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+  "title": "Open Syndrome Acute Flaccid Paralysis (AFP)",
+  "description": "Case definition for suspected polio",
+  "scope": "broad",
+  "category": "suspected",
+  "version": "1.0.0",
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+  "published_in": "https://opensyndrome.org",
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+  "published_by": [
+    "Open Syndrome Initiative"
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+  "location": "Kenya",
+  "language": "English",
+  "organization": "Ministry of Health",
+  "authors": [
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+              "description": "Weakness or floppiness of the limbs of sudden onset not due to trauma"
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+}

machine_readable/json/arbovirosis_paraguay_cd.json

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+  "description": "",
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+  "published_by": [
+    "Open Syndrome Initiative"
+  ],
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+  "language": "English",
+  "organization": "Ministry of Health and Social Welfare",
+  "authors": [
+    "Dirección General de Vigilancia de la Salud",
+    "Ministerio de Salud Pública y Bienestar Social"
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+          "description": "Arthropod refers to insects or arachnids, such as mosquitoes"
+        },
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+          "name": "Acute fever of unknown origin (FUO)",
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+      "title": "Guía Nacional de Vigilancia y Control de Eventos de Notificación Obligatoria. Sistema Nacional de Vigilancia Epidemiológica. Paraguay, 2022",
+      "url": "https://dgvs.mspbs.gov.py/files/guiaNacional/Guia_de_Vigilancia_2022_act_28_julio.pdf"
+    }
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+    "Human-readable definition was automatically translated from Spanish to English."
+  ],
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+  "human_readable_definition": "Undifferentiated fever due to mosquito bite. Acute febrile syndrome with no apparent cause",
+  "target_public_health_threats": [
+    "arbovirosis"
+  ],
+  "keywords": [
+    "arbovirosis",
+    "Latin America"
+  ],
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+}

machine_readable/json/arbovirosis_paraguay_sd.json

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+    "Ministerio de Salud Pública y Bienestar Social"
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+      "url": "https://dgvs.mspbs.gov.py/files/guiaNacional/Guia_de_Vigilancia_2022_act_28_julio.pdf"
+    },
+    {
+      "url": "https://icd.who.int/browse10/2019/en#/A92.9"
+    }
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+  ],
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+  "target_public_health_threats": [
+    "arbovirosis"
+  ],
+  "keywords": [
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+    "syndrome definition"
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+}

machine_readable/json/avianinfluenzainhumans_australia.json

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+{
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+                },
+                {
+                  "type": "symptom",
+                  "name": "headache"
+                },
+                {
+                  "type": "symptom",
+                  "name": "dyspnoea"
+                },
+                {
+                  "type": "symptom",
+                  "name": "diarrhoea"
+                }
+              ]
+            }
+          ]
+        },
+        {
+          "type": "symptom",
+          "name": "conjunctivitis"
+        },
+        {
+          "type": "criterion",
+          "logical_operator": "AND",
+          "values": [
+            {
+              "type": "symptom",
+              "name": "Infiltrates or evidence of an acute pneumonia on chest radiograph"
+            },
+            {
+              "type": "symptom",
+              "name": "acute respiratory insufficiency",
+              "description": "hypoxaemia, severe tachypnoea"
+            }
+          ]
+        }
+      ]
+    }
+  ],
+  "references": [
+    {
+      "url": "http://www.health.gov.au/casedefinitions"
+    }
+  ],
+  "notes": [],
+  "status": "draft",
+  "human_readable_definition": "Clinical evidence \nAn acute illness characterised by: \n \n1. Fever (>38°C) or history of fever AND one or more of; cough OR rhinorrhoea OR \nmyalgia OR headache OR dyspnoea OR diarrhoea; \nOR \n2. Conjunctivitis \nOR \n3. Infiltrates or evidence of an acute pneumonia on a chest radiograph plus evidence \nof acute respiratory insufficiency (hypoxaemia, severe tachypnoea). \n",
+  "target_public_health_threats": [
+    "Avian Influenza in Humans"
+  ],
+  "keywords": [
+    "Avian Influenza in Humans",
+    "AIH",
+    "Oceania"
+  ],
+  "definition_type": "case_definition"
+}

