pmcid string | abstract string | text string | metadata dict |
|---|---|---|---|
PMC176546 | The origin of Borneo's elephants is controversial. Two competing hypotheses argue that they are either indigenous, tracing back to the Pleistocene, or were introduced, descending from elephants imported in the 16th–18th centuries. Taxonomically, they have either been classified as a unique subspecies or placed under th... | # Introduction
Elephants have a very limited distribution in Borneo, being restricted to approximately 5% of the island in the extreme northeast [FIG_REF]. There are no historical records of elephants outside of this range. Fossil evidence for the prehistoric presence of elephants on Borneo is limited to a single spec... | {
"pmid": "12929206",
"doi": "10.1371/journal.pbio.0000006",
"article_title": "DNA Analysis Indicates That Asian Elephants Are Native to Borneo and Are Therefore a High Priority for Conservation",
"journal_title": "PLoS Biology",
"epub": "2003-08-18 00:00:00",
"authors": [
"Prithiviraj Fernando",
"T... |
PMC193605 | The rapid increase in published genomic sequences for bacteria presents the first opportunity to reconstruct evolutionary events on the scale of entire genomes. However, extensive lateral gene transfer (LGT) may thwart this goal by preventing the establishment of organismal relationships based on individual gene phylog... | # Introduction
The availability of complete sequences of genomes for clusters of related organisms presents the first opportunity to reconstruct events of genomic evolution. By comparing related genomes and inferring ancestral ones, we can identify events, such as specific chromosomal rearrangements, gene acquisitions... | {
"pmid": "12975657",
"doi": "10.1371/journal.pbio.0000019",
"article_title": "From Gene Trees to Organismal Phylogeny in Prokaryotes:The Case of the γ-Proteobacteria",
"journal_title": "PLoS Biology",
"epub": "2003-09-15 00:00:00",
"authors": [
"Emmanuelle Lerat",
"Vincent Daubin",
"Nancy A Mor... |
PMC212319 | # Background
Phospholipase D (PLD) is involved in many signaling pathways. In most systems, the activity of PLD is primarily regulated by the members of the ADP-Ribosylation Factor (ARF) family of GTPases, but the mechanism of activation of PLD and ARF by extracellular signals has not been fully established. Here we t... | # Background
Small GTPases of the ADP-ribosylation factor (ARF) family play a major role in membrane trafficking in eukaryotic cells [CIT_REF]. ARF activation is facilitated by specific guanine nucleotide exchange factors (ARF-GEFs). Several ARF-GEFs have been identified, varying in size, structure and subcellular dis... | {
"pmid": "12969509",
"doi": "10.1186/1471-2121-4-13",
"article_title": "The Guanine Nucleotide Exchange Factor ARNO mediates the activation of ARF and phospholipase D by insulin",
"journal_title": "BMC Cell Biology",
"epub": "2003-09-11 00:00:00",
"authors": [
"Hai-Sheng Li",
"Kuntala Shome",
"... |
PMC212692 | RNA-mediated interference (RNAi) is a method to inhibit gene function by introduction of double-stranded RNA (dsRNA). Recently, an RNAi library was constructed that consists of bacterial clones expressing dsRNA, corresponding to nearly 90% of the 19,427 predicted genes of C. elegans. Feeding of this RNAi library to the... | # Introduction
RNA interference (RNAi) is targeted gene silencing via double-stranded RNA (dsRNA); a gene is inactivated by specific breakdown of the mRNA [CIT_REF]. It is an ideal method for rapid identification of in vivo gene function. Initial studies on RNAi used microinjection to deliver dsRNA [CIT_REF], but it w... | {
"pmid": "14551910",
"doi": "10.1371/journal.pbio.0000012",
"article_title": "Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions",
"journal_title": "PLoS Biology",
"epub": "2003-10-13 00:00:00",
"authors": [
"Femke Simmer",
"Celine Moorman",
"Alexa... |
PMC212699 | Symbiotic relationships between bacteria and insect hosts are common. Although the bacterial endosymbionts have been subjected to intense investigation, little is known of the host cells in which they reside, the bacteriocytes. We have studied the development and evolution of aphid bacteriocytes, the host cells that co... | # Introduction
Endosymbiosis is common in insects, with more than 10% of insect species relying upon intracellular bacteria for their development and survival [CIT_REF]. Full genome sequencing of the endosymbiotic bacteria, Buchnera aphidicola, of several species of aphids has revealed extensive gene loss [CIT_REF], b... | {
