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The first stage in the operations that transfer information from a visual target in front of an observer into its neural representation in the brain and then allow a percept to emerge, is the imaging by the eye and the processing by the neural circuits in the retina. Some components of geometrical-optical illusions can be ascribed to aberrations at that level. Even if this does not fully account for an illusion, the step is helpful because it puts elaborate mental theories in a more secure place. The moon illusion is a good example. Before invoking concepts of apparent distance and size constancy, it helps to be sure that the retinal image hasn't changed much when the moon looks larger as it descends to the horizon.
https://en.wikipedia.org/wiki?curid=31982810
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Thomas G. Kurtz (born 14 July 1941 in Kansas City, Missouri, United States) is an American emeritus professor of Mathematics and Statistics at University of Wisconsin-Madison known for his research contributions to many areas of probability theory and stochastic processes. In particular, Kurtz’s research focuses on convergence, approximation and representation of several important classes of Markov processes. His findings appear in scientific disciplines such as systems biology, population genetics, telecommunications networks and mathematical finance.
https://en.wikipedia.org/wiki?curid=51178615
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The greatest influence on the development of the Cecchetti method was Carlo Blasis, a ballet master of the early 19th century. A student and exponent of the traditional French school of ballet, Blasis is credited as one of the most prominent ballet theoreticians and the first to publish a codified technique, the 'Traité élémentaire, théorique, et pratique de l'art de la danse' ("Elementary, Theoretical, and Practical Treatise on the Art of the Dance"). Reputedly a very rigorous teacher, Blasis insisted on his students conforming to strict technical principles when learning to dance, a philosophy which Cecchetti learnt from his own teachers, who were all students of Blasis (Giovanni Lepri, Cesare Carnesecchi Coppini and Filippo Taglioni). Consequently, the key characteristic of the Cecchetti method is the adherence to a rigid training regime, designed to develop a virtuoso technique, with the dancer having a complete understanding of the theory behind the movement.
https://en.wikipedia.org/wiki?curid=376553
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The men's rings competition was one of eight events for male competitors of the artistic gymnastics discipline contested in the gymnastics at the 2004 Summer Olympics in Athens. The qualification and final rounds took place on August 14 and August 22 at the O.A.C.A. Olympic Indoor Hall. There were 77 competitors from 28 nations, with nations competing in the team event having up to 5 gymnasts and other nations having up to 2 gymnasts. The event was won by Dimosthenis Tampakos of Greece, the nation's first victory in the rings since 1896 and second overall. Yordan Yovchev of Bulgaria took silver, while Jury Chechi of Italy earned bronze. All three men had previously won a medal in the event; they were the 9th, 10th, and 11th men to win multiple rings medals.
https://en.wikipedia.org/wiki?curid=11505842
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Starting with the Song dynasty, the imperial examination system became a more formal system and developed into a roughly three-tiered ladder from local to provincial to court exams. During the Ming dynasty (1368–1644), authorities narrowed the content down to mostly texts on Neo-Confucian orthodoxy; the highest degree, the "jinshi" (), became essential for the highest offices. On the other hand, holders of the basic degree, the "shengyuan" (), became vastly oversupplied, resulting in holders who could not hope for office. Wealthy families, especially from the merchant class, could opt into the system by educating their sons or by purchasing degrees. During the late 19th century, some critics within Qing China blamed the examination system for stifling science and technical knowledge, and urged for some reforms. At the time, China had about one civil licentiate per 1000 people. Due to the stringent requirements, out of the two or three million annual applicants who took the exams, there was only a 1% passing rate.
https://en.wikipedia.org/wiki?curid=244479
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Besides having compositional effects on the upper mantle by replenishing the large-ion lithophile elements, volcanism affects plate movement. The plates will be moved towards a geoidal low perhaps where the slab avalanche occurred and pushed away from the geoidal high that can be caused by the plumes or superplumes. This causes the continents to push together to form supercontinents and was evidently the process that operated to cause the early continental crust to aggregate into Protopangea. Dispersal of supercontinents is caused by the accumulation of heat underneath the crust due to the rising of very large convection cells or plumes, and a massive heat release resulted in the final break-up of Paleopangea. Accretion occurs over geoidal lows that can be caused by avalanche slabs or the downgoing limbs of convection cells. Evidence of the accretion and dispersion of supercontinents is seen in the geological rock record.
https://en.wikipedia.org/wiki?curid=28742
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In 1988, the studio collaborated with Steven Spielberg and Robert Zemeckis, producing "Who Framed Roger Rabbit", a comedic detective caper that mixed live-action and animation while paying homage to the Golden Age of Cartoons. Disney characters appeared with characters from Warner Bros., Metro-Goldwyn-Mayer, Universal Pictures and other rival studios for the first time in animation history. The film was a huge box-office success, winning four Academy Awards, reviving interest in animation made for theaters, and popularizing the in-depth study of the history and techniques of animation. Several aging legends in the business, such as Chuck Jones and Friz Freleng, suddenly found themselves the center of attention, receiving acclaim and accolades after decades of being virtually ignored by audiences and industry professionals alike. Additionally, the release of many older Disney features and short cartoons on home video, and the 1983 launch of the Disney Channel, renewed interest in the studio.
https://en.wikipedia.org/wiki?curid=141959
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The growing ability of neuroscientists to manipulate neurons using methods from molecular biology in combination with optical tools (e.g., Adamantidis et al. 2007) depends on the simultaneous development of appropriate behavioral assays and model organisms amenable to large-scale genomic analysis and manipulation. It is the combination of such fine-grained neuronal analysis in animals with ever more sensitive psychophysical and brain imaging techniques in humans, complemented by the development of a robust theoretical predictive framework, that will hopefully lead to a rational understanding of consciousness, one of the central mysteries of life.
https://en.wikipedia.org/wiki?curid=18345264
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In 1923, upon some 25 years of researches, dentist Weston Andrew Price of Cleveland, Ohio, published a landmark book, then a related article in the "Journal of the American Medical Association" in 1925. Price concluded that after root canal therapy, teeth routinely host bacteria producing potent toxins. Transplanting the teeth into healthy rabbits, Price and his researchers duplicated heart and arthritic diseases. Although Price noted often seeing patients "suffering more from the inconvenience and difficulties of mastication and nourishment than they did from the lesions from which their physician or dentist had sought to give them relief", his 1925 debate with John P Buckley was decided in favor of Price's position: "practically all infected pulpless teeth should be extracted". As chairman of the American Dental Association's research division, Price was a leading influence on the dentistry profession's opinion. Into the late 1930s, textbook authors relied on Price's 1923 treatise.
https://en.wikipedia.org/wiki?curid=9510615
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Traditionally markerless optical motion tracking is used to keep track on various objects, including airplanes, launch vehicles, missiles and satellites. Many of such optical motion tracking applications occur outdoors, requiring differing lens and camera configurations. High resolution images of the target being tracked can thereby provide more information than just motion data. The image obtained from NASA's long-range tracking system on space shuttle Challenger's fatal launch provided crucial evidence about the cause of the accident. Optical tracking systems are also used to identify known spacecraft and space debris despite the fact that it has a disadvantage compared to radar in that the objects must be reflecting or emitting sufficient light.
https://en.wikipedia.org/wiki?curid=396968
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Euparkeriidae is an extinct family of small carnivorous archosauriforms which lived from the Early Triassic to the Middle Triassic (Anisian). While most other early archosauriforms walked on four limbs, euparkeriids were probably facultative bipeds that had the ability to walk on their hind limbs at times. The most well known member of Euparkeriidae is the species "Euparkeria capensis", which was named by paleontologist Robert Broom from the Karoo Basin of South Africa in 1913 and is known from several nearly complete skeletons. The family name was first proposed by German paleontologist Friedrich von Huene in 1920; Huene classified euparkeriids as members of Pseudosuchia, a traditional name for crocodilian-line archosaurs from the Triassic (Pseudosuchia means "false crocodiles"). However, phylogenetic analyses performed in the 21st century place Euparkeriidae as a group of Archosauriformes, a position outside Pseudosuchia and close to the ancestry of both crocodile-line archosaurs and bird-line archosaurs (which include dinosaurs and pterosaurs). However, they are probably not direct ancestors of archosaurs.
https://en.wikipedia.org/wiki?curid=18183771
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where "R" is the loop resistance per metre and "Z" is the characteristic impedance. Making the diameter of the inner conductor larger will decrease "R" and decreasing "R" decreases the loss. On the other hand, "Z" depends on the ratio of the diameters of outer and inner conductors ("D") and will decrease with increasing inner conductor diameter thus increasing the loss. There is a specific value of "D" for which the loss is a minimum and this turns out to be 3.6. For an air dielectric coax this corresponds to a characteristic impedance of 77 Ω. The coax produced during the war was rigid air-insulated pipe, and this remained the case for some time afterwards. The second requirement is for maximum power handling and was an important requirement for radar. This is not the same condition as minimum loss because power handling is usually limited by the breakdown voltage of the dielectric. However, there is a similar compromise in terms of the ratio of conductor diameters. Making the inner conductor too large results in a thin insulator which breaks down at a lower voltage. On the other hand, making the inner conductor too small results in higher electric field strength near the inner conductor (because the same field energy is accumulated around smaller conductor surface) and again reduces the breakdown voltage. The ideal ratio, "D", for maximum power handling turns out to be 1.65 and corresponds to a characteristic impedance of 30 Ω in air. The 50 Ω impedance is the geometric mean of these two figures;
https://en.wikipedia.org/wiki?curid=24559346
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Singapore is an important operator of the F-5E/F variant, first ordering the aircraft in 1976 during a massive expansion of the city-state's armed forces; delivery of this first batch of 18 F-5Es and three F-5Fs was completed by late February 1979, equipping the newly formed-up No. 144 "Black Kite" Squadron at Tengah Air Base. At the end of 1979, an order was placed for six more F-5Es, which were delivered by 1981. In 1982, an order for three more F-5Fs was placed, these were forward delivered in September 1983 to RAF Leuchars in Scotland where they were taken over by pilots of the Republic of Singapore Air Force (RSAF). In 1983, the type took over the duties of airborne interception from the Royal Australian Air Force's Mirage IIIOs detachment (rotated between No. 3 & No. 75 Squadron RAAF) stationed at "Tengah".
