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The mutations in type XVIII collagen result in a multitude of abnormalities in vision and eye structure, some of which include high myopia, vitreoretinal degeneration, retinal detachment, macular abnormalities, and occipital encephalocele. Additionally, fragile iris, overgrowth of blood vessels in the retina, and an excess of electron-dense deposits, which leads to a disease called dense deposit disease, may also occur in Knobloch syndrome. Type XVIII collagen functions to provide strength, structural integrity, and cohesiveness to the basement membrane region in endothelial and epithelial cells of many different types of tissues. When type XVIII collagen is mutated at the COL18A1 gene, exon 2 in the sequence is skipped, which results in production of an early termination codon in exon 4 of this gene's transcript. This type of mutation particularly affects only one isoform of type XVIII collagen - the short isoform type, while the medium and long isoforms are unaffected.
https://en.wikipedia.org/wiki?curid=9932763
1,898,052
1,126,566
In these carbonate factories, precipitation is biotically controlled by heterotrophic organisms, sometimes in association with photo-autotrophic organisms such as red algae. The typical skeletal association includes foraminifers, red algae and molluscs. Despite being autotrophic, red algae are mostly associated to heterotrophic carbonate producers, and need less light than green algae. The range of occurrence of cool-water factories extends from the limit of the tropical factory (at about 30◦) up to polar latitudes, but they could also occur at low latitudes in the thermocline below the warm surface waters or in upwelling areas. This type of factories has a low potential of carbonate production, is largely independent from sunlight availability, and can sustain a higher amount of nutrients than tropical factories. Carbonate platforms built by the "cool-water factory" show two types of geometry or depositional profile, i.e., the homoclinal ramp or the distally-steepened ramp. In both geometries there are three parts: the inner ramp above the fair weather wave base, the middle ramp, above the storm wave base, the outer ramp, below the storm wave base. In distally steepened ramps, a distal step is formed between the middle and outer ramp, by the in situ accumulation of gravel-sized carbonate grains
https://en.wikipedia.org/wiki?curid=4327886
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The game industry requires innovations, as publishers cannot profit from constant release of repetitive sequels and imitations. Every year new independent development companies open and some manage to develop hit titles. Similarly, many developers close down because they cannot find a publishing contract or their production is not profitable. It is difficult to start a new company due to high initial investment required. Nevertheless, growth of casual and mobile game market has allowed developers with smaller teams to enter the market. Once the companies become financially stable, they may expand to develop larger games. Most developers start small and gradually expand their business. A developer receiving profit from a successful title may store up capital to expand and re-factor their company, as well as tolerate more failed deadlines.
https://en.wikipedia.org/wiki?curid=700265
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Patients living with the disorder into their adulthood often have trouble being involved in daily activities such as eating, walking, dressing, as well as performing everyday tasks. They are consistently faced with challenges that limit their ability to live on their own. They are more reluctant to be involved in social activities and romantic relationships and more likely to develop poor self-esteem and self-image related to their physical limitations as well as cognitive disabilities, though such habitual thinking is shown to decline when they feel they are accepted and supported by their peers. Patients are also inclined to associate themselves with people who tend not to be engaged in physical activities, according to the September 2008 issue of “Journal of Physical Activity and Health.”
https://en.wikipedia.org/wiki?curid=857160
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At the time that the Mk V was placed in production there were growing fears that the "Luftwaffe" were about to start mass-producing very high flying bombers such as the Junkers Ju 86, which could fly above the reach of most fighters of the time. It was decided that a new Spitfire variant would be required with improved high altitude performance. During a meeting held at the RAE at Farnborough on 17 February 1941 the Air Ministry asked "that a Spitfire should be provided with a pressure cabin capable of maintaining a pressure differential of at ." A Marshall-manufactured compressor was to be used, and it was agreed that the sliding canopy could be replaced by one which could not be slid open, as long as it could be jettisoned by the pilot.
https://en.wikipedia.org/wiki?curid=16070159
847,261
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The order Santalales, with its approximately 160 genera and 2,200 species distributed worldwide, is a monophyletic group that has long occupied an unresolved position at the base of the Gunneridae. Recently, phylogenetic studies based on molecular data from the complete chloroplast genome indicate a position of Santalales at the base of the Asterids. Santalales is ecologically diverse and includes free-living plants, such as "Erythropalum", as well as (hemi)parasites. Among the latter are species that parasitize stems or shoots, such as the mistletoes of the genus "Misodendrum", and root parasites, including the well-known and economically important sandalwood tree ("Santalum album"), whose aromatic wood is a component of many perfumes. The APG III classification system recognized seven families in Santalales: Balanophoraceae, Misodendraceae, Opiliaceae, Schoepfiaceae, Loranthaceae, Santalaceae (including Viscaceae), and Olacaceae. In 2010, however, new molecular data have made it possible to revise that conclusion, so that Aptandraceae, Balanophoraceae, Coulaceae, Erythropalaceae, Loranthaceae, Misodendraceae, Octonemaceae, Olacaceae, Opiliaceae, Santalaceae, Schoepfiaceae, Strombosiaceae, and Ximeniaceae are now recognized.
https://en.wikipedia.org/wiki?curid=53127579
2,121,667
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Synthetic colorants gained popularity as quickly with artists as with industry. The painters of the impressionist school in particular were famous early adopters. Critical reviews of Impressionists’ blues made comparisons to laundresses’ tubs, in particular the practice of laundry bluing, and to chemical waste dumped into the Seine by dye factories. One critic accused Edgar Degas, known for experiments in aquatint, pastel and oil painting as having an obsession with "chemistry," evoking a laboratory in description of his studio. Interestingly, Degas was known to be in correspondence with chemist Marcellin Berthelot, considered the father of organic synthetic chemistry in France. Pierre-Auguste Renoir’s later paintings relied heavily on alizarin crimson. He also employed cobalt blue or a mixture of ultramarine and cobalt blue, a synthetic pigment. New pigments and dyes were not limited to the artists of Europe, even Japanese printmakers were using dyes like rosaniline as early as 1863.
https://en.wikipedia.org/wiki?curid=62919428
1,786,750
1,904,288
There are two structurally unrelated proteins with this sort of activity, referred to as light-dependent (LPOR) and dark-operative (DPOR). The light- and NADPH-dependent reductase is part of the short-chain dehydrogenase/reductase (SDR) superfamily and is found in plants and oxygenic photosynthetic bacteria, while the ATP-dependent dark-operative version is a completely different protein, consisting of three subunits that exhibit significant sequence and quaternary structure similarity to the three subunits of nitrogenase. This enzyme may be evolutionary older; due to its bound iron-sulfur clusters is highly sensitive to free oxygen and does not function if the atmospheric oxygen concentration exceeds about 3%. It is possible that evolutionary pressure associated with the great oxidation event resulted in the development of the light-dependent system.
https://en.wikipedia.org/wiki?curid=14042084
1,903,194
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It is only recently that the concept of memes were set free from the narrow scope of merely hand-crafted local search heuristics, paving the path towards fully automated extraction, dispersal and exploitation of knowledge memes. In this era of data-democratization with access to modern computing platforms, emerges an unmanned multi-meme setting; one in which memes, capturing diverse forms of higher-order problem-solving knowledge, are uncovered by machines. They are thereafter made available for reuse across various problems. As such, making it possible for advanced optimizers to automatically harness the transmitted memes and orchestrate custom search behaviours on the fly without human intervention.
https://en.wikipedia.org/wiki?curid=60532440
2,090,266
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In Proposition 45 of his "Principia", Newton applies his theorem of revolving orbits to develop a method for finding the force laws that govern the motions of planets. Johannes Kepler had noted that the orbits of most planets and the Moon seemed to be ellipses, and the long axis of those ellipses can determined accurately from astronomical measurements. The long axis is defined as the line connecting the positions of minimum and maximum distances to the central point, i.e., the line connecting the two apses. For illustration, the long axis of the planet Mercury is defined as the line through its successive positions of perihelion and aphelion. Over time, the long axis of most orbiting bodies rotates gradually, generally no more than a few degrees per complete revolution, because of gravitational perturbations from other bodies, oblateness in the attracting body, general relativistic effects, and other effects. Newton's method uses this apsidal precession as a sensitive probe of the type of force being applied to the planets.
https://en.wikipedia.org/wiki?curid=12191272
1,146,194
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Subsequently he formed a new company, Gurian Instruments, which currently supplies materials and custom parts for the musical instrument, furniture and wood craft supply industries out of a floating facility in Seattle, Washington, although according to one video interview (see "External Links") he has not completely discounted the idea of returning to guitar making one day. As one of the "first wave" of independent luthiers working in the U.S.A. he mentored a number of younger makers in the field including Joe Veillette, Michael Millard and William R. Cumpiano of Froggy Bottom Guitars, Scott Hausmann, Thomas Humphrey and David Santo, as well as being a precursor to other "boutique" guitar making operations which followed such as Mossman, Santa Cruz, and Collings.
https://en.wikipedia.org/wiki?curid=50010272
2,114,647
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Hospital policies continued to change after the turn of the century. In 1801, Paris instated a new policy of hospital admission: a central office was created at Hotel Dieu that triaged all patients in Paris, and redirected them to the appropriate hospital for treatment. This triaging would account for the demand for medical education, and would often send patients to fill up learning hospitals such as the Charite. This centralization worked poorly, however. Prospective patients would often apply at nearby hospitals rather than make the journey to Hotel Dieu, and often physicians would select their own patients to fulfill needs of research or instruction rather than have the patients be assigned to them through triage. A similar centralization happened with pharmaceuticals: In 1795 a central pharmacy was created with rebuilt and adapted laboratories. This led to research in substitutes for substances such as cane sugar, opium, tea and coffee as well as the isolation of substances like caffeine and codeine. However, Napoleon seized the central pharmaceutical building in 1810, and it moved to a new facility in 1813.
