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0.53244
e9a8ec352ef64596b75bfc97846c7571
Total Smoke Production versus time for all the samples.
PMC10007242
polymers-15-01093-g017.jpg
0.459282
4507280eeb8941a29597d4f60153cc32
Flowchart of the preparation of phosphate containing glycerol.
PMC10007242
polymers-15-01093-sch001.jpg
0.467006
fb986fa18ccb42c8ba6f8a3d4ac32ebe
Flowchart of the preparation of phosphate containing glycerol.
PMC10007242
polymers-15-01093-sch002.jpg
0.498427
5bf2abe22bc948d4952b96543e14ee40
Flowchart of the preparation of FR-containing particleboards.
PMC10007242
polymers-15-01093-sch003.jpg
0.511127
d13f09e029d742a3aee159519f1b514f
The overall framework of online hashing preserving local features and global-balanced similarity (LSOH). (a) Manifold learning preserves the structural features of newly arrived data, and obtains the hash codes of newly arrived data through Laplacian Eigenmaps (LE). (b) Learn binary codes by a balanced similarity matri...
PMC10007520
sensors-23-02576-g001.jpg
0.467784
9ec544483a7f4844858d7cefd364c2ea
Example images of CIFAR-10 dataset.
PMC10007520
sensors-23-02576-g002.jpg
0.444817
a8c4f45ce4bb4f8e97df834ab7072575
Example images of MNIST dataset.
PMC10007520
sensors-23-02576-g003.jpg
0.417887
1dccfc267c4e4ad99ab85c5e9ec8b1a8
Example images of Places205 dataset.
PMC10007520
sensors-23-02576-g004.jpg
0.535143
c43092014b4044a9948b4c40b2c9987b
Comparisons of Precision@K curves on CIFAR-10.
PMC10007520
sensors-23-02576-g005.jpg
0.512728
bc59718ebfab40788a44626f795bb49b
Comparisons of Precision@K curves on MNIST.
PMC10007520
sensors-23-02576-g006.jpg
0.418587
e583809373f14b9f8cb7e594e9010400
PR curve under 32-bit hash codes. (a) PR curve on CIFAR-10 (b) PR curve on MNIST.
PMC10007520
sensors-23-02576-g007.jpg
0.488653
b524540717ee453abe9f414537ee0bc8
Comparisons of mAP(@1000) performances concerning varying values of αt, βt, γt when the hashing bit is 32.
PMC10007520
sensors-23-02576-g008.jpg
0.553429
b58aabc892ba4e28b22df6d6782840b5
X-ray diffractogram patterns with their corresponding Rietveld refinements of ZnO-Pure, ZnO-La, ZnO-Ce and ZnO-LaCe NPs performed on the MAUD software. Note: *, Secondary peaks.
PMC10009547
gr1.jpg
0.406014
66e0171be10a468d9562184be42a717a
TEM images of (a) ZnO-Pure (Al Bitar et al., 2022), (b) ZnO-La, (c) ZnO-Ce and (d) ZnO-LaCe NPs. The inset of (a) shows the average particle size distribution histogram for ZnO-Pure sample (Al Bitar et al., 2022). The specified scales (a) 50 nm, (b)100 nm, (c) 50 nm, and (d) 100 nm.
PMC10009547
gr2.jpg
0.487475
51c5a434b66f459fbfda488149929367
Photoluminescence emission spectra of ZnO-Pure (Al Bitar et al., 2022), ZnO-La, ZnO-Ce and ZnO-LaCe NPs.
PMC10009547
gr3.jpg
0.399608
17c7fae431c647818adaccbb090b1efe
Inhibitory effect of ZnO-Pure (Al Bitar et al., 2022), ZnO-La, ZnO-Ce and ZnO-LaCe, Ciprofloxacin, Doxycycline and Amoxicillin toward six bacteria, (a) Escherichia coli, (b) Klebsiella pneumonia, (c) Citrobacter braakii, (d) Staphylococcus haemolyticus, (e) Staphylococcus aureus, and (f) Streptococcus intermedius. Resu...