https://en.wikipedia.org/wiki?curid=11142
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Maglev (derived from magnetic levitation) is a system of transportation that uses magnetic levitation to suspend, guide and propel vehicles with magnets rather than using mechanical methods, such as wheels, axles and bearings. With maglev a vehicle is levitated a short distance away from a guide way using magnets to create both lift and thrust. Maglev vehicles are claimed to move more smoothly and quietly and to require less maintenance than wheeled mass transit systems. It is claimed that non-reliance on friction also means that acceleration and deceleration can far surpass that of existing forms of transport. The power needed for levitation is not a particularly large percentage of the overall energy consumption; most of the power used is needed to overcome air resistance (drag), as with any other high-speed form of transport.
https://en.wikipedia.org/wiki?curid=49023
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This may be due to medications, dehydration, significant bleeding or infection. The most susceptible individuals are elderly frail individuals, or persons who are dehydrated from hot environments or inadequate fluid intake. For example, medical students would be at risk for orthostatic hypotensive syncope while observing long surgeries in the operating room. There is also evidence that exercise training can help reduce orthostatic intolerance. More serious orthostatic hypotension is often the result of certain commonly prescribed medications such as diuretics, β-adrenergic blockers, other anti-hypertensives (including vasodilators), and nitroglycerin. In a small percentage of cases, the cause of orthostatic hypotensive faints is structural damage to the autonomic nervous system due to systemic diseases (e.g., amyloidosis or diabetes) or in neurological diseases (e.g., Parkinson's disease).
https://en.wikipedia.org/wiki?curid=20254750
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In an attempt to secure the institution, Prof Egwunyenga constructed a fence from one end of the institution to the other with the school gate properly tucked at the middle. An upgrade and re-equipping of certain departments like department of hotel and tourism management, department of welding and fabrication, and the school library to NBTE standards was carried out. Besides, the polytechnic under the management of Prof Egwunyenga commenced the construction of Lecture Hall complex a building made up of four large classrooms and about 18 offices. The Polytechnic was also a beneficiary of AGIP and TETFUND infrastructural projects, like the ICT building, the AGIP halls among others. Part of the institution was also landscaped. In furtherance of the Polytechnic goal of educating its graduate in job creation, Prof. Egwunyenga successfully initiated the establishment of Student’s Resource and Entrepreneurial Development Centre. Mr Oseafiana as deputy rector began to function as the Acting Rector. As acting Rector, Mr Steve Oseafiana consolidated the gains under Professor Egwunyenga.
https://en.wikipedia.org/wiki?curid=52431379
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In blood, anemia, hypoalbuminemia, and eosinophilia may be observed in all types of fasciolosis. Elevation of liver enzyme activities, such a glutamate dehydrogenase (GLDH), gamma-glutamyl transferase (GGT), and lactate dehydrogenase (LDH), is detected in subacute or chronic fasciolosis from 12 to 15 weeks after ingestion of metacercariae. Economical effect of fasciolosis in sheep consists in sudden deaths of animals as well as in reduction of weight gain and wool production. In goats and cattle, the clinical manifestation is similar to sheep. However, acquired resistance to "F. hepatica" infection is well known in adult cattle. Calves are susceptible to disease but in excess of 1000 metacercariae are usually required to cause clinical fasciolosis. In this case the disease is similar to sheep and is characterized by weight loss, anemia, hypoalbuminemia and (after infection with 10,000 metacercariae) death. Importance of cattle fasciolosis consist in economic losses caused by condemnation of livers at slaughter and production losses especially due to reduced weight gain.
https://en.wikipedia.org/wiki?curid=1043902
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After 347 sorties with no enemy contact, the 1st and 14th Fighter Groups transferred from the UK to the 12th Air Force in North Africa as part of the force being built up for Operation Torch. The Lightning's long range allowed the pilots to fly their fighters over the Bay of Biscay, skirting neutral Spain and Portugal to refuel in Morocco. The P-38s were initially based at Tafaroui Airfield in Algeria alongside P-40 Warhawks and the rest of the 12th Air Force. P-38s were first involved in North African combat operations on 11 November 1942. The first North African P-38 kill was on 22 November, when Lieutenant Mark Shipman of the 14th downed an Italian airplane with twin engines. Shipman later made two more kills – a Messerschmitt Bf 109 fighter and a very large Me 323 Gigant transport.
https://en.wikipedia.org/wiki?curid=25041
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The Fo.147 was to have been capable of speeds in excess of Mach 2, with the speed limit set by the temperature of the structure as a result of kinetic heating. It had a maximum all-up weight of , comparing well with the Gnat 5's more restrictive maximum. According to aviation author Derek Wood, the Fo.147: "would have provided a first-class flying test-bed for variable geometry theories...even a VG conversion of the standard Gnat Mk 2 fighter would have been an invaluable research tool". However, neither the Fo.147 nor its successor, the Fo.148, would be developed to the prototype stage; the RAF showed little interest in the need for a variable-geometry trainer, although it intended to procure the General Dynamics F-111K strike aircraft.
https://en.wikipedia.org/wiki?curid=495874
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One of the projects took Pei back to Dallas, Texas, to design the Morton H. Meyerson Symphony Center. The success of city's performing artists, particularly the Dallas Symphony Orchestra then led by conductor Eduardo Mata, led to interest by city leaders in creating a modern center for musical arts that could rival the best halls in Europe. The organizing committee contacted 45 architects, but at first Pei did not respond, thinking that his work on the Dallas City Hall had left a negative impression. One of his colleagues from that project, however, insisted that he meet with the committee. He did and, although it would be his first concert hall, the committee voted unanimously to offer him the commission. As one member put it: "We were convinced that we would get the world's greatest architect putting his best foot forward."
https://en.wikipedia.org/wiki?curid=15155
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Critics argued that the $325 million contract NASA had with Russia was the only thing keeping the Russian space program alive, and only the Space Shuttle was keeping "Mir" aloft. NASA also had to pay hefty fees for training manuals and equipment used by astronauts training at Star City. Problems came to a head when ABC's "Nightline" revealed that there was a distinct possibility of embezzlement of American finances by the Russian authorities in order to build a suite of new cosmonaut houses in Moscow, or else that the building projects were being funded by the Russian Mafia. NASA administrator Goldin was invited onto "Nightline" to defend the homes but he refused to comment. NASA's office for external affairs was quoted as saying that "What Russia does with its own money is their business."
https://en.wikipedia.org/wiki?curid=976586
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As of October 2020, among its notable alumni, faculty and researchers are 11 Nobel Laureates, 5 Fields Medalists, 12 Gottfried Wilhelm Leibniz Prize winners as well as some of the most gifted minds in Natural science, e.g. August Kekulé, Heinrich Hertz and Justus von Liebig; Eminent mathematicians, such as Karl Weierstrass, Felix Klein, Friedrich Hirzebruch and Felix Hausdorff; Major philosophers, such as Friedrich Nietzsche, Karl Marx, and Jürgen Habermas; Famous German poets and writers, for example Heinrich Heine, Paul Heyse and Thomas Mann; Painters, like Max Ernst; Political theorists, for instance Carl Schmitt and Otto Kirchheimer; Statesmen, viz. Konrad Adenauer and Robert Schuman; famous economists, like Walter Eucken, Ferdinand Tönnies and Joseph Schumpeter; and furthermore Prince Albert, Pope Benedict XVI and Wilhelm II.
https://en.wikipedia.org/wiki?curid=89061
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The Military Nutrition Division, in collaboration with the Pennington Biomedical Research Center, has made several scientific advances in understanding the energy and nutritional requirements of healthy individuals performing in extreme environments, addressed comprehensive menu modification and enabled the development of improved food composition databases, and developed weight control intervention programs for soldiers. This alliance has also allowed for investigation of performance-enhancing ration components (PERCs), improving human performance by at least 15%, and leading to developments such as the HOOAH! energy bar and the ERGO (Energy Rich Glucose Optimized) energy drink.
https://en.wikipedia.org/wiki?curid=26529555
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It is important that the gas mixture in a cylinder is thoroughly mixed before analysing or the results will be inaccurate. When partial pressure or mass blending is done at low flow rates the gases entering the cylinder are not moving fast enough to ensure good mixing, and particularly when blends contain Helium, they may tend to remain in layers due to density differences. This is termed stratification, and if left long enough, diffusion will ensure complete mixing. However, if the gas is to be analysed soon after blending, mechanical agitation is recommended. This may be by lying a single cylinder on a flat surface and rolling it for a short period, but twins are more usually inverted a few times. Stratification is more pronounced with blends containing helium, but can also lead to inaccurate analysis of Nitrox blends.
https://en.wikipedia.org/wiki?curid=996061
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It is important that the gas mixture in a cylinder is thoroughly mixed before analysing or the results will be inaccurate. When partial pressure or mass blending is done at low flow rates the gases entering the cylinder are not moving fast enough to ensure good mixing, and particularly when blends contain helium, they may tend to remain in layers due to density differences. This is termed stratification, and if left long enough, diffusion will ensure complete mixing. However, if the gas is to be analysed soon after blending, mechanical agitation is recommended. This may be by lying a single cylinder on a flat surface and rolling it for a short period, but twins are more usually inverted a few times. Stratification is more pronounced with blends containing helium, but can also lead to inaccurate analysis of nitrox blends.
https://en.wikipedia.org/wiki?curid=39089192
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The two types of inheritance during Han included the common inheritance of property from the deceased, which all social groups (except for slaves) participated in, and the inheritance of titles, which only the people of twenty ranks, nobility, and royalty could enjoy. In the first form, officials and commoners bequeathed an equal share of property to each of their sons in their will. This excluded daughters, who married into other families and thus did not carry on the family name. However, daughters did receive a portion of the family property in the form of their marriage dowries, which were sometimes equal to a brother's share of wealth in the will. The second type of inheritance involved the practice of primogeniture, where the official title was inherited by only one son. This was as true of the emperor as it was for any king, marquess, or commoner of the twenty ranks. However, to limit the power of the kings while still upholding primogeniture, an imperial edict of 127 BCE stated that kings had to divide the territories of their kingdoms between the chosen successor (i.e. heir apparent) and the kings' brothers, who were made marquesses, thus establishing new marquessates and effectively reducing the size of every kingdom with each generation.