machine_readable/json/babesiosis_canada.json

@@ -0,0 +1,81 @@
+{
+  "title": "Open Syndrome Babesiosis",
+  "description": "Case definition for suspected babesiosis",
+  "scope": "broad",
+  "category": "suspected",
+  "version": "1.0.0",
+  "open_syndrome_version": "1.0.0",
+  "published_in": "https://opensyndrome.org",
+  "published_at": "2025-01-29T12:00:00Z",
+  "published_by": [
+    "Open Syndrome Initiative"
+  ],
+  "location": "Canada",
+  "language": "English",
+  "organization": "Public Health Agency of Canada",
+  "inclusion_criteria": [
+    {
+      "type": "criterion",
+      "logical_operator": "AND",
+      "values": [
+        {
+          "type": "symptom",
+          "name": "fever"
+        },
+        {
+          "type": "criterion",
+          "logical_operator": "AT_LEAST",
+          "logical_operator_arguments": [
+            1
+          ],
+          "values": [
+            {
+              "type": "symptom",
+              "name": "fatigue"
+            },
+            {
+              "type": "symptom",
+              "name": "chills"
+            },
+            {
+              "type": "symptom",
+              "name": "sweats"
+            },
+            {
+              "type": "symptom",
+              "name": "headache"
+            },
+            {
+              "type": "symptom",
+              "name": "anorexia"
+            },
+            {
+              "type": "symptom",
+              "name": "hemolytic anemia"
+            },
+            {
+              "type": "symptom",
+              "name": "thrombocytopenia"
+            }
+          ]
+        }
+      ]
+    }
+  ],
+  "references": [
+    {
+      "citation": "National Case Definition for Babesiosis, Canada",
+      "url": "https://www.canada.ca/en/public-health/services/diseases/babesiosis/health-professionals/national-case-definition.html"
+    }
+  ],
+  "status": "draft",
+  "human_readable_definition": "Babesiosis infections range in severity from asymptomatic to severe\n(occasionally fatal) depending on host and parasite factors. Most\nsymptomatic infections caused by B. microti  are mild and self-limiting,\ndeveloping 1 to 4 weeks after the tick bite and 1 to 9 weeks after\ncontamination of blood products.  The salient features are fever and\nnon-specific flu-like illness (malaise, fatigue, chills, sweats, and\nheadache).\n",
+  "target_public_health_threats": [
+    "Babesiosis"
+  ],
+  "keywords": [
+    "North America",
+    "Babesiosis"
+  ],
+  "definition_type": "case_definition"
+}

machine_readable/json/cholera_colombia.json

@@ -0,0 +1,52 @@
+{
+  "title": "Open Syndrome Confirmed Case of Cholera",
+  "description": "Laboratory confirmation with positive fecal culture for toxigenic Vibrio cholerae O1 or O139",
+  "scope": "specific",
+  "category": "confirmed",
+  "version": "1.0.0",
+  "open_syndrome_version": "1.0.0",
+  "published_in": "https://opensyndrome.org",
+  "published_at": "2025-02-27T16:16:26Z",
+  "published_by": [
+    "Open Syndrome Initiative"
+  ],
+  "location": "Colombia",
+  "language": "English",
+  "organization": "Instituto Nacional de Salud",
+  "inclusion_criteria": [
+    {
+      "type": "criterion",
+      "name": "Confirmation by Laboratory with Positive Culture of Stool",
+      "logical_operator": "OR",
+      "values": [
+        {
+          "type": "diagnostic_test",
+          "name": "Confirmation by Laboratory with Positive Culture of Stool for Vibrio cholerae O1"
+        },
+        {
+          "type": "diagnostic_test",
+          "name": "Confirmation by Laboratory with Positive Culture of Stool for O139 Toxigenic"
+        }
+      ]
+    }
+  ],
+  "references": [
+    {
+      "citation": "Colombia. Instituto Nacional de Salud. Protocolo de Vigilancia\nen Salud Pública de Cólera. versión 4. [Internet] 2022.\nhttps://doi.org/10.33610/infoeventos.5",
+      "url": "https://www.ins.gov.co/buscador-eventos/Lineamientos/Pro_C%C3%B3lera.pdf"
+    }
+  ],
+  "notes": [
+    "Human-readable definition was automatically translated from Spanish to English."
+  ],
+  "status": "draft",
+  "human_readable_definition": "This is a suspect case that meets any of the following criteria.\n   Confirmation by laboratory with positive stool culture for toxigenic Vibrio cholerae O1 or O139.\n   Confirmation by epidemiological link:\n    • Individual who fits the definition of a suspect case, and has history of contact with a confirmed cholera patient within a period of five days\n    • or a history of active circulation of V. cholerae serotype O1 or O139 toxigenic in the workplace or residence of the case.\n   An area of active circulation is considered one where toxigenic Vibrio cholerae O1 or O139 has been isolated from biological or environmental samples (water, food or food remains).",
+  "target_public_health_threats": [
+    "Cholera"
+  ],
+  "keywords": [
+    "Latin America",
+    "Cholera"
+  ],
+  "definition_type": "case_definition"
+}

