query stringlengths 17 395 | pos list | neg list | task stringclasses 1
value | instruction dict |
|---|---|---|---|---|
Does modulation of cellular proliferation alter glutamine transport and metabolism in human hepatoma cells? | [
"The authors determined the effects of growth inhibition on glutamine transport and metabolism in human hepatoma cells. Hepatoma cells exhibit markedly higher (10- to 30-fold) glutamine uptake than normal human hepatocytes, via a disparate transporter protein with a higher affinity for glutamine. Currently, little ... | [
"The sodium-glucose transporter 2 (SGLT2) inhibitors Canagliflozin and Dapagliflozin are recently approved medications for type 2 diabetes. Recent studies indicate that SGLT2 inhibitors may inhibit the growth of some cancer cells but the mechanism(s) remain unclear. Cellular proliferation and clonogenic survival we... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do long-term kidney isografts develop functional and morphologic changes that mimic those of chronic allograft rejection? | [
"This study examined antigen-independent factors in the pathogenesis of chronic rejection of organ transplants. In addition to alloantigen-dependent events, antigen-independent factors can influence chronic rejection of organ allografts. Initial injury, including early ischemia and acute rejection, may contribute. ... | [
"Apart from their important role in mediating calcium homeostasis, vitamin D derivatives regulate numerous vitamin D receptor-mediated renoprotective cellular functions including cell differentiation, negative regulation of inflammation, and fibrosis. Renal models of chronic kidney injury and clinical observational... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does bacteriuria in patients with a continent ileal reservoir for urinary diversion regularly require antibiotic treatment? | [
"To elucidate the importance of bacteriuria in patients with a continent urinary diversion. Eighteen asymptomatic patients (16 women and two men, with a mean age of 53 years [range 22-73]) with ileal reservoirs coupled to the skin for urinary diversion were studied. Consecutive urine cultures were performed over 5 ... | [
"Combined pancreas-kidney transplantation is the treatment of choice for patients with type I diabetes mellitus associated with chronic renal failure. The introduction of the bladder drainage technique constituted a marked improvement of the surgical technique with a reduction of life-threatening complications. How... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is magnesium more efficacious than phenytoin in reducing N-methyl-D-aspartate seizures in rats? | [
"Although magnesium sulfate is one of the most commonly used agents for seizure prophylaxis in preeclampsia, its efficacy relative to other anticonvulsants is incompletely investigated. The underlying mechanisms of eclamptic seizures are unknown, and there is currently no universally accepted animal model for eclam... | [
"Spreading depolarizations, characterized by large propagating, slow potential changes, have been demonstrated with electrocorticography in patients with cerebral hemorrhage and ischemic stroke. Whereas spreading depolarizations are harmless under normal conditions in animals, they cause or augment damage in the is... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is immunoreactive tumor necrosis factor-alpha elevated in maternal plasma but undetected in amniotic fluid in the second trimester? | [
"We investigated the participation of the cellular arm of the immune system in adaptation to pregnancy by assessing plasma and amniotic fluid levels of the cytokine tumor necrosis factor-alpha. Fifty-five healthy pregnant women who underwent second-trimester genetic amniocentesis at a mean gestational age of 17.0 +... | [
"Polyhydramnios places increased tension on the fetal membranes and should conceptually be associated with an increased need for tissue remodeling to prevent premature rupture of membranes (PROM). Herein we use polyhydramnios as a model to study the association of the collagenase class of matrix metalloproteinases ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does starvation induce differential small bowel luminal amino acid transport? | [
"The importance of small intestinal mucosa functions has been emphasized in recent years because gut metabolism becomes better defined. One of the major activities of the enterocyte is amino acid transport, which is important not only for the organism but also for the integrity of the mucosa. Bowel rest during the ... | [
"To assess the direct effects of ischemia on intestinal epithelial integrity. Furthermore, clinical efforts at mitigating the effect of hypoperfusion on gut permeability have focused on restoring gut vascular function. We report that, in the Caco-2 cell model of transepithelial transport, calcium glycerophosphate (... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does monoclonal immunoglobulin A prevent adherence and invasion of polarized epithelial cell monolayers by Salmonella typhimurium? | [
"Invasion of the intestinal epithelium is considered a critical step in Salmonella pathogenesis. Infection by Salmonella of cultured monolayers of polarized Madin-Darby canine kidney (MDCK) cells has been established as a simple in vitro system that mimics the invasion of intestinal enterocytes in vivo. This study ... | [
"Enterotoxigenic Bacteroides fragilis has been associated with diarrheal disease, and the enterotoxin has a cytopathic effect on cultured HT-29 enterocytes. Experiments were designed to determine the effect of B. fragilis enterotoxin on bacteria-enterocyte interactions. Confluent HT-29 enterocytes were incubated fo... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does transient posterior localization of a kinesin fusion protein reflect anteroposterior polarity of the Drosophila oocyte? | [
"During oogenesis in Drosophila, determinants that will dictate abdomen and germline formation are localized to the 'polar plasm' in the posterior of the oocyte. Assembly of the polar plasm involves the sequential localization of several messenger RNAs and proteins to the posterior of the oocyte, beginning with the... | [
"During brain development, neurons migrate from germinal zones to their final positions to assemble neural circuits. A unique saltatory cadence involving cyclical organelle movement (e.g., centrosome motility) and leading-process actomyosin enrichment prior to nucleokinesis organizes neuronal migration. While funct... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does escherichia coli heat-stable enterotoxin-mediated colonic Cl- secretion is absent in cystic fibrosis? | [
"Calcium- and adenosine 3',5'-cyclic monophosphate (cAMP)-mediated Cl- secretions in the human colon are abnormal in cystic fibrosis, but the effect of guanosine 3',5'-cyclic monophosphate (cGMP) is unknown. This study examined the effects of the cGMP activator Escherichia coli heat-stable enterotoxin (STa) on rect... | [
"Attaching and effacing Escherichia coli demonstrate marked species specificity in inducing diarrhea, although its mechanism remains largely unclear. The purpose of this study was to investigate the existence of a soluble, species-specific factor that induces diarrhea in an in vitro model. Stripped rabbit ileum was... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does active compression-decompression CPR improve vital organ perfusion in a dog model of ventricular fibrillation? | [
"This study was designed to assess whether a new method of cardiopulmonary resuscitation (CPR), termed active compression-decompression CPR, or ACD-CPR, improves organ perfusion when compared with standard (S) CPR in a dog model of ventricular fibrillation. ACD-CPR has recently been shown to improve hemodynamic and... | [
"Most out-of-hospital ventricular fibrillation (VF) is prolonged (>5 minutes), and defibrillation from prolonged VF typically results in asystole or pulseless electrical activity. Recent visual epicardial observations in an open-chest, open-pericardium model of swine VF indicate that blood flows from the high-press... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is transvaginal ultrasonographic evaluation of the cervix before labor : presence of cervical wedging associated with shorter duration of induced labor? | [
"Our purpose was to test the hypothesis that transvaginal ultrasonographically determined characteristics of the cervix are associated with duration of induced labor. Fifty-three patients scheduled for induction of labor underwent transvaginal ultrasonography and digital cervical examinations before labor induction... | [
"Relaxation of pelvic ligaments may facilitate parturition in certain animal species. Biomechanical properties of pelvic connective tissue may also influence progress of labour in the human female. This study was designed to test whether peripheral joint mobility or pelvic organ mobility as measures of connective t... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are increased interleukin-6 concentrations in cervical secretions associated with preterm delivery? | [
"This study sought to determine whether elevated concentrations of interleukin-6 in the cervical and vaginal secretions of patients between 24 and 36 weeks' gestation predicted subsequent preterm delivery and/or identified those preterm deliveries associated with maternal infectious morbidity. A cohort study was un... | [
"To compare cervical concentrations of numerous cytokines/chemokines in women with bacterial vaginosis (BV) compared with the levels detected after BV resolution and determine if hormonal contraceptive use modulates the local inflammatory response to BV. Cervical secretions from 81 women with BV at enrollment and n... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are low doses of interferon-alpha as effective as higher doses in inducing remissions and prolonging survival in chronic myeloid leukemia? | [