PMC10009547
gr4.jpg
0.467349
752393c0ac904ae6bc83d9962756737e
Effect of ZnO-Pure, ZnO-La, ZnO-Ce and ZnO-LaCe NPs on the cell viability of Caco-2 and HCT-116 cells. MTT assay was performed to detect the living cells after 24 or 48 h, respectively. The IC50 values were calculated after treating the cells with varying concentrations of the prepared NPs. The obtained data are repres...
PMC10009547
gr5.jpg
0.407013
1ce7d7a385624cf1865f954556244bee
Morphological changes induced by ZnO-Pure, ZnO-La, ZnO-Ce and ZnO-LaCe NPs with varying concentrations on Caco-2 and HCT-116 cells after 24–48 h using the Inverted Microscope with × 200 magnification with scale bar value 100 µm.
PMC10009547
gr6.jpg
0.446243
9bd67850d062439fb107c9187a9bbead
The PADMR spectrometer. (a) Lab-frame view of the PADMR spectrometer. The sample is mounted to a PCB loop antenna, inside an optical cryostat, between the pole tips of an electromagnet. The probe beam passes through the center of the RF antenna, and its intensity is measured by a photodetector. A laser is overlapped wi...
PMC10009807
jz2c03665_0001.jpg
0.424045
9e1c3d7907c5428c840663b40e9f317a
Steady-state and photoinduced absorption spectra for a TSPS-PDT film. (a) Absorption spectrum (−log(T/T0)) measured at room temperature with the experimental setup described in the text. A constant value (0.25) was subtracted to correct for scattering. The gap in the spectrum is where the notch filter absorbs. (b) The ...
PMC10009807
jz2c03665_0002.jpg
0.474892
3def8e3196f04eb3af7b560abe36931b
The PADMR spectrum of TSPS-PDT is dominated by triplet signatures. (a) Detecting at the triplet PA’s peak, the f-PADMR spectrum of a TSPS-PDT film shows three main peaks (85, 990, and 1077 MHz), corresponding to transitions within the triplet manifold, T1 (600 nm probe, 642 nm continuous pump, pump intensity ≈ 15 W/cm2...
PMC10009807
jz2c03665_0003.jpg
0.443416
631f8091ff69481a807452f216b8f185
f × λ-PADMR correlates near-IR PA with T1 MR. (a) The PADMR signal magnitude, , shows strong signals when probing the 1000 nm PA (Figure 2) and driving the TZ ↔ TY transition (642 nm pump wavelength, pump intensity ≈ 15 W/cm2, fmodRF = 2.99 kHz, temperature ≈ 5–10 K). Slight asymmetry shows that the PA and MR spectral ...
PMC10009807
jz2c03665_0004.jpg
0.465176
26b1852819a64809bedbdbc5cdaa10cf
Triplet-pair model for low-temperature TSPS-PDT films. (a) Dynamical model showing triplet-pair formation (SF), diffusion, and deactivation via singlet-channel and triplet-channel annihilation (SCA and TCA), T1 deactivation through intersystem crossing (ISC), and 1TT ⇌ 5TT equilibration (energy gaps are not to scale). ...
PMC10009807
jz2c03665_0005.jpg
0.450119
9c5acb18677443dbad66041847086604
PRISMA Flow Diagram for Selection Eligible Study
PMC10009940
12889_2023_15321_Fig1_HTML.jpg
0.426146
da29cd7ee7b54a238de75e2d269244d7
Oviposition distribution, natural variation, and the relationship between plant size in oviposition preference by P. rapae butterflies on Arabidopsis accessions. (A) Heatmap showing the average number of eggs deposited per plant in the respective plots over seven independent experiments. The position of the cage is ind...
PMC10010613
erac501f0001.jpg
0.420534
a7fff572f60a4ff8981bc6a7d3cbdaca
GWAS and fine mapping results for oviposition preference of P. rapae on 346 Arabidopsis accessions. (A) Manhattan plot (grey and dark grey) showing the –log10(p) values of the SNP–trait associations from the GWAS results on Arabidopsis chromosomes 1–5 (x-axis). Narrow sense heritability was estimated to be very low (h2...
PMC10010613
erac501f0002.jpg
0.384467
430c916a033c442493df16d215f1b901
Amino-acid changes confirm possible altered gene function of fine mapping candidates. Manhattan plots of fine mapping results (MAF>5%, FDR-corrected) for the candidate genes AT3G25760 and AT4G04450, including both introns and exons or only exons. y-Axes show the –log10(p) and the x-axes the position in base pairs (bp)....
