doc_id int32 18 2.25M | text stringlengths 245 2.96k | source stringlengths 38 44 | __index_level_0__ int64 18 2.25M |
|---|---|---|---|
828,674 | Secondary ion mass spectrometry (SIMS) was one of the first matrix-free desorption/ionization approaches used to analyze metabolites from biological samples. SIMS uses a high-energy primary ion beam to desorb and generate secondary ions from a surface. The primary advantage of SIMS is its high spatial resolution (as small as 50 nm), a powerful characteristic for tissue imaging with MS. However, SIMS has yet to be readily applied to the analysis of biofluids and tissues because of its limited sensitivity at >500 Da and analyte fragmentation generated by the high-energy primary ion beam. Desorption electrospray ionization (DESI) is a matrix-free technique for analyzing biological samples that uses a charged solvent spray to desorb ions from a surface. Advantages of DESI are that no special surface is required and the analysis is performed at ambient pressure with full access to the sample during acquisition. A limitation of DESI is spatial resolution because "focusing" the charged solvent spray is difficult. However, a recent development termed laser ablation ESI (LAESI) is a promising approach to circumvent this limitation. Most recently, ion trap techniques such as orbitrap mass spectrometry are also applied to metabolomics research. | https://en.wikipedia.org/wiki?curid=1029211 | 828,228 |
2,155,973 | In addition to widespread poverty, the country faces other challenges: the need to develop the rule of law; the high cost of combating drug trafficking and terrorism on its border; low Internet penetration (16% of the population in 2013) and a small domestic market. The government sector is not structured to meet the demands of a market economy and development plans and strategies are neither interconnected nor vertically integrated. Potential partners in the private sector and civil society are insufficiently implicated in the development process. To compound matters, the modest allocation of financial resources is frequently inadequate to reach the goals set forth in national strategic documents. The country is also plagued by inadequate statistics. These factors affect the implementation of the "National Development Strategy" for 2005−2015, which was designed by President Emomalii Rahmon to help the country meet the Millennium Development Goals. | https://en.wikipedia.org/wiki?curid=54245572 | 2,154,742 |
327,867 | Monk had disappeared from the scene by the mid-1970s for health reasons and made only a small number of appearances during the final decade of his life. His last studio recordings as a leader were made in November 1971 for the English Black Lion label, near the end of a worldwide tour with the Giants of Jazz, a group which included Gillespie, Kai Winding, Sonny Stitt, Al McKibbon, and Art Blakey. Bassist McKibbon, who had known Monk for over twenty years and played on his final tour in 1971, later said: "On that tour, Monk said about two words. I mean literally maybe two words. He didn't say 'Good morning,' 'Goodnight,' 'What time?' Nothing. Why, I don't know. He sent word back after the tour was over that the reason he couldn't communicate or play was that Art Blakey and I were so ugly." A different side of Monk is revealed in Lewis Porter's biography, "John Coltrane: His Life and Music"; Coltrane states: "Monk is exactly the opposite of Miles [Davis]: he talks about music all the time, and he wants so much for you to understand that if, by chance, you ask him something, he'll spend hours if necessary to explain it to you." Blakey reports that Monk was excellent at both chess and checkers. | https://en.wikipedia.org/wiki?curid=84250 | 327,693 |
989,886 | In a project sponsored by the DOE and operated by UOP LLC in collaboration with faculty from four different universities, MOFs were tested as possible carbon dioxide removal agents in post-combustion flue gas. They were able to separate 90% of the CO from the flue gas stream using a vacuum pressure swing process. Through extensive investigation, researchers found out that the best MOF to be used was Mg/DOBDC, which has a 21.7 wt% CO loading capacity. Estimations showed that, if a similar system were to be applied to a large scale power plant, the cost of energy would increase by 65%, while a NETL baseline amine based system would cause an increase of 81% (the DOE goal is 35%). Also, each ton of CO avoided would cost $57, while for the amine system this cost is estimated to be $72. The project ended in 2010, estimating that the total capital required to implement such a project in a 580 MW power plant was 354 million dollars. | https://en.wikipedia.org/wiki?curid=12637359 | 989,369 |
170,152 | Often, many colleges and universities in the United States will compete with their teams in what is known as a tournament. In the tournament, from eight, 16, 32, 64, 75, or more individual wrestlers/teams can compete in each bracket. This allows many schools to establish their rankings, not only for individual student-wrestlers, but also for college and university wrestling teams as a whole (e.g. a conference or regional championship, or the NCAA Division I Wrestling Championships). A tournament committee usually administers the event and after individual and team entries have been verified, the officials then determine the order of the matches (called "drawing") by certain brackets (e.g. brackets of eight, 16, etc.). The tournament officials when doing this drawing take into account each wrestler's win–loss record, previous tournament placements, and other factors that indicate the wrestler's ability. With that in mind, wrestlers who are noticed as having the most superior records are bracketed so that two top-ranked superior wrestlers in each weight class do not compete against each other in an early round. This is called seeding. Tournaments are often sponsored by a college or university and are usually held on Friday, Saturday, Sunday, or over any of two days within the weekend. Admission is often charged to cover costs and make a small profit for the host. A tournament begins with weigh-ins starting two hours or less before competition begins on the first day or one hour or less before competitions begins on any subsequent day. An allowance of one pound is granted for each subsequent day of the tournament. | https://en.wikipedia.org/wiki?curid=622572 | 170,062 |
407,312 | Gerbner's model was first published by George Gerbner in his 1956 paper "Toward a General Model of Communication". It is a linear transmission model. It is based on the Shannon–Weaver model and Lasswell's model but expands them in various ways. It aims to provide a general account of all forms of communication. An important innovation is that it starts not with a message or an idea but with an event. The communicating agent perceives it and composes a message about it. For Gerbner, messages are not packages that exist prior to communication. Instead, the message is created in the process of encoding and is affected by the code and the channel. Gerbner assumes that the goal of communication is to inform another person about something they are unaware of. He includes a total of ten essential components: (1) someone (2) perceives an event (3) and reacts (4) in a situation (5) through some means (6) to make available materials (7) in some form (8) and context (9) conveying content (10) of some consequence. Each of these components corresponds to a different area of study. For example, "communicator and audience research" studies the first component while "perception research" is concerned with the second component. In Gerbner's example, "a man notices a house burning across the street and shouts 'Fire!'". In this case, "someone" corresponds to the man and the perceived event is the burning house. Other components include his voice (means) and the fire (conveyed content). | https://en.wikipedia.org/wiki?curid=33742208 | 407,111 |
1,950,967 | In the appendix he elaborated on comments in the main text on how artificial selection—the elimination of trees of poor timber quality from the breeding stock—could be used to improve timber quality, and even create new varieties of trees. He extrapolated from this to what is today recognised as a description of natural selection. Although his book was reviewed in several periodical publications of the time, the significance of Matthew's insight was apparently lost upon his readers, as it languished in obscurity for nearly three decades. The only library in Perth at the time banned the book. Despite the suggestion that this through the librarian, "having no doubt spotted its hidden heresy", considering the historical context, it is more likely that the heretical content would be seen as the attacks on Sir Walter Scott, Paley's teleological immutability by Special Creation, and his other gripe, nobility and entail. Of Paley's Theological Naturalism, alternatives from Buffon transformatism and Lamarck unguided evolution still assumed a divine Creator. There is nothing to say Matthew was any different, such as evidence of him being an atheist (quite the opposite in fact). Also, Matthew's dealings in Perthshire, his personal and political opinions made public, were sometimes not well received. | https://en.wikipedia.org/wiki?curid=54486030 | 1,949,846 |
259,958 | The S-3 was removed from front-line fleet service aboard aircraft carriers in January 2009, its missions having been taken over by the P-3C Orion, P-8 Poseidon, SH-60 Seahawk, and F/A-18E/F Super Hornet. For more a decade after that, some S-3s were flown by Air Test and Evaluation Squadron Thirty (VX-30) at Naval Base Ventura County / NAS Point Mugu, California, for range clearance and surveillance operations at the NAVAIR Point Mugu Range. These final examples in U.S. Navy service were retired in early 2016. The last operational S-3 was used by the National Aeronautics and Space Administration (NASA) at its Glenn Research Center until NASA retired it in mid-2021. Mose retired S-3s were placed into storage while options for their future were investigated. During the 2010s, Lockheed Martin proposed to refurbish them for carrier onboard delivery. The Republic of Korea Navy also had plans to operate revived S-3s for ASW; these plans were cancelled in 2017. | https://en.wikipedia.org/wiki?curid=29475 | 259,824 |
1,269,371 | Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell. Fusion with the plasma membrane to release the core into the host cytoplasm. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins. Assembly of progeny virions starts in cytoplasmic viral factories, producing a spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV). The IMV can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV) host receptors, which mediates endocytosis. Replication follows the DNA strand displacement model. DNA-templated transcription is the method of transcription. The virus exits the host cell by existing in occlusion bodies after cell death and remaining infectious until finding another host. Humans and mammals serve as the natural hosts. Transmission routes are zoonosis and contact. | https://en.wikipedia.org/wiki?curid=1620206 | 1,268,680 |
1,820,348 | In mRNA degradation, ribonuclease E recognizes and cleaves the single-stranded RNA in A- and U-rich regions. The RNase E catalytic domain binds selectively to 5′-monophosphate RNA termini but has a mode of cleavage in the 3′ to 5′ direction. RNase E can identify cleavage sites by a 3′ to 5′ scanning mechanism. The anchor of the RNase E to the 5′-monophosphorylated end of these substrates orients the enzyme for directional cleavages that occur in a processive mode. In the absence of RNA, the S1 subdomain and 5′ sensing site of RNase E are both exposed to the surrounding solvent, allowing RNA to bind readily. In the presence of RNA, target RNA binds to the combined S1 subdomain and 5′ sensor in the open configuration. The RNA is anchored primarily by the binding affinity of the 5′ sensor and oriented by the hydrophobic surface patch on the S1 subdomain. While the S1 subdomain is acting to orient the molecule, the 5′ sensing pocket likely contributes a significant portion of the substrate-binding affinity. These two sites hold the RNA while the fusion 5/S1 subdomain moves as a single complex into the closed configuration. It brings the substrate into proximity to the catalytic site where a hydroxyl group attacks the phosphate backbone by nucleophilic attack reaction. This response is mediated by magnesium ion. When the RNA of interest is cleaved, and the products of the reaction are eventually released as RNase E returns to the open configuration. Besides, RNase E can be self-regulated whereby the mRNA of ribonuclease E serves as a sensor for total cellular RNase E activity and thus limits RNase E activity due to the availability of substrates and changes of growth rate. | https://en.wikipedia.org/wiki?curid=39057774 | 1,819,311 |
1,368,558 | Development of "Overwatch" followed after the cancellation of the ambitious massively multiplayer online role-playing game "Titan", a game that had been in development at Blizzard for seven years since around 2007. "Overwatch" director Jeff Kaplan said that "Titan" was a class-based shooter game, with each class having a core set of abilities that the player would expand upon via a skill tree progression; these skills got more powerful the farther the player progressed, and Kaplan said that it ended up being "very cluttered and confused". Blizzard co-founder Michael Morhaime stated that with "Titan", "We didn't find the fun. We didn't find the passion." even after re-evaluating the project. "Titan" had been canceled internally by May 2013, though this wasn't publicly reported until 2014. The large "Titan" team of 140 members was broken up: 80 were permanently relocated to other divisions in Blizzard, twenty put on loan to other Blizzard projects, and the remaining 40 tasked to come up with a new project within six weeks, otherwise they would be assigned to other groups within Blizzard. Among ideas tossed suggested by this time was "Crossroads", an MMO set in an outpost in space that would have been a crossroads for many different alien species. This game would have featured several different character classes, upwards of fifty, which Kaplan thought would be difficult but remained a core concept of "Crossroads". They also considered developing a tie-in to the "Starcraft" universe, focused around individual characters within that universe. | https://en.wikipedia.org/wiki?curid=55762533 | 1,367,802 |
939,632 | Current bids for new nuclear power plants in China were estimated at between $2800/kW and $3500/kW, as China planned to accelerate its new build program after a pause following the Fukushima disaster. However, more recent reports indicated that China will fall short of its targets. While nuclear power in China has been cheaper than solar and wind power, these are getting cheaper while nuclear power costs are growing. Moreover, third generation plants are expected to be considerably more expensive than earlier plants. Therefore, comparison with other power generation methods is strongly dependent on assumptions about construction timescales and capital financing for nuclear plants. Analysis of the economics of nuclear power must take into account who bears the risks of future uncertainties. To date all operating nuclear power plants were developed by state-owned or regulated utility monopolies where many of the risks associated with political change and regulatory ratcheting were borne by consumers rather than suppliers. Many countries have now liberalized the electricity market where these risks, and the risk of cheap competition from subsidised energy sources emerging before capital costs are recovered, are borne by plant suppliers and operators rather than consumers, which leads to a significantly different evaluation of the risk of investing in new nuclear power plants. Generation III+ reactors are claimed to have a significantly longer design lifetime than their predecessors while using gradual improvements on existing designs that have been used for decades. This might offset higher construction costs to a degree, by giving a longer depreciation lifetime. | https://en.wikipedia.org/wiki?curid=10838742 | 939,131 |