"To determine the toxicity and efficacy of low-dose interferon-alpha therapy in inducing remissions and prolonging survival in patients with chronic myeloid leukemia. Phase II evaluation and comparison with historical control patients and other series in which the investigators used higher interferon-alpha doses. T... | [
"Pemphigus vulgaris is a potentially life-threatening autoimmune disease. Although combination therapies with prednisone and azathioprine are usually effective in controlling the disease, some patients either do not respond to this treatment or show early relapses. To find out whether mycophenolate mofetil would be... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does insulin-like growth factor-I promote successful fetal pancreas transplantation in the intramuscular site? | [
"Fetal pancreas (FP) has the capacity for exuberant proliferation and engrafts in the safe, accessible intramuscular site. These characteristics make FP transplantation an attractive approach to the treatment of diabetes mellitus. Insulin-like growth factor-I (IGF-I) is an important mediator of growth and maturatio... | [
"The aim of this study was to assess the effect postoperative enteral nutrition support on the survival after orthotopic small bowel transplantation in mice. A model of orthotopic small bowel transplantation used C57BL/6 mice as both donors and recipients. We demonstrated that postoperative ileus was the deciding c... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do psychiatric disorders in and service use by young homeless people? | [
"To examine psychiatric morbidity, including substance use disorders, and service use in young people with experience of homelessness. A cross-sectional study of 34 new residents in a supported accommodation program in Melbourne. Current and lifetime psychiatric diagnoses were made using the Structured Clinical Int... | [
"Utilization of the Recovery Knowledge Inventory (RKI) and Recovery Attitudes Questionnaire (RAQ) in southeastern Australia raised questions about the RAQ, including links between attitudes, faith, and culture in supporting the recovery journey. These questions are particularly important when considered in the cont... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does soluble CD23 reliably reflect disease activity in B-cell chronic lymphocytic leukemia? | [
"This study was initiated to evaluate whether soluble CD23 (sCD23) reflects disease activity and tumor load in B-cell chronic lymphocytic leukemia (B-CLL) and to determine its prognostic potential for this disease. The concentration of sCD23 was measured in the serum of 45 B-CLL patients, 50 patients with other lym... | [
"A model of a stepwise malignant transformation has been proposed for the pathogenesis of monoclonal gammopathies. In this model, cell cycle regulators play a central role as a source of genetic events; particularly, p16/INK4a gene acts as a tumoral suppressor gene and, recently, inactivation of this gene through a... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is [ Thoracic epidural anesthesia by the caudal route in pediatric anesthesia : age a limiting factor ]? | [
"To evaluate the success and degree of difficulty of inserting an epidural catheter into the caudal space in order to place its distal end at T10 in young patients. Forty-seven children up to 97 months old were studied. With the patients under general anesthesia with an orotracheal tube, a predetermined length of 1... | [
"Some anesthesiologists consider combined spinal epidural (CSE) analgesia as superior alternative to continuous labor epidural (CLE) analgesia. However, during CSE, even small doses of intrathecally administered local anesthetics with opioids induce almost instant analgesia that precludes the testing of epidural ca... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are serum level of squamous cell carcinoma antigen and tumor size useful to identify preoperatively patients at high risk of cervical cancer? | [
"The benefit of postoperative adjuvant therapy for patients with cervical cancer is uncertain, and moreover, may increase morbidity. In this study, patient age, clinical stage of the cancer, tumor size, and levels of serum squamous cell carcinoma cell antigen and carcinoembryonic antigen were studied in patients wi... | [
"The appearance of distant metastasis is a fatal sign in patients with soft tissue sarcoma. Therefore, we studied the risk factors associated with distant metastasis that appear in malignant fibrous histiocytoma. The study group comprised sixty patients treated for malignant fibrous histiocytoma at our hospital bet... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is the rate of increase in blood pressure in children 5 years of age related to changes in aerobic fitness and body mass index? | [
"To determine whether changes in aerobic fitness and body mass index are related to the age-related rise in blood pressure in healthy preschool children. Longitudinal analyses of 196 free-living children aged 5 years at baseline who were followed over a mean of 19.7 months. Aerobic fitness was assessed using a trea... | [
"The results of several recent research studies have questioned the benefit of chronic running in reducing the risk of developing osteoporosis. These negative conclusions are based upon the findings that runners, in general, are not different from controls with regard to their bone mineral density (BMD). This has l... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are tobacco industry campaign contributions affecting tobacco control policymaking in California? | [
"To test the hypothesis that tobacco industry campaign contributions are influencing the behavior of members of the California legislature. Multivariate simultaneous-equations regression was used to analyze data on campaign contributions from the tobacco industry to members of the California legislature in 1991 and... | [
"To identify and examine the strategies utilised by multinational tobacco companies to undermine and discredit key anti-tobacco activists and organisations in the Asian region. A series of case studies drawing upon material gathered through systematic reviews of internal tobacco industry documents. Tobacco industry... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does chloroquine enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages? | [
"Chloroquine, an alkalinizing lysosomotropic agent, enhances the intracellular activity of antibiotics against Mycobacterium tuberculosis or Coxiella burnetii. To determine if chloroquine modifies the activity of clarithromycin, less effective at acidic pH, against intracellular Mycobacterium avium. The activity of... | [
"With the worldwide emergence of highly drug-resistant tuberculosis (TB), novel agents that have direct antimycobacterial effects or that enhance host immunity are urgently needed. Curcumin is a polyphenol responsible for the bright yellow-orange colour of turmeric, a spice derived from the root of the perennial he... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is hyperoxic reperfusion required to reduce infarct size after intravenous therapy with perfluorochemical ( Fluosol-DA 20 % ) or its detergent component ( poloxamer 188 ) in a poorly collateralized animal model . Absence of a role of polymorphonuclear leukocytes? | [
"The aim of this study was to assess whether hyperoxic reperfusion contributes to the efficacy of Fluosol 20% or poloxamer 188 for infarct size reduction and whether suppression of polymorphonuclear leukocyte function is responsible for cardioprotection. The perfluorochemical Fluosol and its detergent component pol... | [
"The purpose of this study was to investigate whether liposomal adenosine has stronger cardioprotective effects and fewer side effects than free adenosine. Liposomes are nanoparticles that can deliver various agents to target tissues and delay degradation of these agents. Liposomes coated with polyethylene glycol (... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do volatile anesthetic agents inhibit choline uptake into rat synaptosomes? | [
"Acetylcholine is an excitatory neurotransmitter associated with the maintenance of consciousness. Choline uptake is the rate-limiting step in acetylcholine synthesis and may be a target for the action of volatile anesthetic agents. [Methyl-3H]choline uptake was investigated using rat cortical synaptosomes. The pre... | [
"To determine the effect of the ketone bodies beta-hydroxybutyrate (betaHB) and acetoacetate (AA) on excitatory and inhibitory neurotransmission in the mammalian CNS. The ketogenic diet is presumed to be an effective anticonvulsant regimen for some children with medically intractable seizures. However, its mechanis... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are psoriasis and eczema mutually exclusive diseases? | [
"Some reports have suggested that psoriasis and eczema are seldom found together. Knowledge of disease co-occurrence could lead to improved understanding of shared or opposing pathological mechanisms. We sought to determine whether psoriasis and eczema could exist simultaneously and consecutively in the same indivi... | [
"Do platelets play any role in the development of endometriosis?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is ultrasonographic examination of the uterine cervix better than cervical digital examination as a predictor of the likelihood of premature delivery in patients with preterm labor and intact membranes? | [
