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Instruct:
Identify the main category of Biorxiv papers based on the titles
Query:
DNA supercoiling-mediated collective behavior of co-transcribing RNA polymerases | biophysics |
Instruct:
Identify the main category of Biorxiv papers based on the titles and abstracts
Query:
Extracellular prostaglandins E1 and E2 and inflammatory cytokines are regulated by the senescence program in potentially premalignant oral keratinocytes
Potentially pre-malignant lesions (PPOLs) are composed of keratinocyte... | cell biology |
Instruct:
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Query:
Modeling microRNA-driven post-transcriptional regulation by using exon-intron split analysis (EISA) in pigs | genomics |
Instruct:
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Query:
Synaptotagmin-7 enhances phasic dopamine release
Dopamine released from substantia nigra pars compacta (SNc) neurons modulates movement, motivation, and reward. In addition to their tonic firing pattern, dopamine neurons al... | neuroscience |
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Query:
Effects of long-lasting insecticide net (LLINs) ownership/utilisation indicators on annual household malaria episodes (AHMEs) in three Health Districts in Cameroon | epidemiology |
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Query:
The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues
Desminopathies comprise hereditary myopathies and cardiomyopathies caused by mutations in the intermediate filament... | biophysics |
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Query:
Zebrafish caudal fin amputation induces a metabolic switch necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration | developmental biology |
Instruct:
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Query:
Direct cochlear recordings show human hearing nerve activity is modulated by selective attention
The architecture of the efferent auditory system enables prioritization of strongly overlapping spatiotemporal cochlear activa... | neuroscience |
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Query:
Robust Characterization of Non-Invasive Post-Traumatic Osteoarthritis Mouse Model | animal behavior and cognition |
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Query:
Electric shock causes fear-like persistent behavioral response in the nematode Caenorhabditis elegans
Behavioral persistency reflects internal brain states, which are the foundations of multiple brain functions. However, ex... | neuroscience |
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Query:
The evolution of widespread recombination suppression on the Dwarf Hamster (Phodopus) X chromosome | genomics |
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Query:
Rap-Phr systems in B. subtilis 3610 affect matrix gene expression and play a role in biofilm formation in vitro and on the plant root
Natural isolates of the soil-dwelling bacterium Bacillus subtilis form robust biofilms un... | microbiology |
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Query:
Parent-Child Autonomic Synchrony During Vicarious Extinction Learning in Pediatric PTSD | neuroscience |
Instruct:
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Query:
A Web Portal and Workbench for Biological Dissection of Single Cell COVID-19 Host Responses
Numerous studies have provided single-cell transcriptome profiles of host responses to SARS-CoV-2 infection. Critically lacking how... | immunology |
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Query:
Development of methods for purification of individual biological active substances obtained from extracts of Hedysarum neglectum | plant biology |
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Query:
A multivariate view of cognitive performance reveals positive correlation in the Trinidadian Guppy (Poecilia reticulata)
Cognitive variation is common among-individuals and can be consistent across time and context. From an... | animal behavior and cognition |
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Query:
Systems analysis of metabolic responses to a mixed meal test in an obese cohort reveals links between tissue metabolism and the gut microbiota | systems biology |
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Query:
SARS-CoV-2 B.1.617.2 Delta variant emergence and vaccine breakthrough
The SARS-CoV-2 B.1.617.2 (Delta) variant was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-exis... | microbiology |
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Query:
A Multisite and Multimodal Comparative Study of Cerebellar Connectome Between Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders | neuroscience |
Instruct:
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Query:
Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative
The Receptor Binding Domain (RBD) of SARS-CoV-2 is the primary target of neutralizing antibodies. We ... | microbiology |
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Query:
A Massively Parallel Trafficking Assay Accurately Predicts Loss of Channel Function in KCNH2 Variants | biophysics |
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Query:
Synapses learn to utilize pre-synaptic noise for the prediction of postsynaptic dynamics
Synapses in the brain are highly noisy, which leads to a large trial-by-trial variability. Given how costly synapses are in terms of e... | neuroscience |
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Query:
Non-coding RNAs Associated with Prader-Willi Syndrome Regulate Transcription of Neurodevelopmental Genes in Human Induced Pluripotent Stem Cells | molecular biology |
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Query:
Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome
A loss of the checkpoint kinase ATM leads to impairments in the DNA damage r... | molecular biology |
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Query:
Effects of diversifying the planting period of maize on herbivorous and their natural enemies | ecology |
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Query:
Detecting intragenic trans-splicing events with hybrid transcriptome sequencing in cancer cells
Trans-splicing can generate non-co-linear (NCL) transcripts that consist of exons in an order topologically inconsistent with t... | bioinformatics |
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Query:
A digitization theory of the Weber-Fechner law | neuroscience |
Instruct:
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Query:
HALO: A software tool for real-time head alignment in the MR scanner
Magnetic resonance imaging (MRI) studies in human subjects often require multiple scanning sessions/visits. Changes in a subjects head position across ses... | neuroscience |
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Query:
scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks | bioinformatics |
Instruct:
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Query:
The role of migration in mutant evolution in fragmented populations
Mutant evolution in fragmented populations has been studied extensively in evolutionary biology. With an increased focus on evolutionary dynamics in medica... | evolutionary biology |
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Query:
Machine learning prediction of antiviral-HPV protein interactions for anti-HPV pharmacotherapy | bioinformatics |
Instruct:
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Query:
Rationally designed immunogens enable immune focusing to the SARS-CoV-2 receptor binding motif
Eliciting antibodies to surface-exposed viral glycoproteins can lead to protective responses that ultimately control and prevent... | immunology |
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Query:
Guided Axon Outgrowth of Neurons by Real-Time Femtosecond Laser Penetration on a 4 μm Thick Thin-Glass Sheet | bioengineering |
Instruct:
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Query:
Plasmids as donors of Insertion Sequence elements mediating colistin resistance in Klebsiella pneumoniae
Colistin is a last resort antibiotic for the treatment of carbapenemase producing Klebsiella pneumoniae (CRKP). In lin... | microbiology |
Instruct:
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Query:
On the generalizability of diffusion MRI signal representations across acquisition parameters, sequences and tissue types: chronicles of the MEMENTO challenge. | neuroscience |
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Query:
The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance
Streptococcus pyogenes is a globally prominent human-specific pathogen responsibl... | microbiology |
Instruct:
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Query:
Impact of maternal protein restriction on hypoxia-inducible factor (HIF) expression in male fetal kidney development | developmental biology |
Instruct:
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Query:
Discovering fragment length signatures of circulating tumor DNA using Non-negative Matrix Factorization
Sequencing of cell-free DNA (cfDNA) is currently being used to detect cancer by searching both for mutational and non-m... | bioinformatics |
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Query:
Mitonuclear interactions produce extreme differences in response to redox stress | biochemistry |
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Query:
A cell type-specific multiomics uncovers a guard cell-specific RAF15-SnRK2.6/OST1 kinase cascade
Multicellular organisms such as plants contain different cell types with specialized functions. Analyzing the characteristics ... | plant biology |
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Query:
Down Regulation Of IL-1β Secretion By TGF-β1 In Macrophages Infected With Dengue Virus | immunology |
Instruct:
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Query:
Function-structure Coupling:White matter fMRI hyper-activation associates with structural integrity reductions in schizophrenia
BackgroundWhite matter (WM) microstructure deficit may be an underlying factor in the brain dys... | neuroscience |
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Query:
A Herpes Simplex Virus Type-1-derived influenza vaccine induces balanced adaptive immune responses and protects mice from lethal influenza virus challenge. | microbiology |
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Query:
Paf1C denoises transcription and growth patterns to achieve organ shape reproducibility
In multicellular systems, all cells exhibit transcriptional noise. However, its exact contribution to morphogenesis often remains uncle... | developmental biology |
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Query:
Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome | neuroscience |
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Query:
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU+ CAF expression with HSF1 signaling
Cancer-associated fibroblasts (CAFs) give rise to desmoplastic stroma, which supports tumor pro... | cancer biology |
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Query:
Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye | evolutionary biology |
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Query:
Distinct REV-ERBα Conformational State Predicted by GaMD Simulations Leads to the Structure-Based Discovery of Novel REV-ERBα Antagonist
REV-ERB is a nuclear hormone receptor that plays important role in the regulation of m... | biophysics |
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Query:
Tom70-based transcriptional regulation of mitochondrial biogenesis and aging | cell biology |
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Query:
Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae
Species of the mustelid subfamily Guloninae inhabit diverse habitats on multiple continents, and occupy a variety of ecol... | evolutionary biology |
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Query:
Topography-dependent gene expression and function of common cell archetypes in large and small porcine airways | genomics |
Instruct:
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Query:
Discovery of SARS-CoV-2 Mpro Peptide Inhibitors from Modelling Substrate and Ligand Binding
The main protease (Mpro) of SARS-CoV-2 is central to its viral lifecycle and is a promising drug target, but little is known concer... | bioinformatics |
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Query:
Temporal response characterization across individual multiomics profiles of prediabetic and diabetic subjects | genomics |
Instruct:
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Query:
Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory
Hippocampal somatostatin (SOM) cells are dendrite-projecting inhibitory interneurons. CA1 SOM ... | neuroscience |
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Query:
Phase tracking algorithms detect both real and imaginary components of outer hair cell nonlinear membrane capacitance that exhibits dielectric loss. | biophysics |
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Query:
Drug-dependent morphological transitions in spherical and worm-like polymeric micelles define stability and pharmacological performance of micellar drugs
Significant advances in physicochemical properties of polymeric micel... | pharmacology and toxicology |
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Query:
Dynamic reconfiguration of macaque brain networks during free-viewing of natural scenes | neuroscience |
Instruct:
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Query:
Scarcity of hosts for gregarious parasitoids indicates an increase of individual offspring fertility by reducing their own fertility
The gregarious parasitoid strategy allows multiple larvae to complete development in a sin... | zoology |
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Query:
A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer | cancer biology |
Instruct:
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Query:
Penalized Logistic Regression Analysis for Genetic Association Studies of Binary Phenotypes
IntroductionIncreasingly, logistic regression methods for genetic association studies of binary phenotypes must be able to accommod... | genetics |
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Query:
Cortico-Subcortical Interactions in Overlapping Communities of Edge Functional Connectivity | neuroscience |
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Query:
ABCA1 causes an asymmetric cholesterol distribution to regulate intracellular cholesterol homeostasis
Cholesterol is a major and essential component of the mammalian cell plasma membrane (PM) and the loss of cholesterol hom... | cell biology |
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Query:
Arf6 is necessary for high level Wingless signalling during Drosophila wing development | developmental biology |
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Query:
Retinal input influences pace of neurogenesis but not cell-type configuration of the visual forebrain
The brain is assembled during development by both innate and experience-dependent mechanisms1-7, but the relative contrib... | neuroscience |
Instruct:
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Query:
MorphoGraphX 2.0: Providing context for biological image analysis with positional information | developmental biology |
Instruct:
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Query:
Neural Networks for self-adjusting Mutation Rate Estimation when the Recombination Rate is unknown
Estimating the mutation rate, or equivalently effective population size, is a common task in population genetics. If recombi... | evolutionary biology |
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Query:
A curated collection of human vaccination response signatures | bioinformatics |
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Query:
A DNA-based optical force sensor for live-cell applications
Mechanical forces are relevant for many biological processes, from wound healing or tumour formation to cell migration and differentiation. Cytoskeletal actin is l... | biophysics |
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Query:
Direct precise measurement of the stall torque of the flagellar motor in E. coli | biophysics |
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Query:
A Spatiotemporal Reconstruction of the C. elegans Pharyngeal Cuticle Reveals a Structure Rich in Phase-Separating Proteins
Roughly 4.5 million species of ecdysozoan animals repeatedly shed their old cuticle and construct a ... | systems biology |
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Query:
Optical activation of TrkB neurotrophin receptor in mouse ventral hippocampus promotes plasticity and facilitates fear extinction | neuroscience |
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Query:
Disruption of nucleoid expanded conformation by toxic aberrant proteins synthesized in Escherichia coli
Aminoglycoside antibiotics interfere with selection of cognate tRNAs during translation, resulting in the production of... | microbiology |
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Query:
Distinguishing between recent balancing selection and incomplete sweep using deep neural networks | evolutionary biology |
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Query:
Emergent population activity in metric-free and metric networks of neurons with stochastic spontaneous spikes and dynamic synapses
We show that networks of excitatory neurons with stochastic spontaneous spiking activity and... | neuroscience |
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Query:
DJ-1 glyoxalase activity makes a modest contribution to cellular defense against methylglyoxal damage in neurons | biochemistry |
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Query:
In amygdala we trust: different contributions of the basolateral and central amygdala in learning whom to trust
Human societies are built on cooperation and mutual trust, but not everybody is trustworthy. Research on rodent... | neuroscience |
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Query:
A possible way to relate the effects of SARS-CoV-2 induced changes in transferrin to severe COVID-19 associated diseases | biophysics |
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Query:
Optimal strategies to protect a sub-population at risk due to an established epidemic
Epidemics can particularly threaten certain sub-populations. For example, for SARS-CoV-2, the elderly are often preferentially protected.... | ecology |
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Query:
A marine fungus efficiently degrades polyethylene | microbiology |
Instruct:
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Query:
Vendor-neutral sequences (VENUS) and fully transparent workflows improve inter-vendor reproducibility of quantitative MRI
PurposeWe developed an end-to-end workflow that starts with a vendor-neutral acquisition and tested t... | bioengineering |
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Query:
In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration | developmental biology |
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Query:
Oct1 recruits the histone lysine demethylase Utx to promote lineage specification
The pathways used by cells to transition between undifferentiated, pluripotent state and tissue-specific states are incompletely understood. ... | developmental biology |
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Query:
Evolution of a costly immunity to cestode parasites is a pyrrhic victory | evolutionary biology |
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Query:
A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urg... | immunology |
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Query:
Topoisomerase 1 dependent R-loop deficiency drives accelerated replication and genomic instability | cell biology |
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Artificial mimicry of seasonal transcriptome dynamics in Arabidopsis thaliana reveals short- and long-term responses to environmental conditions
O_LIPlants must respond to various environmental factors that change seasonall... | plant biology |
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scINSIGHT for interpreting single-cell gene expression from biologically heterogeneous data | bioinformatics |
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Query:
Basal amygdala inputs to the medial prefrontal cortex mediate fear memory strengthening
Survival critically depends on the memorization of stimuli recurrently predicting pleasant or aversive experiences. Memory strengthenin... | neuroscience |
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Single-cell RNA sequencing identifies phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow | cell biology |
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Query:
Costs dictate strategic investment in dominance interactions
Dominance is important for access to resources. As dominance interactions are costly, individuals should be strategic in who they interact with. One hypothesis is... | animal behavior and cognition |
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Query:
Single-cell immune profiling reveals the impact of antiretroviral therapy on HIV-1-induced immune dysfunction, T cell clonal expansion, and HIV-1 persistence in vivo | immunology |
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Query:
Synchronic resisto-genesis effects identify most prevalent mechanism in Acinetobacter baumannii
Acinetobacter baumannii as deadliest infection agent to ICU patients challenge experimental treatment in lack of new antibiotic... | microbiology |
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Query:
Simulation-based inference of evolutionary parameters from adaptation dynamics using neural networks | evolutionary biology |
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Expectations boost the reconstruction of auditory features from electrophysiological responses to noisy speech
Online speech processing imposes significant computational demands on the listening brain, the underlying mechan... | neuroscience |
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Acute myeloid leukemia cells are targeted by the naturally occurring CXCR4 antagonist EPI-X4 | cancer biology |
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Prediction of broad chemical toxicities using induced pluripotent stem cells and gene networks by transfer learning from embryonic stem cell data
The assessment of toxic chemicals using animals has limited applicability to ... | pharmacology and toxicology |
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Query:
Real Time Face Recognition with limited training data: Feature Transfer Learning integrating CNN and Sparse Approximation | neuroscience |
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Loss of SORCS2 is associated with neuronal DNA double-strand breaks
SORCS2 is one of five proteins that constitute the Vps10p-domain receptor family. Members of this family play important roles in cellular processes linked ... | neuroscience |
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Parallel evolution of urban-rural clines | evolutionary biology |
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Nanoscopical analysis reveals an orderly arrangement of the presynaptic scaffold protein Bassoon at the Golgi-apparatus
1.Bassoon is a large, 440 kDa, scaffold protein of the specialized sites mediating neurotransmitter rel... | neuroscience |
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