https://en.wikipedia.org/wiki?curid=53106139
1,681,854
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The signing of the JCPOA in July 2015 by Hassan Rouhani and Javad Zarif with Barack Obama heralded a new era of détente in foreign relations. With it, Iran was allowed to come in from the cold, as it were and once again to sell its oil unencumbered on the world stage. The withdrawal by Donald Trump from the JCPOA in May 2018 was an ill wind for Iran because he decided to re-apply the sanctions regime that had caused such difficulties to Khamenei. For example, the was captured near Gibraltar in July 2019 at the request of the US by the armed forces of the UK. The incident was one of several that have been labelled as the 2019 Persian Gulf crisis, but the crisis soon widened to encompass more distant seas where Iranian arms are impotent. In May the Iranian tanker "Happiness 1" suffered difficulties near Jiddah. In August the tanker "Helm" encountered difficulties while transiting the Red Sea, and in October the Iranian tanker "Sabiti" was attacked by two missiles of unknown origin, again in the Red Sea. The fully laden "Sabiti" had been destined for the "Eastern Mediterranean".
https://en.wikipedia.org/wiki?curid=28205267
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The cultural practices of the United States show considerable similarities to those in northern and central European regions, such as Germany, Scandinavia, and the United Kingdom. Greeting rituals tend to be the same in Europe and in the United States, consisting of minimal body contact—often confined to a simple handshake. The main cultural difference in proxemics is that residents of the United States like to keep more open space between themselves and their conversation partners (roughly compared to in Europe). European cultural history has seen a change in personal space since Roman times, along with the boundaries of public and private space. This topic has been explored in "A History of Private Life" (2001), under the general editorship of Philippe Ariès and Georges Duby. On the other hand, those living in densely populated places likely have lower expectations of personal space. Residents of India or Japan tend to have a smaller personal space than those in the Mongolian steppe, both in regard to home and individual spaces. Different expectations of personal space can lead to difficulties in intercultural communication.
https://en.wikipedia.org/wiki?curid=225761
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A Witt lecture on the poor processes used by the American naval stores industry and the almost certain likelihood that those processes would completely destroy the Longleaf Pine ("Pinus palustris") led Herty to study the naval store industry's use of those trees to produce timber and turpentine. After engaging in literature and field research to better understand the industry and its processes, Herty confirmed the validity of Witt's claim that the pine species would be completely destroyed. Herty also elucidated massive inefficiencies in the destructive collection processes. After conferring with forester W. W. Ashe of the North Carolina Geological Survey, Herty simplified a cup and gutter system used for many decades in France to combat both problems. The "Herty system" required less forestry expertise and labor, both necessities to ensure the method's financial success in the United States.
https://en.wikipedia.org/wiki?curid=8435062
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In Klazomenai primarily amphoras and hydria were painted in the middle of the 6th century BC (c. 550 to 350 BC), as well as deep bowls with flat, angular-looking figures. The vessels are not very elegant in workmanship. Dancing women and animals were frequently depicted. Leading workshops were those of the Tübingen Painter, the Petrie Painter, and the Urla Group. Most of the vases were found in Naukratis and in Tell Defenneh, which was abandoned in 525 BC. Their origin was initially uncertain, but Robert Zahn identified the source by comparison with images on Klazomenian sarcophagi. The pottery was often decorated with sculptured women's masks. Mythological scenes were rare; fishscale ornaments, rows of white dots, and stiff-looking dancing women were popular. The depiction of a herold standing in front of a king and a queen is unique. In general, men were characterized by large, spade-shaped beards. Starting already in 600 BC and continuing to about 520 BC rosette cups, successor to the eastern Greece bird cups, were produced, probably in Klazomenai.
https://en.wikipedia.org/wiki?curid=1076046
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Under most viewing conditions, the Andromeda Galaxy is one of the most distant objects that can be seen with the naked eye (M33 and M81 can be seen under very dark skies). The galaxy is commonly located in the sky about the constellations Cassiopeia and Pegasus. Andromeda is best seen during autumn nights in the Northern Hemisphere when it passes high overhead, reaching its highest point around midnight in October, and two hours earlier each successive month. In the early evening, it rises in the east in September and sets in the west in February. From the Southern Hemisphere the Andromeda Galaxy is visible between October and December, best viewed from as far north as possible. Binoculars can reveal some larger structures of the galaxy and its two brightest satellite galaxies, M32 and M110. An amateur telescope can reveal Andromeda's disk, some of its brightest globular clusters, dark dust lanes, and the large star cloud NGC 206.
https://en.wikipedia.org/wiki?curid=74331
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There are other forms of preventive actions, an example for Hereditary Breast and Ovarian Cancer would be to go through surgery: A hysterectomy is the removal of all or some of the uterus, whereas a mastectomy is removing a breast (double mastectomy meaning that both breasts are removed), this can often add years onto their life expectancy. Another preventive measure is regular cancer screening and check-ups. If a person has Lynch's syndrome then they should have a regular colonoscopy to examine if there is any change in the cells lining the intestinal wall, regular check-ups are associated with an additional 7 years onto the life expectancy on average for a person with Lynch's syndrome. This is because early detection means the correct preventive actions and surgery can be taken quicker. Regular breast screening is also recommended for women diagnosed with BRCA mutations, as well as that, recent studies show that men with increased risks of developing prostate cancer due to BRCA mutations can decrease their risk by taking aspirin. Aspirin is hugely beneficial in lowering cancer prevalence; however, it must be taken regularly over at least a five-year period to have any effect.
https://en.wikipedia.org/wiki?curid=38885064
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Imahara began his career at Lucasfilm, where he worked in the THX division as an engineer and in the Industrial Light & Magic division in visual effects. His work has been featured in films from franchises such as "Star Wars", "Jurassic Park", "The Matrix", and "Terminator". His first foray into television was on the robot combat series "BattleBots", for which he designed and competed with his robot Deadblow and later returned as a judge. Imahara was also a chief model maker with Industrial Light & Magic (ILM) on such movie projects as "Galaxy Quest". In 2005, Imahara joined the cast of "Mythbusters" as a member of the Build Team, appearing in over 200 episodes of the series until his departure in 2014. In 2010, he designed the animatronic "robot skeleton" Geoff Peterson to serve as a sidekick on "The Late Late Show with Craig Ferguson". He starred in the 2016 Netflix series "White Rabbit Project" alongside his "MythBusters" co-stars Kari Byron and Tory Belleci.
https://en.wikipedia.org/wiki?curid=4040762
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Nowadays, data management has transferred over from local storage to the cloud. In the late 1990s and early 2000s, Salesforce and Amazon popularized the concept of internet-based services, which appealed to customers as it reduced in-house maintenance costs and increased flexibility in changing the needs of a business. With the rising prevalence of artificial intelligence (AI), it is now easier than ever to store and sort through immense sets of data. It is in this era that DMPs have experienced their rise to prominence as the astronomical amount of user data in the world can now be processed and presented to companies for marketing purposes.
https://en.wikipedia.org/wiki?curid=57391332
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In 2009, Riazuddin published a mathematical theory of the non-standard model, and its brief extensions to τ (tau) particles – particles that are similar to electrons with negative electric charge. In an experiment performed at the Synchrotron light source installed at the National Center for Physics (NCP), now the Abdus Salam Centre for Physics, Riazuddin observed the decay of the Tau particle, in which he theorised that hadronisation vector currents and axial vectors can be used to study the implicit properties and functions of hadronic resonances, together with Chiral symmetry. These natural elements can be assigned to the parts' weak current that the strong nuclear interaction conserves. With the introduction of such elementary particles, it became critical to study the particle elements that hold the weak interaction.
https://en.wikipedia.org/wiki?curid=22233947
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Research published in the March 26, 2009 issue of the journal "Nature", describes how scientists were able to identify an asteroid in space before it entered Earth's atmosphere, enabling computers to determine its area of origin in the Solar System as well as predict the arrival time and location on Earth of its shattered surviving parts. The four-meter-diameter asteroid, called 2008 TC, was initially sighted by the automated Catalina Sky Survey telescope, on October 6, 2008. Computations correctly predicted that it would impact 19 hours after discovery and in the Nubian Desert of northern Sudan.
https://en.wikipedia.org/wiki?curid=174069
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Water makes an excellent moderator; the ordinary hydrogen or "protium" atoms in the water molecules are very close in mass to a single neutron, and so their collisions result in a very efficient transfer of momentum, similar conceptually to the collision of two billiard balls. However, as well as being a good moderator, ordinary water is also quite effective at absorbing neutrons. And so using ordinary water as a moderator will easily absorb so many neutrons that too few are left to sustain a chain reaction with the small isolated U nuclei in the fuel, thus precluding criticality in natural uranium. Because of this, a light-water reactor will require that the U isotope be concentrated in its uranium fuel, as enriched uranium, generally between 3% to 5% U by weight (the by-product from this process enrichment process is known as depleted uranium, and so consisting mainly of U, chemically pure). The degree of enrichment needed to achieve "criticality" with a "light-water" moderator depends on the exact geometry and other design parameters of the reactor.
https://en.wikipedia.org/wiki?curid=33087778
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CIP theory is based on cognitive therapy concepts developed by Aaron Beck, which specify that dysfunctional cognitions have a detrimental impact on behavior and emotions. Through cognitive restructuring, collaborative empiricism, attention to emotions, and the development of an effective helping relationship, clients learn to replace dysfunctional cognitions with functional cognitions, resulting in positive changes in behavior and emotions. Dysfunctional cognitions have been determined to interfere with the different components of the CIP approach (self-knowledge, options knowledge, communication, analysis, synthesis, valuing, execution, and executive processing); and the assumptions, attitudes, behaviors, beliefs, feelings, plans, and/or strategies related to career problem solving and decision making must be considered when providing career counseling services.
https://en.wikipedia.org/wiki?curid=29303703
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Individual action on climate change can include personal choices in many areas, such as diet, travel, household energy use, consumption of goods and services, and family size. People who wish to reduce their carbon footprint (particularly those in high income countries with high consumption lifestyles), can take "high-impact" actions, such as avoiding frequent flying and petrol fuelled cars, eating mainly a plant-based diet, having fewer children, using clothes and electrical products for longer, and electrifying homes. Excessive consumption is more to blame for climate change than population increase. High consumption lifestyles have a greater environmental impact, with the richest 10% of people emitting about half the total lifestyle emissions.