"The purpose of this study was to compare the diagnostic performance of ultrasonographic and digital examination of the cervix in the prediction of preterm delivery in patients presenting with preterm labor and intact membranes. Endovaginal ultrasonography was performed in 59 patients admitted with preterm labor (2... | [
"Preterm birth is a leading cause of perinatal mortality and morbidity. Heavy cervicovaginal Ureaplasma colonization is thought to play a role in the pathogenesis of preterm birth. The administration of vaginal progesterone has been shown to reduce the incidence of preterm birth in women with short cervical length.... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does amniotic fluid volume reflect recent glycemic status in gestational diabetes mellitus? | [
"Our purpose was to determine the association between amniotic fluid volume and recent glucose status in gestational diabetes. Serial amniotic fluid index values, mean blood glucose levels, and percent hyperglycemia (> or = 120 mg/dl) 1 day and 1 week before the ultrasonographic examinations were prospectively coll... | [
"N-terminal-pro-brain natriuretic peptide (NT-proBNP) is elevated in gestational hypertension and preeclampsia. This trial aimed to generate data for gestational diabetes mellitus patients, who are at risk to develop these complications. We have measured NT-proBNP in 223 otherwise healthy women between gestational ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does nonpharmacologic therapy improve functional and emotional status in congestive heart failure? | [
"To compare the effects of a multimodal nonpharmacologic intervention to digoxin and to placebo in patients with congestive heart failure receiving background therapy with angiotensin-converting enzyme inhibitors. Randomized, parallel assignment to three treatment groups of 20 patients with congestive heart failure... | [
"to present clinical guidelines for exercise therapy in depressed patients derived from recent meta-analyses. four meta-analyses on effects of physical exercise on mental and physical in depression were analysed. For mild to moderate depression the effect of exercise may be comparable to antidepressant medication a... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does pEEP ventilation cause humorally mediated cardiac output depression in pigs? | [
"This study was designed to see if humorally mediated negative inotropism contributes to the cardiac output (CO) depression seen during positive end-expiratory pressure (PEEP) ventilation. 8 pairs of piglets were used and a combined blood circulation was established between the two animals in each pair. One animal ... | [
"Mechanical ventilation (MV) is commonly used to improve blood oxygenation in critically ill patients and for general anesthesia. Yet the cyclic mechanical stress induced at even moderate ventilation volume settings [tidal volume (Vt) <10 mL/kg] can injure the lungs and induce an inflammatory response. This work ex... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do rat renal preglomerular vessels , glomeruli and papillae express detectable quantities of B-type natriuretic peptide receptor? | [
"Atrial natriuretic factor (ANF) receptor subtypes were quantitated by radioligand studies in three different rat renal isolated tissues: preglomerular vessels, glomeruli and papillae. In preglomerular vessels 100% of [125I]-ANF binding was displaced with high affinity by ANF. C-ANF (des-[Gln18,Ser19,Gly20,Leu21,Gl... | [
"Within 24h four cardiac hormones, i.e., vessel dilator, kaliuretic peptide, atrial natriuretic peptide, and long acting natriuretic peptide decrease the number of human glioblastoma cells 75%, 68%, 67%, and 65% while Dendroaspis (green mamba) peptide caused a 17% decrease when each were utilized at 100 microM. The... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does crystal structure of Vibrio cholerae neuraminidase reveal dual lectin-like domains in addition to the catalytic domain? | [
"Vibrio cholerae neuraminidase is part of a mucinase complex which may function in pathogenesis by degrading the mucin layer of the gastrointestinal tract. The neuraminidase, which has been the target of extensive inhibitor studies, plays a subtle role in the pathology of the bacterium, by processing higher order g... | [
"The complex polysaccharide rhamnogalacturonan constitutes a major part of the hairy region of pectin. It can have different types of carbohydrate sidechains attached to the rhamnose residues in the backbone of alternating rhamnose and galacturonic acid residues; the galacturonic acid residues can be methylated or ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is constipation a risk factor for hemorrhoids : a case-control study of potential etiological agents? | [
"Constipation is widely believed to cause hemorrhoids. However, recent evidence questions the importance of constipation in the development of this common disorder. In the present study, the association of hemorrhoids with constipation and other potential risk factors was examined. The analysis consisted of 325 con... | [
"Aspirin is considered one of the most prescribed drugs worldwide, predominantly for its cardioprotective effects. However, its use may be precluded by gastrointestinal and haematological side-effects. To investigate the association between the prophylactic use of aspirin and the prevalence of anaemia among adults.... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does magnetic resonance imaging show gadolinium enhancement of intradural herniated disc? | [
"A patient with a herniated intradural disc at L2-L3 and an extradural herniated disc at L5-S1 had homogeneous enhancement of the intradural disc on magnetic resonance imaging. The only prior report of intradural disc enhancement with contrast on magnetic resonance imaging showed nonhomogeneous peripheral or ring e... | [
"Neurocysticercosis is a major public health concern. Although its eradication appears feasible, the disease remains endemic in developing countries and has emerged again in Europe and in the USA. Basic studies on neurocysticercosis are needed to better understand the pathophysiologic mechanisms and, consequently, ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is sexual communication associated with condom use by sexually active incarcerated adolescents? | [
"Incarcerated adolescents are at increased risk for infection by sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV). Moreover, condom use by this population is extremely low. Although interpersonal variables such as sexual communication have been found to be associated with condom us... | [
"To determine the prevalence and correlates of Chlamydia trachomatis in Canadian street youth. A cross-sectional study of street youth between the ages of 15-24 years was conducted over a 9-month period in seven large urban centers across Canada. Youth were recruited through \"drop-in\" centers, outreach work, and ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do gastric emptying rates to liquid or solid meals appear to be unaffected by spinal cord injury? | [
"There is controversy with regard to the effect of spinal cord injury (SCI) on gastric emptying times of liquids. The emptying rates of solids in subjects with SCI have not yet been addressed. Thus, the gastric emptying rates for both liquids and solids were studied by radionuclide imaging in subjects with chronic ... | [
"Oleic acid premeal supplements have been described as a method to trigger the ileal brake and thus lengthen transit time and the opportunity for nutrient absorption. The aims of this study were to determine whether oleic acid supplements would lengthen transit time and improve absorption of nutrients in study part... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are hematopoietic progenitor cells resistant to dimethyl sulfoxide toxicity? | [
"A direct chemical toxicity of dimethyl sulfoxide (DMSO) to hematopoietic progenitor cells has been suggested. However, a recent study failed to corroborate these earlier findings. Thus, a series of experiments was undertaken to address this issue. Bone marrow was collected from 18 donors and cryopreserved with 10 ... | [
"Retinoids are candidate differentiation-inducing agents for glial tumors. Differentiation therapy is an attractive approach to cancers that resist surgery, irradiation and chemotherapy. We examined the effects of retinoids on proliferation, morphology and sensitivity to apoptosis in human malignant glioma and neur... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does danazol influence gonadotropin secretion acting at the hypothalamic level? | [
"The purpose of the study was to determine the influence of danazol on gonadotropin secretion. Ten endometriotic patients were treated with danazol for 6 months. To evaluate gonadotropin and estradiol secretion, a gonadotropin-releasing hormone (GnRH) test and a clomiphene citrate (CC) challenge test were carried o... | [
"Drospirenone is the unique progestin derived from 17-spironolactone used for contraception and hormone therapy. Few data are available concerning the effects of drospirenone on the central nervous system and neuroendocrine milieu. The opioid beta-endorphin and the neurosteroid allopregnanolone are considered marke... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does bair hugger forced-air warming maintain normothermia more effectively than thermo-lite insulation? | [
"To compare the ability of forced-air warming and reflective insulation to maintain intraoperative normothermia. Prospective, randomized clinical trial. Operating rooms of a general hospital. 20 ASA physical status I and II patients undergoing elective total hip arthroplasty. Patients were randomly assigned to be w... | [
