Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q8PE48 | 2.4.1.18 | ACT_SITE 403; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 456; /note="Proton donor"; /evidence="ECO:0000250" | MTNRWDPGVTRALAEARHGDAFAVLGAHPSTNGRLLRTYHPGAEHVTAVLADGREVPLEAGPEPGLFAGELPAEGRYRLRIGWPGGTQDTADPYAFGPLLSDFDLHLISEGHHLQLADALGANAVEVDGVRGTRFAVWAPNASRVAVVGDFNSWDARRHPMRLRHQAGVWELFVPDVGPGAHYKYQLRGPHGHELPAKADPVARRAELAPGTASIVADPTPHQWSDDGWMATRARRQAHDAPMSIYEIHAGSWLREEGLDLDWDGLADRLIPYVADMGFTHVELMPVTEHPFGGSWGYQPLGLFAPTARFGSPDGFARFV... | 73 |
A0A1S4C5F9 | 1.11.1.7 | ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLKTAFFSKLSKKSRKFQFAMDFTRKLSFLVFLLCILISLQNQDDIDTNNNFSSHDDKYCSLSDDESQYIFDIDSFPPLPMFATTSHVERKLQQQTGARESLKYDYYHQTCPQAERIIRSSVRDLFKKRPQIAPALLRLAFHDCFVEGCDASVLLDPAEGFHSEKESPPNESLKGFDVIDIIKSELEEACPGVVSCADAVVLAARESVILTGGPFYPLKTGRRDSVASFGEIATFELPSPQDDLSKMIESFSSKGFDEREAVSLLGAHSTGVIHCKFFINRLYNFSGTNSSDPTMNSEFVSLLRSKCNTNQASLMSPASK... | 14 |
A7SQ72 | 2.1.1.37 | ACT_SITE 413; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | GVLVWSKLKGYDWWPGRVVTYMEAGRPPPGPGNHWVKWFGDNKFSQVTYDTVLPFAEFKSNFLVTKMKGLYKKAVLDALEVLKKKLLSKDTETPAEPDEPLSEEEKCDAMVNWALTGFQPQGASGFAPTLEETIFLPPVSSDSDEEEADQTVNGSESTKGRFGKPVKEPNLVQDIKGTCMVFKLIMYVFMLDICLACGDCKVYAQHPLFEGGLCKECKQSFLECTYLFDEDGYQASGGMYCTICGDGQEVFMCDNEGCFRSYCGPCLEMLAGRGTVREIASREKWICYMCSGKGDRLIHRRKDWQSKLHELFLSDREKEY... | 47 |
A0A1D5TSA1 | 1.11.1.7 | ACT_SITE 121; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVSLSFTSSLQLGAQAIRTRRDESGWSTFYPPWIFVKASELKKMGLSSSLVPMASALLLLCCFTAWNAAAAAASGGGGDGLRLNYYSESCPRAEEIVKEQVRRLYEEHGNTAVSWLRALFHDCTVKSCDASLLLETDAATGLVSEQASPRSFGMRNFKYVGAIKSALERECPGTVSCADVLALAARDGAAMLGGPAAIPMRTGRRDATESRYGEVERYVPNHNDTVSAVLSRFAAMGLDAEAVVALLGAHSVGRVHCNNLVARLYPAVDGGMEPAYGAYLRGRCPTADAREDTRDVAYARNDRATPMVLDNMYHKNLLKG... | 14 |
G7IVH6 | 3.1.1.11 | ACT_SITE 417; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSFFKSYGKVDEHDQMMLEAKRKTRKRITIISLSSIIFIGVVIAAVLGVVNSKNDDDNNNNASQNSVTNSMKAVCDVTLYKDSCYNSLSSIVGSGKEVQPEELFKLSINVALTHVSKAVEYFNEHGVFKKLIENSRTNEALKNCRVLLDLAIDHLNNTLTASRENSSLHQVFDDLQTWLSAAGTYQQTCIEGFEDTKEQLKTSVTSYLKNSTEYTSNSLAIITYINKAINTLNLRRLMSLPYENETPKWFHSKDRKLLSTKDLRSKADIVVAKDGSGKYKTISDALKHVPNKSKKRTLIYVKKGIYYENVRVEKTKWNVM... | 125 |
A0A8V1ACC2 | 3.2.1.35 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MPRGALLPIHPSLAVVPDCPLITLGTSCREARWPHVAVTSGAGSPPRLQLRIKALRSSAQRCVVPERVRSPRSTMAPGWLCWALLLLLPAPVRAAGPGPVLVNRPFVTVWNIPSEPCAQQYNVTLPLGVFDVVANTEEAFIGQDIALFYSSHLGLFPYYTAQGQPVDGGLPQNASLVAHLQRARRDIGAALPSTRYDGLAIVDWEQWRPLWARDWSSMDIYREKSEELVRRQHPLWPHSHVEEVAQQQFQKAARAFMEQTLRLGEAMRPAGYWGFYGFPDCYNNNFSDPLYNGSCPVVEQQRNQELGWLWNCSRALYPSI... | 166 |
D8RGZ6 | 6.3.4.4 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 103; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125" | MQASGLAGLGSSSQPRRGRRNHQLRLLGSARGRVLCNAQAVQQRQQQSDVAKAKIADPYSSLGQVCAVLGTQWGDEGKGKLVDILARHYDIVARCQGGDNAGHTIYDDKGDKFALHLVPSGILQRDTVCMVGNGVVVHLPKLFEEIKQLEAKGISCEGRIRVSDRAHLLFDFHRTVDALREAELAGSMIGTTKRGVGPCYASKATRNGIRVGDLLDMSTFRDKLEILLEDAAARFDKFTYDKSMLEEEVVRYRDFAEKLGPYIADTVYLINQAYHDKKKILVEGGQATMLDVDFGTYPFVTSSNPSVGGVCTGLGIAPKR... | 253 |
A0A1U8ITT1 | 3.1.1.11 | ACT_SITE 222; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDYCCVLVMVIMTLFASCFGVGLSKTNEIYVKNFISWDDMKVDGHKIRLNTSTVYHNQSRVIVVDKNGGGDSITVQEAVNMVPEYNKQRVKIYILPGIYREKVVVPRFKPYISFVGNEGQMANTIISWHDKASDRNSNGGSLGTYRSASVTVGSDYFCATDITFENTVIGAPGEPGRQAVALRIYGDKAMFYKVKIVGGQDTLLDETGSHYFYHSVIQGSVDFISGKSRSLYQECLIQSTAKKIGAIAAHHRDLPDDNTGFSFVSCIITGSGKVYLGRAWGNYSRTIYSNCYFDNVIIPAGWSDWNDPLRHKTVEFGEFQ... | 125 |
A0A3Q7ENF6 | 3.1.1.11 | ACT_SITE 387; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"; ACT_SITE 837; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"; ACT_SITE 1406; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGITKFLFILILLPFYQVLCQYEYETFHPYQRSPTLDPHAMIIQACSNIQNQALCLSHIQSNLDDPVHRDPNSILKAAIQNSLNQAKLTIQSITKFSTLSASSRDQMAIEDCQELLDFSVTELAWSLGEMRKIRAGSKNVHYEGNLKAWLSAALSNQDTCLEGFEGTDRHLEHFIKGSLTQVTQLISNVLTLYVQLHSLPFKPPRNDNITYENQKYPQWMTKGDKDLLVSNPNGMHVDAVVSLDGSGRYRSIAQAINEAPSYSNRRYVIYVKRGIYHENIDLKKKKTNIMLVGDGIGATVITGNRNFMQGWTTFRTATVA... | 125 |
A0A251TJQ4 | 1.11.1.7 | ACT_SITE 46; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSMPMASSGFYENTCPKVEAIVQKIIAEKISLAPSLAAPLLRMHFHDCFVRGCDGSVLIDSTKNNQAEKDGFPNLSLRGFQIIDAAKTVVEAACPGVVSCADILALVARDAMYQIKGPYWPVPLGRRDGRVSIASESLTDLPSPFDNITRLKEHFTSKGLSVKDLVVLSGGHTIGTSHCLGVAVRLYNFTGKGDTDPSLDSDYVPYLKSKCKPTDTTTLIEMDPGSFRTFDENYYTNVLKRRGLFVSDAALLNDYETSAYVKLQAQSHGSTFLKDFQESMVKMGQIGVLTGSAGEIRQYCNAIN | 14 |
B7QHP3 | 3.1.3.16 | ACT_SITE 312; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MATPPEGLVAECVHQNDSNSLKSTPEEEEQANRFKEEANEYFKKQEFNTAIDLYSKAIELDPYKAVYYGNRSFAYLKTECFGYALSDASKAIELDRSYVKGYYRRAAAHMSLGKFKLALKDFEAVTKARPNDKDACAKYNECNKIVRRIAFEKAIAVDDLKKSVADSIDIEAMCIEDDYTGPELKEGKVTVEFMKQLMETFKAGKKLHRKYAYKARIPPSFIFFKGSSLPSLVDIEVPSDSKFTVCGDIHGQFFDLMNIFELNGLPSESNPYLFNGDFVDRGSFSVECIFTLLAGFCFLFKITCVLDLIRNHESQTMNQM... | 144 |
Q60DX8 | 3.2.1.21 | ACT_SITE 207; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"; ACT_SITE 421; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0" | MAVSSSTSTCSSFSLLLLLLLLAAAPWRSGEAAAAAARALNFTRQDFPGEFVFGAGTSAYQYEGATDEDGRSPSIWDTFTHAGKMPDKSTGDMGAGGYHKYKEDVKLMSDTSLEAYRFSISWSRLIPRGRGPVNPKGLEYYNSLIDELVERGIEIHVTLYHLDFPQILEDEYHGWLSPRVIDDFTAYADVCFREFGDRVRHWTTMDEPNVLSIAAYDSGAFPPCRCSPPFGANCTAGNSTVEPYVVAHNSILAHASVTRLYRDKYQATQEGFVGMNIYSFWNYPFSSSSADIAATQRALDFMVGWILDPLVYGDYPEIMK... | 161 |
