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The most common presenting symptoms relate to weakness of eye muscles, causing ptosis or diplopia. Difficulty in chewing, dysarthria, and dysphagia are also common. The differential diagnosis includes all diseases that cause weakness of oropharyngeal or limb muscles. These include the muscular dystrophies, ALS, and pro...
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Golgi apparatus
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Ans. is 'a' i.e., May contain both DNA and RNA Propeies of viruses . Viruses are obligate intracellular parasites . They lack enzymes necessary for protein and nucleic acid synthesis and are dependent for replication on the synthetic machinery of host cells -4 so, they cannot grow in cell free culture media. . They do ...
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Serous epithelial tumor are the most common type of ovarian tumors.
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Ans. is 'a' i.e., Lamination "Commonest symptom is watering" -- MukherjeeIn Buphthalmoso Most common symptom - Watering (lacrimation)o 2nd most common symptom - Photophobiao Most troublesome symptom - Photophobia (Child avoids light)o First sign - Corneal edema with wateringo Haab striaeo Large corneao Deep anterior ch...
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Chicken pox is caused by varicella zoster virus ,a DNA virus of Herpes virus family . It is present in respiratory secretions and skin lesions of an affected child . The poal of entry is the respiratory tract. Secondary bacterial infections of skin lesions is fairly common and occasionally result in necrotising fasciti...
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Ans. is 'd' i.e., 6-8 weeksRef: Postgraduate anaesthesia p. 786'Limited prospective data suggest that cessation for at least 6-8 weeks preoperative is necessary to decrease the incidence of pulmonary complication."
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Postural hypotension cause by a-blockers is called first dose hypotension because tolerance occurs to this adverse effect on chronic use. On the other hand, adrenergic neuron blockers continue to produce ohostatic hypeension even on chronic use.
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The posterior interventricular aery, a branch of right coronary aery, supplies the posterior 1/3 of the interventricular septum. The remaining anterior 2/3 is supplied by the anterior interventricular aery which is a septal branch of the left anterior descending aery, which is a branch of left coronary aery . B D CHAUR...
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Ans. is 'c' i.e., Cardiac arrest Inducing mild therapeutic hypothermia in selected patients surviving out-of-hospital sudden cardiac arrest can significantly improve rates of long-term neurologically intact survival and may prove to be one of the impoant clinical advancements in the science of resuscitation. The types ...
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This patient is showing features of Vincent's angina, also known as acute necrotizing ulcerative gingivitis or trench mouth. It is a form of gingivitis characterized by painful, inflamed gingiva with ulcerations of the interdental papillae that bleed easily. It is caused by anaerobes. Treatment involves debridement and...
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Ans. (a) Hexoses(Ref: Ganong, 25th ed/p.477)Hexose is a monosaccharide with six carbon atomsD-glucose, D-galactose, and D-fructose are hexosesAbsorption is fastest and best for glucose
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The above image represents Orchidometer. It helps to assess the volume of testicules. Testicular size > 4cc in volume is the 1st sign of puberty in males.
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Medical certificate is the simplest type of written/documentary evidence.
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Ans: a (pKa)Ref: Vasudevan & Sreekumari, 6th edi., Pg. 340BUFFERS - are solutions which can resist changes in pH when acid or alkali is added.Composition of buffers - two typesMixtures of weak acid with their salt with a strong base. Mixture of weak bases with their salt with strong acid.Example-Carbonic acid and sodiu...
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Ans. d. Competitive and irreversible (Ref: Goodman Gillman 12/e p242. Katzung 12/e p106: KDT 7/e p99)The type of inhibition of acetyl cholinesterase caused by organophosphates is competitive & irreversible."Organophosphates cause irreversible inhibition of Acetyl-cholinesterase while that caused by carbamates is revers...
