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A signaling molecule is the way by which cells communicate with each other. Three general types of intercellular communication are mediated by messengers in the ECF: neural -in which neurotransmitters are released at synaptic junctions endocrine - in which hormones and growth factors reach cells the circulating blood o...
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Neural crest Derivatives of Neural crest cellsSpinal gangliaGanglia of autonomic nervous systemGanglia of cranial nerves (V, VII, VIII, IX, X)Sheaths of peripheral nervesMeningeal coverings of brain & spinal cordPigment cells (melanocytes)Adrenal medullaOdontoblasts of toothChromaffin tissueCells arising from the crani...
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Health assistant (male) covers: 30,000 population in plains. 20,000 population in hilly/tribal areas. Also remember, population covered by: 1 Sub-center in plains- 5,000; Hilly/tribal areas- 3,000. 1 CHC in plains- 1,20,000 ; Hilly/tribal areas - 80,000.
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Vasopressin is a hormone secreted by cells of the hypothalamic nuclei and stored in the posterior pituitary for release as necessary; its stimulates contraction of the muscular tissues of the capillaries and aerioles, raising the blood pressure, and increases peristalsis, exe some influence on the uterus, and resorptio...
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Mycotic
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D i.e. Othello Syndrome This person is having disorder as he is having persistent delusion of infidelity without other personality disturbance, and hallucination (so schizophrenia is ruled out). Delusional disorders are differentiated from Schizophrenia by presence of systemetic delusions (Bizarre in Schizophrenia) wit...
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Ans. is 'a' i.e., CRAO Central Retinal Artery Occlusion (CRAP)o The circulation to the retina enters the eye through the central retinal artery. Therefore, its blockade causes severe ischemia to retina. Patient notices sudden painless loss of vision, within a few minutes the eye may become totally blind. Patients's wit...
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- Excess GH results in: overgrowth / gigantism during childhood with open epiphysis * After fusion of epiphysis - ACROMEGALY - Features of Acromegaly: Coarse facies large tongue Prognathism(protruded lower jaw) thick skin broad nose headache & visual field defects - Best screening test - IGF 1 levels - TREATMENT: Somat...
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Metropathia hemorrhagica Prolonged amenorrhea followed by heavy withdrawl Amenorrhea for 2 1/2 -3 months In a women >40 yrs Anovulatory cycle, irregular Hyperplasia of endometrial glands present Non secretory endometrium Diagnosed by currettage and microscopic examination Cystic glandular hyperplasia (Swiss cheese endo...
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Pupil-sparing oculomotor nerve palsy is often assumed to be caused by ischemic injury such as hypeension and diabetes mellitus. Sometimes compressive lesion can cause pupil-sparing oculomotor nerve palsy with a sho interval from the onset of symptoms to diagnosis.
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Ans. is 'a' i.e., 2 million In humans, no new ova are formed after bih. During fetal development, the ovaries contain over 7 million primordial follicles. However,-many undergo atresia (involution) before bih and others are lost after bih. At the time of bih, there are 2 million ova, but 50% of these are atretic. The m...
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Lithium- * Lithium is a commonly prescribed medication for aggressive behaviors in a wide array of patients, including those with bipolar disorder, schizophrenia, conduct disorder, and intellectual disability. Its effect in increasing brain 5-HT function may be relevant in anti-suicidal propey. The required plasma conc...
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Level of intelligence IQ range Idiot 0-24 Imbecile 25-49 Moron 50-69 Borderline 70-79 Low normal 80-89 Normal 90-109 Superior 110-119 Very superior 120-139 Near genius 140 and above Ref: Park's textbook of Preventive and Social Medicine, 21st edition, page-629
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The toxins of Staphylococcus are: Cytolytic toxins: which include alpha-hemolysin, beta-hemolysin, gamma hemolysin, delta hemolysin and leucocidin Leucocidin (called the Panton-Valentine toxin or PVL after its discoverers) is a two-component toxin like gamma lysin, being composed of S and F components. Such bi-componen...