831,570 | Eagleman is currently an adjunct professor at Stanford University, after directing a neuroscience research laboratory for 10 years at Baylor College of Medicine. He serves as the Chief Science Advisor for the Mind Science Foundation, and is the youngest member of the board of directors of the Long Now Foundation. Eagleman is a Guggenheim Fellow, a Fellow of the Institute for Ethics and Emerging Technologies, and a council member on the World Economic Forum's Global Agenda Council on Neuroscience & Behavior. He was voted one of Houston's Most Stylish men, and Italy's "Style" fashion magazine named Eagleman one of the "Brainiest, Brightest Idea Guys" and featured him on the cover. He was awarded the Science Educator Award by the Society for Neuroscience. He has spun off several companies from his research, including BrainCheck, which helps medical professionals assess and diagnose cognitive impairment and dementia, and NeoSensory, which uses sound-to-touch sensory substitution to feed data streams into the brain, as described in his TED talk. | https://en.wikipedia.org/wiki?curid=6058684 | 831,121 |
855,016 | While living at Haverstock Hill, Robert would work six days a week, rising at 5 am, when he would study the sciences and read poetry; he was a firm Tory, but avoided reading political articles in newspapers. He was respected and known as "The Chief", but told a friend that he felt that his reputation would "break under me like an eggshell"; he smoked cigars and he used calomel, a form of mercury chloride; this was commonly mixed with opium. His friend and writer, Francis Roubiliac Conder, said that if Robert was needed on site somewhere he would catch the northbound coach, sometimes sitting on the outside seat without an overcoat on a winter's evening. He did not play his flute at this time. However, Robert would be at home on Sundays attending church and spending time with his wife. Robert and Fanny had no children, but were surrounded by family. Fanny was liked by Robert's friends who would visit, such as Bidder, Gooch, John Joseph Bramah, and the company's solicitor, Charles Parker. She was said to rule "her husband without ever seeming to do so"; to please her he successfully applied to the Herald's College for a coat of arms, paying for it in November 1838, but he never liked it, calling it a "silly picture" just before his death. | https://en.wikipedia.org/wiki?curid=252957 | 854,561 |
1,124,523 | TOA and AOA measurements are also subject to multipath errors, particularly when the direct path from the transmitter to receiver is blocked by an obstacle. Time of arrival measurements are also most accurate when the signal has distinct time-dependent features on the scale of interest—for example, when it is composed of short pulses of known duration—but Fourier transform theory shows that in order to change amplitude or phase on a short time scale, a signal must use a broad bandwidth. For example, to create a pulse of about 1 ns duration, roughly sufficient to identify location to within 0.3 m (1 foot), a bandwidth of roughly 1 GHz is required. In many regions of the radio spectrum, emission over such a broad bandwidth is not allowed by the relevant regulatory authorities, in order to avoid interference with other narrowband users of the spectrum. In the United States, unlicensed transmission is allowed in several bands, such as the 902-928 MHz and 2.4-2.483 GHz Industrial, Scientific, and Medical ISM bands, but high-power transmission cannot extend outside of these bands. However, several jurisdictions now allow ultrawideband transmission over GHz or multi-GHz bandwidths, with constraints on transmitted power to minimize interference with other spectrum users. UWB pulses can be very narrow in time, and often provide accurate estimates of TOA in urban or indoor environments. | https://en.wikipedia.org/wiki?curid=1932188 | 1,123,949 |
1,239,649 | The stoichiometry (measurement of chemical reactants and products) of primary production in the surface ocean plays a crucial role in the cycling of elements in the global ocean. The ratio between the elements carbon (C), nitrogen (N), and phosphorus (P) in exported organic matter expressed in terms of the C:N:P ratio helps determine how much atmospheric carbon is sequestered in the deep ocean with respect to the availability of limiting nutrients. On geologic timescales, the N:P ratio reflects the relative availability of nitrate with respect to phosphate, both of which are externally supplied from the atmosphere via nitrogen fixation and/or continents via river supply and lost by denitrification and burial. On shorter timescales, the average stoichiometry of exported bulk particulate organic matter reflects the elemental stoichiometry of phytoplankton, with additional influences from biological diversity and secondary processing of organic matter by zooplankton and heterotrophic bacteria. In the face of global change, understanding and quantifying the mechanisms that lead to variability in C:N:P ratios are crucial in order to have an accurate projection of future climate change. | https://en.wikipedia.org/wiki?curid=61256010 | 1,238,981 |
91,636 | The aging red blood cell undergoes changes in its plasma membrane, making it susceptible to selective recognition by macrophages and subsequent phagocytosis in the mononuclear phagocyte system (spleen, liver and lymph nodes), thus removing old and defective cells and continually purging the blood. This process is termed eryptosis, red blood cell programmed death. This process normally occurs at the same rate of production by erythropoiesis, balancing the total circulating red blood cell count. Eryptosis is increased in a wide variety of diseases including sepsis, haemolytic uremic syndrome, malaria, sickle cell anemia, beta-thalassemia, glucose-6-phosphate dehydrogenase deficiency, phosphate depletion, iron deficiency and Wilson's disease. Eryptosis can be elicited by osmotic shock, oxidative stress, and energy depletion, as well as by a wide variety of endogenous mediators and xenobiotics. Excessive eryptosis is observed in red blood cells lacking the cGMP-dependent protein kinase type I or the AMP-activated protein kinase AMPK. Inhibitors of eryptosis include erythropoietin, nitric oxide, catecholamines and high concentrations of urea. | https://en.wikipedia.org/wiki?curid=67158 | 91,596 |
382,820 | Surveying instruments have characteristics that make them suitable for certain uses. Theodolites and levels are often used by constructors rather than surveyors in first world countries. The constructor can perform simple survey tasks using a relatively cheap instrument. Total stations are workhorses for many professional surveyors because they are versatile and reliable in all conditions. The productivity improvements from a GPS on large scale surveys makes them popular for major infrastructure or data gathering projects. One-person robotic-guided total stations allow surveyors to measure without extra workers to aim the telescope or record data. A fast but expensive way to measure large areas is with a helicopter, using a GPS to record the location of the helicopter and a laser scanner to measure the ground. To increase precision, surveyors place beacons on the ground (about apart). This method reaches precisions between 5–40 cm (depending on flight height). | https://en.wikipedia.org/wiki?curid=60891 | 382,625 |
1,791,189 | To create the mutant, three genes were inactivated that green sulfur bacteria acquired late in their evolution. In this way it was possible to go backward in evolutionary time to an intermediate state with much less variable and better ordered chlorosome organelles than the wild-type. The chlorosomes were isolated from the mutant and the wild-type forms of the bacteria. Cryo-electron microscopy was used to take pictures of the chlorosomes. The images reveal that the chlorophyll molecules inside chlorosomes have a nanotube shape. The team then used MAS NMR spectroscopy to resolve the microscopic arrangement of chlorophyll inside the chlorosome. With distance constraints and DFT ring current analyses the organization was found to consist of unique syn-anti monomer stacking. The combination of NMR, cryo-electron microscopy and modeling enabled the scientists to determine that the chlorophyll molecules in green sulfur bacteria are arranged in helices. In the mutant bacteria, the chlorophyll molecules are positioned at a nearly 90-degree angle in relation to the long axis of the nanotubes, whereas the angle is less steep in the wild-type organism. The structural framework can accommodate disorder to improve the biological light harvesting function, which implies that a less ordered structure has a better performance. | https://en.wikipedia.org/wiki?curid=4487041 | 1,790,182 |
368,451 | The MiG-29K project was initiated in the late 1970s when the Soviet Navy developed a requirement for a supersonic carrier-based fighter. As a first step to meet this requirement, the Mikoyan design bureau designed a "proof of concept" version of the MiG-29 fitted with a stronger undercarriage and a reinforced tail section with an arrestor hook, the MiG-29KVP ("Korotkii Vzlet i Posadka", or "short take off and landing"). The KVP first flew on 21 August 1982, and was subject to extensive trials which demonstrated it could safely operate from a ski-jump, but ideally a production aircraft needed more power and greater wing area. It was decided to base the definitive naval version on the advanced MiG-29M ("izdeliye" "Product" 9.15) that was already under development, further modified with new undercarriage and folding wings of greater area, with the new model designated the MiG-29K ("Korabelniy" – "ship based") or Project 9–31. The MiG-29K differed considerably from the MiG-29 production model, featuring a new multi-function radar, dubbed Zhuk; a cockpit with monochrome display and use of the HOTAS (hands-on-throttle-and-stick) principle; the RVV-AE air-to-air active homing missiles; antiship and antiradar missiles; as well as air-to-ground precision-guided weapons. To protect the engine from foreign object damage (FOD), the engine inlets were fitted with retractable grills for air flow, rather than metal doors and leading-edge extension auxiliary intake louvres used by land-based MiG-29s. | https://en.wikipedia.org/wiki?curid=3687116 | 368,258 |
502,665 | Forensic engineering has been defined as ""the investigation of failures - ranging from serviceability to catastrophic - which may lead to legal activity, including both civil and criminal"." It includes the investigation of materials, products, structures or components that fail or do not operate or function as intended, causing personal injury, damage to property or economic loss. The consequences of failure may give rise to action under either criminal or civil law including but not limited to health and safety legislation, the laws of contract and/or product liability and the laws of tort. The field also deals with retracing processes and procedures leading to accidents in operation of vehicles or machinery. Generally, the purpose of a forensic engineering investigation is to locate cause or causes of failure with a view to improve performance or life of a component, or to assist a court in determining the facts of an accident. It can also involve investigation of intellectual property claims, especially patents. In the US, forensic engineers require a professional engineering license from each state. | https://en.wikipedia.org/wiki?curid=69817 | 502,407 |
864,528 | The intimate relationships that necessarily existed between metrology and geodesy explain that the International Association of Geodesy, founded to combine and use the geodetic works of different countries, in order to reach a new and more exact determination of the shape and dimensions of the Globe, gave birth to the idea of reforming the foundations of the metric system, while expanding it and making it international. Not, as it was mistakenly assumed for a certain time, that the Association had the unscientific thought of modifying the length of the metre, in order to conform exactly to its historical definition according to the new values that would be found for the terrestrial meridian. But, busy combining the arcs measured in the different countries and connecting the neighbouring triangulations, geodesists encountered, as one of the main difficulties, the unfortunate uncertainty which reigned over the equations of the units of length used. Adolphe Hirsch, General Baeyer and Colonel Ibáñez decided, in order to make all the standards comparable, to propose to the Association to choose the metre for geodetic unit, and to create an international prototype metre differing as little as possible from the "mètre des Archives." | https://en.wikipedia.org/wiki?curid=28200487 | 864,068 |
453,877 | Before the Enlightenment, virtually all Jews believed that the Torah was dictated to Moses by God. Since many parts of the Torah, specifically the laws and commandments, are written in unspecific terms, they also believed that Moses received an interpretation of the Torah that was transmitted through the generations in oral form till it was finally put in writing in the Mishnah and later, in greater detail, the Talmud. After the Enlightenment, many Jews began to participate in wider European society, where they engaged in study related to critical methods of textual analysis, including both lower and higher criticism, the modern historical method, hermeneutics, and fields relevant to Bible study such as Near Eastern archaeology and linguistics. In time the documentary hypothesis emerged from these studies. The documentary hypothesis holds that the Torah was not written by Moses, but was simply written by different people who lived during different periods of Israelite history. Some Jews adapted the findings of these disciplines. Consequently, biblical study primarily focused on the intentions of these people, and the circumstances in which they lived. This type of study depends on evidence external to the text, especially archaeological evidence and comparative literature. | https://en.wikipedia.org/wiki?curid=142703 | 453,656 |
1,157,443 | The species is the largest member in its genus and specimens may have a height (from tip of dorsal to tip of anal fin) of as much as . Its natural base color is silver but with three brownish/red vertical stripes and red striations into the fins. The species may show red spotting and a blueish green dorsal overcast when mature and when aroused exhibits a black operculum spot. Characteristic of this species is an acute incision or notch above the nares (supraorbital indention). All true Orinoco altum specimens show this trait. The true wildcaught Orinoco altum is very difficult to breed in captivity. Most altum angelfish are more frequently found in the well oxygenated, extremely soft waters of Upper and Middle Orinoco tributaries shed from the Guiana Shield Highlands, preferring a pH range between 4.5 and 5.8. These are very transparent blackwaters with almost nil conductivity. Temperature range in these waters is between . They are also found in the Atabapo River and Inirida River floodplain, down the Casiquiare and Guainía floodplain where the Rio Negro is born, before entering Brazilian territory. Unlike "P. scalare" which prefer to spawn on the submerged leaves of plants and trees in the flooded rainforest, "P. altum" prefers to spawn on submerged roots and tree branches in a moderate water current. This species is recommended for intermediate to advanced aquarists due to the detailed maintenance it requires for proper health. | https://en.wikipedia.org/wiki?curid=729247 | 1,156,830 |
737,360 | Wildlife in cities are more susceptible to suffering ill effects from exposure to toxicants (such as heavy metals and pesticides). In China, fish that were exposed to industrial wastewater had poorer body condition; being exposed to toxicants can increase susceptibility to infection. Humans have the potential to induce patchy food distribution, which can promote animal aggregation by attracting a high number of animals to common food sources; “this aggregation may increase the spread of parasites transmitted through close contact; parasite deposition on soil, water, or artificial feeders; and stress through inter‐ and intraspecific competition.” The results of a study performed by Maureen Murray (et al.), in which a phylogenetic meta-analysis of 516 comparisons of overall wildlife condition reported in 106 studies was performed, confirmed these results; “our meta‐analysis suggests an overall negative relationship between urbanization and wildlife health, mainly driven by considerably higher toxicant loads and greater parasite abundance, greater parasite diversity, and/or greater likelihood of infection by parasites transmitted through close contact.” | https://en.wikipedia.org/wiki?curid=295670 | 736,971 |
