Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q54VU4 | 2.7.11.1 | ACT_SITE 684; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNTHNNNYQQRSMDSAIVTINDKGYIQSVDRKTCELFGYTIEELQLQKVNILVPSPYKEQHDTYMQSYFETGVRKIIDKSRVVEGLHKDGSVFPITLSVTEVRIWNKRMFIGSIESIIDKRLIIYTDVHGIITYCNRNVEELIGYTPAELFGKNVSALMPSPHAKSHSEYIEKNYHGGGLWKMLNRVRNLPIKHKSGVVFLVSILVTKISTDGIDMFKAIIQTPPKEAVFTINGDGIIKACNFNFTEPMFGYTQKDLLGNTIGLLIPEMSKIIDNTSLNLTDSHDPQLQQQQQTTTTTTTTTTTTSTTSTTTSTPTPASI... | 99 |
H3G8B7 | 3.2.1.21 | ACT_SITE 170; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 380; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1" | MAHERQFPDGFMWGAATAAYQIEGGAQEGGRGASIWDAFSHTPGKTRKGQTGDVAIDHFHRYKDDVALMKQMGLKGYRFSISWSRIIPAGVGEVNEEGVDFYNNLINELLANGITPYVTLYHWDLPLALQTEFDGWLGAGSQLHEAFAAYARVCFQRFGDRVKNWITLNEPWVHSVMGFALGVHAPGRKHNGDSEPYKCGHSLLIAHSRAVDVYRKEFQELHGGQIGITLSADWRLPGPTDDPMQMEKNIAAAERSIAFHLGWFADPIYKGDYPQIMKDRLGDRLPKFTEEQKKLLKGSSDFFGLNNYSSSFAKPSDSYK... | 161 |
A0A803SWF1 | 1.11.1.24 | ACT_SITE 91; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1" | MATGWRGAGVLVLAGRAAAAAAASPFGNTWALKWRTFATGAAAMAALKVGDKLPSVEVYEGDPGTKVNLASLFKGKKGVLFGVPGAFTPGCSKTHLPGYVEKAGQLKGKGVEIIACLSVNDVFVMKEWGNAHHAEGKVRMLADPTGAFGKATNLLLDKEPLRDLFGTNRSKRFSMVVDDGIVKSLNVEEDGTGLTCSLATNIVSQL | 12 |
A0A6I8MZE3 | 3.4.25.1 | ACT_SITE 87; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | MMIFLFSSSRLPLSPPPASFPAGSWGFFLRHRLPGPGRAPRRKMAAVSVCSPPLGGFSFDNCRRNAALEAEFAKKGHKLPAARKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDNFKPDMEEEEAKQLVRDAIAAGIYNDLGSGSNIDLCVISKTKLDFLRPYAVPNKKGVRYGREKGEMGNTSPPGLSFKTLLFRLAAEGDSAPEGT... | 180 |
A0A804K555 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGVISRGRSVLFVVLILAMASSTYASLAVDFYKERCPFAESIVRATVQMAVAVNPGLAAGLIRMQFHDCFVRGCDASVLLDSTPWSKAEKESPANKPSLRGFEVIYAAKAALEARCPSTVSCADIIAFAARDSALLAGGIHYSVPAGRRDGRVSLESEVLGNIPLPNFTVTDLLSSFAKKRLSLDDMVTLSGAHSIGRSHCPSFAGRLYNFSPSQPQDPSMDPALAAYLKSQCSPATVNINSTDPTTVHLDGVTPKRLDNQYYKNLLTHRGVLFSDQTLQASPLTAGTVSCNAENGPAWAAKFAAAMVKMASIDVLTGSH... | 14 |
Q9BYT3 | 2.7.11.1 | ACT_SITE 238; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGE... | 99 |
P55305 | 1.11.1.6 | ACT_SITE 93; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 166; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MATSITAGLQKAQQAVQDTATKNKKIVDISHDTVNVHTDQEQRTDFGVAITDPDHWLRVTNETHSGPSLLEDHIARERIHRFDHERIPERVVHARGTGAYGNFTLKESIEDLTYAGVLTDTSRNTPVFVRFSTVQGSRGSADTVRDVRGFAVKFYTDEGNWDIVGNNIPVFFIQDAIKFPDFVHAVKPEPHNEVPQAQTAHNNFWDFVYLHPEATHMFMWAMSDRAIPRSYRMMQGFGVNTFSLVNKEGKRHFVKFHWIPHLGVHSLVWDEALKLAGQDPDFHRKDLMEAIDNKAYPKWDFAIQAIPEEDQDKFEFDIFD... | 13 |
P34925 | 2.7.10.1 | ACT_SITE 465; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKV... | 97 |
W5ND67 | 2.7.10.2 | ACT_SITE 686; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1" | MGFGEELWCAQAHSSLLRLQDSELRLMEVMKKWITQRAKSDREYSAQLHQMSVTVEKLDGPQHGGGLDYISQLNKSWSTLVNQTENLSRILRKHSEDLSSGPLSKLTLLIRDKQQLRKTYGEQWNNLNQELSRVTQADLEKMKSCYRQLVRDTVQAKKKYQEACKDKDREKARERYIKQTLKLHEMHNEYVLSVKAAQLHHQHHYSQAQPALLNALQTLQEEMVLVLKEILQEYFDLSSLVQEEVVSVHGEIASAIVAIEPRREYESFIQQNRSVVEVPPNVVFDTSLLEETDNLIAGELELNELTLEGIQHRLTSLEEE... | 98 |
B9H362 | 3.4.21.92 | ACT_SITE 177; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 202; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MEVGLAYLTASQSTSSPLCFSSRNSFINKNHLLLPVTIDTSTTISVCSKRRKPICVKASKSSFDANTARQTLASNWDVEKFSSFANSAPTLPKFEELDTTNMLLRQRIIFLGSQVDDVTADFIISQLLFLDAEDPKKDIKLFINSPGGSVTAGLGIYDAMKLCKADVSTICLGLAASMGAFLLSAGSKGKRFCMPNGRVMIHQPLGTAGGKASEMSIRIREMSYHKIKLNKILSRITGKPLEQVEVDTDRDNFMNAWEAKEYGLVDEVIDDGKPGLVAPLTDASPPPKTRVWDLWKIEGSKKAKNNLPSEHKMLQNGYVG... | 179 |
A4L9P5 | 2.7.11.1 | ACT_SITE 315; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVANFNIPAYDQGLLLQAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPEN... | 99 |
A0A1Z5RMP3 | 1.11.1.7 | ACT_SITE 112; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSSLGTPARRAICLLAAVSIVLSTVSLRCDASRSSADFSPDDDDYGHDENGGNSSSSSFSFTFQPETSSPGLVFGFYDETCPDAEDIISSTMRKLYHSDPNVAAALVRLFFHDCFIHGCDASVLLDVVDGGRKSERDAGPNQSLRGMSAIEEIKRRVEAACPRTVSCADILALAARDSVVLVGGPTYPVLTGRRDSAQSFYHDAAAGGIPSPNATYGMTLAAFARHGREFTERETVALLGAHSIGKVRCRFFADRIWNFAGTGAPDDSIDPDMVGEMRAVCGGSGGDDGDGDDDGAAAMEMGYYRQGREVGFGAHYYARL... | 14 |
Q0D715 | 2.7.11.1 | ACT_SITE 178; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGLCSSSSARRDAGTPGGGNGAGNKDNAGRKGIVACGKRTDFGYDKDFEARYALGKLLGHGQFGYTFAAVDRRSSERVAVKRIDKNKMVLPVAVEDVKREVKILKALQGHENVVHFYNAFEDDNYVYIVMELCEGGELLDRILAKKDSRYSEKDAAVVVRQMLKVAAECHLHGLVHRDMKPENFLFKSTKEDSSLKATDFGLSDFIRPGKHFRDIVGSAYYVAPEVLKRKSGPESDVWSIGVITYILLCGRRPFWDKTEDGIFKEVLKNKPDFRRKPWPNITPCAKDFVQKLLVKDPRARLTAAQALSHEWVREGGQASD... | 99 |
A0A6P9EST4 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAIVFEPKAQSFTQSFLLFLMVSLSRVELDAHYYDQTCSQAEKIILGAVSNASMHDPKVPAXILWMFFHDCFIRGCDVSMLLDXTPGNQVEKEGPLNISLCSFYMIDDVKTKLEMAYLHTVSCADIVAIAARDVVTTMGGPYWNVLKGRKDGRVSKAVETINLPAPTFNVIQLIQSFAKRGLGVKDMVALSGAHNLGFSHCSSFEARLHNFSSVHGTDPSMNDEFAENLRKKCTKPNKDQNAGEFLDSTLSTFDNEYYKRIMARKGVLGSDQALFGDYRSRWIVEAFAKDQSLFFKEFAASMMKLENIGMIENDEVRLKC... | 14 |