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Answer is A (Classical PAN): Classical PAN is a predominantly medium vessel vasculitis and not a small vessel vasculitis.
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Ans. c (Ketamine). (Ref. KD Tripathi Pharmacology 6th/pg. 376).With KETAMINE, Emergence delirium, hallucinations and involuntary movements occur upto 50% patients during recovery; but injection is not painful.Ketamine# Ketamine is pharmacologically related to the hallucinogen phencyclidine; induces so called 'dissociat...
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Positional veigo is commonly due to pathology in the Posterior Semicircular Canal.BPPV is the commonest cause of peripheral veigoRef: Hazarika; 3rd ed; Pg 105
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Ans. Spectacles
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Acute tubular necrosis (ATN) may produce oliguria, decreased glomerular filtration rate (GFR), increased fractional excretion of sodium, and an abnormal urinary sediment. ATN may be caused by renal ischemia (ischemic ATN) or chemical toxins (toxic ATN). Renal ischemia is the most common cause of ATN, while toxic ATN ma...
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Ans. is c i.e. Has history of ectopic pregnancy The planned parenthood federation of America has described Ideal IUCD candidate as a woman. Who has no history of pelvic disease. Who has born at least one child Has normal menstrual periods Is willing to check IUCD tail Has access to follow up and t/t of potential proble...
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Hypogammaglobulinemia is seen in thymoma not Hypergammaglobulinemia . ref harrisons internal medicine 20e p2496 , 729 ,3232, 3237
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Clinical manifestations of adrenocoical insufficiency include hyperkalemia, hyponatremia, hypoglycemia, fever, weight loss, and dehydration. There is excessive sodium loss in the urine, contraction of the plasma volume, and perhaps hypotension or shock. Classic hyperpigmentation is present in chronic Addison disease on...
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Retinoblastoma: It is the most common primary intraocular malignancy of childhood. The mutation occurs in the retinoblastoma gene (Rb) at chromosome 13q14. This is a tumor suppressor gene. One mutated copy may be inherited in an autosomal dominant fashion (germline mutation). If a second mutation spontaneously occurs i...
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Ans. is 'b' i.e., Lecithinase(Ref: Ananthanarayan, 9th/e, p. 251-255 and 8th/e, p. 252-253)Naegler's reaction: This reaction is produced by C. perfringens as opalescence in 20% human serum or egg yolk media due to Lecithinase (phospholipase) activity of alpha toxin, it splits lecithin into phosphorylcholine and diacylg...
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YIELD Yield of the screening test: is the amount of previously unrecognized disease that is diagnosed as result of screening effo Yield of the screening test depends on: -Sensitivity of screening test -Specificity of screening test -Prevalence of the disease in population -Paicipation of individuals in the detection pr...
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Ans. is 'a' i.e., CMV
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Ans. is 'd' i.e., All of the above There is no reliable test available to determine the efficacy of a disinfectant. This is due to the number of parameters which influence disinfectant activity. Traditionally in such tests phenol is taken as the standard. Two impoant tests are :- i) Rideal-Walker test Suspensions conta...
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Methods in which vectors transmit agents: Biting Regurgitation Scratching in of infective faeces Contamination of host with body fluids of vectors (refer pgno:98 park 23 rd edition)
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B. i.e. (Inferior vena-cava) (317- BDC-2 4th) (245- Snell 8th)The portal vein enters the liver and breaks up into sinusoids, from which blood passes into the hepatic veins that join the inferior vena cava.Tributaries of the Portal veinTributaries of Inferior vena-cava* Splenic vein* Inferior mesenteric vein* Superior m...
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Prinzmetal's angina is due to spasm of main coronary aery. Treatment is by dilatation of coronary aery. Endothelium normally generates NO, but here we are giving nitrates for generation of NO. Mechanism of action of nitrates: Preload reduction >> Afterload reduction Redistribution of coronary flow in the aerial tree ac...
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The characteristics of occupational cancer are : They appear after prolonged exposure (the period being as long as 10-25 years) The disease may appear even after cessation of exposure. The disease may develop even after cessation of exposure The average age incidence is earlier than that of cancer in general. The loca...