Q4A3V2 | 3.2.1.14 | ACT_SITE 148; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MGRTTGTSVGHQHHVAAFVVVALVALVRFVASQGECSESTACPDNTMCCSQYNYCGTGDAYCGEGCKNGPCNAGGTPPAPEPPTSGSGWSSFFTEEVFDGWFPSRNADFYTFERFKAAASAYPTFGNEGSVDDQKREIAAFFGNVNQESGGLKFVRETNPTEIYCDTTNTQYPCAAGKSYYGRGPIQLSWNYNYGACGAALNLPLLATPELVETDADVAFKTALWFWMANQCHQAIIGPPPSFGKTIRIINGAKECGLVNDERVTNRVTYYTNFCNSLGVDPGTDLRC | 158 |
G1NXY9 | 3.2.1.35 | ACT_SITE 141; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MWAGLSPAIILALALALAVARAKELKPTATPIFTGRPFVVAWDVPTQDCGPRLKVPLDLEEKAFDVQASPNEGFVDQNITIFYRERLGLYPYFDPEAKKPVHGGVPQNDSVLRAHLDMLQERVEHYIRRQEPAGLAVIDWEDWRPVWVRNWQDKDVYRQLSRQLVASRHPDWPPDRVSKQAQYEFEFGAREFMLRTLRSAKRFRPQHLWGFYLFPDCYNHDYVQNWATYTGRCPDVEVSRNDQLAWLWAESTALFPSVYLEEALASTAHGRNFVSFRVQEALRVARTHHASHALPVYVFARPTYSRSLKGLSQMDLISTI... | 166 |
C5X6Y9 | 4.1.1.17 | ACT_SITE 360; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MVGSSPVQAVLAAPGVRDRKVLAFKSDAHKGNKQDVASGLVHSILASTSPPQRSAFYVLDLAKVVDLFRAWRRALPDARPCYAVKCNPDPALLGALAALGAGFDCASRAEIEAVLALGVQPRDIVYANPCKPEAHLEYAAEVGVNLTTYDSEEEVAKVRRCHPACELLLRLKGPDGGGVRVDLGTKYGAHADEVVPLLRAAQRAGVGVAGVSFHVGSGASILAVYSGAIQAARAAFDAAAALGMPPMRVLDIGGGFVSGPTFDDAAAVINDALAQHFGDLPCVEVIGEPGRYFAETAFTLAARVIGKRTRGEVREYWIDD... | 195 |
P9WG33 | 2.2.1.2 | ACT_SITE 143; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000250" | MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVGVTTNPSIFQKALSEGHTYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDSDGVDGRVSIEVDPRLAHETEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAEGISVNVTLIFSVQRYREVMDAYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRLDRIGSRQALELRGQAGVANARLAYATYREVFEDSDRYRSLKVDGARVQRPLWASTGVKNPDYSDTLYVTELVAPHTVNTMPEKTIDAVADHGVIQGDTVTGT... | 52 |
A0A0K9NNF0 | 3.1.3.48 | ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 16; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MSNTEQNVNVYVWDMDETLVLLKSLLEGSFAKVYNGSKDLKRGMEIGKQWENSILQLCDDLFHYNHIEEYNMPFLEYLREHDDGRDLSDYDFSKDNFGFSHDNSFQRKLAYRFRDISQIYSKGLKSVLDEEKIKLWEDLYDATDIYTDRWLSSAKDFLKQLSCKAKDFGSQDTFSDSASNFNDINCQTINVLVTNGSLIPSLAKCLLFRLDDPISYENVYSSWEVGKLQCFSWIKEKYGGPSVRFCAIGDGSEECVAAEKMRWPFVSIDIDPKGTHRFPGLQTKTLRFYMDVIYGEQPKHENDKDNNLPSCVIFNVMGKS... | 149 |
O77328 | 2.7.11.1 | ACT_SITE 1506; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MNEHIKSFKNDNVHYTKKNVIRNYDDHNNIKANSHLKLQSKEYTTHNDEKQRWITSNNTNNNIQTHANVKCDDKSVENKTTTLINKDINEITNISKQDKNYTKYNCLNFNKSDVMRDYVRYSKKEDSSSNNMNGNNNMNGNNNMNGNNNMNGNNNMNGNNNMNGNNNMNGNNNMNDNNNMNGNNIMNGNNIMNGNNNINRNNIMNGNNIMNGNNNINRNNIMNRNNITNNHIIHHISNKTSLIENNKKKEENIFPSANLYKKEMNVKGSSDTFDLLYKRKIDKDDNLSKKKKRPNYLFNKDGEHFVNKENVQNNIIDDDD... | 99 |
K7MBQ9 | 5.1.3.15 | ACT_SITE 183; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 287; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MSTEKEKTSAPSSSSSSSSSSPSVELCKGVNGLEKILLRESRGSSTEVYLYGGHVTSWKNDHGEELLFLSNKAIFKTPKAIRGGIPLCFPQFGGLGTLDQHGFARNRFWAIDDDPPPFPTNTLSKAFVDLILKPSEEDTKIWPHSFEFRLRIALGPGGDLMLTSRIRNTNSEGKPFSFTFAYHTYFSVSDISEVRVEGLETLDYLDNLQNKERFTEQGDALTFESEVDKIYLSTPTKIAIIDHEKKRTFVVRKDGLPDAVVWNPWDKKAKALADFGDDEYKHMLCVEAAAIEKPITLKPGEEWKGRLELSAVPSSYCSGQ... | 210 |
Q5B349 | 1.1.1.37 | ACT_SITE 178; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MVKIALLGAAGQIGTPLSLLCKASDLFAEISLYDIVHVPGIATDLMHIDTRARVTGHLPDDSGLKKALTGADIVVVTAGIARKPGMTRDAQTNASIIRDIFAEIAATCPNAVSCVVTNPVNSTLPVAAETLKKAGVFEPTRLFGITTLDVVRASTFAAHALDSNSDPKAFKVPVIGGHSGATILPLYSQAEPPVNLDKETLAAVIHRVQFGGDEIVKSKQGAGSATTCMAYAGFRFVKAIVAAMNGESVTEEAYVYLPGIAGGQEIAQELGVDYFALKVTLGRTGANQVLPIGEISENESTLLKVAINDLKANIVTGVSF... | 5 |
A0A8V0Z0Z6 | 3.2.1.23 | ACT_SITE 181; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 261; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MLRLLLPLAGLAELLRAANIPQRTFGIDYDCNCFVKDGHPFRYISGSIHYSRVPRYYWKDRLLKMKMAGLNAIQTYVPWNYHEPQMGVYDFSGDRDLEYFLQLASETGLLVILRAGPYICAEWDMGGLPAWLLEKESIVLRSSDSDYLTAVEKWMGVLLPKMKPHLYHNGGPIIMVQVENEYGSYFACDYDYLRSLLKIFRQHLGDEVVLFTTDGASQFHLKCGALQGLYATVDFAPGGNVTAAFLAQRSSEPTGPLVNSEFYTGWLDHWGHRHIVVPSETIAKTLNEILARGANVNLYMFIGGTNFAYWNGANMPYMSQ... | 163 |
Q9SMY7 | 3.1.1.11 | ACT_SITE 340; /note="Proton donor; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 361; /note="Nucleophile; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040" | MSCLKYFLILLMLGLCVSSEENFQYDYLKVPASEFVSSINTIVVVIRQVSSILSQFADFSGDRRLQNAVSDCLDLLDFSSEELTWSASASENPKGKGNGTGDVGSDTRTWLSAALSNQATCMEGFDGTSGLVKSLVAGSLDQLYSMLRELLPLVQPEQKPKAVSKPGPIAKGPKAPPGRKLRDTDEDESLQFPDWVRPDDRKLLESNGRTYDVSVALDGTGNFTKIMDAIKKAPDYSSTRFVIYIKKGLYLENVEIKKKKWNIVMLGDGIDVTVISGNRSFIDGWTTFRSATFAVSGRGFLARDITFQNTAGPEKHQAVA... | 125 |
G7JS35 | 3.1.1.11 | ACT_SITE 433; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFQDFDLINERRKSEKRAQMRKRIIIGVISSVVFVGLIGCAFFVATTKYNPFGGGGGGSHPEDSSTANGSKHVAHSEKVVKLVCSSADYKEKCEGPLNKAVEKDPKLQHPKDLLKVYLKTVEDEVNKAFNKTNSFKFNTKEEKAAFEDCKEMIQYAKDDLATSIDQLSEADMKKLASKTPDLNSWLSAVITFQETCVDGFPDGKLKTDLQKLFQGSREFVSNSLAIVSQVSTFLSSLQTMGAPRMLLSDNSPVASMDSEGIPSWIQSEERRVLKAADIRPKPNVVVAKDGSGNFRTISAALAAIPPNFLGRYVIYVKEG... | 125 |
A0A8I6G914 | 2.7.10.1 | ACT_SITE 909; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MDSLAGLVLCGVSLLLYGLVEGAMDLILINSLPLVSDAETSLTCIASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGCEAQKWGPDCNRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGSEGCKSYVFCLPDPYGCSCATGWRGLQCNEACPYGHYGPDCKLRCHCTNEEMCDRFQGCLCSQGWQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICK... | 97 |