Q8ZSY7 | 6.3.4.2 | ACT_SITE 378; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 504; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 506; /evidence="ECO:0000255|HAMAP-Rule:MF_01227" | MPKLIIVTGGVMSGVGKGVVVASIGRILRARGLSVNAVKIDPYINVDAGTMNPYAHGEVFVTYDGGETDLDLGHYERFLDVELSKRNNITSGQIYLTVIEKERRGEYLGQTVQLIPHVTDEIKRRIVEASGGYDVTLVEIGGTVGDYEQLPFLEAARQLGLELGEDVVFIHVAWVPLLKITGEFKTKPLQHSVAELRRYGIQPDAVVVRSEKPIDANSIKKIALFAHVPQWAIFNSYDVDTIYRVPLILEQQGLGDFLTRRLRLPSRSPEYRDWEEFLSKLSAPKYRISVGMCGKYVELPDAYLSIVEALKHAGAALDAR... | 252 |
B3RM02 | 1.11.1.24 | ACT_SITE 67; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1" | MTSVSLVTTFARRFSSTSRLLQIQVGDKLPSIALHQNSPGNKVDIRQLFANKKGILFAVPGAFTPGCSKTHLPGYLQHYDNFKSKGIDVIACVSVNDAFVVDAWSKSNNVDDRLEMLADTSAQFTKSVGLDFDATPVLGNIRSKRYAMIIEDTVVKQINVEPDGTGLSCSLAQNILEQLS | 12 |
Q74K78 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 339; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MSVITDIHAREVLDSRGNPTVEAEVYTELGGFGRAIVPSGASTGEHEAVELRDGDKSRFLGQGVLTAVENVNGEIAKAVIGLDVTDQRLIDQTMIDLDGTPNKGRLGANAMLAVSLASARAAADELGLPLYEYLGGPNAHVLPTPMMNVINGGKHADNNVDIQEFMIMPVGAKSLHEAVRMGAETFHTLKSLLQERGESTAVGDEGGFAPNLKNNEEPFEILVEAIQRAGYKPGQDISIAFDCAASEFYNKDTKKYVTVADGREYTAEEWTSLMEDIVDKYPVISIEDPLDENDWEGWKVFTERLGDKVQIVGDDLFVTN... | 200 |
A0A3B5XVG4 | 1.11.1.7 | ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGGSSTFMPAPAMATTALILLLVFSSSPAVVAWKDSGLSVGFYKELCPKAEKVVRRVVTKAFKKEPGTPGDIIRLFFHDCFVRGCDASVLLESTPGNTAERDSKPNNPSLDGFEVISDAKEILEKLCPQTVSCADILALSARDGAFLASGLDYAIPTGRRDGLVSKEDEVLPSVPHPDFRHDQLIENFTAKGFTAEELVTLSGAHSIGTSHCSSFTDRLYKYYNNGAYGTDPAIPAAYAARLKKKCPPSTAAHNDTTMVQLDDVTPFVMDNQYYKNLLAGTVAFDSDMALMDDPETAALVDLYAREPSDYWTKRFAAAMV... | 14 |
Q0E2F9 | 3.4.19.12 | ACT_SITE 450; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01035"; ACT_SITE 706; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01035" | MLQPRESDVPVLFVVFIVLPVIAYFLLGRWHDAVSKKARVSVLAQRAAEETFKVETMATPDVILPGPSLRPMPYMRSAPSARPEYHECATCHGPAKTRCSRCKSVRYCSGKCQIIHWRQGHKQTCQQWNGFGTSSSGGLPPTENTEQMPFLSNLNSPLRGSDVHLHDMDFDTMSEPSFVTTDSYNLDTSPFLSDRSNMNKPNQFLHTSENGAAIGSYEKNDYSIDGEVPSSEILSGNKGLNNSSGSGENCGNRDVIYPLNSVVHQPNNYAPEIRKRPKASITVYESDKGVYLTSDMISSGEGPYASAAESLQRSNSSGNV... | 175 |
Q758H0 | 2.7.1.11 | ACT_SITE 359; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MSVETAYGVAFRSLATTDERLYKATVQFYKRLSFATVKLYDKFKNHGDEMLLSGTSQSSRHETWLMSFKLSEVDSSGCRVPQQEAERKLQSDGAMIKVRLVNEVAAADCGALRVSYYSGSFAEAAAAFPDREEVSEHEFRIRDPLGNEIALTDTPHLHDAVLGEQAVGADFFLSGSGETHRLAQGRETAAALMRSLRETPGAPDSKPKKKLAVMTSGGDSPGMNAAVRAVVRAGIYYGCDVFAVYEGYEGLLKGGEYLKHMQWSDVRGWLSEGGTLIGTARCMEFRERKGRKQAAANLIEQGIDALVVCGGDGSLTGADL... | 84 |
Q9U720 | 2.4.1.12 | ACT_SITE 370; /evidence="ECO:0000255"; ACT_SITE 717; /evidence="ECO:0000255" | MDRNEGGDFPINTPNNINSSGGSYNNSMNNSSNNIGRDIGNNQSSRNLKPKPSQSNLKWIARDLKKKSVRKDSERKLKSSGVLKKKNTVMDFGEDDGGSGDDGNITEGLPISEGMDDLPSSSNSRGGSGNDEQKKQFPKEMNSPSSEYGTTSGGQRFDTLVDPDISLAEMEEKMRQHKVYQEQQQQQQQQQQQQKQKDKELSSQKKKPSSMQLSKKKHVAKEDSETLETIIGEEKKEVVFEVKPYFSHAILQATMAVFLIWNIFYFAYRAGWTMNRTDYITFSYSILFIIVEFISFLGSALHLNNFTNPCTFVLVVTLEQ... | 70 |
P50903 | 3.1.1.3 | ACT_SITE 169; /note="Nucleophile"; ACT_SITE 193; /note="Charge relay system"; ACT_SITE 280; /note="Charge relay system" | MLLLWILSLFLETVAGGEVCFDRLGCFSDNKPWAGTSERPRKGLPWDPSAINVRFLLYTNENPNNYQRITADSSVIRSSDFKTDRKTRFIIHGFIDKGEENWLADLCKALFQVESVNCICVDWRGGSRTLYSQASQNIQVVGAEVAYLINFLQSQLDYPPSSVHIIGHSLGSHAAGEAGRRTNGAIGRITGLDPAEPYFQYTPEIVRLDPSDAQFVDVIHTDGNPIIPNLGFGMSQTVGHLDFFPNGGLQMPGCQKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYIDSITNPKGFAGFSCDSYSSFSSNKCFPCATGE... | 128 |
A0A022PUV6 | 2.3.1.181 | ACT_SITE 179; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MRVPRTIEIRKMGNLFNYSDALKLQEKLASDRKMNKITDTLLSLQHPPTYTLGKRRTDHNILVPECELKSMGAELHYTQRGGDVTFHGPRQAILYPIISLREFGLGARKYVENLELTMIELASLYGVKASVGRKCETGVWVGERKIGAIGVRISSGITSHGLAFNIDPDLSYFKHIVPCGIADKEVTSLQREVKQEVLLPSDELIQDQLISCFAKIFGYTNVVSRNNS | 55 |
Q54GV7 | 2.3.1.286 | ACT_SITE 411; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MNKRSLENNELNEIQNNQNKNNNNKINKEIPSDNTPLKKLKSINSLEQLQEVDEDEDLDVEIDTKLINKLDKKGRKYEFVGEGYSDEEQISDDYEDDESSEYEYGYENEDELLDDEDHLDNINEIKKIQKKLVNTETSTSITNTSSTTTTSTSTTTTTTTKTQINETILLDILNNNKDEVDDEIQRIGNNVGNSKEEEGEEEEENIELVARSFIYKHIQEKKSLGIDPIEFTKDIGFKLELEKDDDAWEIITAFLTRKKVAVNLFLNYLKYNTLARPYRKKIATLDLSTFEKVCQLFESSKNIVIITGAGVSVSCGIPDF... | 58 |
A2DKE7 | 2.3.2.26 | ACT_SITE 1136; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MEIAINNPVECNESLPIPGKDEENYLFKLAYARATFTDSNWQVSENICKIRTEHKDKILEKIEANDDENVSLGAMIALGAEIFDSEVTRYIKIKGKTELANNHDVDVQRNSQACFQIDPPKFNVTAKLTAKMIEFIDKVDLDIQATPSQKPADNSQKPLDTPQKIAEKAIKNCIILSFLSKLFDAVSDKNKFAEKFPKMKEICKKFKDTVVPNYTNSKYSYFIRQQLKRVCEKNGIKDKFIPLTHCGECKDSMFNGSPDTSSFFVHTKMIDVNNAIEISFTDMKTQLKYIGFISENWDCTFLSLLDRNIYMDKKFVPYTG... | 65 |
P78619 | 1.11.1.6 | ACT_SITE 100; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 173; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MRALGLVGLVGVANAVCPYMTGELGRRDTNPDATEATEEFLSEYYLDDTDSYLTTDVGGPIEDQQSLKAGARGSTLLEDFIFRQKIQRFDHERVPERAVHARGAGAHGVFTSYGDFSNITAASFLSAEGKETPVFVRFSTVAGSRGSSDLARDVHGFATRFYTDEGNFDIVGNNIPVFFIQDAIQFPDLIHAVKPKGDREIPQAATAHDAAWDFFSQQPSTLHTLLWAMAGHGIPRSFRHVDGFGVHTFRLVTEDGSTKLVKFHWKTLQGLASMVWEEAQQISGKNPDYMRQDLFESIEAGRYPEWELNVQIMDEEDQLR... | 13 |