https://en.wikipedia.org/wiki?curid=2119179
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A breakthrough came in the summer of 1895, when Marconi found that much greater range could be achieved after he raised the height of his antenna and, borrowing from a technique used in wired telegraphy, grounded his transmitter and receiver. With these improvements, the system was capable of transmitting signals up to and over hills. The monopole antenna reduced the frequency of the waves compared to the dipole antennas used by Hertz, and radiated vertically polarized radio waves which could travel longer distances. By this point, he concluded that a device could become capable of spanning greater distances, with additional funding and research, and would prove valuable both commercially and militarily. Marconi's experimental apparatus proved to be the first engineering-complete, commercially successful radio transmission system.
https://en.wikipedia.org/wiki?curid=12104
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The greatest OSH benefits stemming from the wider use of robotics should be substitution for people working in unhealthy or dangerous environments. In space, defense, security, or the nuclear industry, but also in logistics, maintenance, and inspection, autonomous robots are particularly useful in replacing human workers performing dirty, dull or unsafe tasks, thus avoiding workers' exposures to hazardous agents and conditions and reducing physical, ergonomic and psychosocial risks. For example, robots are already used to perform repetitive and monotonous tasks, to handle radioactive material or to work in explosive atmospheres. In the future, many other highly repetitive, risky or unpleasant tasks will be performed by robots in a variety of sectors like agriculture, construction, transport, healthcare, firefighting or cleaning services.
https://en.wikipedia.org/wiki?curid=20903754
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Besides the strength and duration of "E"("t"), the THz field's photon energy plays a vital role in semiconductor investigations because it can be made resonant with several intriguing many-body transitions. For example, electrons in conduction band and holes, i.e., electronic vacancies, in valence band attract each other via the Coulomb interaction. Under suitable conditions, electrons and holes can be bound to excitons that are hydrogen-like states of matter. At the same time, the exciton binding energy is few to hundreds of meV that can be matched energetically with a THz photon. Therefore, the presence of excitons can be uniquely detected based on the absorption spectrum of a weak THz field. Also simple states, such as plasma and correlated electron–hole plasma can be monitored or modified by THz fields.
https://en.wikipedia.org/wiki?curid=39456566
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After extensive negotiations and technical information exchanges between the U.S. and Russian space teams, the Russians concluded close approach could be safely achieved and the STS-63 crew was given 'go' to proceed. R1U's thruster manifold was closed and the backup thruster was selected for the approach. Ship-to-ship radio contact with "Mir" was achieved well ahead of time, and Titov, who had previously lived on "Mir" for more than a year, communicated excitedly with the three cosmonauts aboard the space station: Mir 17 Commander Alexander Viktorenko; Flight Engineer Yelena Kondakova; and Valery Polyakov, a physician who had broken Titov's record for extended time in space. After stationkeeping at a distance of from "Mir" and with Wetherbee manually controlling the orbiter, "Discovery" was flown to from the Russian space station. "As we are bringing our spaceships closer together, we are bringing our nations closer together," Wetherbee said after "Discovery" was at point of closest approach. "The next time we approach, we will shake your hand and together we will lead our world into the next millennium." The closest approach to "Mir" of occurred on 6 February 1995 at 19:23:20 UTC.
https://en.wikipedia.org/wiki?curid=526864
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Mangrove restoration is the regeneration of mangrove forest ecosystems in areas where they have previously existed. The practice of mangrove restoration is grounded in the discipline of restoration ecology, which aims to “[assist] the recovery of resilience and adaptive capacity of ecosystems that have been degraded, damaged, or destroyed”. Since environmental impacts are an ongoing threat, to successfully restore an ecosystem implies not merely to recreate its former condition, but to strengthen its capacity to adapt to change over time. Mangrove forests are most likely to thrive in the upper half of the intertidal zone. If planted below the mean tide level, or subject to too great a sea level rise, they may fail to thrive. Success will also depend on the species chosen and their suitability to conditions.
https://en.wikipedia.org/wiki?curid=36309813
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Webster was born in Orkney in 1772, probably at Kirkwall, and was educated at Aberdeen. He subsequently went to London and studied architecture, the Royal Institution in Albemarle Street being built from his design, and where in 1830 he delivered the Royal Institution Christmas Lecture. In 1826 he was appointed house-secretary and curator to the Geological Society of London, and for many years he rendered important services in editing and illustrating the "Transactions" of the Society. In 1841–42 he was professor of geology in University College, London. He was an accomplished water-colour painter and was elected an honorary member of the Sketch Society. He contributed articles about Architecture and Aquatinta to "Rees's Cyclopædia". "An Encyclopaedia of Domestic Economy", a comprehensive guide to running a household which Webster had compiled with the help of a Mrs. Parkes, was published after his death in 1844.
https://en.wikipedia.org/wiki?curid=2162541
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The regular representation of a group ring is such that the left-hand and right-hand regular representations give isomorphic modules (and we often need not distinguish the cases). Given an algebra over a field "A", it doesn't immediately make sense to ask about the relation between "A" as left-module over itself, and as right-module. In the group case, the mapping on basis elements "g" of "K"["G"] defined by taking the inverse element gives an isomorphism of "K"["G"] to its "opposite" ring. For "A" general, such a structure is called a Frobenius algebra. As the name implies, these were introduced by Frobenius in the nineteenth century. They have been shown to be related to topological quantum field theory in 1 + 1 dimensions by a particular instance of the cobordism hypothesis.
https://en.wikipedia.org/wiki?curid=360011
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Due to Santaolalla's stance on composing music—he lacks knowledge in reading and writing sheet music, preferring to simply record—he began working on "The Last of Us" early in development. To give Santaolalla a point to base his music, Druckmann simply told him about the story and themes, as opposed to giving specific instructions on composing; Santaolalla appreciated this freedom, feeling it assisted in the composing. To compose, Santaolalla felt the need to "go into some more dark place, more textural and not necessarily melodic". To challenge himself, Santaolalla used a variety of unique instruments he was unfamiliar with, giving a sense of danger and innocence. For "The Last of Us", he used a detuned guitar, producing deep noise. To produce unique tunes, Santaolalla recorded in various rooms, including a bathroom and kitchen. The team wanted the game's AI to affect the music. They also tried to make the music evoke a reaction from the player, as their familiarization with the sounds would trigger a previous emotion that they felt. Music manager Jonathan Mayer felt that the game's action music was atypical of action music in other games, stating that it's "relatively low-key", and that taking it out of context changes the immediate reaction to it. The game's theme, "The Last of Us", was the first piece of music that the team received, and they were very impressed.
https://en.wikipedia.org/wiki?curid=45204814
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Lestaurtinib was mentioned as one of two oncology drugs being developed by Cephalon in a 2007 U.S. Securities and Exchange Commission (SEC) report. According to this report, in addition to holding patent applications involving methods of treatment, formulations, and polymorphs of lestaurtinib, Cephalon held a composition of matter patent for lestaurtinib in the United States that would expire in 2008. In 2006, the U.S. FDA granted lestaurtinib orphan drug status for the treatment of AML, reflecting the significant need but minimal market for treatment of AML. In the wake of preliminary failing results for the Phase III clinical trial involving Lestaurtinib, Cephalon founder and CEO Frank Baldino, Ph.D., issued the following statement in 2009:
https://en.wikipedia.org/wiki?curid=16764111
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Quasi-experimental estimates of impact are subject to contamination by confounding variables. In the example above, a variation in the children's response to spanking is plausibly influenced by factors that cannot be easily measured and controlled, for example the child's intrinsic wildness or the parent's irritability. The lack of random assignment in the quasi-experimental design method may allow studies to be more feasible, but this also poses many challenges for the investigator in terms of internal validity. This deficiency in randomization makes it harder to rule out confounding variables and introduces new threats to internal validity. Because randomization is absent, some knowledge about the data can be approximated, but conclusions of causal relationships are difficult to determine due to a variety of extraneous and confounding variables that exist in a social environment. Moreover, even if these threats to internal validity are assessed, causation still cannot be fully established because the experimenter does not have total control over extraneous variables.
https://en.wikipedia.org/wiki?curid=11864322
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In 1898, Foster found work teaching chemistry at Lynn High and Classical School. The next year, she became an assistant researcher in the Lab of Physiology and Chemistry in New York, where she stayed until 1901. In 1903, Foster worked as a research chemist in the department of pharmacology at Columbia University, where she stayed on until 1907. Concurrent with her research, she was also a professor in the chemistry department at the Woman's Medical College of New York (1904-1905). After working at Columbia University, Foster was appointed as an instructor and later associate professor at Smith College, where she played a major role in introducing the field of biochemistry to the curriculum. She offered the first biochemistry course during 1916-17, and with the exception of the semesters she was on sabbatical leave, taught this and other biochemistry courses until her retirement in 1933.
https://en.wikipedia.org/wiki?curid=46432429
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The 2012 College Football All-America Team includes those players of American college football who have been honored by various selector organizations as the best players at their respective positions. The selector organizations award the "All-America" honor annually following the conclusion of the fall college football season. The original All-America team was the 1889 College Football All-America Team selected by Caspar Whitney and Walter Camp. In 1950, the National Collegiate Athletic Bureau, which is the National Collegiate Athletic Association's (NCAA) service bureau, compiled the first list of All-Americans including first-team selections on teams created for a national audience that received national circulation with the intent of recognizing selections made from viewpoints that were nationwide. Since 1952, College Sports Information Directors of America (CoSIDA) has bestowed Academic All-American recognition on male and female athletes in Divisions I, II, and III of the NCAA as well as National Association of Intercollegiate Athletics athletes, covering all NCAA championship sports.