PMC10010613
erac501f0003.jpg
0.405448
83ee0adecb224d789baba1c17380aa74
Oviposition choice assay on fine-mapping confirmed genes. Six mutants, including a MYC-triple mutant (myc234) that lacks glucosinolates and a JA lacking mutant (aos) control, a T-DNA insertion line (wrky42) and an RNAi line (AOC::RNAi line 16-1) were tested for oviposition preference by P. brassicae in a two-plant choi...
PMC10010613
erac501f0004.jpg
0.487239
2e0d905ffeb543aeaca907620025aded
Caterpillar performance on mutant wrky42. Graph showing the average caterpillar weight in grams along with standard error (±SE) of mean error bars in a no-choice test. Caterpillar weight was measured after placing one L1 P. brassicae caterpillar on either a mature wild-type Col-0 plant (n=13) or a wrky42 mutant plant (...
PMC10010613
erac501f0005.jpg
0.446533
b5c3dcc994da4005b35d94a41b9f981d
Axial magnetic resonance imaging revealing cerebellar and pontine volume loss with crossed hyperintensity of the pons, known as “hot cross bun sign.”
PMC10010663
ajpmr-102-e54-g001.jpg
0.465757
cc5e280ac30447388db3b7de12e2b265
Distribution of aldosterone synthase (CYP11B2) and LHCGR in the patient’s adrenal. (A), Distribution of CYP11B2 immunoreactivity in the tumor region (T) of the adrenal tissue. (B-E), Distribution of CYP11B2 (B, D) and LHCGR (C, E) immunoreactivities in consecutive sections of the APA tissue at low (B, C) and high (D, E...
PMC10011616
fendo-14-1153374-g001.jpg
0.417997
2e2e5ecfea504ce9b2937a65d0d8fd9d
Diagram 1. Overview of shared pathophysiology and differential outcomes of DM and frailty.
PMC10012063
fcdhc-03-895313-g001.jpg
0.392325
8b08839f7cfe4f7a90a8cb18ba6c7f8e
Histogram of all CGM measurements. Abbreviation: CGM, continuous glucose monitoring.
PMC10012361
10.1177_19322968211059547-fig1.jpg
0.435041
8f35fe07c3e4476b802922fcf7b7847e
Pairwise scatterplots, distribution and linear correlation coefficients of the investigated metrics. Distribution of each metric can be found in the main diagonal, pairwise correlation coefficients in the upper right triangle and their pairwise scatterplots in the bottom left half. The 9 highest risk patients according...
PMC10012361
10.1177_19322968211059547-fig2.jpg
0.440346
059dc01dbeee425bb2b6ca10de8cbad3
Histograms of CGM measurements of the patients with the highest risk. Abbreviation: CGM, continuous glucose monitoring.
PMC10012361
10.1177_19322968211059547-fig3.jpg
0.429115
f9a5a8e25a5444ec9c89b027ef41d7af
The effect of BMI on the distribution of the hourly maximum blood glucose. Abbreviation: BMI, Body Mass Index.
PMC10012361
10.1177_19322968211059547-fig4.jpg
0.428143
6ae663f327d0486d8297d451b1eacebb
Impact of upper saturation level (trimming) on traditional GV metrics and metrics based on EVS. Values obtained with the given upper saturation level were divided with the original value (i.e., when only the physical 400 mg/dl saturation level was in effect). Abbreviations: CONGA, continuous net overall glycemic action...
PMC10012361
10.1177_19322968211059547-fig5.jpg
0.485342
857420b3baa3457ba31ac2df46a01b66
Kaplan-Meier curves for A, local failure-free survival; B, distant metastasis-free survival; C, progression-free survival; and D, overall survival in patients in the retrospective clinical cohort with an on-treatment mANC ≤ 5,000 cells/µL vs mANC > 5,000 cells/uL. HR, hazard ratio; mANC, mean absolute neutrophil count.
PMC10014332
gr1.jpg
0.371656
d3b6d05ee3c547e6afdae0d5547f3af8
Circulating and tumor-associated myeloid cells during Chemoradiotherapy. A and B, CD11b+CD11c- cells in PBMC (A) and tumor cytobrush (B) samples. C, Scatterplot showing a correlation between cytobrush and PBMC CD11b+CD11c- samples. The black regression line formula and R2 refer to the overall population of samples, whi...