D7STE0 | 1.11.1.7 | ACT_SITE 59; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MFVFLLLAKAFALVHGQGTRVGFYSASCPQAEFIVQLTVAAHFQSDPAIARGLLRMHFHDCFVRGCDASILINGTSTEKTTTPNSLLKGYDAIDDAKSQIEDVCPGVVSCADILALAARDAVVLTNGPRWLVLTERRDGRVSLASDTNNLPGFTESIASQKKKFADKGFNDQDLVTLVGGHTIGTAACQSFRYRLYNCSNTSANGGDPCMDAAFVSQLQKMCPANRDGSKRIALDTGSSDRFGGSFFTNLRNGRGILESDWKLRTDASTRAYVQRFLGLRGELNFNMEFGRSIVKMSN | 14 |
D7TCS7 | 1.11.1.7 | ACT_SITE 97; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MFIFLMYSLHFTPINRAILSSISIQPYKKMKMSAAAVALAFALVLANFANQCHGALQEGFYKGKCNVDVEKIVSGIITPLVGQKPWITPALLRMQFHDCFVKGCDASILLDGSSSEKTAPPNLSVRGYDVIDLVKAAIEKMCPGVVSCADVIVMATRDAVAASKGGWYSVQTGRRDGLVSLATNVNLPGPSVSVENSTAIFNSKGISTEDMVYLLGGHTVGVTHCSLFKDRLYNFNNTGRPDPTMQPSLAFFLRLRCPQSSTVDNTVNLDQGGSSADLLGEPTSNTVDNSFYKQIVFHRGVLQIDQALALHQLTKDTVNT... | 14 |
A0A3B6RBY9 | 2.1.1.33 | ACT_SITE 181; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MPNPDEAGGEPDAAPRGLGQMTRTSGANGGGQQGSGKLPRKRFYRARAHSNPLSDSHFPIPISPDDVDLSQHYPRYFPADKGEHGDGDGDAEAPRIRFADVGCGFGGLLVGLSPLFPDKLMIGMELRDKVTEYVKERVLALRASNPGQYDNISVVRTNSMKYIPNYFGKAQLSKMFFLFPDPHFKEKNHRRRVISMHLLDEYAYVMEAGGIIYTITDVEELGIWMRTCLEKHPLFGAVPEEEIKVDPVVKLLSSATEEGQKVARNGGQTFQAIFRRISLQEE | 45 |
Q09845 | 1.1.1.8 | ACT_SITE 236; /note="Proton acceptor"; /evidence="ECO:0000250" | MTVAALNKLSALSGSIQKSFSPKLISVGIIGSGNWGTAIAKICGENAKAHPDIFHPQVHMWMYEEKIQHEGKECNLTEVFNTTHENVKYLKGIKCPSNVFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCLKKDAVAISCIKGVSVTKDRVRLFSDIIEENTGMYCGVLSGANIASEVAQEKFCETTIGYLPNSSVNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVAVAAGIIDGLELGDNTKSAVMRIGLLEMQKFGRMFFDCKPLTMSEESCGIADLITTCLGGRNHKCAVAFVKTGKPMHVVEQ... | 7 |
B9T9P1 | 3.4.21.92 | ACT_SITE 337; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 362; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MPGRVKEFDDALIGGKAGTEKSFDITYPADHNPAQLAGKTVTYDVKFVSVSQPVYPEIDAEFAKGLGVEDGNLDTMKSEIKQSLEQEVDKRIKARVKESVFQALVDETSFELPKAIVSAETNRLMQVAAQNLRQRGVDPAQVPMEPSVFETQAQRNAKLRLVLTELVNTNNLQATADQVRAMVDSFAQSFEKPDELVSWYYADVKRLDEPAALATEENVVAWVLDKAKGMMQQRMEPQGLGYIPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDMTANLVVAQLLFLEAENPDKDISLYINSPGGSVTAGMSIYDTM... | 179 |
A7EY31 | 2.2.1.1 | ACT_SITE 418; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MGFTDVDRLAINTIRVLAADATARSNSGHPGAPMGMAPVAHVLFNKIMNFNPKNSSWVNRDRFVLSNGHACMLQYALLHLYGYKLSMDDIKAFRSIDSHTPGHPEAADTDGVEVTTGPLGQGIANAVGLAIAQQHAAGEFNKPEFELINNYTYCFLGDGCLMEGVASEACSMAGHLQLGNFIAIYDDNHISIDGDTNVAFTEDVVKRFESYGWHVETVTDGDNDLEAMEAAIKKCQAVKDKPSMIKLRTIIGYGSKQQGTHGVHGSPLKADDIKQLKEKFGFDPEQSFVVPQEVYDICHQRADHGAALEQKWNELFEKYG... | 51 |
A0A804JY76 | 2.1.1.33 | ACT_SITE 238; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MLNRLGSAAIWPFFYSIRYEPNRSSSASKPLTPPSLVRVSFLPRSRSRQSRQRYSKHPGNHSLSFALTTASQNRPRSTVAMSSNADTAQAKSRSGRLPRKRFYRARAHSNPLSDSHFPIPISPADFDCSHHYPYFFPPGSGGRSDGDAPPRKVRFADIGCGFGGLLVGLSPLFPDTLMLGMELRDKVTEYVKERILALRASNPGHYENISVVRTNSMKYLPNYFEKGQLSKMFFLFPDPHFKEKNHRRRVISPQLLDEYAYALEVGGIIYTITDVEELGDWMRSCLEDHPLFGAVPEEELVLDPVVKLLSSATEEGQKVA... | 45 |
B3NC86 | 3.4.19.12 | ACT_SITE 182; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 440; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MPVSMAVCETANVVNAALRESLGGNSSAAGSSADQAKSGEESNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLESLKSKYIVIKPGNPGAINGFGGKNNTGKVVGANGHDNNGARKQAEHPNNQSHHNNHNNHPHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLENCNVAESGGGCIVCAMAKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSI... | 175 |
A0A251S3E5 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSRMVIGFLKFTILAIILMAFDRSEAQGPLKMGFYRTTCPAAEQIVRDTVTKVVTANPGMAAGIIRLYFHDCFVRGCDASLLLKPVRGSEGESEQDSFANAGTLRGLEIIDQAKARLEATCPNTVSCADILAFAARDSTNMVGGFSYDIPSGRRDGRVSNLNDVRLPGPDSHLDTLKSSFVEKGLSVRDLVALSGAHSIGRAGCNSIVTRLYSFNGNGTDPSLDPKYATILKRKCPERPLSRKTELDLVTPNRLDNQYYRNIKQQRVPFSSDEALVDSTITARMVTNYAKNPTAWRKDFAAAMVRLGSLDVLTGTRGEIR... | 14 |
E1B9W9 | 3.4.19.12 | ACT_SITE 120; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 371; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MTIVDKASESSDPSTYQNQPGSSEAVSPGDMDAGSASWGAVSSLNDVSNHTLSLGPVPGAVVYSSSSVPEKSKPSPQKDQALGDGIAPPQKVLFPSEKICLKWQQTHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTLSLKRF... | 175 |
M4FGR5 | 3.1.1.11 | ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MALDGDKKKKCIIAGVVSGLLVIMVVSVAIIASKNSPNENEIRQNTKAVKTVCAPTDYKETCLKSLMDASPKSTEPLALIKLSFNVTIKSIQEGLKKASEDVKHKADKHPEAKDAFELCEKVMNDAIADLKKCVDHKVSVDEIERFIKDLRVWISGSIAFQQTCIDTFEEIKSTLKHDMINIFKRSRQLSSNSLAMVTDLNSNATELTGAFENNARKLLSTEEDGVPTWVGPEARRLMGAPGGPPVKANAVVAQDGSGQFKTINDALNAVPKENKVPFVIHIKEGVYKEKVVVTRKMPYVTFIGDGPTKTVITGSLNFGI... | 125 |
Q9I5R7 | 4.1.1.50 | ACT_SITE 113; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000255|HAMAP-Rule:MF_00465"; ACT_SITE 118; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00465"; ACT_SITE 141; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000255|HA... | MKSKLKLHGFNNLTKTLSFNIYDICYAETPEDLQAYVQYIDEEYDAERLTQILTDVVDIIGANILNIARQDYDPQGASVTILISEQPVTPTDSQIEESPGPLPDTILAHLDKSHITVHTYPEIHPVDGIATFRVDIDVSTCGVISPLKALNYLIHQFDSDIVTVDYRVRGFTRDIEGRKHFIDHEINSIQNYLSDDTREAYQMTDVNVYQENLFHTKMLLKDFELENYLFGDATRTLSAEQREQVTERLKHEMLEIFYARNMPR | 196 |