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GB syndrome Autoimmune - H/O -Post bacteria / viral - MC - C. Jejuni 2 wks.- C/L - Ascending symmetrical flaccid paralysis but bladder bowel-spared Dx - lumbar puncture - CSF (P) - Normal Cells - Normal Sugar - Normal Colour - Normal Proteins | Albumino-cytological dissociation IOC - AntiGM- Ab. Rx - IV Immunoglobulins
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FSH is required for development of large antral follicles in later stage, although not required for early follicular maturation.
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Suction airway of all babies- not recommended. 'Routine care' consists of : Provide warmth to all babies Proper positioning of baby Suction airways only if necessary Dry the baby Ongoing evaluation of vital parameters of all babies
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Mitochondrial DNA
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Congenital cataract is cause due to defects in CRY GS3 gene. During embryonic development, the PAX6 protein is thought to turn on (activate) genes involved in the formation of the eyes. Aniridia is caused by mutations in the PAX6gene. SIX 5-Mutations in this gene are a cause of branchiootorenal syndrome type 2. PITX 3-...
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Ans. C: 100 villages and 1,00,000 population Under the Community Development Programme, the rural areas of the country have been organized into Community Development Blocks-each block comprising approximately 100 villages and a population of 1 lakh Community development block It is a rural area earmarked for administra...
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ref : shaw gynecology
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Ref: R Alagappan - Manual of Practical Medicine 4th Edition.pg no:684 Lp (a) It consists of an apoprotein (a) molecule bound by sulfhydril link to the apolipoprotein B moiety of LDL paicle. Apoprotein (a) has homology with plasminogen and may inhibit fibrinolysis by competing with plasminogen. Thus it provides an impoa...
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Ans. is a i.e. 800cc
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A laryngocele is defined as an abnormal dilation or herniation of the saccule of the larynx. Secondary infection of a laryngocele is termed a laryngopyocele. Laryngoceles can be classified into three types: internal, external, and combined. A laryngocele is defined as internal if the dilation lies within the limits of ...
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Kyasanur forest disease (KFD)
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Ans. is 'a' i.e., Ca. stomach
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Barret's esophagus predisposes to adenocarcinoma.
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Ans. d (Erosion of femoral vessels) (Ref. Bailey and Love 26th/pg. 1375)CARCINOMA OF PENISAetiology# Circumcision6 soon after birth confers almost complete immunity against carcinoma of the penis.# Later circumcision does not seem to have the same effect and muslims circumcised between the ages of 4 and 9 years are sti...
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Most of these procedures fall under clean-contaminated or contaminated categories.
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Ans. is 'a' i.e., Tamsulocin
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Reference Robbins
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Biotechnology is the use of living systems and organisms to develop or make products, or "any technological application that uses biological systems, living organisms or derivatives thereof, to make or modify products or processes for specific use
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Production of ketone bodies by the livera. As glucagon levels rise, adipose tissue breaks down its triacylglycerol stores into fatty acids and glycerol, which are released into the blood.b. Through the process of b-oxidation, the liver converts the fatty acids to acetyl coenzyme A (acetyl CoA).c. Acetyl CoA is used by ...
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Hematuria is defined as the presence of red blood cells in the urine originating from the kidney or the urinary tract Underlying conditions producing hematuria, like diabetes, can be associated with progressive decline in kidney function in the setting of CKD Ref Harrison20th edition pg 278
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The resident is feeling the two pubic bones, which are joined at the midline by the symphysis pubis. Experienced obstetrician/gynecologists can often perceive the softening of the symphysis pubis that occurs during late pregnancy as a "springiness" of the pubic bones during palpation.The coccyx is the caudal terminus o...
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Most common Intraparenchymal brain tumor to show calcification is Oligodendroglioma(usually frontal lobes and shows chickenwire calcifications)
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Ans. B i.e. Placental site
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Complications of meningitis in children Seizure is the commonest complication of meningitis in children. It occurs in about 30% of patients. Other common complications of meningitis. Subdural empyema or effusions — It is commonly seen after meningitis with H. Influenza. rain Abscesses Neurological impairment → Hemip...