machine_readable/json/cholera_ghana.json

@@ -0,0 +1,54 @@
+{
+  "title": "Open Syndrome Cholera",
+  "description": "Case definition for suspected case of cholera",
+  "scope": "broad",
+  "category": "suspected",
+  "version": "1.0.0",
+  "open_syndrome_version": "1.0.0",
+  "published_in": "https://opensyndrome.org",
+  "published_at": "2025-01-29T12:00:00Z",
+  "published_by": [
+    "Open Syndrome Initiative"
+  ],
+  "location": "Ghana",
+  "language": "English",
+  "organization": "Ministry of Health",
+  "inclusion_criteria": [
+    {
+      "type": "criterion",
+      "logical_operator": "AND",
+      "values": [
+        {
+          "type": "demographic_criteria",
+          "name": "5 years old or more",
+          "attribute": "age",
+          "operator": ">=",
+          "value": 5,
+          "unit": "years"
+        },
+        {
+          "type": "symptom",
+          "name": "Acute watery diarrhea"
+        }
+      ]
+    }
+  ],
+  "notes": [
+    "If there is a cholera epidemic, a suspected case is a person age 5 years or more with acute watery diarrhoea, with or without vomiting."
+  ],
+  "references": [
+    {
+      "url": "https://www.moh.gov.gh/wp-content/uploads/2016/02/Integrated-Disease-Surveillance-and-Response-Ghana-Guidelines.pdf"
+    }
+  ],
+  "status": "draft",
+  "human_readable_definition": "In a patient age 5 years or more, severe dehydration or death from acute watery diarrhoea\n(rice water stool).\nIf there is a cholera epidemic, a suspected case is a person age 5 years or more with acute\nwatery diarrhoea, with or without vomiting.",
+  "target_public_health_threats": [
+    "Cholera"
+  ],
+  "keywords": [
+    "Cholera",
+    "Africa"
+  ],
+  "definition_type": "case_definition"
+}