Q2QVG8 | 2.7.11.1 | ACT_SITE 208; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNCCVSRPSGADKRRRCGSSTAPHTRGGRRVIGAANMRCLSTVSSVSDAARAVMSNEPATVLGNSGSSGNGGVMAAEEMLRRYEIGEELGRGEFGVTRRCRDAVTGERLACKSISKRKLRSSVDVEDVRREVAIMRSLPAHANVVRLREAFEDADAVHLVMEVCEGGELFDRIVARGHYTERAAAAVMRTIMDVVQHCHKNGVMHRDLKPENFLYANASENSPLKVIDFGLSVCFKPGARFNEIVGSPYYMAPEVLKRNYGQEIDIWSAGVILYILLCGVPPFWAETDEGIAQAIIRSHIDFQREPWPKVSDNAKDLVR... | 99 |
A0A6I8PCM0 | 2.7.10.1 | ACT_SITE 865; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000631-1" | MSVRGSALGFLLLWEAALGLYFPRDTYSEKLYVDQPAGTPLLYVQALRDSQQEVPRFQLGQHLYGSYRSQLHENLWFQIHEDTGLLYLNRSLGWKDLKSLSALNGGYPLLNIHLHVFLSPKPFWENECLWPSCAKVSLSIINTTAPTCSSLKAREFCFLDTGLSFRIKENKPPGTFHQFRLLPVQQLCPNISISYQLIADAGVPFRCDKESMEVSTRRPLDREQREKYELMAKCTVRMEAREVDVVVPFPVTVYDEDDTAPYLPRGINTADAVVEYKRKEGTILAKLTVQDADVTPSSGELIRKYTNTIVTSDPWVSESF... | 97 |
A0A022PSM7 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAFHNMNQQLLVPMFLLLVATFAGLSSGQGATRLAFYARTCPRVESIVQSTVRTHFNADRTVAPGLLRMLFHDCFVQGCDASILIDGAGTEKTAGPNLLLRGYEVIDDAKRQLETACPGVVSCADILALAARDSVVLAGGPSWAVPTGRRDGLVSLASETSNLPGFTESVDSLKRKFLDKGLNTQDLVTLSGGHTIGTSACQFFRYRLYNFNSTGGPDPTIAAAFLPTLRALCPDGGDGSRRIGLDNGSENRFDNTYFANLRNGRGILESDQKLWTDSSTNTFVQRYLGVRGLLGLTFSVEFGRSMVKMSNIEVKTGTNG... | 14 |
Q07412 | 5.3.1.1 | ACT_SITE 95; /note="Electrophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10127"; ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10127" | MARKYFVAANWKCNGTLESIKSLTNSFNNLDFDPSKLDVVVFPVSVHYDHTRKLLQSKFSTGIQNVSKFGNGSYTGEVSAEIAKDLNIEYVIIGHFERRKYFHETDEDVREKLQASLKNNLKAVVCFGESLEQREQNKTIEVITKQVKAFVDLIDNFDNVILAYEPLWAIGTGKTATPEQAQLVHKEIRKIVKDTCGEKQANQIRILYGGSVNTENCSSLIQQEDIDGFLVGNASLKESFVDIIKSAM | 213 |
A0A6I8MXL3 | 3.1.1.4 | ACT_SITE 60; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 101; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | PKGLVQWVIVVQGSIYELRNMVQESTGQPAVPNYSTYGCYCSSARRGLPLDETDRCCHNHKCCHSQIRNCKLNSTYSYSFWDGIIRCISEDPCEQQLCQCDKIATYCMTHSLASYNKLYRYYPTQECVGAKMECKETLDLSASP | 130 |
B6K079 | 2.3.1.181 | ACT_SITE 209; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MLLCKTVYKPWMQGFNRSFLRFIHSKKSINHISFIKDETTCVSYNDVDSFQNQIVSQFLDFKAGKIGEHPKATFLSMQFHPVYTLGRRQRNTELINRLQAGKADVVQALRGGQTTFHGPGQLVVYPIVDLIDLQIKPRTYVSMIEQSVINTCEHFGIHGTHTTENTGVWVTDDDKIAAIGIHLRRYITSHGVAINVNTDLRWFDSIVACGLKGKRTTSFEQQGISVSIKDVESYFIKTLWNTMSKK | 55 |
Q55738 | 5.6.2.2 | ACT_SITE 122; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897" | MTDSPDRLIATDLRNEMSQSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMREPLIDGHGNFGSVDNDPPAAMRYTESRLRPLSTNSLLRDIEAETVDFIDNFDGSQQEPTVLPARIPQLLINGSSGIAVGMATNIPPHNLGEVIDGAIALIRNPEITEQELMQIIPGPDFPTGAQILGRSGIREAYLTGRGSITMRGVASIETMEHPGRPDRDAIIVTELPYQTNKAALIERIADLVNDKKIDGIADIRDESDRDGMRIVIELKRDAYARVV... | 222 |
A0A0A0LQU1 | 1.1.1.100 | ACT_SITE 236; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MAAVTGSSAVAFSKVGIVGKFEGGVDRRASSVQQWSPICNGAGSNQLRGCFGLQLRSKSSFASTGIKAQVATAEQASIKEVQQVEAPVAIVTGASRGIGKAIALSLGKAGCKVLVNYARSSKEAEEVSKEIEGFGGQAITFGGDMSKEADVDSMMKTAIDTWGTVDILINNAGITRDGLLMRMKTSQWQEVIDLNLTGVYLCTQAASKIMMKKKKGRIINIASVVGLVGNVGQANYSAAKAGVIGFTKSVAKEYASRNINVNAIAPGFIASDMTAKLGAEIEKKILSTIPLARYGQPEEVAGLVEFLALNPAASYITGQV... | 2 |
Q9FXE5 | 3.2.1.51 | ACT_SITE 37; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 345; /evidence="ECO:0000250"; ACT_SITE 348; /evidence="ECO:0000250" | MNPILSSLFALSLLSSLSPSTHAHQCHFPAIFNFGDSNSDTGGLSAAFGQAGPPHGSSFFGSPAGRYCDGRLVIDFIAESLGLPYLSAFLDSVGSNFSHGANFATAGSPIRALNSTLRQSGFSPFSLDVQFVQFYNFHNRSQTVRSRGGVYKTMLPESDSFSKALYTFDIGQNDLTAGYFANKTVEQVETEVPEIISQFMNAIKNIYGQGGRYFWIHNTGPIGCLAYVIERFPNKASDFDSHGCVSPLNHLAQQFNHALKQAVIELRSSLSEAAITYVDVYSLKHELFVHAQGHGFKGSLVSCCGHGGKYNYNKGIGCGM... | 169 |
Q5JHG3 | 5.3.1.1 | ACT_SITE 96; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MAKLKEPIIAINFKTYIEATGKRALEIAKAAERVWKETGITIVVAPQLADLRMIAESVEIPVFAQHIDPIKPGSHTGHVLPEAVKEVGAVGTLLNHSENRMILADLEAAIRRAEEVGLMTMVCSNNPAVSAAVAALGPDYVAVEPPELIGTGIPVSKAKPEVVTNTVELVKKVNPDVGVLTGAGISTGEDVKKALELGSVGVLLASGVTKAKDPENAIRDLVSLII | 213 |
Q4X0W8 | 2.3.1.48 | ACT_SITE 347; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q12341" | MALILERLYLLSSPRNAIIRNTRSEAGRELIFSFGLPSLSLPSCIASQYGKRRRLYFTTQLHVNSFLHWTCDANDAVNITLVQPDEQKLKTVSSFHPQFTYPIFGDDERIFGYKGLIIRLRFAAHDLRPQLHISYDEKFKPVEDIAAVDIPKTLKPWIPEDAFVTLPDYEKAVLEDKAAKDFKPPGKLVHCYVSRNRNFEIWAGSLADPEVRRLLDRAQIFVSLFIEAGTPLATDDPEWTLQRWTVYFVYEIVKPPTPTASKYSIVGYATTYRWWHYRRDRTQVPVVKNDPFPSGPEIHPSQLPSRLRIAQFLILPPHQN... | 61 |
Q54PA0 | 5.3.1.8 | ACT_SITE 314; /evidence="ECO:0000250" | MENNNNNNNNNNNNNNNNNNIVLLKCVSQNYEWGKYGSNSTVAKLLKGYAKECSDIIKETIPYAELWMGDHVSAPSKVEYKNKELKLREYIDTVQKEINEKSSTSSSSSSSIRGEIVEKRFGNDFPFLFKVLSIRTALSIQAHPDSQLAQVLFKKYPNIYKDPYHKPEIAIATTPFEALCSFRPLSEIQSFIDTIPEFKNSLPNNLIKLDDCKEYLKSIVTSLLKADGLLISNNLKELNNRLNEKREEERDDLDRLVLKLYSQYPGDVGVFFAYILNYIVLKPGEALFLGAGEPHAYISGDCVECMAPSDNVVRAGLTPK... | 214 |