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A two-year-old with a tumor of the kidney most likely has Wilms tumor. This aggressive lesion (now with a 90% survival rate ) is microscopically interesting because it contains embryonic glomerular and tubular structures embedded in a spindle cell stroma which may also contain smooth muscle, striated muscle, bone, cail...
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Ans: A (Memantine) Ref: Goodman and Gilman's "Phannacologica! Basis of Therapeutics'' 12th eci p.622Explanation:Memantine* It is used either as an adjunct or an alternative to cholinesterase inhibitors in Alzheimer's disease, and is also commonly used to treat other neurodegenerative dementias,Memantine is a noncompeti...
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HBsAgAnti HBsAnti HBcHBeAgAnti-HbeInterpretation+-IgM+-Acute hepatitis B, high infectivity+-IgG+-Chronic hepatitis B, high infectivity+-IgG-+1. Late acute or chronic hepatitis B, low infectivity2. HBeAg-negative ("precore-mutant") hepatitis B(chronic or, rarely, acute++++/-+/-1. HBsAg of one subtype and heterotypic ant...
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Ans. is 'b' i.e., Amphoterecin B o In this question most probably the question has been wrongly framed. o None of the drugs given in the question inhibits synthesis of ergosterol. o Anyway, the drugs having any action on ergosterol is Amphotericin B.
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Leads II, III, and aVF detect Inferior wall ischemia. Inferior wall of hea is formed mainly by the major pa of right ventricle and left ventricles separated by the posterior interventricular groove, which is mainly supplied by the right coronary aery. Any block in RCA results in inferior wall and posterior 1/3rd of int...
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These patients with congenital adrenal hyperplasia require lifelong treatment. Patients with salt wasting and virilizing forms should be treated with hydrocortisone(10-15 mg/m2/day)and fludrocortisone (0.1mg/day). After completion of growth, synthetic glucocorticoid preparations( dexamethasone, prednisolone)can be used
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Ans. is 'b' i.e., Aldosterone
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Ans. is 'd' i.e., Horners syndrome can never be associated Klumpke's paralysis:* Site of injury: Lower trunk of the brachial plexus* Cause of injury : Undue abduction of the arm, as in clutching something with the hands after a fall from a height,or sometimes in birth injury.* Nerve roots involved: - Mainly T1 and part...
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Answer- C. Decreased excretion
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Atropine is an anti muscarinic drug diphenoxylate is an opoid drug which when given has propey of abuse hence atropine is added to it aas the anti muscarinic side effects of atropine will decrease the abuse of the drug. ReF:KDT 6/e p664
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Premature menopause Ovarian failure occurring 2 SD in years before the mean menopausal age in a population. It is clinically defined as secondary amenorrhoea for at least 3 months with | FSH level | FSH/LH ratio Low E2 level In a woman under 40 years of age. Average age of attaining menopause World = 51 years India = 4...
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Germ cell tumour
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Ans. B: Excessive salivationSjogren's syndrome is a chronic systemic disorder of idiopathic origin characterized by three major compo-nents:Keratoconjunctivitis siccaXerostomia andPolyahritis of rheumatoid origin occurring predominantly in women over foy years.There is immunologically mediated destruction of the lacrim...
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P. Alba Occurs predominantly in children( 3-16 years). Both sexes are equally susceptible. C/f: Lesion is rounded, oval or irregular plaque, which is red, pink or skin-coloured and has fine lamellar or branny scaling. - Initially erythema with minimal crusting, later erythema subsides and only show persistent fine scal...
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Differences b/w Human and Animal hair- Trait Human hair Animal hair General Fine & thin Coarse & thick Cuticle Scales sho, broad, flattened/ thin. Scales large, wavy projections/step-like projections. Coex Thick, 4-10 times as broad as medulla. Thin, rarely more than twice as broad as medulla Medulla Varies, narrow, co...
