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According to first order kinetics of elimination the rate of elimination of a drug is directly propotional to the drug concentration. Clearence of the drug remains constant and a constant fraction of drug is eliminated in unit time. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 27-8
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It can also refer to an infant who is not feeding enough to receive the necessary nutrition required for adequate growth. Poor growth associated with lack of feeding can lead to a separate condition called failure to thrive. No matter what the precise cause of poor feeding, undernutrition is a top concern. Reference: G...
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Induced hypothermia is used for neurosurgery, carotid artery surgery, cardiac surgery, traumatic brain injury, ARDS, malignant hyperthermia, Prolonged surgeries, neonatal encephalopathy caused by birth asphyxia. Hypothermia induces arrhythmia, so it cannot be used in arrhythmia.
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Prepalcement examination in dye industries include asthma,skin and bladder,kidney diseases,precancerous lesion.Anemia comes under lead.(Ref.PARK'S textbook of preventive and social medicine 21st edition page no.753)
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Coisol provides the body with glucose by tapping into protein stores gluconeogenesis in liverCauses the release of the amino acid from muscle Ref: DM Vasudevan, 7th edition, page no: 313
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Meningococal Meningitis Causative agent : N.meningitidis,a gran negative diplococci Serotypes A, B, C, D, 29E,W135,X,Y World wide Group A is the MC cause of Meningococcal Epidemics (except in America), especially in Sub saharan African belt Recently Group B, W-135, Y cases have staed increasing in World Epidemics cause...
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Absorbable suture materials are: plain catgut, chromic catgut, vicryl ( polyglactic acid),dexon(polyglycolic acid), maxon(polyglyconate), PDS( poly dioxanone suture material ), monocryl, biosyn.Non absorbable suture materials are silk, polypropylene (prolene), polyethylene, cotton, linen, steel, polyester, polyamide, n...
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Answer is D (Tracheal shift to side of consolidation): Trachea stays in midline in consolidation (no mediastinal shift). Consolidation is usually caused by pneumonia. In this situation alveoli are full of inflammatory exudates but the size of the lung is unaffected so the trachea remains in its normal midline position.
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Emergency contraception(EC) is based on the fact that protection is provided within 72 hours of unprotected intercourse. Mifepristone and LNG are proven easily administered oral therapy for EC whereas Cu T can be used effectively and cost effectively even till the fifth day after unprotected intercourse. However, LNG i...
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Haab striae are seen in buphthalmos ( congenital glaucoma ). These are curvilinear healed breaks in Descemet membrane. Buphthalmos is a large eye as a result of stretching due to elevated IOP prior to the age of 3 years. Ref: kanski's clinical ophthalmology, 8th edition, page no.386
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D i.e. Can cause secondary drowning
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Lymphoedema characteristically involves the foot.The contour of the ankle is lost through infilling of the submalleolar depressions, A 'buffalo hump' forms on the dorsum of the foot,The toes appear 'square' because of confinement of footwear and The skin on the dorsum of the toes cannot be pinched because of subcutaneo...
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Ans is 'a' i.e. PAX8- PPARrl Various genes involved in thyroid carcinomas arePapillary* Tyrosine kinase receptors RET or NTRK1* RAS mutation* BRAF oncogeneFollicular* RAS oncogene (NRAS, HRAS and KRAS* PAX8- PPARrl translocationMedullary* RET proto-oncogene
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DYSTROPHIC CALCIFICATION METASTATIC CALCIFICATION Seen in Dead/Degenerative tissue Seen in Living tissue Affected Patients will have normal serum Ca2+ Affected Patients will have Hypercalcemia Causes of dystrophic calcification TB Chronic abscess Infarcts Atherosclerosis Hematoma Tumors like meningioma,mesothelioma Myo...
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Ans. D: Collecting ducts Because one of its principal physiologic effects is the retention of water by the kidney, vasopressin is often called the antidiuretic hormone (ADH). It increases the permeability of the collecting ducts of the kidney, so that water enters the hypeonic interstitium of the renal pyramids. The ur...
