | |||||
775 | help-10 | ae7b0ed6a95d412abd80453d61c57bdb | 200,013,547,491,688,450 | a disappointing son | 02/19/2022 20:20:53 | :flonshed: | 0 | 1 | null | null | null | null | null | |||||
775 | help-10 | ae7b0ed6a95d412abd80453d61c57bdb | 186,109,587,366,215,680 | Omegabet_ | 02/19/2022 20:22:05 | #❓how-to-get-help | 0 | 1 | null | null | null | null | null | |||||
775 | help-10 | ae7b0ed6a95d412abd80453d61c57bdb | 929,724,109,011,681,300 | RDT | 02/19/2022 20:23:49 | #❓how-to-get-help | 0 | 1 | null | null | null | null | null | |||||
775 | help-10 | ae7b0ed6a95d412abd80453d61c57bdb | 229,743,249,877,762,050 | MetalNinja27 | 02/19/2022 20:36:39 | uh | 0 | 1 | null | null | null | null | null | |||||
775 | help-10 | ae7b0ed6a95d412abd80453d61c57bdb | 229,743,249,877,762,050 | MetalNinja27 | 02/19/2022 20:36:40 | .close | 0 | 1 | null | null | null | null | null | |||||
776 | help-10 | f10d9bff875c417c8c372e50de3576d5 | 216,996,711,413,973,000 | momo | 02/19/2022 20:48:37 | can someone help me out with this problem | 1 | 0 | null | null | null | null | null |
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