1,086,184 | Upon its move to London in 1877 the Institution rented premises at No. 10 Victoria Chambers, where it remained for 20 years. In 1895 the Institution bought a plot of land at Storey's Gate, on the eastern end of Birdcage Walk, for £9,500. Architect Basil Slade looked to the newly-completed Admiralty buildings facing the site for inspiration. The building was designed in the Queen Anne, 'streaky bacon', style in red brick and Portland stone. Inside, there were several features that were state of the art for the time, including a telephone, a 54-inch fan in the lecture theatre for driving air into the building, an electric lift from the Otis Elevator Company, and a Synchronome master-clock, which controlled all house timepieces. In 1933 architect James Miller, who also designed the neighbouring Institution of Civil Engineers, remodelled the building, expanding the library and introducing electric lighting. | https://en.wikipedia.org/wiki?curid=1404820 | 1,085,626 |
555,397 | Born the son of Hall Plumer and Louisa Alice Plumer (née Turnley) and educated at Eton College and the Royal Military College, Sandhurst, Plumer was commissioned as a lieutenant into the 65th Regiment of Foot on 11 September 1876. He joined his regiment in India and became adjutant of his battalion on 29 April 1879. Promoted to captain on 29 May 1882, he accompanied his battalion to the Sudan in 1884 as part of the Nile Expedition. Plumer was present at the battle of El Teb in February 1884 and the battle of Tamai in March 1884, and was mentioned in Despatches. He spent from 1886 to 1887 attending the Staff College, Camberley, before being appointed Deputy-Assistant Adjutant-General in Jersey on 7 May 1890. He was promoted to major on 22 January 1893 and posted to the 2nd Battalion the York and Lancaster Regiment before being appointed assistant military secretary to the General Officer Commanding Cape Colony in December 1895. He went to Southern Rhodesia in 1896 to disarm the local police force following the Jameson Raid and then later that year returned there to command the Matabele Relief Force during the Second Matabele War. He became deputy assistant adjutant-general at Aldershot with promotion to brevet lieutenant colonel on 8 May 1897. | https://en.wikipedia.org/wiki?curid=1126070 | 555,108 |
1,295,040 | The Mathnasium approach first revolves around an assessment to determine what a student does and does not know. Next, a personalized and prescriptive learning program is made. Each student follows the program with the help of specially trained Mathnasium math instructors who provide instruction and encouragement. For proof of progress, Mathnasium relies on its assessments, as well as students' report cards, independent tests, and parent testimony to measure the speed and magnitude of improvement in math skills, numerical thinking, and attitude. Mathnasium separates levels of instruction into early education, elementary school, middle school, and high school. Students advance to a new level of study when they demonstrate mastery of the subject through completing mastery checks, where students have to answer a worksheet of problems correctly without help from instructors. Instructors work face-to-face with each student, and the ratio of instructors to students is typically up to 1:4. Students are encouraged to bring in homework and get help on it as well. To encourage students, work they complete counts towards prizes, and they also can have chances to be entered into drawings for bigger prizes, such as gift cards. Instructors also grade student work and make sure that each worksheet is correct, which reinforces the Mathnasium Method™ of focusing on getting the process correct. | https://en.wikipedia.org/wiki?curid=27742079 | 1,294,329 |
1,286,502 | High stiffness and excellent chemical stability makes BNNTs ideal material for reinforcement in polymers, ceramics and metals. For instance, buckypaper-based BNNT/epoxy composites and polyurethane-modified buckypaper composites have been successfully developed. These composite materials exhibit Young’s moduli over twice the value for neat epoxy and 20 times the value for unimpregnated buckypaper. BNNTs are also one of the most promising classes of material for reinforcing aluminum-based structures. The low reactivity of BNNTs facilitates the integration of this material into an aluminum matrix where CNTs fail due to the reaction between the carbon and the aluminum which forms the undesired AlC phase at the interface. BNNTs also exhibit much higher oxidation temperature (~950 °C) than the melting point of aluminum (660 °C), which enables the homogenous dispersion of BNNTs directly into the aluminum melt. Since BNNTs retain their mechanical properties at high temperatures while having a very low density, the development of new temperature-resistant lightweight MMC is achievable. BNNTs also exhibit good thermal conductivity. This renders them useful for applications in nanoelectronics where heat dissipation is critical. This also makes BNNTs multifunctional as it not only improves the stiffness of composites but also yields high thermal conductivity along with high transparency. The combination of high stiffness and high transparency is already exploited in the development of BNNT-reinforced glass composites. Other intrinsic properties of BNNTs such as good radiation shielding ability, high electrical resistance and excellent piezoelectric properties are likely to promote interest for integrating them in new applications. | https://en.wikipedia.org/wiki?curid=48540155 | 1,285,801 |
403,792 | The decade that followed the 1989 repurchase was a time of significant advancements for Gulfstream. The company signed a five-year contract with NetJets in 1994. It completed the Gulfstream V Integration Test Facility and rolled out the GV – the first ultra-long range business jet – in 1995. The opening of a $16 million Savannah service center with of hangar space followed in 1996. In 1997, Gulfstream began the simultaneous manufacture of two aircraft models – the GIV-SP and the GV. Within a few months of the GV's first delivery in June 1997, it set nearly 40 city-pair and/or speed and distance records, and its development team was awarded the 1997 Robert J. Collier Trophy, the highest honor in aeronautics or astronautics in North America. In 1998, Gulfstream purchased K-C Aviation from Kimberly-Clark Corp. for $250 million, which had operations in Dallas, Appleton, Wisconsin, and Westfield, Massachusetts. | https://en.wikipedia.org/wiki?curid=511793 | 403,592 |
624,901 | The various geyser basins are located where rainwater and snowmelt can percolate into the ground, get indirectly superheated by the underlying Yellowstone hotspot, and then erupt at the surface as geysers, hot springs, and fumaroles. Thus flat-bottomed valleys between ancient lava flows and glacial moraines are where most of the large geothermal areas are located. Smaller geothermal areas can be found where fault lines reach the surface, in places along the circular fracture zone around the caldera, and at the base of slopes that collect excess groundwater. Due to the Yellowstone Plateau's high elevation the average boiling temperature at Yellowstone's geyser basins is 199 °F (93 °C). When properly confined and close to the surface it can periodically release some of the built-up pressure in eruptions of hot water and steam that can reach up to 390 feet (120 m) into the air (see Steamboat Geyser, the world's tallest geyser). Water erupting from Yellowstone's geysers is superheated above that boiling point to an average of 204 °F (95.5 °C) as it leaves the vent. The water cools significantly while airborne and is no longer scalding hot by the time it strikes the ground, nearby boardwalks, or even spectators. Because of the high temperatures of the water in the features it is important that spectators remain on the boardwalks and designated trails. Several deaths have occurred in the park as a result of falls into hot springs. | https://en.wikipedia.org/wiki?curid=245174 | 624,568 |
698,296 | Various astronomers, especially those who had access to more precise observations, were skeptical of the geocentric Ptolemaic model and proposed alternatives, including the heliocentric theory (now known to be correct) where the planets and the Earth orbit the Sun. Many proposals did not diffuse outside the local culture, or did not become locally dominant. Aristarchus of Samos had speculated about heliocentrism in Ancient Greece; in Al-Andalus, Arzachel proposed that Mercury orbits the Sun, and heliocentric astronomers worked in the Maragha school in Persia. Kerala-based astronomer Nilakantha Somayaji proposed a geoheliocentric systems, in which the planets circled the Sun while the Sun and Moon and stars orbiting the Earth. Polish astronomer Nicolaus Copernicus developed a system called Copernican heliocentrism, in which the planets and the Earth orbit the Sun, and the Moon orbits the Earth. Though the by-then-late Copernicus' theory was known to Danish astronomer Tycho Brahe, he did not accept it, and proposed his own geoheliocentric Tychonic system. Brahe undertook a substantial series of more accurate observations. German natural philosopher Johannes Kepler at first worked to combine Copernican system with Platonic solids in line with his interpretation of Christianity and an ancient musical resonance theory known as "Musica universalis". After becoming an assistant for Brahe, Kepler inherited the observations and was directed to mathematically analyze the orbit of Mars. After many failed attempts, he eventually made the groundbreaking discovery that the planets moved around the Sun in ellipses. He formulated and published what are now known as Kepler's laws of planetary motion from 1609 to 1615. This became the dominant model among astronomers, though as with celestial sphere models, the physical mechanism by which this motion occurred was somewhat mysterious and theories abounded. | https://en.wikipedia.org/wiki?curid=19327051 | 697,932 |
1,018,135 | The first of these designs that the He 277 was pitted against, mostly to determine the "most producible" bomber that could also be license-built, given Germany's limited aircraft production capacity to arm the Luftwaffe with, and partially to determine the best long-range bomber design to fulfill the needs of the spring 1942-issued "Amerikabomber" program documents, the Messerschmitt Me 264 ended up being the first design to challenge the He 277's chance for production. The Me 264 was a purpose-built long-range bomber, using a tricycle landing gear configuration from the start. The Me 264 prototypes were already flying their test programs with power of exactly the same choice that Heinkel had asked for on November 17, 1938, for the He 177 V3 and V4 prototypes: with four Junkers Jumo 211 engines as early as late December 1942 – a full year after Nazi Germany had declared war on the United States, five months after the Eighth Air Force had begun flying bomber missions against Nazi-occupied France, and two months before the RLM's earliest-known mention of any recorded approval for the He 277 design itself — the later fitment of a quartet of the BMW 801 radials to each example of the trio of Me 264 prototypes also potentially challenged the availability of the same engine design that the He 277 was meant to use, had the Me 264 gone into production with them. | https://en.wikipedia.org/wiki?curid=455378 | 1,017,609 |
1,725,889 | As more research is performed on, further developments will be made that will increase the viability and usability of cortical implants. Decreasing the size of the implants would help with keeping procedures less complicated and reducing the bulk. The longevity of these devices is also being considered as developments are made. The goal with the development of new implants is "to avoid the hydrolytic, oxidative and enzymatic degradation due to the harsh environment of the human body or at least to slow it down to a minimum which enables the interface to work over a long time period, before it finally has to be exchanged." With extended operational lifetimes, fewer operations would need to be performed for maintenance, allowing for The amount of polymers that are now able to be used for neural implants has increased, allowing for a greater diversity of devices. As technology improves, researchers are able to more densely place electrodes into arrays, permitting high selectivity. Other areas of investigation are the battery packs that power these devices. Effort has been made to try and reduce the overall size and bulkiness of these packs to make them less obtrusive for the patient. Reducing the amount of power each implant requires is also of interest, as this will reduce the amount of heat the implant makes, therefore reducing the risk of damage to the surrounding tissues. | https://en.wikipedia.org/wiki?curid=49706798 | 1,724,918 |
1,081,321 | The J-2X was intended to be based on the J-2 used on the S-II and S-IVB stages of the Saturn rockets used during the Apollo program, but as required thrust for the Ares I increased due to weight problems it became a clean-sheet design. It entered development in 2007 as part of the now-cancelled Constellation program. Originally planned for use on the upper stages of the Ares I and Ares V rockets, the J-2X was later intended for use in the Earth Departure Stage of the Block 2 Space Launch System, the successor to the Constellation program. The engine is intended to be more efficient and simpler to build than its J-2 ancestor, and cost less than the RS-25 engine. Differences in the new engine include the removal of beryllium, a centrifugal turbo pump versus the axial turbo pump of the J-2, different chamber and nozzle expansion ratios, a channel-walled combustion chamber versus the tube-welded chamber of the J-2, a redesign of all the electronics, a gas generator and supersonic main injector based on the RS-68, and the use of 21st-century joining techniques. | https://en.wikipedia.org/wiki?curid=5846760 | 1,080,765 |
1,184,892 | Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal loss over time, which can be expressed as a differential equation. It is a widely explored treatment option for many central nervous system (CNS) disorders including neurodegenerative diseases, stroke, traumatic brain injury, spinal cord injury, and acute management of neurotoxin consumption (i.e. methamphetamine overdoses). Neuroprotection aims to prevent or slow disease progression and secondary injuries by halting or at least slowing the loss of neurons. Despite differences in symptoms or injuries associated with CNS disorders, many of the mechanisms behind neurodegeneration are the same. Common mechanisms of neuronal injury include decreased delivery of oxygen and glucose to the brain, energy failure, increased levels in oxidative stress, mitochondrial dysfunction, excitotoxicity, inflammatory changes, iron accumulation, and protein aggregation. Of these mechanisms, neuroprotective treatments often target oxidative stress and excitotoxicity—both of which are highly associated with CNS disorders. Not only can oxidative stress and excitotoxicity trigger neuron cell death but when combined they have synergistic effects that cause even more degradation than on their own. Thus limiting excitotoxicity and oxidative stress is a very important aspect of neuroprotection. Common neuroprotective treatments are glutamate antagonists and antioxidants, which aim to limit excitotoxicity and oxidative stress respectively. | https://en.wikipedia.org/wiki?curid=2597506 | 1,184,264 |
408,594 | The Andromeda Galaxy is approaching the Milky Way at about as indicated by blueshift. However, the lateral speed (measured as proper motion) is very difficult to measure with sufficient precision to draw reasonable conclusions. Until 2012, it was not known whether the possible collision was definitely going to happen or not. Researchers then used the Hubble Space Telescope to measure the positions of stars in Andromeda in 2002 and 2010, relative to hundreds of distant background galaxies. By averaging over thousands of stars, they were able to obtain the average proper motion with sub-pixel accuracy. The conclusion was that Andromeda is moving southeast in the sky at less than 0.1 milliarc-seconds per year, corresponding to a speed relative to the Sun of less than 200 km/s towards the south and towards the east. Taking also into account the Sun's motion, Andromeda's tangential or sideways velocity with respect to the Milky Way was found to be much smaller than the speed of approach (consistent with zero given the uncertainty) and therefore it will eventually merge with the Milky Way in around 5 billion years. | https://en.wikipedia.org/wiki?curid=7901784 | 408,393 |