https://en.wikipedia.org/wiki?curid=37795583
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Five main groups of lepospondyls are often recognized: Microsauria, a superficially lizard- or salamander-like and species-rich group; Lysorophia, a group with elongated bodies and very small limbs; Aïstopoda, a group of limbless, extremely elongated snake-like forms; Adelospondyli, a group of presumably aquatic forms that resemble aïstopods, but have more solidly built skulls; and Nectridea, another diverse group that includes terrestrial and aquatic newt-like forms. Microsauria is generally considered paraphyletic; rather than being a monophyletic group, it has been considered an evolutionary grade of basal ("primitive") lepospondyls, although there is growing consensus that a large subset of fossorially-adapted microsaurs, the Recumbirostra, is monophyletic. Lysorophia may belong within the Recumbirostran clade, distinct from other derived lepospondyls. Nectridea may also be paraphyletic, consisting of a range of more anatomically-specialized lepospondyls. The name Holospondyli has been proposed for a clade including aïstopods, and nectrideans, and possibly adelospondyls, although not all recent phylogenetic analyses support the grouping. The following cladogram, simplified, is after an analysis of tetrapods and stem-tetrapods presented by Ruta "et al." in 2003:
https://en.wikipedia.org/wiki?curid=1908699
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Spinosyn A does not appear to interact directly with known insecticidal-relevant target sites, but rather acts via a novel mechanism. Spinosyn A resembles a GABA antagonist and is comparable to the effect of avermectin on insect neurons. Spinosyn A is highly active against neonate larvae of the tobacco budworm, "Heliothis virescens", and is slightly more biologically active than spinosyn D. In general, spinosyns possessing a methyl group at C6 (spinosyn D-related analogs) tend to be more active and less affected by changes in the rest of the molecule. Spinosyn A is slow to penetrate to the internal fluids of larvae; it is also poorly metabolized once it enters the insect. The apparent lack of spinosyn A metabolism may contribute to its high level of activity, and may compensate for the slow rate of penetration.
https://en.wikipedia.org/wiki?curid=10831708
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Taking a similar approach, a unique global study of 1,409 children undergoing emergency laparotomy from 253 centres in 43 countries showed that adjusted mortality in children following surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries, translating to 40 excess deaths per 1,000 procedures performed in these settings. Internationally, the most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23)) and middle-HDI (4.42 (1.44 to 13.56)) countries compared with high-HDI countries.
https://en.wikipedia.org/wiki?curid=1303
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President Bill Clinton exercised his line-item veto power at the time, however, and eliminated the Congressionally approved $39 million allocated to the SR-71 program in the fiscal year (FY) 1998 budget. Detachment 2 immediately ceased operations. The United States Supreme Court later declared presidential line-item veto authority unconstitutional. The future of the SR-71 program remained uncertain. Congress did not include funding for the program in its FY 1999 budget. On 7 April 1998, Air Combat Command received a message from the Office of the Secretary of the Air Force ordering cessation of SR-71 operations and disposal of all related assets. The last member of Detachment 2 left Edwards AFB, CA on 10 January 1999. Upon transfer of the two remaining airframes to Air Force Materiel Command, Air Combat Command declared the SR-71 retirement complete as of 15 July 1999. Air Combat Command inactivated Detachment 2, 9th Operations Group, Edwards AFB, CA on 1 August 1999.
https://en.wikipedia.org/wiki?curid=8294433
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Semi circular ducts, which are connected directly to the cochlea, can interpret and convey to the brain information about equilibrium by a similar method as the one used for hearing. Hair cells in these parts of the ear protrude kinocilia and stereocilia into a gelatinous material that lines the ducts of this canal. In parts of these semi circular canals, specifically the maculae, calcium carbonate crystals known as statoconia rest on the surface of this gelatinous material. When tilting the head or when the body undergoes linear acceleration, these crystals move disturbing the cilia of the hair cells and, consequently, affecting the release of neurotransmitter to be taken up by surrounding sensory nerves. In other areas of the semi circular canal, specifically the ampulla, a structure known as the cupula—analogous to the gelatinous material in the maculae—distorts hair cells in a similar fashion when the fluid medium that surrounds it causes the cupula itself to move. The ampulla communicates to the brain information about the head's horizontal rotation. Neurons of the adjacent vestibular ganglia monitor the hair cells in these ducts. These sensory fibers form the vestibular branch of the cranial nerve VIII.
https://en.wikipedia.org/wiki?curid=569399
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Boeing has invested in a blended wing body airplane program since 1993, a program which Liebeck managed. Run through Boeing's Phantom Works division, the program researched, designed and prototyped new aircraft designs which would reduce energy consumption and noise production. Initially funded by a grant from NASA of $90,000, the aircraft design moves away from the usual tube-and-wing design and instead has the wings blended into the body. This design was developed by Liebeck, in conjunction with other members of the research team. Liebeck's team released a remote-driven model, the X-48, in 1997, flight tested a three-engine version, the X-48B, in 2008-9 and a two-engine version, the X-48C in 2013.
https://en.wikipedia.org/wiki?curid=41891348
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The first known mill in Lancashire dedicated to ring spinning was built in Milnrow for the New Ladyhouse Cotton Spinning Company (registered 26 April 1877). A cluster of smaller mills developed which between 1884 and 1914 out performed the ring mills of Oldham. After 1926, the Lancashire industry went into sharp decline, the Indian export market was lost, Japan was self-sufficient. Textile firms united to reduce capacity rather than to add to it. It wasn't until the late 1940s that some replacement spindles started to be ordered and ring frames became dominant. Debate still continues in academic papers on whether the Lancashire entrepreneurs made the right purchases decisions in the 1890s. The engine house and steam engine of the Ellenroad Ring Mill are preserved.
https://en.wikipedia.org/wiki?curid=22591478
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In 2018, Willerslev and colleges published 2 papers in Nature and Science the same day addressing the population history of Central and Southern Asia. The Science paper deals with the spread of the Bronze Age pastoralists, such as Yamnaya and the peoples they met in Asia. They could show that descendants of the 24-thousand-year-old Maltá boy from Siberia survived in Central Asia until at least 5 thousand years ago and were the occupants of Botai – an archaeological site in Kazakhstan holding the oldest evidence of horse domestication some 5-6 thousand years ago. They further showed that in contrast to Europe, early Bronze Age expansion of Yamnaya into Asia had limited genetic and linguistic impact in either Central Asia or in South Asia, contrary to earlier claims by the Reich group from Harvard. The paper thereby challenges the so-called “Steppe Hypothesis” for early spread of the Indo-European languages that seem to explain the early expansion of Indo-European languages into Europe but not Asia. The latter is argued to have happened by later Bronze groups, such as the Sintashta, and reaching all the way to India and Pakistan.
https://en.wikipedia.org/wiki?curid=19136941
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Palmer would learn of those behind the genocide of the Morlaidhans, namely five CIA operatives, part of a group called the Cabal. In a mission called Operation: Fireball, the tiny aliens were murdered in hopes Ray would return as the Atom and become a tool for the Cabal (as Ray worked for the CIA in his earlier years). Instead, Palmer shrank the five agents to six-inch height and the CIA would employ them as a group called Micro/Squad. The Atom would take on new enemies during this period, such as Humbug, a sentient robot in control of an army of duplicates of itself, and Strobe, a technological armor-clad crook. Micro/Squad would also return, attempting to murder Palmer for what he did to them. Instead, teammate Ginsburg dies in the explosion they set and Ray approaches Adam Cray about becoming the new Atom to bring the remaining Micro/Squad into the open. Cray agrees, steals Paul Hoben's size-changing belt, and joins the Suicide Squad. The plan works as the villains emerge and Palmer takes the place of operative Sting; but their leader, Blacksnake, kills Cray and takes the belt for himself, returning to normal height. Blacksnake murders the remaining members of his crew as Ray arrives, revealing himself, posing as Sting, and battles him. After Blacksnake is defeated, the Cabal employs Task Force X II to murder him to protect their secrets.
https://en.wikipedia.org/wiki?curid=4971776
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'Model' helicopters can be dangerous. Safety precautions, proper maintenance, and an understanding of the mechanics and flight characteristics of the models are necessary to prevent accidents. Modelers who fly at sanctioned sites are required to follow safety rules designated by national model aircraft organizations. In the United States, the Academy of Model Aeronautics (AMA) publishes and updates safety rules for all model aircraft operations, including fixed and rotary wing models. In 2014, several organizations with interest in unmanned aircraft systems in partnership with the Federal Aviation Administration launched a new educational campaign to promote safe and responsible flying and provide guidance for hobbyists and commercial users.
https://en.wikipedia.org/wiki?curid=2334889
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The 3D structure of "Brassica rapa" (Turnip) cyt f has been determined. The lumen-side segment of cyt f includes two structural domains: a small one above a larger one that, in turn, is on top of the attachment to the membrane domain. The large domain consists of an anti-parallel beta-sandwich and a short haem-binding peptide, which form a three-layer structure. The small domain is inserted between beta-strands F and G of the large domain and is an all-beta domain. The haem nestles between two short helices at the N terminus of cyt f. Within the second helix is the sequence motif for the c-type cytochromes, CxxCH (residues 21–25), which is covalently attached to the haem through thioether bonds to Cys-21 and Cys-24. His-25 is the fifth haem iron ligand. The sixth haem iron ligand is the alpha-amino group of Tyr-1 in the first helix. Cyt f has an internal network of water molecules that may function as a proton wire. The water chain appears to be a conserved feature of cyt f.
https://en.wikipedia.org/wiki?curid=2001549
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High-field high-frequency EPR measurements are sometimes needed to detect subtle spectroscopic details. However, for many years the use of electromagnets to produce the needed fields above 1.5 T was impossible, due principally to limitations of traditional magnet materials. The first multifunctional millimeter EPR spectrometer with a superconducting solenoid was described in the early 1970s by Prof. Y. S. Lebedev's group (Russian Institute of Chemical Physics, Moscow) in collaboration with L. G. Oranski's group (Ukrainian Physics and Technics Institute, Donetsk), which began working in the Institute of Problems of Chemical Physics, Chernogolovka around 1975. Two decades later, a W-band EPR spectrometer was produced as a small commercial line by the German Bruker Company, initiating the expansion of W-band EPR techniques into medium-sized academic laboratories.