"Thermal management of the very low-birthweight (VLBW) infant is a cornerstone of neonatology because thermal stress is an important determinant of survival. This prospective study was designed to determine the effects of polyethylene occlusive skin wrapping on heat loss in VLBW infants admitted to the neonatal int... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is platelet-induced vascular smooth muscle cell proliferation modulated by the growth amplification factors serotonin and adenosine diphosphate? | [
"Platelet-mediated mechanisms have been implicated in intimal lesion formation following vascular injury. Although the participation of peptide growth factors has been suspected in this process, little has been known about the possible mitogenic role of other platelet factors that are released at sites of vascular ... | [
"Adenosine plays an important role in the pathogenesis of homocysteine-associated vascular complications. This study examined the effects of dipyridamole, an inhibitor for nucleoside transport, on impaired angiogenic processes caused by homocysteine and adenosine in human cardiovascular endothelial cell line (EAhy9... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does allelic variation in the D4 dopamine receptor ( DRD4 ) gene predict response to clozapine? | [
"To test the hypothesis that interindividual differences in response to clozapine therapy might be attributable to the D4 dopamine receptor (DRD4) alleles they carry. Different alleles of the D4 dopamine receptor, coded by the DRD4 gene, differ in the affinity with which they bind the atypical antipsychotic drug cl... | [
"To test the hypothesis that the interaction between the brain-derived neurotrophic factor (BDNF) and dopamine receptor D(2) (DRD2)/ANKK1 gene contributes to individual differences in alexithymia. The personality construct of alexithymia refers to difficulties in emotional self-regulation and contributes as a risk ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do prolyl hydroxylase inhibitor and lysyl hydroxylase inhibitor inhibit spreading of corneal epithelium? | [
"The spreading of epithelium is critical in the healing of corneal wounds. Such epithelial spreading requires the continuous production of protein and glycoprotein. To determine whether collagen production is required for the spreading of corneal epithelium, we studied the effects of inhibitors for collagen product... | [
"To characterize the molecular changes that occur in normal fibroblasts, adhesion fibroblasts, and mesothelial cells as a result of exposure to modified hyaluronic acid and carboxymethylcellulose (Seprafilm). University research laboratory. Human mesothelial and fibroblast cell culture. Multiplex reverse transcript... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is the hepatocellular uptake of free fatty acids selectively preserved during starvation? | [
"The liver loses protein during fasting. This study sought to determine if hepatic protein loss during fasting selectively preserves functions important to survival such as uptake of fatty acids, which are major energy substrates in that condition. Initial [3H]oleate uptake and efflux rates in hepatocytes from star... | [
"It has been proposed that muscle insulin resistance in type 2 diabetes is due to a selective decrease in the components of the mitochondrial electron transport chain and results from accumulation of toxic products of incomplete fat oxidation. The purpose of the present study was to test this hypothesis. Rats were ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does prostaglandin E2 enhance gastric defense mechanisms against acid injury in uremic rats? | [
"Uremia increases gastric mucosal H+ permeability and acid back-diffusion-related injury in rats. The aim of this study was to examine the effect of the synthetic gastroprotective compound 16,16-dimethyl prostaglandin E2 (16,16-dm PGE2) on the gastric barrier to acid injury in uremic rats. Chronic renal failure was... | [
"Gut ischemia/reperfusion (I/R) injury is a serious condition in intensive care patients. Activation of immune cells adjacent to the huge endothelial cell surface area of the intestinal microvasculature produces initially local and then systemic inflammatory responses. Stimulation of the vagus nerve can rapidly att... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does hyperglycemia induce abnormalities of gastric myoelectrical activity in patients with type I diabetes mellitus? | [
"Blood glucose concentration has been shown to be an important factor in gastric motility. However, the effect of hyperglycemia on gastric myoelectrical activity has not yet been studied in patients with diabetes. Surface electrogastrography was performed in eight patients with type I diabetes mellitus under normog... | [
"The results of the EUCLID trial (EURODIAB Controlled Trial of Lisinopril in Insulin-dependent Diabetes Mellitus) highlighted the importance of the renin-angiotensin system in the pathogenesis of diabetic retinopathy. Candesartan cilexetil (TCV-116), a potent angiotensin II (AII) receptor antagonist, has beneficial... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is biosynthesis of human colonic mucin : Muc2 the prominent secretory mucin? | [
"Human colonic epithelium produces large amounts of mucin. The aim of this study was to examine mucin biosynthesis in the human colon. Human colonic mucin was isolated using CsCl density gradients, and polyclonal antiserum was raised. Biosynthesis of colonic mucins was studied by labeling colonic explants with 35S-... | [
"The molecular cross-talk between commensal bacteria and the gut play an important role in the maintenance of the intestinal homeostasis and general health. Here, we studied the impact of a major Gram-positive anaerobic bacterium of the human gut microbiota, that is, Ruminococcus gnavus on the glycosylation pattern... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does effect of L-arginine on acetylcholine-induced endothelium-dependent vasodilation differ between the coronary and forearm vasculatures in humans? | [
"The goal of this study was to determine whether the effect of L-arginine on endothelium-dependent vasodilation evoked with acetylcholine differs between the coronary and forearm vasculatures in humans. Administration of L-arginine, a substrate in the production of endothelium-derived nitric oxide, may stimulate th... | [
"Pregnant women with diabetes mellitus have a higher incidence of adverse pregnancy outcomes. Vascular, and in particular, endothelial function may be significantly modified in diabetes resulting in impaired endothelium-dependent relaxation. This study aims to investigate endothelium-dependent relaxation in pregnan... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do methionine-enkephalin concentrations correlate with stage of disease but not pruritus in patients with primary biliary cirrhosis? | [
"Opiate antagonist agents ameliorate pruritus in some patients with cholestatic liver disease, suggesting that endogenous opioids may mediate pruritus in cholestasis. However, the endogenous opioids potentially responsible for pruritus remain unknown. Methionine-enkephalin is an endogenous opioid synthesized in num... | [
"The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only six published cases so far. Here we report two cases showing the clinical manifestations of both primary biliary cirrhosis and primary sclerosing cholangitis. In o... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does hypoglycemia increase muscle sympathetic nerve activity in IDDM and control subjects? | [
"The relationship between the increase in adrenomedullary catecholamine secretion and the sympathetic response to hypoglycemia is not well understood in humans. To explore this relationship more closely, we directly muscle sympathetic nerve activity (MSNA) in control subjects and in insulin-dependent diabetes melli... | [
"Diabetes is reported to accelerate sarcopenia (age-related loss of muscle mass and function). We aimed to assess muscle mass and strength in elderly diabetics, elderly non-diabetics, younger diabetics and healthy subjects, and to define correlates of muscle mass and strength in these subjects. Sixteen elderly diab... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does chicken and fish diet reduce glomerular hyperfiltration in IDDM patients? | [
"To compare the effect of a normal protein diet (test diet) in which chicken and fish were substituted for red meat with a low-protein diet (LPD) on glomerular filtration rate (GFR) in normoalbuminuric insulin-dependent-diabetes mellitus (IDDM) patients. A crossover randomized clinical trial was performed in 15 nor... | [
"Development of diabetes causes early functional (endothelial dysfunction) and morphological abnormalities in the kidney. If left untreated, these will ultimately progress to renal failure. Apart from strategies aimed at maintaining very tight glycemic control, attention has turned to the development of adjuvant th... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does accuracy and influence of ascorbic acid on glucose-test with urine dip stick in prenatal care? | [
"In Germany, urine analysis with dip sticks are used for screening of gestational diabetes. Our goal was to find the cut-off levels of glucose dip sticks and evaluate the influence of ascorbic acid on the result. We took urine samples of 152 pregnant patients between 01/2004 and 10/2004. The glucose content of the ... | [
"To observe pharmacological difference between ultra-fine particles of six ingredient Rehmannia pill and traditional six ingredient Rehmannia pill. Pharmacokinetic index was measured by death rate, and pharmacology actions were compared by anti-fatigue, hypoglycemic, clearance rate of charcoal particle, hypoxia res... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are iL-10 promoter and IL4-Ralpha gene SNPs associated with immediate beta-lactam allergy in atopic women? | [