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The radio-immune assay stands out to be the most sensitive test to measure the beta sub-unit of human chorionic gonadotropin in which a quantitative assessment of levels more than 5mIU/ml is read as positive. Thus even very minute quantities of the hormone can be detected as following the implantation of the blastocyst...
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Ans. is 'a' i.e., Haemophilus o The growth of Haemophilus influenzae is scanty on blood agar, as the factor V is not freely available, being imprisoned inside the red blood cells.o Growth is, therefore, better if the source of the V factor is also provided. When Staph aureus is streaked across a plate of blood agar on ...
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(A) DIC# Disseminated Intravascular Coagulation (DIC), also known as disseminated intravascular coagulopathy or less commonly as consumptive coagulopathy, is a pathological process characterized by the widespread activation of the clotting cascade that results in the formation of blood clots in the small blood vessels ...
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(Ref: Katzung 14th ed. P 661)DOC for chronic gout/period between acute gout attacks: AllopurinolMOA: Xanthine oxidase inhibitorWhen initiating allopurinol therapy, colchicine or NSAID should be used until steady-state serum uric acid is normalized or decreased to less than 6mg/dL and they should be continued for 6 mont...
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Ans. is 'c' i.e., Intravenous pantoprozole Maingot states "Because all sources of upper G.I. bleeding involves a disruption of mucosa, pharmacological inhibition of gastric acid secretion is provided empirically? So if the diagnosis of the patient with acute upper gastrointestinal bleeding cannot be confirmed endoscopi...
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Ans. b. Inveed saucer shaped lesions Often a single lesion is present surrounded by several smaller ones. Skin and nerves are the only directly affected tissues in BL (Borderline Lepromatous). The skin lesions consist of erythematous macules or plaques. Inveed saucer-shaped annular lesions are characteristic
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Ans. D. Cholera gravisExplanationVibrio choleraThey are curve (comma-shaped) gram negative, bacilli that are actively motile (single polar flagellum).Classification:Based on salt requirementHalophilic vibrios: They can't grow in the absence of salt. They can tolerate salt at 7-10%. examples are V. parahaemolyticus, V. ...
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Ans. is 'b' i.e., It occurs commonly in children above 2 years of age
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Rocky mountain spotted fever is caused by R.ricketsii.vector is dermacentar andersonii it is prevalent in noh america and South America. It is the most serious type of spotted fever Ref: AnanthNarayan and paniker's 10th edition
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The weight loss and pain suggest a malignant neoplasm. Jaundice (a conjugated hyperbilirubinemia) occurs because of biliary tract obstruction by a mass in the head of the pancreas. Such a carcinoma may manifest with "painless jaundice" as well, but it is more likely to invade the nerves around the pancreas, causing pai...
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Ans. is 'a' i.e., Capsicum
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Ans. B: Hyperglycemia Inhibitors of GH secretion include Somatostatin from the periventricular nucleus Circulating concentrations of GH and IGF-1 (negative feedback on the pituitary and hypothalamus Hyperglycemia Glucocoicoids Dihydrotestosterone Stimulators of GH secretion include Peptide hormones - Growth hormone rel...
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Daisy head - Gravis Frog's egg colony - Intermedius Poached egg - Mitis.
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Barr body (Sex - chromatin) It is a densely staining inactivated condensed 'X' chromosome that is present in each somatic cells of the female. It is found in the nucleus. It is used as a test of genetic femaleness → it is possible to determine the genetic sex of an individual according as to whether there is a chromat...
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Distension of the colon and gastro - colic reflex stimulates mass movement through the myenteric plexus / Auerbach plexus. So if it destroyed, mass movement gets abolished.
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Ans. Increased mitotic figures in centre of cornea
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Ans. is 'b' i.e., Neurofibromatosis 1 * Lisch nodules are the most common type of ocular involvement in NF-1. These nodules are melanocytic hamartomas, usually clear yellow to brown, that appear as well-defined, dome-shaped elevations projecting from the surface of the iris.