A9UUK8 | 2.2.1.1 | ACT_SITE 423; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MADPKRVKMMQDDLSKLCVNTIRVLAADTVQKASSGHPGAPMGCAPMAHALWSAVMNYNPSNPRWFNRDRFVLSNGHACALQYCMLHLTGYDMTMDDLKSFRQVESRTPGHPENHLTEGIEVSTGPLGQGLSNAVGLALAEKHLAATFNRPGFDMVDHHTFVICGDGCLQEGVSAEASSLAGHLRLGKLIVLYDDNQITIDGETELSFGEDVLKRYEAYGWHVSSVSKGDSTDPAELLKAIEDAKAVTDKPSIIKVRTVIGIGSQNQGTEKVHGSPLGDEDLAQVKKLYGFDPEASFVVSDEVYEFYKKRADLGREAAAN... | 51 |
A0A022R2G6 | 5.3.1.8 | ACT_SITE 298; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MGGAGGVPGIVRLRCSVMRYEWGKLGEESGVARLYAKNNGDEIDGGGPYAEFWMGTHESGPSYAMEASGGSEISLKDWIQQNPSVLGDKVLHKWGPHLPFLFKVLSVAKALSIQAHPDKDLAAILHRQHPGVYKDDNHKPEMALALTEFEALCGFIGLEEFKNVLRHVPEIVEVVGTSYADQILHISDKEGEMKLKEVLRSLFTKLMSASKAVITEVVVKLITRLNIKHEARQLTEKEELVLMLEKQYPGDVGVIASFLLNYVKLKSGEALYIGANEPHAYIHGECVECMATSDNVVRAGLTPKTLDVQTLCSMLTYKQG... | 214 |
Q69J29 | 3.1.1.11 | ACT_SITE 234; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAATGVLVVVVALVFAVTVAGGGGAGVGGDGGFITWEDLSMPAGAARSSTWDDTAGGGGGKRSGGGGGGEQRTTIVVSPDGTGHSRTVQGAVDMVPAGNTRRVKIVVRPGVYREKVTVPITKPFVSLIGMGTGHTVITWHSRASDVGASGHQVGTFYSASVAVEADYFCASHITFENSAAAAAPGAVGQQAVALRLSGDKTVLYKCRILGTQDTLFDNIGRHYLYNCDIQGSIDFIFGNARSLYQGCTLHAVATSYGAIAASQRSSPSEESGFSFVGCRLTGSGMLYLGRAWGKYSRVVYSYCDLSGIIVPQGWSDWGDQ... | 125 |
A0A8I6XXX3 | 1.11.1.7 | ACT_SITE 107; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATKLAALVVLVAFLAGPAACEGVTICFNGWLRLPLLNTLLCRGSGIPRKPAPPPSGLGLVYGYYNYNSSTSRSYCPGAEGIVRGAVEKAVAANRGIGAGLIRLFFHDCFVRGCDASVLLTTTNSKNSDTEREGPPNKNSLRGFEVIEEAKAAIEAVCPNTVSCADIVAFAARDASYILSDRRINIAMPGGRYDGRESFATETDQLPGPFSNTAQLQESFTAKGLNSEAMIALSGAHTIGSARCMFFSSRFPEMDPAFAAKLKGQCNGNDNTNVDQDYMTPDVLDKQYYQNVIDNKVLFTSDAVLSSTETIKEVKENANM... | 14 |
H2M125 | 3.1.4.11 | ACT_SITE 328; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 375; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MTKCYEFNWQKHLPEFMQEGASFDRFDEDPYLFEPNCLVRVDEFGFFITWKNEGKEGQVLECSLINSIRVGAVPKDPKILSSFESIGKTEADLEGCIICICSGADLVNLSFMFMVADNPETARKWIEGLRSVIHNFKANNVCPMTCLKKHWMKMCFLTNINGKIPVRGITRTFASGKTEKGIFQALKDLGLPSGKNDEIEPSDFTFDMFYALTQKICPRTDIEELFKKINGNKTDYLTVDHLVSFLNENQRDPRLNEILFPFYDPKRAMQIIEKYERDEELKKKGRMSSDGFCRYLMSDENAPVFLDRLELYQEMDQPLA... | 153 |
P13706 | 1.1.1.8 | ACT_SITE 206; /note="Proton acceptor"; /evidence="ECO:0000250" | MADKVNVCIVGSGNWGSAIAKIVGANAAALPEFEERVTMFVYEELIDGKKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAAKNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGGGIDLISHIITRHLKIPCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVDVFYPGSKLSTFFESCGVADLITTCYGGRNRRVSEAFVTSGKTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLEDKF... | 7 |
Q9S785 | 1.1.1.8 | ACT_SITE 278; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P21695" | MMDHLVETNSVPSRLVEERLDEIRRVMGKADDDPLRIVGVGAGAWGSVFIAMLQENYGKFRGKVSVRIWRRGGRAIDKATAEHLFEVINSREELLRRLIRRCAYLKYVEARLGDRVLYADEILKDGFCLNMIETPLCPLKVVTNLQEAVWDADIVINGLPSTETFQVFNEISKYWKERVNAPVIISLAKGVEAEFEPHPRIVTPTQMIHRATGIPLENILYLGGPNIASEVYNKEYANARICGSEKWRKPLGKFLRQSHFIVWDNSDLITHEVMGGLKNVYAIGAGMVATLTKESATSKSVYFAHCTSEMIFITHLLAKE... | 7 |
T1G8U7 | 4.1.1.17 | ACT_SITE 363; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MKDIGSSASSSSSPMINETMYANFDNDLSEVVCDKIKITETEDNFDAFYVADMGDIVRKHKIWKALLPRVQPFYAVKCNDNAEVLKVLAKLGTGFDCASKGEIQKVLDLGVSSDRIIYANPCKQSSHIKYAARHHVEFMTFDNETELLKVKEYHPNAKLVVRILPPASDKCQCELGMKFGCHLKHVAKLLQLAKKLELDVIGVSFHVGSGCYDSNAYLSAVKSAHEVFSVAHSEGFQFNLLDIGGGFPGQPNAKLSFNEIVDVLKPALDALFPEESGVQIIAEPGRFFVASAFTLAVSVISSRQVPSEIQGGEPSYMHYV... | 195 |
A5I788 | 4.1.1.50 | ACT_SITE 63; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000255|HAMAP-Rule:MF_00464"; ACT_SITE 68; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00464"; ACT_SITE 83; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000255|HAMAP... | MKYSGYHLVIDLFGCNFDQLENTEYIIEMLKKLARALDTKIVAKAFHKFHPQGFSGALIISESHITIHTWPEDAYIGIDIFTCSKCFDPRKIVAYLKENLIFKKVEIKEILRGKID | 196 |
Q8L2I5 | 1.5.5.2 | ACT_SITE 131; /evidence="ECO:0000250|UniProtKB:Q72IB8"; ACT_SITE 181; /evidence="ECO:0000250|UniProtKB:Q72IB8" | MVITRDFFLFLSKSGFLNKMARNWGSRIAAGKIIGGNDFNSSIPTIRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGLDIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQAYLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYTAIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVFLPYGEDWYGYFMRRLAERPSNIAFAFKGMTKK | 30 |
Q9NAH6 | 2.7.11.1 | ACT_SITE 210; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MADVFEFELEGHESQASPQRHAYHYDNCTEIMEDDHMYSNVADGQISAPPPSSSYMEDPMMESIQLCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTTGSDNGQIFAMKVLQKATIVRNQKDTAHTKAERNILEAVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLSEIVVSLEHLHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQKTHTFCGTIEYMAPEILMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRLTLPAYLSNEARDLIKKLL... | 99 |
A0A3B3H3Y8 | 2.7.10.1 | ACT_SITE 771; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MTMDYFLLLCVSLLSVVLAVEETLMDTRWATTELAWTSHPETGWEEVSGYDDAMNPIRTYQVCNVQQLNQNNWLRSDFIPRKDVLRVYVEIKFTVRDCNSIPNIPGSCKETFNLFYYESDSDSATATSPFWMENPYVKVDTIAPDESFSMLDSGRVNTKVRSFGPLSKAGFYLAFQDLGACMSLISVRVFYKKCSTTIANFAVFPETATGAEATSLVIAPGTCVPNALEVSVPLKLYCNGDGEWMVPVGACTCSAGFEPAGKETQCQACGSGTFKSKQGESPCLPCPTNSRATSGAASLCSCRNGYYRSDTDSADSPCTT... | 97 |