"Allergic reactions to beta-lactam antibiotics represent the most frequent cause of immunological drug reactions. This study evaluates the involvement of genetic susceptibility factors in patients with immediate allergic reactions to beta-lactams. We examined 15 single nucleotide polymorphisms (SNP) of genes coding... | [
"Steroid-sensitive nephrotic syndrome (NS) of childhood is the most common glomerular disease in children. The type and duration of response to corticosteroid therapy are used for clinical classification, and especially patients with steroid dependence often have a complicated course, requiring intensified immunosu... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is cellular immune reaction in the pancreas induced by constitutively active IkappaB kinase-2? | [
"Activation of the nuclear factor kappaB (NF-kappaB) system is a major event in acute and chronic inflammatory processes. NF-kappaB cascades are comprised of IkappaB kinases, IkappaBs and NF-kappaB dimers. Little is known of the individual roles of these proteins in organ specific inflammation. The aim of the prese... | [
"Inflammatory reaction and intimal proliferation of smooth muscle cells are characteristics of vascular stenotic lesions. Nuclear factor kappaB (NF-kappaB) is involved in regulation of inflammation and cell survival in a variety of cell types. We tested a hypothesis that selective inhibition of NF-kappaB by express... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does seroprevalence and correlate of herpes simplex virus type-2 infection in a general gynecology clinic? | [
"Up to two-thirds of individuals acquire herpes asymptomatically and most infected persons shed the virus during latency periods. Genital infection is frequently associated with the presence of other sexually transmitted diseases. The objective of this paper was to assess the seroprevalence of HSV-2 in a low risk p... | [
"Previous studies have suggested an association of viral hepatitis with alcoholism, although the role of confounding risk factors (e.g. i.v. drug use) has not been adequately excluded. We therefore compared the seroprevalences of hepatitis B and C in alcoholic patients to that of a nonalcoholic control group. Hepat... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do antagonist peptides of human interferon-alpha2b isolated from phage display library inhibit interferon induced antiviral activity? | [
"To screen human interferon (IFN)-alpha2b antagonist peptides from a phage displayed heptapeptide library. WISH cells and polyclonal anti-IFN-alpha2b antibodies were used to select IFN receptor-binding peptides from a phage displayed heptapeptide library. The specific binding of phage clones was examined by phage E... | [
"Microbe-induced over-activation of cytokines, especially tumour necrosis factor (TNF)-α, is key to the pathogenesis of hantavirus infection leading to severe inflammation with high mortality rate. Although ribavirin showed promise in inhibiting viral replication in vitro, its clinical efficacy remains controversia... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is weekly docetaxel and capecitabine effective in the treatment of advanced gastric cancer : a phase II study? | [
"Capecitabine and docetaxel have demonstrated preclinical antitumor synergy and activity in advanced gastric cancer. We assessed the clinical activity and the toxicity of weekly docetaxel in combination with capecitabine in untreated patients with advanced gastric cancer. A total of 38 patients were treated with do... | [
"This article reviews the recent seminal studies in esophagogastric cancer. Regular low aspirin use may reduce the risk of esophagogastric cancer. Laparoscopic resection of locally advanced gastric cancer appears equivalent to open resection. There is no survival benefit for the addition of postoperative radiation ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is pleural fluid/serum immunoglobulin ratio a diagnostic marker for congenital chylothorax in utero? | [
"To distinguish congenital chylothorax from other causes of hydrothorax in utero. Serum and pleural fluid samples from 8 fetuses with congenital chylothorax and 5 control fetuses with other causes of hydrothorax were tested for total protein, albumin, IgG, IgA, and IgM. Fetuses with congenital chylothorax had highe... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is ethnic distribution of estrogen receptor-alpha polymorphism associated with a higher prevalence of uterine leiomyomas in black Americans? | [
"To investigate whether polymorphisms in the estrogen receptor alpha (ERalpha) gene are associated with an increased risk of uterine leiomyomas (ULMs). Genomic DNA was isolated from normal myometrium samples collected at the time of the hysterectomy. Volunteers in an academic research environment. One hundred ninet... | [
"Selenium has been shown to inhibit cancer development and growth through the mediation of selenium-binding proteins. Decreased expression of selenium-binding protein 1 has been reported in cancers of the prostate, stomach, colon, and lungs. No information, however, is available concerning the roles of selenium-bin... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is the positive effect of dietary vitamin D intake on bone mineral density in men modulated by the polyadenosine repeat polymorphism of the vitamin D receptor? | [
"Few studies have considered the dietary influence of vitamin D intake on bone mineral density (BMD). Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD. We therefore conducte... | [
"Although bone loss and osteoporosis are well-known long-term sequelae of inflammatory bowel disease (IBD), the risk factors for increased bone loss have not been identified. Balances of pro- and anti-inflammatory cytokines influence mechanisms of both chronic inflammation and bone resorption. The aim of this study... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does a powerful method for detecting differentially expressed genes from GeneChip arrays that require replicates? | [
"Studies of differential expression that use Affymetrix GeneChip arrays are often carried out with a limited number of replicates. Reasons for this include financial considerations and limits on the available amount of RNA for sample preparation. In addition, failed hybridizations are not uncommon leading to a furt... | [
"Affymetrix microarray technology allows one to investigate expression of thousands of genes simultaneously upon a variety of conditions. In a popular U133A microarray platform, the expression of 37% of genes is measured by more than one probeset. The discordant expression observed for two different probesets that ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does osteoporosis increase the severity of cartilage damage in an experimental model of osteoarthritis in rabbits? | [
"To evaluate the effect of osteoporosis (OP) in cartilage damage developed in an experimental model of osteoarthritis (OA) in mature female rabbits in order to investigate the relationship between OP and OA. OA was experimentally induced by anterior cruciate section and partial medial meniscectomy in the left knee ... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does emotionally expressive coping reduce pregnancy rates in patients undergoing in vitro fertilization? | [
"To examine the effects of coping and of infertility-specific and nonspecific stress on pregnancy outcomes after IVF treatment. Cross-sectional design controlling for potential confounding variables. Psychosocial measures were assessed on the day of embryo transfer. Fertility clinic in Greece. Three hundred forty-t... | [
"Is there a difference in fertility between heterosexual women and lesbians undergoing sperm donation?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does increase in incidence of hyperthyroidism predominantly occur in young people after iodine fortification of salt in Denmark? | [
"To prevent goiter and nodular hyperthyroidism, iodine fortification (IF) of salt was introduced in Denmark in 1998. We prospectively registered all new cases of overt hyperthyroidism in two areas of Denmark before and for the first 6 yr after iodine fortification. We used a computer-based register of all new cases... | [
"Belgium used to be affected by mild iodine deficiency. Improvement in iodine nutrition has been recently documented in schoolchildren in Belgium in spite of the absence of any systematic programme of iodine supplementation. The question arises as to whether this 'silent iodine prophylaxis' affected also the neonat... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is the canine copper toxicosis gene MURR1 implicated in the pathogenesis of Wilson disease? | [
"It has recently been demonstrated that the Wilson disease (WD) protein directly interacts with the human homolog of the MURR1 protein in vitro and in vivo, and that this interaction is specific for the copper transporter. The aim of the present study was to clarify the role of MURR1 in the pathogenesis of WD as we... | [
"Glaucoma in humans is a second leading cause of irreversible vision loss in the world and can affect all age groups as well as all populations. The precise mechanism of retinal ganglion cell (RGC) death and progressive degeneration of optic nerve in glaucoma is not understood. It has been suggested that apoptosis ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are bone marrow endothelial progenitors defective in systemic sclerosis? | [