742,724 | Peroxisomes can be derived from the smooth endoplasmic reticulum under certain experimental conditions and replicate by membrane growth and division out of pre-existing organelles. Peroxisome matrix proteins are translated in the cytoplasm prior to import. Specific amino acid sequences (PTS or peroxisomal targeting signal) at the "C-terminus" (PTS1) or "N-terminus" (PTS2) of peroxisomal matrix proteins signals them to be imported into the organelle by a targeting factor. There are currently 36 known proteins involved in peroxisome biogenesis and maintenance, called peroxins, which participate in the process of peroxisome assembly in different organisms. In mammalian cells there are 13 characterized peroxins. In contrast to protein import into the endoplasmic reticulum (ER) or mitochondria, proteins do not need to be unfolded to be imported into the peroxisome lumen. The matrix protein import receptors, the peroxins PEX5 and PEX7, accompany their cargoes (containing a PTS1 or a PTS2 amino acid sequence, respectively) all the way to the peroxisome where they release the cargo into the peroxisomal matrix and then return to the cytosol – a step named "recycling". A special way of peroxisomal protein targeting is called piggy backing. Proteins that are transported by this unique method do not have a canonical PTS, but rather bind on a PTS protein to be transported as a complex. A model describing the import cycle is referred to as the "extended shuttle mechanism". There is now evidence that ATP hydrolysis is required for the recycling of receptors to the cytosol. Also, ubiquitination is crucial for the export of PEX5 from the peroxisome to the cytosol. The biogenesis of the peroxisomal membrane and the insertion of peroxisomal membrane proteins (PMPs) requires the peroxins PEX19, PEX3, and PEX16. PEX19 is a PMP receptor and chaperone, which binds the PMPs and routes them to the peroxisomal membrane, where it interacts with PEX3, a peroxisomal integral membrane protein. PMPs are then inserted into the peroxisomal membrane. | https://en.wikipedia.org/wiki?curid=24062 | 742,330 |
1,318,729 | After the June 2015 Charleston church shooting, radio commentators Colin McEnroe and Ray Hardman questioned whether the preservation of the college's name was an inappropriate legacy of white supremacy. The events, which instigated student protests and alumni petitions in the same year, caused administrators to consider renaming the college. In their petition students argued that—while Calhoun was respected in the 19th century as an "extraordinary American statesman"—he was "one of the most prolific defenders of slavery and white supremacy" in the history of the United States. In August 2015 Yale President Peter Salovey addressed the Freshman Class of 2019 in which he responded to the racial tensions but explained why the college would not be renamed. He described Calhoun as "a notable political theorist, a vice president to two different U.S. presidents, a secretary of war and of state, and a congressman and senator representing South Carolina." He acknowledged that Calhoun also "believed that the highest forms of civilization depend on involuntary servitude. Not only that, but he also believed that the races he thought to be inferior, black people in particular, ought to be subjected to it for the sake of their own best interests." | https://en.wikipedia.org/wiki?curid=1300577 | 1,318,004 |
742,222 | Different hemorrhagic fever viruses act on the body in different ways, resulting in different symptoms. In most VHFs, it is likely that several mechanisms contribute to symptoms, including liver damage, disseminated intravascular coagulation (DIC), and bone marrow dysfunction. In DIC, small blood clots form in blood vessels throughout the body, removing platelets necessary for clotting from the bloodstream and reducing clotting ability. DIC is thought to cause bleeding in Rift Valley, Marburg, and Ebola fevers. For filoviral hemorrhagic fevers, there are four general mechanisms of pathogenesis. The first mechanism is dissemination of virus due to suppressed responses by macrophages and dendritic cell (antigen presenting cells). The second mechanism is prevention of antigen specific immune response. The third mechanism is apoptosis of lymphocytes. The fourth mechanism is when infected macrophages interact with toxic cytokines, leading to diapedesis and coagulation deficiency. From the vascular perspective, the virus will infect vascular endothelial cells, leading to the reorganization of the VE-cadherin catenin complex (a protein important in cell adhesion). This reorganization creates intercellular gaps in endothelial cells. The gaps lead to increased endothelial permeability and allow blood to escape from the vascular circulatory system. | https://en.wikipedia.org/wiki?curid=1719309 | 741,830 |
305,213 | In the 1960s and 1970s the new social forces, introduced, the social democrats argued, by their 'mixed economy' and their many reforms of capitalism, began to change the political landscape in the western world. The long postwar boom and the rapid expansion of higher education produced, as well as rising living standards for the industrial working class, a mass university-educated white collar workforce, nevertheless began to break down the old socialist-versus-conservative polarity of European politics. This new white-collar workforce, some claimed, was less interested in traditional socialist policies such as state ownership and more interested expanded personal freedom and liberal social policies. The proportion of women in the paid workforce increased and many supported the struggle for equal pay, which, some argued, changed both the composition and the political outlook of the working class. Some socialist parties reacted more flexibly and successfully to these changes than others, but eventually the leaderships of all social democracies in Europe moved to an explicitly pro-capitalist stance. Symbolically in the UK, the socialist clause, Clause four, was removed from the Labour Party constitution, in 1995. A similar change took place in the German SDP. | https://en.wikipedia.org/wiki?curid=47246185 | 305,051 |
1,642,150 | As a practical example, an efficient image inpainting method for color images via the CSC model is shown. Consider the three-channel dictionary formula_200, where formula_201 denotes the formula_118-th atom at channel formula_104, represents signal formula_5 by a single cross-channel sparse representation formula_6, with stripes denoted as formula_206. Given an observation formula_207, where randomly chosen channels at unknown pixel locations are fixed to zero, in a similar way to impulse noise, the problem is formulated as: formula_208 By means of ADMM, the cost function is decoupled into simpler sub-problems, allowing an efficient formula_6 estimation. Algorithm 2 describes the procedure, where formula_210 is the DFT representation of formula_211, the convolutional matrix for the term formula_212. Likewise, formula_213 and formula_214 correspond to the DFT representations of formula_215 and formula_216, respectively, formula_217 corresponds to the Soft-thresholding function with argument formula_218, and the formula_219 norm is defined as the formula_33 norm along the channel dimension formula_104 followed by the formula_144 norm along the spatial dimension formula_118. The reader is referred to (, Section II) for details on the ADMM implementation and the dictionary learning procedure. | https://en.wikipedia.org/wiki?curid=59448183 | 1,641,223 |
930,620 | Since the 1970s and 1980s, several scholars have attempted a systematic re-evaluation of the inscriptional and papyrological evidence (Smith 1972, Teodorsson 1974, 1977, 1978; Gignac 1976; Threatte 1980, summary in Horrocks 1999). According to their results, many of the relevant phonological changes can be dated fairly early, reaching well into the classical period, and the period of the Koiné can be characterised as one of very rapid phonological change. Many of the changes in vowel quality are now dated to some time between the 5th and the 1st centuries BC, while those in the consonants are assumed to have been completed by the 4th century AD. However, there is still considerable debate over precise dating, and it is still not clear to what degree, and for how long, different pronunciation systems would have persisted side by side within the Greek speech community. The resulting majority view today is that a phonological system roughly along Erasmian lines can still be assumed to have been valid for the period of classical Attic literature, but biblical and other post-classical Koine Greek is likely to have been spoken with a pronunciation that already approached that of Modern Greek in many crucial respects. | https://en.wikipedia.org/wiki?curid=3110015 | 930,129 |
441,970 | The wavelengths at which azobenzene isomerization occurs depends on the particular structure of each azo molecule, but they are typically grouped into three classes: the azobenzene-type molecules, the aminoazobenzenes, and the pseudo-stilbenes. These azos are yellow, orange, and red, respectively, owing to the subtle differences in their electronic absorption spectra. The compounds similar to the unsubstituted azobenzene exhibit a low-intensity n-π* absorption in the visible region, and a much higher intensity π-π* absorption in the ultraviolet. Azos that are ortho- or para-substituted with electron-donating groups (such as aminos), are classified as aminoazobenzenes, and tend to closely spaced n-π* and π-π* bands in the visible. The pseudo-stilbene class is characterized by substituting the 4 and 4' positions of the two azo rings with electron-donating and electron-withdrawing groups (that is, the two opposite ends of the aromatic system are functionalized). The addition of this push-pull configuration results in a strongly asymmetric electron distribution, which modifies a host of optical properties. In particular, it shifts the absorption spectra of the "trans" and the "cis" isomers, so that they effectively overlap. Thus, for these compounds a single wavelength of light in the visible region will induce both the forward and reverse isomerization. Under illumination, these molecules cycle between the two isomeric states. | https://en.wikipedia.org/wiki?curid=1107528 | 441,755 |
24,342 | Sixth edition was released on June 23, 2012. Changes to this edition included the adoption of an optional Psychic Power card system similar to that of the game's sister product "Warhammer Fantasy Battle" as well as the inclusion of full rules for flying vehicles and monsters and a major reworking of the manner in which damage is resolved against vehicles. It also included expanded rules for greater interaction with scenery and more dynamic close-combat. In addition to updating existing rules and adding new ones, 6th Edition introduced several other large changes: the Alliance system, in which players can bring units from other armies to work with their own, with varying levels of trust; the choice to take one fortification as part of your force; and Warlord traits, which will allow a player's Commander to gain a categorically randomised trait that can aid their forces in different situations. Replacing the "Assault on Black Reach" box set was the "Dark Vengeance" box set which included Dark Angels and Chaos Space Marine models. Some of the early release box sets of Dark Vengeance contained a limited edition Interrogator-Chaplain for the Dark Angels. | https://en.wikipedia.org/wiki?curid=89633 | 24,333 |
1,213,327 | On 5 May 1998, a fire broke out onboard while off the Western Australia coast. The fire was caused by the rupture of a flexible fuel line (one of a number used to replace rigid hoses) on cylinder number nine, starboard engine. This sprayed diesel fuel onto a hot indicator cock, which ignited a spray fire, resulting in the deaths of four crew. Following the fire, the Australian Government and the RAN began a major investigation known as the "Westralia Board of Inquiry". The enquiry found that the RAN and the contractor Australian Defence Industries (ADI) did not critically examine their course of action and that key personnel in both the RAN and the contractor were insufficiently trained and qualified. The inquiry also found that the hoses were not properly designed and were unfit for the intended purpose. In 2005, ADI was fined $75,000 for failing to provide a safe workplace. Seven sailors who were severely traumatised by the fire have also sued ADI and subcontractor Jetrock. In August 2006, the Australian Government decided to accept liability after it reached settlement with the ADI and Jetrock. The seven sailors stand to receive compensation totalling up to $10 million. | https://en.wikipedia.org/wiki?curid=5606945 | 1,212,675 |
1,296,238 | As the aircraft climbed through 30 minutes into the flight, according to the subsequent mishap investigation report "the aircraft encountered turbulence and morphed into an unexpected, persistent, high dihedral configuration. As a result of the persistent high dihedral, the aircraft became unstable in a very divergent pitch mode in which the airspeed excursions from the nominal flight speed about doubled every cycle of the oscillation. The over-speed condition was exacerbated when the pilot turned off the airspeed hold loop instead of executing the correct emergency procedure and increasing the airspeed hold loop gain. The aircraft’s design airspeed was subsequently exceeded and the resulting high dynamic pressures caused the wing leading edge secondary structure on the outer wing panels to fail and the solar cells and skin on the upper surface of the wing to rip off. The aircraft impacted the ocean within the confines of the Pacific Missile Range Facility test range and was destroyed. Most of the vehicle structure was recovered except the hydrogen–air fuel cell pod and two of the ten motors, which sank into the ocean." | https://en.wikipedia.org/wiki?curid=22078663 | 1,295,527 |
777,339 | Economists believe that incentives and costs play a pervasive role in shaping decision making. An immediate example of this is the consumer theory of individual demand, which isolates how prices (as costs) and income affect quantity demanded. Modern mainstream economics has foundations in neoclassical economics, which began to develop in the late 19th century. Mainstream economics also acknowledges the existence of market failure and insights from Keynesian economics, most contemporaneously in the macroeconomic new neoclassical synthesis. It uses models of economic growth for analyzing long-run variables affecting national income. It employs game theory for modeling market or non-market behavior. Some important insights on collective behavior (for example, emergence of organizations) have been incorporated through the new institutional economics. A definition that captures much of modern economics is that of Lionel Robbins in a 1932 essay: "the science which studies human behaviour as a relationship between ends and scarce means which have alternative uses." Scarcity means that available resources are insufficient to satisfy all wants and needs. Absent scarcity and alternative uses of available resources, there is no economic problem. The subject thus defined involves the study of choice, as affected by incentives and resources. | https://en.wikipedia.org/wiki?curid=8693555 | 776,923 |
190,400 | Iñupiat people on the North Slope of Alaska had mined oil-saturated peat for possibly thousands of years, using it as fuel for heat and light. Whalers who stayed at Point Barrow saw the substance the Iñupiat called pitch and recognized it as petroleum. Charles Brower, a whaler who settled at Barrow and operated trading posts along the Arctic coast, directed geologist Alfred Hulse Brooks to oil seepages at Cape Simpson and Fish Creek in the far north of Alaska, east of the village of Barrow. Brooks' report confirmed the observations of Thomas Simpson, an officer of the Hudson's Bay Company who first observed the seepages in 1836. Similar seepages were found at the Canning River in 1919 by Ernest de Koven Leffingwell. Following the First World War, as the United States Navy converted its ships from coal to fuel oil, a stable supply of oil became important to the U.S. government. Accordingly, President Warren G. Harding established by executive order a series of Naval Petroleum Reserves (NPR-1 through -4) across the United States. These reserves were areas thought to be rich in oil and set aside for future drilling by the U.S. Navy. Naval Petroleum Reserve No. 4 was sited in Alaska's far north, just south of Barrow, and encompassed . Other Naval Petroleum Reserves were embroiled in controversy over government corruption in the Teapot Dome Scandal. | https://en.wikipedia.org/wiki?curid=197732 | 190,303 |