H9G4A1 | 2.7.11.1 | ACT_SITE 321; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 338; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MDYREEIMSQIVPGQFDDADPLDSGPEQDIKTTQEEKVLVKIEQWRSIEEADVEEFYESSEGEEDDWDWDDDAGKVTKRNPLSGGRNPQANKHISNSSAAKMSTPTDKALRKFENKINLDKLHFADSVINRVTEKSRQREADSYRVKDKSDRATVEQVLDPRTRMILFKMLTRGVISEINGCISTGKEANVYHASTANGESRAIKIYKTSILMFKDRDKYVSGEFRFRHGYCKGNPRKMVRTWAEKEMRNLTRLHTAQIPCPEPIMLRSHVLLMSFIGKNDTPAPLLKNAQLSESKARELYLQVIQYMRRMYQDAKLVHA... | 99 |
A0A1L8EZS5 | 2.7.11.25 | ACT_SITE 302; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1" | MEPLRCLLSLSGSSRTTSGATRAGGNDASVLPVPLASEEDEEQEERGTTPTRQDFLEEEEDGGGSGDVAGFIAEQPSSSSSSANALYWTAVFDYEASAEDELTLRLGDLVQVLSKDSSVSGDEGWWTGKIQDRVGIFPSNYVTRTQSFSGKLQGKRVEELPCCPASALQLEEIDFSELVLEEIIGIGGFGKVYRAIWGLEEVAVKAARHDLDEDISQTIENVKQEAKLFAMLDHPNIIALRGVCLKEPNLCLIMEFARGGSLNRVLSGKKIPPDILVNWAVQIARGMNYLHNEAIVPVIHRDLKSSNVLILQMVENGDLS... | 105 |
Q926Y9 | 1.1.1.205 | ACT_SITE 308; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 404; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1" | MWETKFAKEGLTFDDVLLVPAKSDVLPNDVDLSVEMAPSLKLNVPIWSAGMDTITEAKMAIAIARQGGIGVVHKNMSIEQQAEEIEKVKRSESGVIIDPFYLTPDHQVFAAEHLMGKYRISGVPIVNNEKERKLVGILTNRDLRFISDYSTVIKDVMTKENLVTAPVGTTLKQAEQILQKHRIEKLPLVDEAGILKGLITIKDIEKVIEFPNSAKDKHGRLLAAAAVGITNDTFVRVEKLIEAGVDAIVIDTAHGHSAGVINKISEIRQTFKDVVIVAGNVATAEGARALFEVGVDIVKVGIGPGSICTTRVVAGVGVPQ... | 3 |
O43108 | 7.2.2.10 | ACT_SITE 353; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250" | MDSHTSTEGVPLSETNNRSHATPSAQYCQMTVEETCSKLQTNPETGLTSSQEAMHRRDIHGSNEFAQEEEDSLIKKFFEQFSENPLLLLLIGAAAVSFFMGNHDDAISITLAILIVTTVGFVQEYRSEKSLEALNKLVPPEAHLIRAGNSQTVLASTLVPGDLVEFSVGDRIPADCRIVKAVHLSIDESNLTGETTPVTKDTNPVTGTPPIGLADRTNTAYMGTLVRDGNGTGIVVGTGSHTAFGAVYDMVSEISTPKTPLQASMDNLGKDLSLVSFGVIGVICLIGMFQGRDWLEMFTIGVSLAVAAIPEGLPIIVTVT... | 258 |
Q4Q4U1 | 1.8.1.4 | ACT_SITE 455; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MFRRNIAHLASYDVTVIGGGPGGYVAAIKAAQLGLKTACIEKRGALGGTCLNVGCIPSKALLHATHLYHDAHANFAQYGLRGGENVTMDVSAMQAQKGKGVKALTGGVEYLFKKNKVTYYKGEGSFVNPNTIKVKGLDGKEETLESKKTIVATGSEPTELPFLPFDEKVVMSSTGALDLDHVPKKMIVVGGGVIGLELGSVWARLGAEVTVVEFASRCAATTDADVSKALTDALVKHEKMKIMTNTKVVSGTNNGSSVTIEVEDKDGKHQTLEADALLCSVGRRPHTTGLNAEAINLQMERGFICINDHFETNVPNVYAI... | 36 |
C6TED1 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEARSLYSLVFLVLALAIVNTVHGQGTRVGFYSSACPLAESIVKSTVTTHVNSDSTLAAGLLRMHFHDCFVQGCDASVLIAGSGTERTAFANLGLRGFEVIDDAKTQLEATCPGVVSCADILALAARDSVVHSGGLSYQVPTGRRDGRISQASDVSNLPAPFDSVEVQTQKFTAKGLNTQDLVTLVGAHTIGTTACQFFSNRLYNFTANGPDPSIDPSFLPQLQSLCPQNGDGSKRVALDTGSQTKFDLSYYSNLRNSRGILQSDQALWSDASTKTTVQRYLGLIKGLLGLTFNVEFGKSMIKMGNIELKTGTDGEIRKI... | 14 |
A2ERB6 | 2.3.2.26 | ACT_SITE 1829; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MDEGFSVDFGSFDENTCKTGPLTHETIHDADKTLNQLIHNAISTKSINWMTLHAIQDILERNPYDKGSVTNTIREVHEYLQNQKDTLSKILFCMLMFYTCTDDNDIFKQYESISKDVISDILSNSNPSLLESVLYVLCLKGIQLSNDIMEYTNQLLMKQNIDFLGSERIVENLVKLGIRPPQSYYMNKKSLVERIISHNGLTSLSILPIEIIKDNVDIFIDYSKAYDIIMYCFQHNIKAIEYFVAFIDENNMNDEIWNILKNQSVHLPFKLNKYAIQKSKESLSDAEYCFKFMSYALDYETIKEIIKNSQNKDLLKDINL... | 65 |
Q75CA4 | 6.5.1.1 | ACT_SITE 322; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135" | MVIYPWLKNTTELTIALPKKPIIHANMDVLGSPRGGTPTGEHEINAQDGSPINFSPSPDFCWLCDELFIKLEEVALKKKDLGKPRKVRNLEITSNFVSLWRKTVGNDIYPALVLSLPYNDRRSYRVKDVTLVKALCKHMKLPRNSETERRLLHWKQNAPRGVKLSTFCVEELQKRRREPVVPKRMSIDEVNGMLDKLEHESNVGKWSYISLAESPAFNYCLEHMSYVELRFFFDIVLKVPIVSGLESLLLSCWHPDAESYFKVVSDLRIVAHTLYDPNERLEKNDLSVRIGYAFAPHMAQRVKIPYEKVSTKLGNDFYVE... | 254 |
A0A1S4ARU0 | 3.4.19.12 | ACT_SITE 93; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 96; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 294; /evidence="ECO:0000256|PIRSR:PIRSR013503-1" | MQDQEGHVADAGKETLTSVQTSEIEDWTKYKDDDIMQQQSSIQAEQAVKTQFVGDKEPLSSLEAEYHLGNSILLEKIKVLSEQYAALRRTRGDGNCFFRSFMFGYLEHILESQDQSEVHRIKASIEECKKTLQSLGYAEFTFEDFFALFLEQLDNVLQGSKDSISHEELLRRSRDPSISDYVVMFFRFVTSGEIRKRSEFFEPFILGLTNASVEQFCKSSVEPMGEESDHVQIIALSDALGVPIRVVYLDRSSCENNSINVNHHDFVPTSDGMGNSGVSKTTNPSITLLYRPGHYDILYPK | 175 |
G5EEN4 | 2.7.11.1 | ACT_SITE 240; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSSSNLAGNTNTTTTSSAASAAAAHSAANASTITSEYSTTQTTTGTFNTDTLSSIGSTSTLHGSQPSQPPPPPPPQVSSPIAAAAAASAALVAQLNPADRWPTEPSAYKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTA... | 99 |
Q7ZVW7 | 2.7.11.1 | ACT_SITE 329; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038189-1" | MSDVTPNTPVRKLRYSALRALADLLDPQDTWRSIMADISRPCGEPRYTQMHMRRFEACVLQGKSPTMELLFDWGTSDCTVGDLVEILIRHQLFAAVTVLLPDHSVCHAHTGSVWCEEAAPASAVCLQACEITQTVEDNSNKPQKISKPVEDDSNKPVQEQELFVEPDSSSGAQESSWDSSQGFHTFSLHELTAMTQHWDERPLSDGGCRLGSGGFGVVFRGRMGDKHVAVKKLNPLDGSSYEDLRKQFNQEIQTLRSLSHENVLRVLGCSCSGPPLCVVFELMVNGSLLERLACAEHTPALTWRNRCWITVGAARGLSYL... | 99 |
G7IIS3 | 3.1.1.11 | ACT_SITE 475; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFEDFDLVSERRKANAKQHLKKKILIGVTSVVLIACVIAAVTFVIVKRSGPDHNNNDKKPVQNAPPEPERVDKYSRLVTMLCSHSEYKEKCVTTLKEALKKDPKLKEPKGLLMVFMLVAKNEINNAFNKTANLKFASKEEKGAYEDCKQLFEDAKEEMGFSITEVGQLDISKLASKEAELNNWLSAVISYQDTCSDGFPEGELKKKMEMIFAESRQLLSNSLAVVSQVSQIVNAFQGGLSGFKLPWGKSDAHAPAPDADTDAVADDDEDLADAPDGAPDADQPIFEAPIGAPGAAPIGAPRVDAPPSWAAPAVDLPGST... | 125 |
A7S5I8 | 3.2.1.143 | ACT_SITE 238; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 256; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 257; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | RDKWDKDHVRMPCSTNNLYPMENSKKVQNRWELIESALLAPIKSSHDLQDAILKYNARYSSRWNFEALHCYFNEYLDSSDAQEFFDHTLPAMVRLTLQIPSVCTVAIPLMKRQKNHSITISQHQAACLLANAFFCTFPRRNSHKHSEYSNFPDINFNRLFQGGKGGTSTVKCEKLQSVLHYFRCVTQCTPTGTLTFHRQALQSEDLPKWERSSENFSRLHVSTKGNIEDDGTGFLQVDFANKYIGGGVIGEGCVQEEIRFLICPEMILSRLFCERLDSNECVFIIGAQRFSNYTGYAHTFKWAGHHDDKSIRDSWGRRYS... | 159 |