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Dopamine is produced from L-dopa, which in turn is made from tyrosine. Therapy with the L-dopa precursor increases dopamine concentrations and improves the rigidity and immobility that occur in Parkinsons disease. Dopamine is degraded in the synaptic cleft by monoamine oxidases A and B (MAO-A and MAO-B), producing 3,4-...
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In high small bowel obstruction there is rapid vomiting and dehydration. Ref: Bailey & Love 25/e, Page 1193.
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Telomers are short repeated sequence of DNA at the end of chromosomes. In normal somatic cells, telomers get shortened in each replicated cycle, and after telomers are shortened by a critical length, cell stops dividing and enters into senescence (Go phase). However, Germ cells, cancer cells and stem cells have an enzy...
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Answer is C (Pharyngeal diveiculum) Progressive Achalasia Progressive systemic sclerosis Peptic stricture Carcinoma Intermittent Lower esophageal ring/Spatzki ring Diffuse esophageal spasm Zenker's diveiculum
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Ans. C: Slit smear for AFB Tissue smear testing/slit-skin smears. An incision is made in the skin, and the scalpel blade is used to obtain fluid from a lesion. The fluid is placed on a glass slide and stained by using the Ziehl-Neelsen acid-fast method or the Fite method to look for organisms. The bacterial index (BI) ...
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D i.e. After 6 hours Inveogram is done to detect imperforate anusQ. It is done after six hours of bihQ in infant as sufficient air may have collected in large intestine to cast a x Ray Shadow. If the distance between highest level of gas in rectum & metal bougie inseed into the blind anal canal is > 2.5 cmQ; the abnorm...
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CD 103
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Ans. is 'c' i.e. RNA dependent DNA polymerase The Characteristic biochemical feature of retroviruses is the presence of RNA dependent DNA polymerase (reverse transcriptase)o Wrhen the virus infects a cell, the viral RNA is transcribed by reverse transcriptase, first into single stranded DNA and then to double stranded ...
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Levator palpetore superioris - muscle of orbit.
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In POTT'S shunt: The descending aoa is anastomosed to pulmonary aery. Operative treatment of TOF consist of two types: Palliative and Definitive. Palliative treatment consist of anastomosing systemic aery and pulmonary aery to increase the pulmonary blood flow and thus increase amount of oxygenated blood reaching syste...
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Answer is A (Does not respond to chemical stimuli): Ventilatory responses to chemical stimuli are reduced or absent- Harrison 161/1/1570 Primary pulmonary hypoventilation Characterized by: Impaired chemoreception resulting in decreased ventilatory drive. Chronic hypercapnia and hypoxemia in the absence of identifiable ...
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Celiac disease (celiac sprue / gluten-sensitive enteropathy) Celiac disease is a chronic disease, in which there is a characteristic mucosal lesion of the small intestine and impaired nutrient absorption, which improves on withdrawal of wheat gliadins and related grain proteins from the diet. The fundamental disorder ...
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Ref Robbins 9/e p153 Gaucher's disease_ pain in bones, hepatosplenomegaly,splenic biopsy having crumpled paper appearance
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Flexor tendon tenosynovitis is a frequent hallmark of RA and leads to decreased range of motion, reduced grip strength, and "trigger" fingers. Progressive destruction of the joints and soft tissues may lead to chronic, irreversible deformities. Ulnar detion results from subluxation of the MCP joints, with subluxation o...
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Ans. is 'd' i.e., Methionine "Pulses have high lysine content and are deficient in methionine; on the other hand cereals have an abundance of methionine"
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Axillary vessels are enclosed by prevertebral fascia.
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Attention deficity hyperactivity disorder (ADHD) ADHD is one of the most common psychiatric problems in school-age population. It is three times more common in boys than girls. ADHD is characterized by an age inappropriate hyperactivity, impulsiveness and inattenton. Hyperactivity is usually the first symptom to be n...
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Ans. is 'b' i.e Ca prostate Metastasis in bone may produce osteolytic lesion or osteoblastic (osteogenesis) lesion. Most metastatic lesions produce both types of lesions and may go through stages where one or other predominate, Although some tumors mainly produce osteolytic lesion---- Renal cell Ca*. And some mainly os...