1,397,631 | As described in Chapters 6-10 of the concept study's Final Report, "Lynx" is designed as an X-ray observatory with a grazing incidence X-ray telescope and detectors that record the position, energy, and arrival time of individual X-ray photons. Post-facto aspect reconstruction leads to modest requirements on pointing precision and stability, while enabling accurate sky locations for detected photons. The design of the "Lynx" spacecraft draws heavily on heritage from the "Chandra X-ray Observatory", with few moving parts and high technology readiness level elements. "Lynx" will operate in a halo orbit around Sun-Earth L2, enabling high observing efficiency in a stable environment. Its maneuvers and operational procedures on-orbit are nearly identical to "Chandra"'s, and similar design approaches promote longevity. Without in-space servicing, "Lynx" will carry enough consumables to enable continuous operation for at least twenty years. The spacecraft and payload elements are, however, designed to be serviceable, potentially enabling an even longer lifetime. | https://en.wikipedia.org/wiki?curid=55589664 | 1,396,858 |
1,232,884 | The cell cycle begins with interphase when the DNA replicates, the cell grows and prepares to enter mitosis. Mitosis includes four phases, prophase, metaphase, anaphase, and telophase. Prophase is the initial phase when spindle fibers appear that function to move the chromosomes toward opposite poles. This spindle apparatus consists of microtubules, microfilaments and a complex network of various proteins. During metaphase, the chromosomes line up using the spindle apparatus in the middle of the cell along the equatorial plate. The chromosomes move to opposite poles during anaphase and remain attached to the spindle fibers by their centromeres. Animal cell cleavage furrow formation is caused by a ring of actin microfilaments called the contractile ring, which forms during early anaphase. Myosin is present in the region of the contractile ring as concentrated microfilaments and actin filaments are predominant in this region. The actin filaments here are both pre-existing and new. Cleavage is driven by these motor proteins, actin and myosin, which are the same proteins involved with muscle contraction. During cellular cleavage, the contractile ring tightens around the cytoplasm of the cell until the cytoplasm is pinched into two daughter cells. During the final phase of mitosis, telophase, the furrow forms an intercellular bridge using mitotic spindle fibers. Phosphatidylethanolamine (PE) has been shown to be present during this time which indicates that is may play a role in movement between the plasma membrane and contractile ring. The bridge is then broken and resealed to form two identical daughter cells during cytokinesis. The breakage is formed by microtubules and the resealing is negated by Calcium dependent exocytosis using Golgi vesicles. In comparison, the plant cell septum and the animal cell mid-zone are analogous. Both require vesicular secretions by the Golgi apparatus for resealing and formation of the cytoskeletal network in addition to microtubules and microfilaments for division and movement. The cleavage furrow mechanism in animal cells is a complex network of actin and myosin filaments, Golgi vesicles and Calcium dependent channels enabling the cell to break apart, reseal and form new daughter cells with complete membranes. | https://en.wikipedia.org/wiki?curid=376924 | 1,232,221 |
1,366,711 | Online learning environments however tend to reflect the cultural, epistemological, and pedagogical goals and assumptions of their designers. In computer-supported collaborative learning environments, there is evidence that cultural background may impact learner motivation, attitude towards learning and e-learning, learning preference (style), computer usage, learning behavior and strategies, academic achievement, communication, participation, knowledge transfer, sharing and collaborative learning. Studies variously comparing Asian, American and Danish and Finnish learners have suggested that learners from different cultures exhibit different interaction patterns with their peers and teachers in online. A number of studies have shown that difference in Eastern and Western educational cultures, for instance, which are found in traditional environments are also present in online environments. Zhang has described Eastern education as more group-based, teacher-dominated, centrally organized, and examination-oriented than Western approaches. Students who have learned to learn in an Eastern context emphasizing teacher authority and standardized examinations may perform differently in a CSCL environment characterized by peer critique and co-construction of educational artifacts as the primary mode of assessment. | https://en.wikipedia.org/wiki?curid=4548948 | 1,365,955 |
1,079,592 | During his association with Carl Zeiss' microscope works, not only was he at the forefront of the field of optics but also labor reform. He founded the social democratic Jenaische Zeitung (newspaper) in 1890 and in 1900, introduced the eight-hour workday, in remembrance of the 14-hour workday of his own father. In addition, he created a pension fund and a discharge compensation fund. In 1889, Ernst Abbe set up and endowed the Carl Zeiss Foundation for research in science. The aim of the foundation was "to secure the economic, scientific, and technological future and in this way to improve the job security of their employees." He made it a point that the success of an employee was based solely on their ability and performance, not on their origin, religion, or political views. In 1896, he reorganized the Zeiss optical works into a cooperative with profit-sharing. His social views were so respected as to be used by the Prussian state as a model and idealized by Alfred Weber in the 1947 book "Schriften der Heidelberger Aktionsgruppe zur Demokratie und Zum Freien Sozialismus". | https://en.wikipedia.org/wiki?curid=524981 | 1,079,037 |
651,322 | The H in the F2H of 1978 denoted "High Speed". It was yet another titanium-armored F2 but this time with a fixed (not reflex), semi-silvered, pellicle mirror, manual lens diaphragm control and a mechanically matched titanium-armored Nikon MD-100 high-speed motor drive. The maximum shutter speed is 1/1000 (vs. 1/2000 for other F2 models). The self-timer and shutter settings 'B' and 'T' were omitted. The depth-of-field preview button was replaced with a 'Full-Aperture Viewing Button'. The Nikon MD-100 motor drive was a modified version of the MD-2 motor drive and was powered by the Nikon MB-100. The MB-100 consists of two MB-1 battery packs (20 AA or LR6 batteries, or four Nikon MN-1 nickel-cadmium rechargeable batteries, providing 30 volts), weighing a massive 960 g empty and reaching 10 frames-per-second film advance rate. The F2H set included the Nikon MH-100 battery charger. All components (body, motor and batterypack) may be detached from each other. The bodies (7-digit serial number) and motordrives (6-digit serial number) do not have matching serial numbers, contrary to often repeated misinformation. Body serial numbers began with 7850001, e.g. 'F2 7850001'. Approximately 400 units were produced making the F2H extremely rare, the rarest of any 'production model' F2, and valuable. | https://en.wikipedia.org/wiki?curid=3146672 | 650,980 |
1,869,568 | The thin lacustrine interbeds of the Mawson Formation have received several names in literature, being known as either Carapace Sandstone or Carapace Formation, being a series of Freshwater environments developed during times when the Kirkpatrick Basalt stopped invading the zone. The lava flow deposits of the Kirkpatrick Basalt belong to the Ferrar Large Igneous Province, developed in a linear belt along the Transantarctic Mountains, from the Weddell Sea region to North Victoria Land, covering approx. 3,500 km in length. This event was linked with the initial stages of the breakup of the Gondwanan part of Pangea, concretely with the rifting of East Antarctica and Southern Africa, developing a magmatic flow controlled by an Early Jurassic zone of extension related to a triple junction in the proto-Weddell Sea region at approximately 55°S. This eruptions phase includes the Dufek Intrusion, the Ferrar Dolerite sills and dikes, extrusive rocks consisting of pyroclastic strata, and the Kirkpatrick Basalt lava flows, with a total thickness variable, but exceeding 2 km in some places. This Volcanism is not limited to the Antarctica, as it was recorded also in Tasmania and New Zealand, suggesting that these area where connected back then. | https://en.wikipedia.org/wiki?curid=62202084 | 1,868,492 |
1,721,311 | This involves the approval of a product for sale in a jurisdiction. Typically a national agency such as the US Food and Drug Administration (specifically, the Center for Drug Evaluation and Research, or CDER), the UK Medicines and Healthcare products Regulatory Agency or Health Canada or Ukrainian Drug Registration Agency is responsible for reviewing a product and approving it for sale. The regulatory process typically focuses on quality, safety and efficacy. To be approved for sale a product must demonstrate that it is generally safe (or has a favourable risk/benefit profile relative to the condition it is intended to treat), that it does what the manufacturer claims and that it is produced to high standards. Internal staff and expert advisory committees review products. Once approved, a product is given an approval letter or issued with a notice of compliance, indicating that it may now be sold in the jurisdiction. In some cases, such approvals may have conditions attached, requiring, for example additional 'post-marketing' trials to clarify an issue (such as efficacy in certain patient populations or interactions with other products) or criteria limiting the product to certain uses. | https://en.wikipedia.org/wiki?curid=10338164 | 1,720,341 |
1,473,804 | Button qualified seventh, but incurred a five-place grid penalty for changing his gearbox, promoting his teammate Magnussen to seventh. Although Räikkönen in eighth improved his car's balance, he slid multiple times after a unrectifiable frontal problem, creating understeer. Sutil took ninth and Maldonado, who was the fastest driver not to advance into the final session, was tenth, after sliding in turn 19, losing about two-tenths of a second, preventing an improvement. Sergio Pérez, 11th, used two sets of soft tyres in the first session to get into the second. Hülkenberg, 13th, was forecast to qualify in the top ten until a tear-off visor wrapped itself around a front tyre into turn 12, losing grip, ran wide, and lost time. Kvyat complained of tyre temperature issues in slower traffic on his out-lap. However, he incurred a ten-place grid penalty for changing an engine component. His teammate Vergne started 14th and was the fastest driver not to enter the second session, attributing the result to switching to an older, less powerful engine and excess oversteer. Esteban Gutiérrez took 15th ahead of Grosjean. Vettel in 17th opted to do one lap on soft tyres to comply with the 107 per cent rule. He began from the pit lane after changing his engine, his sixth of the season. | https://en.wikipedia.org/wiki?curid=38847467 | 1,472,973 |
1,387,841 | In June 2010 the 2008–2009 Annual Report of the President's Cancer Panel was released and recommended: "Because of the long latency period of many cancers, the available evidence argues for a precautionary approach to these diverse chemicals, which include (…) bisphenol A". In August 2010, the Maine Board of Environmental Protection voted unanimously to ban the sale of baby bottles and other reusable food and beverage containers made with bisphenol A as of January 2012. In February 2011, the newly elected governor of Maine, Paul LePage, gained national attention when he spoke on a local TV news show saying he hoped to repeal the ban because, "There hasn't been any science that identifies that there is a problem" and added: "The only thing that I've heard is if you take a plastic bottle and put it in the microwave and you heat it up, it gives off a chemical similar to estrogen. So the worst case is some women may have little beards." In April 2011, the Maine legislature passed a bill to ban the use of BPA in baby bottles, sippy cups, and other reusable food and beverage containers, effective 1 January 2012. Governor LePage refused to sign the bill. | https://en.wikipedia.org/wiki?curid=57552333 | 1,387,074 |
883,677 | In recent years, the increased sophistication and accessibility of eye-tracking technologies have generated a great deal of interest in the commercial sector. Applications include web usability, advertising, sponsorship, package design and automotive engineering. In general, commercial eye-tracking studies function by presenting a target stimulus to a sample of consumers while an eye tracker records eye activity. Examples of target stimuli may include websites, television programs, sporting events, films and commercials, magazines and newspapers, packages, shelf displays, consumer systems (ATMs, checkout systems, kiosks) and software. The resulting data can be statistically analyzed and graphically rendered to provide evidence of specific visual patterns. By examining fixations, saccades, pupil dilation, blinks and a variety of other behaviors, researchers can determine a great deal about the effectiveness of a given medium or product. While some companies complete this type of research internally, there are many private companies that offer eye-tracking services and analysis. | https://en.wikipedia.org/wiki?curid=1543423 | 883,213 |
182,337 | At the 99th IOC Session in July 1992, the IOC voted to approve women's hockey as an Olympic event beginning with the 1998 Winter Olympics as part of their effort to increase the number of female athletes at the Olympics. Women's ice hockey had not been in the programme when Nagano, Japan had won the right to host the Olympics in June 1991, and the decision required approval by the Nagano Winter Olympic Organizing Committee (NAOOC). The NAOOC was initially hesitant to include the event because of the additional costs of staging the tournament and because they felt their team, which had failed to qualify for that year's World Championships, could not be competitive. According to Glynis Peters, the Canadian Amateur Hockey Association's (CAHA) head of female hockey, "the Japanese would have to finance an entirely new sports operation to bring their team up to Olympic standards in six years, which they were also really reluctant to do." In November 1992, the NWOOC and IOC Coordination Committee reached an agreement to include a women's ice hockey tournament in the programme. Part of the agreement was that the tournament would be limited to six teams, and no additional facilities would be built. The CAHA also agreed to help build and train the Japanese team so that it could be more competitive. The IOC had agreed that if the NAOOC had not approved the event, it would be held at the 2002 Winter Olympics. The format of the first tournament was similar to the men's: preliminary round-robin games followed by a medal round playoff. | https://en.wikipedia.org/wiki?curid=1855215 | 182,241 |
1,685,117 | Natural history in the eighteenth century was the "nomination of the visible". Carl Linnaeus was preoccupied with fitting all nature into taxonomy, fixated on only what was visible. Towards the turn of the eighteenth century, Immanuel Kant became interested in understanding where species derived from, and was less concerned with an organism's physical attributes. Next, Johann Reinhold Forster, one of Humboldt's future partners, became interested in the study of vegetation as an essential way of understanding nature and its relationship with human society. Proceeding Forster, Karl Willdenow examined floristic plant geography, the distribution of plants and regionality as a whole. All of these pieces in the history before Humboldt help to shape what is defined as Humboldtian science. Humboldt took into account both the outward appearance and inward meaning of plant species. His attention to natural aesthetics and empirical data and evidence is what set his scientific work apart from ecologists before him. Nicolson so aptly puts it as: "Humboldt effortlessly combined a commitment to empiricism and the experimental elucidation of the laws of nature with an equally strong commitment to holism and to a view of nature which was intended to be aesthetically and spiritually satisfactory". It was through this holistic approach to science and the study of nature that Humboldt was able to find a web of interconnectedness despite a multitude of extensive differences between different species of organisms. | https://en.wikipedia.org/wiki?curid=8243937 | 1,684,172 |