PMC10014332
gr2.jpg
0.464479
f75773088eaf4da49fad8e893d836024
Flow diagram for the identification and exclusion of studies. MNI, Montreal Neurological Institute; DMN, default mode network.
PMC10014826
fnins-17-1136790-g001.jpg
0.420611
0473b8d323f74bd881f2a4af4bfad5ba
The areas of increased (red) and decreased (blue) functional connectivity (FC) in the main meta-analysis. “R” and “L” denote the right and left sides of the brain, respectively. The color bar indicates the maximum and minimum seed-based d mapping (SDM)-Z value.
PMC10014826
fnins-17-1136790-g002.jpg
0.451328
7116d1ffd9224968911a21ce8aadcc3c
Initial subcutaneous calcium deposits along the length of right arm. At initial development, these findings followed the same path of the catheter used for parenteral nutrition and as such, a local reaction to an extravasation was firstly hypothesized.
PMC10015177
gr1.jpg
0.42364
c389e3c9757845bdb02def67ffe8c76e
Evolution of the calcifications along the right arm 4 months from the previous photograph. The lesion became more extensive both clinically and radiologically, prompting histological and genetic analysis. No surgical management had been performed by this stage.
PMC10015177
gr2.jpg
0.467684
6ad1847e9990477bab8a6523643b75f3
Map of the survey sites, in their respective maize agroecological zones.
PMC10015270
gr1.jpg
0.431466
b1d68652785d4894a6b2a1a923c1bc18
Trends in the adoption of improved maize varieties (IMV) in Kenya from 1992 to 2013, in adoption rate (% of farmers adopting IMVs) and adoption intensity (% of maize area in IMVs) (error bars represent standard errors).
PMC10015270
gr2.jpg
0.380338
360621efb8e34e70acceabb58cf2ce79
Area share of maize varieties, by source and over time.
PMC10015270
gr3.jpg
0.502314
c047ea83c99a4722ae7e8429849509cf
Area share of different types of maize varieties by source and agroecological zone, over time.
PMC10015270
gr4.jpg
0.451111
1880990eab114f84943de38a944b578a
Trends in weighted average age (years) of maize varieties, for all varieties and for improved varieties only.
PMC10015270
gr5.jpg
0.462601
19cc1e47b49b4bde84200671a59afa02
Trends in weighted average age (WAA, in years) of maize varieties, all varieties and improved varieties alone, by agroecological zone.
PMC10015270
gr6.jpg
0.45515
66b78e48153c4c5ca3008a791f73224b
Scalp psoriasis status measured using the Scalp Physician Global Assessment (Scalp-PGA) at baseline and after 4 weeks' treatment with Cal/BD aerosol foam (n = 193); Scalp-PGA was assessed with the three categories “mild/moderate/severe” [5], with the category “mild” being the lowest possible category to rank, thus also...
PMC10015748
drm-0239-0206-g01.jpg
0.413156
08171fdd26324c6994cd69caa566cd42
Severity of scalp psoriasis during the course of the 4-week study measured using the scalp psoriasis patient global assessment (Scalp-PaGA, 0 = clear, 5 = very severe; n = 193; LOCF; mean ± SD); *p < 0.001 versus baseline.
PMC10015748
drm-0239-0206-g02.jpg
0.379295
31ccd01852ba4a00af55ec1cedde7bda
Severity of scalp psoriasis during the course of the 4-week study measured using the scalp psoriasis patient global assessment (Scalp-PaGA) (n = 193).
PMC10015748
drm-0239-0206-g03.jpg
0.381592
816971f419a64c6f815bda0b646ecf20
Patient reported perception of itch on the affected scalp rated using a NRS ranging from 0 = no itch to 10 = maximum itch at baseline and after 4 weeks of treatment with Cal/BD aerosol foam (n = 194).
PMC10015748
drm-0239-0206-g04.jpg
0.409992
36b4a95ea5ca482198b847bad8069745
Influence of scalp psoriasis on the QoL of patients measured using Dermatology Quality of Life Index (DLQI) at the start of therapy and end of study following 4 weeks' treatment with Cal/BD aerosol foam (n = 186).