Q1K7Z3 | 3.4.19.12 | ACT_SITE 91; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 178; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSGGWNTIESDAGVFTDLLTNLGVKGVQFEELLSLEPDALAQLHPVYGVIFLFKYPTNEPYRGTDKPLDGTFDYDASERLFFAHQTIQNACGTQALLSVLLNKADPSVSQEGDAGYIDIGDKLRDFRDFTIALPAEIRGEALSNSELIRDTHNSFARSSPFIDETQRRPDEEEGDAFHFIAYSPIGGTLYELDGLQPAPISHGACTQEDFPQKVMDVLQRRIARYDASEIRFNLLAMIRDLRIRAREFADEELLATEERKREAWRFENALRRHNFVGFAGEILKGVVSAKLAAGGSAYDDWVNQGKKKMEKRAAEQRARK... | 175 |
P28192 | 3.1.3.48 | ACT_SITE 844; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MPRKHFIFLIFLFWKFDSAESISVTSKNATEALLRCPPAENFIRTHMAPDFETPRLVRRLDWFQDDSLVASYQQDILADSSRQWWVSDGRYQLIRPFYTLRVSPVTPEDSGTYRCRLETDPLFSSPQSTATQELAVMVKPVAPSSPEIKTFTNRSITLVWTHNAARAHRPILRFSVSVRTVSDNTRFVMAAPSNATTVIVDNLSPYTLYAFSVRAENSAGSSDFGPETTFRTLGESPNRPPQIQKIRNITSECVEVTITPPDEMNGELDKYLVLIQAVNETIPRKMTFDKPTSTPLTICALSPSTDYALAIEADNGFGTS... | 149 |
A0A059D8G6 | 1.1.1.100 | ACT_SITE 241; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MAAAPAAAASASASNVVAFGSSRVPAEPRLSFPRRLSPLVGGAGSRQLRTFPGLQCEARSSSAAPGFYAVVRAQVAAVEKPSTEVAHNVESPVVIVTGASRGIGRAIALSLGKAGCKVLVNYARSSQEAEEVSKEIEACGGQALTFGGDVSKESDVEAMIKTAVDAWGTIDILINNAGITRDGLLMRMKKSQWQDVIDLNLTGVFLCTQAASKIMMKKKKGRIVNIASVVGLVGNAGQANYSAAKAGVIGLTKTVAKEYASRNITVNAVAPGFIASDMTAKLGEDTEKKILGAIPLGRYGQPEEVAGLVEFLAINPAASY... | 2 |
A0A251T4E4 | 1.11.1.7 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MMIGTIMCLAFISFLSIFISVSAFNNPSLTHSLKVPSLPDITSFEDDLSYSLYHKGCPNVEGIIYRKVKEWVKRDPSLAPSLMRLHFHDCAVRGCDASILLDHSGSERSANVSKSLRGFELINDIKAELEKKCPKIVSCADILTTAARDATVLAGGPFWTIPFGRKDGRVSLAKEAAAVPMGRESITQLIEFFQSKGLNVLDLVVLSGAHTIGRSSCEAVQYRLYNYKGTKKPDPSINPLYLNYLRRKCRWASENVYLDATSPNKFDTQYYHNLKKKMGLLSTDQLLYSDSRTKPIADALSFQSSLFYNQFSVSMVKLAN... | 14 |
A0A286ZNU0 | 2.7.7.7 | ACT_SITE 72; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MSKRKAPQETLNGGITDMLTELANFEKNVNQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKHEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRPKLLHRVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNNEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPVGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE | 121 |
O80939 | 2.7.11.1 | ACT_SITE 472; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MFLKLLTIFFFFFFNLIFQSSSQSLNFAYNNGFNPPTDLSIQGITTVTPNGLLKLTNTTVQKTGHAFYTKPIRFKDSPNGTVSSFSTSFVFAIHSQIAILSGHGIAFVVAPNASLPYGNPSQYIGLFNLANNGNETNHVFAVELDTILSTEFNDTNDNHVGIDINSLKSVQSSPAGYWDEKGQFKNLTLISRKPMQVWVDYDGRTNKIDVTMAPFNEDKPTRPLVTAVRDLSSVLLQDMYVGFSSATGSVLSEHYILGWSFGLNEKAPPLALSRLPKLPRFEPKRISEFYKIGMPLISLFLIFSFIFLVCYIVRRRRKFA... | 99 |
Q9SGG3 | 7.6.2.1 | ACT_SITE 425; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250" | MARGRIRSKLRLSLLYTFGCLRPATLEGQDSQPIQGPGFSRTVFCNQPHMHKKKPLRYRSNYVSTTRYNLITFFPKSLYEQFHRAANLYFLVAAILSVFPLSPFNKWSMIAPLVFVVGLSMLKEALEDWRRFMQDVKINARKTCVHKSDGVFRQRKWKKVSVGDIVKVEKDEFFPADLLLLSSSYEDGICYVETMNLDGETNLKVKRSLEVSLPLDDDESFKNFMATIRCEDPNPNLYTFVGNLEFERQTFPLDPSQILLRDSKLRNTTYVYGVVVFTGFDTKVMQNSTKSPSKRSRIERTMDYIIYTLLVLLILISCIS... | 259 |
Q5VVX9 | 2.3.2.23 | ACT_SITE 89; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MHGRAYLLLHRDFCDLKENNYKGITAKPVSEDMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITIPFHPNVDPHTGQPCIDFLDNPEKWNTNYTLSSILLALQVMLSNPVLENPVNLEAARILVKDESLYRTILRLFNRPLQMKDDSQELPKDPRKCIRPIKTTSFSDYYQTWSRIATSKATEYYRTPLLKVPNFIGQYYKWKKMDLQHQKEWNLKYSVIKCWLARKRMPHEVTHSMEEIKLCPTLIPTTDEIFLESPTAINSITDIYETEEEGWKSDTSLYENDTDEPREEEVEDLISWTNTLNTNTSE... | 64 |
A8XVI4 | 2.3.1.48 | ACT_SITE 707; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MKIEPEDDYSYEEKEEERRKKNLEDLRACQLNMKRVGGVTDRHLLDLTKEKTSRVQNQAYLEMMSQREGYGRDQGTSHEAPDVPFGNAPLSRSSFPVVATHSGPIMSSDTRTRSRIKVEIKQEIDDIQDYLVSSTTQTPKPKAQKSKATAPKATPKNQKKKKKKEAEEEDAYRPPHAWKNNTRYLYFAPAPARRSARLIKKEEDAIQKKLQGMKKEIVAQDLYPNLDVIPSPPDFIPSPQSNELHEDLASAAINKQIDMFVATGEAMDPEDLNEIFAGSMSVSTTDHSKPQSKREEHKNRDFNPATQQNTLPQDNRSEGD... | 61 |
A0A3B5Y4Q5 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSRERWPPLALALAVAAAVVGVLAAASPRAEAELQVGFYNATCPIAEGVVFAEMHAILHEDPTLAPSLLRMHYHDCFVQGCDGSILLRSRRGTAERDATPNRSMRGYDAIERIKARLETLCPLTVSCADIIAIAARDAVYLSKGPWYGVETGRRDGNVTVAEYAENDLAPPDSNIVDVKTFFSVKSLTAKDIVVLFGSHSIGTSHCEAFRKRLYNFTGAMDQDPSLDAGYARQLRKLCPRRHGGRGRRTKVPMDPGSGFTFDLSYYRHVLATGGLFQSDGSLLHDAATRGYVERMANASSPDEYYRDFAAAMVKMGRTDV... | 14 |
K3YT73 | 3.4.21.92 | ACT_SITE 257; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 282; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MENQVPNPKLSHLRRVRDSRFHLLLLRLVSSPPDLTLSVSHSSTLAITLSFPGRPLLPQSPTHALRPRPPPQIPRPLPERDAAAAMTPSSALALAHLAAASPLPASSPRPSPRPGSLSLGPGSAGLGPRRLVVAAPPRAFFSSSPYQPPQPEGFSPHREYGLVPMVIETTSRGERAYDIFSRLLKERIVCIHGPIADDTASLVVAQLLFLESENPLKPVHLYINSPGGVVTAGLAIYDTMQYIRCPVTTLCIGQAASMGSLLLAAGAPGERRALPNARVMIHQPSGGAQGQATDIAIQAKEILKMRDRLNKIYQKHTRQP... | 179 |
A0A022RY97 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDLKIVLAIVLFLSPFGIEGLPNGLSFDYYSKSCPQVEKIVRDAMNSKVASDPKTPAAILRLVFHDCQVGGCDGSVLLNINDKKHDAEFDSPKNFGIRNRELIDEIKTKIEKVCPQKVSCADTLVLAARDGVAIAGGPTIKVPLGRKDTTTPHTREEADKGLPRNNVDLTKALQVFFQEVGITLEEVVAIIGAHTLGKTHCDGLKERLYLNSTKLPPGNEAEFVKYLKKTCPEGGPNQFTTTLDLDPTPQSFDNKYYVNVLNGHGLISLDAEIARDPRSIDIVKKFAHDQDAFFKVFSSAFVKISTLAVLTGDKGIVRKK... | 14 |