https://en.wikipedia.org/wiki?curid=21786810
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Conductive framework materials have similar mechanisms for sensing; however these materials may be designed with installed active sites tuned for a specific molecular interaction. Bimetallic metallophthalocyanine metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) have shown promise in single device chemiresistors at sensing hydrogen sulfide, ammonia, and nitric oxide. The development of these materials as chemiresistors allows for strategic design of arrays capable of targeted molecular interactions, which can be employed to develop array components tailored to sensing specific compounds. Computational research of several MOFs has also focused on optimizing which combinations of MOFs are best suited for sensing particular components in various mixtures. The focus on curation of framework array components demonstrated the opportunity to design robust sensor arrays experimentally and computationally.
https://en.wikipedia.org/wiki?curid=66888952
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Prior to the flooding, units 1, 2 and 4 were at full power, while unit 3 was shut down for refuelling. Starting from 7:30 pm all four units lost their 225 kV power supplies, while units 2 and 4 also lost their 400 kV power supplies. The isolator circuits that should have allowed units 2 and 4 to supply themselves with electricity also failed, causing these two reactors to automatically shut down, and diesel backup generators started up, maintaining power to plants 2 and 4 until the 400 kV supply was restored at around 10:20 pm. In the pumping room for unit 1, one set of the two pairs of pumps in the Essential Service Water System failed due to flooding; had both sets failed then the safety of plant would have been endangered. In both units 1 and 2, flooding in the fuel rooms put the low-head safety injection pumps and the containment spray pumps, part of the Emergency Core Cooling System (a back-up system in case of coolant loss) out of use. Over the following days, an estimated of water would be pumped out of the flooded buildings.
https://en.wikipedia.org/wiki?curid=31256193
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By understanding the components and mechanisms of intracellular transport it is possible to see its implication in diseases. Defects encompass improper sorting of cargo into transport carriers, vesicle budding, issues in movement of vesicles along cytoskeletal tracks, and fusion at the target membrane. Since the life cycle of the cell is a highly regulated and important process, if any component goes awry there is the possibility for deleterious effects. If the cell is unable to correctly execute components of the intracellular pathway there is the impending possibility for protein aggregates to form. Growing evidence supports the concept that deficits in axonal transport contributes to pathogenesis in multiple neurodegenerative diseases. It is proposed that protein aggregations due to faulty transport is a leading cause of the development of ALS, Alzheimer’s and dementia.
https://en.wikipedia.org/wiki?curid=46319796
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In a Podcast interview with Social Science Space Massey talks about the idea of physical space being alive: "A lot of what I've been trying to do over the all too many years when I’ve been writing about space is to bring space alive, to dynamize it and to make it relevant, to emphasize how important space is in the lives in which we live. Most obviously I would say that space is not a flat surface across which we walk; Raymond Williams talked about this: you’re taking a train across the landscape – you’re not traveling across a dead flat surface that is space: you’re cutting across myriad stories going on. So instead of space being this flat surface it's like a pincushion of a million stories: if you stop at any point in that walk there will be a house with a story. Raymond Williams spoke about looking out of a train window and there was this woman clearing the grate, and he speeds on and forever in his mind she’s stuck in that moment. But actually, of course, that woman is in the middle of doing something, it’s a story. Maybe she's going away tomorrow to see her sister, but really before she goes she really must clean that grate out because she’s been meaning to do it for ages. So I want to see space as a cut through the myriad stories in which we are all living at any one moment. Space and time become intimately connected."
https://en.wikipedia.org/wiki?curid=7505043
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As a further measure, in order to utilize the heat content of the exhaust gas (temperature > 700 °C), a downstream heat/power coupling is technically possible or has already been tested on a large scale. However, the necessary maintenance effort of such a system is associated with considerable costs and is therefore to be evaluated as critical with regard to the associated operating costs. Therefore, this particular concept of downstream energy recovery is generally not pursued further at present. Innovative revisions of this concept must be tested in practice in the productive environment in the long term at great expense. However, this requires a certain willingness to take risks on the part of the companies, which, due to the fierce competition in this industry, is generally not taken.
https://en.wikipedia.org/wiki?curid=55785489
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Adverse effects have been poorly studied. The single systematic review of the literature did not report of the types and number of adverse events. In 2019, Health Canada stated that most autologous cell therapies have little evidence showing they work and can pose risks, such as cross-contamination between people if equipment is not sterilized properly or potentially dangerous immune reactions. Health Canada stopped Canadian clinics from offering these types of services with a donor-patient model. Health Canada later clarified that PRP treatments harvested from, and given back to, the same person (in a single procedure) was not covered by its initial guidance as the procedure falls under health care provider regulatory bodies (rather than Health Canada).
https://en.wikipedia.org/wiki?curid=22050188
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Box counting is a method of gathering data for analyzing complex patterns by breaking a dataset, object, image, etc. into smaller and smaller pieces, typically "box"-shaped, and analyzing the pieces at each smaller scale. The essence of the process has been compared to zooming in or out using optical or computer based methods to examine how observations of detail change with scale. In box counting, however, rather than changing the magnification or resolution of a lens, the investigator changes the size of the element used to inspect the object or pattern (see Figure 1). Computer based box counting algorithms have been applied to patterns in 1-, 2-, and 3-dimensional spaces. The technique is usually implemented in software for use on patterns extracted from digital media, although the fundamental method can be used to investigate some patterns physically. The technique arose out of and is used in fractal analysis. It also has application in related fields such as lacunarity and multifractal analysis.
https://en.wikipedia.org/wiki?curid=34552620
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Game theory is closely related to decision theory and the problem of rational choice. Rational choice is based on the idea that rational agents perform a cost-benefit analysis of all available options and choose the option that is most beneficial from their point of view. In the case of game theory, several agents are involved. This further complicates the situation since whether a given option is the best choice for one agent may depend on choices made by other agents. Game theory can be used to analyze various situations, like playing chess, firms competing for business, or animals fighting over prey. Rationality is a core assumption of game theory: it is assumed that each player chooses rationally based on what is most beneficial from their point of view. This way, the agent may be able to anticipate how others choose and what their best choice is relative to the behavior of the others. This often results in a Nash equilibrium, which constitutes a set of strategies, one for each player, where no player can improve their outcome by unilaterally changing their strategy.
https://en.wikipedia.org/wiki?curid=61032
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After the end of World War II, Akademia Lekarska was founded in Gdańsk. In 1950 its name was changed to Akademia Medyczna (The Medical University of Gdańsk). Among the professors of the newly established college, there were many eminent Polish scholars from the University of Stefan Batory in Vilnius, who had come to Gdańsk after Vilnius was incorporated into the Soviet Union, and a handful of scholars from other pre-war Polish academic centers. Initially, Akademia Lekarska conducted studies in two majors: medical and pharmaceutical. In May 1947 the Faculty of Stomatology was created and later on in January 1950 the name was changed to the Subfaculty of Dentistry at the Faculty of Medicine. In 1975 Medical University of Gdańsk (MUG) opened a branch in Bydgoszcz, which in 1984 became an independent college. In 1993, as a joint unit of Medical University of Gdańsk and Gdańsk University, the Intercollegiate Faculty of Biotechnology was founded. In the academic year 2005/2006 Medical University started the Faculty of Health Sciences. In 2016 works began on a Non-Invasive Medicine Centre at the University, with works set to be complete by the end of 2020.
https://en.wikipedia.org/wiki?curid=2613731
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Dutch draper and pioneering microbiologist Antonie van Leeuwenhoek (1632–1723), a contemporary of artist Vermeer (and an executor for Vermeer when he died in 1675) in Delft was known to have exceptional lens making skills, having created single small lenses capable of 200x magnification, far exceeding those of more complex compound microscopes of the period. Indeed, his feats of lens making were not matched for a considerable time as he kept aspects of their construction secret; in the 1950s, C.L. Stong used thin glass thread fusing instead of polishing to recreate Leeuwenhoek design microscopes. It was long believed that Antonie van Leeuwenhoek was a master lens grinder (a notion repeated in the recent BBC television documentary "Cell"). However, it is now believed that he came upon a relatively simple method of making small, high quality glass spheres by heating and manipulating a small rod of soda lime glass.
https://en.wikipedia.org/wiki?curid=10082768
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During the summer, a pre-production run of 10 Ju 88 B-0 based on the pre-production Ju 88 A-4 airframes were delivered. The A-4 used a longer wing of span from new rounded wingtips for better altitude performance, when compared to the initial Ju 88A-1's shorter span, but attention to streamlining and new pointed wing tips, somewhat resembling those fitted to the British Spitfire Mks.VII and VIII for their own intended high-altitude flight requirements, kept drag to about what it was earlier. The airframe changes moved the center of gravity slightly, so the glazed cockpit area was made slightly longer to re-balance the aircraft, while also offering better visibility for other members of the crew.
https://en.wikipedia.org/wiki?curid=188045
868,214
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In yeast, Osh4 is an OSBP homologue the crystal structure of which, obtained in both the sterol-bound and unbound states, showed a soluble β-barrel protein with a hydrophilic external surface and a hydrophobic pocket that can carry a single sterol molecule. Seven OSBP homologues (OSH proteins) have been identified in "Saccharomyces cerevisiae", in which their role has been suggested to be more relevant to sterol organization in the PM, rather than sterol trafficking from ER. Furthermore, Stefan et al. showed that OSH proteins control PI4P metabolism via the Sac1 Phosphatidylinositol (PI) 4-phosphatase. They also proposed a mechanism for Sac1 regulation: high Phosphatidylinositol 4-phosphate (PI4P) levels on the plasma membrane recruit Osh3 at PM-ER contact sites through its pleckstrin homology (PH) domain; Osh3 is now active and can interact with the ER-resident VAP proteins Scs2/Scs22 through its FFAT motif (two phenylalanines on an acidic tract), ultimately activating ER-localized Sac1 to reduce PI levels.
https://en.wikipedia.org/wiki?curid=21683238
1,579,353
1,605,398
While any plant can be a weed, approximately 250 plant species are sufficiently troublesome, cosmopolitan and economically injurious to warrant targeted research into their biology to assist in their management and control. Examples of some of these troublesome weed species in North America are Palmer amaranth ("Amaranthus palmeri S. Watson)", common lambsquarter ("Chenopodium album L."), horseweed ("Erigeron canadensis L.)", morningglory ("Ipomoea spp.)", waterhemp ("Amaranthus tuberculatus (Moq.) J. D. Sauer)" and common ragweed ("Ambrosia artemisiifolia L."). Some weed science researchers provide extension resources for farmers and land managers by trialing a variety of weed control tools and tactics on a specific weed, publishing the results and providing recommendations for their future management. Other researchers may study the biology of weed seeds in order to determine how long weed seeds can remain viable in a soil. Much of this research is conducted at public land-grant universities.