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The clinical scenario shows a child who had normal development previously and then presenting with symptoms of lactic acidosis and stroke(seizures with focal neurological deficits). The microscopy of muscle biopsy with modified Gomori trichrome staining shows ragged red fibers (arrowhead). Based on these features, the ...
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The population that subsist on the millet Panicum miliare, may get contaminated with weed seeds of Crotalaria (Jhunjhunia).Jhunjhunia seeds were found to contain pyrrolizidine alkaloids which are hepatotoxins, cause Endemic ascitesPark23e pg: 658
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Ans is 'c' i.e. Anterior urethritis The "three glass test" is useful is differentiating the site of hematuria or pyuria. The patient is asked to void and collect separately the first 10 ml, the midstream and the last few drops in 3 separate labeled containers. Largest number of cells (blood or pus) in: - the first cont...
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Image shows ventricular rate of 30/min with no relation between P waves and qRS complexes. QRS complexes are broad indicating origin from the ventricle and presence of escape rhythm. All these findings indicate presence of complete hea block. She needs a permanent pacemaker. However in the current circumstances she nee...
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Controlled mechanical ventilation is total support ventilator, i.e. total support is provided by ventilator :- ventilator is active and does all the work; patient is passive. CMV is also known as intermittent positive pressure ventilation (IPPV).
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Systemic vitamin E and glucocoicoids inhibit the inflammatory response and collagen synthesis, thereby possibly impeding the healing process. REF: Harrison book of internal medicine 21ST EDITION
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When the cell membrane-bound enzyme NADPH oxidase is activated, with the production of toxic oxygen metabolites. The combination of the toxic oxygen metabolites and the proteolytic enzymes from the granules makes the neutrophil a very effective killing machine. Activation of NADPH oxidase is associated with a sharp inc...
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Onset of fatigue, ahralgias, mucosal ulcerations, and facial rash in a young person strongly suggests SLE. Additional features of SLE are low-grade fever, alopecia, pericarditis, ahritis, nephritis, nervous system involvement, and pleural effusions. Women are affected ten times more often than men. The lupus band test,...
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D i.e. Calcified lesions
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Nonoxynol
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Coliforms are E. coli (faecal) and Klebsiella (non-faecal). E. coli is the most typical faecal coliform. They are chosen as the indicators of faecal pollution of water because, They are constantly present in abundance in the human intestine. They can be easily detected by culture methods. they tend to survive longer th...
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Ans. is 'a' i.e., Growns in 6.5% Nacl solution
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Ans. is 'b' i.e., Left umbilical vein o The ligament teres represents the obliterated left umbilical vein.o Repeat from previous sessions.
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Ans. Hyperparathyroidism
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The occipitofrontalis muscle has two bellies, occipital or occipitalis and frontal or frontalis, both of  which are inserted into the epicranial aponeurosis. The occipital bellies are small and separate.  Each  arises from the lateral two-thirds of the superior nuchal line. The frontal bellies are longer, wider and par...
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Ans. is 'd' i.e., Tetralogy of fallot o Features in this child suggestive of TOF : - i) Cyanosis at 2 year (not at bih) ii) No pallor, dysnea or edema No CHF iii) Normal sized hea o These features suggest the diagnosis of TOF. o These have been explained earlier.
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At 2 - 3 days the scab is reddish-brown.
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<p>Primary hyperparathyroidism is a generalized disorder of calcium, phosphate, and bone metabolism due to an increased secretion of PTH. The elevation of circulating hormone usually leads to hypercalcemia and hypophosphatemia. There is great variation in the manifestations. Patients may present with multiple signs and...
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CD-95 is a marker of death receptor. It is involved in extrinsic pathway of apoptosis.
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Ref: 25th Ed K.Park's Textbook Of Preventive and Social Medicine
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Ans. (d) All of the aboveRef : Shaws 15th ed. /110-111, Harrison 19/e 635; D.C Dutta 6th Ed. 1422-423In turner syndrome* Deletion of genetic material from an X chromosome accounts for about two thirds of gonadal dysgenesis which leads to a condition called turner syndrome (XO).* A 45, X karyotype is found in about half...