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Ans. Muller's muscle
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Ans. is 'b' i.e., Amputation of cervix * Fothergill's repair (Manchester operation): Main step is amputation of cervix.* Initially, the operation was thought to preserve the fertility status of the patient.* But as it is associated with a lot of complications, it is not a preferred option nowadays.* Various complicatio...
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Ref:Parks 23rd edition pg 139 Construct a 2x2 table using the above data. 4.75 4.75 0.25 9.25 PPV = TP / (TP + FP) = 4.75/(4.75+4.75)=0.5
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All stages from squamous metaplasia to carcinoma in situ are observed in squamous cell carcinoma. Such a clear progression is not seen in the other forms of cancer listed.
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Deep fascia is a dense layer of connective tissue that invests structures such as the muscles. Intermuscular septa are specific fascial planes that separate groups of muscles into different compaments, a concept that will be very impoant for understanding the limbs. Skin is the most superficial structure of the body, a...
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Above staining shows cuneiform arrangement/ chinese letter pattern of C. diphtheriae. C. diphtheriae- Gram-positive, highly pleomorphic organisms with paicular arrangement. Special stains like Neisser and Ponder's stain are used to demonstrate the metachromatic granules It is sensitive to the majority of antibiotics, s...
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Ans: B (Homicide) Ref: The Essentials of Forensic Medicine and Toxicology by KS Narayan Reddy, 29th edition, 2010, pg: 5Explanation:Inquest:It is an inquiry or investigation into the cause of death.It is conducted in cases ofo Suidde.o Murder.o Killing by an animal or machinery,o Accidents.o Deaths due to torture or il...
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Ans. is 'c' i.e., Sotalol "Sotalol is not metabolized in liver, excretion is predominantly by the kidney in the unchanged form". - Katzung 101Ve p. 229 Since it is primarly excreted in urine, it should not be used in renal failure. 0-blockers which are primarily excreted by kidney and should not be given in renal failu...
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CAMP is a secondary messager, used for intracellular signal transduction, such as transferring into cells the effect of hormones like glucagon etc.it is involved in activation of protein kinase Ref:Guyton and Hall textbook of medical physiology 12th edition,page number 540 ,541,542
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Astemizole and terfenadine are metabolized by microsomal enzymes. Erythromycin inhibits these enzymes and raises the plasma concentration of these drugs. At high levels, these agents block cardiac K+ channels leading to arrhythmias.
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Glycogen storage disease type I (GSD I) or von Gierke&;s disease, is the most common of the glycogen storage diseases. This genetic disease results from deficiency of the enzyme glucose-6-phosphatase and has an incidence in the American population of approximately 1 in 50,000 to 100,000 bihs. The deficiency impairs the...
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Ans. is 'a' i.e., Autosomal dominant disorder In Autosomal dominant disorders individuals are affected in successive generations. The disease does not occur in the offspring of unaffected individuals' ? Autosomal dominant o If both parents are normal, the disease cannot be autosomal dominant because it is manifested in...
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(Mucormycosis) (151 -Dhingra 4th)Mucormycosis - common in uncontrolled DM or taking immuno compressive drugs* Invade arteries an causes endothelial damage and thrombosis* Typical finding - presence of a black necrotic mass** filling the nasal cavity and eroding the septum and hard palate* Treatment - Amphotericin - B &...
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D i.e. Tibial collateral ligament Most knee ligament injuries occur while the knee is bent i.e. when the capsule and ligaments are relaxed and the femur is allowed to rotate on tibia. Injury to the medial (tibial) collateral ligament is the most common knee ligament injuryQ The medial structures are most often affected...
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Levonorgestrel is the best progesterone of choice for emergency contraception with least side effects.
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ASA Grading and Predictive Moality ASA Grade Definition Moality % I Normal healthy individual 0.06 II Mild systemic disease that doesn't limit activity 0.4 III Severe systemic disease that limits activity 4.5 IV Severe systemic disease that is constant threat to life 23 V Moribund, not expected to survive 24 hrs with o...