https://en.wikipedia.org/wiki?curid=53497560
1,604,494
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Weismann's work on the demarcation between germ-line and soma can scarcely be appreciated without considering the work of (mostly) German biologists during the second half of the 19th century. This was the time that the mechanisms of cell division began to be understood. Eduard Strasburger, Walther Flemming, Heinrich von Waldeyer and the Belgian Edouard Van Beneden laid the basis for the cytology and cytogenetics of the 20th century. Strasburger, the outstanding botanical physiologist of that century, coined the terms nucleoplasm and cytoplasm. He said "new cell nuclei can only arise from the division of other cell nuclei". Van Beneden discovered how chromosomes combined at meiosis, during the production of gametes, and discovered and named chromatin. Walther Flemming, the founder of cytogenetics, named mitosis, and pronounced "omnis nucleus e nucleo" (which means the same as Strasburger's dictum). The discovery of mitosis, meiosis and chromosomes is regarded as one of the 100 most important scientific discoveries of all times, and one of the 10 most important discoveries in cell biology.
https://en.wikipedia.org/wiki?curid=46846
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Reviews have indicated that most individuals diagnosed with bipolar disorder, but who are euthymic (not experiencing major depression or mania), do not show neuropsychological deficits on most tests. Meta-analyses have indicated, by averaging the variable findings of many studies, cognitive deficits on some measures of sustained attention, executive function and verbal memory, in terms of group averages. On some tests, functioning is superior; however, and sub-threshold mood states and psychiatric medications may account for some deficits. A 2010 study found that "excellent performance" at school at age 15–16 was associated in males with a higher rate of developing bipolar disorder, but so was the poorest performance. A 2005 study of young adult males found that poor performance on visuospatial tasks was associated with a higher rate of developing bipolar disorder, but so was high performance in arithmetic reasoning.
https://en.wikipedia.org/wiki?curid=30639411
1,873,774
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In 1999 Martill suggested that a climate change at the end of the Callovian led to the extinction of "Leedsichthys" in the northern seas, the southern Ocean offering a last refuge during the Oxfordian. However, in 2010 Liston pointed out that "Leedsichthys" during the later Kimmeridgian was still present in the north, as testified by Normandian finds. Liston did nevertheless consider in 2007 that the lack of any vertebrate suspension feeders as large as prior to the Callovian stage of the Mesozoicum might indicate that the Callovian had seen a marked change in productivity as regarded zooplankton populations. Indeed, further studies supported this, viewing "Leedsichthys" as the beginning of a long line of large (> in length) pachycormid suspension feeders that continued to flourish well into the Late Cretaceous, such as "Bonnerichthys" and "Rhinconichthys", and emphasising the convergent evolutionary paths taken by pachycormids and baleen whales.
https://en.wikipedia.org/wiki?curid=1987761
1,024,360
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In June 1994, Airbus announced its plan to develop its own very large airliner, designated as A3XX. Airbus considered several designs, including an unusual side-by-side combination of two fuselages from its A340, the largest Airbus jet at the time. The A3XX was pitted against the VLCT study and Boeing's own New Large Aircraft successor to the 747. In July 1995, the joint study with Boeing was abandoned, as Boeing's interest had declined due to analysis that such a product was unlikely to cover the projected $15 billion development cost. Despite the fact that only two airlines had expressed public interest in purchasing such a plane, Airbus was already pursuing its own large-plane project. Analysts suggested that Boeing would instead pursue stretching its 747 design, and that air travel was already moving away from the hub-and-spoke system that consolidated traffic into large planes, and toward more non-stop routes that could be served by smaller planes.
https://en.wikipedia.org/wiki?curid=181173
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Among 787 flight systems, a key change from traditional airliners is the electrical architecture. The architecture is bleedless and replaces bleed air with electrically powered compressors and four of six hydraulic power sources with electrically driven pumps while eliminating pneumatics and hydraulics from some subsystems, e.g. engine starters and brakes. Boeing says that this system extracts 35% less power from the engines, allowing increased thrust and improved fuel efficiency. Spoiler electromechanical actuators (SEMAs) control two of the seven spoiler pairs on each wing surface, providing roll control, air and ground speed brake, and droop capabilities similar to those provided by the hydraulic actuators used on the remaining spoiler surfaces. The SEMAs are controlled by electronic motor control units (EMCUs).
https://en.wikipedia.org/wiki?curid=307133
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Professional biology in Canada dates from the creation of departments of natural history, which included the study of biology, at the Universities of Toronto and McGill in 1854 and 1858 respectively. Government interest in biology was reflected in the establishment of the Experimental Farm Service in 1886 with Professor William Saunders as the first Director. A Central Experimental Farm was established in Ottawa that year as well as regional farms in Nappan, Nova Scotia in 1887, and Brandon, Manitoba, Indian Head, Northwest Territories and Agassiz, BC in 1888. A number of divisions for the study of topics of special interest to Canadian farmers were established including, entomology and botany, horticulture, chemistry, poultry, cereal, agriculture and tobacco.
https://en.wikipedia.org/wiki?curid=18401364
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The first functional imaging technique utilized in pheochromocytoma patients was I-MIBG scintigraphy (Image Right). Given the compounds similar structure to the catecholamine norepinephrine (secreted by pheochromocytomas), MIBG was well-suited for uptake by most neuroendocrine tumors. Furthermore, if a patient was found to be positive on an MIBG scan, they were eligible for MIBG treatment, offering additional avenues for those with widespread metastatic disease. However, further investigation revealed that while MIBG excelled with adrenal lesions, it was far less superior in patients with extra-adrenal paragangliomas, particularly with specific genetic variants like succinate dehydrogenase subunit X ("SDHx)." As the positron emission tomography scans were developed, MIBG has slowly loss its favor for the pheochromocytoma patient.
https://en.wikipedia.org/wiki?curid=277088
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Whenever there has been an absence of effective policy implementation, other players have stepped up to the plate to deliver knowledge transfer and technological absorption, including through public–private partnerships. Examples are the National Innovation Centre, created through crowdsourcing organized by individuals in 2012 and constructed on land donated by Tribhuvan University in 2019; the Centre for Molecular Dynamics Nepal (est. 2007), created through a non-governmental organization (NGO); and the Smart Urban Technology Challenge, a public–private partnership involving the Kathmandu municipality that organizes regular competitions for entrepreneurial teams to solve problems related to urban development.
https://en.wikipedia.org/wiki?curid=52027146
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This Centre received several research and development grants from the Secretary of Science and Technology of the University of Buenos Aires. At the Scientific Renewable Programming 2004–2007, they got a stipendium for the creation of a Mathematics & Design Laboratory MyD_Lab. This Laboratory was officially inaugurated on April 15, 2005 and its main aim is to act as a technological pole of support, assessor ship and training in the subjects referred to the application of mathematical and informatical methodologies so as to state, develop and solve in an optimal way applied problems. The research lines in development are the following
https://en.wikipedia.org/wiki?curid=14064719
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Pumped-storage hydroelectricity (PSH), or pumped hydroelectric energy storage (PHES), is a type of hydroelectric energy storage used by electric power systems for load balancing. The method stores energy in the form of gravitational potential energy of water, pumped from a lower elevation reservoir to a higher elevation. Low-cost surplus off-peak electric power is typically used to run the pumps. During periods of high electrical demand, the stored water is released through turbines to produce electric power. Although the losses of the pumping process make the plant a net consumer of energy overall, the system increases revenue by selling more electricity during periods of peak demand, when electricity prices are highest. If the upper lake collects significant rainfall or is fed by a river then the plant may be a net energy producer in the manner of a traditional hydroelectric plant.
https://en.wikipedia.org/wiki?curid=277237
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In 1988, Martin Ralph and Menaker serendipitously came across a tau mutant male golden hamster in a shipment from their commercial supplier, Charles River Laboratories, that was observed to have a circadian period significantly shorter than what is characteristic of that breed. These golden hamsters are recognized for their narrow range of periods with a typical mean of 24 hours. Thus, rather than overlooking this abnormal male hamster, Menaker conducted breeding experiments to produce homozygous tau mutants with a period of 20 hours and heterozygous tau mutants with a period of 22 hours. The pattern of inheritance from this shortened tau indicated the genetic cause of this phenotype was isolated to a single allele, providing a genetic approach to the determination of the biological mechanism. This accidental forward genetic screen yielded the first specimen that could be studied for genetic insight into mammalian circadian mechanisms.
https://en.wikipedia.org/wiki?curid=39100385
2,151,899
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The Decca Navigation System was originally developed in the US, but eventually deployed by the Decca Radio company in the UK and commonly referred to as a British system. Initially developed for the Royal Navy as an accurate adjunct to naval versions of Gee, Decca was first used on 5 June 1944 to guide minesweepers in preparation for the D-Day invasions. The system was developed post-war and competed with GEE and other systems for civilian use. A variety of reasons, notably its ease-of-use, kept it in widespread use into the 1990s, with a total 42 chains around the world. A number of stations were updated in the 1990s, but the widespread use of GPS led to Decca being turned off at midnight on 31 March 2000.
https://en.wikipedia.org/wiki?curid=33739081
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Preference of early scholars towards the use of the Syrian/Syriac label was also relied upon its notable use as an alternative designation for Aramaic language in the ""Cave of Treasures"", long held to be the 4th century work of an authoritative writer and revered Christian saint Ephrem of Edessa (d. 373), who was thus believed to be proponent of various linguistic notions and tendencies expressed in the mentioned work. Since modern scholarly analyses have shown that the work in question was written much later ( 600) by an unknown author, several questions had to be reexamined. In regard to the scope and usage of Syrian/Syriac labels in linguistic terminology, some modern scholars have noted that diversity of Aramaic dialects in the wider historical region of Syria should not be overlooked by improper and unspecific use of Syrian/Syriac labels.