https://en.wikipedia.org/wiki?curid=1926015
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Experiments conducted in the 1970s also studied the phenomenon. These experiments revealed that although several explanations for why the LF were observed by astronauts have been proposed, there may be other causes as well. Charman "et al." (1971) asked whether the LF were the result of single cosmic-ray nuclei entering the eye and directly exciting the eyes of the astronauts, as opposed to the result of Cherenkov radiation within the retina. The researchers had observers view a neutron beam, composed of either 3 or 14 MeV monoenergetic neutrons, in several orientations, relative to their heads. The composition of these beams ensured that particles generated in the eye were below 500 MeV, which was considered the Cherenkov threshold, thereby allowing the researchers to separate one cause of the LF from the other. Observers viewed the neutron beam after being completely dark-adapted.
https://en.wikipedia.org/wiki?curid=1364633
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A colloidal crystal is a highly ordered array of particles that can be formed over a very long range (typically on the order of a few millimeters to one centimeter) and that appear analogous to their atomic or molecular counterparts. One of the finest natural examples of this ordering phenomenon can be found in precious opal, in which brilliant regions of pure spectral color result from close-packed domains of amorphous colloidal spheres of silicon dioxide (or silica, SiO). These spherical particles precipitate in highly siliceous pools in Australia and elsewhere, and form these highly ordered arrays after years of sedimentation and compression under hydrostatic and gravitational forces. The periodic arrays of submicrometre spherical particles provide similar arrays of interstitial voids, which act as a natural diffraction grating for visible light waves, particularly when the interstitial spacing is of the same order of magnitude as the incident lightwave.
https://en.wikipedia.org/wiki?curid=5346
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Partial classifications exist for many individual groups of organisms and are revised and replaced as new information becomes available; however, comprehensive, published treatments of most or all life are rarer; recent examples are that of Adl et al., 2012 and 2019, which covers eukaryotes only with an emphasis on protists, and Ruggiero et al., 2015, covering both eukaryotes and prokaryotes to the rank of Order, although both exclude fossil representatives. A separate compilation (Ruggiero, 2014) covers extant taxa to the rank of Family. Other, database-driven treatments include the Encyclopedia of Life, the Global Biodiversity Information Facility, the NCBI taxonomy database, the Interim Register of Marine and Nonmarine Genera, the Open Tree of Life, and the Catalogue of Life. The Paleobiology Database is a resource for fossils.
https://en.wikipedia.org/wiki?curid=30463
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The number 42 is, in "The Hitchhiker's Guide to the Galaxy" by Douglas Adams, the "Answer to the Ultimate Question of Life, the Universe, and Everything," calculated by an enormous supercomputer named Deep Thought over a period of 7.5 million years. Unfortunately, no one knows what the question is. Thus, to calculate the Ultimate Question, a special computer the size of a small planet was built from organic components and named "Earth". The Ultimate Question "What do you get when you multiply six by nine" was found by Arthur Dent and Ford Prefect in the second book of the series, "The Restaurant at the End of the Universe". This appeared first in the radio play and later in the novelization of "The Hitchhiker's Guide to the Galaxy". The fact that Adams named the episodes of the radio play "fits", the same archaic title for a chapter or section used by Lewis Carroll in "The Hunting of the Snark", suggests that Adams was influenced by Carroll's fascination with and frequent use of the number. The fourth book in the series, , contains 42 chapters. According to , 42 is the street address of Stavromula Beta. In 1994, Adams created the "42 Puzzle", a game based on the number 42.
https://en.wikipedia.org/wiki?curid=191178
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Part four considers conquest. Why is it that the Eurasians came to dominate other cultures? Diamond's answer is that, in part, this was due to the East–West layout of the Eurasian continent, due to which successful agricultural and animal domestication packages (combinations of certain domesticated plants and animals) could easily be adopted in regions farther east or west. On the other hand, extension of domestication packages along the North–South axis – as required in the case of the American and African continents – was much more difficult owing to severe imbalances of climate. Also, long-lasting contact with domesticated animals of agricultural populations permits greater resistance to disease, which is another reason why contact among geographically separated cultures – mostly agricultural versus hunter-gatherer societies – often leads to extinction of the latter through devastating infections.
https://en.wikipedia.org/wiki?curid=2521255
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The men's eight competition at the 1932 Summer Olympics in Los Angeles took place at the Long Beach Marine Stadium. It was held from 10 to 13 August. There were 8 boats (72 competitors) from 8 nations, with each nation limited to a single boat in the event. The event was won by the United States, the nation's fourth consecutive and sixth overall victory; the Americans had won every time they competed (missing 1908 and 1912). Silver went to Italy, that nation's second medal in the men's eight after a bronze in 1924. Canada repeated as bronze medalists, stretching their podium streak in the event to three Games.
https://en.wikipedia.org/wiki?curid=38224230
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Broca published his findings from the autopsies of the twelve patients in his paper "Localization of Speech in the Third Left Frontal Cultivation" in 1865. His work inspired others to perform careful autopsies with the aim of linking more brain regions to sensory and motor functions. Although history credits this discovery to Broca, another French neurologist, Marc Dax, had made similar observations a generation earlier. Based on his work with approximately forty patients and subjects from other papers, Dax presented his findings at an 1836 conference of southern France physicians in Montpellier. Dax died soon after this presentation and it was not reported or published until after Broca made his initial findings. Accordingly, Dax's and Broca's conclusions that the left frontal lobe is essential for producing language are considered to be independent.
https://en.wikipedia.org/wiki?curid=145048
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Two-dimensional fire growth models such as FARSITE and Prometheus, the Canadian wildland fire growth model designed to work in Canadian fuel complexes, have been developed that apply such semi-empirical relationships and others regarding ground-to-crown transitions to calculate fire spread and other parameters along the surface. Certain assumptions must be made in models such as FARSITE and Prometheus to shape the fire growth. For example, Prometheus and FARSITE use the Huygens principle of wave propagation. A set of equations that can be used to propagate (shape and direction) a fire front using an elliptical shape was developed by Richards in 1990. Although more sophisticated applications use a three-dimensional numerical weather prediction system to provide inputs such as wind velocity to one of the fire growth models listed above, the input was passive and the feedback of the fire upon the atmospheric wind and humidity are not accounted for.
https://en.wikipedia.org/wiki?curid=20115268
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Several unrelated events conspired to greatly delay further progress. On 1 January 1942 Lovell was sent to work on the H2S radar project and was replaced by Arthur Ernest Downing. This delayed the project just long enough that it got caught up in a great debate that broke out in the summer of 1942 about the use of "window", today known as "chaff". Window caused false returns on radar displays that made it difficult to tell where the bombers were amid a sea of blips. Bomber Command had been pressing to use window over Germany to reduce their losses, which were beginning to mount as the German defensive network improved. Fighter Command was concerned that if Bomber Command used it over Germany, the Germans would return the favour and use it over the UK.
https://en.wikipedia.org/wiki?curid=44128965
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This new edition contained an extended discussion of eugenics (Chapter XXXII "The Improvement of the Human Race", pp. 394–404), but the section quoted above on "The Remedy" removed the words "If such people were lower animals, we would probably kill them off to prevent them from spreading. Humanity will not allow this...". (page 400). The supposed history of the Jukes family and the Kallikak family was advanced (pages 398–399). The section "Parasitism and its Cost to Society" was unchanged but for the insertion of the sentence "It is estimated that between 25% and 50% of all prisoners in penal institutions are feeble-minded." The new edition retained the section "The Races of Man" as written, with two changes about "caucasians": They were no longer described as "the highest type of all", and "the Hindus and Arabs of Asia" were included among the enumerated caucasians (page 251).
https://en.wikipedia.org/wiki?curid=2873458
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The main part of the Cathedral's first floor is the Commons Room, called one of the "great architectural fantasies of the twentieth century", is a fifteenth-century English perpendicular Gothic-style hall that covers half an acre (2,000 m) and extends upward four stories, reaching tall. The room was a gift of Andrew Mellon. It is a piece of true Gothic architecture; no steel supports were used in the construction of its arches. Each arch is a true arch, and they support their own weight. Each base for the arches weighs five tons, and it is said that they are so firmly placed that each could hold a large truck. The large central piers act only as screens for the structural steel that holds up the upper floors of the building.
https://en.wikipedia.org/wiki?curid=768929
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Australia also formed small-scale raiding and reconnaissance forces, most of which were grouped together as the Allied Intelligence Bureau. Z Special Unit conducted raids far behind the front line, including a successful raid on Singapore in September 1943. M Special Unit, coastwatchers and smaller AIB units also operated behind Japanese lines to collect intelligence. AIB parties were often used to support Australian Army units and were assigned to inappropriate tasks such as tactical reconnaissance and liaison. AIB missions in Timor and Dutch New Guinea were also hampered by being placed under the command of unpopular Dutch colonial administrators. The RAAF formed a specially equipped unit (No. 200 Flight) in 1945 to support these operations by transporting and supplying AIB parties in areas held by the Japanese.
https://en.wikipedia.org/wiki?curid=4578255
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Equatorial telescope mounts come in many designs. In the last twenty years motorized tracking has increasingly been supplemented with computerized object location. There are two main types. Digital setting circles take a small computer with an object database that is attached to encoders. The computer monitors the telescope's position in the sky. The operator must push the telescope. Go-to systems use (in most cases) a worm and ring gear system driven by servo or stepper motors, and the operator need not touch the instrument at all to change its position in the sky. The computers in these systems are typically either hand-held in a control "paddle" or supplied through an adjacent laptop computer which is also used to capture images from an electronic camera. The electronics of modern telescope systems often include a port for autoguiding. A special instrument tracks a star and makes adjustment in the telescope's position while photographing the sky. To do so the autoguider must be able to issue commands through the telescope's control system. These commands can compensate for very slight errors in the tracking performance, such as periodic error caused by the worm drive that makes the telescope move.