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Juvenile myoclonic epilepsy (JME) is an idiopathic generalised epileptic syndrome characterized by myoclonic jerks, generalized tonic-clonic seizures (GTCSs), and sometimes absence seizures. JME is relatively common and responds well to treatment with appropriate anticonvulsants. Ref : Ghai - 8th edition , pg no : 559 ...
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Cross infections occurring in hospitals are called nosocomial infections. Ref: Ananthanarayan& Paniker&;s textbook of microbiology, 9th edition. Pg no.71
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Smokers with COPD are at high risk for development of lung cancer, which can be identified on a chest CT scan. In advanced COPD, CT scans can help determine the possible  value of surgical therapy. The two main goals of therapy are to provide symptomatic relief (reduce respiratory symptoms, improve exercise tolerance, ...
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Ref: Clinical Oculor Pharmacology, 1st ed. pg. 257* Olopatadine hydrochloride is an antihistamine (as well as anticholinergic and mast cell stabilizer)* It is used as eye drop to treat itching associated with allergic conjunctivitis.* Side effects include headache, eye burning and/or stinging, blurred vision, dry eyes,...
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Answer- C. Lynch syndromeLynch syndrome is characterized by colorectal, endometrium and ovarian carcinomas.Hereditary non-polyposis colorectal cancer (HNPCC) syndromeIt is also known as Lynch syndrome. It is characterized by increased incidence of colorectal cancer and extraintestinal cancers (ovary and endometrium).Th...
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This patient has a high clinical likelihood of pulmonary embolism because clinical assessment score is more than 4:- Signs & symptoms of PE (Breathlessness & chest pain) → score 3.0 Immobilization (bed rest) > 3 days → score 1.5 So, the total score is 4.5. Therefore, imaging test should be done. CT contrast is the ...
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ANSWER: (A) Positive Trendelenburg's testREF: Essential Clinical Anatomy, Keith .L. Moore 4th edition p-348/354 Indirect repeat from June 2009"Positive trendelenburg's sign is seen in superior gluteal nerve (Gluteus medius & minimus) injury and not in Inferior gluteal nerve injury (Gluteus maxim us)"The main actions of...
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Bih rate = Number of live bihs during the year X 1000/ estimated mid year population Unsatisfactory measure of feility because the total population is not exposed to child bearing Reference : Park&;s textbook of preventive and social medicine, 23rd edition, Page no: 488
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Ans. is 'a' i.e., Cyclosporine Drugs used for Leishmaniasis (Kala azar) - Sodium stibogluconate (DOC), Pentamidine, Amphotericin B, Ketoconazole, Miltefosine, Paromomycin, Allopurinol.
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The combination of hyperkalemia and hyperchloremic metabolic acidosis is often present, even at earlier stages of CKD (stages 1-3).In patients with diabetic nephropathy or in those with predominant tubulointerstitial disease or obstructive uropathy; this is a non-anion-gap metabolic acidosis.
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Retrograde contraction by Anterograde relaxation by Acetycholine Substance P Serotonin NO Vasoactive Intestinal Peptide
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CO= 240 / (180-160) = 12 L/min To determine cardiac output by direct Fick's method, three values must be known: 1. O2 consumption of the body (measured by the rate of disappearance of oxygen from the respired air, using any type of oxygen meter) 2. O2 concentration in venous blood (a catheter inseed up the brachial vei...
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Since he has completed the course of tetanus toxoid and received a booster dose within 5 years nothing more is needed. If he had taken a booster dose more than 5 years ago and less than 10 years, 1 dose TT should have been given. If his last booster dose was > 10 years ago he needs both toxoid and immunoglobulin. Same ...
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Mallampati classification: Class I: The entire palatal arch, including the bilateral faucial pillars, are visible down to their bases. Class II: The upper pa of the faucial pillars and most of the uvula are visible. Class III: only the soft and hard palates are visible. Class IV: only the hard palate is visible.