machine_readable/json/covid19_egypt.json

@@ -0,0 +1,90 @@
+{
+  "title": "Open Syndrome COVID-19 (Egypt)",
+  "description": "",
+  "scope": "broad",
+  "category": "suspected",
+  "version": "1.0.0",
+  "open_syndrome_version": "1.0.0",
+  "published_in": "https://opensyndrome.org",
+  "published_at": "2020-05-30T12:00:00Z",
+  "published_by": [
+    "Open Syndrome Initiative"
+  ],
+  "location": "Egypt",
+  "language": "English",
+  "organization": "Ministry of health and population (MOHP)",
+  "inclusion_criteria": [
+    {
+      "type": "criterion",
+      "logical_operator": "OR",
+      "values": [
+        {
+          "type": "criterion",
+          "name": "A. Any one of the epidemiological history with any of the clinical features",
+          "logical_operator": "OR",
+          "values": [
+            {
+              "type": "epidemiological_history",
+              "name": "History of travel to or residence in communities where cases reported within the last 14 days"
+            },
+            {
+              "type": "epidemiological_history",
+              "name": "In contact with a patient who has fever or respiratory symptoms or from a community with confirmed cases reported within the last 14 days"
+            }
+          ]
+        },
+        {
+          "type": "criterion",
+          "name": "B. Assessing the presence of at least two of the following clinical features",
+          "logical_operator": "AT_LEAST",
+          "logical_operator_arguments": [
+            2
+          ],
+          "values": [
+            {
+              "type": "symptom",
+              "name": "Fever and/or respiratory symptoms"
+            },
+            {
+              "type": "professional_judgment",
+              "name": "Imaging characteristics"
+            },
+            {
+              "type": "professional_judgment",
+              "name": "Differential CBC findings",
+              "description": "White blood cells is normal or decreased, with decreased lymphocytic count."
+            }
+          ]
+        },
+        {
+          "type": "criterion",
+          "name": "C. Severe Acute Respiratory Infection (SARI) with no other obvious cause",
+          "logical_operator": "OR",
+          "values": [
+            {
+              "type": "professional_judgment",
+              "name": "Severe Acute Respiratory Infection (SARI) with other obvious cause for SARI"
+            }
+          ]
+        }
+      ]
+    }
+  ],
+  "references": [
+    {
+      "citation": "Masoud, Hossam & Elassal, Gehan & Zaky, Samy & Baki, Amin & Ibrahem, Hamdy & Amin, Wagdy & Abdelbary, Akram & Abdalmohsen, Ahmad & Hassany, Mohamed & Eid, Alaa & Asem, Noha & Kamal, Ehab. (2020). Management Protocol for COVID-19 Patients Version 1.4/30th May 2020 Ministry of health and population (MOHP), Egypt.",
+      "url": "https://www.researchgate.net/publication/344078546_Management_Protocol_for_COVID-19_Patients_Version_1430th_May_2020_Ministry_of_health_and_population_MOHP_Egypt"
+    }
+  ],
+  "notes": [],
+  "status": "draft",
+  "human_readable_definition": "A\nAny one of the epidemiological \nhistory with any of the clinical \nfeatures.\nepidemiological history:\n1. History of travel to or \nresidence in communities \nwhere cases reported within \nthe last 14 days.\n2. In contact with viral RNA \npositive people\nwithin the last 14 days.\n3. In contact with a patient who \nhas fever or respiratory \nsymptoms or from a \ncommunity\nwith confirmed cases reported \nwithin the last 14 days.\nB\nAsessing the presence of at \nleast two of the following \nclinical features:\n1.Fever and/or respiratory \nsymptoms.\n2.Imaging characteristics. \nCT scan is preferred, if not \nappicable do CXR\n3.Differential CBC findings:\nwhite blood cells is normal \nor decreased, with decreased \nlymphocytic count.\nC\nSevere Acute Respiratory \nInfection\n(SARI) with no other \nobvious cause.\n",
+  "target_public_health_threats": [
+    "COVID-19"
+  ],
+  "keywords": [
+    "COVID-19",
+    "Africa"
+  ],
+  "definition_type": "case_definition"
+}