https://en.wikipedia.org/wiki?curid=59412
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Symptoms of an infection of "P. oryzihabitans" are actually quite vague and similar to the signs that can indicate other illnesses or diseases, so it is relatively difficult to identify when only looking at symptoms. However, in several cases, these infections result after an individual's immune system has been weakened, so it is likely to occur in recovering or ill patients. Most patients, after receiving treatment for another disease or during recovery from surgery, experience chills and increase in body temperature. While these symptoms could mean a variety of things, it is clear that the patient's recovery is halted and that there is an infection of some sort. In an example where a woman developed an infection of "P. oryzihabitans" from a case of sinusitis, she experienced the same chills and elevated temperature, but also nasal discharge containing pus, right facial pain, and a fever.
https://en.wikipedia.org/wiki?curid=10330881
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One method to reduce the rate of PUFA oxidation is to replace a portion of the dietary PUFAs with reinforced PUFAs of identical chemical structure to natural PUFA, but more resistant to oxidation. Those hydrogen atoms that are most prone to oxidation are replaced with deuterium atoms. This change has no discernible impact on the normal biochemical properties of D-PUFAs – their distribution within the human body remains unchanged, they undergo all the normal enzyme catalysed PUFA reactions, they function normally in all cell and organelle membranes, but once the levels of these D-PUFAs in various membranes reach a concentration of about 15-20%, all non-enzymatic chain oxidation stops including that of the normal, nondeuterated PUFAs. The result is the stabilization of cell membranes, even in the face of excess oxidative stress or diminished membrane repair, such as those elicited by disease states.
https://en.wikipedia.org/wiki?curid=66508692
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The Sun is a G-type main-sequence star (G2V). As such, it is informally, and not completely accurately, referred to as a yellow dwarf (its light is actually white). It formed approximately 4.6 billion years ago from the gravitational collapse of matter within a region of a large molecular cloud. Most of this matter gathered in the center, whereas the rest flattened into an orbiting disk that became the Solar System. The central mass became so hot and dense that it eventually initiated nuclear fusion in its core. It is thought that almost all stars form by this process.
https://en.wikipedia.org/wiki?curid=26751
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The U.S. Army, after berating the South Vietnamese for flouting battle doctrine, came out with their own ACAV version. This more or less standardized ACAV kit included shields and a circular turret for the .50-caliber M2 machine gun in the track commander (TC) position, two M60 machine guns with shields for the left and right rear positions, and "belly armor"—steel armor bolted from the front bottom extending 1/2 to 2/3 of the way towards the bottom rear of the M113. The two rear machine gunners could fire their weapons while standing inside the rectangular open cargo hatch. This transformed the M113 into a fighting vehicle, but the vehicle still suffered from its lightly armored configuration, having never been designed for such a role. Canada also adopted the ACAV kits when employing the M113A2 during peacekeeping operations in the Balkans in the 1990s.
https://en.wikipedia.org/wiki?curid=449687
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In spite of the many Canadians in military aviation, the Canadian government had shown little interest or ability to organize its own air force. Canadian politicians made no attempt to fund flight training, aircraft purchase, or construction of airfields. The Canadian Aviation Corps, with only three members, was founded in 1914 by Sir Sam Hughes, but was an inept and ineffective false start, never flying in combat and with its sole aircraft abandoned after a few months. A Canadian Air Force was established in 1918, but it was disbanded shortly after the end of the war. Not until 1920 was a permanent air force established. Canadians seeking flight training, aside from a few who entered schools at Toronto and Vancouver, either had to travel to enlist in French or British air forces, or received training when the RAF set up schools in Canada in 1917.
https://en.wikipedia.org/wiki?curid=33486410
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The name "Tiktaalik" is an Inuktitut word meaning "large freshwater fish". The "fishapod" genus received this name after a suggestion by Inuit elders of Canada's Nunavut Territory, where the fossil was discovered. The specific name "roseae" cryptically honours an anonymous donor. Taking a detailed look at the internal head skeleton of "Tiktaalik roseae", in the October 16, 2008, issue of "Nature", researchers show how "Tiktaalik" was gaining structures that could allow it to support itself on solid ground and breathe air, a key intermediate step in the transformation of the skull that accompanied the shift to life on land by our distant ancestors.
https://en.wikipedia.org/wiki?curid=4639256
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Grant O. Gale Observatory is an astronomical observatory owned and operated by Grinnell College Department of Physics. The observatory is located in Grinnell, Iowa (USA). Constructed in 1984, it is named after Grant O. Gale, a distinguished teacher and curator of the Grinnell Physics Historical Museum. Designed by Woodburn and O'Neil of Des Moines, the building is a 38-foot by 55-foot structure rising 26 feet to the top of the dome. It houses a 24-inch Cassegrain reflecting telescope built by DFM Engineering of Longmont, Colorado. The observatory houses two computer systems: the first controls the telescope and the second accommodates data acquisition and analysis and can be used to store television images. In addition to its primary function as an instructional and research tool, the observatory is also a facility for public viewing of astronomical phenomena under staff supervision.
https://en.wikipedia.org/wiki?curid=3049485
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The entomological collections are primarily housed at the National Museum of Natural History in downtown Washington, D.C. (70%), the NMNH Museum Support Center (MSC) in Suitland, Maryland (20%), and the Beltsville Agricultural Research Center (BARC) in Beltsville, Maryland (10%). The collections are loaned to qualified scientists and students around the world, and the department hosts visiting scientists who come to study the collections on-site. The department also houses the Entomology Illustration Archives, approximately 6000 illustrations originally created to support the department's research and publications but now housed and conserved separately as historically significant art objects. Recently, the Department of Entomology has also established a non-illustration archive for physical objects, field and laboratory research notebooks and materials, and for correspondence of entomology researchers and staff based at the NMNH from all three agencies, as well as similar items accompanying donated collections.
https://en.wikipedia.org/wiki?curid=39216233
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Dung flies are a polygamous species that mate on cowpats. The copulation behavior of this species can also be modeled using the marginal value theorem. It has been discovered that in cases where two male dung flies copulate with the same female in relatively rapid succession, the second male will fertilize 80% of the eggs, while the first male will only fertilize 20%. This creates a dilemma for male dung flies. The longer they remain with a female after copulation, the better they are able to guard her from copulating with other males, hence increasing the likelihood of passing his genes to her offspring. However, the longer the male remains with an individual female, the smaller chance he has of finding other mates. Geoff Parker predicted that an optimality model comparing these two behaviors would be affected by the travel time between two patches. For example, short distances between cowpats should widen the pool of available mates in a specific geographic location. Parker predicted that under this condition, dung flies would be more likely to leave their current mate sooner to find additional mates. But if cowpats are few and far between, it would benefit a male dung fly to spend more time guarding a mate, ensuring his genes are passed on, because he may have difficulty finding an additional mate. The results from Parker's experiment agree with this model.
https://en.wikipedia.org/wiki?curid=37551669
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Every laser beam wanders and jitters — albeit a small amount. The typical kinematic tip-tilt mount drifts by around 100 μrad per day in a laboratory environment (vibration isolation via optical table, constant temperature and pressure, and no sunlight that causes parts to heat). A laser beam incident upon this mirror will be translated by 100 m at a range of 1000 km. This could make the difference between hitting or not hitting a communications satellite from Earth. Hence, there is a lot of interest in characterizing the beam wander (slow time scale) or jitter (fast time scale) of a laser beam. The beam wander and jitter can be measured by tracking the centroid or peak of the beam on a CCD beam profiler. The CCD frame rate is typically 30 frames per second and therefore can capture beam jitter that is slower than 30 Hz — it can't see fast vibrations due to one's voice, 60 Hz fan motor hum, or other sources of fast vibrations. Fortunately, this is usually not a great concern for most laboratory laser systems and the frame rates of CCDs are fast enough to capture the beam wander over the bandwidth that contains the greatest noise power. A typical beam wander measurement involves tracking the centroid of the beam over several minutes. The rms deviation of the centroid data gives a clear picture of the laser beam pointing stability. The integration time of the beam jitter measurement should always accompany the computed rms value. Even though the pixel resolution of a camera may be several micrometres, sub-pixel centroid resolution (possibly tens of nanometer resolution) is attained when the signal-to-noise ratio is good and the beam fills most of the CCD active area.
https://en.wikipedia.org/wiki?curid=15267398
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A centrifuge is a device that uses centrifugal force to separate various components of a fluid. This is achieved by spinning the fluid at high speed within a container, thereby separating fluids of different densities (e.g. cream from milk) or liquids from solids. It works by causing denser substances and particles to move outward in the radial direction. At the same time, objects that are less dense are displaced and moved to the centre. In a laboratory centrifuge that uses sample tubes, the radial acceleration causes denser particles to settle to the bottom of the tube, while low-density substances rise to the top. A centrifuge can be a very effective filter that separates contaminants from the main body of fluid.
https://en.wikipedia.org/wiki?curid=106284
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Even though combinatorial chemistry has been an essential part of early drug discovery for more than two decades, so far only one de novo combinatorial chemistry-synthesized chemical has been approved for clinical use by FDA (sorafenib, a multikinase inhibitor indicated for advanced renal cancer). The analysis of the poor success rate of the approach has been suggested to connect with the rather limited chemical space covered by products of combinatorial chemistry. When comparing the properties of compounds in combinatorial chemistry libraries to those of approved drugs and natural products, Feher and Schmidt noted that combinatorial chemistry libraries suffer particularly from the lack of chirality, as well as structure rigidity, both of which are widely regarded as drug-like properties. Even though natural product drug discovery has not probably been the most fashionable trend in the pharmaceutical industry in recent times, a large proportion of new chemical entities still are nature-derived compounds, and thus, it has been suggested that effectiveness of combinatorial chemistry could be improved by enhancing the chemical diversity of screening libraries. As chirality and rigidity are the two most important features distinguishing approved drugs and natural products from compounds in combinatorial chemistry libraries, these are the two issues emphasized in so-called diversity oriented libraries, i.e. compound collections that aim at coverage of the chemical space, instead of just huge numbers of compounds.