PMC10015748
drm-0239-0206-g05.jpg
0.459242
34dea35184004fb7807d6e2d40d79822
Patient reported perception of Cal/BD aerosol foam feeling on the skin at day 3 (each category rated using a 5-point scale ranging from “very strong” to “not at all”).
PMC10015748
drm-0239-0206-g06.jpg
0.45185
71087fe96f7542feaca62d5cc13e9404
Hypoxia-associated circRNA profiling and expression characteristics of Hsa_circ_0000566 in osteosarcoma (OS). (A) CircRNA microarray analysis reveals 35 upregulated and 23 downregulated circRNAs in OS cells under normoxic and hypoxic conditions. The black arrow represents Hsa_circ_0000566. (B) OS cells incubated under ...
PMC10017158
AD-14-2-529-g1.jpg
0.441668
0b713e2ebd174309b9896e5dab0dbbc1
Hsa_circ_0000566 contributes to in vitro osteosarcoma (OS) cell progression under hypoxic conditions. (A) Hsa_circ_0000566 overexpression and knockdown induced and repressed OS cell proliferation under hypoxia. Results are reported as mean ± standard deviation (SD), *p < 0.05, n = 3. Circ_0000566 represents Hsa_circ_00...
PMC10017158
AD-14-2-529-g2.jpg
0.457455
9f338c314e5641cabf9cdea6cfa20577
Hsa_circ_0000566 accelerates osteosarcoma (OS) glucose metabolism and regulates hypoxia-enhanced glycolysis. (A) Colors of the media indicate that Hsa_circ_0000566 silencing decreased lactate accumulation under hypoxia. (B-C) Quantitative real-time polymerase chain reaction (qRT-PCR) or western blots evaluating the exp...
PMC10017158
AD-14-2-529-g3.jpg
0.480262
19898175fbe842adb63973a82fd3e667
Hsa_circ_0000566 establishes interactions with HIF-1α and confers protection against ubiquitination-mediating degradation. (A) Effects of Hsa_circ_0000566 knockdown and Hsa_circ_0000566 overexpression on mRNA and protein expression in 143B and HOS cells under hypoxia. Results are reported as mean ± standard deviation (...
PMC10017158
AD-14-2-529-g4.jpg
0.438636
39d8698940dd48428b3959179825d5bf
Hypoxia-induced Hsa_circ_0000566 stabilizes HIF-1α by attenuating interactions between Von Hippel—Lindau (VHL) and HIF-1α. (A) The interaction between VHL and Hsa_circ_0000566, assessed by performing a RIP assay. Results are reported as mean ± standard deviation (SD), *p < 0.05, n = 3. (B) Interaction between VHL and H...
PMC10017158
AD-14-2-529-g5.jpg
0.41502
d22fd747ab9c47e6a4d5df5cea71527c
HIF-1α overexpression reverses Hsa_circ_0000566 silencing-induced attenuation of osteosarcoma (OS) cell proliferation, migration, and glucose metabolism. (A) Hsa_circ_0000566 silencing in OS cells inhibits LDHA enzyme activity, whereas HIF-1α overexpression promotes enzyme activity. (B-C) Quantitative real-time polymer...
PMC10017158
AD-14-2-529-g6.jpg
0.477065
d44444456f3d4f9a8764cf5638430e68
HIF-1α targets and regulates Hsa_circ_0000566 in glycolysis under hypoxic stress. (A-B) Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting demonstrates that among vital transcription factors such as HIF-1α, HIF-2α, p53, and Hsa_circ_0000566, only Hsa_circ_0000566 is induced by HIF-1α under ...
PMC10017158
AD-14-2-529-g7.jpg
0.392291
73e6ccf672ca4fa1b0aeb37f1747e318
Hsa_circ_0000566 promotes osteosarcoma (OS) glucose metabolism and tumorigenesis progression in vivo. (A) 143B cells stably transfected with Hsa_circ_0000566 knockdown, HIF-1α overexpression, or empty vector plasmids. Nude mice were subcutaneously injected with 1 × 107 cells that were either stable negative controls or...
PMC10017158
AD-14-2-529-g8.jpg
0.43418
bccd2fcddfb8419c826352ad7867f5be
Characteristics of three-dimensional fluorescence spectra.