machine_readable/json/covid19_philippines.json

@@ -0,0 +1,102 @@
+{
+  "title": "Open Syndrome COVID-19 (Philippines)",
+  "description": "COVID-19 suspected case definition for the Philippines",
+  "scope": "broad",
+  "category": "suspected",
+  "version": "1.0.0",
+  "open_syndrome_version": "1.0.0",
+  "published_in": "https://opensyndrome.org",
+  "published_at": "2025-01-29T12:00:00Z",
+  "published_by": [
+    "Open Syndrome Initiative"
+  ],
+  "location": "Philippines",
+  "language": "English",
+  "organization": "Department of Health",
+  "inclusion_criteria": [
+    {
+      "type": "criterion",
+      "logical_operator": "OR",
+      "values": [
+        {
+          "type": "criterion",
+          "logical_operator": "AND",
+          "values": [
+            {
+              "type": "symptom",
+              "name": "fever"
+            },
+            {
+              "type": "symptom",
+              "name": "cough"
+            }
+          ]
+        },
+        {
+          "type": "criterion",
+          "logical_operator": "AT_LEAST",
+          "logical_operator_arguments": [
+            3
+          ],
+          "values": [
+            {
+              "type": "symptom",
+              "name": "fever"
+            },
+            {
+              "type": "symptom",
+              "name": "cough"
+            },
+            {
+              "type": "symptom",
+              "name": "general weakness"
+            },
+            {
+              "type": "symptom",
+              "name": "fatigue"
+            },
+            {
+              "type": "symptom",
+              "name": "headache"
+            },
+            {
+              "type": "symptom",
+              "name": "myalgia"
+            },
+            {
+              "type": "symptom",
+              "name": "sore throat"
+            },
+            {
+              "type": "symptom",
+              "name": "coryza"
+            },
+            {
+              "type": "symptom",
+              "name": "dyspnea"
+            },
+            {
+              "type": "symptom",
+              "name": "anorexia/nausea/vomiting/diarrhea"
+            },
+            {
+              "type": "professional_judgment",
+              "name": "altered mental status"
+            }
+          ]
+        }
+      ]
+    }
+  ],
+  "references": [],
+  "status": "draft",
+  "human_readable_definition": "A. Suspect Case \n1. A person who meets the clinical AND epidemiologic criteria: \na. Clinical criteria \ni. Acute onset of fever AND cough OR \nii. Acute onset of any of the three or more of the following signs or symptoms: \nfever, cough, general weakness, fatigue, headache, myalgia, sor e throat, \ncoryza, dyspnea, anorexia/nausea/vomiting/diarrhea, altered men tal \nstatus \nb. Epidemiologic criteria \ni. Residing or working in an area with high risk of transmissio n of the virus: \nfor example, closed residential settings and humanitarian settings such as \ncamp and camp-like settings for displaced persons, any time within the 14 \ndays prior to symptoms onset; OR \nii. Residing in or travel to an area with community transmission anytime within \nthe 14 days prior to symptom onset OR \niii. Working in health settings including within health facilit ies and within \nhouseholds, anytime within the 14 days prior to symptoms onset \nc. Patient with severe acute respiratory illness (SARI: acute r espiratory infection \nwith history of fever or measured fever > 38 C, and cough with onset within the \nlast 10 days and who require hospitalization) \n",
+  "target_public_health_threats": [
+    "COVID-19"
+  ],
+  "keywords": [
+    "COVID-19",
+    "Asia"
+  ],
+  "definition_type": "case_definition"
+}

machine_readable/json/dengue_usa.json

@@ -0,0 +1,124 @@
+{
+  "title": "Open Syndrome Dengue",
+  "description": "Case definition for dengue surveillance based on chief complaints and multiple diagnostic coding systems",
+  "scope": "broad",
+  "category": "suspected",
+  "version": "1.0.0",
+  "open_syndrome_version": "1.0.0",
+  "published_in": "https://opensyndrome.org",
+  "published_at": "2025-01-29T12:00:00Z",
+  "published_by": [
+    "Open Syndrome Initiative"
+  ],
+  "location": "United States",
+  "language": "English",
+  "organization": "CDC",
+  "inclusion_criteria": [
+    {
+      "type": "criterion",
+      "logical_operator": "OR",
+      "values": [
+        {
+          "type": "diagnosis",
+          "name": "Dengue in chief complaint",
+          "description": "Dengue word in chief complaint field",
+          "operator": "regex",
+          "regex_pattern": "dengue",
+          "regex_flags": "i"
+        },
+        {
+          "type": "diagnosis",
+          "name": "Dengue fever",
+          "description": "Dengue fever (A90) or Dengue hemorrhagic fever (A91)",
+          "code": {
+            "system": "ICD-10",
+            "code": "A90"
+          }
+        },
+        {
+          "type": "diagnosis",
+          "name": "Dengue hemorrhagic fever",
+          "code": {
+            "system": "ICD-10",
+            "code": "A91"
+          }
+        },
+        {
+          "type": "diagnosis",
+          "name": "Dengue",
+          "code": {
+            "system": "ICD-9",
+            "code": "061",
+            "display": "Dengue"
+          }
+        },
+        {
+          "type": "diagnosis",
+          "name": "Dengue",
+          "code": {
+            "system": "SNOMED-CT",
+            "code": "38362002",
+            "display": "Dengue"
+          }
+        },
+        {
+          "type": "diagnosis",
+          "name": "Severe Dengue",
+          "code": {
+            "system": "SNOMED-CT",
+            "code": "20927009",
+            "display": "Severe Dengue"
+          }
+        },
+        {
+          "type": "diagnosis",
+          "name": "Dengue shock syndrome",
+          "code": {
+            "system": "SNOMED-CT",
+            "code": "409671005",
+            "display": "Dengue shock syndrome"
+          }
+        },
+        {
+          "type": "diagnosis",
+          "name": "Myelitis caused by Dengue virus",
+          "code": {
+            "system": "SNOMED-CT",
+            "code": "866057003",
+            "display": "Myelitis caused by Dengue virus"
+          }
+        },
+        {
+          "type": "diagnosis",
+          "name": "Encephalitis caused by Dengue virus",
+          "code": {
+            "system": "SNOMED-CT",
+            "code": "1163101003",
+            "display": "Encephalitis caused by Dengue virus"
+          }
+        }
+      ]
+    }
+  ],
+  "references": [
+    {
+      "citation": "Dengue Case Definition v1",
+      "url": "https://knowledgerepository.syndromicsurveillance.org/dengue-v1"
+    }
+  ],
+  "notes": [
+    "Case definition based on Chief Complaint Discharge Diagnosis (CCDD) parsed field",
+    "No exclusion terms or codes are used in this query"
+  ],
+  "status": "draft",
+  "human_readable_definition": "",
+  "target_public_health_threats": [
+    "Dengue"
+  ],
+  "keywords": [
+    "Dengue",
+    "North America",
+    "Arbovirus"
+  ],
+  "definition_type": "case_definition"
+}