A0A8V0ZSG8 | 3.5.1.98 | ACT_SITE 714; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MRSGGFPGAELTGCSQPQGTALTLSAALVMFSPSSAVTPCTSPRVPQAVPMDLRIGQRVVKPGSDTALLALKHTQQLQHQLFLASLHQQQVEQLAHQHVRVTMETSHREAEPGQQEQELRQILNKDKSKRSAVASTVVKQKLAEVILKKQQAAALERTSNPNPPAMPYRSLEPLDPEGPSPPVLSTFLSPVPSTSLDPPEHFPLRKTASEPNLKVRCKPRKCLDRRKNPLTRKESAPPSLKRRPPETIDSSPSSSSTPVSGCSSPNDSLPAEHGALPAASSMAHEGDADRRPLSGLAHRVPVLNGPVLTGTHSPMFIPAG... | 184 |
A8XC38 | 3.2.1.17 | ACT_SITE 28; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR608597-1"; ACT_SITE 39; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR608597-1" | MFVKSLLLLSVAIAYVSADCLHCICMRESQCKPIGCHMDVGSLSCGYYQIKIGYYEDCGQPGKKSGESTEAAWKRCADDLSCSTTCVENYYNRYKSQCNGLGMGACQIMARNHNGGPRGCHNGGTQAYWNGVHACCGCS | 160 |
P23561 | 2.7.11.25 | ACT_SITE 579; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEQTQTAEGTDLLIGDEKTNDLPFVQLFLEEIGCTQYLDSFIQCNLVTEEEIKYLDKDILIALGVNKIGDRLKILRKSKSFQRDKRIEQVNRLKNLMEKVSSLSTATLSMNSELIPEKHCVIFILNDGSAKKVNVNGCFNADSIKKRLIRRLPHELLATNSNGEVTKMVQDYDVFVLDYTKNVLHLLYDVELVTICHANDRVEKNRLIFVSKDQTPSDKAISTSKKLYLRTLSALSQVGPSSSNLLAQNKGISHNNAEGKLRIDNTEKDRIRQIFNQRPPSEFISTNLAGYFPHTDMKRLQKTMRESFRHSARLSIAQRR... | 105 |
P52694 | 1.2.1.12 | ACT_SITE 151; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P0A9B2" | MTIKIGINGFGRIGRMVFRAAIANFKDIEVVAINDLLEPDYLAYMLKYDSVHGRFDGEVSVDGNTLVVNGKKIRLTAVKDPAELKWGEVGADVVVESTGIFLTKEGAQKHIDAGAKKVIMSAPSKDDTPMFVYGVNHGTYKGEAIISNASCTTNCLAPVAKVLNDKWGIKRGLMTTVHAATATQKTVDGPSNKDWRGGRGILENIIPSSTGAAKAVGVVIPQLNKKLTGMSFRVPTSDVSVVDLTVELEKAASYDEICAEMKAQSQGALKGVLGYTEDKVVATDFRGDARTSIFDAEAGIALDGTFIKVVSWYDNEWGYS... | 22 |
A9UU68 | 2.3.2.26 | ACT_SITE 548; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | GWEIRATDQGRLYYVNHNDRTTSWQPPGIDEFGELPEGWEIRRDARGRVYYVDHNSRSTTWQRPNADLLSQRRQFAAGQTTLAQAAQQHGQRSLGFSSSVEQQVEPHDDRGPLPPGWEQRQTPQGRAYYVYHPARHTQWEDPRLQDAMASVETMPLPAGWEIRSTTDGRRYFVDHNTRSTTFRDPRLDLAKRGPDKSIPQYHREFKHKVWCLHKHYCPQVQGQFKMPIRRSSLFQDSFDCIMSEHPDETGFRRLFITFQGEQGLDYGGVAREWFFLISHEMLDPMYCLFEYATANNYQLQINPNSHVNPEHLQYFRFVGR... | 65 |
A0A8V0XR66 | 3.1.1.4 | ACT_SITE 74; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 119; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | GEPGSPSKVFGARVWKGALGKSHSLHTRGIIELAGAISCGTGRSPLAYIGYGCYCGLGGQGWPKDKTDWCCHRHDCCYDKAEREGCSPKAQRYQWVCEQNAVQCDNLTDQCEKMVCLCDQEAAKCWGTAPYNPQFILWPDFLCGQTHPTCHFKYEGSK | 130 |
A7SNP3 | 3.5.1.23 | ACT_SITE 153; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR017632-1" | MAKALVARLTTVLIVCGITHTFTIPHRNVLDSFKDTTQKFSDDSCVDNAYPPTDDPKVETEVINLDLAPQDRYNDLVAKKGKEMHDLLNYINNFTSFIDHGKLFGIIDKDLGPLTETLPSPYKEEIQGLSTASGLAQGEVLLYNIFYEVFTVCTSIVAEDKKGHIFHARNLDFGLFLGWDNKTDTWALSEILRPLVINLDYKRGGKTVYQTVTFAGYIGVITGIKPGVLTVTLNERFNINGGFIGILEWILGQRTSQWTSFLTRNVLESAKSYKEAYDMLTNTEVLAPVYYILGGTKSGQGAVITRSRTKTLDVQGLLLA... | 182 |
A8HP06 | 1.3.5.1 | ACT_SITE 328; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MPVLAKLLGGASKASSLQQLAGLGQRAALAATQQAGFASQSYPVIDHQYDAIVVGAGGAGLRAAVGLSELGFNTACITKLFPTRSHTVAAQGGINAALGNMTEDDWRWHAYDTIKGSDWLGDQDAIHYMCREAPKAVIELENYGLPFSRTEDGKIYQRAFGGQSLDFGKGGQAYRCACAADRTGHAMLHTLYGQAMKHDIQFYVEYFALDLIMDSDGVCRGVMALCMEDGTLHRFQAHQTVLATGGYGRAYFSATSAHTCTGDGNAMAARAGIPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGILRNSEGERFMERYAP... | 28 |
A7S279 | 3.1.4.11 | ACT_SITE 332; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 377; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MAEPKLPWEVYVPLKLQSGTLLSRWDEASFLNKEPNNKLRINTTYVDKCGFFLAWRSQDDKEGSSIEISNISEVRLGVLPKDQKVRESLQRTGADPLEERGFTVVYNTNLVDCNYLHLFASTSRVAKEWVEGLRPLLHNVRLDNCSVLTQLHKQYVKAGLHKDALGKISVKSICKALYAGKFESLVLDALQALGLPCSKNDKITPEDFTFEHFYQLYLKVCPRLEIMELCVEWGGGRAPILTATQLVNFMNKEQRDPRLNEILFPFCDNEKALSLIWKYEKQMDMLQRDRICVNGLTRYLLSEDNLLIMPGRLNLSDDMN... | 153 |
A0A7M7RGP6 | 3.2.2.27 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MLGQAKISAFFSPKQVKRPLSSIENSQSPSPKKAKAVKDGKSTGLSPEQKHRMEEKKKDAMEKLKMKKTEISPINSIKNGPDGIGASWAKALSSEFSKPYFIKLQEFVAAERRSHTIYPPSHQVFSWTQACDIKDVKVVILGQDPYHGPGQAHGLCFSVQKGVKPPPSLANMYKCLMKDIDGFEHPGHGHLIGWSKQGVLLLNAVLTVRANNPNSHKDKGWEKLTTAVIAWLNSNLNGVVFMLWGSYAQKKGSIINSKRHHVLKAVHPSPLSAHRGFFDCGHFSRTNKLLQKAGKEPIDWTRLSDEN | 173 |
Q5APR8 | 2.7.11.1 | ACT_SITE 808; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTSIYTSDLKNHRRAPPPPNGAAGSGSGSSSGSGSGSGSGSGSGSLTNIVTSSNSLGVTANQTKPIQLNINSSKRQSGWVHVKDDGIFTSFRWNKRFMVINDKTLNFYKQEPYSSDGNSNSNTPDLSFPLYLINNINLKPNSGYSKTSQSFEIVPKNNNKSILISVKTNNDYLDWLDAFTTKCPLVQIGENNSGVSSSHPHLQIQHLTNGSLNGNSSSSPTSGLSSSSVLTGGNSGVSGPINFTHKVHVGFDPASGNFTGLPDTWKSLLQHSKITNEDWKKDPVAVIKVLEFYSDINGGNSAAGTPIGSPMINSKTNNNN... | 99 |
Q2UUD6 | 3.2.1.21 | ACT_SITE 281; /evidence="ECO:0000250" | MKLGWIEVAALAAASVVSAKDDLAYSPPFYPSPWADGQGEWAEVYKRAVDIVSQMTLTEKVNLTTGTGWQLERCVGQTGSVPRLNIPSLCLQDSPLGIRFSDYNSAFPAGVNVAATWDKTLAYLRGQAMGEEFSDKGIDVQLGPAAGPLGAHPDGGRNWEGFSPDPALTGVLFAETIKGIQDAGVIATAKHYIMNEQEHFRQQPEAAGYGFNVSDSLSSNVDDKTMHELYLWPFADAVRAGVGAVMCSYNQINNSYGCENSETLNKLLKAELGFQGFVMSDWTAHHSGVGAALAGLDMSMPGDVTFDSGTSFWGANLTVG... | 161 |
Q6FJV0 | 2.4.1.18 | ACT_SITE 358; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q04446"; ACT_SITE 419; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q04446" | MSLTKIPENVQGAVSIDPWLEPFADVLSERRYLADKWLYDIKHATPDGSEQSLVDFARNAYKTYGLHANQQTKEIVYREWAPNAQRAFLVGEFNNWNEESHEMKHKDEFGVFSITLAPLENGDFAIPHDSKIKVMFVLPDGSKVYRIPAWITRATQPSKETAQKYGPTYEGRFWNPPNSYQFKHQRPKFNLANDSIKIYEAHIGISSPEPKVASYKEFTQNVLPRIKHLGYDAIQLMAIMEHAYYASFGYQVTNFFAISSRYGTPEDLKELIDTAHSMGILVLLDVIHSHASKNSEDGLNMFDGSDHQYFHSLTSGRGEH... | 73 |