"Vascular abnormalities represent the main component of the pathobiology of systemic sclerosis (SSc), progressing from structural derangements of the microcirculation with abortive neoangiogenesis to final vessel loss. Since circulating endothelial progenitor cells (EPCs) are important in the vascular repair proces... | [
"Are levels of circulating angiogenic cells (CACs) affected by the presence of endometriosis?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does trendelenburg positioning prevent a decrease in cardiac output after induction of anaesthesia with propofol in children? | [
"Induction of anaesthesia may cause decreased cardiac output and blood pressure. Head-down tilt is often the first clinical step to treat hypotension. The objective of this randomized single centre study was to determine, with the use of impedance cardiography (ICG), whether Trendelenburg positioning modifies the h... | [
"Hip fracture is common in the geriatric population. Patients in this group are often at high risk for perioperative complications from concurrent diseases. Conventional spinal anesthesia can be associated with hypotension but has a better postoperative outcome compared to general anesthesia. We judged that a reduc... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does interleukin-5 influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo? | [
"Interleukin-5 (IL-5) promotes signal transduction and expansion of eosinophil colonies in bone marrow via interactions with its heterodimeric receptor (IL-5R). Two variants encoding soluble forms of the alpha subunit (sIL-5R alpha) have been described, although the signals promoting and/or limiting differential tr... | [
"The basic pathological features of bronchial asthma can be explained on the basis of chronic airway inflammation, involving inflammatory cells such as T cells (particularly type 2 helper T, Th2, cells) and mast cells, and airway remodeling. Many aspects of airway remodeling remain unclear at the molecular level. R... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is oral peppermint oil a useful antispasmodic for double-contrast barium meal examination? | [
"Intraluminally administered peppermint oil (PO) is reportedly a safe and useful antispasmodic for gastroscopy, colonoscopy and double-contrast barium enema. The aim of this study was to examine the efficacy of oral PO for double-contrast barium meal examination (DCBM) without other antispasmodics. Two hundred and ... | [
"Bladder spasms are a common cause of pain after surgical procedures that call for postoperative catheter drainage. Several therapeutic methods have been used to lessen these spasms but none have received widespread success. Twenty-six children were included in a prospective randomized trial to evaluate the safety ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is subcarinal node the significant node that affects survival in resected small cell lung cancer? | [
"Our aim was to clarify the significance of surgery and the prognostic factors in patients with small cell lung cancer (SCLC). A retrospective review of 50 patients with limited SCLC who underwent a pulmonary resection and mediastinal nodal dissection during the 10-year period from 1988 to 1997 was undertaken. The ... | [
"One of the sites most frequently invaded by gastric cancer is the mesocolon; however, the UICC does not mention this anatomical site as an adjacent structure involved in gastric cancer. The purpose of this study was to characterize and classify mesocolon invasion from gastric cancer. We examined 806 patients who u... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does a single nucleotide polymorphism in the CCL1 gene predict acute exacerbations in chronic obstructive pulmonary disease? | [
"Acute exacerbations (AEs) in chronic obstructive pulmonary disease (COPD) are a major cause of morbidity and mortality in COPD. The marked heterogeneity in the host defense mechanisms may be attributed to single nucleotide polymorphisms (SNPs) in the inflammatory chemokines that show enhanced expression in the air... | [
"In this study we set out to investigate the clinically observed relationship between chronic obstructive pulmonary disease (COPD) and aortic aneurysms. We tested the hypothesis that an inherited deficiency of connective tissue might play a role in the combined development of pulmonary emphysema and vascular diseas... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does a systematic review of diagnostic utility of selective nerve root block? | [
"Transforaminal epidural injections, or selective nerve root blocks, are used for a myriad of different spinal disorders. A clear consensus on the use of selective nerve root injections as a diagnostic tool does not currently exist. Additionally, the effectiveness of this procedure as a diagnostic tool is not clear... | [
"Diagnostic value of available tumor markers, such as cancer antigen CA 15-3 and carcinoembryonic antigen (CEA) in breast cancer is limited. There is an ongoing search for additional, potentially better diagnostic blood markers with improved clinical utility. The aim of this study is to evaluate performance of the ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does fluvastatin prevent oxidized low-density lipoprotein-induced injury of renal tubular epithelial cells by inhibiting the phosphatidylinositol 3-kinase/Akt-signaling pathway? | [
"Lipid abnormalities may play a role in the progression of nephrosis. Recent studies have demonstrated that oxidized low-density lipoprotein (oxLDL) appears to be a detrimental factor for the glomerular mesangium and podocytes. The aim of the present study is to identify the potential effects of oxLDL on tubular ep... | [
"Kakkalide is the predominant isoflavone derived from the flowers of Pueraria lobata (Willd.) Ohwi. The aim of the present study was to investigate the effects of kakkalide on insulin resistance in the endothelium. Human umbilical vein endothelial cells (HUVEC) were stimulated with 100 μmol/L palmitate (PA) for 30 ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does preproghrelin Leu72Met variant contribute to overweight in middle-aged men of a Japanese large cohort? | [
"To investigate whether Leu72Met polymorphism of the preproghrelin gene is associated with overweight/obesity in middle-aged and older Japanese. Cross-sectional analysis. A total of 2238 community-dwelling middle-aged and older Japanese people (age: 40-79 years) who participated in the first wave of examinations in... | [
"What are the relationships between telomere lengths in leukocytes and sperm, sperm count and parents' age at conception in a group of apparently healthy subjects of the same age?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins? | [
"Iron-binding proteins H-ferritin (HF) and lactoferrin (LF), as well as chemokines, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma suppress hematopoietic progenitor cell (HPC) proliferation. Major histocompatibility complex (MHC) class II antigens have been associated with suppressive effects of HF a... | [
"Activation of innate pattern-recognition receptors promotes CD4+ T-cell-mediated autoimmune myocarditis and subsequent inflammatory cardiomyopathy. Mechanisms that counterregulate exaggerated heart-specific autoimmunity are poorly understood. Experimental autoimmune myocarditis was induced in BALB/c mice by immuni... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does the CXCR4 antagonist AMD3100 release a subset of G-CSF-primed peripheral blood progenitor cells with specific gene expression characteristics? | [
"AMD3100 is a new CXCR4 antagonist that induces a rapid release of hematopoietic progenitors from the bone marrow to the peripheral blood. We conducted a clinical study where patients with multiple myeloma and non-Hodgkin's lymphoma were treated with AMD3100 (A) to increase the number of peripheral blood progenitor... | [
"Tissue inhibitor of metalloproteinases-3 (TIMP-3) inhibits matrix metalloproteinases and membrane-bound sheddases. TIMP-3 is associated with the extracellular matrix and is expressed in highly remodeling tissues. TIMP-3 function in the hematopoietic system is unknown. We now report that TIMP-3 is highly expressed ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does inhibition of mTOR reduce chronic pressure-overload cardiac hypertrophy and fibrosis? | [
"Inhibition of established left ventricular hypertrophy (LVH) and fibrosis may bring clinical benefits by reducing cardiac morbidity and mortality. The mammalian target of rapamycin, mTOR, is known to play a critical role in determining cell and organ size. We investigated whether mTOR inhibition can inhibit the ch... | [
"Diabetes increases the risk for fatal myocardial infarction and development of heart failure. Levosimendan, an inodilator acting both via calcium sensitization and opening of ATP-dependent potassium channels, is used intravenously for acute decompensated heart failure. The long-term effects of oral levosimendan on... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is duplex ultrasound scanning reliable in the detection of endoleak following endovascular aneurysm repair? | [
"To investigate the value of duplex ultrasound scanning (DUSS) in the routine follow up of patients following EVAR. Imaging was reviewed for 310 consecutive patients undergoing EVAR at a single centre. Concurrent ultrasound and CT scans were defined as having occurred within 6 months of each other. There were 244 p... | [
"Statins are an essential component of the therapeutic approach of patients with atherosclerotic disease. Statin use is also associated with improved peri-operative and long-term outcomes in these patients. We aimed to define the role of statin treatment in patients undergoing percutaneous revascularization procedu... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is adiponectin an independent predictor of all-cause mortality , cardiac mortality , and myocardial infarction in patients presenting with chest pain? | [