"pmid": "14551917",
"doi": "10.1371/journal.pbio.0000021",
"article_title": "Developmental Origin and Evolution of Bacteriocytes in the Aphid– Buchnera Symbiosis",
"journal_title": "PLoS Biology",
"epub": "2003-10-13 00:00:00",
"authors": [
"Christian Braendle",
"Toru Miura",
"Ryan Bickel",
... |
PMC300881 | The JAMM (JAB1/MPN/Mov34 metalloenzyme) motif in Rpn11 and Csn5 underlies isopeptidase activities intrinsic to the proteasome and signalosome, respectively. We show here that the archaebacterial protein AfJAMM possesses the key features of a zinc metalloprotease, yet with a distinct fold. The histidine and aspartic aci... | # Introduction
Many cellular proteins are degraded by the proteasome after they become covalently modified with a multiubiquitin chain. The 26S proteasome is a massive protein composed of a 20S core and two 19S regulatory particles [CIT_REF]. The 20S core can be subdivided into a dimer of heptameric rings of β subunit... | {
"pmid": "14737182",
"doi": "10.1371/journal.pbio.0020002",
"article_title": "JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome",
"journal_title": "PLoS Biology",
"epub": "2003-11-24 00:00:00",
"authors": [
"Xavier I Ambroggio",
"Douglas C Rees",
"Raymond J Deshaies"
],... |
PMC300882 | Comparing genomic properties of different organisms is of fundamental importance in the study of biological and evolutionary principles. Although differences among organisms are often attributed to differential gene expression, genome-wide comparative analysis thus far has been based primarily on genomic sequence infor... | # Introduction
Microarray experiments are now being used to address a large diversity of biological issues. The large datasets obtained by pooling those experiments together contain a wealth of biological information beyond the insights gained by individual measurements. For example, it was demonstrated that diverse d... | {
"pmid": "14737187",
"doi": "10.1371/journal.pbio.0020009",
"article_title": "Similarities and Differences in Genome-Wide Expression Data of Six Organisms",
"journal_title": "PLoS Biology",
"epub": "2003-12-15 00:00:00",
"authors": [
"Sven Bergmann",
"Jan Ihmels",
"Naama Barkai"
],
"article... |
PMC300883 | "Spermatozoa are generated and mature within a germline syncytium. Differentiation of haploid syncyt(...TRUNCATED) | "# Introduction\n\nMost, if not all, cells have the potential to carry out the apoptotic cell death (...TRUNCATED) | {"pmid":"14737191","doi":"10.1371/journal.pbio.0020015","article_title":"Multiple Apoptotic Caspase (...TRUNCATED) |
PMC314300 | "Cancer invasion and metastasis have been likened to wound healing gone awry. Despite parallels in c(...TRUNCATED) | "# Introduction\n\nSince the classic observations of the many histologic similarities between the tu(...TRUNCATED) | {"pmid":"14737219","doi":"10.1371/journal.pbio.0020007","article_title":"Gene Expression Signature o(...TRUNCATED) |
PMC314464 | "Liver infection is an obligatory step in malarial transmission, but it remains unclear how the spor(...TRUNCATED) | "# Introduction\n\nMalaria is one of the most devastating infectious diseases in the world, killing (...TRUNCATED) | {"pmid":"14737184","doi":"10.1371/journal.pbio.0020004","article_title":"Cell-Passage Activity Is Re(...TRUNCATED) |
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PMC Large
PMC Large is a cleaned text dataset derived from PMC Open Access articles with permissive licenses.
Each row contains a PMC identifier, cleaned abstract, cleaned article body text, and metadata fields including PMID, DOI, article title, journal title, electronic publication date, authors, article type, and license kind.
The metadata.epub field is stored as a string because source values can be full dates such as 2003-08-18, year-month values, year-only values such as 2006, or null.
Data Fields
pmcid: PMC ID string.abstract: Cleaned abstract text.text: Cleaned body text.metadata.pmid: PubMed ID, when available.metadata.doi: DOI, when available.metadata.article_title: Article title.metadata.journal_title: Journal title.metadata.epub: Publication date string from source metadata.metadata.authors: List of author names.metadata.article_type: Article type.metadata.license_kind: Source license label.
Splits
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