W5M9K3 | 3.1.3.48 | ACT_SITE 368; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 370; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MDESQELTELPAKKARHELKDSEEKGPRVEGMAENDSQLGGGESAVLKTDSDTYTLSGETQLGEGELSKEREGYYSFHGCVVTHINENSLLLSVTCADLNTKTSNEYTSQMYQTSKPYTHILSPAITSYSTQSQFPAVAQSTIYTAYPQGSQNYGLPPFGAMWPGIKSESGLSEVPPVGQPSFLSFSTGYTSTPPGQAHYSYPSQGKWSPSLYITSSFTTSSVYTNIPSGTAATTATATVTNQEYPNYTPLGQSQYPQYYAAPSYVSAGMPNNSGGTESVNVAGYPSMKTDSPATADLLTATELVNVEVLKITLLFPDSA... | 149 |
Q11119 | 3.4.19.12 | ACT_SITE 309; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 730; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MSCPHLTETNVVIPDNSQVIYREECVRCFNSQDEEGGIDLCLTCFQSGCGETGLKHSLVHFEQTLHPIVVTIARQPKQKINDEPPQKITKLEIREDSDEDLYDYFYVPKCLVCNIILDIQDPLLSLSLEAMKNATKASNKSQLTAWENELTTCDHIINLPENETYVTNLDNATCSKCDLAENLWMCLTCGALSCGRKQYGGGGGNGHALSHYDDTGHPLAVKLKSISPDGQADIYCYSCDEERIDPNIKTHMLNFGIDIAKLNKTEKSLAELQLEQNLNWDFGASEEDDASKRLFGPGLTGLKNLGNSCYLASTMQSLFS... | 175 |
Q57983 | 2.1.1.37 | ACT_SITE 77; /evidence="ECO:0000255|PROSITE-ProRule:PRU01016" | MNVIDLFSGCGGFSKGFLDENFRILGAIENFKPVVKTYLYNIKAPVWMDDIKRIPPKAFDEFIKNEKVDVIIGSPPCEPFTKANKLIKDNPLDRLYKDKVGRLVLYYIDYVNYFTQRNDDLIFVMENVPQIKEIKDELKKLFGDIGHKVYFNILRAEDYGNPSKRARMFISNIKLKPKKVDKLVVVEEALKDIPKDAKNHEIKKLSKEKVEMISKLKWGEALYRYRGKKKLMFNWYKLHPKKLAPTVKGRSRFIHPYEDRLLTVREQARLMSYPDDFVFFGGRDVQYNQIGESVPPILGRAIAKEIKKQL | 47 |
Q7S6N5 | 2.3.2.26 | ACT_SITE 1113; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFPTFTGSSRKGRNVNLSGQRTSNPFTSTSWGAGSATGASKTVAHAQAERQQRQQERDRLRAAQRIQRTWRGHRVRRTLRDEQRQAIDRLYEAQPVDAGQRSAQALPLVFAAFQAFNVQDRHRLALVTEDLLQTDFSAFSLVFLGWDKLGKLRRILLAALTRCDLGNEQTQVALFLRALDAIRTKTSDFETFGQVLGEWYKVLGRLCQETGLPSSVQELICSLVVAPLDVPHDLDFKHTAYQNLVVSFLTQPGPARCSDLITRLAANIDLDRLSNYIIDLSHKLSKHDPNAVLWLIAHYIAINGAKEQRSSRLLFIKTLE... | 65 |
P53685 | 2.3.1.286 | ACT_SITE 310; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MNILLMQRIVSFILVVSQGRYFHVGELTMTMLKRPQEEESDNNATKKLKTRLTYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNITSNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRLRLPNFNTIDHFTATLRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAHMVLPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVT... | 58 |
A0A2K1IZH0 | 3.1.1.11 | ACT_SITE 475; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDTPGKGPLQAGTSPSGKQRSNFKGCCIFFVLVAAVILVAAAVLIPTVLIPRLRDKDKPAGHISKALDRIALACNITRFPDTCKSTIVGTTAAESDSIWIPNLAVAAATDAVTSILSRCRAYNLDPEVIFNATYGSIVDDCLEILQYGLQYLTSSSETLSKFPGPEQNREPPINELRTWVSGALTVTGACSDTLSRIQTVKSAPLRQQANQTFQVVSNALAIVNSFAVYGDDLEKWQPAYFLGNSRGPLSKSARRMLLSTEDSPQFKLRRSNPLSISGGSCESSPNHNSCSSTTGSSLNVAGSLPNWLRSQDRRLLLEES... | 125 |
A0A2C9V7Q3 | 2.1.1.37 | ACT_SITE 462; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MGKARKREGPAPAGDSFPTQEEDPITLLSSKAKKTKKAKLDSELSLVGDPIPAAEARKKWPLRYKSQNKLKKGGVPESANGESGEEEDVLQAKSHYTQAMVDGVLYKLGDDAYVKADDGNPDYIARIVELFETTEGEPYFNAQWFYRIEDTVIKDYAQSAESKRVFLSEIKDDNPLNCIVSKIKIALVAPNMDLAAKEQKIPPCDLYYDMKFTLPFLTFQTMKTDNSARDSGSSSTISSESDSNNSTIDVNDAVAKPSKAHRREKSELYLLDLYSGCGAMSTGLCMGASLSGVKLVTRWAVDINPNACKSLKINHPETEV... | 47 |
A0A2K3DIL4 | 2.1.1.33 | ACT_SITE 190; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MSPKRQREEGSTAEGDKGDKGQKPQKEEVAHPRKRFYRARAHSNPLNDASFDVPTRPEDYDWSEHYPELMAEWRERQAAAGAAAAAAGGAGAEGAASGAEEAPAVRFVDIGCGFGGLLIKLATHYPDTLMLGMEIRDKVTAYVRERIAALRRESPGSYRNAAVLRTNAMKYLPNFFRKGQLTKMFFLFPDPHFKAANHRRRIINTQLLTEYAHLLAPGGWLYTISDVPELGEWMKSKLDGHPLFERVSEEELERDVAAGLLALSSEEGQKVARNGGATYRNVYRRLAQPRPQE | 45 |
Q7URN0 | 4.2.1.20 | ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MTPLQSLFESLRGQNRKALMPFLTTGDPNIDTTEAVIAAARQAGADLCEVGVPYSDPIADGPVIQASYQRALDAGFKLQHVWDLGQRLTENPKVKAMPRVTMVSYSIIYRIGMAKYVDQAMQAGYCGAIVPDLLVEEAEDLSKICREKGFDLIQLVTPTTTRDRQCRIAELSSGFLYYVSVTGITGERTALPTNLVDNVGWLREQTELPICIGFGISGPETAAQLAPVSDGLIVGSAIVRRVADAVEKAKSSGADPVKTAAEEAGDFCHSLRQAIDAA | 202 |
Q54TA1 | 2.7.11.1 | ACT_SITE 615; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MIIINKYIRMNKIAILFSFFILICCTGYSISYKINGINENKVLSLSSSPSPSSSSSSSQILEKGKEEIKKIKKTNKNKLLYNVAIVDLEPKLEIEQELLTRNNKKKMEMKEEMDIAMMMMKAADRTDQVSTSSSSSSFSEENKKSSSDDSAPAIQSNLTFSGYMTGGEQVCDPKSCNSPSVFTQNYLCNTSSAWANGYVFHDPVPPTGLFVVHKIVVTFTGMFNVIPPTSMVFSLVNGEENAGIFFISKSSPSQCPNCQISFSPRTLPDVDPNGLASYRYGSNNSIIFNLFETDVACIGKVTANIFYGPVAFKVNSVVPN... | 99 |
B9RFE0 | 3.1.1.11 | ACT_SITE 418; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSYGEDSKRKKRLAIIGVSSFLLVAMVVAVTVSIGFNNDGESEDDINGKNHKSKEVSASMKAIKTLCQPTYYKQTCERSLAKSAGNTTDPKELIKIAFKLAEKQIDSASKKSLTLLELEKDPRTRGALNSCKELMTMSINELRSSLEKVADFDFSQLDELMADIKTWLSAAITYEETCLDAFENTTTNAGEKMKKALKTAMEMSSNGLDIVSGISSVLTDLQIPGVSRRLLQDDIPVAGHGDISQAFPAWIDPGTRRLLSAPPSNIKPDLVVAKDGSGDYKTILEALPQIPKKSNETFVLYIKEGIYEEYVEFNRSMTNL... | 125 |
O84561 | 1.8.1.4 | ACT_SITE 439; /note="Proton acceptor"; /evidence="ECO:0000250" | MNEAFDCVVIGAGPGGYVAAITAAQAGLKTALIEKREAGGTCLNRGCIPSKALLAGAEVVTQIRHADQFGIHVEGFSINYPAMVQRKDSVVRSIRDGLNGLIRSNKITVFSGRGSLISSTEVKILGENPSVIKAHSIILATGSEPRAFPGIPFSAESPRILCSTGVLNLKEIPQKMAIIGGGVIGCEFASLFHTLGSEVSVIEASSQILALNNPDISKTMFDKFTRQGLRFVLEASVSNIEDIGDRVRLTINGNVEEYDYVLVSIGRRLNTENIGLDKAGVICDERGVIPTDATMRTNVPNIYAIGDITGKWQLAHVASH... | 36 |
Q504U8 | 2.7.10.1 | ACT_SITE 792; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQGQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSI... | 97 |