"To determine the prognostic value of baseline plasma adiponectin levels in patients with known or suspected coronary artery disease referred for coronary angiography. Adiponectin was measured in 325 male patients with stable angina, troponin-negative unstable angina, and non-ST-segment elevation myocardial infarct... | [
"The purpose of this study was to examine the impact of sulfonylurea drug use on outcome in diabetic patients undergoing direct coronary angioplasty for acute myocardial infarction. Sulfonylurea drugs impair ischemic preconditioning. Whether sulfonylurea drugs affect outcome adversely in diabetic patients undergoin... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are treatments with losartan or enalapril equally sensitive to deterioration in renal function from cyclooxygenase inhibition? | [
"The beneficial effects of angiotensin converting enzyme (ACE)-inhibitors are in part mediated through the inhibition of the degradation of the vasodilator bradykinin. The bradykinin effect is counteracted by cyclooxygenase-inhibitors. Angiotensin receptor blockers (ARBs) do not affect bradykinin. To test the hypot... | [
"Development of diabetes causes early functional (endothelial dysfunction) and morphological abnormalities in the kidney. If left untreated, these will ultimately progress to renal failure. Apart from strategies aimed at maintaining very tight glycemic control, attention has turned to the development of adjuvant th... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is factor V Leiden commonly associated with idiopathic portal vein thrombosis in southern India? | [
"Factor V Leiden has been reported in 2%-30% of patients with portal vein thrombosis. This wide variation makes it difficult to assess the importance of factor V Leiden as a predisposing factor. Factor V Leiden was determined by restriction fragment length polymorphism in 112 patients with portal vein thrombosis, 1... | [
"Do platelets play any role in the development of endometriosis?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does lens-specific expression of TGF-beta induce anterior subcapsular cataract formation in the absence of Smad3? | [
"Smad3, a mediator of TGF-beta signaling has been shown to be involved in the epithelial-to-mesenchymal transformation (EMT) of lens epithelial cells in a lens injury model. In this study, the role of Smad3 in anterior subcapsular cataract (ASC) formation was investigated in a transgenic TGF-beta/Smad3 knockout mou... | [
"Brahma-related gene 1 (Brg1, also known as Smarca4 and Snf2β) encodes an adenosine-5'-triphosphate (ATP)-dependent catalytical subunit of the (switch/sucrose nonfermentable) (SWI/SNF) chromatin remodeling complexes. SWI/SNF complexes are recruited to chromatin through multiple mechanisms, including specific DNA-bi... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are racial differences seen in blood pressure response to fosinopril in hypertensive children? | [
"Few antihypertensive therapies have been systematically studied in children and dosages for many agents are either extrapolated from adult studies or obtained from small homogenous pediatric populations. It is well established that adult patients of different races show disparate response to angiotensin-converting... | [
"Controversies surrounding the physiological effects of hormone replacement therapy (HRT) currently lie at the forefront of medicine. Important interindividual factors that affect blood pressure, such as smoking, body mass and sodium intake, may account for the conflicting findings seen in studies examining the eff... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is low voltage on the electrocardiogram a marker of disease severity and a risk factor for adverse outcomes in patients with heart failure due to systolic dysfunction? | [
"The prognostic implications of low QRS voltage on the electrocardiogram (ECG) in heart failure (HF) are not well characterized. We manually measured and summed the QRS voltage in all 12 leads of the ECG (sumQRS) in two cohorts: (1) 415 patients with a low left ventricular ejection fraction followed up in a HF clin... | [
"It is unclear whether diabetes mellitus (DM) is an adverse prognostic factor in chronic heart failure (CHF) of ischaemic and non-ischaemic aetiology managed with contemporary evidence-based care. In total, 1091 outpatients with CHF with reduced ejection fraction were prospectively observed for a mean of 960 days. ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does ginsenoside Rg1 inhibit proliferation of vascular smooth muscle cells stimulated by tumor necrosis factor-alpha? | [
"To investigate the proliferation of vascular smooth muscle cells (VSMC) affected by ginsenoside Rg1 and further explore the molecular mechanism of ginsenoside Rg1 using proteomics. The proliferation of VSMC was measured by MTS assay kit and flow cytometry. Proteomic alterations were analyzed using two-dimensional ... | [
"High invasiveness of glioma cells is one of the reasons that patients with malignant glioma have a poor prognosis. Resveratrol, a plant compound abundant in the peel of grapes, has been suggested as a potential cancer chemopreventive agent. Therefore, we investigated the effect of resveratrol on glioma cell invasi... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does prolonged ovalbumin exposure attenuate airway hyperresponsiveness and T cell function in mice? | [
"Continuous exposure of sensitized mice to an innocuous antigen, such as OVA, does not lead to chronic airway eosinophilia, but induces antigen unresponsiveness and resolution of the inflammatory response. In this study we explored mechanisms underlying attenuation of the airway inflammatory response, assessed whet... | [
"Epidemiologic and clinical observations identify obesity as an important risk factor for asthma exacerbation, but the underlying mechanisms remain poorly understood. Type 2 innate lymphoid cells (ILC2s) and type 3 innate lymphoid cells (ILC3s) have been implicated, respectively, in asthma and adipose tissue homeos... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does sensitivity and specificity of des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinomas vary according to tumor size? | [
"Serum levels of des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) are known to be useful tumor markers for the diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to examine the diagnostic efficacy of DCP and AFP in differentiating HCC from chronic liver diseases. We examined 1,377... | [
"Altered CA19-9 levels are commonly found in patients with liver cirrhosis though a clear explanation for this finding has not yet been given. The aim of this study was to investigate whether CA19-9 levels might be related to alterations in biochemical parameters and/or to functional impairment in cirrhotic patient... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does nonlinear association of higher-level functional capacity with the incidence of fall in Japan? | [
"To examine the nonlinear association of higher-level functional capacity with the incidence of falls. We analyzed the cross-sectional data of Minamifurano-town Aging Study. Seven hundred forty-three noninstitutionalized older persons aged 65 yrs or older were mailed a self-administered questionnaire in June 2002 i... | [
"To describe a broad range of physical disability by examining the association between a four-level measure of disability, based on self-report of difficulty in performing functional activities, and previously identified risk factors for disability. Cross-sectional. Community-based. A total of 2373 noninstitutional... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is the number of Baby Friendly hospital practices experienced by mothers positively associated with breastfeeding : a questionnaire survey? | [
"The objective of this study was to examine the association between number of Baby Friendly hospital practices (based on World Health Organization/United Nations Children's Fund Ten Steps to successful breastfeeding) experienced by mothers and breastfeeding initiation during hospital stay, breastfeeding at 1 month ... | [
"To identify and evaluate which psychosocial criteria are associated with preterm birth in a midwifery model of risk in pregnancy. A quantitative study with a prospective correlational research design. Women attending three prenatal clinics in East Tennessee. 120 pregnant women between 16 and 28 weeks gestation. Th... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is metabolic inflexibility in substrate use present in African-American but not Caucasian healthy , premenopausal , nondiabetic women? | [
"There is an increased prevalence of obesity and insulin resistance in African-American compared with Caucasian females. Metabolic inflexibility (MI) is the inability to switch the use of lipids and carbohydrates in the peripheral tissue (i.e. muscle) based upon substrate availability. We examined whether MI exists... | [
"What is the effect of glucose ingestion on leukocytic reactive oxygen species (ROS) generation in normal-weight women with polycystic ovary syndrome (PCOS) with and without excess abdominal adiposity (AA)?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is clusterin essential for androgen-regulated involution and regeneration of the normal mouse prostate? | [
"Inhibition of clusterin expression has been shown to enhance the sensitivity of prostate cancer cells to chemo and hormone therapy. Clusterin antisense oligonucleotides (ASOs) are currently in phase II human clinical trials for treatment of hormone refractory prostate cancer. However, the role of clusterin in andr... | [