https://en.wikipedia.org/wiki?curid=1055334
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Most polar molecules have low solubility in the hydrocarbon core of a lipid bilayer and, as a consequence, have low permeability coefficients across the bilayer. This effect is particularly pronounced for charged species, which have even lower permeability coefficients than neutral polar molecules. Anions typically have a higher rate of diffusion through bilayers than cations. Compared to ions, water molecules actually have a relatively large permeability through the bilayer, as evidenced by osmotic swelling. When a cell or vesicle with a high interior salt concentration is placed in a solution with a low salt concentration it will swell and eventually burst. Such a result would not be observed unless water was able to pass through the bilayer with relative ease. The anomalously large permeability of water through bilayers is still not completely understood and continues to be the subject of active debate. Small uncharged apolar molecules diffuse through lipid bilayers many orders of magnitude faster than ions or water. This applies both to fats and organic solvents like chloroform and ether. Regardless of their polar character larger molecules diffuse more slowly across lipid bilayers than small molecules.
https://en.wikipedia.org/wiki?curid=158011
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City College began charging tuition in 1976. But after three decades, by 1999, the CUNY Board of Trustees voted to eliminate remedial classes at all CUNYs senior colleges, thereby eliminating a central pillar of the policy of Open Admissions and effectively ending it. Students who could not meet the academic entrance requirements for CUNY's senior colleges were forced to enroll in the system's community colleges, where they could prepare for an eventual transfer to one of the 4-year institutions. Since this decision, all CUNY senior colleges, especially CCNY, have begun to rise in prestige nationally, as evinced by school rankings and incoming freshman GPA and SAT scores. In addition, the end of open admissions sparked a change in CUNY's student demographics, with the number of Black and Hispanic students decreasing and the number of White Caucasian and Asian students increasing.
https://en.wikipedia.org/wiki?curid=7954388
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Anteriorly, the condyles are slightly prominent and are separated by a smooth shallow articular depression called the patellar surface. Posteriorly, they project considerably and a deep notch, the Intercondylar fossa of femur, is present between them. The lateral condyle is the more prominent and is the broader both in its antero-posterior and transverse diameters. The medial condyle is the longer and, when the femur is held with its body perpendicular, projects to a lower level. When, however, the femur is in its natural oblique position the lower surfaces of the two condyles lie practically in the same horizontal plane. The condyles are not quite parallel with one another; the long axis of the lateral is almost directly antero-posterior, but that of the medial runs backward and medialward. Their opposed surfaces are small, rough, and concave, and form the walls of the intercondyloid fossa. This fossa is limited above by a ridge, the intercondyloid line, and below by the central part of the posterior margin of the patellar surface. The posterior cruciate ligament of the knee joint is attached to the lower and front part of the medial wall of the fossa and the anterior cruciate ligament to an impression on the upper and back part of its lateral wall.
https://en.wikipedia.org/wiki?curid=188497
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The signature of baryon acoustic oscillations (BAO) can be observed in the distribution of tracers of the matter density field and used to measure the expansion history of the Universe. BAO can also be measured using purely photometric data, though at less significance. DES team observation samples consists of 7 million galaxies distributed over a footprint of 4100 degformula_16 with 0.6< formula_17 < 1.1 and a typical redshift uncertainty of 0.03(1+z). From their statistics, they combine the likelihoods derived from angular correlations and spherical harmonics to constrain the ratio of comoving angular diameter distance formula_18 at the effective redshift of our sample to the sound horizon scale at the drag epoch.
https://en.wikipedia.org/wiki?curid=9075104
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Richardson became involved in a scandal which led to his arrest in January 1846 in Pocklington. He was then charged the following month, February, for colluding with his daughter in the murder of Theodore Horatio Richardson who was their incest son. On 11 May 1846, the two were put to trial at the Old Bailey court. He was then relieved of his job at the Observatory even though incest was not considered a crime in those days in Britain. The matter might have been dismissed had he not made the mistake of burying his son secretly in their garden, where a labourer digging a cesspool for Richardson discovered the child's coffin on 22 January 1846. In addition, neither the birth nor the death of the child had been recorded with the authorities. This then became the basis of the murder charge against him. This incident drew the attention from local to national audiences, with the proceedings of the court receiving considerable coverage by the major newspapers. The charges against the two were later dropped leading to their acquittal by the court. After this incident, Richardson moved back to live in Pocklington, where he lived until his death at the age of 75.
https://en.wikipedia.org/wiki?curid=60630236
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Bloom Energy Servers stack small fuel cells to operate in concert. Bloom Energy's approach of assembling fuel-cell stacks that enables individual plates to expand and contract at the same rate at high temperatures. However, other solid oxide fuel cell producers have solved the problem of different expansion rates of cells in the past. Scott Samuelsen of the University of California, Irvine National Fuel Cell Research Center questioned the operational life of Bloom Servers. "At this point, Bloom has excellent potential, but they have yet to demonstrate that they've met the bars of reliability." Lawrence Berkeley National Laboratory expert Michael Tucker claimed, "Because they operate at high temperatures, they can accept other fuels like natural gas and methane, and that's an enormous advantage... The disadvantage is that they can shatter as they are heating or cooling."
https://en.wikipedia.org/wiki?curid=26284297
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The Space Task Group was a working group of NASA engineers created in 1958, tasked with managing America's human spaceflight programs. Headed by Robert Gilruth and based at the Langley Research Center in Hampton, Virginia, it managed Project Mercury and follow-on plans. After President John F. Kennedy set the goal in 1961 for the Apollo Program to land a man on the Moon, NASA decided a much larger organization and a new facility was required to perform the Task Group's function, and it was transformed into the Manned Spacecraft Center (now the Lyndon B. Johnson Space Center), located in Houston, Texas.
https://en.wikipedia.org/wiki?curid=7628698
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In 1951, 29, 141, 85 and 264 squadrons each received a number of NF.11 aircraft, the first of the Meteor night fighters. It was rolled out across the RAF until the final deliveries in 1954. A "tropicalised" version of the NF.11 for the Middle East was developed; first flying on 23 December 1952 as the "NF.13". The aircraft equipped No. 219 Squadron RAF at Kabrit and No. 39 Squadron at Fayid, both in Egypt. The aircraft served during the Suez crisis and remained with No. 39 Squadron after they were withdrawn to Malta until 1958. Several problems were encountered: the heavily framed T.7 canopy made landings tricky due to limited visibility, the under-wing external fuel tanks tended to break up when the wing cannons were fired, and gun harmonisation, normally set to about 400 yards, was poor due to the wings flexing in flight. Belgium (24), Denmark (20) and France (41) were foreign customers for the NF.11. Ex-RAF NF.13s were sold to France (two), Syria (six), Egypt (six) and Israel (six).
https://en.wikipedia.org/wiki?curid=42702
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Around 2010, a company called Sunvention Solar Energy created a device similar to the NASA design that they say can pump 100,000 gallons per day, purely off of solar energy and the Stirling cycle, and costing only US$1,250 This apparatus, much like the others, uses a large solar dish to collect heat from the sun to create a high temperature source, and also uses low temperature water from a nearby stream as its low temperature source. This provides a great temperature range, which in turn provides more power. The work in Sunvention’s apparatus pumps the water into nearby crop fields, providing a “low-cost, low-technology pump having particular utility in irrigation systems employed in underdeveloped arid regions of the earth.”
https://en.wikipedia.org/wiki?curid=35535735
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Allergies from food have been noted to become common disease nowadays. The food allergies in the clinical demonstration present different signs, for example mild symptoms from itching in the mouth and swelling of the lips to critical anaphylactic response result in fatal consequences. According to statistic, about 2% adults and 8% children are experiencing hypersensitivity from industrialized countries. In order to reduce potential threatening reactions for life, avoiding the consumption from these allergenic foods strictly is  the valid therapy. Therefore, sufficient description in term of potentially allergenic ingredients existing in food products is crucial and indispensable which can be monitored through protein detection.
https://en.wikipedia.org/wiki?curid=60902291
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Schleier-Smith's research career began an opportunity to do nanotechnology research at the MITRE Corporation while she was a student at Thomas Jefferson High School for Science and Technology in Alexandria, Virginia. She went on to attend Harvard University as an undergraduate, receiving a B.A. in Chemistry and Physics and (secondarily) Mathematics in 2005. Afterwards, Schleier-Smith pursued graduate studies with the supervision of Vladan Vuletić at MIT on a National Science Foundation Graduate Research Fellowship. Her Ph.D. thesis introduced a quantum-enhanced atomic clock and was recognized by the Hertz Foundation with a Doctoral Thesis Prize. During her time in Boston, Schleier-Smith also completed the Boston Marathon six times. Subsequently, Schleier-Smith conducted postdoctoral research at LMU Munich and Max Planck Institute of Quantum Optics.
https://en.wikipedia.org/wiki?curid=60139557
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Surgical treatments such as nerve grafting, tendon lengthening, tendon transfers, and limb lengthening and shortening were used extensively during this time. Patients with residual paralysis were treated with braces and taught to compensate for lost function with the help of calipers, crutches and wheelchairs. The use of devices such as rigid braces and body casts, which tended to cause muscle atrophy due to the limited movement of the user, were also touted as effective treatments. Massage and passive motion exercises were also used to treat patients with polio. Most of these treatments proved to be of little therapeutic value, however several effective supportive measures for the treatment of polio did emerge during these decades including the iron lung, an anti-polio antibody serum, and a treatment regimen developed by Sister Elizabeth Kenny.
https://en.wikipedia.org/wiki?curid=11110672
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The first class was graduated in 1826, receiving their degrees only after the disposition of a lawsuit seeking to close the school. The first classes were held in the Tivoli Theater on Prune Street in Philadelphia, which had the first medical clinic attached to a medical school. Owing to the teaching philosophy of Dr. McClellan, classes focused on clinical practice. In 1828, the Medical Department moved to the Ely Building, which allowed for a large lecture space and the "Pit," a 700-seat amphitheater to allow students to view surgeries. This building had an attached hospital, the second such medical school/hospital arrangement in the nation, servicing 441 inpatients and 4,659 outpatients in its first year of operation. The future founder of gynecology J. Marion Sims studied there from 1834 to 1835, when he graduated. The relationship with Jefferson College survived until 1838, when the Medical Department received a separate charter, allowing it to operate separately as the Jefferson Medical College. At this time, all instructors, including McClellan, were vacated from the school and the trustees hired all new individuals to teach. This has been considered the time at which the school came to be considered a "legitimate" medical school.