https://en.wikipedia.org/wiki?curid=36680
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Sherman exploited the yeast cytochrome c system to investigate nearly every stage and regulatory mechanism in gene expression including: 1) Identification of critical DNA sequences that control transcription initiation and termination; 2) Identification of mechanisms of RNA processing and degradation; 3) Identification of the roles of RNA sequences that control initiation of translation; 4) Isolation of "nonsense suppressor" mutations in tRNA genes and protein-coding genes that cause read-through at nonsense (stop) codons, thereby preventing termination of protein synthesis; 5) Identification of mechanisms of intracellular trafficking of cytochrome "c" to mitochondria; 6) Identification of mutations affecting protein folding and stability; 7) Detection of the effects of chaperones on protein stability; 8) Characterization of the roles of post-translational modifications of proteins such as methylation, acetylation, ubiquitination, N-terminal proteolytic processing, and covalent attachment of heme; 9) Identification of mechanisms of protein degradation in mitochondria; 10) Understanding the roles of various mitochondrial proteins in bioenergetics and metabolic processes; and Batten disease (together with D. Pearce).
https://en.wikipedia.org/wiki?curid=41010273
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Since the discovery of ENAs, they have been used as a diagnostic tool in connective tissue disease. Two widely used gel-based techniques were used to identify anti-ENAs and their associations to disease in early work, double immunodiffusion (DID) and counterimmunoelectrophoresis (CIEP). Both of these techniques require the precipitation of antigens for valid results. Depending on the anit-ENA being investigated, one technique may be used over the other. For example, Scl-70 antigen is less negatively charged, which can result in the antigen traveling in the same direction as the antibody. This would result in the antibody-antigen complex not precipitating; leading to invalid results. In addition, some anti-SS-B antibodies commonly identified in Sjögren syndrome may not be detected with this method. However, this method is economically feasible and specific to confirm a diagnosis. There are two sensitivities to note when viewing data from these gel-based techniques, assay sensitivity and disease sensitivity. Assay sensitivity is the ability to recognize when an antibody is present, while disease sensitivity is the ability to recognize the frequency in which the antibody occurs in a disease. Due to limitations of gel-based techniques in disease sensitivity, other techniques have been explored in order to increase assay sensitivity without decreasing disease sensitivity. For example, in patients with Systemic lupus erythematous (SLE), only 8–40% have detectable anti-SM when using gel-based assays. CIEP has been shown to be more sensitive than DID.
https://en.wikipedia.org/wiki?curid=4948393
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Founded in 1917 as Deep Springs, Collegiate and Preparatory, it was originally a men's college backed by funding from L. L. Nunn, a lawyer and businessman. He envisioned a form of education that combined academic rigor, manual labor, and self-governance—an unorthodox combination at the time. Located in a geological depression inside the Sierra Mountains, its campus is situated within a cattle ranch with the aim of providing a secluded environment away from urban life so undergraduates may focus on their studies and leadership ability. The college is primarily maintained and self-governed by students, becoming a coeducational institution in 2018.
https://en.wikipedia.org/wiki?curid=353345
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In general, it can be said that experimental infections in humans are tightly linked to a history of scandals in medical research, with scandals being followed by stricter regulatory rules. Ethical guidelines that govern the use of human subjects in research are a fairly new construct. In 1906 some regulations were put in place in the United States to protect subjects from abuses. After the passage of the Pure Food and Drug Act in 1906, regulatory bodies such as the Food and Drug Administration (FDA) and institutional review boards (IRBs) were gradually introduced. The policies that these institutions implemented served to minimize harm to the participant's mental and/or physical well-being.
https://en.wikipedia.org/wiki?curid=447842
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More than 116,000 members of the U.S. military died in the war, far fewer than combatants from other countries. No one has estimated how many orphans resulted. Additionally, as the male workforce left for battle, mothers and sisters began working in factories to take their positions, and the family dynamic began to change; this affected children as they had less time to spend with family members and were expected to grow up faster and help with the war effort. Similarly, Woodrow Wilson called on children involved in youth organizations to help collect money for war bonds and stamps in order to raise money for the war effort. This was a way to mobilize public opinion and shame adults who did not donate. The Office of War Information and other agencies implemented programs and created posters and pamphlets to encourage war support.
https://en.wikipedia.org/wiki?curid=26048493
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First, there is the panoramic, one of the four single-wall exposure/single-wall view (SWE/SWV) arrangements. This exposure is created when the radiographer places the source of radiation at the center of a sphere, cone, or cylinder (including tanks, vessels, and piping). Depending upon client requirements, the radiographer would then place film cassettes on the outside of the surface to be examined. This exposure arrangement is nearly ideal – when properly arranged and exposed, all portions of all exposed film will be of the same approximate density. It also has the advantage of taking less time than other arrangements since the source must only penetrate the total wall thickness (WT) once and must only travel the radius of the inspection item, not its full diameter. The major disadvantage of the panoramic is that it may be impractical to reach the center of the item (enclosed pipe) or the source may be too weak to perform in this arrangement (large vessels or tanks).
https://en.wikipedia.org/wiki?curid=6856520
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Adaptive design is a broad approach to web design that focuses on suitability for a variety of interfaces rather than restricting itself to the format intended for a desktop display. This is especially significant in 2018 when smartphone search volumes have overtaken desktop search volumes in 10 countries, even with tablet searches counted in the desktop category. New technologies have emerged, bringing change to the face of web design as a whole and breathing new life into dynamic graphical web design. Note that, although dynamic web practices been around for more than two decades, dynamic design in reference to graphical layout, particularly for mobile device viewing, is a much more recent concept. It is also important, when defining the difference between RWD (responsive web design) and AWD (adaptive web design), that new technologies (such as CSS3 Media Queries, AJAX, HTML5, near universal JS integration, etc.) have centered around RWD- not AWD, which is typically more efficient and effective than AWD. AWD only exists in new design to supplement RWD where RWD technologies cannot be properly interpreted by the browser (in the case of "non-smart" mobile device browsers and outdated smartphones). These recent changes (the transition from desktop to mobile) make fluid mobile design one of the most important concepts in graphical web development and have led to a strong transition to RWD and away from AWD.
https://en.wikipedia.org/wiki?curid=39594074
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The ascetic practices of total renunciation of worldly affairs and possessions, refusal to stay in a single place for a long time, continuous practice of austerities like fasting etc. are geared towards observance of . The Jain mendicants abide by a rigorous set of rules of conduct, where they must eat, sleep and even walk with full diligence and with an awareness that even walking kills several hundreds of minute beings. Jain ascetics sweep the ground before them to avoid injuring the most minuscule forms of life. They generally brush the ground clear of insects before they tread. Digambara monks do not wear any clothes and eat food only when it is not prepared for themselves. Ascetics of the Śvētāmbara tradition wear a small mask to avoid taking in tiny insects. The observation of three or the controls of mind, speech and body and five "samiti" are designed to help the monks in observing the vow of Ahimsa faultlessly. A monk is required to cultivate the habit of carefulness ("samti"), in respect of the following five particulars:-
https://en.wikipedia.org/wiki?curid=13323241
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To measure this electrical difference precisely, Pauling assigned graduate student John Singer to work with Itano and another medical researcher, Ibert C. Wells, before Pauling left in early 1948 for a guest lectureship in England. Using a "Tiselius Apparatus" to perform free-boundary electrophoresis, Pauling's three researchers were able to estimate that molecules of sickle-cell hemoglobin had about three more positive charges than normal hemoglobin. They also estimated that blood from those with sickle cell trait was a mixture of 60 percent normal hemoglobin and 40 percent sickle-cell hemoglobin. Near the end of the project, they learned of parallel results by geneticist James V. Neel, who demonstrated the inheritance pattern of the disease by traditional genetic methods; both Neel's work and that of Pauling's group were published in the same issue of "Science".
https://en.wikipedia.org/wiki?curid=20815897
1,513,307
537,427
Until recently, it was thought that all species lived in the sediment on the seabed, subsisting as deposit feeders or suspension feeders. However, the early 21st century has seen the description of a new family, the Torquaratoridae, evidently limited to the deep sea, in which most of the species crawl on the surface of the ocean bottom and alternatively rise into the water column, evidently to drift to new foraging sites. It is assumed that the ancestors of acorn worms used to live in tubes like their relatives Pterobranchia, but that they eventually started to live a safer and more sheltered existence in sediment burrows instead. The body length normally range from to (Balanoglossus gigas), but one species, Meioglossus psammophilus, only reach . Due to secretions containing elements like iodine, the animals have an iodoform-like smell.
https://en.wikipedia.org/wiki?curid=1790775
537,148
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The magnetic field is highly variable from −2,300 to +3,100 gauss, matching the brightness variations and the likely rotational period. This requires a magnetic dipole of at least 10,000 G. Around minimum brightness, a shell type spectrum appears, attributed to plasma clouds rotating above the photosphere. The helium enhancement in the spectrum may be due to hydrogen being preferentially trapped towards the magnetic poles leaving excess helium near the equator. It was at one point suggested that σ Ori E could be further away and older than the other members of the cluster, from modelling its evolutionary age and size. However, "Gaia" parallaxes place σ Ori E within the cluster, and later modelling has suggested that it is very young, at less than a million years old.
https://en.wikipedia.org/wiki?curid=3991369
1,406,579
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From 2007 to 2014 UNSW Business School was ranked by the "Financial Times" as having the best full-time MBA program in the country. The school's primary undergraduate degree, the Bachelor of Commerce, has the highest Australian high school entry score for a business undergraduate program in Australia. The 2022 QS World University Rankings ranked UNSW 20th in the World for Accounting and Finance (1st in Australia). In the 2022 ARWU Global Academic Subject Rankings UNSW is ranked 29th in the World for Finance (1st in Australia) and 51-75th in the World for Management. In the 2022 University Ranking by Academic Performance, UNSW is ranked 10th in the world for Commerce, Management, Tourism and Services and 18th globally for Business. In 2022 SCImago Institutions Rankings UNSW is ranked 11th in the World for Business, Management and Accounting and 33rd the World for Economics, Econometrics and Finance. According to latest 2021 KUBS worldwide business research rankings, UNSW is ranked 1st worldwide for Finance and 27th globally for Management. In the 2021 CFAR Rankings by Olin Business School at Washington University in St. Louis, UNSW is ranked 16th in the World for Finance and 9th in the World for Business by Total Outcome/Output indicator of research excellence The 2019 "Apollo Communications Australian Top 50 CEO Report" found that UNSW has educated more CEOs of Australia's top 50 companies than any other university in Australia and has produced more technology entrepreneurs in the past 20 years than any other Australian university, and has the largest number of millionaire alumni of any other university in Australia.