Q5NB11 | 3.2.1.14 | ACT_SITE 114; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022" | MAKPTPAPRATPFLLAAVLSIVVVAASGAEARWYGGGGGGGYSPSPSPVSSIVSEQLYASLFLHKDDAACPARGFYTYASFVRAATRFPRFAATGCADARKREVAAFLAQISHETTGGWATAPDGPYAWGLCYKEEINPQSSYCDATDKQWPCYPGKSYHGRGPIQISWNFNYGPAGQALGFDGLRNPEIVANCSDIAFQTALWFWMTPRDTKPSCHQVMVGEYRPGPADVAANRTAGFGLVTNIVNGGLECNRAGDARVNNRIGFYRRYCQVLGVDVGPNLDCEHQQPF | 158 |
Q86HN7 | 2.7.11.1 | ACT_SITE 286; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVSINQNFKLPISMNSQPIQIQQQQFKQPQQQPQQKSNSCFSDQENYPANIQPSSSTSSSSSSSIHITKSMVIRPPLESNQPQPQQQQQQQQTLQQIHHQQVQLQQQQSLQMQQQQLQQQQQQQQQQQMPPPQSLPNKSNEPQEPIVVYETIRSGDSKRLKEYRQGEFLGKGGFAKCYLMTEVETNRIYAAKIIPKSTLQKTRARSKLKSEIKIHSSLSHENIVKFEHCFENEENVYILLELCNQKTVMDIHKKRKYLMEYETKYYVYQVIMAVQYLHNNNIIHRDLKLGNLFIDNMRIKLGDFGLSTKVEHGERKKTIC... | 99 |
A0A9R1URV8 | 6.3.4.4 | ACT_SITE 86; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 114; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 214; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MNISSVKLETNPSATAFRSLNGNVRGYTTTGLPHVSLHHHSYHRRNASIACSASPIVTLEERKGEIPSRIGSLGQVSGVLGCQWGDEGKGKLVDILAKHFDVVARCQGGANAGHTIYNSEGKKFALHLVPSGILNEETMCVIGNGVVVHLPGLFQEIDNLESNGVSCKGRILISDRAHLLFDYHQEIDGLREAELAKSFIGTTKRGIGPCYSSKVIRNGIRVCDLKHMDTFPDKLDLLLSDAASRFQGFEYSPEVLKKEVEVYKRFAERLEPFVCDTVHYMNESISQKKKVLVEGGQATMLDIDFGTYPFVTSSSPSAGG... | 253 |
I1NH45 | 1.11.1.7 | ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASISCMSAILSFLLISIFLSVYNIEVCEAQARPPTAKGLSYTFYDKSCPKLKSIVRSELKKVFNKDIAQAAGLLRLHFHDCFVQGCDGSVLLDGSASGPGEKEAPPNLTLRPEAFKIIENLRGLLEKSCGRVVSCSDITALTARDAVFLSGGPDYEIPLGRRDGLTFATRQVTLDNLPPPSSNASTILSSLATKNLDPTDVVALSGGHTIGISHCSSFTNRLYPTQDPVMDKTFGNNLRRTCPAANTDNTTVLDIRSPNTFDNKYYVDLLNRQGLFTSDQDLYTDKRTKGIVSDFAVNQNLFFEKFVFAMLKMGQLNVL... | 14 |
W1P057 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKILGLIVVAVVGLVGQCHGALQVGFYNGKCGTKDVESMVQGVVAQRFKSDNTIVAALLCLQFHDCFVSGCDASLLLDGTSSEKNAPPNLSVRGYDIINQAKAAVEAACPELVSCADIIALAARDAVSLAGGRSYAVQTGRRDALFPATNVNLPGPSISVSQAISAFKSKGLSTNDMVLLLGAHTVGVTHCPLFQNRLYNFNNTGKPDPTMNPTLASQLRTVCPNASPPQNTAVNLDQNASSAFIVDNDYYKQILSKRGILQIDQALALDSATRTSVMVLAASNPLFSIGFGNAMVKMGALQILTGTQGQVRKVCNVANG | 14 |
E9GM17 | 2.7.10.1 | ACT_SITE 699; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MAAARRSWVEESFTNFEKGINWRSYVVCDVAYNNVNNWLWTPFIERGEANRIYIEIKFSMRDCSLFPGTALSCKETFSLLYYEFDAATREPPPWEPESYKLIDRIAADEGRFTSSNEVIINTEVRSIPVTKKGVYFAFRDQGACISLLAIRVYYITCPEVTASFAAFPATPTGRELTSIEQSNGVCVANAVEDAPPKYLCKGDGNWYLQGGGCLCKPGYEANADKQTCNVCPPGKYKHRSGDDKCQTCPDHSMAPYSGSSECRCNQNYYRALKDPKSMPCTQSPSKPQNLTVNFVDQSTVVLSWNQPHNLGGRSDTVYRV... | 97 |
Q6GPK7 | 3.1.3.48 | ACT_SITE 849; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000927-1" | MNSRLRALGGRINNIRATELPKEKNRSEVVCNVRFLDGSQQCFRVNKQDTGQTLLDMAYNHLNLKEREYFGLQHNEESLDSHRWIEPSKPIRKQIKGGFPCSLLFRVRFFIPDPNTLQQDQTRHLYFLQLKSDILDGRMSCPLNSAVVLASYSVQSELGDHNPLIHVPGHLSNTSFIPGQDIDFLNKVEALHIQHSGLGQTEAESCYINIARTLEFYGIETHSGRDLHNLDLLIGIASGGIAVYKKLICSSFYPWVYILKISFKRKKFFLHQRQKQNECREQIVTFNMLSYRACKNLWRSCVEHHTFFQTRRSLPRERKV... | 149 |
A8XB52 | 2.5.1.18 | ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MTKPRIDFYFDVVSPYSWIGFEVLQKLEPKWKDVSIHYIPFSLRQVMVTSGNRPPAMLPARSIMLMLDVQRTSKFWDIPLNVPPEFKKWIMKYSTVGAMKLLLVLEKQDPDLMLRAAREMWMRLWLRSEKIFEDQDYMEVLKVVGVKNPEEIIKKSKEEKYEKILEENTNKALDTNAYGAPWINVTTSDGEEHSFFGSDRFNLIADLLGQPQPLPDKYSNSKL | 77 |
P54740 | 2.7.11.1 | ACT_SITE 130; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MARKIGSRYTAHQILGRGSAGTVWLGEGPDGPVAIKLLREDLASDQELVSRFVQERTALLGLDHPHVVSVRDLVVDGNDLALVMDLVRGTDLRTRLDRERRLAPEAAVAVVADVADGLAAAHAAGVVHRDVKPENVLLDMQGPLGPGGSHPALLTDFGVAKLIDTPRRTRATKIIGTPDYLAPEIVEGLPPRAAVDIYALATVLYELLAGFTPFGGGHPGAVLRRHVTETVVPLPGIPDELWQLLVQCLAKAPASRLRASELSARLRELLPMLAGMAPLDVDEPDAEQPEDAPDASAASPAAPVSTAEPVRRRGAVPLVP... | 99 |
B3RK08 | 3.1.3.3 | ACT_SITE 20; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 22; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MSSKEEVVQVWKAADAVCFDVDSTVCIDEGLDKLADYCGVGEQVKDLTNKAMGGTTTFREALKQRLDIFKPNQQTLQKFVEANPPQLTPGLSDVVRTLQERGTKVYLVSGGLRAIIEPVATVLNIPFENIFANRLLFFYNGEYAGFDESQPTSESGGKPRVVAHLKSLYNYKNVVMIGDGATDMEACPPADAFIGFGGNVVREKVKNGAKWFATDMAELYEALKSA | 147 |
Q00772 | 2.7.11.24 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MADKIERHTFKVFNQDFSVDKRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIKSGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETLRRIGSKNVQDYIHQLGFIPKVPFVNLYPNANSQALDLLEQMLAFDPQKRITVDEALEHPYLSI... | 104 |
A0A0R0I2R8 | 1.11.1.7 | ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MHLFMKFSSKPHFQSTIILIYQMAPLPAENILPIIFLLLIIFSVSKAELHAHYYDQTCPQVEKIISETVLKASKHDPKVPARILRMFFHDCFIRGCDASILLDSTATNQAEKDGPPNISVRSFYVIDEAKAKLELACPRTVSCADIIAISASNVVAMSGGPYWNVLKGRKDGRVSKASDTINLPAPTSNVSQLIQSFAKRGLTVKDLVTLSGGHTLGFSHCSSFEARLRNFSSLHDTDPSMNTEFALDLRKKCPKPNHNHNAGQFLDSTASVFDNDYYKQLLAGKGVFFSDQSLVGDHRTRWFVEAFVKDQSLFFKEFTA... | 14 |