"Does intrauterine biosynthesis of estrogen play an important role in early pregnancy by altering the function of uterine natural killer (uNK) cells?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is dysregulation of muscle fatty acid metabolism in type 2 diabetes independent of malonyl-CoA? | [
"An elevated lipid content within skeletal muscle cells is associated with the development of insulin resistance and type 2 diabetes mellitus. We hypothesised that in subjects with type 2 diabetes muscle malonyl-CoA (an inhibitor of fatty acid oxidation) would be elevated at baseline in comparison with control subj... | [
"Complex changes in gene expression are associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD) promoted by feeding a high-fat diet (HFD). We used functional genomic technologies to document molecular mechanisms associated with diet-induced NAFLD. Male 129S6 mice were fed a diet containing ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does metformin influence cardiomyocyte cell death by pathways that are dependent and independent of caspase-3? | [
"Metformin has been shown to increase fatty acid oxidation, an effect mediated by AMP activated protein kinase (AMPK). We hypothesised that metformin could prevent both caspase-3 activation and apoptosis when induced by palmitic acid. Cardiomyocytes were incubated with 1 mmol/l palmitic acid, in the absence or pres... | [
"Growth Arrest Specific gene product 6 (gas6) is a gamma-carboxylated protein that protects endothelial cells against apoptosis. Gas6 has previously been shown to induce phospatidyl-3-inositol-kinase (PI3K)/Akt signaling. Other studies have demonstrated a link between PI3K/Akt signaling and forkhead transcription f... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is proximal loop jejunostomy a useful adjunct in the management of multiple intestinal suture lines in the septic abdomen? | [
"Bowel repair in the septic abdomen can be problematic. This study investigated the use of a proximal loop jejunostomy to protect injured or fistulated bowel that had been returned to the abdomen after repair and/or anastomosis. Ten patients who underwent laparotomy for intra-abdominal sepsis and/or fistulation, fo... | [
"With new advances in diagnostic and therapeutic tools, the early management of adhesive bowel obstruction has become feasible. In a retrospective study, 20 children with adhesive bowel obstruction were investigated to assess the possible advantages of the laparoscopic approach. Laparoscopy was performed in nine ch... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does [ Phenol butyrate inhibit cell cycle of leukemia cell lines through up-regulation of p21WAF1/CIP1 gene ]? | [
"To elucidate effects of histone deacetylase inhibitors on cell cycle of leukemia cell lines and investigate its molecular mechanisms. Kasumi-1, U937 and NB4 cell lines were exposed to a histone deacetylase inhibitor, phenyl butyrate (PB), for 24, 48 and 72 hrs. Cells were harvested for cell cycle analysis by flow ... | [
"To investigate the effects of medroxyprogesterone acetate on colon cancer cells in vitro. HT29 and HCT116 human colon cancer cell lines were used in this study. Cell growth and WST-1 assays were performed to investigate the antiproliferative effect of medroxyprogesterone acetate. Cell cycle analysis was performed ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is tRPC3 involved in flow- and bradykinin-induced vasodilation in rat small mesenteric arteries? | [
"To test the possible involvement of TRPC3 in agonist-induced relaxation and flow-induced vasodilation in rat small mesenteric arteries. Male Sprague-Dawley rats were used in the present study. After 72 h-treatment of antisense oligo via tail vein injection, isometric tension and isobaric diameter measurement were ... | [
"Exercise training enhances vasodilatation to vascular endothelial growth factor (VEGF(165)) in collateral-dependent coronary arterioles. Interaction of VEGF receptor 2 (VEGFR-2) and the non-tyrosine-kinase receptor, neuropilin-1 has been reported to potentiate VEGF(165)-mediated signaling. In the current study, we... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does addition of tanshinone IIA to UW solution decrease skeletal muscle ischemia-reperfusion injury? | [
"To investigate whether tanshinone IIA could improve the effect of UW solution for skeletal muscle preservation and to determine the dose range of tanshinone IIA providing optimal protection during ischemia and reperfusion. Ischemic rat limbs were perfused with UW solution or UW plus tanshinone IIA (UW+T, 0.05, 0.1... | [
"Excessive oxidative stress is a main cause of lung ischemia-reperfusion injury, which often results in respiratory insufficiency after open-heart surgery for a cardiopulmonary bypass. Previous studies demonstrate that the activation of aldehyde dehydrogenase-2 could significantly reduce the oxidative stress mediat... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does dexamethasone protect against Cisplatin-induced activation of the mitochondrial apoptotic pathway in human osteosarcoma cells? | [
"Dexamethasone (Dx) is often used to alleviate the acute emetic toxicity associated with high dose cisplatin (cDDP) in osteosarcoma patients. However, in other tumour cell types, Dx has been reported to induce partial resistance to anticancer drugs. We examined the effect of Dx on cDDP-induced apoptosis in the HOS ... | [
"Does halofuginone (HF) inhibit the growth of human uterine leiomyoma cells in a mouse xenograft model?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is the scalp an advantageous donor site for thin-skin grafts : a report on 945 harvested samples? | [
"Thin-skin grafts taken from the thigh or buttock take a long time to heal and leave permanent scars. The authors conducted a retrospective study based on their experience with 945 thin-skin grafts (0.2 mm) taken from the scalps of 757 adult patients between January of 1999 and December of 2003. Of the 757 patients... | [
"Severe neck contracture is a problem that must be resolved by priority. We consider the best contracture treatment to be the full-thickness skin graft. However, clinicians often encounter patients, especially extensive burn patients, who have insufficient donor sites for the full-thickness skin graft. We treated e... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does dementia severity of the care receiver predict procoagulant response in Alzheimer caregivers? | [
"The procoagulant factor D-dimer has been shown to be associated with thrombus formation and degradation as seen with conditions such as myocardial infarction and unstable angina. Research has demonstrated that spousal dementia caregivers have elevated levels of D-dimer relative to their non-caregiving peers. The o... | [
"(1) To assess the prevalence of depressive disorders in a sample of diabetic patients with their first superficial diabetic foot ulcer. (2) To evaluate the association between illness invalidation from spouse, family, and depressive disorders in those patients. Depressive disorders and severity were diagnosed by t... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does novel HSF4 mutation cause congenital total white cataract in a Chinese family? | [
"To identify the disease-causing gene (mutation) in a Chinese family affected with autosomal dominant congenital total white cataract. Observational case series. Genotyping and linkage analyses were used to identify the linkage of the disease-causing gene in the Chinese family to the HSF4 gene encoding a member of ... | [
"PLA2G6 mutations are known to be responsible for infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation (NBIA). In addition, novel mutations in PLA2G6 have recently been associated with dystonia-parkinsonism in two unrelated consanguineous families. Direct sequencing analysis of ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does melanin differentially protect from the initiation and progression of threshold UV-induced erythema depending on UV waveband? | [
"This study aimed to determine the relationship between various measures of constitutive skin pigmentation and erythema caused by solar-simulated UV (ssUV), 290 and 310 nm UV. Skin pigmentation was assessed clinically by skin typing as well as objectively by measurement of the melanin index (MI) by reflectance spec... | [
"N-palmitoylethanolamine (PEA) and organic osmolytes are endogenous components of the human epidermis and are generated from phospholipids in the stratum granulosum. PEA has been shown to exert potent antioxidant and anti-inflammatory activities. The endogenous organic osmolytes such as betaine and sarcosine contro... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does magnetic resonance quantitative myocardial perfusion reserve demonstrate improved myocardial blood flow after angiogenic implant therapy? | [
"The purpose of this study is to follow myocardial angiogenesis temporally using quantitative magnetic resonance first pass perfusion imaging and compare this with the \"gold standard\" of radioactive microspheres in a random subset of animals. Ameriod constrictors were placed around the left circumflex in 15 pigs ... | [
"Renovascular hypertension (RVHT) increases cardiovascular morbidity and mortality. Renal revascularization with percutaneous transluminal renal angioplasty and stenting (PTRS) may reverse RVHT but may not fully regress cardiac remodeling and damage, possibly due to persistent myocardial insults. Bendavia is a mito... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
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