machine_readable/json/denguefever_malaysia.json

@@ -0,0 +1,83 @@
+{
+  "title": "Open Syndrome Dengue Fever",
+  "description": "",
+  "scope": "broad",
+  "category": "suspected",
+  "version": "1.0.0",
+  "open_syndrome_version": "1.0.0",
+  "published_in": "https://opensyndrome.org",
+  "published_at": "2025-01-29T12:00:00Z",
+  "published_by": [
+    "Open Syndrome Initiative"
+  ],
+  "location": "Malaysia",
+  "language": "English",
+  "organization": "Ministry of Health",
+  "authors": [
+    "Vector Borne Disease Sector - Disease Control Division"
+  ],
+  "inclusion_criteria": [
+    {
+      "type": "criterion",
+      "logical_operator": "AND",
+      "values": [
+        {
+          "type": "symptom",
+          "name": "Acute onset of high grade fever of usually 2-5 days or more"
+        },
+        {
+          "type": "criterion",
+          "name": "Other symptoms",
+          "logical_operator": "AT_LEAST",
+          "logical_operator_arguments": [
+            2
+          ],
+          "values": [
+            {
+              "type": "symptom",
+              "name": "headache"
+            },
+            {
+              "type": "symptom",
+              "name": "retro-orbital pain"
+            },
+            {
+              "type": "symptom",
+              "name": "myalgia"
+            },
+            {
+              "type": "symptom",
+              "name": "arthralgia"
+            },
+            {
+              "type": "symptom",
+              "name": "rash"
+            },
+            {
+              "type": "symptom",
+              "name": "mild haemorrhagic manifestation",
+              "description": "e.g. epistaxis, gums bleeding and petechiae"
+            }
+          ]
+        }
+      ]
+    }
+  ],
+  "references": [
+    {
+      "citation": "Case Definition of Infectious Disease 3rd Edition 2017",
+      "url": "https://www2.moh.gov.my/moh/resources/Penerbitan/Garis%20Panduan/Pengurusan%20KEsihatan%20&%20kawalan%20pykit/Case_Definition_Of_Infectious_Disease_3rd_Edition_2017.pdf"
+    }
+  ],
+  "status": "draft",
+  "human_readable_definition": "Acute onset of high grade fever of usually 2-5 days or more associated with two or more\nof the following: headache, retro-orbital pain, myalgia, arthralgia, rash and mild\nhaemorrhagic manifestation (epistaxis, gums bleeding and petechiae).",
+  "target_public_health_threats": [
+    "Dengue fever"
+  ],
+  "keywords": [
+    "Dengue",
+    "Arbovirosis",
+    "Asia"
+  ],
+  "definition_type": "case_definition"
+}