P38990 | 2.7.11.1 | ACT_SITE 277; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDRSDKKVNVEEVNVPSNLQIELEKSGTSSSVSLRSPTKSSATNLAGMAEGARDNASIASSSVDSLNMLLERQRVRQLNHPQHQQHISSSLAKTPTTTSSFCSSGSSKNKVKETNRISLTYDPVSKRKVLNTYEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEKKQRKFFTFIKSSKISENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLVLEYCSRGEVKWCPPDCMESDAKGPSLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGVSLAASSTNSSDSSESLDELELA... | 99 |
I1HM78 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRSPWLVLAAAALAVSVSSVTAYPPPSNSLKVGFYEHSCPQAEAIVRDAVRRAIARNPGFAPGLIRMHFHDCFVRGCDGSVLINSTPGNRAEKDSVANTPSLRGFEVIDDAKAILESVCPRTVSCADILAFAARDSTLLAGDIAYAVPSGRRDGLVSRESEVLDNNVPPPTDEVGALIASFARKGLSADDMVTLSGAHTIGRSHCSSFTQRLHNFTGVRGRTDPSIEPYYAAELKRRCPPETNDMNNPTVVPLDVVTPVQFDNQYFKNVLAHKVPLTSDQTLLTCKRTAGIVVFHAAVEKAWRAKFAVSMVRMGNVGVLT... | 14 |
A2E273 | 3.5.1.98 | ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MKKKNIVYLYDEESGGFVYERSHPMKPYRIKMTHSLLCAYGLLDKLQVLTPRRARVEDLIQFHDEGYINFIKNSNDKNISKNRNAAEYYNITGDSPFFPGLFEFCQISAGASITAAELLNSGKTQIAINWAGGLHHARKAEASGFCYVNDCVLGILKLLERYQRVLYIDIDIHHGDGVEEAFYTTDRVFTVSFHKFGDFFPGTGALSDIGTRKGKYYALNVPLRDGMNDEDYLGLFKPILTNIIEWYRPNAIFFQCGADSLAGDKLGGFNLSIHGHGECVRFVKNFGIPMVVAGGGGYTTRNVSRCWTYETAILLDEVLD... | 184 |
Q43731 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297" | MVVVNKTNLLLLLLSLCLTLDLSSAQLRRNFYAGSCPNVEQIVRNAVQKKVQQTFTTIPATLRLYFHDCFVNGCDASVMIASTNNNKAEKDHEENLSLAGDGFDTVIKAKEALDAVPNCRNKVSCADILTMATRDVVNLAGGPQYDVELGRLDGLSSTAASVGGKLPHPTDDVNKLTSLFAKNGLSLNDMIALSGAHTLGFAHCTKVFNRIYTFNKTTKVDPTVNKDYVTELKASCPRNIDPRVAINMDPTTPRQFDNVYYKNLQQGKGLFTSDQVLFTDRRSKPTVDLWANNGQLFNQAFINSMIKLGRVGVKTGSNGN... | 14 |
Q9LJD8 | 2.7.11.1 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MARQMTSSQFHKSKTLDNKYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIVQEDLNTIMQEIDLLKNLNHKNIVKYLGSSKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLNEADVNTHSVVGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDDNPPIPDSLSPDITDFLRQCFKKDSRQRPDAKTLLSHPWIRNSRRALQSSLRHSGTIKYMKEATASSEKDDEGSQDAAESLSGENV... | 99 |
A0A251VCT5 | 2.7.11.1 | ACT_SITE 310; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 327; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MSIANETPAIEQATNENEDPEPLEDETDDDEELSWSSDSEIGEALDYLDLKDDAGAVDGALVLNARRPNAHGGVHSRPNASALQPLSNRNQKFTNHIRASPLEEWEGRWNRGMSNSVTTAIRESVRGMAIGKTKTTEKADRATVEQAIDPRTRMVLFKMLNRGVFHDINGCISTGKEANVYHATKSDGQELAIKVYKTSVLVFKDRDRYVQGDYRFRHGYCKHNPRKMVKTWAEKEMRNLMRLKAAGIRCPTPLLLRLHVLVMEFIGTTGWAAPRLKDAALSLDKLREGYVEMITSMRVLYQKCKLVHGDLSEYNILYHE... | 99 |
Q89Z05 | 4.2.1.11 | ACT_SITE 204; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 340; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MKIEKIVAREILDSRGNPTVEVDVVLESGIMGRASVPSGASTGEHEALELRDGDKQRYGGKGVQKAVDNVNKIIAPKLIGMSSLNQRGIDYAMLALDGTKTKSNLGANAILGVSLAVAKAAASYLDLPLYRYIGGTNTYVMPVPMMNIINGGSHSDAPIAFQEFMIRPVGAPSFREGLRMGAEVFHALKKVLKDRGLSTAVGDEGGFAPNLEGTEDALNSIIAAIKAAGYEPGKDVMIGMDCASSEFYHDGIYDYTKFEGAKGKKRTAEEQIDYLEELINKFPIDSIEDGMSENDWEGWKKLTERIGDRCQLVGDDLFVT... | 200 |
P0DOY1 | 2.1.1.37 | ACT_SITE 538; /evidence="ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018, ECO:0000269|PubMed:27856912" | MRGGSRHLSNEEDVSGCEDCIIISGTCSDQSSDPKTVPLTQVLEAVCTVENRGCRTSSQPSKRKASSLISYVQDLTGDGDEDRDGEVGGSSGSGTPVMPQLFCETRIPSKTPAPLSWQANTSASTPWLSPASPYPIIDLTDEDVIPQSISTPSVDWSQDSHQEGMDTTQVDAESRDGGNIEYQVSADKLLLSQSCILAAFYKLVPYRESIYRTLEKARVRAGKACPSSPGESLEDQLKPMLEWAHGGFKPTGIEGLKPNKKQPENKSRRRTTNDPAASESSPPKRLKTNSYGGKDRGEDEESREQMASDVTNNKGNLEDH... | 47 |
D8RBW3 | 1.1.1.37 | ACT_SITE 194; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MSSVPGGKPLPVRKPLPYRRVTVLGAAGGIGQPLSMLLKLNPLVSKLSLYDIAGTPGVATDLSHINTRTEVHGFAGDDQLKDALKDADLVIIPAGVPRKPGMTRDELFDINAGIVKKLVQAIAKHCPFALINMISNPVNSTVPIAAEVLKVEGTYDHTRLFGVTTLDVVRARTFYAKAKNLPIEDVDVPVVGGHAGKTILPLFSQATPQVPLSKEEVEELTRKTQDGGTEVVQAKAGKGSATLSMAYAAALFAESCLKAMNGEPNIIECAYVGSSVTDYPFFASKVELGKHGMVKALELGPISKYEQTCLDEMKDELMGS... | 5 |
A0A7M7N324 | 3.2.1.17 | ACT_SITE 44; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR608597-1"; ACT_SITE 57; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR608597-1" | MAVVITNVLIFCAVFVAALGTEKYHVALPTPVPADCLRCICIVESKCKMPAHVCHMDVGSLSCGPYQIKDDYWNDARMKGGDLMGSWRKCTADMGCSGETVQGYMARYAVFSRLEHQPTCEDFARIHNGGPNGYNRTSTLKYWSKVEECLNGRKWDFN | 160 |
A8WXF6 | 2.7.11.17 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MMNACTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDTVDCLKKFNARRKLKAAISAVKMVTRMSGVLRTSDST... | 101 |
A7S1S6 | 2.4.1.18 | ACT_SITE 338; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 393; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MSVVPELSKFLHDDPYIQPYVQEIERRYKCFKSIKTDIQNHEGGLEPFSRGYEKFGINRTASGGQVYREWAPGAHGVFLIGDFNGWNRTSHPCKRNEYGVWELEIPCLDNGSLSIPHGSKVKVGIQLQSGEIVDRISPWIRYAAPPQDETNTVYEGINWDPPNPYQFKHTRPKRPKSLRVYEAHVGIASNEPKVASYQHFAEVVIPKVHGLGYNCIQLMAVMEHAYYACFGYQVTSFFAASSRYGTPDELRLLIDTAHSYGIVVLLDIVHSHAAKNVMDGLNQFDGTEGCYFHSGGRGTHSLWDSRLFDYTQWEVLRFLL... | 73 |
A0A067GSJ9 | 3.1.1.11 | ACT_SITE 188; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRPVLKSLIVFTLLSTISFRAARADQDCKGSNVAYTVTVDQSSSQYRTVQSAIDSIPAENNQWIKVHIKAGTYKEKVKIQRNKPCILLEGEGSGVTKITYDDHQSTDTSATFSSFADNVVAKGITFEVEGRDLGTLQAGNDITQALAARIYGDKSAFYDCRFLGVQDTLWDVQGRHFFKSCYIEGAIDFIFGNGQSVYEDCSVNSTAGLLIGGRGSGYITAQSRGSANDPGGFVFRGGEVTGTGQAYLGRAYGPYSRVIFYNAWLSSVVTPPGWNAWNLQGQEGNFMYAEVNCKGPGSDTSNRVSWEKKIDPKLLYKYST... | 125 |