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Ans. is a, i.e. Continue the pregnancy for at least one weekIf delivery can be postponed for at least 7 days, the mother will develop antibodies and there will be transplacental transfer of antibodies to the neonate. The neonate will have passive immunity and will not develop the infection. Therefore, the best method t...
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Post-anaesthesia shivering (PAS)Post anaesthesia (postoperative) shivering occurs in 40% of patients recovering from general anaesthesiaSometimes it is preceded by central hypothermia and peripheral vasoconstriction, indicating that it is a thermoregulatory mechanismPethidine is most effective drug for treatment of PAS...
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Ans. (a) 50% of boys of carrier mother are affected(Ref: Robbins 9th/pg 141; 8th/pg 141)In a X linked recessive disorder, if father is normal & mother is a carrier:In such a situation,50% of the sons are affected50% of daughters are carriers, but none of the daughters are affectedMother transmits the disease to the son...
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Ref: Grays Anatomy 40th edition pg: 410Explanation:Foramen OvaleCommunicates with infratemporal fossa* Motor root of Trigeminal nerve* Sensor root of Mandibular nerve* Accessory meningeaiartery* Lesser Petrosal nerve* Emissary vein connecting cavernous sinus with pterygoid venous plexusMnemonic: T-MALEForamen spinosum*...
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The picture shows the drug inhibiting the release of acetylcholine into synapse.so it is either botulinum or beta bungaro toxin Ref: KD Tripathi 6th ed pg 94
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The presence of a lung mass suggests carcinoma. The small size of the neoplastic cells suggests that the tumor may be small cell carcinoma (oat cell carcinoma). The other possibility on morphologic grounds is lymphoma, but lymphoma can be excluded by the negative LCA study. The oncogene associated with small cell carci...
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Ans. is `d' i.e., Frame method Age from teeth after 20 years Teeth eruption is useful for age estimation upto about 18 years, beyond which it is just a guess work. The methods used are :? A. Gustafson's method : Useful only in persons older than 21 years of age, depending on the physiological changes in each of the den...
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Excessive radiation exposure has adverse effects on health.Effective protective measure include proper use of lead shields and rubber aprons. Lead aprons of 0.5 mm of lead will reduce the intensity of scattered X rays over 90 % and could be worn by al workers regularly associated with X ray procedures. Parks textbook o...
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Osteocalcin Osteocalin is a non-collogenous protein secreted by osteoblasts. It is thought to play a role in mineralization and calcium ion hemostasis. "Thus it is a bone formation marker i.e. osteoblastic marker". A large number of studies have shown that the circulating level of osteocalcin reflects the rate of bone ...
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Dilator pupillae muscle is suppliedby the postganglionic fibers arising from the cervical sympathetic chain. ... Oculomotor nerve supplies the skeletal as well as the smooth muscles of the eyeball. It carries the pre-ganglionic fibers from the Edinger-Westphal to supply two smooth muscles in the eyeball Ref AK khurana ...
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Ans. is 'b' i.e., Width of blade o Length of the stab wounds is slightly less than the width of the weapon upto wrhich it has been driven inside,o Deliberate lateral, forward or backward movement of the weapon during its withdrawal from the body tends to widen the wound, and the length will be more than the actual widt...
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Ans. D. Deep SleepEEG waves:Delta:a. It has a frequency of 3Hz or below.b. It tends to be the highest in amplitude and the slowest waves.c. It is normal as the dominant rhythm in infants up to one year and in stages 3 and 4 of sleep.d. It may occur focally with subcortical lesions and in general distribution with diffu...
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Minimum alveolar concentration (MAC) - Measure of potencyBlood: Gas paition coefficient -Blood solubility of anaesthetic agent and determines the speed of induction & recoveryOil: Gas paition coefficient - Lipid solubility of anaesthetic agent and is related to potency of anaesthetic agent.(Refer: Morgan and Mikhail's ...
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Warfarin is a coumarin anticoagulant used for the prophylaxis and treatment of thromboembolic complications associated with cardiac valve replacement and atrial fibrillation, as well as the prophylaxis and treatment of venous thrombosis and pulmonary embolism. Warfarin may cause necrosis of the skin (typically on the b...