144,219 | Higher performing solid rocket propellants are used in large strategic missiles (as opposed to commercial launch vehicles). HMX, CHN(NO), a nitramine with greater energy than ammonium perchlorate, was used in the propellant of the Peacekeeper ICBM and is the main ingredient in NEPE-75 propellant used in the Trident II D-5 Fleet Ballistic Missile. It is because of explosive hazard that the higher energy military solid propellants containing HMX are not used in commercial launch vehicles except when the LV is an adapted ballistic missile already containing HMX propellant (Minotaur IV and V based on the retired Peacekeeper ICBMs). The Naval Air Weapons Station at China Lake, California, developed a new compound, CHN(NO), called simply CL-20 (China Lake compound 20). Compared to HMX, CL-20 has 14% more energy per mass, 20% more energy per volume, and a higher oxygen-to-fuel ratio. One of the motivations for development of these very high energy density military solid propellants is to achieve mid-course exo-atmospheric ABM capability from missiles small enough to fit in existing ship-based below-deck vertical launch tubes and air-mobile truck-mounted launch tubes. CL-20 propellant compliant with Congress' 2004 insensitive munitions (IM) law has been demonstrated and may, as its cost comes down, be suitable for use in commercial launch vehicles, with a very significant increase in performance compared with the currently favored APCP solid propellants. With a specific impulse of 309 s already demonstrated by Peacekeeper's second stage using HMX propellant, the higher energy of CL-20 propellant can be expected to increase specific impulse to around 320 s in similar ICBM or launch vehicle upper stage applications, without the explosive hazard of HMX. | https://en.wikipedia.org/wiki?curid=37830 | 144,161 |
65,269 | During these battles, the Nationalist Sabres introduced a new element into aerial warfare. Under a secret effort designated Operation Black Magic, the U.S. Navy had provided the ROC with the AIM-9 Sidewinder, its first infrared-homing air-to-air missile, which was just entering service with the United States. A small team from VMF-323, a Marine FJ-4 Fury squadron with later assistance from China Lake and North American Aviation, initially modified 20 of the F-86 Sabres to carry a pair of Sidewinders on underwing launch rails and instructed the ROC pilots in their use flying profiles with USAF F-100s simulating the MiG-17. The MiGs enjoyed an altitude advantage over the Sabres, as they had in Korea, and Communist Chinese MiGs routinely cruised over the Nationalist Sabres, only engaging when they had a favorable position. The Sidewinder took away that advantage and proved to be devastatingly effective against the MiGs. | https://en.wikipedia.org/wiki?curid=359331 | 65,244 |
833,869 | The light emitted by most VFDs contains many colors and can often be filtered to enhance the color saturation providing a deep green or deep blue, depending on the whims of the product's designers. Phosphors used in VFDs are different from those in cathode-ray displays since they must emit acceptable brightness with only around 50 volts of electron energy, compared to several thousand volts in a CRT. The insulating layer in a VFD is normally black, however it can be removed to allow the display to be transparent. AMVFD displays that incorporate a driver IC are available for applications that require high image brightness and an increased number of pixels. Phosphors of different colors can be stacked on top of each other for achieving gradations and various color combinations. Hybrid VFDs include both fixed display segments and a graphic VFD in the same unit. VFDs may have display segments, grids and related circuitry on their front and rear plass panels, using a central cathode for both panels, allowing for increased segment density. The segments can also be placed exclusively on the front instead of on the back, improving viewing angles and brightness. | https://en.wikipedia.org/wiki?curid=497899 | 833,420 |
1,538,231 | Born on 15 February 1952, Dipankar Banerjee graduated in metallurgical engineering from the Indian Institute of Technology, Madras in 1974. After gaining a master's degree, he pursued his doctoral studies at the Indian Institute of Science (IISc) to earn a PhD in 1979. His post-doctoral work was at the Aeronautical Research and Development Board of India of the Defence Research and Development Organization (DRDO) as a research fellow and after completing the work, he started his career at the Defence Metallurgical Research Laboratory (DMRL) of DRDO in 1979. He became the director of DMRL in 1996 and held the position until 2003 when he was appointed as the chief controller of research and development of DRDO, overseeing the aeronautical and materials programs of the organization. In 2010, he returned to his alma mater, the IISc, as a professor at the Department of Materials Engineering and heads the "Processing, Structure and Properties of Materials Laboratory" (PSPM) as its group leader. During this period, he had several stints on research assignments in the US which included those at the Carnegie Mellon University, the Los Alamos National Laboratory and the General Electric Research Laboratory. He is a former chair of the research council of the National Institute of Interdisciplinary Science and Technology and the incumbent chair of the researchcouncil of Central Glass and Ceramics Research Institute of CSIR and the Gas Turbine Materials (GTMAP) program of the Aeronautics Research and Development Board of DRDO. He is a former president and the incumbent member of the council of the Indian Institute of Metals and sits in the governing board of the Indian Institute of Technology, Madras. The memberships of the board of governors of Mishra Dhatu Nigam and the strategic advisory committee of the Mining and Metallurgical Society of America were some of his other past assignments. | https://en.wikipedia.org/wiki?curid=56079268 | 1,537,358 |
2,139,421 | After returning from the winter break, Rensselaer was forced to postpone or cancel several games in early January due to an increase in positive COVID-19 tests. When they did began playing games, the team also found itself in need of a new starting goaltender as presumptive primary netminder, Linden Marshall, had not performed well enough to retain the job. Newcomer Jack Watson was a bit inconsistent in his early appearances, but he possessed a higher ceiling than Marshall and Dave Smith eventually settled on the freshman as the starter. The offense also saw a steady improvement after returning to action but remained hot and cold for the remainder of the regular season. RPI would regularly follow stunning victories with confounding losses and ended the year just under .500. However, with a 6th-place finish, they did at least receive a home site for the first round of the conference tournament. | https://en.wikipedia.org/wiki?curid=68602559 | 2,138,191 |
720,103 | The first bolometers made by Langley consisted of two steel, platinum, or palladium foil strips covered with lampblack. One strip was shielded from radiation and one exposed to it. The strips formed two branches of a Wheatstone bridge which was fitted with a sensitive galvanometer and connected to a battery. Electromagnetic radiation falling on the exposed strip would heat it and change its resistance. By 1880, Langley's bolometer was refined enough to detect thermal radiation from a cow a quarter of a mile away. This radiant-heat detector is sensitive to differences in temperature of one hundred-thousandth of a degree Celsius (0.00001 C). This instrument enabled him to thermally detect across a broad spectrum, noting all the chief Fraunhofer lines. He also discovered new atomic and molecular absorption lines in the invisible infrared portion of the electromagnetic spectrum. Nikola Tesla personally asked Dr. Langley if he could use his bolometer for his power transmission experiments in 1892. Thanks to that first use, he succeeded in making the first demonstration between West Point and his laboratory on Houston Street. | https://en.wikipedia.org/wiki?curid=98918 | 719,723 |
1,181,513 | A variant of the land bridge hypothesis has been proposed in an attempt to explain both how a land bridge could have formed, and why other mammalian orders failed to cross it. Geological studies have shown that following the collision of India and Asia, the Davie Fracture Zone had been pushed up by tectonic forces, possibly high enough to create a land bridge. Indeed, core samples along the Davie Fracture Zone suggest that at least parts of the Mozambique Channel were above sea level between 45 and 26 mya, or possibly as early as 55 mya. Following the Indian-Asian collision, the fault type changed from a strike-slip fault to a normal fault, and seafloor spreading created compression along the Davie Fracture Zone, causing it to rise. By the early Miocene, the East African Rift created tension along the fault, causing it to subside beneath the ocean. The divergence dates of many Malagasy mammalian orders formerly fell within this window. Old World monkeys, dogs, and cats did not diverge or arrive in Africa until later in the Miocene. However, more recent dating of divergence of the Malagasy mammalian clades falls outside of this land bridge window, and a much greater diversity of mammal groups would be expected on Madagascar had the land bridge been present during that stretch of time. | https://en.wikipedia.org/wiki?curid=26770557 | 1,180,889 |
502,670 | Trace evidence is sometimes an important factor in reconstructing the sequence of events in an accident. For example, tire burn marks on a road surface can enable vehicle speeds to be estimated, when the brakes were applied and so on. Ladder feet often leave a trace of movement of the ladder during a slip and may show how the accident occurred. When a product fails for no obvious reason, SEM and Energy-dispersive X-ray spectroscopy (EDX) performed in the microscope can reveal the presence of aggressive chemicals that have left traces on the fracture or adjacent surfaces. Thus an acetal resin water pipe joint suddenly failed and caused substantial damages to a building in which it was situated. Analysis of the joint showed traces of chlorine, indicating a stress corrosion cracking failure mode. The failed fuel pipe junction mentioned above showed traces of sulfur on the fracture surface from the sulfuric acid, which had initiated the crack. | https://en.wikipedia.org/wiki?curid=69817 | 502,412 |
1,701,321 | An even more controversial direction was taken for the new university based on a daring vision that higher education should be completely separated from religious doctrine. One of the largest construction projects in North America up to that time, the new Grounds were centered upon a library (then housed in the Rotunda) rather than a church – further distinguishing it from peer universities of the United States, most of which were still primarily functioning as seminaries for one particular religion or another. Jefferson even went so far as to ban the teaching of theology altogether. In a letter to Thomas Cooper in October 1814, Jefferson stated, "a professorship of theology should have no place in our institution" and, true to form, the university has never had a divinity school; it was established independent of any religious sect. Replacing the then-standard specialization in religion, the university undertook groundbreaking specializations in scientific subjects such as astronomy and botany. (However, today UVA does maintain a strong religious studies department. A non-denominational chapel, notably absent from Jefferson's original plans, was constructed in 1890.) | https://en.wikipedia.org/wiki?curid=42259670 | 1,700,367 |
1,143,041 | A driverless tractor is an autonomous farm vehicle that delivers a high tractive effort (or torque) at slow speeds for the purposes of tillage and other agricultural tasks. It is considered driverless because it operates without the presence of a human inside the tractor itself. Like other unmanned ground vehicles, they are programmed to independently observe their position, decide speed, and avoid obstacles such as people, animals, or objects in the field while performing their task. The various driverless tractors are split into full autonomous technology and supervised autonomy. The idea of the driverless tractor appears as early as 1940, but the concept has significantly evolved in the last few years. The tractors use GPS and other wireless technologies to farm land without requiring a driver. They operate simply with the aid of a supervisor monitoring the progress at a control station or with a manned tractor in lead. | https://en.wikipedia.org/wiki?curid=38711859 | 1,142,444 |
822,515 | Capital budgeting, in relation to engineering economics, is the proper usage and utilization of capital to achieve project objectives. It can be fully defined by the statement; "... as the series of decisions by individuals and firms concerning how much and where resources will be obtained and expended to meet future objectives." This definition almost perfectly explains capital and its general relation to engineering, though some special cases may not lend themselves to such a concise explanation. The actual acquisition of that capital has many different routes, from equity to bonds to retained profits, each having unique strengths and weakness, especially when in relation to income taxation. Factors such as risk of capital loss, along with possible or expected returns must also be considered when capital budgeting is underway. For example, if a company has $20,000 to invest in a number of high, moderate, and low risk projects, the decision would depend upon how much risk the company is willing to take on, and if the returns offered by each category offset this perceived risk. Continuing with this example, if the high risk offered only 20% return, while the moderate offered 19% return, engineers and managers would most likely choose the moderate risk project, as its return is far more favorable for its category. The high risk project failed to offer proper returns to warrant its risk status. A more difficult decision may be between a moderate risk offering 15% while a low risk offering 11% return. The decision here would be much more subject to factors such as company policy, extra available capital, and possible investors. "In general, the firm should estimate the project opportunities, including investment requirements and prospective rates of return for each, expected to be available for the coming period. Then the available capital should be tentatively allocated to the most favorable projects. The lowest prospective rate of return within the capital available then becomes the minimum acceptable rate of return for analyses of any projects during that period." | https://en.wikipedia.org/wiki?curid=7977203 | 822,074 |
133,322 | The beginning of the 20th century brought the start of a revolution in physics. The long-held theories of Newton were shown not to be correct in all circumstances. Beginning in 1900, Max Planck, Albert Einstein, Niels Bohr and others developed quantum theories to explain various anomalous experimental results, by introducing discrete energy levels. Not only did quantum mechanics show that the laws of motion did not hold on small scales, but the theory of general relativity, proposed by Einstein in 1915, showed that the fixed background of spacetime, on which both Newtonian mechanics and special relativity depended, could not exist. In 1925, Werner Heisenberg and Erwin Schrödinger formulated quantum mechanics, which explained the preceding quantum theories. The observation by Edwin Hubble in 1929 that the speed at which galaxies recede positively correlates with their distance, led to the understanding that the universe is expanding, and the formulation of the Big Bang theory by Georges Lemaître. Currently, general relativity and quantum mechanics are inconsistent with each other, and efforts are underway to unify the two. | https://en.wikipedia.org/wiki?curid=14400 | 133,269 |
1,427,231 | Leijonhufvud's monetary economics built on the work of the American economist Robert W. Clower. In 1968, at the age of 35, he published a famous scholarly book entitled "On Keynesian Economics and the Economics of Keynes". In the book, he argued that Keynesian economics had to be re-examined. He made the case that John Hicks' IS/LM (Investment—Saving / Liquidity preference—Money supply) formulation of Keynes "General Theory" was an inadequate explanation for the "involuntary unemployment" in John Maynard Keynes's writings. Rather, Leijonhufvud's reading of Keynes emphasizes disequilibrium phenomena, which cannot be addressed in the IS/LM framework, as central to Keynes' explanation of unemployment and economic depression. Leijonhufvud used this observation as a point of departure to advocate a "cybernetic" approach to macroeconomics, where the algorithm by which prices and quantities adjust is explicitly specified, allowing the dynamic economy to be studied without imposing the standard Walrasian equilibrium concept. In particular, Leijonhufvud advocated formally modelling the process by which information moves through the economy. While the "cybernetic" approach may have failed to gain traction in mainstream economics, it presaged the rational expectations revolution that would ultimately supplant the IS/LM model as the dominant paradigm in academic macroeconomics. | https://en.wikipedia.org/wiki?curid=15742838 | 1,426,428 |