A0A803TWR8 | 2.7.11.1 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSEMQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVAAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQPLNRTLAIELLDKMNNPDHSTYHDFDDDDPEPLLVLHRIHSTSRNVREEKTRSEINFGQVKFDPPLRKETEPHHEFPDSNDFLDSSEEIYYTARSNLDLQLEYGQGPQ... | 99 |
A0A251T2S3 | 3.4.21.89 | ACT_SITE 49; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 93; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MKPLLNNLTKWSAIAKQSFDRAAIVAKFLCLLHVTNTYIFSPTLVYGPSMLPTLNLTGDVLLSEYVSHRLGKVGPGDVVLIQSPENPRKMITKRVVAMEGETVSFLVEPSRSDRSRTVVVPKGHVWIQGDNIYASNDSRNFGPIPYGLIQGKVWCRVWPLDGFGSL | 178 |
Q9VLR3 | 3.5.4.5 | ACT_SITE 77; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MTQVFINGARDDLNVREFQSLDPSIQEIILAATEARKQAYCPYSNFAVGAALRTSDGTIYSGCNIENGAYATCICAERTAAVKAISEGKRDFVACAVVAQQDNGFTTPCGVCRQFLSEFVNGKDIPLYAAKPTNLPLRVLCTSVLQLLPNGFSFANGK | 187 |
P52484 | 2.3.2.23 | ACT_SITE 106; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MSVSKLNKMQFSDKMSNLALARVTRKCKEVANASDITEAGIHVEIKENNLMDIKGFIKGPEGTPYAGGTFEIKVDIPEHYPFEPPKAKFVTRIWHPNISSQTGTICLDILKDKWTASLTLRTVLLSLQAMLCSPEPSDPQDAVVAKQFINNYPMFTATAVYWTSYFANSKKDVEPDFNRKVGRLIEMGIRETEAIVYLSCNNWKLEQALQFIFD | 64 |
Q9NVE5 | 3.4.19.12 | ACT_SITE 50; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 305; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MFGDLFEEEYSTVSNNQYGKGKKLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTADLTDSFGWTSNEEMRQHDVQELNRILFSALETSLVGTSGHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQ... | 175 |
A0A078H6W8 | 3.1.1.11 | ACT_SITE 249; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPIKPVVTTVIAIFFTILALYTIPLPSSLSSIATTIITNPQLEPLSIYSTFFGHRHHHHHHHHHHHHHHHNRVPIKCCEKWTSKLTHLYKTSLVLTVDLNGCGNFSNVQSAIDSVPDLSPSKTLIIVNSGVYSREKVTVNENKTNVVMQGRGYQNTSIEWNDTAKSAGGTAYSFSFAVLAANFTAYNISFKNNAPEPDPGEDDAQAVALKIEGDQCAFYGCGFYGAQDTLLDDRGRHFFKNCFIQGSIDFIFGNGRSLYQDCTINSIAKENTSGVSGSITAHGRQSEDEQTGFSFVNCKIDGSGNMWLGRAWGAYATVVF... | 125 |
Q5B7X2 | 3.2.1.78 | ACT_SITE 211; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q99036"; ACT_SITE 312; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q99036" | MKFSQALLSLASLALAAALPHASTPVYTPSTTPSPTPTPSASGSFATTSGIQFVIDGEAGYFPGSNAYWIGFLKNNSDVDLVFDHMASSGLRILRVWGFNDVNTAPTDGSVYFQLHQDGKSTINTGKDGLQRLDYVVHSAEKHGIKLIINFVNYWDDYGGMNAYMRAYGGGDKADWFENEGIQAAYQAYVEAVVKRYINSTAVFAWELANEPRCTGCEPSVLHNWIEKTSAFIKGLDEKHLVCIGDGSDGSYPFQYTEGSDFAAALTIDTIDFGTFHLYPDSWGTNNDWGKLWITSHAAACAAAGKPCLFEEYGVTSNHC... | 172 |
P47343 | 3.2.2.27 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000250" | MVMDDLFQRMVSCVLPSWRAFIDEEVKKPYFQALLEKLKALKATIIPKPELIFRVFSFFKPIDTKVIIFGQDPYPSPNDACGLAFASNNSKTPASLKRIILRLEKEYPSLKQESSWQQNFLLNWAEQGVLLLNGILTTTVFIRNAHKNWGWEEFNCNLLTFLKNQNIKPLLVFLGVQTKNFVVKSIGNVDGFEHLSYPHPSPLSGNLFLTNPNDLFKTINNWLKQHNQKIINWAVVKNASFDQLS | 173 |
A0A337RZA8 | 3.2.1.35 | ACT_SITE 129; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MIMQLGLALVLGMALCLGCGQPLLWAPERPFSVLWNIPSAHCKTRFGVHLPLEALGITANRGQRFHGQNITIFYKNQLGFYPYLGPRGTAHNGGIPQVVPLDRHLARAACQIHLSLERGFAGLAVLDWEEWCPLWAGNWGRRRAYQEASWAWAQRVFPHLNPQEQLHKARAGFEQAARALMEDTLRLGQALKPHGFWGFYRFPACGNGWHGTAFNYTGHCHPATLARNTQLHWLWAASSALFPSIYLPPKLPPIHHQAFVRYRLEEAFRVALVGHPHPLPVLAYARLTYRHSGRFLSQDDLVQTIGVTAALGAAGVVLWG... | 166 |
A8XFY3 | 2.7.11.1 | ACT_SITE 228; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 586; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MGLQRGMPLAQLGEPFGITPAAIENVSPGIDQCKDHRIDASMRSEPSDYFSDTTNTFHSSIHVVHPTINNGTRMNKKESSASETEIDIGDVRKCGEKADRQQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKIRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMNQILKAKL... | 99 |
P53598 | 6.2.1.5 | ACT_SITE 284; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_03222" | MLRSTVSKASLKICRHFHRESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFASVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNCPGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDFIDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMGHSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQA... | 247 |
Q814C2 | 5.4.99.12 | ACT_SITE 53; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MDRIKCTVAYDGMHFCGYQIQPNHRTVQQEIEKALQKLHKGELVRVQASGRTDSTVHAKGQVIHFDTPLSLEEWQWSNALNTMLPDDIVIRQVEKKTEEFHARYGVEKKEYRYRVLLSKTADVFRRNYVYQYPYPLEINSIRKAIPYFIGTHDFTSFCSAKTDKKDKVRTIYEIELIEQDDEIIFRFVGNGFLYNMVRIIVGTLLSVGQGKLDPDSIPEILAKQNRQFAGKMAPGHGLYLWEVNYNN | 217 |
A0A1U8LH68 | 3.1.1.11 | ACT_SITE 396; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MANNAIIGICAVFLVALVVAVVVGVTHIKNKSDGEEISSSNKAVQALCQPTNYKETCQKSLASSNSSDVKELIRTGFQAGLVEIKNVLAHSVTVQELIKDENNKAALGVCQEVLDLAIDDFQKSFDMLGEYDMSKIGKYLLELKTWLSGAFTSQQTCIDSFAESSNESSQKMQSILKTSMEITSNALAMLNGLSTIVKELNIPNVGNIDTTGVNRKLLSAEDMPEWISQADRKLLQAKPMDLKPNVVVAKDGSGKYDTINKALAEVPVKSPDRFVIHIKAGTYKEQINVTKQMTNVVFIGDGPTKTIITNDISVAKNPPV... | 125 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.