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Following IPCs: 191Deals with false evidence and is based upon recognition of decline of moral values and erosion of sanctity of oath. 192Fabricating false evidence. The wording of this Section is so general as to cover any species of crime that consists in the endeavour to injure another by supplying false data. 193 P...
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Ans. is 'b' i.e., Contralateral optic atrophy Foster Kennedy Syndrome||lpsilateral (Direct Compression)Contralateral (Indirect)o Anosmia due to direct compression of the olfactory bulb or tract,o Optic atrophy and central scotoma due to pressure on optic nerve on the side of lesion,o Homolateral optic atrophy (due to d...
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Objective of WHO Oral Global Health by 2000: 50% of the 5-6 years old should be caries free. Global average should be no more than 3 DMF at age 12.   85% of population should retain all their teeth by age 18. A 50% reduction in edentulousness in present levels at age 35-40 years should be achieved.   A 25% reduction i...
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Recent studies have demonstrated that markers of inflammation correlate with coronary risk and that inflammation plays a role in atheromatous plaque instability. Elevations of C-reactive protein, (CRP) identify patients at increased risk of myocardial infarction (MI) and poor outcome of acute coronary syndromes. Measur...
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Apoptosis is a pathway of cell death in which cells activate enzymes that degrade the cells' own nuclear DNA and nuclear and cytoplasmic proteins. Fragments of the apoptotic cells then break off, giving the appearance that is responsible for the name (apoptosis, "falling off"). The plasma membrane of the apoptotic cell...
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Cerebellar fibers (dentatothalamic) project to the Ventral Lateral Nuclei of thalamus, which in turn project to the motor coex (area 4).
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<p>Reticulocytosis occurs in conditions of rapid cell regeneration such as after hemorrhage ,hemolysis, hematopoietic response of anaemia to treatment .But in anemia of chronic renal failure there is defective red cell production & reticulocyte count is generally low. </p><p>Reference : Hardh Mohan textbook of patholog...
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One form of hepatic adaptation includes drug induced hyperbilirubinemia , it is seen with rifampicin,flavaspidic acid,cyclosporine. Ref : Schiff's diseases of liver , Edition -11 , Page - 715.
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.<p>evaluation of a screening test is done by*specificity,*sensitivity,*predictive value of a positive test,*predictive value of a negative test,*percentage of false negatives,*percentage of false positives etc.</p><p>ref:park&;s textbook of preventive and social medicine,22 nd edition ,pg no 131</p>
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The syndrome represented by the clinical vignette is infectious mononucleosis. Epstein-Barr virus (EBV) is the usual cause of heterophile-positive infectious mononucleosis; cytomegalovirus is responsible for a minority of cases. Rarely, splenic rupture requiring splenectomy can result from splenomegaly and capsular swe...
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D ie Paial trisomy of 22
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LKM2 - chronic hepatitis D LKM stands for liver kidney microsomal antibodies. Type of LKM antibody Conditions associated Anti LKM, antibodies_____ ___________ -4 Chronic hepatitis C, Autoimmune hepatitis type 2 Anti LKM2 antibodies --> Drug induced hepatitis Anti LKM3antibodies --> Chronic hepatitics D, Infrequently po...
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C i.e. Dilation in both pupils
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Golgi tendon organs are in series with the muscle fibers, they are stimulated by both passive stretch and active contraction of the muscle, when  tension increases inside muscle.
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Vasopressin acts on V3 or V1b receptors to release ACTH.
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Medullary Ca Arises from parafollicular cells or 'C' cells Associated with secretion of calcitonin. Associated with amyloid deposition. Standard marker is Calcitonin. In calcitonin negative medullary thyroid Ca - Tumor marker is carcinoembryonic Ag Familial medullary thyroid carcinomas In MEN-2 Associated with germline...
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Elevated erythropoietin leves are seen in Hemolytic anemias.
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Clinical features of HCC Most common symptom is abdominal pain >weight Significant weight loss : <5% in 1 month or 10% in 6 months or 20% in 1 year Usually presents at late stage, symptoms at advanced stage are vague Non-specific symptoms( anorexia, weight loss) and hepatomegaly Paraneoplastic syndromes in HCC - Hyperc...