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The Anitschkow cell or caterpillar cell is a modified histiocyte which is called so because of its ribbon like wavy chromatin when seen on longitudinal section. On transverse section, “owl’s eye” nuclei are seen. They, along with plasma cells and lymphocytes, constitute an Aschoff nodule seen classically in the myocard...
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(Hyperendemic): (90- Park 22nd/edition)Hyperendemic - expresses that the disease is constantly present at a high incidence and /or prevalence rate and affects all age groups equallyHoloendemic - a high level of infection beginning early in life and affecting most of the child populationPandemic - usually affecting a la...
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Prolonged jaundice, constipation, Umbilical hernia are all seen in congenital hypothyroidism.
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(Ref: K DT 6/e p354) Adrenaline and felypressin are the vasoconstrictors that are added to LA solution. By causing vasoconstriction, these drugs - decrease the systemic absorption resulting in less CNS adverse effects (decreased chances of seizures). Prolong the stay of drug at the site of action resulting in the incre...
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Gastric Stricture: A condition in which there is a central constriction of the wall of the stomach dividing it into two cavities, cardiac and pyloric.
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Ans. is 'd' i.e., Propionobacterium
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Sclerosing agents mentioned in the latest editions of Schwartz, CSDT and Bailey are: - hypertonic saline, - sodium tetradecyl sulfate, and - polidocanol 2 other sclerosants are mentioned in KDT 6/e p597 Ethanolamine oleate Phenol in almond oil or Peanut oil
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The most common organisms implicated in acute cholangitis are Escherichia coli (27%), Klebsiella species (16%), Enterobacter, Streptococcus viridans (8%), Enterococcus and anaerobes. Ref: CURRENT Diagnosis and Treatment: Gastroenterology, Hepatology and Endoscopy, 2nd Edition, Chapter 32.
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Ans. is 'c' i.e., Brachiocephalic trunk o Branches of arch of aorta areBrachiocephalic trunkLeft common carotid arteryLeft subclavian arteryo Right common carotid artery and right subclavian artery arise from brachiocephalic trunk (Brachiocephalic trunk divides into right common carotid and right subclavian arteries).
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Ref: Harrison 20th, P 2084As an aneurysm develops, it typically forms a neck with a dome. The length of the neck and the size of the dome vary greatly and are important factors in planning neurosurgical obliteration or endovascular embolization. The arterial internal elastic lamina disappears at the base of the neck. T...
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Ectopic pregnancy is characterised by the triad of amenorrhoea, pain and BPV of which the most common symptom is pain. The diagnosis is based on clinical features and ultrasound, though laparoscopy is the gold standard. When diagnosis is in doubt serial estimation of HCG is done over 48 hrs. A rise < 66% is s/o ectropi...
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Detection of NTD most specific test: ACE (acetylcholinesterase) most sensitive test: AFP (alfa feto protein) Neural tube defects can be distinguished from other fetal defects (e.g. abdominal wall defects) by use of the acetylcholinesterase test performed on amniotic fluid obtained by amniocentesis Acetylcholinesterase ...
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Ans. is 'a' i.e., Respiratory stimulant Doxapram o A respiratory stimulant (analeptic). o It acts by promoting excitation of central neurons. o At low doses it is more selective for respiratory centre than other analeptics. o Respiration is also stimulated by aoic and carotid body chemoreceptors. Also know o Modafinil ...
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Ans. (a) Myocardial infarction.* This tracing reveals sinus tachycardia at a rate of 100 beats/ min. The axis is normal.* Complete right bundle branch block is present, with a qR complex in VI and broad terminal S wave in V6 and lead I. There are pathologic Q waves in the septal leads of V1 and V2 with ST-segment eleva...
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Ans: B (Osteoarthritis) Ref: Campbell's Operative Orthopaedics, 11th editionExpfanation:Knee OsteoarthritisSymptomso Paino Swelling (due to Joint effusion)o Stiffnesso Crepitus with range of motiono Large osteophytes as palpable swellings (in later stages).Osteoarthritis of the knee first start in the pateliofemoral jo...