Q09291 | 2.3.2.26 | ACT_SITE 1215; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00104" | MGDEFPFHHLGYVCLNEIYKHLTLKEIFQLSFSSNQIKRSLGIASIPVKSIFVNFDSQYPKIKLIGESSQLEWVFGIPDGLEYTDVGVYKIGHFKFQCKTSGTAFYTEHYDLENAMLVVIRYMISIFKCSNSIITYLSIDLGVIEDSRAICENFVAFKKVERLSIFQTNYGVERNTLNFAQSFDWICDNLEIKNIHIGADVLEPKMVQKTNGEFDIKLCARRFEQVLTMDHIYLQHADWITSEDLLNLDVQTAMLIENNLTEQDLNAFIKQWLRSDSDKLWWLEVKGKMMFNREEVLKDLDVQDDAYRSLNTRWYVARRS... | 65 |
D6W7X7 | 2.4.1.18 | ACT_SITE 351; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 406; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MGGKYSSLDPMEIEVPEIDKLLARDPYLKPFEKEIRRRYGCFKDLLETIDENGCGLDSFTQGYKYYGLHVQPDNTIVAREWAPGAVQLFLTGDFNGWNRDSHRYKKLEFGKWELVIPPKPDGSCAIPHLSEVKVVVETQSGTKEDRLSPYATYVVEPPKDQGTIYKQKFWNPPNSEKYEFRHSRPAKPKGLRIYECHVGIATSELKVGSYDNFTDNILPRIVKQGYNTIQLMAIMEHAYYASFGYQVTSFYAASSRYGTPEQLKRLIDRAHELGLTVLLDLVHSHASKNVLDGLNQFDGTDSCFFHAGARGEHSLWDSRL... | 73 |
A0A9L0RJD6 | 3.4.19.9 | ACT_SITE 134; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MASLGRLLCVLGLFLCGAASFRLSAPRAGTSEKPIIGILMQKCRDKDMKKLGKYYIAASYVKYLESAGARVVPIRLDLTSKEYEKLFHSINGILFPGGGADLKKSGYAKVAKIFYDFSIQSFNAGDYFPVWGTCLGFEELSYLVSNKSLLTSTNTDGCALPLNFTNGTLQSRMFRNFPSDLLLSLSVEPLTANFHKWSLSMKNFTTNEKLKKFFNVLSTNTDGKTEFISTMEGYKYPVYGVQWHPEKGPYEWKIEKGISHSPNAVKAAFYLAEFFAAEARKNNHHFESDVEEDKALIYQFRPVYTGNISMFQQAYIFD | 176 |
P73717 | 3.5.4.33 | ACT_SITE 60; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972" | MDQPLPTHEDWMQMAIALAEEAGNVGEIPVGAVVVNAMGEVLATGQNRKQRDQNPIAHAEMLAIQTACRRLGHWRLNECTLYVTLEPCPMCTGAIIQARLGLLVYGTPDPKTGTIDSVFDLAASAASNHHLQSLGGVCQEQCREQLQDWFAQHRARKKQQSLVS | 186 |
A0A1S3YTP0 | 3.2.2.27 | ACT_SITE 174; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MASSSSKTLMDLFKQPAAKRLKRVSSPSSADNSFSSSLSGEDGGNKDPKNTMLTSEQKSRMEFNKSLAKAKMNLKLCSDKISKLNANGTEKASLVYQLLGDGVGYVKLEELLVEETWLEALPGEFQKPYAKHLCRFVEKEISGGVPIYPPQHLIFNALNTTSFDRVKAVIIGQDPYHGPGQAMGLSFSVPRGVKVPSSLVNIYKELKQDLGCSIPLHGNLEQWALQGVLLLNAVLTVRHHQANSHANKGWEQFTDAVIKTISQKKEGVVFILWGNYAQAKVRLVDETRHHVLKSAHPSGLSANRGFFGCRHFSQTNQLLE... | 173 |
Q54TA3 | 2.7.11.1 | ACT_SITE 171; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MESNKSSSHGDVSTSPSFLNNHHQFNNGGDIIPKKKKNRIMHVGSYEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSGKQKETCFREIDIMKLLDHPNIVKLLDVVDKREEEGTTYLIVEYVSGGELFDYIVAREYIKEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDIKISDFGLSNNIQPGKLLESFCGSPLYAAPEILKAEKYLGPPVDIWSLGVIMYAVLCGNLPWEGDSQAEISFNSVHGNYEDPTHLSAEAVHILRRMIVPNPKDRATIQELKNHPWTNIDYQEIPKSHLPPRDAVHE... | 99 |
A0A058ZWZ8 | 3.1.1.11 | ACT_SITE 191; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKSAWHSETMNFFFGKKKMLYCDFKLNCNIMDTNYGNTITVDQHGSGHFTSVQVAINSVPSGNNKWISIRINPGTYKEMVTIPPDKPCIFLQGKGRDSTIITYNSHEQTDTSATFTSSPDNIVVQGITFKNSYNRYWKESNEPPLVQALAARVYGDKCVFFECGFLGLQDTLWDVQGRHYYGSCYIEGAIDFIFGSGQSIFEDCTMNVTATLPPYRLQYSCITAQGRASPGDPSGFVFERGAVIGSGPYLLGRAYGPYSRVVFHKTLLSAGVAPQGWDPWHCQGREDNIMYAEVDCEGTGSDTSQRVQWEKHLDKTQLQY... | 125 |
A0A1U7Z813 | 2.1.1.37 | ACT_SITE 775; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MADKILRRSPRSCISHPQGKACITPSLNVAATATSDEKCVTSSPGIFSASMGTECRSSKDNSVLFPDSTEKRPPVTENGKRRMAPSLKTAEGTMPDEKLVRRSPRISSASLGTKNNNISDNSLEFIDFAKKRLSSAPEIGKSHLVLSPKTDDLTNPDEKCVRRSQRMSLASKASDNSSSKGNPLDFLDSAEKRPTLLENGKNRMTASLETDEQILLDEKYVRRSPRISLDSNKSLEFLDSAQKRPSVYHNCSRMSPYLKTADQTSPNERCVRRSPRISLALMGTENILSKGDSFELANSSQKGNDKEYVVSTDQAMLGEK... | 47 |
I1IYF8 | 5.1.3.3 | ACT_SITE 194; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 328; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAGAAVLPIAFLLCLALAGGADAAGKAVGFYELKNKKGDFSIKVTNWGAALVSVVVPDCKGNLDDVVLGYDTVAAYVNGSGSFGATVGRVANRIANSRFVLDGKAYRLFRNDGNNSIHGGHRGFGKVIWTVKEYVRDGDSPYITFFYHSFDGEQGFPGDLDVYVTYQLSSPYVLSIRMHATALSKATPVNLANHAYWNLGGHGSGDVLKHELQLLASRYTPLDKSKIPTGQIAAVSGTMYDFLAPKPVGKHMEIVPGGGGGYDINYAVDGEDQYAMRRVARVRDPASGRAMEVWANQPGVQLYTSNWVINEKGKAGKVYQ... | 211 |
Q8EHQ5 | 2.3.1.181 | ACT_SITE 169; /note="Acyl-thioester intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00013" | MQNTTLHIRHLGQQDYESVWHAMQHYTDTRNNDSPDELWIVEHPPVFTQGQAGKSEHILNPGDIPVIQVDRGGQVTYHGPGQLVVYPLLDIKRSKIGVRQLVTYIEQSIIDMLAKYTINAYAKADAPGVYVDERKVASLGLRIRKGCSFHGLALNVDMDLAPFRRINPCGYAGLEMVQCRELGGPQTVIEAGDQLIITLSQLLGYQHLVHHQGLAAS | 55 |
A0A3B6AZ23 | 3.1.1.11 | ACT_SITE 303; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPRAHPRRRRLLPVAAAAAALALLALLVLLPTAPPGGPAAPASLLRAAIAAHPSPASYAHPCADHLSLSLHRLRAALPALESGDLPAALHLASASLQCQYDCSHLLSLPAFPSHSLTSRFLNSLTPQTLTAYPKPASFYSTVAAFPARVRPAATVCKSNPACDFSNVQDAVNAAPNYTAGHFLITVSAGIYKENVVVPFEKTNVLLVGEGMGATVITASRSVGIEGLGTYDTTTVAVVGDGFRARDITFENTAGAGAHQAVAFRSDSDRSVLENVEFRGHQDTLYARTMRQLYRRCHITGTVDFVFGNAAAMFEECVIET... | 125 |
B3TZB9 | 3.1.1.4 | ACT_SITE 510; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 643; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MQFLGRLLSQAFSNPYRVKEVSAAEYSGQSRLTEDGRVRLYGNGRCWDGVLVNPQSPGVAFRLFHLDDEAEALVLFERYAGHLRPFYESSAQPLSLEVLQQLTDCVRNHPSWSPAHVAVEVGLRETFRHNRVLSCVNSTDSEDGCTPLHLACRKGDMACLQELLECHARVDITDRKGETVFHYAVRGSNPYIIELLSSAPTVGVNHLSHEGLTPLYLACQLGKEDMVRSLLKCRASCNVMGTVGYPIHAALKYSQKGCAQAILEVDASQVHSRDPRHEAVPLHWAKKAEMTQLLLKYGSEVNLTSRTADMALHIAVKRGR... | 130 |
Q1JPB9 | 3.1.1.4 | ACT_SITE 184; /evidence="ECO:0000255|PROSITE-ProRule:PRU10035"; ACT_SITE 214; /evidence="ECO:0000250|UniProtKB:P00630" | MGVLVVLLGVLSFLGRTLGGSPALHWDSTSCHLARPIPGRPLRSLSFLGKDAQGLALFHAHWDGHGRLQVCSRQDEPELTAAYGALCAGEITRGSFIHTPGPELQRALATLQSQWEACRGPAESPAGTREKRAAGQNGVPGIGRQWVKRGWTVPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPHNVSPFQYNYGIRNYRFHTISHCNCDARFQQCLQDQRDSVSDIMGVAFFNVLAIPCFVLEEQEACVEWYWWGGCRRYGSVPFARLQPRTFYNASWSSPATSLTPSPQNPALSRPQPMQHPQQWPSEWKESKS... | 130 |