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Most lung volumes are measured by Spirometer. Residual volume, total lung capacity, and functional residual capacity cannot be measured with a spirometer.Ref: Ganong review of medical physiology 23rd edition Page no: 593
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Ans. is 'd' i.e., Vit C deficiencyPseudoparalysis o A voluntary restriction of motion because of pain, incordination or other cause, but not due to actual muscular paralysis.Causes of pseudoparalysisScurvy (vitamin C deficiency) o OsteomyelitisSeptic (ahritis) o Congenital syphilis
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park'stextbook of preventive and social medicine 23rd edition. *heat cramps occur in persons who are doing heavy muscular work in high temperature and humidity . *there are painful and spasmodic contractions of skeletal muscles *cause is the loss of sodium and chlorides in the blood.
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C i.e. Deamination of cytidine to uridine IRef: Vasudevan - Least post translational modification occurs in prokaryotic mRNA, which is generally identical to its primary transcript. Post translational modification of t-RNA includes removal of introns from anticodon loop, trimming of 5' & 3' ends, methylation / reductio...
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In esophageal varices, the esophageal folds are thick and tortuous, giving rise to a wormy or worm-eaten appearance. The radiographic picture would vary with the severity of the varices, as well as the distention of the esophagus. When varices are severe, they should be appreciated in any projection. The left anterior ...
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(Hashimoto's thyroiditis): Ref: 957-LB, 2117-H (799-B &L 25th)Hashimoto's Thyroiditis (Struma-lymphomatosa or diffuse lymphocytic thyroiditis, goitrous autoimmune thyroiditis, autoimmune chronic lymphocytic)* The most common clinically apparent cause of chronic thyroiditis is hashimoto's thyroiditis, an auto immune dis...
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Bear claw sign is seen in liver trauma on CECT Note- Bear paw's sign- xanthogranulomatous pyelonephritis.
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Causes of acquired cerebral palsy may include1,2: Brain damage in the first few months or years of life. Infections, such asmeningitis or encephalitis. Problems with blood flow to the brain due to stroke, blood clotting problems, abnormal blood vessels, a hea defect that was present at bih, orsickle cell disease. A cer...
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The epulis fissuratum is a tumorlike hyperplasia of fibrous connective tissue that develops in association with the flange of an ill-fitting complete or partial denture. Although, the simple term 'epulis' sometimes is used synonymously for epulis fissuratum, epulis is actually a generic term that can be applied to any ...
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harshmohan textbook of pathology 7th edition. *the pathogenesis of HIV infection is largely related to the depletion of CD4 + T cells resulting in preformed immunosuppression .Selective tropism for CD4+ molecule receptors, gp 120 envelope glycoprotein of HIV has selective tropism for the cells containing CD 4 molecules...
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Answer is A (Karyotyping) : A ,female phenotype along with amenorrhea, absent uterus and sho blind vagina may result from either : - Female (XX) with mullerian agenesis or - Male pseudo-hermophrodite (XY) - Karyotyping is the investigation of choice, to make such a distinction
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Ans: a (B cells) Ref: Robbins,7th ed, p. 199; Ananthanarayan, 7th ed, p. 125When B lymphocytes are activated by antigens (protein/non-protein) they get differentiated into antibody secreting cells, called plasma cells.Plasma cells:Cartwheel appearanceLifespan-2-3 daysMakes Ab of single specificity, single Ig clan & all...
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Refer KDT 6/e p 236 It is an ergot alkaloid and is a Dopamine agonist Dopamine acts as prolactin inhibiting hormonal big the brain Agonism of Dopamine receptors by Bromocriptine is responsible for it's use in hyperprolactinemia
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Ans. is 'd' i.e., Any dehydration
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Ans. is 'a' i.e., Anogenital wart Treatment options in wartsType of wartsTreatment optionsVarruca vulgarisCryotherapyElectric cautery, RFAWart paint (non on face, anogenital region)Mechanical removalPalmoplantar wartsWart paintCryotherapyFormain soaksFiliform wartsElectric cautery, RFAPlane wartsTrichloracetic acid tou...