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Ans. c. Hyperopia Rhegmatogenous Retinal Detachment A rhegmatogenous retinal detachment (RRD) occurs when a tear in the retina leads to fluid accumulation with a separation of the neurosensory retina from the underlying RPE MC type of retinal detachment Pathophysiology: Vitreoretinal traction is responsible for the occ...
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Answer is C (Hypeension): Addison's disease is associated with hypotension & not hypeension. 'Aerial hypotension with postural accentuation is frequent and blood pressure may be in the range of 80/50 mmHg or less' - Harrison 16th/2142 Addison's disease: Review Addison's disease or primary adrenocoical deficiency is cha...
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Paramyxoviruses are negative sense single stranded Enveloped RNA viruses Site of riboncleoprotein synthesis is cytoplasm and envelop is derived from host cell plasma membrane They are important pathogens of infants and children and responsible for major part of acute respiratory infections and Infection is acquired by ...
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Ans. A. Genomic Imprinting(Ref: Robbins 9/e page 172)Studies over the past two decades have provided definite evidence that, at least with respect to some genes, important functional differences exist between the paternal allele and the maternal allele. These differences result from an epigenetic process called imprint...
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Ans. B. 20 weeksa. MTP is permitted up to 20weeks of pregnancy. When the pregnancy exceeds 12weeks, opinion of two medical practitioners is required.b. Husband's consent is not necessary for MTP.
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On the basis of above clinical scenario best possible diagnosis is Maxillary sinusitis. Conventional Criteria for the Diagnosis of Sinusitis Based on the Presence of at Least 2 Major or 1 Major and >=2 Minor Symptoms MAJOR SYMPTOMS MINOR SYMPTOMS Purulent anterior nasal discharge Purulent or discolored posterior nasal ...
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PDH COMPLEX - three enzymes (1 ) pyruvate dehydrogenase (E1), (2) dihydrolipoyl transacetylase (E2) (3) dihydrolipoyl dehydrogenase (E3) FIVE COENZYME - VITAMIN B1 , B2 , B3 , B5 , COA, LIPOIC ACID Any oxidative decarboxylation reaction in body require vitamin B1 so here answer is the vitamin b1
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Implantation can be defined as the process by which the blastocyst penetrate the epithelium and then the circulatory system of the mother It occurs 7-9 days after feilization Reference: Textbook of Obstetrics; Sheila balakrishnan; 2nd edition; Page no: 57
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Ans. is 'd' ie Transrectal U/S "TRUS (Transrectal U/S) remains the most accurate method of staging the local disease (prostatic cancer)/' - Bailey & Love
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most common site of gastrinoma is passaro triangle or gastrinoma triangle Zollinger-Ellison syndrome I Clinical manifestation hypergastrinaemia caused gastrynoma: gastrin-producing tumor (1 or more) of the pancreas, colon, duodenum , peripancreatic lymph nodes, G-cells of the gastric mucosa (triangle gastrin) I Spread ...
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Chdecystocaval line Line drawn from IVC and gall bladder divides liver into 2 halves - right and left lobes.
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low rennin levels 1 Ref Harrison 17th/e p 2264, 2263 & 16th/e p 2142] The normal serum coisol ranges between 5-23 lug/dl In addison's disease the coisol level is usually below (< 3 pg/dL). Patients tend to be hypotensive and ohostatic, about 90% have systolic blood pressure under 110 mm Hg. Diastolic blood pressure is ...
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CD4 T cells are helper T cells. They stimulate B cells to produce antibodies, release of cytokines and are responsible for memory. They do not directly produce any antibody by their own. Basic Pathology, Robbins. Page no.:101
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Ans. All of the above
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Answer is A (HBV DNA) HBV DNA is the most sensitive marker of active Hepatitis B virus replication `HBV DNA is the most sensitive marker of virus replication. The detection of HBV DNA as the most sensitive marker of virus replication end as such proof of infectivity has replaced the determination of DNA polymerase' -- ...
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