PMC10017222
CIN2023-7535594.001.jpg
0.419517
c794dc395d6143148b2dd73154bbe641
The neuronal structure.
PMC10017222
CIN2023-7535594.002.jpg
0.445836
d67cc27b03fe4299b1a8ff49a71cc9f3
The deep learning model.
PMC10017222
CIN2023-7535594.003.jpg
0.4195
ca784e66025b420584d8078e4cd88cf8
Main properties of biochar.
PMC10017222
CIN2023-7535594.004.jpg
0.464254
07947efe72d543a98489c1771e59810e
Effects of different chemical fertilizers on the content of water-soluble organic matter in the soil at 0∼60 cm depth.
PMC10017222
CIN2023-7535594.005.jpg
0.461193
059c840a82564818bc788b36a6fdb799
Three-dimensional fluorescence spectra of water-soluble organic matter after 6 years of fertilization (I tyrosine-like substance; II: tryptophan-like substance; III: fulvic acid-like substance; IV: soluble microbial by-products; V: humic acid-like substance): (a) no fertilizer; (b) NPK; (c) BC; (d) NPK + BC; (e) N + BC...
PMC10017222
CIN2023-7535594.006.jpg
0.470748
0538c6b524764561acff55bc6322d1d6
Results of different fluorescent components (C1: humic acid-like substance; C2: fulvic acid-like substance; C3: protein-like substance): (a) CK; (b) NPK; (c) BC; (d) NPK + BC; (e) N + BC.
PMC10017222
CIN2023-7535594.007.jpg
0.475009
89e8059dd7924795be57aeb5ffb3166d
Different FIs in the whole soil depth:(a) FI; (b) HIX; (c) BIX. T0: no fertilizer; T1: NPK; T2: BC; T3: BC + NPK; T4: BC + N.
PMC10017222
CIN2023-7535594.008.jpg
0.411436
f4ad1be2d0654ca5a0d425e8038ade46
Pericytes and mesenchymal stromal cells in vivo and in vitro. The upper left portion of the figure shows a schematic representation of a portion of a tissue, where a small blood vessel formed by endothelial cells is surrounded by vascular smooth muscle cells at the arteriole level, and by different types of pericytes, ...
PMC10017474
fcell-11-1148121-g001.jpg
0.510297
5705642011e246cc9775f25738c81cf4
A SEM images of the synthesized organosilica particles PMO-OH at 50k of magnification (inset: 200k of magnification). B Size distribution by volume (H2O, 25°C) of PMO-OH nanoparticles measured by hydrodynamic light scattering (DLS)
PMC10017643
604_2023_5679_Fig1_HTML.jpg
0.427607
8a00bb47fbed460c93c24de9ac0ebd65
SEM images of the reactive side of POM@PMO-PE sensor before phosphate detection using different scales and orders of magnitudes A ×250, B ×5k, and C ×50k showing the embedment of PMOs nanoparticles in between carbon graphite micro-flakes and D corresponding EDX spectra
PMC10017643
604_2023_5679_Fig2_HTML.jpg
0.488366
cc53815a4f754b12821f8dcb498c4904
Comparison between the anodic SWV response POM-PE and POM@PMO-PE in 1M H2SO4 prepared in KCl 0.1M (black-dashed curves) and after adding 10nM of phosphate as NaH2PO4 (solid curves)
PMC10017643
604_2023_5679_Fig3_HTML.jpg
0.400155
6d2dee506bab485e98a9f4738e59ca19
A Anodic SWV response of activated POM@PMO-PE sensors upon successive additions of aqueous H2PO4− standards prepared in 1M H2SO4/0.1M KCl (blank) to obtain increasing concentrations 1–500nM. B Calibration curves were obtained based on the relative variation of the maximum peak intensity corrected by subtracting any bla...
PMC10017643
604_2023_5679_Fig4_HTML.jpg
0.443837
a70a5f9600a1418f98a1b92cca5b7659
Anodic SWV response of activated POM@PMO-PE sensors toward two different concentrations of phosphate and silicate as a potential interferent. The error bars are the RSD of three independent measurements (n=3)
PMC10017643
604_2023_5679_Fig5_HTML.jpg
0.429852
8487803bc32747428fc720f2bd801990
Experimental procedure for periodic mesoporous organosilica (PMO) preparation starting from CTAB [Created with BioRender.com].