https://en.wikipedia.org/wiki?curid=211112
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Starting in 2011, Google Brain built DistBelief as a proprietary machine learning system based on deep learning neural networks. Its use grew rapidly across diverse Alphabet companies in both research and commercial applications. Google assigned multiple computer scientists, including Jeff Dean, to simplify and refactor the codebase of DistBelief into a faster, more robust application-grade library, which became TensorFlow. In 2009, the team, led by Geoffrey Hinton, had implemented generalized backpropagation and other improvements which allowed generation of neural networks with substantially higher accuracy, for instance a 25% reduction in errors in speech recognition.
https://en.wikipedia.org/wiki?curid=48508507
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GEC was working on producing a fully sealed version of the magnetron, as opposed to one that used an external vacuum pump. After inventing a new sealing method using gold wire and adapting the chamber of a Colt revolver as a drilling template, they produced the E1188 in early July 1940. This produced the same amount of power as the original Randall-Boot model, about 1 kW at around 10 cm. Within a few weeks they had made two improvements, moving from six to eight resonators, and replacing the cathode with an oxide-coated version. The resulting E1189 was capable of generating 10 kW of power at 9.1 cm, an order of magnitude better than any existing microwave device. The second E1189 was sent to the AMRE lab, which received it on 19 July.
https://en.wikipedia.org/wiki?curid=43764346
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Fluoride glass is a class of non-oxide optical quality glasses composed of fluorides of various metals. Because of their low viscosity, it is very difficult to completely avoid crystallization while processing it through the glass transition (or drawing the fiber from the melt). Thus, although heavy metal fluoride glasses (HMFG) exhibit very low optical attenuation, they are not only difficult to manufacture, but are quite fragile, and have poor resistance to moisture and other environmental attacks. Their best attribute is that they lack the absorption band associated with the hydroxyl (OH) group (3,200–3,600 cm; i.e., 2,777–3,125 nm or 2.78–3.13 μm), which is present in nearly all oxide-based glasses.
https://en.wikipedia.org/wiki?curid=3372377
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Gravity bombs are designed to be dropped from planes, which requires that the weapon be able to withstand vibrations and changes in air temperature and pressure during the course of a flight. Early weapons often had a removable core for safety, known as in flight insertion (IFI) cores, being inserted or assembled by the air crew during flight. They had to meet safety conditions, to prevent accidental detonation or dropping. A variety of types also had to have a fuse to initiate detonation. US nuclear weapons that met these criteria are designated by the letter "B" followed, without a hyphen, by the sequential number of the "physics package" it contains. The "B61", for example, was the primary bomb in the US arsenal for decades.
https://en.wikipedia.org/wiki?curid=3247324
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UHTCs, specifically Hf and Zr based diboride, are being developed to handle the forces and temperatures experienced by leading vehicle edges in atmospheric reentry and sustained hypersonic flight. The surfaces of hypersonic vehicles experience extreme temperatures in excess of 2,500 °C while also being exposed to high-temperature, high-flow-rate oxidizing plasma. The material design challenges associated with developing such surfaces have so far limited the design of orbital re-entry bodies and hypersonic air-breathing vehicles such as scramjets and DARPA's HTV because the bow shock in front of a blunt body protects the underlying surface from the full thermal force of the onrushing plasma with a thick layer of relatively dense and cool plasma.
https://en.wikipedia.org/wiki?curid=38050893
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Targeted contrast-enhanced ultrasound works in a similar fashion, with a few alterations. Microbubbles targeted with ligands that bind certain molecular markers that are expressed by the area of imaging interest are still injected systemically in a small bolus. Microbubbles theoretically travel through the circulatory system, eventually finding their respective targets and binding specifically. Ultrasound waves can then be directed on the area of interest. If a sufficient number of microbubbles have bound in the area, their compressible gas cores oscillate in response to the high frequency sonic energy field, as described in the ultrasound article. The targeted microbubbles also reflect a unique echo that stands in stark contrast to the surrounding tissue due to the orders of magnitude mismatch between microbubble and tissue echogenicity. The ultrasound system converts the strong echogenicity into a contrast-enhanced image of the area of interest, revealing the location of the bound microbubbles. Detection of bound microbubbles may then show that the area of interest is expressing that particular molecular marker, which can be indicative of a certain disease state, or identify particular cells in the area of interest.
https://en.wikipedia.org/wiki?curid=3287565
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On August 27, 2020, the NEXRAD radar site located in Lake Charles, Louisiana, was destroyed by Hurricane Laura as the eye of the Category 4 storm—which packed wind gusts recorded around in the city—passed over the site after it made landfall. NEXRAD radars based in Houston, Shreveport and Fort Polk were used to fill gaps in radar coverage within portions of Southwestern Louisiana until the Lake Charles site was rebuilt; the NWS Radar Operations Center also deployed a SMART-R vehicle on loan from the University of Oklahoma to provide supplemental radar data on Hurricane Delta in advance of its track into the region (nearly paralleling that of Hurricane Laura) in late October. Operational service to the Lake Charles NEXRAD radar site was restored in January 2021, following a four-month, $1.65-million reconstruction project that included the replacement of the radome and internal equipment and repairs to the station's radome pedestal, tower, fence and equipment shelters.
https://en.wikipedia.org/wiki?curid=314409
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Infection and Immunity is a peer-reviewed medical journal published by the American Society for Microbiology. It focuses on interactions between bacterial, fungal, or parasitic pathogens and their hosts. Areas covered include molecular pathogenesis, cellular microbiology, bacterial infection, host responses and inflammation, fungal and parasitic infections, microbial immunity and vaccines, and molecular genomics. The journal publishes primary research articles, editorials, commentaries, minireviews, and a spotlight report highlighting articles of particular interest selected by the editors. Articles are freely accessible after 6 months (delayed open access). Through its "Global Outreach Program," free online access is available to qualified microbiologists in eligible developing countries.
https://en.wikipedia.org/wiki?curid=9793651
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The MiG-29's good operational record prompted India to sign a deal with Russia in 2005 and 2006 to upgrade all of its MiG-29s for US$888 million. Under the deal, the Indian MiGs were modified to be capable of deploying the R-77/RVV-AE (AA-12 'Adder') air-to-air missile. The missiles had been successfully tested in October 1998 and were integrated into the IAF's MiG-29s. The IAF has also awarded the MiG Corporation another US$900 million contract to upgrade all of its 69 operational MiG-29s. These upgrades will include a new avionics kit, with the N019 radar being replaced by a Phazotron "Zhuk-M" radar. The aircraft is also being equipped to enhance beyond-visual-range combat ability and for air-to-air refuelling to increase endurance. In 2007, Russia also gave India's Hindustan Aeronautics Limited (HAL) a licence to manufacture 120 RD-33 series 3 turbofan engines for the upgrade. The upgrade will also include a new weapon control system, improved cockpit ergonomics, air-to-air missiles, high-accuracy air-to-ground missiles and guided bombs. The first six MiG-29s will be upgraded in Russia while the remaining 63 MiGs will be upgraded at the HAL facility in India. India also awarded a multi-million-dollar contract to Israel Aircraft Industries to provide avionics and subsystems for the upgrade.
https://en.wikipedia.org/wiki?curid=185653
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The UNT Center for Human Identification (UNTCHI) was created in 2004 and consists of the Laboratory for Molecular Identification, the Laboratory of Forensic Anthropology, and the Forensic Services Unit. Founded in 1986, the Laboratory of Forensic Anthropology provides anthropological analysis of human remains for law enforcement and medicolegal agencies as well as other publicly supported entities, such as public defenders and district attorneys. UNTCHI analyzes DNA samples from both unidentified remains as well as reference samples submitted by family members of missing persons to law enforcement agencies nationwide. It also conducts all DNA analysis for the National Center for Missing and Exploited Children. The center is one of less than a dozen laboratories in the United States capable of mitochondrial DNA evaluation and is the largest single contributor to the Combined DNA Index System (CODIS), a database for unidentified missing person cases. The Center is the only academic center in the U.S. with access to the FBI’s next-generation CODIS 6.0 DNA Software. In 2011, UNTCHI began managing and developing the National Missing and Unidentified Persons System (NamUs) for the U.S. Department of Justice.
https://en.wikipedia.org/wiki?curid=31533662
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The NBFAC played a role in more than 45 federal law enforcement investigations of biological crimes in 2013 alone. Also in 2013, it activated unique bioforensic laboratories at biosafety level 3 with accreditation for casework operations. Its processes maintain operational capability to study more than 60 high-priority human, animal, and plant pathogens and toxins. Its sequencing methods are imperative to enable new kinds of studies. It played a central role in developing capabilities to investigate genetically modified and de novo synthetic agents (new complex molecules formed from simple molecules).
https://en.wikipedia.org/wiki?curid=8888314
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Historically, board designers used to increase the length and volume of the boards in order to allow for sailing in lighter winds, but during the late 90s, some brands like AHD, Berky, Drops, ML, Pro-Tech, Roberts and Starboard started to work on alternative solutions. They came up with designs that widened and shortened the board length whilst retaining high volume, and used larger fins to get into planing earlier. They also moved the fins further back, which prompted newer concepts with different solutions around the tail of the board to free the nose and decrease drag. To avoid ventilation in the fin area, flaps or steeped bottoms were used, the latter becoming the more widely adopted due to its durability and ease of use.
https://en.wikipedia.org/wiki?curid=3307695
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Around this time, players such as Ian Botham, Allan Lamb and David Gower all came to the end of their international careers and specifically in the case of Botham, England had trouble replacing these players. Batsmen like Graeme Hick, Mark Ramprakash, Chris Lewis and Phil Tufnell all promised and sometimes delivered a great deal, yet the side often performed badly and disappointed its fans. Following their victory in New Zealand before the Cricket World Cup, they did not win again for another two and a half years, when the side again defeated the same opponents. During this period defeats by Pakistan, India, Sri Lanka and Australia culminated in Gooch stepping down in the summer of 1993 as captain, to be replaced by his partner at the top of the order, Michael Atherton.