https://en.wikipedia.org/wiki?curid=16766976
1,488,265
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The Buran orbital vehicle program was developed in response to the U.S. Space Shuttle program, which in the 1980s raised considerable concerns among the Soviet military and especially Defense Minister Dmitry Ustinov. An authoritative chronicler of the Soviet and later Russian space programs, the academic Boris Chertok, recounts how the program came into being. According to Chertok, after the U.S. developed its Space Shuttle program, the Soviet military became suspicious that it could be used for military purposes, due to its enormous payload, several times that of previous U.S. launch vehicles. The Soviet government asked the TsNIIMash (, a major player in defence analysis) for an expert opinion. Lieutenant General Yuri Mozzhorin recalled that by "approximately 1965", when the Soviet Union had the 'long arm' (ICBMs), the Soviets did not expect war "and thought it would not happen." As institute director, Mozzhorin, recalled that for a long time the institute could not envisage a civilian payload large enough to require a vehicle of that capacity.
https://en.wikipedia.org/wiki?curid=36716
182,588
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Mallinckrodt Incorporated in St. Louis, Missouri, took the raw ore and dissolved it in nitric acid to produce uranyl nitrate. Ether was then added in a liquid–liquid extraction process to separate the impurities from the uranyl nitrate. This was then heated to form uranium trioxide, which was reduced to highly pure uranium dioxide. By July 1942, Mallinckrodt was producing a ton of highly pure oxide a day, but turning this into uranium metal initially proved more difficult for contractors Westinghouse and Metal Hydrides. Production was too slow and quality was unacceptably low. A special branch of the Metallurgical Laboratory was established at Iowa State College in Ames, Iowa, under Frank Spedding to investigate alternatives. This became known as the Ames Project, and its Ames process became available in 1943.
https://en.wikipedia.org/wiki?curid=19603
10,049
1,261,979
Epoxy putty refers to a group of room-temperature-hardening substances used as space-filling adhesives. Exact compositions vary according to manufacturer and application. They are stored until used as two components of clay-like consistency. Kneading the two components into each other creates an exothermic chemical reaction that activates the substance for use by catalyzing an epoxide polymerisation reaction. Unlike many other types of glues, an epoxy adhesive can fill gaps and even be molded into a structural part. Some makers claim in advertising that one can drill and tap their cured products and that they quickly cure "hard as steel" (as measured by Shore rating), though they are much weaker than steel in tensile strength and shear strength.
https://en.wikipedia.org/wiki?curid=21490478
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In this program, complex systems and network theory was applied to economics and business to understand how evolutionary change occurs. Multi-agent modelling and associated simulation and calibration techniques were core components of the methodology used. We investigated new ways of testing for complex patterns in high frequency data, by studying trade-by trade data in stock markets and in electricity markets and seeking 'pattern matches' in artificially generated agent-based modelling data. We investigated new ways of dealing with spatial complexity in several contexts. Also visualisation techniques, rarely used in economics, were applied in a range of data-rich contexts to better understand the architecture and complex dynamics of systems.
https://en.wikipedia.org/wiki?curid=23623750
2,097,475
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Although originally thought to have the exact same mechanism as the "Renilla" luciferase [1], this luminescence has two possible reaction routes [2], as shown in figure 3. In the top route, "Oplophorus luciferin" (the coelenterazine displayed as I in the scheme) is oxidized when it combines with O2(radioactively labelled O18 was used in lab experiment) in a water medium and uses a dioxetane peroxide intermediate resulting in a product and coelenteramide (II in the scheme). The lower pathway does not use an intermediate and has rapid exchanges of oxygen with the water medium. Studies show there is less product yield and is suggested to have partial involvement in the overall reaction [2]. It should be noted, however, it is likely contamination during experiments demonstrated higher yield than was occurring for the lower pathway, making this pathway highly unlikely in natural conditions [2].
https://en.wikipedia.org/wiki?curid=14144383
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Another primitive technique of attacking submarines was the dropping of hand-thrown guncotton bombs. The Lance Bomb was developed, also; this featured a cone-shaped steel drum on a shaft, intended to be thrown at a submarine. Firing Lyddite shells, or using trench mortars, was tried. Use of nets to ensnare U-boats was also examined, as was a destroyer, , fitted with a spar torpedo. To attack at set depths, aircraft bombs were attached to lanyards which would trigger their charges; a similar idea was a guncotton charge in a lanyarded can; two of these lashed together became known as the Depth Charge Type A. Problems with the lanyards tangling and failing to function led to the development of a chemical pellet trigger as the Type B. These were effective at a distance of around .
https://en.wikipedia.org/wiki?curid=3480866
277,560
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In December 1941 Admiral Ben Moreell proposed the creation of 3 Naval Construction Battalions. A problem then confronted BuDocks, who would command the Construction Battalions? Naval regulations stated that military command of naval personnel was strictly limited to line officers, yet BuDocks deemed it essential that these Construction Battalions be commanded by officers of the Civil Engineer Corp, who were trained in the skills required for construction work. The newly formed Bureau of Naval Personnel (BuPers), successor to the Navy's Bureau of Navigation, strongly opposed this transgression of Naval tradition. Admiral Moreell took the question personally to the Secretary of the Navy, Frank Knox, who, on 19 March 1942, gave authority for officers of the Civil Engineer Corps to exercise military authority over all officers and enlisted men assigned to construction units otherwise known as the Seabees. For those engineers assigned to the Seabees a silver Seabee was mounted to the center of the CEC crossed oak leaves insignia. The Seabee logo incorporated the CEC insignia, with one on each arm of the Seabee, just above each glove.
https://en.wikipedia.org/wiki?curid=7197000
1,114,407
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The energy difference between the "m" = 0 and "m" = ±1 states corresponds to the microwave regime. Population can be transferred between the states by applying a resonant magnetic field perpendicular to the defect axis. Numerous dynamic effects (spin echo, Rabi oscillations, etc.) can be exploited by applying a carefully designed sequence of microwave pulses. Such protocols are rather important for the practical realization of quantum computers. By manipulating the population, it is possible to out the NV center into a more sensitive or stable state. Its own resulting fluctuating fields may also be used to influence the surrounding nuclei or protect the NV center itself from noise. This is typically done using a wire loop (microwave antenna) which creates an oscillating magnetic field.
https://en.wikipedia.org/wiki?curid=14461309
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The 1977 legislation, either despite or because of its language, did not expressly allow WASPs to be buried in Arlington National Cemetery. That was because Arlington National Cemetery, unlike most other national cemeteries, is administered by the Department of the Army, not the Department of Veterans Affairs, and thus the Secretary of the Army determines eligibility for Arlington burial. The reason for the position taken by the Army on this issue may have been the rapidly diminishing space at Arlington. But in 2002, the Army re-considered and decided that deceased WASPs were able to be buried in Arlington National Cemetery. In 2015, however, the Army re-interpreted the law and its own regulations against the backdrop of thirteen years of war, which once again threatened to deplete the cemetery of land. The Army ruled that the 1977 statute did not mandate the burial of deceased WASPs at Arlington. When WASP, Elaine Harmon, died on April 21, 2015, her request to have her ashes interred at Arlington was denied. Another WASP, Florence Shutsy-Reynolds, began a social media campaign to advocate for Harmon and other WASP members who wished to be interred at Arlington. Legislation in 2016 seemingly overruled the Army's interpretation and it was widely reported that WASPs could "again" be buried at Arlington. The 2016 law revived the long-held concern about limited space at the cemetery. Thus, the legislation in the 114th Congress (S.2437 by Sen. Barbara Mikulski (D-Maryland) and H.R. 4336 by Rep. Martha McSally (R-Arizona), a retired Air Force fighter pilot), provides only for interment of cremated remains and not ground burial.
https://en.wikipedia.org/wiki?curid=1549788
904,647
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Saliency of a feature facilitates the ease with which it can be indexed. For example, the greater the difference between a specific feature and surrounding ones, the more easily it can be indexed. The indexed features, or anchor points, can serve as a "spotlight" that directs focal attention to certain objects, which can then channel visual information to specialized systems for space and shape analysis. Deficits in the spatial indexing mechanism would result in symptoms of simultanagnosia because interpretation of a complex scene requires rapid shifting of attention to various elements, and impairments in spatial indexing lead to the inability to index multiple visual features rapidly. In addition, perception is slowed, and low-level visual processing is disrupted since the patient would not be able to extract and index salient features.
https://en.wikipedia.org/wiki?curid=1616390
1,304,520
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Studies on children show that the average child is at greater risk for memory loss, due to the brain's immaturity and plasticity, when compared to an average adult. Poorer memory performance in young kids was shown when youth of different ages were asked to recall a doctor's visit. Children aged 3–5 answered with much less accuracy than individuals aged 6–15, indicating developmental differences in memory capacity. Furthermore, it has been shown that information encoded and stored in memory is dependent on the extent of knowledge regarding the event. That is, if a child is exposed to an event that he or she knows little about, their memory of the event will not be as accurate when compared to a child who is more knowledgeable on event-related topics. These results of increased sensitivity, suggestibility and memory loss in children lead one to question the competency of a child to serve as an eyewitness. Researchers have determined that a child should be considered a competent witness if he or she has the capacity to observe, communicate, produce sufficient memories, differentiate truth from lies, and understand the obligation to tell the truth. However, the same caution that is taken with all eyewitnesses should be taken with child testimony, as all eyewitness testimonies are prone to inaccuracies.
https://en.wikipedia.org/wiki?curid=33106906
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The impact of sickle cell trait on malaria immunity illustrates some evolutionary trade-offs that have occurred because of endemic malaria. Sickle cell trait causes a change in the haemoglobin molecule in the blood. Normally, red blood cells have a very flexible, biconcave shape that allows them to move through narrow capillaries; however, when the modified haemoglobin S molecules are exposed to low amounts of oxygen, or crowd together due to dehydration, they can stick together forming strands that cause the cell to distort into a curved sickle shape. In these strands, the molecule is not as effective in taking or releasing oxygen, and the cell is not flexible enough to circulate freely. In the early stages of malaria, the parasite can cause infected red cells to sickle, and so they are removed from circulation sooner. This reduces the frequency with which malaria parasites complete their life cycle in the cell. Individuals who are homozygous (with two copies of the abnormal haemoglobin beta allele) have sickle-cell anaemia, while those who are heterozygous (with one abnormal allele and one normal allele) experience resistance to malaria without severe anaemia. Although the shorter life expectancy for those with the homozygous condition would tend to disfavour the trait's survival, the trait is preserved in malaria-prone regions because of the benefits provided by the heterozygous form.