PMC10017643
604_2023_5679_Sch1_HTML.jpg
0.420724
77a1520775444b9cb7a30a358df8c678
Flow diagram of cohort study population
PMC10017785
464_2022_9670_Fig1_HTML.jpg
0.403017
194078bac3c64bbab295f9cafcbab497
Signaling network of the IL-2 cytokine family. Receptors of IL-2, IL-15, IL-21, IL-4, IL-7 and IL-9 share a common γ chain subunit. They phosphorylate various STAT proteins downstream by activating JAK/STAT signaling pathway.
PMC10018032
fimmu-14-1090311-g001.jpg
0.451662
1470b34c5f7c48c49a4950ee0205800b
Representative engineering cytokine patterns.
PMC10018032
fimmu-14-1090311-g002.jpg
0.418237
d1e599d155e94327a40dbbdf283a04c7
Patient flow diagram. CGI-I, Clinical Global Impression-Improvement; eCRF, electronic case report form; IRB, institutional review board.
PMC10018127
fpsyt-14-1075939-g001.jpg
0.52226
e11ea66ddd7244a8a281c84c50df3118
Mean weight at baseline, Visit 2 and Visit 3. Error bars represent standard deviations.
PMC10018127
fpsyt-14-1075939-g002.jpg
0.439152
008681b8d9884d8b8fb98cf67cebf698
Change in MADRS total score from baseline. The mean MADRS total score at Visit 1 was based on all patients, not just those that also had data at Visit 2 or Visit 3, however, when analyzing the difference between the visits (Visit 1 to Visit 2 and Visit 1 to Visit 3), scores of patients who had scores at both visits wer...
PMC10018127
fpsyt-14-1075939-g003.jpg
0.445159
776807acda8440df935349c99f188bfa
Effectiveness using CGI-I assessment. Effectiveness of vortioxetine was defined as the proportion of patients that showed improvements in CGI-I scores from baseline at Visits 2 (8±2 weeks) and 3 (24±2 weeks). Effectiveness was calculated by classifying “Improved” categories as “effective”, and categories under “No chan...
PMC10018127
fpsyt-14-1075939-g004.jpg
0.449216
74792b6895e94f008b216b11b5a6e4e9
Change in PDQ-K total score from baseline. The mean PDQ-K total score at Visit 1 was based on all patients, not just those that also had data at Visit 2 or Visit 3, however, when analyzing the difference between the visits (Visit 1 to Visit 2 and Visit 1 to Visit 3), scores of patients who had scores at both visits wer...
PMC10018127
fpsyt-14-1075939-g005.jpg
0.448698
ee7d842decf64d6c99c44be9aadefe63
Change in DSST total score from baseline. The mean DSST total score at Visit 1 was based on all patients, not just those that also had data at Visit 2 or Visit 3, however, when analyzing the difference between the visits (Visit 1 to Visit 2 and Visit 1 to Visit 3), scores of patients who had scores at both visits were ...
PMC10018127
fpsyt-14-1075939-g006.jpg
0.506545
7e6119e5f26542d592fdfe26ad346438
Pressure-volume loop demonstrating the phenomenon of “beaking.” A typical pressure-volume loop generated from ventilation of an optimally-expanded lung (solid line) is shown for reference. Note that in the normal condition, a relatively small change in pressure results in a significant change in volume. Excessive posit...
PMC10018229
fped-11-1087857-g001.jpg
0.50015
e89a134ce1884b33b8701ca0c05a8605
Ventilator data flowsheet encompassing 18–21 days of age for a former 27 week, 1,160 gram premature infant with evolving chronic lung disease and supported on pressure-regulated volume control ventilation. As exhaled tidal volume (open diamonds) exceeds the set tidal volume (open circles) (asterix), note that the venti...
PMC10018229
fped-11-1087857-g002.jpg
0.438233
1c96185299204cdfb2700477107a0f3d
Chest computed tomography of an 8 month old former 26 week premature infant with severe BPD demonstrating dramatic pulmonary heterogeneity with alveolar simplification of the right upper lobe and diffuse fibrosis of the left lung. The patient is also severely hyperinflated with flattened diaphragms.