https://en.wikipedia.org/wiki?curid=10829204
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OFDM enables reliable broadband communications by distributing user data across a number of closely spaced, narrowband subchannels. This arrangement makes it possible to eliminate the biggest obstacle to reliable broadband communications, intersymbol interference (ISI). ISI occurs when the overlap between consecutive symbols is large compared to the symbols’ duration. Normally, high data rates require shorter duration symbols, increasing the risk of ISI. By dividing a high-rate data stream into numerous low-rate data streams, OFDM enables longer duration symbols. A cyclic prefix (CP) may be inserted to create a (time) guard interval that prevents ISI entirely. If the guard interval is longer than the delay spread—the difference in delays experienced by symbols transmitted over the channel—then there will be no overlap between adjacent symbols and consequently no intersymbol interference. Though the CP slightly reduces spectral capacity by consuming a small percentage of the available bandwidth, the elimination of ISI makes it an exceedingly worthwhile tradeoff.
https://en.wikipedia.org/wiki?curid=41824003
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Most agile development methods break product development work into small increments that minimize the amount of up-front planning and design. Iterations, or sprints, are short time frames (timeboxes) that typically last from one to four weeks. Each iteration involves a cross-functional team working in all functions: planning, analysis, design, coding, unit testing, and acceptance testing. At the end of the iteration a working product is demonstrated to stakeholders. This minimizes overall risk and allows the product to adapt to changes quickly. An iteration might not add enough functionality to warrant a market release, but the goal is to have an available release (with minimal bugs) at the end of each iteration. Through incremental development, products have room to "fail often and early" throughout each iterative phase instead of drastically on a final release date. Multiple iterations might be required to release a product or new features. Working software is the primary measure of progress.
https://en.wikipedia.org/wiki?curid=639009
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The facility will be based on four sites. Three of them are presently being implemented in the Czech Republic, Hungary and Romania, with an investment volume exceeding €850 million, mostly stemming from the European Regional Development Fund (ERDF). In Dolní Břežany, near Prague, Czech Republic, the ELI Beamlines facility is developing short-pulse secondary sources of radiation and particles. The ELI Attosecond Light Pulse Source (ELI-ALPS) in Szeged, Hungary is establishing a unique facility which provides light sources within an extremely broad frequency range in the form of ultrashort pulses with high repetition rate. In Măgurele, Romania, the ELI Nuclear Physics (ELI-NP) facility is focusing on laser-based nuclear physics. The location of ELI's fourth pillar, the highest-intensity pillar, is still to be decided. Its laser power is expected to exceed that of the current ELI pillars by about one order of magnitude.
https://en.wikipedia.org/wiki?curid=23639320
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The gut contents consist of fragments of fibrous or vascular plant tissue, fruiting bodies, spherical seeds, and vesicular tissue (possibly from fern sporangia). The most common remains are the fibrous or vascular fragments, which are typically rather uniform in size at long and have clean cuts at their ends, perpendicular to a given fragment's long axis. Because of the small size of the fragments, they have been interpreted as having been nibbled from plants or chopped in the mouth, evidence of some method of retaining food in the mouth. These small fragments may have come from twigs or stems, but their size is more suggestive of vascular bundles in leaves. The clean cuts and lack of gastroliths suggest that the animal relied on oral processing instead of gastroliths or grit to grind food. The seeds (0.3 mm [0.01 in] across) and fruiting bodies (4.5 mm [0.18 in] across) were apparently swallowed whole. Comparisons with gut contents and scat from other modern herbivores like lizards, emus, and geese indicate that this "Kunbarrasaurus" individual had a more sophisticated process for cutting up plant material.
https://en.wikipedia.org/wiki?curid=48767246
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The new wedge-shaped Lotus 72 had very innovative car design, featuring torsion bar suspension, hip-mounted radiators, inboard front brakes and an overhanging rear wing. The 72 originally had suspension problems, but when dive and squat were designed out of the suspension the car quickly showed its superiority. Lotus's new leader, the Austrian Jochen Rindt, dominated the championship until he was killed at Monza when he crashed into some poorly installed crash barriers right before the Parabolica corner. He took the 1970 title posthumously for Lotus. Jacky Ickx won the Austrian, Canadian and Mexican Grands Prix to come second in the Drivers' Championship, having re-joined Ferrari from Brabham. Had he won the United States Grand Prix instead of Brazilian newcomer Emerson Fittipaldi, Ickx would have been crowned champion.
https://en.wikipedia.org/wiki?curid=1140091
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A theory that has gained a lot of traction recently is the "study-phase retrieval theory". This theory assumes that the first presentation is retrieved at the time of the second. This leads to an elaboration of the first memory trace. Massed presentations do not yield advantages because the first trace is active at the time of the second, so it is not retrieved or elaborated upon. Greene (1989) proposed a two-factor account of the spacing effect, combining deficient processing and study-phase retrieval accounts. Spacing effects in free recall are accounted for by the study-phase retrieval account. Under the assumption that free recall is sensitive to contextual associations, spaced items are at an advantage over massed items by the additional encoding of contextual information. Thus, the second occurrence of an item in a list reminds the observer of the previous occurrence of that same item and of its previous contextual features. Different contextual information is encoded with each presentation, whereas for massed items, the difference in context is relatively small. More retrieval cues, then, are encoded with spaced learning, which in turn leads to improved recall.
https://en.wikipedia.org/wiki?curid=903495
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Since early on, Bigelow has been intent on "pursuing markets for a variety of users including biotech and pharmaceutical companies and university research, entertainment applications and government military and civil users". The business model includes "'leasing out' small space stations or habitats made of one or more [B330] inflatable modules to different research communities or corporations". Despite these broad plans for space commercialization, the "space tourism destination" and "space hotel" monikers were frequently used by many media outlets following the 2006/2007 launches of Genesis I and Genesis II. Robert Bigelow has been explicit that he is aiming to do business in space in a new way, with "low cost and rapid turnaround, contrary to traditional NASA ISS and Space Shuttle operations and bureaucracy".
https://en.wikipedia.org/wiki?curid=754129
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In 2012, Carney and colleagues performed the first colour study on an "Archaeopteryx" specimen with the fossil of this single feather. Using scanning electron microscopy technology and energy-dispersive X-ray analysis, the team was able to detect the structure of melanosomes in the fossil. The resultant structure was then compared to that of 87 modern bird species and was determined with a high percentage of likelihood to be black in colour. While the study does not mean that "Archaeopteryx" was entirely black, it does suggest that it had some black colouration which included the coverts (or possibly the secondary remiges). Carney pointed out that this is consistent with what we know of modern flight characteristics, in that black melanosomes have structural properties that strengthen feathers for flight. In 2020, they re-performed the analysis using the specimen's melanosome imprints and an expanded dataset of birds, and predicted a matte black (non-iridescent) colouration with high probability. They reconstructed the entire feather as black, with a darker tip.
https://en.wikipedia.org/wiki?curid=34483273
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In August 1950, Sister Mary Nona McGreal was appointed president of the college and prioress of the Sisters. A new academic criterion was adopted in 1950-1951: seniors were administered the Graduate Record Examination and sophomores a series of tests from the American Council on Education. Several campus organizations, including Kappa Gamma Pi, the national Catholic Honor and Activity Society, were also established in 1951. Meanwhile, more students with different backgrounds and cultures enrolled in the college: black students, Vietnamese, Hondurans, Germans, and Colombians. Additionally, the college began in 1951 to assist in students’ preparation as teachers of Saturday classes to involve them in catechetical instruction in the parishes of the Diocese. Edgewood's chorus also formed a broadcast choir to present live programs for the Madison Catholic Hour.
https://en.wikipedia.org/wiki?curid=1756590
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Cryogenic electron microscopy (cryo-EM) is a cryomicroscopy technique applied on samples cooled to cryogenic temperatures. For biological specimens, the structure is preserved by embedding in an environment of vitreous ice. An aqueous sample solution is applied to a grid-mesh and plunge-frozen in liquid ethane or a mixture of liquid ethane and propane. While development of the technique began in the 1970s, recent advances in detector technology and software algorithms have allowed for the determination of biomolecular structures at near-atomic resolution. This has attracted wide attention to the approach as an alternative to X-ray crystallography or NMR spectroscopy for macromolecular structure determination without the need for crystallization.
https://en.wikipedia.org/wiki?curid=56452747
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Starting with the release of "Heart of the Swarm" in early 2013, the WCS transitioned into a league format as Blizzard strengthened its hold on professional "StarCraft II" competition with the introduction of WCS points that decided who would qualify for the year's biggest tournament, the WCS Global Finals. This led to fewer non-WCS events yearly as 2014 marked Major League Gaming's last "StarCraft II" event, the second large blow to the North American scene following the last NASL event in late 2012. Non-Korean competition quickly became focused almost exclusively on WCS events, unlike the largely decentralized competitive circuits of the years prior.
https://en.wikipedia.org/wiki?curid=58381235
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Syzygy tablebases were developed by Ronald de Man, released in April 2013, in a form optimized for use by a chess program during search. This variety consists of two tables per endgame: a smaller WDL (win/draw/loss) table which contains knowledge of the 50-move rule, and a larger DTZ table (distance to zero ply, i.e., pawn move or capture). The WDL tables were designed to be small enough to fit on a solid-state drive for quick access during search, whereas the DTZ form is for use at the root position to choose the game-theoretically quickest distance to resetting the 50-move rule while retaining a winning position, instead of performing a search. Syzygy tablebases are available for all 6-piece endings, and are now supported by many top engines, including Komodo, Deep Fritz, Houdini, and Stockfish. Since August 2018, all 7-piece Syzygy tables are also available.
https://en.wikipedia.org/wiki?curid=2658308
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