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Ans: B i.e. Apex of lungsSecondary pulmonary TB classically involves the apex of the upper lobes of one or both the lungsProgressive primary TB more often resembles an acute bacterial pneumonia, with lower and middle lobe consolidation, hilar adenopathy, and pleural effusion; cavitation is rare.
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Ans. is "d' i.e., Greater sac and lesser sac o Epiploic foramen (foramen of winslow or aditus to lesser sac) is a slit-like opening through which lesser sac communicates with greater sac. It is situated at the level of T12 vertebra. Its boundries are# Anterior:- Right free margin of lesser omentum (contains portal vein...
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3/8th of circle
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GREAT SAPHENOUS VEIN:- Lie on the dorsum of the foot.Recieves 4 dorsal metatarsal veins.Formed by union of medial end of dorsal venous arch with the medial marginal vein and drains the medial side of great toe.Passes upwards of medial malleolus (2.5cm in front) ,crosses the lower one-third of the medial surface of the ...
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Harshmohan textbook of pathology 7th edition. histamine: is a vaso active amine stored in the granules of mast cells, basophils and platelets. Histamine is released from the cell by various stimuli. .
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Ans. a. Fluorescent in-situ hybridization (Ref: Harrison 19/e 83e-2 , 83e-2f, 83e-3t p512; style="font-size: 1.04761904761905em; font-family: Times New Roman, Times, serif; margin: 0 0 0 8px; text-indent: 0">Exact location of a genetic loci is identified by Fluorescent in-situ hybridization (FISH).Fluorescent in-situ h...
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Adequate treatment: Patients has received 6 months of PBL therapy in 9 months or 12 months of MBL therapy within 18 months Multi drug therapy (MDT) of Leprosy: Paucibacillary Leprosy (PBL) Multibacillary Leprosy (MBL) No. of skin lesions <= 5 >= 5 Nerve involvement 0-1 nerve >= 1 nerve Treatment Day 1: Supervised month...
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Stress echo has the same technique used to acces the hea function at rest with a stressor as exercise or dobutamine infusion. It can cause emergence of regions of akinesis or dyskinesis not present at rest.IT Is primarily indicated to confirm the suspicion of ischaemic hea disease and to estmate its severity. Response ...
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Ans. is C. First investigation is USG>Xray Abdomen IOC is CT Gold standard investigation for renal calculi: Non contrast CT scan
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Ans: b. Before staing....Investigation of an Epidemic aln Steps Park 23rd/ 131-33Verification of diagnosisConfirmation of existence of an epidemicDefining the population at-riskRapid search for all cases & their characteristicData analysisFormulation of hypothesesTesting of hypothesesEvaluation of ecological factorsFuh...
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Cadaveric spasm occurs immediately after death and affects voluntary muscles.
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Minus desk
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Cholagogues are the substances that increase the bile flow by causing gall bladder contraction. CCK is a cholagogue. Vagus nerve, bile acids are choleretics; they increase the bile secretion from liver.
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Ans. is. 'c' i. e., Bronchoscopes
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Bupivacaine is more cardio toxic than Lignocaine as it more prone to prolong QTc interval and induce ventricular tachycardia or cardiac depression- should not be used for intravenous regional anesthesia. It has high lipid solubility: distributes more in tissues than in blood after spinal or epidural injection . Therefo...
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Replenishment of NAD is important because, it helps to sustain glycolysis in anaerobic conditions
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A i.e. Micromovement; B i.e. Muscle interposition; C i.e. Hypoxia
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Multiple foci and lymph node involvement are much less common than in papillary carcinoma. Papillary carcinoma is the most common thyroid malignancy.Blood-borne metastases are more common Moality rate, although low, is twice that of papillary cancerRef: Bailey and love, page no: 818
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Ans: d (ILD)Ref: Harrison, 17th ed. pg. 1646ILD is a restrictive lung disease characterized by decrease in both total lung capacity as well as residual volume.ParameterObstructive lung diseaseRestrictive lung diseaseTotal lung capacityNormal to IncreaseDecreasesResidual volume VitalIncreasesDecreasescapacity FEV,/FVCDe...
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