PMC10018229
fped-11-1087857-g003.jpg
0.434285
cbeb02f5212c4274ab0d7a0475246c42
Ventilator waveforms from a 2 month old former 24 week premature infant with severe bronchopulmonary dysplasia using two different PEEP strategies. On physical exam, the child has a respiratory rate of 26 breaths/min. A) However, using a PEEP 10 cm H2O, he has multiple failed triggers (yellow circles) and does not appe...
PMC10018229
fped-11-1087857-g004.jpg
0.422995
e9357b33a7e24650a6777fadaef5176c
Ventilator waveforms from an 8 month old former 24 week premature infant with severe bronchopulmonary dysplasia using two different inspiratory time strategies. (A) Using a short (0.4 s) inspiratory time, there is incomplete filling (white arrows) with reduced tidal volume (yellow arrows), increased respiratory rate, a...
PMC10018229
fped-11-1087857-g005.jpg
0.467656
666df9bca3ed494ea2674bfa1e0313e9
Nuclear RAGE interacts with the DNA replication helicase complex subunits Mcm2/7. (A) Schematic representation of the steps used for identifying the interacting partners of RAGE in the nucleus from HEK293T cells left untreated (UT) or treated with the replication stress agent hydroxyurea (HU; 2 mM for 4 h). (B) Silver-...
PMC10018352
gkad085fig1.jpg
0.514499
8594f1652070418197a2ac30654c7516
Role of RAGE in faithful progression of the replication fork and its stability under basal conditions or replication stress. The scheme shows the cellular response to the replication stress in the presence or absence of RAGE. The perturbed homeostasis and failure to resolve the replication errors may play a role in var...
PMC10018352
gkad085fig10.jpg
0.446161
433cfb48eeaf47b095aa71307c198491
Replication stress promotes the recruitment of RAGE into the miniature-chromosome complex. (A) The quantitative analysis showing the Mander's colocalization coefficient for the RAGE/Mcm2 or RAGE/Mcm7 colocalization of the data presented in Supplementary Figure 3A. Data represents mean ± SEM, **P < 0.01; ***P < 0.001, n...
PMC10018352
gkad085fig2.jpg
0.403106
fc2e4c1290b94cd891787aea1d0f7329
Absence of RAGE sensitizes the faithful progression of the replication fork under stress situation. (A) Representative images of the colonies from WT or RAGE−/− Hela cells either left untreated (UT) or treated with HU (indicated concentrations for 4 h), showing the percentage survival potential of these cells to recove...
PMC10018352
gkad085fig3.jpg
0.415073
a80cd57e2cdd4c85846501f5f4df76b2
Under replication stress situations, RAGE prevents the expression of 53BP1 in OPT domain and the appearance of micronuclei. (A) Representative immunofluorescence images showing a comparative analysis of HU stress repair potential, as evidenced by single large 53BP1 foci, as marked by yellow arrowheads, in WT or RAGE−/−...
PMC10018352
gkad085fig4.jpg
0.416765
35a406e76258498a9525748be1b3b161
RAGE stabilizes the levels of Mcm2 under replication stress. (A) Schematic presentation of the steps involved in Cycloheximidine (CHX) pulse-chase experiment in Hela RAGE−/− cells transfected with a plasmid expressing mCherry alone or the mCherry-RAGE. The samples were collected at 0, 1, 3 and 6 h. (B) Representative i...
PMC10018352
gkad085fig5.jpg
0.440078
556512fc99f04153bad3159e7f489e78
Absence of RAGE affects the integrity of ciliated zones and modulates the buildup of ECM. (A) Representative images of renal sections obtained age-matched controls versus non-diabetic (3 months old) or 7-week diabetic (STZ) WT and RAGE−/− mice, stained for ciliated zone marker α-acetylated-tubulin (in red). The areas m...
PMC10018352
gkad085fig6.jpg
0.454519
734bcaeaeaeb49a395e412127542dc1f
RAGE and Mcm2 participate in the same pathway to counter the replication stress. (A) Quantitative analysis showing the percentage survival potential of untreated (UT; black bars) and hydroxyurea treated (HU; 2 mM, 4 h; grey bars), Mcm2 depleted WT or RAGE−/− HeLa cells as described in Supplementary Figure 20B. Data rep...
PMC10018352
gkad085fig7.jpg