https://en.wikipedia.org/wiki?curid=20423
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During the Communist takeover of mainland China, when he was only a few months old, his family moved to Hong Kong where he was forced to learn to speak the Cantonese language as well as speak Chinese Hakka. He was not able to revisit until 1979, at the invitation of Hua Luogeng, when mainland China entered the reform and opening era.. They had financial troubles from having lost all of their possessions, and his father and second-oldest sister died when he was thirteen. Yau began to read and appreciate his father's books, and became more devoted to schoolwork. After graduating from Pui Ching Middle School, he studied mathematics at the Chinese University of Hong Kong from 1966 to 1969, without receiving a degree due to graduating early. He left his textbooks with his younger brother, Stephen Shing-Toung Yau, who then decided to major in mathematics as well.
https://en.wikipedia.org/wiki?curid=303137
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He was admitted to Pripyat Hospital but was quickly transferred to Moscow Hospital 6. By 28 April, the symptoms of radiation sickness had mostly worn away. His wife visited him in hospital and while aware he might not survive, he told her that he would give up working in the nuclear industry. During his stay, he discussed possible causes of the accident with Toptunov and Dyatlov but they were mystified. Toptunov and Akimov received a bone marrow transplant in an attempt to restore their immune systems. Akimov's condition quickly worsened. By the time accident investigator Sergei Yankovsky questioned him, Akimov could barely speak and was not able to provide much more information. Akimov eventually succumbed to acute radiation syndrome two weeks after the disaster at the age of 33. His family was informed that his death was the only reason he was not prosecuted for the accident.
https://en.wikipedia.org/wiki?curid=4854766
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Sports analytics have had significant impact on the field of play but sports analytics have also contributed to the growing industry of sports gambling, which accounts for approximately 13% of the global gambling industry. Valued somewhere between $700-$1,000 billion, sports gambling is extremely popular among groups of all kinds, from avid sports fans to recreational gamblers, you would be hard pressed to find a professional sporting event with nothing riding on the results. Many gamblers are attracted to sports gambling because of the plethora of information and analytics that are at their disposal when making decisions. One gambler, Bob Stoll, has been ahead of the analytics curve for a number of years, successfully betting against the line 56% (575–453) of the time in college football, a significant rate as a winning percentage above 52.4% is considered profitable. With the number of statistics so openly available to fans, Stoll combines a number of different statistics such as, home and away records, record vs divisional/non-divisional teams, rush yards per rush, etc., to make educated picks that have paid off more than half of the time.
https://en.wikipedia.org/wiki?curid=51589225
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During hydrostatic burning these fuels synthesize overwhelmingly the alpha nuclides (), nuclei composed of integer numbers of helium-4 nuclei. A rapid final explosive burning is caused by the sudden temperature spike owing to passage of the radially moving shock wave that was launched by the gravitational collapse of the core. W. D. Arnett and his Rice University colleagues demonstrated that the final shock burning would synthesize the non-alpha-nucleus isotopes more effectively than hydrostatic burning was able to do, suggesting that the expected shock-wave nucleosynthesis is an essential component of supernova nucleosynthesis. Together, shock-wave nucleosynthesis and hydrostatic-burning processes create most of the isotopes of the elements carbon (), oxygen (), and elements with (from neon to nickel). As a result of the ejection of the newly synthesized isotopes of the chemical elements by supernova explosions, their abundances steadily increased within interstellar gas. That increase became evident to astronomers from the initial abundances in newly born stars exceeding those in earlier-born stars.
https://en.wikipedia.org/wiki?curid=2443027
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The "George Washington" class were essentially "Skipjack" class submarines with a missile compartment, inserted between the ship's control/navigation areas and the nuclear reactor compartment. Contrary to some popular accounts, the "Skipjack"s were not literally "cut in half" to become ballistic missile submarines. The "Scorpion" had only been under construction for two months at Electric Boat in Groton, Connecticut before she was reordered as the "George Washington" (SSGN-598). Material and equipment ordered for the "Scamp" and "Sculpin" were used to build the "Patrick Henry" (SSGN-599) and "Theodore Roosevelt" (SSGN-600) at Electric Boat and Mare Island Naval Shipyard, respectively. Newport News Shipbuilding and Portsmouth Naval Shipyard built the "Robert E. Lee" (SSBN-601) and "Abraham Lincoln" (SSBN-602) without any components ordered for "Skipjack"-class submarines. The original hull classification of the first three units was SSGN(FBM) (Guided Missile Submarine, Fleet Ballistic Missile) which was changed to SSBN on 26 June 1958.
https://en.wikipedia.org/wiki?curid=231819
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On March 25, 1925, John Logie Baird demonstrated the transmission of moving pictures at the London department store Selfridges. Baird's device relied upon the Nipkow disk and thus became known as the mechanical television. It formed the basis of experimental broadcasts done by the British Broadcasting Corporation beginning on 30 September 1929. However, for most of the 20th century, televisions depended on the cathode ray tube invented by Karl Braun. The first version of such a television to show promise was produced by Philo Farnsworth and demonstrated to his family on 7 September 1927. After World War II, interrupted experiments resumed and television became an important home entertainment broadcast medium.
https://en.wikipedia.org/wiki?curid=33094374
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"Some of the professional and popular ambivalence toward ECT is related to the fact that we still do not know exactly how it works”. The lack of awareness on the effectiveness of ECT and the poor understanding of the exact functionality behind the treatment leads others to believe that ECT is unscientific. “The precise mechanism underlying the efficacy of ECT remains unclear, but one theory is that it promotes neuroplasticity by optimizing or “resetting” existing brain networks". ECT is thought to be morally wrong, just like other medical procedures that bring up controversy, such as abortion. However, “The best spokespeople for ECT are those patients and their family members who know from personal experience how debilitating depression can be and how effectively ECT can provide relief”.
https://en.wikipedia.org/wiki?curid=51477023
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Low angle trajectories normally used by guns, howitzers and rockets were more difficult. Purely ballistic low-angle trajectories are lopsided, being relatively parabolic for the start of the flight but becoming much more curved near the end. This is further modified by otherwise minor effects like wind, air pressure differences and aerodynamic effects, which have time to add up to a noticeable effect on long-range fire but can be ignored for short-range systems like mortars. These effects are minimized immediately after launch, but the low angle makes it difficult to see the rounds during this time, in contrast to a mortar which climbs above the horizon almost immediately. Adding to the problem is the fact that traditional artillery shells make for difficult radar targets.
https://en.wikipedia.org/wiki?curid=1543320
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Although the DC-3 had never been part of the original ILRV plans, Faget's name was so well respected that others at NASA MSC in Houston quickly rallied around him. Other NASA departments all selected their own favorite designs, including recoverable versions of Saturn boosters developed at the Marshall Space Flight Center in Huntsville, lifting-bodies based on the HL-10 that were favored by the Langley Research Center and Dryden Flight Research Center (Edwards), and even a single-stage-to-orbit Aerospaceplane were also proposed. From then on, the entire program was beset with in-fighting between the various teams. On 1 June 1969, a report was published that attacked the DC-3 design, followed by several others over the remainder of the year. In spite of this, North American quickly took up the DC-3 design, having learned over the years that the best way to win a NASA contract was to make whatever design Faget favored. They won contract NAS9-9205 to develop the DC-3 in December 1969.
https://en.wikipedia.org/wiki?curid=18952422
1,340,636
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The difference between languages does not consist only in differences in pronunciation, vocabulary or grammar, but also in different "cultures of speaking". Some cultures for example have elaborate systems of "social deixis", systems of signalling social distance through linguistic means. In English, social deixis is shown mostly though distinguishing between addressing some people by first name and others by surname, but also in titles such as "Mrs.", "boy", "Doctor" or "Your Honor", but in other languages such systems may be highly complex and codified in the entire grammar and vocabulary of the language. In several languages of east Asia, for example Thai, Burmese and Javanese, different words are used according to whether a speaker is addressing someone of higher or lower rank than oneself in a ranking system with animals and children ranking the lowest and gods and members of royalty as the highest. Other languages may use different forms of address when speaking to speakers of the opposite gender or in-law relatives and many languages have special ways of speaking to infants and children. Among other groups, the culture of speaking may entail "not speaking" to particular people, for example many indigenous cultures of Australia have a taboo against talking to one's in-law relatives, and in some cultures speech is not addressed directly to children. Some languages also require different ways of speaking for different social classes of speakers, and often such a system is based on gender differences, as in Japanese and Koasati.
https://en.wikipedia.org/wiki?curid=41831802
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In the 19th and early 20th century, American elm was a common street and park tree owing to its tolerance of urban conditions, rapid growth, and graceful form. This however led to extreme overplanting of the species, especially to form living archways over streets, which ultimately produced an unhealthy monoculture of elms that had no resistance to disease and pests. Elms do not naturally form pure stands and trees used in landscaping were grown from a handful of cultivars, causing extremely low genetic diversity. These trees' rapid growth and longevity, leading to great size within decades, made them popular before the advent of DED. Ohio botanist William B. Werthner, discussing the contrast between open-grown and forest-grown American elms, noted that:
https://en.wikipedia.org/wiki?curid=74223
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In NSW the first attempt to incorporate environmental assessment and protection into planning law began in 1974 with the appointment of a Planning and Environment Commission to overhaul the existing predominately urban land-use system. After various delays the Environmental Planning and Assessment Act 1979 (EP&A Act) came into force on 1 September 1980. The EP&A Act incorporated a three tired system of State, Regional and Local levels of significance, and required the relevant control authority to take into consideration the impacts to the environment (both natural and built) and the community of proposed development or land-use change. Within the EP&A Act most development requires a Statement of Environmental Effects (SEE) or Review of Environmental Effects (REF) detailing the impacts to both natural and human environments, which should be taken into consideration by the regulatory authority. Significant projects require a more thorough Environmental Impact Assessment with a corresponding greater public scrutiny.
https://en.wikipedia.org/wiki?curid=3909826
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