384,629 | Nitrosamines can be formed during the curing process used to preserve meats, when sodium nitrite-treated meat is cooked, and also from the reaction of nitrite with secondary amines under acidic conditions (such as occurs in the human stomach). Dietary sources of nitrosamines include US cured meats preserved with sodium nitrite as well as the dried salted fish eaten in Japan. In the 1920s, a significant change in US meat curing practices resulted in a 69% decrease in average nitrite content. This event preceded the beginning of a dramatic decline in gastric cancer mortality. Around 1970, it was found that ascorbic acid (vitamin C), an antioxidant, inhibits nitrosamine formation. Consequently, the addition of at least 550 ppm of ascorbic acid is required in meats manufactured in the United States. Manufacturers sometimes instead use erythorbic acid, a cheaper but equally effective isomer of ascorbic acid. Additionally, manufacturers may include α-tocopherol (vitamin E) to further inhibit nitrosamine production. α-Tocopherol, ascorbic acid, and erythorbic acid all inhibit nitrosamine production by their oxidation-reduction properties. Ascorbic acid, for example, forms dehydroascorbic acid when oxidized, which when in the presence of nitrosonium, a potent nitrosating agent formed from sodium nitrite, reduces the nitrosonium into nitric oxide. The nitrosonium ion formed in acidic nitrite solutions is commonly mislabeled nitrous anhydride, an unstable nitrogen oxide that cannot exist in vitro. | https://en.wikipedia.org/wiki?curid=407615 | 384,434 |
326,912 | In January 2004, the UK Ministry of Defence announced the selection of an A330 MRTT variant to provide tanking for the RAF for the next 30 years under the Future Strategic Tanker Aircraft (FSTA) programme, replacing the RAF's TriStar and VC10 tankers. The Ministry of Defence entered negotiations with the EADS-led AirTanker consortium. On 27 March 2008, a deal was signed to lease 14 MRTTs under a private finance initiative arrangement with AirTanker, with the first to enter service in 2011. The service's annual cost, including military personnel costs is around £450 million for a delivery of 18,000 flying hours a rate of approximately £25,000 per hour. There are two versions, designated "Voyager KC.Mk 2" and "Voyager KC.Mk 3"; the former is fitted with two Cobham 905E under-wing refuelling pods, the latter with a Cobham 805E Fuselage Refuelling Unit (FRU) in addition to the under-wing pods; none are fitted with the Aerial Refuelling Boom System (ARBS). All Voyagers are powered by a pair of Rolls-Royce Trent 772B-60 engines. | https://en.wikipedia.org/wiki?curid=616482 | 326,738 |
1,963,548 | The CDRD has developed a helium balloon-based stationary surveillance platform equipped with pan–tilt–zoom and infrared cameras, demining machines, voice encryption devices for telephones and radios, high nutrition/ high caloric ration packs alongside packaging material and containers, GPS-based vehicle tracking devices and fleet management Systems, WS30 stabilized weapon system for naval vessels developed in cooperation with EM Digital. The CDRD has also developed numerous simulators for training including realistic flight simulator, flight control simulator, field artillery simulator, simulators for jungle lane firing etc. CDRD also developed civilian use technologies such as a Train Tracking and Operating Information System for Sri Lankan Railways, Braille to Sinhala converter, bullet proof vest , GPS-enabled quadcopters alongside 3D modeling tools for drone mapping and disaster management as well as a web-based Global Disaster Risk Analysis, Prevention and Mitigation Application. | https://en.wikipedia.org/wiki?curid=64487376 | 1,962,420 |
868,482 | Armour-piercing, composite rigid (APCR) in British nomenclature, high-velocity armour-piercing (HVAP) in US nomenclature, and 'hard core ammunition' () in German nomenclature, is a projectile which has a core of high-density hard material, such as tungsten carbide, surrounded by a full-bore shell of a lighter material (e.g., an aluminium alloy). However, the low sectional density of the APCR resulted in high aerodynamic drag. Tungsten compounds such as tungsten carbide were used in small quantities of inhomogeneous and discarded sabot round, but that element was in short supply in most places. Most APCR projectiles are shaped like the standard APCBC round (although some of the German "Pzgr." 40 and some Soviet designs resemble a stubby arrow), but the projectile is lighter: up to half the weight of a standard AP round of the same calibre. The lighter weight allows a higher muzzle velocity. The kinetic energy of the round is concentrated in the core and hence on a smaller impact area, improving the penetration of the target armour. To prevent shattering on impact, a shock-buffering cap is placed between the core and the outer ballistic shell as with APC rounds. However, because the round is lighter but still the same overall size it has poorer ballistic qualities, and loses velocity and accuracy at longer ranges. The APCR was superseded by the APDS, which dispensed with the outer light alloy shell once the round had left the barrel. The concept of a heavy, small-diameter penetrator encased in light metal was later employed in small-arms armour-piercing incendiary and HEIAP rounds. | https://en.wikipedia.org/wiki?curid=79266 | 868,022 |
549,668 | The earliest discovery of a burrowing "Thrinaxodon" places the specimen found around 251 million years ago, a time frame surrounding the Permian–Triassic extinction event. Much of these fossils had been found in the flood plains of South Africa, in the Karoo Basin. This behavior had been seen at a relatively low occurrence in the pre-Cenozoic, dominated by therapsids, early-Triassic cynodonts and some early Mammalia. "Thrinaxodon" was in fact the first burrowing cynodont that has been found, showing similar behavioral patterns to that of Trirachodon. The first burrowing vertebrate on record was the dicynodont synapsid "Diictodon", and it is possible that these burrowing patterns had passed on to the future cynodonts due to the adaptive advantage of burrowing during the extinction. The burrow of "Thrinaxodon" consists of two laterally sloping halves, a pattern that has only been observed in burrowing non-mammalian Cynodontia. The changes in vertebral/rib anatomy that arose in "Thrinaxodon" permit the animals to a greater range of flexibility, and the ability to place their snout underneath their hindlimbs, an adaptive response to small living quarters, in order to preserve warmth and/or for aestivation purposes. | https://en.wikipedia.org/wiki?curid=2969781 | 549,380 |
216,573 | On 13 June 2012, a major milestone of the HMP was announced by the National Institutes of Health (NIH) director Francis Collins. The announcement was accompanied with a series of coordinated articles published in Nature and several journals in the Public Library of Science (PLoS) on the same day. By mapping the normal microbial make-up of healthy humans using genome sequencing techniques, the researchers of the HMP have created a reference database and the boundaries of normal microbial variation in humans. From 242 healthy U.S. volunteers, more than 5,000 samples were collected from tissues from 15 (men) to 18 (women) body sites such as mouth, nose, skin, lower intestine (stool), and vagina. All the DNA, human and microbial, were analyzed with DNA sequencing machines. The microbial genome data were extracted by identifying the bacterial specific ribosomal RNA, 16S rRNA. The researchers calculated that more than 10,000 microbial species occupy the human ecosystem, and they have identified 81–99% of the genera. | https://en.wikipedia.org/wiki?curid=205464 | 216,465 |
195,774 | Further major construction largely ceased on the site until the groundbreaking for the College of Humanities Arts and Social Sciences (CHASS) in April 1951. A group of five buildings designed by different architects in a decidedly more Modern style were completed by 1954: the Rivera Library, Webber Hall, Geology Building, Physical Education Building and Watkins Hall. After the Regents declared UCR a "general campus" of the UC system in 1958, many new buildings and additions were laid out over the following decade. Following an east–west axis, new student residence halls and athletic facilities were developed along the southeastern quadrant of the main campus, while academic and research facilities were built along the central campus area closer to the freeway. The Bell Tower, one of only five carillons in California, was built in this period. Designed by A. Quincy Jones, the tower is tall and contains 48 bells, each weighing from to , covering four chromatic octaves. | https://en.wikipedia.org/wiki?curid=230311 | 195,674 |
1,359,440 | The first courses at the Royal Engineers Establishment were done on an all ranks basis with the greatest regard to economy. To reduce staff the NCOs and officers were responsible for instructing and examining the soldiers. If the men could not read or write they were taught to do so and those that could read and write were taught to draw and interpret simple plans. The Royal Engineers Establishment quickly became the centre of excellence for all fieldwork's and bridging. Pasley was keen to confirm his teaching and regular exercises were held as demonstrations or as experiments to improve the techniques and teaching of the Establishment. From 1833 bridging skills were demonstrated annually by the building of a pontoon bridge across the Medway which was proved by the infantry of the garrison and the cavalry from Maidstone. These demonstrations had become a popular spectacle for the local people by 1843, when 43,000 came to watch a field day laid on to test a method of assaulting earthworks for a report to the Inspector General of Fortifications. In 1869 the title of the Royal Engineers Establishment was changed to "The School of Military Engineering" (SME) as evidence of its status, not only as the font of engineer doctrine and training for the British Army, but also as the leading scientific military school in Europe. | https://en.wikipedia.org/wiki?curid=3125065 | 1,358,689 |
1,381,723 | The International Code Council is focused on assuming the community's buildings support the resilience of communities ahead of disasters. The process presented by the ICC includes understanding the risks, identifying strategies for the risks, and implementing those strategies. Risks vary based on communities, geographies and other factors. The American Institute of Architects created a list of shocks and stresses that are related to certain community characteristics. Shocks are natural forms of hazards (floods, earthquakes), while stresses are more chronic events that can develop over a longer period of time (affordability, drought). It is important to understand the application of resilient design on both shocks and stresses as buildings can play a part in contributing to their resolution. Even though the IBC is a model code, it is adopted by various state and governments to regulate specific building areas. Most of the approaches to minimizing risks are organized around building use and occupancy. In addition, the safety of a structure is determined by material usage, frames, and structure requirements can provide a high level of protection for occupants. Specific requirements and strategies are provided for each shock or stress such as with tsunamis, fires and earthquakes. | https://en.wikipedia.org/wiki?curid=40050529 | 1,380,960 |
771,133 | Various control programs aim to stop onchocerciasis from being a public health problem. The first was the Onchocerciasis Control Programme (OCP), which was launched in 1974, and at its peak, covered 30 million people in 11 countries. Through the use of larvicide spraying of fast-flowing rivers to control black fly populations, and from 1988 onwards, the use of ivermectin to treat infected people, the OCP eliminated onchocerciasis as a public health problem. The OCP, a joint effort of the World Health Organization, the World Bank, the United Nations Development Programme, and the UN Food and Agriculture Organization, was considered to be a success, and came to an end in 2002. Continued monitoring ensures onchocerciasis cannot reinvade the area of the OCP.Effective prevention efforts include personal protection from black fly bites. Recommended protection measures include using insect repellents and wearing long sleeves and pants to eliminate exposed skin.Using insect repellent that contains N,N-Diethyl-meta-toluamide (DEET) as well as clothing treated with permethrin, an insecticide, can provide additional protection from black fly bites. | https://en.wikipedia.org/wiki?curid=276846 | 770,719 |
400,171 | In the middle of February 1945, back in fighting trim, the carrier steamed for Ulithi, arriving on 13 March. She set off westward for strikes on Japan on 14 March and four days later launched strikes against airfields on Kyūshū. That morning a twin-engined Japanese G4M "Betty" broke through a curtain of defensive fire, turned toward "Intrepid", and exploded 50 ft (15 m) off "Intrepid"s forward boat crane. A shower of flaming gasoline and aircraft parts started fires on the hangar deck, but damage control teams quickly put them out. "Intrepid"s aircraft joined attacks on remnants of the Japanese fleet anchored at Kure damaging 18 enemy naval vessels, including battleship "Yamato" and carrier . The carriers turned to Okinawa as L-Day, the start of the most ambitious amphibious assault of the Pacific war, approached. Between 26 and 27 March, their aircraft attacked the Ryūkyūs, softening up enemy defensive works. The invasion began on 1 April. "Intrepid" aircraft flew support missions against targets on Okinawa and made neutralizing raids against Japanese airfields in range of the island. On 16 April, during an air raid, a Japanese aircraft dived into "Intrepid"s flight deck; the engine and part of the fuselage penetrated the deck, killing eight men and wounding 21. In less than an hour the flaming gasoline had been extinguished; three hours after the crash, aircraft were again landing on the carrier. | https://en.wikipedia.org/wiki?curid=245903 | 399,972 |
878,149 | By 1981, laboratory members including Terry Walters, Tom Abrams, and Robert Hawkins had been able to extend the "Aplysia" system into the study of classical conditioning, a finding that helped close the apparent gap between the simple forms of learning often associated with invertebrates and more complex types of learning more often recognized in vertebrates. Along with the fundamental behavioral studies, other work in the lab traced the neuronal circuits of sensory neurons, interneurons, and motor neurons involved in the learned behaviors. This allowed analysis of the specific synaptic connections that are modified by learning in the intact animals. The results from Kandel's laboratory provided solid evidence for the mechanistic basis of learning as "a change in the functional effectiveness of previously existing excitatory connections." Kandel's winning of the 2000 Nobel Prize in Physiology or Medicine was a result of his work with "Aplysia" on the biological mechanisms of memory storage. | https://en.wikipedia.org/wiki?curid=193622 | 877,687 |
1,902,015 | Grazier was hired at the Jet Propulsion Laboratory while still in graduate school to write mission planning and analysis software, used primarily by the Cassini/Huygens Mission. Upon completion of his Ph.D., he was hired full-time onto Cassini as a Science System Engineer (later Science Planning Engineer) and, a short time later, as Investigation Scientist for the Imaging Science Subsystem—the visible light camera aboard the spacecraft. As a Science Planning Engineer, Grazier co-wrote an award-winning program called EVENTS which determined event times when spacecraft can make many different types of observations. Later, Grazier created the Cassini Tour Atlas, a large database with geometrical values and event times, used for mission and observation planning, flight rule constraint checking, and data analysis. Grazier led a small team that designed software to automatically regenerate the Tour Atlas for hypothetical spacecraft trajectories, or when the actual trajectory was subject to change. This software saved Cassini an estimated quarter of a million dollars, and earned a NASA Space Act Award, a NASA Board Act Award, and a NASA Tech Brief Award. | https://en.wikipedia.org/wiki?curid=46885105 | 1,900,925 |