Q69IM9 | 2.7.11.1 | ACT_SITE 234; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGGCSSAFAVSTRMIRFSRGRVPAAILPVTSNDEPCCSCSPENNNKNNDGGGGGCDGGEHQKGKSWRRWQYRRCGGGGGGGGGRKNAILGDAADVKTAAGFAERYRLGAELGRGEFGVTRRCSDAATGEALACKTIRRKRLRRCRGDAEDVRREVEILRRISALGAGADSVVRLRDACEDSDGVHLVMELCEGGELFDRIFARGHYTERAAAKLARTIVGVVQLCHENGVMHRDLKPENFLFANKSEDSPLKAIDFGLSVFFKPGERFTQVVGSTYYMAPEVLNRSYGPEADVWSAGVILYILLCGVPPFWGDNDEKTVT... | 99 |
A0A3B6EM98 | 3.4.19.12 | ACT_SITE 24; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 24; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 133; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 148; /evidence="ECO:0... | MDAAGAGASNGGLLYHEVQEGKLCAVHCVNTALQGPFFSEFDLAALAADLDQRERQVMLQGAQGAATVAAGDFLDEGEGSHNVSLGGDFSIQVLQKALEVWDLQVLPLDSPAAGSSLFDPELEIAFICHLQDHWFCIRKVNEEWYNFNSLYPAPEHLSKFYLSAFIDTLKGAGWSIFAVRGNFPKECPMATEGSNGFGQWLTPEDARKITASCNQVPAPTHQGAVSQLGGQSAGMSEMDIIAAQQEEADLNAAIAASLMDAGGPFGSHSAPQEESRPQPSYVVEQGANVTTSVAVGEDSYVVEQGANEAEASEPGSDTIE... | 175 |
A0A9R0K113 | 3.5.4.5 | ACT_SITE 81; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1" | MDHHLKFVISASEAETMAKQQGFKSVLNLLPFIAKSSKKLARRPISGFSVAAVGLASDGRIFIGVNVEFPGLPLHHSIHAEQFLITNLSLHHHHHQPYIKNVVVTAYPCGHCRQFLQEIRDAPEIQIFVLKSDKSDCPDDELDQFMPLSYFLPHRFGPDDLLDKDVPLILENRDNNLVLLDRENNVENGGLCNGFSKSEERGVVLAALEAANKSHAPYSGCPSGMALIDKDGVIYKGSYMESAAYNPSMGPAQAAIIAYMAAAAEGGEGGGDYERIVGAVLVEVEGAVVRQEETVRLFLNAVIPKCEFHVFHCQKSGSGN... | 187 |
B9SWU5 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSSETMSSCVVLVLFCSLATLSSASLRVGFYKSSCPSAEAIVRKTVKKFVSINPGLAAGLIRMHFHDCFVRGCDASVLLQSTPGNPSEREHIANNPSLRGFEVIDEAKAKLEAVCPKTVSCADILAFAARDSSYKLGGVNYAVPAGRRDGLVSNMAEVAQNLPPPSSNAEKLADSFSRKGLSEDELVTLSGAHSVGISRCSSFSNRLYSFNATHAQDPSMDPKYAAFLKTKCPPPNPIYEAKVDPTVGLDPTPNRLDNKYYVQLSNDRGLLNSDQTLMKSPFTQKMVLDNAKSGAAWTAKFAKAMVHMGSIDVLTGPQGE... | 14 |
A0A337SRA7 | 3.1.3.1 | ACT_SITE 112; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MQGAWVLLLLLGLRPQLSLGTIPVEEEDPAFWNRQAAQALDAAKKLKPIQTAAKNLILFLGDGMGVPTVTATRILKGQINNKLGPETPLAMDHFPYVALSKTYNVDRQVPDSAGTATAYLCGVKANYQTIGLSAAARFDRCNTTQGNEVVSVMYRAKKAGKSVGVVTTTRVQHASPAGTYAHVVNRNWYSDADMPAKARKEGCQDIAQQLISNVDIDVILGGGRKYMFPKGTPDPEYPSDATQNGIRLDGRNLVQEWQARHQGARYVWNRQALLQASQDPSVTHLMGLFEPGDTKYEVHRNHTRDPSLMEMTEAALHLLR... | 141 |
Q8ZU41 | 2.3.1.286 | ACT_SITE 123; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MAVDFTTDELDEVASLIARSSCNVALTGAGVSTASGIPDFRGPQGVWRRVDPEKFEISYFYNNPDEVWDLFVKYLLPAFNVKPNPAHYALAEMERLGKLCAVITQNVDRLHQAAGSKNVIELHGALEYAVCTNCGSKYALAEALKWRKSGAPRCPKCGGVIKPDVVFFGEPLPQDALREAFMLAEMAEVFMAIGTSLAVYPANQLPLVAKKRGAKLVIINADETYYDFFADYIIRGRAEEVLPKLLDRLRGMLF | 58 |
Q0UHY1 | 4.6.1.16 | ACT_SITE 133; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 141; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 172; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MEESVAGEVTVPADPVEDSASGLGFIMKGSSFTDSSSVASTAASHASTADTSLFDSTPASPAPSVVGSIARPSLGQRHFVTPTTSYPPIPNPLDASSAQLPTVPKSYPLFRYLHSLGYYHMPGLRFGCHYNSYPGDPLRYHSHFAATGMGWDDEFELLDIVGGGRLATGTKKAYMIGGEDVDVVKKKQLASEEPDLFSDDTKEEGREVRAFSIEWAAI | 207 |
H9GN04 | 2.3.1.48 | ACT_SITE 320; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038084-1" | MRGDWQRSKRLPYSLPLPPRANGSSHFLFERHFRRVGARLDSLKLADFAGAATGEMAGLSAMEKKLTEYKCDTNEAIHLKLVRFPEDMEDDSTTFHPEFSHQVFGDDEVAFGYKGLKILLYYVAGNLSTLFRVDYTSRVNENFDCMEADDVETKVREIIPPGFSRSTDDFISLLEKEVNFKPFGILLHSYSVHNEEAGDDITYQIYKADMTCSGFREYHERLQTFLMWFIETANFIDVDDERWNYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILPPFQGEGHGAQLLETVHRYYMSSPTVLDITAE... | 61 |
Q54IF2 | 2.7.11.1 | ACT_SITE 296; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLKDIYNSLLSKKQEESNMAAWNNEDILETQAQLFFSIKSIKGLKIMDNPIKVYCLASLEKQSVQTSSIVINKDQSQIEWNEGYTFDVISSKSILALSIWQGNANVTIANNSIEGGGSSNNSKLVGKLYIPFATFKKQFCDQWFPLTGTSQSVSIHVKTSFTNSSKKVTVDDFIFLRMIGRGAFGQVNLVKKIDTGRLYAMKVIKKDKCLNMNAVGHTFTERKLLKKYYHPFIVGLKYSFQTQDSLCMVLDYIGGGELFYHISERETFSEETARFYIGQIMLAIGFLHEHGVIYRDLKLENLLMDLDGNICLVDLGLCKE... | 99 |
P44325 | 3.5.4.5 | ACT_SITE 103; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01558" | MQDLIKRTLPQDDALNQAIVNDLRSQNWAGFLNYSQVQQLCHNFELTTLKLAMHLLPLAASYSHTAISHFNVGAIAIGEQGDFYFGANQEFANSAIQQTIHAEQSAISHAWLRNERRISDMVVNYTPCGHCRQFMNELHGAEKISIHLPHSQNNPLHSYLPDAFGPKDLDIAAHLLAEENHDLVADHQDDLVNQAILAANQSHCPYSNSPHGIAILFKNSDVVTGRYAENAAFNPSLPALQTALNFAYLNDKKLSDIERIVMAEKALKLSHKTMAETLLSTLTSVELEYYSL | 187 |
Q6C497 | 4.6.1.16 | ACT_SITE 201; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 209; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 241; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MIQIKRINDKYLVFKVEDIRFLRQEHLIGGTLIGTLPQIPQQNVFCGLPLQLFKEEVIFLMKNGIAEVVDDSASHVTALTSQTPEDIENYEKQRHTAQQLQIKEYTEGMLERRRQALEKKGMSGKIDKEVVVATDNAISYVTDATTTNETLEGYNMFSKENVLSDLLEHVTSAQYYIFNFLHSRGYFLSPGLRFGGNFLAYPGDSVRYHSHYIAIGKEYEEKFPIKSVIVGGGRLGTNVKKCLVLGGENDEGGDSVYCIEWSGFG | 207 |
A0A067F5U5 | 1.11.1.7 | ACT_SITE 103; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKSKQFTLFALILVQILEQFMINVLAININNNNNILPLEHVTTTSLLTNNEASKLLLSPESYLSLSHYHSTCPDLEGIIHRQVQAWIRKDYTFAASLIRLHFHDCVVRGCDASIMLSHKGSERRAKVSKTLRGFRIIDEIKAEVEKKCPKTVSCADILTAAARDATVVAGGPFWEVPFGRKDGKISSAREANRLVPQGHENVTTLIQIFRDHGLNILDLVVLSGAHTIGRSSCDAINHRLHNFNGTRKADPSLDTKYLNSLKKKCAASSHVYVDLDATTPRIFDTAYYTNLGRNMGLLSTDQLLNSDARTGPFVSVLASQ... | 14 |
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