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Ans. is b i.e. Wolf Parkinson white syndrome
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Ans. is 'a' i.e., Fe The demand of iron during pregnancy is markedly increased. This is mostly limited to the second half of pregnancy specially to the last 12 weeks. An adequate balanced diet provides about 18 - 20 mg of iron. The amount of iron absorbed from the diet and that mobilized from the store arc inadequate t...
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Glutathione reductase contains a flavoprotein containing FAD. Reduced glutathione removes H2O2 in a reaction catalyzed by glutathione peroxidase, an enzyme that contains the selenium analogue of cysteine (selenocysteine) at the active site. Ref: Harper 28th edition, chapter 21.
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Ascariasis
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Ans. Breakdown of inner blood retinal barrier
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The above presentation is characteristic of freshwater drowning.
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c. Hypoalbuminemia(Ref: Nelson 20/e p 2521 and Harrison 19th ed/pg 253)Edema is the most common presenting symptom of children with nephrotic syndrome. Causes of Edema:In Nephrotic Syndrome: (primarily hypoalbuminemia)Primary alteration in the nephrotic syndrome is a diminished colloid oncotic pressure due to losses of...
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Ans. (b) Cholesterol Cholesterol: Pale yellow - Only Cholesterol is present 15% are Radio opaque* Black: Hard Stone- Insoluble Bilirubin Pigment polymer+ Calcium Phosphate + Calcium Carbonate Brown: Soft friable like Earth sand- Calcium Bilirubinate+ Calcium Palmitate+ Calcium Stearate+CholesterolBlack stones are 60% r...
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HIV related ahritis: 1. Presents as an asymmetric oligo ahritis (MC), symmetrical polyahritis or as a monoahritis. 2. Males > Females 3. Most common joint effected: knee 4. Patients lack features of mucocutaneous involvement or enthesopathy 5. Symmetrical polyahritis (non-erosive) variant closely mimics RA. 6. Occasion...
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Suicide is common in :- Endogenous depression, psychotic depression, involutional (old age) depression.
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TUMOR cells with very high rate ||| of growth - during Chemo Therapy - large no of cells are dyinge TUMOR cell lysis syndrome. i.e. Summary- components of Tumor-Lysis Syndrome HYPERKALEMIA HYPERURICEMIA HYPERPHOSPHATEMIA HYPOCALCEMIA
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SUPERIOR GLUTEAL NERVE Root value: L4,L5,S1Course: enters the gluteal region through greater sciatic notch above pyriformis muscle. Runs between gluteus medius and gluteus minimus to end in tensor fascia lata. Branches :-it supplies 1. Gluteus medius 2. Gluteus minimus3. Tensor fascia lata {Reference: BDC 6E pg no. 173...
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Answer is A (Etidronate): Etidronate is a first generation bisphosphonate, used for the management of Hypercalcemia (not used fir Hypocalcemia). `Treatment of Hypocalcemia includes Calcium replacement with Vitamin D analogs along with Thiazide diuretics to prevent excess calcium excretion besides replenishing any decre...
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Thromboxane A2, Leukotrienes C4, D4, E4 are vasoconstrictors. PGI2, PGE1, PGE2, PGD2 and lipoxins are vasodilators.Ref: Robbins Basic Pathology, 7th Edition, Page 48.
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Toxoplasma gondii * Worldwide * Zoonotic parasite; Toxoplasma is an oppounistic pathogen. * Infects animals, cattle, birds, rodents, pigs, and sheep. * and humans. * Causes the disease Toxoplasmosis. * Toxoplasmosis is leading cause of aboion in sheep and goats. * Intracellular parasite. * Final host (Felidae family, c...
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Ans. is 'a' i.e. Nymphomania Sexual dysfunction* Sexual dysfunction are characterized by repeated inability to participate in sexual relationship or its unsatisfying nature. Important sexual dysfunctions are: -1. Disorder of sexual desire:- i) Excessive sexual desire - Satyriasis in males and nymphomania in women, ii) ...
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