1,546,343 | The phosphorus atom in phosphines has a formal oxidation state −3 (σλ) and are the phosphorus analogues of amines. Like amines, phosphines have a trigonal pyramidal molecular geometry although often with smaller C-E-C angles (E = N, P), at least in the absence of steric effects. The C-P-C bond angle is 98.6° for trimethylphosphine increasing to 109.7° when the methyl groups are replaced by "tert"-butyl groups. When used as ligands, the steric bulk of tertiary phosphines is evaluated by their cone angle. The barrier to pyramidal inversion is also much higher than nitrogen inversion to occur, and therefore phosphines with three different substituents can be resolved into thermally stable optical isomers. Phosphines are often less basic than corresponding amines, for instance the phosphonium ion itself has a p"K" of −14 compared to 9.21 for the ammonium ion; trimethylphosphonium has a p"K" of 8.65 compared to 9.76 for trimethylammonium. However, triphenylphosphine (p"K" 2.73) is more basic than triphenylamine (p"K" −5), mainly because the lone pair of the nitrogen in NPh is partially delocalized into the three phenyl rings. Whereas the lone pair on nitrogen is delocalized in pyrrole, the lone pair on phosphorus atom in the phosphorus equivalent of pyrrole (phosphole) is not. The reactivity of phosphines matches that of amines with regard to nucleophilicity in the formation of phosphonium salts with the general structure PRX. This property is used in the Appel reaction for converting alcohols to alkyl halides. Phosphines are easily oxidized to the corresponding phosphine oxides, whereas amine oxides are less readily generated. In part for this reason, phosphines are very rarely encountered in nature. | https://en.wikipedia.org/wiki?curid=8502542 | 1,545,469 |
75,764 | In keeping with the norms of the time, Kolmer completed a relatively small animal trial with 42 monkeys before proceeding to self experimentation in 1934. He tested his vaccine upon himself, his two children, and his assistant. He gave his vaccine to just 23 more children before declaring it safe and sending it out to doctors and health departments for a larger test of efficacy. By April 1935, he was able to report having tested the vaccine on 100 children without ill effect. Kolmer's first formal presentation of results would not come about until November 1935 where he presented the results of 446 children and adults he had vaccinated with his attenuated vaccine. He also reported that together the Research Institute of Cutaneous Medicine and the Merrell Company of Cincinnati (the manufacturer who held the patent for his ricinoleating process) had distributed 12,000 doses of vaccine to some 700 physicians across the United States and Canada. Kolmer did not describe any monitoring of this experimental vaccination program nor did he provide these physicians with instructions in how to administer the vaccine or how to report side effects. Kolmer dedicated the bulk of his publications thereafter to explaining what he believed to be the cause of the 10+ reported cases of paralytic polio following vaccination, in many cases in towns where no polio outbreak had occurred. Six of these cases had been fatal. Kolmer had no control group but asserted that many more children would have gotten sick. | https://en.wikipedia.org/wiki?curid=192198 | 75,736 |
1,290,610 | Due to the atypical presentation and rarity of the infection, it takes a physician longer to diagnose than more common types of bladder infections. Diagnosis requires a personalized investigation with consideration to risk factors and symptoms. Radiology of the abdominal or pubic region has proven to be an important tool in reaching a definitive diagnosis of conditions causing gas in the urinary tract. Computer tomography, or CT scans, are of most help due to their high sensitivity in detecting gas and air bubbles. However, radiology is normally not the first tool used to diagnose. Most diagnoses are made by chance after imaging examination. Sometimes, even when patients don't show symptoms, their Emphysematous cystitis infection level can be very advanced already. Gas in the bladder wall will often have the appearance of cobblestone or a “beaded necklace” with the use of conventional radiography. Delayed diagnosis can lead to a severe infection, extension of the uterus, rupturing of the bladder, and death. Emphysematous cystitis has an overall mortality rate of 7%. However, surgery is only considered in severe cases where the disease progresses involving the ureters, kidneys, or adrenal glands. When required, surgery may be extensive. | https://en.wikipedia.org/wiki?curid=39900219 | 1,289,900 |
878,150 | Starting in 1966 James Schwartz collaborated with Kandel on a biochemical analysis of changes in neurons associated with learning and memory storage. By this time it was known that long-term memory, unlike short-term memory, involved the synthesis of new proteins. By 1972 they had evidence that the second messenger molecule cyclic AMP (cAMP) was produced in "Aplysia" ganglia under conditions that cause short-term memory formation (sensitization). In 1974 Kandel moved his lab to Columbia University and became founding director of the Center for Neurobiology and Behavior. It was soon found that the neurotransmitter serotonin, acting to produce the second messenger cAMP, is involved in the molecular basis of sensitization of the gill-withdrawal reflex. By 1980, collaboration with Paul Greengard resulted in demonstration that cAMP-dependent protein kinase, also known as protein kinase A (PKA), acted in this biochemical pathway in response to elevated levels of cAMP. Steven Siegelbaum identified a potassium channel that could be regulated by PKA, coupling serotonin's effects to altered synaptic electrophysiology. | https://en.wikipedia.org/wiki?curid=193622 | 877,688 |
2,155,961 | Andrew Lumsden has co-authored a book entitled "The Developing Brain" with Michael Brown and Roger Keynes. Following his PhD on epithelial-mesenchymal interactions in mammalian development, Lumsden's interest moved to the question of how integumental structures, such as teeth and vibrissae acquire their nerve supply, and how the cranial neural crest contributes to their patterning. Studies on the development of the trigeminal nerve and ganglion led on to observations of the organisation of their corresponding motor and sensory regions of the central nervous system. His seminal observations and experiments on the developing hindbrain of mammal and bird embryos confirmed the long suggested but never agreed view that this brain region has a rigidly segmented organisation, much like the body plan of insects and worms. To assist his research, he developed the Lumsden BioScissors™. Most recently, he has focussed on the developing forebrain, where he discovered signalling properties in a small set of cells that pattern the large surrounding region of the thalamus. | https://en.wikipedia.org/wiki?curid=29140493 | 2,154,730 |
1,472,860 | Cardiovascular disease (CVD) is the leading cause of death in women in developed countries, and it is well studied that hypoestrogenism has many regulatory functions in the cardiovascular system. Estradiol (E2), an estrogen steroid hormone and the major female sex hormone, has a cardio-protective effect. As such, hypoestrogenism caused by FHA causes significant impairment in the endothelial and vascular function, NO bioactivity, autonomic function, the renin-angiotensin system, and lipid profiles. It has been hypothesized that premenopausal hypoestrogenemia caused by ovarian disruption, including that induced by FHA, increases the risk for the premature acquisition and accelerated development of atherosclerosis in these patients. In hypoestrogenic women with FHA, measures of flow-mediated dilation (FMD) indicate that the positive effects on endothelial function typically conferred by exercise are not realized, but possibly reversed. It has been suggested that long term estrogen deficiency may alter vasculature structure and responsiveness, as an impaired response to exogenous NO by arterial smooth muscle has been demonstrated in patients with FHA. | https://en.wikipedia.org/wiki?curid=15738568 | 1,472,030 |
744,473 | While the motivating factors behind unequal recombination remain obscure, elements of the physical mechanism have been elucidated. Mismatch repair (MMR) proteins, for instance, are a well-known regulatory family of proteins, responsible for regulating mismatched sequences of DNA during replication and escape regulation. The operative goal of MMRs is the restoration of the parental genotype. One class of MMR in particular, MutSβ, is known to initiate the correction of insertion-deletion mismatches of up to 16 nucleotides. Little is known about the excision process in eukaryotes, but "E. coli" excisions involve the cleaving of a nick on either the 5' or 3' strand, after which DNA helicase and DNA polymerase III bind and generate single-stranded proteins, which are digested by exonucleases and attached to the strand by ligase. Multiple MMR pathways have been implicated in the maintenance of complex organism genome stability, and any of many possible malfunctions in the MMR pathway result in DNA editing and correction errors. Therefore, while it is not certain precisely what mechanisms lead to errors of non-homologous crossover, it is extremely likely that the MMR pathway is involved. | https://en.wikipedia.org/wiki?curid=64045 | 744,079 |
908,442 | Rutan made headlines again in June 2004 with SpaceShipOne, which became the first privately built, flown and funded manned craft to reach space. The project, named "Tier One" (later known as Tier 1b), was developed and flown by Mojave Aerospace Ventures, which is part-owned by Scaled Composites and was a joint venture between Paul Allen and Rutan, with an estimated development cost of US$25 million (provided entirely by Allen). On October 4, the SpaceShipOne team won the Ansari X Prize of US$10 million, completing two flights within two weeks, flying with the equivalent weight of 3 persons, and doing so while reusing at least 80% of the vehicle hardware. The two flights were piloted by Mike Melville and Brian Binnie respectively. The project team was honored with the 2004 Collier Trophy, awarded by the National Aeronautic Association for "greatest achievement in aeronautics or astronautics in America". The craft embodies Rutan's unique style, and is another of the "icons of flight" displayed in the NASM "Milestones of Flight" exhibit. As the first privately-funded spacecraft, it helped spur the beginning of the global private space race. | https://en.wikipedia.org/wiki?curid=422813 | 907,964 |
564,714 | "Ichthyornis" was one of the first Mesozoic avialans ever found and the first one known to have had teeth, making it an important discovery in the early history of paleontology. It remains important today, as it represents one of the closest non-avian relatives of modern birds, and one of a handful of Mesozoic bird relatives represented by numerous specimens. "Ichthyornis" was discovered in 1870 by Benjamin Franklin Mudge, a professor from Kansas State Agricultural College who recovered the initial fossils from the North Fork of the Solomon River in Kansas, United States. Mudge was a prolific fossil collector who shipped his discoveries to prominent scientists for study. Mudge had previously had a close partnership with paleontologist Edward Drinker Cope of the Academy of Natural Sciences in Philadelphia. However, as described by S.W. Williston in 1898, Mudge was soon contacted by Othniel Charles Marsh, Cope's rival in the so-called Bone Wars, a rush to collect and identify fossils in the American West. Marsh wrote to Mudge in 1872 and offered to identify any important fossils free of charge, and to give Mudge sole credit for their discovery. Marsh had been a friend of Mudge when they were younger, so when Mudge learned of Marsh's request, he changed the address on the shipping crate containing the "Ichthyornis" specimen (which had already been addressed to Cope and was ready to be sent), and shipped it to Marsh instead. Marsh had narrowly won the prestige of studying and naming the important fossil at the expense of his rival. | https://en.wikipedia.org/wiki?curid=1708899 | 564,424 |
2,218,488 | The site is located in the innermost part of Tanabe Bay facing the Kii Channel on the western shore of the Kii Peninsula. The area contains many sea caves caused by wave erosion, and the Isoma site is a rock shelter measuring about 23 meters wide by about 5 meters deep by 5 meters high on the west slope of a 20-meter hill made of soft sandstone. In 1969, a large amount of Sue ware pottery, antler products, and human bones, were excavated. The largest stone chamber contained the remains of an old man and an infant buried facing each other, and grave goods included many fishing implements, including fishing hooks and a harpoon and an iron sword. These remains were covered with the accumulation of fine sand due to the wind erosion of the rock shelter, but there was no evidence that there was a seal on the stone burial chamber, and the remains were originally exposed within the rock shelter. Within the shelter were a total of eight stone burial chambers with an estimated 13 human remains, and it is believed that they were used from the end of the 5th century to the first half of the 7th century AD, based on the contents of the grave goods. | https://en.wikipedia.org/wiki?curid=69429739 | 2,217,226 |
2,092,597 | Molecular Spectra and Molecular Structure IV. Constants of Diatomic Molecules, by K. P. Huber and Gerhard Herzberg (Van nostrand Reinhold company, New York, 1979, ), is a classic comprehensive multidisciplinary reference text contains a critical compilation of available data for all diatomic molecules and ions known at the time of publication - over 900 diatomic species in all - including electronic energies, vibrational and rotational constants, and observed transitions. Extensive footnotes discuss the reliability of these data and additional detailed informationon potential energy curves, spin-coupling constants, /\-type doubling, perturbations between electronic states, hyperfine structure, rotational g factors, dipole moments, radiative lifetimes, oscillator strengths, dissociation energies and ionization potentials when available, and other aspects. Herzberg received the 1971 Nobel Prize in Chemistry; both authors are world-renowned highly respected scientists. | https://en.wikipedia.org/wiki?curid=13182486 | 2,091,392 |
16,188 | The KGB's report, declassified in March 2003, dismissed various conspiracy theories and instead indicated the actions of airbase personnel contributed to the crash. The report states that an air-traffic controller provided Gagarin with outdated weather information and that by the time of his flight, conditions had deteriorated significantly. Ground crew also left external fuel tanks attached to the aircraft. Gagarin's planned flight activities needed clear weather and no outboard tanks. The investigation concluded Gagarin's aircraft entered a spin, either due to a bird strike or because of a sudden move to avoid another aircraft. Because of the out-of-date weather report, the crew believed their altitude was higher than it was and could not react properly to bring the MiG-15 out of its spin. Another theory, advanced in 2005 by the original crash investigator, hypothesizes that a cabin air vent was accidentally left open by the crew or the previous pilot, leading to oxygen deprivation and leaving the crew incapable of controlling the aircraft. A similar theory, published in "Air & Space" magazine, is that the crew detected the open vent and followed procedure by executing a rapid dive to a lower altitude. This dive caused them to lose consciousness and crash. | https://en.wikipedia.org/wiki?curid=34226 | 16,183 |
605,049 | Various application notes describe analysis in areas such as flavor and fragrance, food and beverage, packaging, pharmaceutical, cosmetic and perfumes, and chemical companies. More recently they can also address public concerns in terms of olfactive nuisance monitoring with networks of on-field devices. Since emission rates on a site can be extremely variable for some sources, the electronic nose can provide a tool to track fluctuations and trends and assess the situation in real time. It improves understanding of critical sources, leading to pro-active odor management. Real time modeling will present the current situation, allowing the operator to understand which periods and conditions are putting the facility at risk. Also, existing commercial systems can be programmed to have active alerts based on set points (odor concentration modeled at receptors/alert points or odor concentration at a nose/source) to initiate appropriate actions. | https://en.wikipedia.org/wiki?curid=8736181 | 604,739 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.